CN208770061U - A kind of aortic incompetence animal model making device - Google Patents
A kind of aortic incompetence animal model making device Download PDFInfo
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- CN208770061U CN208770061U CN201820123424.0U CN201820123424U CN208770061U CN 208770061 U CN208770061 U CN 208770061U CN 201820123424 U CN201820123424 U CN 201820123424U CN 208770061 U CN208770061 U CN 208770061U
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- aortic
- needle
- animal model
- incompetence
- making device
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Abstract
The utility model discloses a kind of aortic incompetence animal model making devices, belong to animal disease model technical field.Aortic incompetence animal model making device includes: puncture needle, needle catheter, left chamber tube, aortic catheters and monitoring device.Puncture needle runs through needle catheter, needle catheter, left chamber tube and aortic catheters interconnect, and monitoring device is connect with left chamber tube and aortic catheters respectively and monitoring device can convert waveform image and numerical value for the pressure signal in left chamber tube and aortic catheters.The aortic incompetence animal model making device integrated operation of the utility model is simple, quick, operation difficulty is low, technical difficulty is small and small to the wound of animal model, the survival rate of animal model is improved, the large size or meiofauna model of different degrees of aortic incompetence can be additionally made by this device.
Description
Technical field
The utility model relates to animal disease model technical fields, and in particular to a kind of aortic incompetence animal mould
Type producing device.
Background technique
Aortic incompetence is also known as aortic regurgitation, is a kind of heart disease that clinic is common.Aorta petal position
Between left ventricle and aorta, Normal aorta valve is trilobed structure, and ventricular systole aorta petal is opened, and left ventricle is by blood
Liquid injects aorta, and ventricular diastole aortic valve closing prevents aorta blood from returning to left ventricle.When aorta petal structure is sent out
Changing or other reasons may result in aortic incompetence, and left ventricular diastolic blood is from aortic regurgitation to a left side
Ventricle.Aortic incompetence patients with mild may be asymptomatic；Middle severe patient is likely to occur left ventricular end diastolic presssure and increases, is left
The room effectively often amount of fighting decline, pulmonary edema, congestive heart failure, cardiogenic shock are even dead；Severe patient is possible therefore sudden
Extremely, threat to life.Therefore, occurring principle and treatment of the stable animal model for research aortic incompetence are established
Method is all of great significance.
Aortic incompetence animal model is mainly built by destroying, changing aortic valve or annulus structure at present
It is vertical, to influence the closure of left ventricular diastolic aorta petal.Wherein most by surgery or intervention surgical disruption aortic valve
Easily realize, using such method cause aortic incompetence approach it is main there are three: surgical operation, X-ray guidance intervention
It is intervened with ultrasonic guidance.Surgical operation needs out chest to establish extracorporal circulatory system to destroy aorta petal under direct-view, and technical requirements are high, behaviour
Work is complicated, wound is big, animal easy infection, and mortality of animals is high.X-ray guidance intervention needs to monitor in digital subtraction angiography machine
Aortic valve is destroyed by special nipper down, technical difficulty is big, at high cost, and modelling personnel and animal are both needed to connect
It is radiated by X-ray.Ultrasonic guidance intervention need echocardiogram guiding in real time, to ultrasonic cardiography diagram technology and instrument and equipment have compared with
High request.
Utility model content
The purpose of this utility model is to provide a kind of aortic incompetence animal model making devices, existing to solve
Technical difficulty big, complicated for operation problem when having the production of aortic incompetence animal model.
The technical solution that the utility model solves above-mentioned technical problem is as follows:
A kind of aortic incompetence animal model making device, comprising: puncture needle, needle catheter, left ventricle are led
Pipe, aortic catheters and monitoring device；Needle catheter, left chamber tube and aortic catheters mutually interconnect along its length
It is connected into an entirety；Puncture needle runs through needle catheter；Left chamber tube includes the first feed liquor port and connects with monitoring device
The first connectivity port connect, aortic catheters include the second feed liquor port and the second connection end mouth that connect with monitoring device,
The needle outlet of needle catheter and the second feed liquor port are located at the lateral wall of left chamber tube.
Needle catheter, left chamber tube and aortic catheters are inserted into together in the artery of animal, and in arteria carotis
Middle movement, the blood in artery enters from needle outlet, the first feed liquor port or the second feed liquor port under the effect of the pressure respectively leads
Guan Zhong, monitoring device can convert electric signal for the pressure signal in left chamber tube and aortic catheters, and with pressure wave
Shape image and numerical value are shown in monitoring device.
When the first feed liquor port does not pass through aorta petal, monitoring device is shown in left chamber tube and aortic catheters
Pressure waveform image it is consistent；It is placed in left ventricle when the first feed liquor port passes through aorta petal mouth, and the second feed liquor port is still
When in aorta, monitoring device shows the blood pressure that the blood pressure in left chamber tube changes, in aortic catheters
It does not change.When the blood pressure difference in the blood pressure and aortic catheters in left chamber tube, stop movement, it will
Puncture needle is pierced by destruction aorta petal from needle outlet, and the variation of the pressure waveform image and numerical value that are shown by monitoring device confirms
Aortic incompetence.In addition, slight, moderate, severe can be made by the different variations of pressure waveform image and numerical value
Etc. degree aortic incompetence animal model.
The pressure waveform image and numerical value shown by monitoring device can quickly judge position locating for the bottom of each conduit
It sets, then aortic valve is destroyed by puncture needle, complete the production of animal model, integrated operation is simple, quick, operation difficulty
Low, technical difficulty is small.
