CN107343980A - A kind of more cavity foley's tubes - Google Patents
A kind of more cavity foley's tubes Download PDFInfo
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- CN107343980A CN107343980A CN201610250910.4A CN201610250910A CN107343980A CN 107343980 A CN107343980 A CN 107343980A CN 201610250910 A CN201610250910 A CN 201610250910A CN 107343980 A CN107343980 A CN 107343980A
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- cavity
- sacculus
- tube
- guiding tube
- distal end
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Classifications
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
- A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
- A61M25/0026—Multi-lumen catheters with stationary elements
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/1011—Multiple balloon catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
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- A—HUMAN NECESSITIES
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/1002—Balloon catheters characterised by balloon shape
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/1018—Balloon inflating or inflation-control devices
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M27/00—Drainage appliance for wounds or the like, i.e. wound drains, implanted drains
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- A61M29/00—Dilators with or without means for introducing media, e.g. remedies
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- A—HUMAN NECESSITIES
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- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/105—Balloon catheters with special features or adapted for special applications having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
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- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/1086—Balloon catheters with special features or adapted for special applications having a special balloon surface topography, e.g. pores, protuberances, spikes or grooves
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- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/1095—Balloon catheters with special features or adapted for special applications with perfusion means for enabling blood circulation while the balloon is in an inflated state or in a deflated state, e.g. permanent by-pass within catheter shaft
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- A61M2202/04—Liquids
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- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
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- Biomedical Technology (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Child & Adolescent Psychology (AREA)
- Otolaryngology (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
The invention discloses a kind of more cavity foley's tubes, including：Distal end is provided with the first body of the first sacculus, it is arranged in the first tubular body and distal end is provided with the second body of the second sacculus, it is arranged in the second tubular body and distally closes the guiding tube in hollow structure, and, the handle covering device connected with the first body, the second body and guiding tube；Wherein, multiple micropores are provided with first sacculus, handle covering device comprises at least first handle and second handle, one is formed between first body and the second body and is used for delivering therapeutic agents and the filling cavity being connected with first-hand handle chamber, one is formed between the second body and guiding tube and is used to convey balloon expandable liquid and the fluid-through chamber being connected with second-hand's handle chamber.More cavity foley's tubes of the present invention can be achieved quickly through complex lesions, the effect being accurately positioned not against guiding seal wire, and simple to operate, visual good, solve the problem that small distal blood vessels or branch's CTO lesions are carried out with effective perfusion therapy.
Description
Technical field
The present invention relates to medical instruments field, more particularly to a kind of more cavity foley's tubes.
Background technology
Conventional balloon conduit is a kind of under seal wire guiding, by percutaneous puncture or directly by cavity by sacculus
It is incorporated into patient vessel's system or other tube chambers such as oesophagus, tracheae, enteron aisle, bile duct or the urinary tract) enter
The medicine equipment of row dilatancy treatment.
It is more and more wider in the application of clinic as foley's tube interventional therapeutic technique is more and more ripe, it is multiple
Ratio more and more higher in miscellaneous lesions treatment.Foley's tube is applied to major diameter distal end lesion and bending branch disease
Become the important directions that treatment is developed recently.Distal end major diameter lesion and the lesion positioning of distal end bending branch
Relatively difficult, balloon expandable process is very easy to occur significantly to shift, at present solution clinically
It can be that operative doctor firmly holds the balloon catheter proximal end body of rod, reduce displacement amplitude or pumpback sacculus again as far as possible
Positioning and expansion.
Foley's tube is another important directions in the application of small cavity organization/tube chamber orientation treatment.Such as
Total coronary artery occlusion (Chronic Total Occlusions, CTO) lesion accounts for Coronary Artery Lesions
1/3, small distal blood vessels and far-end branch CTO lesions account for about the 20% of whole CTO lesions, but far
The patient that end thin vessels and far-end branch CTO lesions receive foley's tube PCI is really less than 8%, mainly
Reason is that foley's tube technically has difficult point.
The one of small distal blood vessels or branch's CTO lesions is characterized in that blood vessel diameter is small greatly, and is mostly that height is bent
Lesion, this require to do foley's tube size it is sufficiently small, and with it is soft can be with vascular bending
Premium properties, while can ensure that the thrust of balloon catheter proximal end can be effectively conducted to distal end again, ensure remote
End sacculus successfully passes through CTO lesions, and these technical characteristics bring great difficulty to conventional balloon microcatheter technology.
The single lumen balloon catheter of the prior art for being used to treat coronary chronic total occlusion, seal wire is irrigated
Chamber is designed as sharing cavity with balloon expandable filling cavity, so as to reduce the size of foley's tube.But so
Design it is still very limited to the effect of the size reduction of foley's tube, can not still arrive and ensure that foley's tube has
Effect reaches small distal blood vessels or branch's CTO lesions.Simultaneously because silk guide passage occupies the big portion of common-use tunnel
Divide space so that balloon expandable becomes very difficult with pumpback.Meanwhile conventional balloon conduit is through distally
Need to carry out repeatedly " take out, draw, be curved, turning " operation during small size lesion, the near-end body of rod is very easy to occur
Bending setting fractures.
In order to increase the clinical efficacy of conventional balloon conduit, given by carrying out targeting in balloon surface carrying medicine
The medicinal balloon catheter of medicine treatment is also rapidly developed in recent years.Medicinal balloon technology be by coating technology,
Medicine is attached to balloon surface, after sacculus is sent into diseased region, in the of short duration time of balloon expandable
Interior (0-2min) discharges medication coat to targeting pathological tissues or blood vessel, treats the disease such as narrow, inaccessible.
But medicinal balloon is disadvantageous in that, because medicinal balloon needs to carry out insoluble drug release in most time,
Therefore the adhesion of medication coat and balloon surface can not be too strong, which results in medicinal balloon course of conveying,
Substantial amounts of medication coat comes off, and the medication coat meeting normal tissue to come off produces harmful effect, or even production
Raw system toxicity.
