CN105126238A - Heart in-situ perfusion system based on pressure signal gating - Google Patents
Heart in-situ perfusion system based on pressure signal gating Download PDFInfo
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- CN105126238A CN105126238A CN201510364718.3A CN201510364718A CN105126238A CN 105126238 A CN105126238 A CN 105126238A CN 201510364718 A CN201510364718 A CN 201510364718A CN 105126238 A CN105126238 A CN 105126238A
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Abstract
The invention discloses a heart in-situ perfusion system based on pressure signal gating and belongs to the technical field of medical instruments. The system comprises a perfusion guide pipe, a pressure sensor, a hydraulic pump and a signal discriminator. The tail ends of two inner pipes in a straight section portion of the perfusion guide pipe are connected with the hydraulic pump and the pressure sensor through the infusion connecting pipe respectively, the inner pipe with the tail end closed and the lateral side open is communicated with a pump outlet of the hydraulic pump, the inner pipe with the tail end open is communicated with the pressure sensor, the pressure sensor can transmit pressure signals measured during work to the signal discriminator, and the signal discriminator processes the pressure signals and then sends a starting or stopping signal to the hydraulic pump to control perfusion time. The heart in-situ perfusion system can realize long-time perfusion of cell factors or stem cells and has the advantages of safety, easiness in operation and high targeting ability, and treatment effect of ischemic heart failure is improved.
Description
Technical field
The present invention relates to a kind of filling system realizing administration for ischemic heart desease, be specifically related to a kind of heart in-situ perfusion system, belong to technical field of medical instruments.
Background technology
Ischemic heart desease is the common disease of serious threat human health.Current conventional therapy offer limited effectiveness, stem cell transplantation, cytokine infusion of therapeutic ischemic heart desease demonstrate huge potentiality, but need to play therapeutical effect in position, avoid periphery non-target tissue to absorb and utilize.
Traditional heart delivery mode comprises intracoronary injection, injection transplantation and through intravenous injection in intramyocardial injection, Epicardium.
Injection transplantation in subendocardiac muscle: by endocardium Electrophysiological mapping determination cardiac infarct sites, scope, by injection catheter infarction tissue surrounding injection stem cell, there is the feature of accurate positioning, but operating process is complicated, consuming time, skills involved in the labour require high, and apparatus expensive, the application of restriction the method.
Injection transplantation in Epicardium: usually carry out while the open chest surgery such as bypass operation of coronary artery or prosthetic valve replacement, the method accurate positioning, be convenient to quantize and late detection, but due to needs open chest surgery, accommodator is less.
Through vein transplantation: be stem cell transplantation method the most simply and easily, but the transplanted cells factor needs through systemic circulation, great majority are arrested in pulmonary and liver, only a small amount of cell can arrive cardiac muscular tissue, so transplant inefficiency; Cytokine is then degraded and is utilized by surrounding tissue picked-up, and target tissue effective dose is low, easily causes side effect.
Intracoronary injection is transplanted: be the most frequently used injection transplantation technology, adopt the method for percutaneous coronary intervention (pci), guide through guiding catheter and coronary guide wire, be encapsulated the coronary artery closing selection by microtubular or microsphere, utilize pressure by stem cell, cytokine infusion, reduce and overflow; For avoiding conduit or the long-time indwelling of sacculus to cause thrombosis in arteria coronaria, complete infusion with the fastest speed.
In four kinds of methods, intracoronary injection is the most common, is secondly injection in Epicardium.These two kinds of methods have a common feature, have both required once to complete transplanting in a short period of time, continue medication or the probability of transplanting exists hardly.With under physiological condition, stem cell is by inflammatory mediator induction, chemotactic, progressively compare to the process of damaged myocardium migration along blood vessel, at present conventional implantation method and physiological process have huge difference, thus may be stem-cell therapy effect also one of factors reaching expection far away.Disposable infusion cytokine is because of the continuous erosion effect of blood flow, and after intracoronary injection, in cardiac muscle, concentration is lower, reduces the direct effect to heart, and simultaneously a large amount of cytokine enters body circulation with blood flow and absorbed by other non-target tissues, may there is potential hazard.In cardiac muscle, direct injection avoids the side effect such as the first pass effect of intravascular injection and hypotension, there is the advantages such as local drug concentration is high, targeting is good, but hold time of short duration in local after intramyocardial injection needs opening operation breast, cytokine injections, and skewness, hemangioma are formed and the shortcoming such as inflammatory reaction.
Summary of the invention
In view of this, the invention provides a kind of heart in-situ perfusion system based on pressure signal gate, can realize the long-time infusion of cytokine/stem cell, have safety, easy to operate concurrently, the feature that targeting is high, improves the therapeutic effect of Ischemic heart failure.
