CN205268806U - Heart in situ perfusion system based on pressure signal gate - Google Patents
Heart in situ perfusion system based on pressure signal gate Download PDFInfo
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- CN205268806U CN205268806U CN201520449691.3U CN201520449691U CN205268806U CN 205268806 U CN205268806 U CN 205268806U CN 201520449691 U CN201520449691 U CN 201520449691U CN 205268806 U CN205268806 U CN 205268806U
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- hydraulic pump
- pressure
- heart
- pressure signal
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Abstract
The utility model discloses a heart in situ perfusion system based on pressure signal gate belongs to medical instrument technical field, and the system includes pouring guide pipe, pressure sensor, hydraulic pump and signal discriminator, hydraulic pump and pressure sensor are connected respectively through the infusion connecting pipe to the end of two inner tubes of pouring guide pipe straight section part, and pumping of endcapped and the side's of side open -ended inner tube and hydraulic pump mouthful communicates with each other, and terminal open -ended inner tube communicates with each other with pressure sensor, and pressure sensor can send the pressure signal that the during operation recorded to the signal discriminator, the signal discriminator to pressure signal handle the back to the hydraulic pump send start or stop signal with control infusion opportunity. The utility model discloses can realize the long -time infusion of cytokine stem cell, have security, easy operation concurrently, characteristics that target nature is high have improved the treatment that the ischemic heart declines.
Description
Technical field
This utility model relates to a kind of perfusion system realizing administration for ischemic heart desease, is specifically related to a kind of heart in-situ perfusion system, belongs to technical field of medical instruments.
Background technology
Ischemic heart desease is the common disease of serious threat human health. Current conventional therapy offer limited effectiveness, stem cell transplantation, cytokine infusion of therapeutic ischemic heart desease demonstrate huge potentiality, but need to play in position therapeutical effect, it is to avoid the picked-up of periphery non-target tissue utilizes.
Traditional heart delivery mode includes intracoronary injection, injection transplantation and being intravenously injected with in intramyocardial injection, Epicardium.
Injection transplantation in subendocardiac muscle: determine cardiac infarct sites, scope by endocardium Electrophysiological mapping, by injection catheter infarction tissue surrounding injection stem cell, there is the feature of accurate positioning, but operating process is complicated, consuming time, skills involved in the labour require height, and apparatus expensive, the application of restriction the method.
Injection transplantation in Epicardium: generally carry out while the open chest surgery such as bypass operation of coronary artery or prosthetic valve replacement, the method accurate positioning, it is simple to quantify and late detection, but due to needs open chest surgery, accommodator is less.
Through vein transplantation: be stem cell transplantation method the most simply and easily, but the transplanted cells factor needs through systemic circulation, and great majority are arrested in pulmonary and liver, and only a small amount of cell can arrive cardiac muscular tissue, so transplanting inefficiency; Cytokine is then degraded and is utilized by surrounding tissue picked-up, and target tissue effective dose is low, easily causes side effect.
Intracoronary injection is transplanted: for the most frequently used injection transplantation technology, the method adopting percutaneous coronary intervention (pci), guides through guiding catheter and coronary guide wire, microtubular or microsphere is encapsulated the coronary artery closing selection, utilize pressure by stem cell, cytokine infusion, reduce and overflow; For avoiding conduit or the long-time indwelling of sacculus to cause thrombosis in arteria coronaria, complete infusion with the fastest speed.
In four kinds of methods, intracoronary injection is the most common, next to that injection in Epicardium. Both approaches has a common feature, had both required once to complete in a short period of time to transplant, and had continued medication or the probability transplanted there's almost no. With under physiological condition, stem cell is by inflammatory mediator induction, chemotactic, the process progressively migrated to damaged myocardium along blood vessel is compared, and conventional implantation method has huge difference with physiological process at present, thus is probably stem-cell therapy effect and also reaches far away one of intended factor. Disposable infusion cytokine is because of the continuous erosion effect of blood flow, and after intracoronary injection, the interior concentration of cardiac muscle is relatively low, reduces the direct effect to heart, and a large amount of cytokines are absorbed by other non-target tissues with blood flow entrance body circulation simultaneously, it is understood that there may be potential hazard. In cardiac muscle, direct injection avoids the side effect such as first pass effect and the hypotension of intravascular injection, there is the advantages such as local drug concentration height, targeting be good, but intramyocardial injection is held time of short duration in local after needing opening operation breast, cytokine injections, and the shortcoming such as the formation of skewness, hemangioma and inflammatory reaction.