In addition to common medicinal balloon, a kind of double-layered balloon catheter, internal layer sacculus in the prior art also be present
Play a part of expanding blood vessel, and outer layer sacculus is made up of the microporous barrier of uniqueness, will can be risen in process of expansion
Gene or medicine to therapeutic action penetrate into vascular wall, on target organ by outer layer sacculus, so as to ensure lesion
The drug dose that tissue or tube chamber need.The invention effectively overcomes loss of the medicine in course of conveying,
System toxicity is reduced, but because double-layered balloon design adds conduit body of rod size, can not be small to distal end
Blood vessel or branch's CTO lesions carry out effective perfusion therapy.In addition, the outer surface of outer layer sacculus is also settable
For micropore drug releasing membrane according, its both ends is connected with the straight active section of internal layer sacculus by viscose glue or laser welding
Connect, form medicine reservoir, liquid medicine or growth factor are stored in medicine reservoir.When capsula interna fills,
Under pressure, outer microtube bore expansion, medicine in medicine reservoir by the micropore quick release of expansion,
Targeting lesion is treated, so as to ensure the drug dose of pathological tissues or tube chamber needs.Although the invention
Medicine is stored in medicine reservoir, reduces the administration cavity in the foley's tube body of rod, is led so as to reduce
Pipe external diameter of rod body, but the body of rod size of reduction is still very limited, still can not be to small distal blood vessels or branch
CTO lesions are effectively treated.
The content of the invention
The invention provides a kind of more cavity foley's tubes, solving foley's tube in the prior art needs to coordinate
Guiding seal wire is guided and positioned, and the conduit body of rod size brought is larger, to small distal blood vessels or can not be divided
Branch CTO lesions carry out the problem of effective perfusion therapy.
According to one aspect of the present invention, there is provided a kind of more cavity foley's tubes, including：
First body, the distal end of the first body are provided with the first sacculus, multiple micropores are provided with the first sacculus；
The second body of the first tubular body is arranged in, one is formed between the first body and the second body for defeated
Send the filling cavity of therapeutic agent；Wherein, the distal end of the second body is provided with the second sacculus, and the second sacculus is arranged in
First balloon interior；
The guiding tube of the second tubular body is arranged in, one is formed between the second body and guiding tube and is used for conveyor ball
Capsule expands the fluid-through chamber of liquid；Wherein, the hollow structure that guiding tube is closed for distal end；And
The handle covering device connected with the first body, the second body and guiding tube, handle covering device at least wrap
Include：First-hand handle chamber and second-hand's handle chamber, wherein, filling cavity is connected with first-hand handle chamber, fluid-through chamber with
Second-hand's handle chamber is connected.
Alternatively, the distal end of guiding tube is linear pattern or screw type, and the distal end of guiding tube is circular arc Shape closed
Structure.
Alternatively, it is coated with metallic netted structural on the tube wall of guiding tube.
Alternatively, handle covering device also includes the 3rd handle cavity, and the distal end of guiding tube offers a conduction hole；
Wherein, more cavity foley's tubes also include：
The drainage tube being arranged in guiding tube, drainage tube extend along guiding tube, the distal end of drainage tube and conduction hole
Connection, the near-end of drainage tube connect with the 3rd handle cavity.
Alternatively, the distal end of guiding tube is additionally provided with multiple fill orifices.
Alternatively, the first sacculus includes：The first straight utricule, and first positioned at the first utricule both ends
Tapering, the first tapering are in horn-like, and multiple micropores are provided with the first utricule.
Alternatively, multiple tapered bulge-structures are provided with the first utricule.
Alternatively, the angle of the bearing of trend of the bearing of trend of tapered protrusion structure and the first utricule is 60 degree
To 120 degree.
Alternatively, the second sacculus includes：The second straight utricule, and second positioned at the second utricule both ends
Tapering, the second tapering is in horn-like.
Alternatively, the outer surface of the first body is provided with distance scale line.
Alternatively, more cavity foley's tubes also include：The mark locating ring being sheathed on outside the first body,
Mark locating ring is set close to the first sacculus.
Alternatively, the distal end of guiding tube is provided with a single saccule close to the region of the first sacculus or the second sacculus,
Single saccule includes：The 3rd straight utricule, and positioned at the 3rd tapering at the 3rd utricule both ends.
Alternatively, handle covering device also includes the 4th handle cavity, and more cavity foley's tubes also include：
The fluid-through tube being arranged in guiding tube, fluid-through tube extend along guiding tube, the distal end of fluid-through tube and single saccule
Connection, the near-end of fluid-through tube connect with the 4th handle cavity.
Alternatively, guiding tube is provided with corresponding to the region of the first sacculus, the second sacculus, and/or single saccule
Development point.
The beneficial effect of embodiments of the invention is：
The multi-cavity foley's tube with guiding seal wire without coordinating, you can realizes quickly through complex lesions, accurately
The effect of positioning, further, due to without coordinating with guiding seal wire, reducing size design limitation, energy
It is enough preferably to reach distal end small size lesion portion, solve and small distal blood vessels or branch's CTO lesions are entered
The problem of the effective perfusion therapy of row, can be simultaneously to near-end major diameter and distal end minor diameter or branch's pathological tissues
/ tube chamber carries out heavy dose of targeting perfusion therapy.