Based on a heart in-situ perfusion system for pressure signal gate, comprise perfusion cannula, hydraulic pump, infusion connecting tube, pressure transducer and signal screening device;
Wherein, pipe in described perfusion cannula comprise external coating and external coating inside two, the outer surface of described two interior pipes is completely coated by external coating, its monnolithic case is made up of straight part and hook portion, described hook portion is made up of segmental arc and straightway, and segmental arc connects with straight part; Two interior pipes one of described straightway corresponding position are endcapped and side opening, and another is distal opening, and its opening of interior pipe of side opening runs through external coating, and the end of two interior pipes that described straight part is corresponding is open architecture;
Described pressure transducer energy sensed pressure signal by pressure signal transmission to signal screening device;
Described discriminator can judge diastole time-histories according to the pressure signal received, the control signal sending out hydraulic pump and close, the administration of hydraulic control pump property performance period;
Its integrated connection closes: the end of described perfusion cannula straight part two interior pipes is by infusion connecting tube connecting fluid press pump and pressure transducer respectively, endcapped and the interior pipe of side opening communicate with the pump discharge of hydraulic pump, open-ended interior pipe communicates with pressure transducer, described pressure transducer and signal screening device are electrically connected, and pressure transducer can send the pressure signal recorded during work to signal screening device; Described hydraulic pump and signal screening device are electrically connected, and signal screening device starts or stops command signal to sending hydraulic pump after the pressure signal process received.
Further, when described signal screening device detects decent 1/3rd position, place of heavily rich ripple in a pressure wave unit, the relaxing period of the corresponding heart in this position, sends enabling signal to hydraulic pump; Wave trough position before the upstroke of next pressure wave unit, the systole of the corresponding heart in this position, sends termination signal to hydraulic pump.
Further, when described hydraulic pump receives termination signal, perform 10 milliseconds of pumpback actions.
Further, described external coating is formed by polythene material and steel wire sulfuration, polythene material determines the hardness of perfusion cannula, shape and the frictional force with tunica intima, and steel wire forms the skeleton of perfusion cannula, makes that perfusion cannula chamber is unlikely to subside and have the anti-effect of fractureing.
Further, described perfusion cannula straight part be length 105-110cm, the external diameter of conduit is 5F-7F.
Further, the arc radius of the segmental arc of described perfusion cannula hook portion is 3-5mm, and the length of straightway is 8-12mm.
Further, formation assembly integrated by described pressure transducer, signal screening device and hydraulic pump, is convenient to medical personnel and carries out operation and maintenance.
Further, the material that described interior pipe adopts is polyethylene or polrvinyl chloride.
Operation principle: during use, heart in-situ perfusion conduit of the present invention is placed into the corresponding site of heart through femoral artery, the corresponding arteria coronaria Dou Kou position of side opening on the straightway of hook portion, the pressure of this position responded to by open-ended interior pipe by being communicated with pressure transducer, and to signal screening device sending pressure signal; Pressure signal obtains diastole time-histories after the process of signal screening device, and the rule that diastole time-histories pressed by signal screening device hydraulic control pump starts, by pipe in the opening of side to heart conveying liquid body.
Beneficial effect:
1, the present invention utilizes the blood flow of arteria coronaria Dou Kou to flow mostly to physiological characteristics coronarius at diastole, indwelling near the arteria coronaria Dou Kou through peripheral arterial delivery conduit being delivered to aortic root, conduit does not enter in coronary artery, at diastole by hydraulic pump through delivery conduit by stem cell, cytokine infusion, systole stops, and cell/liquid enters coronary artery with coronary blood flow.
2, hydraulic pump selectivity relaxing period start-up performance signal screening device of the present invention controls, and can control perfusion opportunity accurately.Heart in-situ perfusion approach avoids the potential risk (cause that acute coronary is narrow or inaccessible, arteria coronaria is bored a hole by conduit, steel wire, sacculus coup injury lumen of vessels and cardiac tamponade, No-reflow phenoment etc. seriously jeopardize the coronary artery lesions complication of patient vitals) of open chest surgery and intracoronary catheter operation repeatedly, safety is higher, implement more easy, long-time perfusion can be realized.
3, the present invention performs 10 milliseconds of pumpback actions when each transfusion stop, avoiding in liquid-transport pipe-line liquid due to pressure inertia there is the phenomenon that the cytokine/stem cell of oozing out is sent out with artery blood flow whole body, reduce the side effect of drugs on patients, effectively can save treatment cost simultaneously.
Accompanying drawing explanation
Fig. 1 is system theory of constitution schematic diagram of the present invention.