Utility model content
In view of this, this utility model provides a kind of heart in-situ perfusion system based on pressure signal gate, it is possible to realizes the long-time infusion of cytokine/stem cell, has safety concurrently, easily operates, the feature that targeting is high, improves the therapeutic effect of Ischemic heart failure.
A kind of heart in-situ perfusion system based on pressure signal gate, including perfusion conduit, hydraulic pump, infusion connecting tube, pressure transducer and signal screening device;
Wherein, described perfusion conduit includes managing in two within external coating and external coating, the outer surface of described two interior pipes is coated with completely by external coating, its monnolithic case is made up of straight part and hook portion, described hook portion is made up of segmental arc and straightway, and segmental arc connects with straight part; Two interior pipes one of described straightway corresponding position are endcapped and side opening, and another is distal opening, and its opening of interior pipe of side opening runs through external coating, and the end of two interior pipes that described straight part is corresponding is open architecture;
Described pressure transducer energy sensed pressure signal and by pressure signal transmission to signal screening device;
Described discriminator can judge diastole time-histories according to the pressure signal received, and hydraulic pump sends the control signal of on an off, controls the administration of hydraulic pump property performance period;
Its integrated connection relation is: the end of described perfusion two interior pipes of conduit straight part connects hydraulic pump and pressure transducer respectively by infusion connecting tube, the interior pipe of endcapped and side opening communicates with the pump discharge of hydraulic pump, open-ended interior pipe communicates with pressure transducer, described pressure transducer and the electrical connection of signal screening device, pressure transducer can send the pressure signal recorded when working to signal screening device; Described hydraulic pump and the electrical connection of signal screening device, send hydraulic pump after the pressure signal process to receiving of the signal screening device and start or stop command signal.
Further, when described signal screening device detects decent 1/3rd position, place of heavily rich ripple in a pressure wave unit, the relaxing period of this position correspondence heart, hydraulic pump is sent enabling signal; Wave trough position before the upstroke of next pressure wave unit, the systole of this position correspondence heart, hydraulic pump is sent termination signal.
Further, when described hydraulic pump receives termination signal, perform 10 milliseconds of pumpback actions.
Further, described external coating is formed by polythene material and steel wire sulfuration, polythene material determines the perfusion hardness of conduit, shape and the frictional force with tunica intima, and steel wire forms the skeleton of perfusion conduit, makes perfusion catheter lumen will not subside and have the anti-effect of fractureing.
Further, described perfusion conduit straight part is length 105-110cm, and the external diameter of conduit is 5F-7F.
Further, the arc radius of the segmental arc of described perfusion conduit hook portion is 3-5mm, and the length of straightway is 8-12mm.
Further, described pressure transducer, signal screening device and hydraulic pump are integrated and are constituted an assembly, it is simple to medical personnel are operated and safeguard.
Operation principle: during use, heart in-situ perfusion conduit of the present utility model is placed into through femoral artery the corresponding site of heart, opening correspondence arteria coronaria Dou Kou position, side on the straightway of hook portion, open-ended interior pipe senses the pressure of this position by connecting pressure transducer, and to signal screening device sending pressure signal; Pressure signal obtains diastole time-histories after signal screening device processes, and signal screening device controls hydraulic pump and presses the rule startup of diastole time-histories, carries liquid by the interior pipe of side opening to heart.
Beneficial effect:
1, this utility model utilizes the blood flow of arteria coronaria Dou Kou to flow mostly to physiological characteristics coronarius at diastole, indwelling near the arteria coronaria Dou Kou that delivery conduit is delivered to aortic root by peripheral arterial, conduit does not enter in coronary artery, at diastole by hydraulic pump through delivery conduit by stem cell, cytokine infusion, systole stops, and cell/liquid enters coronary artery with coronary blood flow.
2, hydraulic pump selectivity relaxing period of the present utility model starts function signal discriminator and controls, it is possible to control perfusion opportunity accurately. Heart in-situ perfusion approach avoids the potential risk (caused that acute coronary is narrow or inaccessible by conduit, steel wire, sacculus coup injury lumen of vessels, arteria coronaria perforation and cardiac tamponade, No-reflow phenoment etc. seriously jeopardize the coronary artery lesions complication of patient vitals) of open chest surgery and intracoronary catheter operation repeatedly, safety is higher, implement more easy, it is possible to realize long-time perfusion.