Brief description of the drawings
Fig. 1 represents the structural representation of more cavity foley's tubes of the embodiment of the present invention one；
Fig. 2 represents the structural representation one of the guiding tube distal end of the embodiment of the present invention one；
Fig. 3 represents the structural representation two of the guiding tube distal end of the embodiment of the present invention one；
Fig. 4 represents the structural representation of the first sacculus of the embodiment of the present invention one；
Fig. 5 represents the structural representation of the second sacculus of the embodiment of the present invention one；
Fig. 6 represents the structural representation of more cavity foley's tubes of the embodiment of the present invention two；
Fig. 7 represents the structural representation of more cavity foley's tubes of the embodiment of the present invention three；
Fig. 8 represents the structural representation of the first sacculus of the embodiment of the present invention three；
Fig. 9 represents the structural representation of more cavity foley's tubes of the embodiment of the present invention four；
Figure 10 represents the structural representation of more cavity foley's tubes of the embodiment of the present invention five；
Figure 11 represents the structural representation of more cavity foley's tubes of the embodiment of the present invention six；
Figure 12 represents the structural representation of the single saccule of the embodiment of the present invention six；
Figure 13 represents the structural representation one of more cavity foley's tubes of the embodiment of the present invention seven；
Figure 14 represents the structural representation two of more cavity foley's tubes of the embodiment of the present invention seven.
Wherein in figure：
1st, the first body, the 2, second body, 3, guiding tube, 4, handle covering device, 5, filling cavity, 6,
Fluid-through chamber, 7, drainage tube, 8, mark locating ring, 9, fluid-through tube；
11st, the first sacculus, 12, distance scale line；
21st, the second sacculus；
31st, conduction hole, 32, fill orifice, 33, single saccule, 34, development point；
41st, first-hand handle chamber, 42, second-hand's handle chamber, the 43, the 3rd handle cavity, the 44, the 4th handle cavity；
111st, the first utricule, the 112, first tapering, 113, bulge-structure, 114, micropore；
211st, the second utricule, the 212, second tapering；
331st, the 3rd utricule, the 332, the 3rd tapering.
Embodiment
The exemplary embodiment of the present invention is more fully described below with reference to accompanying drawings.Although shown in accompanying drawing
The exemplary embodiment of the present invention, it being understood, however, that may be realized in various forms the present invention without should be by
Embodiments set forth here is limited.Conversely, there is provided these embodiments are to be able to be best understood from this
Invention, and the scope of the present invention can be completely communicated to those skilled in the art.
Embodiment one
As shown in Figure 1 to Figure 3, the embodiment provides a kind of more cavity foley's tubes, including：
First body 1, the second body 2, guiding tube 3 and handle covering device 4.Below in conjunction with concrete application field
Explanation is explained in detail to above-mentioned all parts in scape and accompanying drawing.
First body 1 is the main body outer tube of more cavity foley's tubes, is provided with the distal end of the first body 1
First sacculus 11, the surface of first sacculus 11 are provided with multiple micropores for running through the cyst wall of the first sacculus 11
114, under a certain pressure, the liquid inside and outside the first sacculus 11 can be carried out by multiple micropores 114
Circulation.Wherein, the distal end of the first body 1 be more cavity foley's tubes targeted therapy end, the first body
1 near-end is connected with handle covering device 4.Preferably, the tube length of the first body 1 may be configured as
10-155cm, external diameter may be configured as 0.15-0.8cm.
Second body 2 is the main body inner tube of more cavity foley's tubes, and the second body 2 is arranged in the first body
In 1.That is, the first body 1 and the second body 2 are coaxial-type main body tubular construction, inner tube length and outer tube phase
Coordinate, length may be configured as 10-155cm, and the external diameter of main body outer tube may be configured as 0.15-0.8cm, in main body
The external diameter of pipe may be configured as 0.14-0.75cm.Wherein, one is formed between the second body 2 and the first body 1
For the filling cavity 5 of delivering therapeutic agents, wherein, the main function of the filling cavity 5 is for the first sacculus 11
Supply therapeutic agent.Further, the distal end of the second body 2 is provided with one second sacculus 21, second ball
Capsule 21 is arranged in inside the first sacculus 11, i.e. the first sacculus 11 is the outer layer ball of more cavity foley's tubes
Capsule, the second sacculus 21 are the internal layer sacculus of more cavity foley's tubes.Wherein, the distal end of the first sacculus 11
It is connected with face seal of the distal end of the second sacculus 21 with guiding tube 3.Preferably, second body 2
Tube length is engaged with the tube length of the first body 1, and external diameter may be configured as 0.14-0.75cm.First
The material of the body 2 of body 1 and second can use polyether block amide, nylon, polytetrafluoroethylene (PTFE), poly- ammonia
One kind or combinations thereof in ester, polyvinyl chloride, polypropylene, polymethacrylates.Further
The proximate material of two bodys 2 can use polyether block amide, nylon, polytetrafluoroethylene (PTFE), polyurethane, polychlorostyrene
One kind in ethene, polypropylene, polymethacrylates, stainless steel, Nitinol, titanium alloy or they
Combination.
Guiding tube 3 is arranged in the inside of the second body 2, and one is formed between the second body 2 and guiding tube 3 and is used
In the fluid-through chamber 6 of conveying balloon expandable liquid, fluid-through chamber 6 is used to convey expansion liquid to the second sacculus 21, makes
Second sacculus 21 is expanded, and so as to which the first sacculus 11 be expanded, makes the treatment inside the first sacculus 11
Agent is irrigated to diseased region by micropore 114.Wherein, when the first sacculus 11 or the second sacculus 21 fully expand
It is cylindric when opening.Further, the main function of the distal end of guiding tube 3 is guided by saccule, it is ensured that
Sacculus is set smoothly to reach lesion in the case where seal wire need not be guided.Further, guiding tube 3 is by near
End and distal end two parts composition, its length is 15-200cm, can be integral structure or
The split-type structural connected in a manner of glue or thermal weld, laser welding etc..
Wherein, guiding tube 3 is the hollow structure of distal end closing, adds guiding tube 3 in blood/body fluid
Buoyancy, allow guiding tube 3 with the quick motion in blood/body fluid flow direction distal end；Furthermore guiding tube 3
The mechanical strength and compliance of itself so that guiding tube 3 can answer lumen shape with rapid clockwise, pass through each
Class curved lumen.The near-end of guiding tube 3 provides excellent mechanotransduction performance simultaneously so that patient is easier
The position for the propulsion of adjustment guiding tube 3 distal end/withdraw and angle, improve guiding tube 3 and pass through complex lesions
Ability, so as to improve the ability that the first sacculus 11 and the second sacculus 21 pass through complex lesions.