Fig. 2 is the contour structures schematic diagram of perfusion cannula in the present invention;
Fig. 3 is the structural representation of perfusion cannula straight part of the present invention;
Fig. 4 is the application principle figure of straightway at endocardial of perfusion cannula hook portion of the present invention;
Fig. 5 is pressure signal gating principles figure of the present invention.
Wherein, 1-external coating, pipe II, 6-straight part, 7-hook portion in pipe I, 4-side opening, 5-in 2-distal opening, 3-.
Detailed description of the invention
As shown in Figure 1, the invention provides a kind of heart in-situ perfusion system based on pressure signal gate, comprise perfusion cannula, infusion connecting tube, pressure transducer, hydraulic pump and signal screening device;
Wherein, described perfusion cannula comprises interior pipe I 3 and the interior pipe II 5 of external coating 1 and external coating inside, the outer surface of described interior pipe I 3 and interior pipe II 5 is completely coated by external coating 1, as shown in Figure 2, its monnolithic case is made up of straight part 6 and hook portion 7, described hook portion 7 is made up of segmental arc and straightway, and segmental arc connects with straight part 6; As shown in Figure 3, the endcapped of the interior pipe I 3 of described straightway corresponding position and there is side opening 4, the distal opening of interior pipe II 5, the side opening of interior pipe I 3 runs through external coating 1, and the end of the interior pipe I 3 that described straight part is corresponding and interior pipe II 5 is open architecture; The length of described perfusion cannula straight part is 110cm, and the external diameter of conduit is 6F, and the arc radius of the segmental arc of perfusion cannula hook portion is 4mm, and the length of straightway is 10mm; Described external coating 1 is formed by polythene material and steel wire sulfuration, polythene material determines the hardness of perfusion cannula, shape and the frictional force with tunica intima, steel wire forms the skeleton of perfusion cannula, make that perfusion cannula chamber is unlikely to subside and have the anti-effect of fractureing, the material of interior pipe I 3 and interior pipe II 5 is politef.
Described pressure transducer energy sensed pressure signal by pressure signal transmission to signal screening device;
Described signal screening device can judge diastole time-histories according to the pressure signal received, send out and control signal hydraulic pump, the administration of hydraulic control pump property performance period;
Its integrated connection closes: in described perfusion cannula straight part, the end of pipe I 3 and interior pipe II 5 is by infusion connecting tube connecting fluid press pump and pressure transducer respectively, interior pipe I 3 communicates with the pump discharge of infusion pump, interior pipe II 5 communicates with pressure transducer, described pressure transducer and signal screening device are electrically connected, and pressure transducer can send the pressure signal recorded during work to signal screening device; Described hydraulic pump and signal screening device are electrically connected, and signal screening device starts or stops command signal to sending hydraulic pump after the pressure signal process received.
Operation principle: during use, as shown in Figure 4, heart in-situ perfusion conduit of the present invention is placed into the corresponding site of heart through femoral artery, the corresponding arteria coronaria Dou Kou position of side opening on the straightway of hook portion, open-ended interior pipe responds to the pressure of this position by the opening pressure transducer be communicated with in hydraulic pump, and to signal screening device sending pressure signal; As shown in Figure 5, when described signal screening device detects decent 1/3rd position, place of heavily rich ripple in a pressure wave unit, the relaxing period of the corresponding heart in this position, sends enabling signal to hydraulic pump; Wave trough position before the upstroke of next pressure wave unit, the systole of the corresponding heart in this position, sends termination signal to hydraulic pump; When each hydraulic pump receives termination signal, perform 10 milliseconds of pumpback actions.
The rule that diastole time-histories pressed by signal screening device hydraulic control pump starts, and by the Dou Kou conveying liquid of pipe in the opening of side to heart, ensures that medicinal liquid can enter endocardial completely.
In sum, these are only preferred embodiment of the present invention, be not intended to limit protection scope of the present invention.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (7)
1. based on a heart in-situ perfusion system for pressure signal gate, it is characterized in that, comprise perfusion cannula, hydraulic pump, infusion connecting tube, pressure transducer and signal screening device;
Wherein, pipe in described perfusion cannula comprise external coating and external coating inside two, the outer surface of described two interior pipes is completely coated by external coating, its monnolithic case is made up of straight part and hook portion, described hook portion is made up of segmental arc and straightway, and segmental arc connects with straight part; Two interior pipes one of described straightway corresponding position are endcapped and side opening, and another is distal opening, and its opening of interior pipe of side opening runs through external coating, and the end of two interior pipes that described straight part is corresponding is open architecture;
Described pressure transducer energy sensed pressure signal by pressure signal transmission to signal screening device;
Described discriminator can judge diastole time-histories according to the pressure signal received, send out and control signal hydraulic pump, the administration of hydraulic control pump property performance period;
Its integrated connection closes: the end of described perfusion cannula straight part two interior pipes is by infusion connecting tube connecting fluid press pump and pressure transducer respectively, endcapped and the interior pipe of side opening communicate with the pump discharge of hydraulic pump, open-ended interior pipe communicates with pressure transducer, described pressure transducer and signal screening device are electrically connected, and pressure transducer can send the pressure signal recorded during work to signal screening device; Described hydraulic pump and signal screening device are electrically connected, and signal screening device starts or stops command signal to sending hydraulic pump after the pressure signal process received.