3, this utility model performs 10 milliseconds of pumpback actions when each transfusion stop, avoid in liquid-transport pipe-line liquid and the phenomenon that the cytokine/stem cell oozed out is sent out with artery blood flow whole body occurs due to pressure inertia, reduce the side effect of drugs on patients, can effectively save treatment cost simultaneously.
Accompanying drawing explanation
Fig. 1 is system theory of constitution schematic diagram of the present utility model.
Fig. 2 is the contour structures schematic diagram irrigating conduit in this utility model;
Fig. 3 is the structural representation of perfusion conduit straight part of the present utility model;
Fig. 4 is the straightway application principle figure at endocardial of perfusion conduit hook portion of the present utility model;
Fig. 5 is pressure signal gating principles figure of the present utility model.
Wherein, 1-external coating, pipe II, 6-straight part, 7-hook portion in pipe I, 4-side opening, 5-in 2-distal opening, 3-.
Detailed description of the invention
Develop simultaneously embodiment below in conjunction with accompanying drawing, this utility model is described in detail.
As shown in Figure 1, this utility model provides a kind of heart in-situ perfusion system based on pressure signal gate, including perfusion conduit, infusion connecting tube, pressure transducer, hydraulic pump and signal screening device;
Wherein, described perfusion conduit includes the interior pipe I 3 within external coating 1 and external coating and interior pipe II 5, the outer surface of said inner tube I 3 and interior pipe II 5 is coated with completely by external coating 1, as shown in Figure 2, its monnolithic case is made up of straight part 6 and hook portion 7, described hook portion 7 is made up of segmental arc and straightway, and segmental arc connects with straight part 6; As shown in Figure 3, the endcapped of the interior pipe I 3 of described straightway corresponding position and there is side opening 4, the distal opening of interior pipe II 5, the side opening of interior pipe I 3 runs through external coating 1, and interior pipe I 3 and the end of interior pipe II 5 that described straight part is corresponding are open architecture; The length of described perfusion conduit straight part is 110cm, and the external diameter of conduit is 6F, and the arc radius of the segmental arc of perfusion conduit hook portion is 4mm, and the length of straightway is 10mm; Described external coating 1 is formed by polythene material and steel wire sulfuration, and polythene material determines the perfusion hardness of conduit, shape and the frictional force with tunica intima, and steel wire forms the skeleton of perfusion conduit, makes perfusion catheter lumen will not subside and have and resists the effect of fractureing.
Described pressure transducer energy sensed pressure signal and by pressure signal transmission to signal screening device;
Described signal screening device can judge diastole time-histories according to the pressure signal received, and hydraulic pump is sent out and control signal, controls the administration of hydraulic pump property performance period;
Its integrated connection relation is: in described perfusion conduit straight part, the end of pipe I 3 and interior pipe II 5 connects hydraulic pump and pressure transducer respectively by infusion connecting tube, interior pipe I 3 communicates with the pump discharge of infusion pump, interior pipe II 5 communicates with pressure transducer, described pressure transducer and the electrical connection of signal screening device, pressure transducer can send the pressure signal recorded when working to signal screening device; Described hydraulic pump and the electrical connection of signal screening device, send hydraulic pump after the pressure signal process to receiving of the signal screening device and start or stop command signal.
Operation principle: during use, as shown in Figure 4, heart in-situ perfusion conduit of the present utility model is placed into through femoral artery the corresponding site of heart, opening correspondence arteria coronaria Dou Kou position, side on the straightway of hook portion, open-ended interior pipe senses the pressure of this position by the pressure transducer that opening connects in hydraulic pump, and to signal screening device sending pressure signal; As shown in Figure 5, when described signal screening device detects decent 1/3rd position, place of heavily rich ripple in a pressure wave unit, the relaxing period of this position correspondence heart, hydraulic pump is sent enabling signal; Wave trough position before the upstroke of next pressure wave unit, the systole of this position correspondence heart, hydraulic pump is sent termination signal; When each hydraulic pump receives termination signal, perform 10 milliseconds of pumpback actions.
Signal screening device controls hydraulic pump and presses the rule startup of diastole time-histories, carries liquid by the interior pipe of side opening to the Dou Kou of heart, it is ensured that medicinal liquid can enter endocardial completely.