Wherein, the near-end of guiding tube 3 can use the higher material of mechanotransduction ability, such as：Polytetrafluoroethylene (PTFE),
Polyether block amide, nylon, (high density) polyethylene, polyurethane, polyvinyl chloride, polypropylene, poly- first
One kind or combinations thereof in base acrylate, the distal end of guiding tube 3 can use the higher material of compliance,
Such as：Polytetrafluoroethylene (PTFE), polyether block amide, nylon, (high density) polyethylene, polyurethane, polychlorostyrene second
One kind or combinations thereof in alkene, polypropylene, polymethacrylates.The near-end of guiding tube 3 strengthens
The overall mechanical strength of foley's tube, can effectively prevent the excessive generation of stress during pushing/withdrawing
The problem of bending or fracture, reduce clinical operation risk；The near-end of guiding tube 3 can be by push power more simultaneously
The good sacculus and the distal end of guiding tube 3 that pass to distal end, so as to improve distal end successfully pass height bending,
The ability of Serious Stenosis lesion.The near-end of guiding tube 3 can play the enhancing of main body outer tube mechanics and power conduction increases
Use is pretended, bend resistance ability when by height curved lumen can be improved, while improves the power toward distal end
Conducting power is learned, makes the angles and positions of distal end handling stronger, bent so as to improve distal end by height,
The ability of stenotic lesion.
Further, the length of guiding tube 3 and the length of the first body 1 and the second body 2 are adapted, and are drawn
The inner chamber of conduit 3 is guidance cavity, and the guidance cavity is cavity structure, and is extended in handle covering device 4.
Handle covering device 4 is connected with the first body 1, the second body 2 and guiding tube 3, handle covering device
4 include multiple handle cavities, wherein, formed not between the first body 1, the second body 2 and guiding tube 3
The different handle cavity connections from handle covering device 4 respectively with cavity.Specifically, the handle covering device 4
Including：First-hand handle chamber 41 and second-hand's handle chamber 42.Wherein, between the first body 1 and the second body 2
The filling cavity 5 of formation connects with first-hand handle chamber 41, and what is formed between the second body 2 and guiding tube 3 is logical
Sap cavity 6 is connected with second-hand's handle chamber 42.
During practical application, after the first sacculus 11 and the second sacculus 21 arrival diseased region, pass through second-hand
The saline injection of handle chamber 42, the second sacculus 21 is fully expanded and be close to diseased region wall of the lumen, then lead to
Cross first-hand handle chamber 41 and inject therapeutic agent, therapeutic agent is delivered to the first sacculus 11 by filling cavity 5, then leads to
The micropore 114 for crossing the surface of the first sacculus 11 is expelled to pathological tissues/tube chamber, thus reach to pathological tissues/
Tube chamber carries out the purpose of high concentration targeting perfusion therapy.
In order to which fast positioning and targeting perfusion is better achieved, it is preferable that the distal end of above-mentioned guiding tube 3 can be set
Linear pattern or spiral shape are set to, quick in the case of completely without using guiding seal wire can reach lesion.
Distal end guiding tube is designed to linear pattern or screw type, when the distal end of guiding tube 3 is linear pattern, it is preferable to will
Straight length is arranged to 0.5-15.5cm, and external diameter is arranged to 0.1-1.5cm.When height is blocked, it is narrow small straight
, can be corresponding according to distal end or branch's pathological lumen diameter, selection when footpath distal end or linear pattern branch lesions treatment
The linear pattern distal end guiding tube foley's tube of model.When the distal end of guiding tube 3 is helical design, it is preferable to
It is 0.5-15mm by spiral external diameter, when to major diameter distal end or bending branch's lesions treatment, can uses
Screw type distal end guiding tube foley's tube, spiral-shaped structure can ensure distal end guiding tube in major diameter distal end disease
Become similar " spring effect " with fully adherent generations during bending branch lesions treatment, effectively prevent highly
Occur significantly to shift when proximal balloon is expanded in complete lesion.Preferably, the material of the distal end of guiding tube 3 can
Using the polytetrafluoroethylene (PTFE) with good mechanical strength and excellent compliance, polyether block amide, nylon, (height
Density) polyethylene, polyurethane, polyvinyl chloride, polypropylene, one kind in polymethacrylates or they
Combination；The proximal outer diameter of guiding tube 3 is consistent with distal outer diameter, and material can use polytetrafluoroethylene (PTFE), polyethers embedding
Section acid amides, nylon, (high density) polyethylene, polyurethane, polyvinyl chloride, polypropylene, polymethyl
One kind or combinations thereof in acid esters.Further, in order to prevent guiding tube 3 in course of conveying to people
Damage caused by body tissue or wall of the lumen, the distal end of preferably guiding tube 3 are arranged to circular arc enclosed construction.
In actual applications, when to height blocking, narrow small diameter distal or linear pattern branch lesions treatment,
It is linear more that according to distal end or branch's pathological lumen diameter, can select the distal end of guiding tube 3 of corresponding model
Cavity foley's tube, be advantageous to it and pass through the long and narrow tube chamber that height blocks.When to major diameter distal end or curved
During bent branch's lesions treatment, the distal end of guiding tube 3 that can use corresponding model is more cavity sacculus of screw type
Conduit, spiral-shaped structure can ensure guiding tube 3 in major diameter distal end lesion and bending branch lesions treatment mistake
It is fully adherent in journey, while spiral-shaped structure can allow the distal end of guiding tube 3 to occur similar " spring effect "
The first sacculus 11 and the second sacculus 21 are tangled, effectively prevents that sacculus exists in major diameter and height bending lesion
Process of expansion occurs significantly to shift, and improves the positioning precision of sacculus.