2. as claimed in claim 1 based on the heart in-situ perfusion system of pressure signal gate, it is characterized in that, when described signal screening device detects decent 1/3rd position, place of heavily rich ripple in a pressure wave unit, the relaxing period of the corresponding heart in this position, sends enabling signal to hydraulic pump; Wave trough position before the upstroke of next pressure wave unit, the systole of the corresponding heart in this position, sends termination signal to hydraulic pump.
3., as claimed in claim 2 based on the heart in-situ perfusion system of pressure signal gate, it is characterized in that, when described hydraulic pump receives termination signal, perform 10 milliseconds of pumpback actions.
4., as claimed in claim 3 based on the heart in-situ perfusion system of pressure signal gate, it is characterized in that, described external coating is formed by polythene material and steel wire sulfuration.
5., as claimed in claim 3 based on the heart in-situ perfusion system of pressure signal gate, it is characterized in that, described perfusion cannula straight part be length 105-110cm, the external diameter of conduit is 5F-7F.
6., as claimed in claim 3 based on the heart in-situ perfusion system of pressure signal gate, it is characterized in that, the arc radius of the segmental arc of described perfusion cannula hook portion is 3-5mm, and the length of straightway is 8-12mm.
7. the heart in-situ perfusion system based on pressure signal gate as described in any one of claim 1-7, is characterized in that, formation assembly integrated by described pressure transducer, signal screening device and hydraulic pump.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510364718.3A CN105126238B (en) | 2015-06-26 | 2015-06-26 | A kind of heart situ perfusion system based on pressure signal gate |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510364718.3A CN105126238B (en) | 2015-06-26 | 2015-06-26 | A kind of heart situ perfusion system based on pressure signal gate |
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| CN105126238A true CN105126238A (en) | 2015-12-09 |
| CN105126238B CN105126238B (en) | 2018-11-27 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108245227A (en) * | 2018-01-25 | 2018-07-06 | 西安交通大学医学院第附属医院 | Interventional treatment drug delivery device |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4459977A (en) * | 1981-03-27 | 1984-07-17 | Veronique Pizon | Coronary sinus retroperfusion apparatus for the treatment of myocardial ischemia |
| US4804358A (en) * | 1985-02-20 | 1989-02-14 | Medicorp Research Laboratories Corporation | Coronary perfusion pump |
| US20080262418A1 (en) * | 2007-04-05 | 2008-10-23 | Daniel Rogers Burnett | Automated Therapy System and Method |
| WO2015017714A2 (en) * | 2013-07-31 | 2015-02-05 | Cvdevices, Llc | Unitary body systems and devices and methods to use the same for retroperfusion |
| CN205268806U (en) * | 2015-06-26 | 2016-06-01 | 中国人民解放军总医院 | Heart in situ perfusion system based on pressure signal gate |
-
2015
- 2015-06-26 CN CN201510364718.3A patent/CN105126238B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4459977A (en) * | 1981-03-27 | 1984-07-17 | Veronique Pizon | Coronary sinus retroperfusion apparatus for the treatment of myocardial ischemia |
| US4804358A (en) * | 1985-02-20 | 1989-02-14 | Medicorp Research Laboratories Corporation | Coronary perfusion pump |
| US20080262418A1 (en) * | 2007-04-05 | 2008-10-23 | Daniel Rogers Burnett | Automated Therapy System and Method |
| WO2015017714A2 (en) * | 2013-07-31 | 2015-02-05 | Cvdevices, Llc | Unitary body systems and devices and methods to use the same for retroperfusion |
| CN205268806U (en) * | 2015-06-26 | 2016-06-01 | 中国人民解放军总医院 | Heart in situ perfusion system based on pressure signal gate |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108245227A (en) * | 2018-01-25 | 2018-07-06 | 西安交通大学医学院第附属医院 | Interventional treatment drug delivery device |
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| CN105126238B (en) | 2018-11-27 |
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