In sum, these are only preferred embodiment of the present utility model, be not intended to limit protection domain of the present utility model. All within spirit of the present utility model and principle, any amendment of making, equivalent replacement, improvement etc., should be included within protection domain of the present utility model.
Claims (7)
1. the heart in-situ perfusion system based on pressure signal gate, it is characterised in that include perfusion conduit, hydraulic pump, infusion connecting tube, pressure transducer and signal screening device;
Wherein, described perfusion conduit includes managing in two within external coating and external coating, the outer surface of described two interior pipes is coated with completely by external coating, its monnolithic case is made up of straight part and hook portion, described hook portion is made up of segmental arc and straightway, and segmental arc connects with straight part; Two interior pipes one of described straightway corresponding position are endcapped and side opening, and another is distal opening, and its opening of interior pipe of side opening runs through external coating, and the end of two interior pipes that described straight part is corresponding is open architecture;
Described pressure transducer energy sensed pressure signal and by pressure signal transmission to signal screening device;
Described discriminator can judge diastole time-histories according to the pressure signal received, and hydraulic pump is sent out and control signal, controls the administration of hydraulic pump property performance period;
Its integrated connection relation is: the end of described perfusion two interior pipes of conduit straight part connects hydraulic pump and pressure transducer respectively by infusion connecting tube, the interior pipe of endcapped and side opening communicates with the pump discharge of hydraulic pump, open-ended interior pipe communicates with pressure transducer, described pressure transducer and the electrical connection of signal screening device, pressure transducer can send the pressure signal recorded when working to signal screening device; Described hydraulic pump and the electrical connection of signal screening device, send hydraulic pump after the pressure signal process to receiving of the signal screening device and start or stop command signal.
2. the heart in-situ perfusion system based on pressure signal gate as claimed in claim 1, it is characterized in that, when described signal screening device detects decent 1/3rd position, place of heavily rich ripple in a pressure wave unit, the relaxing period of this position correspondence heart, hydraulic pump is sent enabling signal; Wave trough position before the upstroke of next pressure wave unit, the systole of this position correspondence heart, hydraulic pump is sent termination signal.
3. the heart in-situ perfusion system based on pressure signal gate as claimed in claim 2, it is characterised in that when described hydraulic pump receives termination signal, perform 10 milliseconds of pumpback actions.
4. the heart in-situ perfusion system based on pressure signal gate as claimed in claim 3, it is characterised in that described external coating is formed by polythene material and steel wire sulfuration.
5. the heart in-situ perfusion system based on pressure signal gate as claimed in claim 3, it is characterised in that described perfusion conduit straight part is length 105-110cm, and the external diameter of conduit is 5F-7F.
6. the heart in-situ perfusion system based on pressure signal gate as claimed in claim 3, it is characterised in that the arc radius of the segmental arc of described perfusion conduit hook portion is 3-5mm, and the length of straightway is 8-12mm.
7. the heart in-situ perfusion system based on pressure signal gate as described in any one of claim 1-6, it is characterised in that described pressure transducer, signal screening device and hydraulic pump are integrated and constituted an assembly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520449691.3U CN205268806U (en) | 2015-06-26 | 2015-06-26 | Heart in situ perfusion system based on pressure signal gate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520449691.3U CN205268806U (en) | 2015-06-26 | 2015-06-26 | Heart in situ perfusion system based on pressure signal gate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN205268806U true CN205268806U (en) | 2016-06-01 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201520449691.3U Withdrawn - After Issue CN205268806U (en) | 2015-06-26 | 2015-06-26 | Heart in situ perfusion system based on pressure signal gate |
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| Country | Link |
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| CN (1) | CN205268806U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105126238A (en) * | 2015-06-26 | 2015-12-09 | 中国人民解放军总医院 | Heart in-situ perfusion system based on pressure signal gating |
-
2015
- 2015-06-26 CN CN201520449691.3U patent/CN205268806U/en not_active Withdrawn - After Issue
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105126238A (en) * | 2015-06-26 | 2015-12-09 | 中国人民解放军总医院 | Heart in-situ perfusion system based on pressure signal gating |
| CN105126238B (en) * | 2015-06-26 | 2018-11-27 | 中国人民解放军总医院 | A kind of heart situ perfusion system based on pressure signal gate |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| AV01 | Patent right actively abandoned |
Granted publication date: 20160601 Effective date of abandoning: 20181127 |
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| AV01 | Patent right actively abandoned |