In order to further enhance the targeting of guiding tube 3, can be coated on the tube wall of guiding tube 3 metal net shaped
Structure, so as to further enhance power conducting effect and improve the mechanics enhancing effect of main body tube；It can especially increase
The mechanical strength of the strong distal end of guiding tube 3, the ability that linear pattern guiding tube passes through extreme stenotic lesion is improved, or
Improve " spring effect " of screw type distal end.Preferably, in order to ensure the tube wall surfaces externally and internally of guiding tube 3
Slickness and planarization, the metallic netted structural may be disposed between tube wall surfaces externally and internally, and not expose to interior
Any surface of outer surface.Wherein, the material of metallic netted structural can use the larger stainless steel of intensity,
Nitinol, titanium alloy material etc..In practical application, run into such as full Occlusion (CTO lesions) feelings
During condition, in order to strengthen the mechanical strength of the body 1 of guiding tube 3 and first and the second body 2, guiding tube 3
Netted stainless steel, Nitinol, wire made of titanium alloy material can also be coated in tube wall, so as to enter
One step improves overall bend resistance, fracture strength and power conducting effect；The mechanics that distal end can be strengthened simultaneously is strong
Degree, improve the ability that extreme stenotic lesion is passed through in distal end；In addition, the guiding tube 3 for having coated wire can be with
" spring effect " of screw type distal end is improved, prevents sacculus to be shifted in process of expansion.
Further, as shown in figure 4, the first sacculus 11 includes：The first straight utricule 111, and
Positioned at first tapering 112 at the both ends of the first utricule 111, the first tapering 112 is in horn-like, the first utricule 111
On be provided with multiple micropores 114.First utricule 111 of the first sacculus 11 is the straight effective of i.e. outer layer sacculus
Active section, the first tapering 112 of the first sacculus 11 are the loudspeaker on the straight effectively active section both sides of outer layer sacculus
Tapering, straight effectively active section and tapering can be a seamless integral structures or with glue
Or the Split type structure that thermal weld, the mode of laser welding connect.Wherein, the straight effective active section of outer layer sacculus
Wall is provided with micropore 114, and the aperture of micropore 114 is 5-100um, one-tenth porosity 3-50%, micropore 114 by
Chemical attack or laser engraving are made, and the aperture of micropore 114 and one-tenth porosity are by therapeutic agent viscosity and molecular weight
Depending on size, to reach the concentration for the treatment of agent required for pathological tissues/tube chamber treatment.
As shown in figure 5, the second sacculus 21 includes：The second straight utricule 211, and positioned at the second capsule
Second tapering 212 at the both ends of body 211, the second tapering 212 is in horn-like.Second capsule of the second sacculus 21
Body 211 is straight effective active section of i.e. internal layer sacculus, and the second tapering 212 of the second sacculus 21 is interior
The loudspeaker tapering on layer sacculus is straight effective active section both sides, straight effectively active section and tapering can be a nothing
The integral structure of seam or the Split type structure connected in a manner of glue or thermal weld, laser welding.
Preferably, effective length of work segment of internal layer sacculus may be configured as 1-25cm, and expanded outer diameter may be configured as
0.15-6.5cm；Effective length of work segment of outer layer sacculus than internal layer sacculus effective work segment length 1-5cm,
Outer layer balloon expandable external diameter is bigger 0.1-1cm than internal layer balloon expandable external diameter.The material of internal layer sacculus and outer layer sacculus
Expect for one kind in silica gel, latex, silicon rubber, polyurethane, nylon, polyether block amide or their group
Close.
To sum up, more cavity foley's tubes include inside and outside two layers of main body tube and one layer of guiding tube, wherein, in master
The distal end of body pipe is provided with the perfusion therapy that inside and outside two layers of sacculus is used for near-end major diameter pathological tissues/tube chamber,
That is internal layer sacculus and outer layer sacculus, wherein, internal layer sacculus be arranged at inner tube distal end, the distal end of internal layer sacculus with
Guiding tube is tightly connected, and internal layer sacculus is mainly used in expanding near-end major diameter pathological tissues/tube chamber.Outer layer ball
Capsule is covered in internal layer balloon surface, and surface is installed with nanometer or micron order micropore, it is preferable that aperture 5-100um,
One-tenth porosity 3-50%, micropore are made up of chemical attack or laser engraving, and it is remote that outer layer sacculus is arranged at main body outer tube
End, balloon expandable external diameter is bigger 0.1-1cm than internal layer sacculus, outer layer balloon distal and distal end guiding tube and capsula interna
Distal seal connects, and outer layer sacculus is mainly used in irrigating therapeutic agent to pathological tissues/tube chamber.More cavities
Foley's tube without with guiding seal wire coordinate, you can realize targeting and positioning, can quickly through complex lesions,
The effect being accurately positioned is realized, and it is simple to operate, visual good, solve to small distal blood vessels or branch
CTO lesions carry out the problem of effective perfusion therapy.
Embodiment two
Based on above-described embodiment one, below the present embodiment more cavity foley's tubes will be done further with reference to accompanying drawing
Ground introduction explanation.
As shown in fig. 6, more cavity foley's tubes except including above-mentioned first body 1, the second body 2,
Outside guiding tube 3 and handle covering device 4, in addition to one is arranged in drainage tube 7 in guiding tube 3.Wherein,
The distal end of guiding tube 3 offers a conduction hole 31, and the distal end of drainage tube 7 connects with conduction hole 31, and edge
Guiding tube 3 extends to handle covering device 4, and further, handle covering device 4 also includes the 3rd handle cavity 43,
The near-end of drainage tube 7 connects with the 3rd handle cavity 43.Wherein, the inner chamber of drainage tube 7 is drainage lumens,
Main function is suction/drainage tube chamber use for distal end pathological tissues/tube chamber infectivity hydrops, body fluid etc.,
Increase the perfusion clinical efficacy of successive treatment agent.Wherein, the length of drainage tube 7 is engaged with guiding tube 3,
Drainage tube 7 extends to the distal end of guiding tube 3 through the second sacculus 21, and is stretched out from tube wall, drainage
Pipe 7 is tightly connected with the tube wall intersection of guiding tube 3；The inner chamber of drainage tube 7 is drainage lumens, and drainage lumens are draining
Pipe intersects with the tube wall of guiding tube 3 is provided with a conduction hole 31 at sealed connection, aperture 0.15-2.5mm,
Drainage lumens near-end is connected with the 3rd handle cavity 43 of handle covering device 4.
Further, the distal end of guiding tube 3 is additionally provided with multiple fill orifices 32, i.e. linear pattern or screw type
Guiding tube distal end on be provided with multiple fill orifices 32, at this moment the inner chamber of guiding tube 3 is as perfusion liquid cavity
Use.Preferably, it is 0.2-6mm that 1-5 aperture can be set in the guiding tube of linear pattern or screw type distal end
Fill orifice 32, the inner chamber of guiding tube 3 use as therapeutic agent filling cavity, can be to distal end pathological tissues/tube chamber
It is irrigated treatment.
In practical application, infectious hydrops, blood etc. can cause perfusion therapy agent existing for the lesion region of distal end
Concentration weakens, while the flowing of infectious hydrops can increase irrigating region subinfection, the risk of lesion again.
Therefore, machinery or hand-held suction pump can be used to connect the 3rd handle cavity 43, by conduction hole 31 to distal end disease
Become regional infection hydrops, blood etc. to be aspirated or drained, create the distal environment of a relatively dry,
Then treatment is irrigated to near-end lesion region or distal end lesion region by first-hand handle chamber 41 again, from
And avoid due to the problem of perfusion therapy caused by distal end lesion region infectivity hydrops, blood etc. fails.
Embodiment three
As shown in Figure 7 and Figure 8, more cavity foley's tubes including above-mentioned first body 1, second except managing
Body 2, guiding tube 3 and handle covering device 4, the first sacculus 11 include：The first straight utricule 111, with
And positioned at first tapering 112 at the both ends of the first utricule 111, first tapering 112 is in horn-like, the first capsule
Multiple micropores 114 are provided with body 111.Specifically, it is provided with the first utricule 111 multiple tapered
Tapered protrusion structure 113.Tapered protrusion effectively is provided with active section in the straight of outer layer sacculus,
The top of tapered protrusion structure 113 is provided with multiple micropores 114, and the aperture of micropore 114 may be configured as
0.1-2.5mm, the top of tapered protrusion structure 113 to the vertical range of outer layer sacculus flat surface is 0.03-2
Cm, tapered protrusion structure 113 can prolong its straight effectively active section vertical protrusion row with outer layer balloon expandable
Arrange and insert at pathological tissues superficial, to realize that targeted therapy and depth are treated.Wherein, tapered protrusion structure
113 quantity can select according to diseased region and the order of severity, preferably may be configured as 2-30.Wherein,
Tapered protrusion structure 113 can be connected by way of bonding or welding with the first utricule 111.
In addition, the folder of the bearing of trend of the bearing of trend of above-mentioned tapered protrusion structure 113 and the first utricule 111
Angle is 60 degree to 120 degree, i.e., protrusion direction and the first utricule 111 of above-mentioned tapered protrusion structure 113
The angle in flat surface direction is 60 degree to 120 degree, preferably may be configured as 60 degree, 90 degree or 120
Degree.
In order to increase the clinical efficacy of near-end major diameter pathological tissues/tube chamber superficial layer, the embodiment of the present invention is also
The tapered protrusion structure 113 of larger aperture is further provided with the first utricule 111 of the first sacculus 11.
The sophisticated aperture of the tapered protrusion structure 113 is 0.1-2.5mm, vertical range of the top to straight active section
For 0.03-2cm, with the expansion of sacculus, tapered protrusion structure 113 prolongs the straight active section bump array of sacculus,
And insert and heavy dose of targeting perfusion therapy is carried out at tissue superficial, improve clinical efficacy.
In actual applications, tapered protrusion structure 113 prolongs the first sacculus with the expansion of the second sacculus 21
11 parallel vertical of the first utricule 111 arranges and inserts pathological tissues/official jargon superficial layer, and therapeutic agent passes through
Proficiency handle chamber 41 is injected and is delivered to micropore 114, then by tapered protrusion structure 114 inject pathological tissues/
The shallow surface region of tube chamber, so as to improve the clinical cure rate of tube chamber deep layer site morbidity.
Example IV
As shown in figure 9, more cavity foley's tubes except including above-mentioned first body 1, the second body 2,
Guiding tube 3 and handle covering device 4, it is additionally provided with the outer surface of the first body 1 and is pushed for accurately controlling
The distance scale line 12 of distance.Wherein, the air line distance of the distance scale line 12 is 1-10cm.In reality
In, patient can be according to the phase of distance scale line 12 and other auxiliary implements such as guiding catheter, hysteroscope
To change in location, the displacement of distal end of the present invention is controlled, improves positioning precision.
Embodiment five
As shown in Figure 10, more cavity foley's tubes except including above-mentioned first body 1, the second body 2,
Outside guiding tube 3 and handle covering device 4, more cavity foley's tubes also include being sheathed on outside the first body 1
Mark locating ring 8, the mark locating ring 8 sets close to the first sacculus 11.The mark locating ring 8 is
Circular raised or discount vibram outlet shape is raised, the near-end afterbody 0.2-5cm of 8 the first sacculus of distance of mark locating ring 11,
The thickness for marking locating ring 8 is 0.05-5cm, length 0.1-5cm.Wherein, to superficial cavity lesion
When being treated, the mark locating ring 8 can assist patient to judge that sacculus can touch tissue, intraluminal position
Put, i.e., the position judgment sacculus position that patient can be by touch mark locating ring 8 in superficial cavity,
To reduce patient's operation because being positioned such that the frequency with X ray or high frequency ultrasound, reduce the injury to human body.
Embodiment six
As shown in FIG. 11 and 12, more cavity foley's tubes including above-mentioned first body 1, second except managing
Body 2, guiding tube 3 and handle covering device 4, in the treatment applied to multiple-limb lesion, draw to improve
The positioning energy ability of the distal end of conduit 3, the distal end of guiding tube 3 is close to the first sacculus 11 or the second sacculus 21
Region is provided with a single saccule 33, and single saccule 33 specifically includes：The 3rd straight utricule 331, Yi Jiwei
In the 3rd tapering 332 at the both ends of the 3rd utricule 331.The single saccule 33 be hydraulic pressure expand single saccule, the 3rd
The tapering 332 of utricule 331 and the 3rd can be a seamless integral structure or with glue or hot weld
Connect, the Split type structure that the mode of laser welding connects.The sacculus 11 of single saccule 33 and first and the second sacculus
21 parallel arrangeds, the length of the 3rd utricule 331 is 1-10cm, external diameter 0.2-6cm.Single saccule 33
Proximally and distally it is connected with the face seal of guiding tube 3.
During treatment applied to multiple-limb lesion, in order to improve the stationkeeping ability of guiding tube 3, of the invention is more
Cavity foley's tube further can also set a hydraulic pressure to expand single saccule 33, Ke Yiyou in guiding tube 3
Effect reduces the incidence that " false chamber " is slipped into the distal end of guiding tube 3 during multiple-limb lesions treatment, and raising is faced
Bed therapeutic efficiency.
Further, handle covering device 4 also includes the 4th handle cavity 44, and more cavity foley's tubes also include：
The fluid-through tube 9 being arranged in guiding tube 3, fluid-through tube 9 extend along guiding tube 3, the distal end of fluid-through tube 9 with
Single saccule 33 connects, and the near-end of fluid-through tube 9 connects with the 4th handle cavity 44.I.e. fluid-through tube 9 is included in and drawn
Single saccule 33 is extended in conduit 3, and corresponds to the tube wall of the opening position of single saccule 33 from guiding tube 3
Stretch out, fluid-through tube 9 is tightly connected with the tube wall intersection of guiding tube 3；The inner chamber of fluid-through tube 9 as fluid-through chamber,
Fluid-through chamber is provided with a pore openings intersecting with the tube wall of guiding tube 3 at sealed connection, aperture is
0.15-2.5mm, fluid-through chamber near-end connect with the 4th handle cavity 44 of handle covering device 4.In guiding tube 3
A fluid-through tube 9 is provided with, fluid-through tube 9 extends to distal end and in the 3rd utricule 331 of single saccule 33
On offer the fill orifice of 1-2 balloon expandable liquid, perfusion liquid conveying when being expanded for single saccule 33.
Double-layered balloon is close to trunk tube chamber distal portion when expanding, and being close to branch's lesion during individual layer balloon expandable opens
At mouthful, it can effectively prevent distal end guiding tube from slipping into non-target lesion far-end branch under such as the washing away of blood.
When actual therapeutic highly bends branch's lesion, double-layered balloon is first pushed to the end of main branch cavity
Position, it is appropriate to expand the second sacculus 21, main body body is adjusted, by the distal end of guiding tube 3 and single saccule 33
Push at height bending branch cavity, it is appropriate to expand single saccule 33, and the second sacculus 21 is depressurized, enter one
The distal end of guiding tube 3 is pushed to branch's cavity distal end lesion region by step, adjusts the first body 1, it is ensured that guiding
The distal end of pipe 3 is fully adherent in distal end lesion cavity surface, fully expands single saccule 33 and completes guiding tube 3
Fixed, then the sacculus inside and outside abundant expansion, completes last perfusion therapy.
Embodiment seven
As shown in Figs. 13 and 14, more cavity foley's tubes including above-mentioned first body 1, second except managing
Body 2, guiding tube 3 and handle covering device 4.In order to increase visuality of the foley's tube under X ray, draw
The region that conduit 3 corresponds to the first sacculus 11, the second sacculus 21, and/or single saccule 33 is provided with development
Point 34.Wherein, effective active section part of each sacculus can add 1-2 corresponding to the surface of guiding tube 3
Individual development point 34；The distal portions of guiding tube 3 can add 2-10 development point 34, the number of development point 34
Amount and the quantity of fill orifice are in 2:1 coordinates, and development point 34 is arranged on the left and right sides of each fill orifice.
When clinic needs to carry out radiotherapy to near-end pathological tissues/tube chamber, the present invention can pass through past ball
The mode that capsule fills addition radioactive substance in liquid carries out targeting radiotherapy, radioactive substance to pathological tissues
Such as, I-131, phosphorus -32 etc..
To sum up, simple to operate, the visual good, accurate positioning of more cavity foley's tubes, not against drawing
Can be quickly through complex lesions in the case of seal wire；And guiding tube 3 is set by using the distal end of screw type
Meter, effectively prevent from that significantly sliding transfer occurs when proximal balloon from expanding；In addition, more cavity foley's tubes
Also there is preferable bend resistance/fracture property and mechanotransduction performance, preferably distal end is handling, can be simultaneously
Heavy dose of targeting perfusion therapy is carried out to near-end major diameter and distal end minor diameter or branch's pathological tissues/tube chamber,
And targeting perfusion therapy can be carried out to tissue/tube chamber deep layer lesion region.
It is worthy of note that above-mentioned pathological tissues and tube chamber comprise at least：Cavity organization/tube chamber include blood vessel,
Enteron aisle, tracheae, oesophagus, the urinary tract, bile duct, common hepatic duct, ureter, vagina, nasolacrimal duct, fallopian tubal etc..
Above-described is the preferred embodiment of the present invention, it should be pointed out that for the ordinary people of the art
For member, some improvements and modifications can also be made under the premise of principle of the present invention is not departed from, these
Improvements and modifications are also within the scope of the present invention.
Claims (14)
- A kind of 1. more cavity foley's tubes, it is characterised in that including：First body (1), the distal end of first body (1) are provided with the first sacculus (11), and described Multiple micropores (114) are provided with one sacculus (11)；It is arranged in internal the second body (2) of first body (1), first body (1) and institute State and a filling cavity (5) for being used for delivering therapeutic agents is formed between the second body (2)；Wherein, described second The distal end of body (2) is provided with the second sacculus (21), and second sacculus (21) is arranged in described first Sacculus (11) is internal；Be arranged in the internal guiding tube (3) of second body (2), second body (2) with it is described A fluid-through chamber (6) for being used to convey balloon expandable liquid is formed between guiding tube (3)；Wherein, the guiding Manage the hollow structure of (3) for distal end closing；AndThe hand connected with first body (1), second body (2) and the guiding tube (3) Sleeve device (4), the handle covering device (4) comprise at least：First-hand handle chamber (41) and second-hand Handle chamber (42), wherein, the filling cavity (5) is connected with the first-hand handle chamber (41), described logical Sap cavity (6) is connected with second-hand's handle chamber (42).
- 2. more cavity foley's tubes according to claim 1, it is characterised in that the guiding tube (3) Distal end be linear pattern or screw type, and the distal end of the guiding tube (3) is circular arc enclosed construction.
- 3. more cavity foley's tubes according to claim 1, it is characterised in that the guiding tube (3) Tube wall on be coated with metallic netted structural.
- 4. more cavity foley's tubes according to claim 1, it is characterised in that the handle suit Putting (4) also includes the 3rd handle cavity (43), and the distal end of the guiding tube (3) offers a conduction hole (31)；Wherein, more cavity foley's tubes also include：The drainage tube (7) being arranged in the guiding tube (3), the drainage tube (7) is along the guiding tube (3) extend, the distal end of the drainage tube (7) connects with the conduction hole (31), the drainage tube (7) Near-end connected with the 3rd handle cavity (43).
- 5. more cavity foley's tubes according to claim 4, it is characterised in that the guiding tube (3) Distal end be additionally provided with multiple fill orifices (32).
- 6. more cavity foley's tubes according to claim 1, it is characterised in that first sacculus (11) include：Straight the first utricule (111), and positioned at the first utricule (111) both ends First tapering (112), first tapering (112) are in horn-like, are set on first utricule (111) It is equipped with multiple micropores (114).
- 7. more cavity foley's tubes according to claim 6, it is characterised in that first utricule (111) multiple tapered bulge-structures (113) are provided with, the micropore (114) is arranged at described The top of bulge-structure (113).
- 8. more cavity foley's tubes according to claim 7, it is characterised in that the bulge-structure (113) angle of bearing of trend and the bearing of trend of first utricule (111) is 60 degree to 120 Degree.
- 9. more cavity foley's tubes according to claim 1, it is characterised in that second sacculus (21) include：Straight the second utricule (211), and positioned at the second utricule (211) both ends Second tapering (212), second tapering (212) is in horn-like.
- 10. more cavity foley's tubes according to claim 1, it is characterised in that first body (1) outer surface is provided with distance scale line (12).
- 11. more cavity foley's tubes according to claim 1, it is characterised in that also include：It is arranged In the outside mark locating ring (8) of first body (1), the mark locating ring (8) is close to described First sacculus (11) is set.
- 12. more cavity foley's tubes according to claim 1, it is characterised in that the guiding tube (3) Distal end the region of first sacculus (11) or the second sacculus (21) is provided with a single saccule (33), The single saccule (33) includes：The 3rd straight utricule (331), and positioned at the 3rd utricule (331) 3rd tapering (332) at both ends.
- 13. more cavity foley's tubes according to claim 12, it is characterised in that the taper knob Device (4) also includes the 4th handle cavity (44), and more cavity foley's tubes also include：The fluid-through tube (9) being arranged in the guiding tube (3), the fluid-through tube (9) is along the guiding tube (3) extend, the distal end of the fluid-through tube (9) connects with the single saccule (33), the fluid-through tube (9) Near-end connected with the 4th handle cavity (44).
- 14. more cavity foley's tubes according to claim 13, it is characterised in that the guiding tube (3) first sacculus (11), second sacculus (21), and/or the single saccule (33) are corresponded to Region be provided with development point (34).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610250910.4A CN107343980A (en) | 2016-04-21 | 2016-04-21 | A kind of more cavity foley's tubes |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610250910.4A CN107343980A (en) | 2016-04-21 | 2016-04-21 | A kind of more cavity foley's tubes |
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| Publication Number | Publication Date |
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| CN107343980A true CN107343980A (en) | 2017-11-14 |
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| CN201610250910.4A Pending CN107343980A (en) | 2016-04-21 | 2016-04-21 | A kind of more cavity foley's tubes |
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| CN111700659A (en) * | 2020-05-06 | 2020-09-25 | 中国人民解放军陆军军医大学第一附属医院 | Intracavitary blood vessel flow guiding device |
| CN111921024A (en) * | 2020-08-17 | 2020-11-13 | 西安交通大学医学院第一附属医院 | Abdominal cavity flushing drainage device |
| CN112057133A (en) * | 2020-09-15 | 2020-12-11 | 玮铭医疗器械(上海)有限公司 | Multifunctional treatment catheter |
| CN113244503A (en) * | 2020-09-03 | 2021-08-13 | 青岛博泰医疗器械有限责任公司 | Drug balloon catheter system |
| WO2021122803A3 (en) * | 2019-12-17 | 2021-08-19 | Cirlo Gmbh | Tubular shaped elongated catheter device for interacting with components of bodily fluids |
| CN114514046A (en) * | 2019-07-31 | 2022-05-17 | 奥卢森特生物医学公司 | Device and method for repairing tissue |
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