Further, above-mentioned second feed liquor port and needle outlet are generally aligned in the same plane relative to the first feed liquor port.
Second feed liquor port and needle outlet are generally aligned in the same plane, prevent needle outlet from entering with the first feed liquor port
In left ventricle, puncture needle is avoided to destroy other tissues in left ventricle.Certainly, the second inlet can also be in needle outlet and first
Between inlet.
Further, the outer diameter that above-mentioned needle catheter goes out needle end is gradually reduced at inclined-plane.
Further, the outer diameter of above-mentioned left chamber tube liquid feeding end is gradually reduced.
Further, the outer diameter of above-mentioned aortic catheters liquid feeding end is gradually reduced at inclined-plane.
The outer diameter that needle catheter goes out needle end, left chamber tube liquid feeding end and aortic catheters liquid feeding end gradually subtracts
It is small, facilitate in each conduit insertion blood vessel.
Further, above-mentioned first connectivity port and second connection end mouth pass through tee tube respectively and are connected to monitoring device.
When making small animal model, the blood of toy is inadequate, can lead respectively to left ventricle from tee tube at this time
Saline injection in pipe and aortic catheters is full of left chamber tube and aortic catheters instead of blood, enables monitoring device
Enough accurate displays.
Further, above-mentioned puncture needle includes handpiece and the puncture needle ontology connecting with handpiece, puncture needle ontology
Through needle catheter, handpiece is placed in the entering on the outside of needle mouth of needle catheter.
Handpiece facilitates slides puncture needle in needle catheter, and the presence of handpiece can prevent puncture needle whole
It submerges in needle catheter.
Further, above-mentioned aortic incompetence animal model making device further include and enter needle mouth connection connection
Part；Puncture needle ontology through-connections and the sealing cooperation of puncture needle ontology and connector.
After puncture needle ontology and connector sealing cooperation, outwardly loss of the anti-Hemostatic Oral Liquid from needle catheter.
Further, above-mentioned aortic incompetence animal model making device further includes being connected by pipe and connector
The triple valve connect, triple valve are connected to by the deflector hole being set in connector with needle catheter.
The operations such as triple valve can be drawn blood, be vented, fluid injection.
Further, above-mentioned monitoring device includes energy converter and the display that is electrically connected with the energy converter, energy converter
It is connect respectively by extension tube with left chamber tube and aortic catheters.
Energy converter can convert electric signal for the pressure signal in left chamber tube and aortic catheters, then pass through display
The mode of the used pressure waveform image of device and numerical value is shown.
The utility model has the following beneficial effects:
The variation of pressure waveform image and numerical value that the utility model is shown by monitoring device, can determine the first feed liquor
Port and the second feed liquor port are the location of in the blood vessel.When the first feed liquor port passes through aortic valve, then by wearing
Puncture needle in pricker conduit destroys aortic valve, completes the production of animal model, integrated operation is simple, quick, operation
Difficulty is low, and technical difficulty is small and small to the wound of animal model, improves the survival rate of animal model.It is aobvious by monitoring device
The pressure waveform image and numerical value shown can determine the different variations of pressure in left chamber tube and aortic catheters, can make
Slightly, the aortic incompetence animal model of the degree such as moderate, severe.It is big in addition to that can make according to the size of device
Type animal model, moreover it is possible to make meiofauna model.
Detailed description of the invention
Fig. 1 is aortic incompetence animal model making device structural schematic diagram；
Fig. 2 is the aortic incompetence animal model making device A-A schematic diagram of Fig. 1.
In figure: 100- aortic incompetence animal model making device；110- puncture needle；111- handpiece；
112- puncture needle ontology；120- needle catheter；123- needle outlet；124- enters needle mouth；130- left chamber tube；133-
First feed liquor port；The first connectivity port 134-；140- aortic catheters；The second feed liquor of 143- port；144- second connects
Connect port；150- connector；160- triple valve；170- female Luer.
Specific embodiment
The principles of the present invention and feature are described below in conjunction with attached drawing, example is served only for explaining that this is practical
It is novel, it is not intended to limit the scope of the utility model.
Embodiment
Fig. 1 is please referred to, aortic incompetence animal model making device 100 includes puncture needle 110, needle catheter
120, left chamber tube 130, aortic catheters 140, connector 150, triple valve 160 and monitoring device.Needle catheter 120 with
The bottom surface of connector 150 connects, and 110 through-connections 150 of puncture needle and needle catheter 120, puncture needle 110 can connect
It is slided in part 150 and needle catheter 120.The material of connector 150 is rubber, when puncture needle 110 slides in connector 150
Cooperation can be sealed, prevents blood from flowing out.Needle catheter 120, left chamber tube 130 and aortic catheters 140 are along its length
Direction interconnects, and a channel of triple valve 160 is connect by pipe with the side of connector 150, triple valve 160
It is connected to by the L shape deflector hole inside connector 150 with needle catheter 120.In the other embodiments of the utility model, even
Fitting 150 can also be flexible plastics etc.；It can be not provided with triple valve 160 or be not provided with connector 150 and threeway
Valve 160, puncture needle 110 directly runs through needle catheter 120 at this time.
Puncture needle 110 includes handpiece 111 and puncture needle ontology 112.Handpiece 111 is placed in entering for needle catheter 120
124 outside of needle mouth and its sectional area are greater than the bore of needle catheter 120, prevent puncture needle 110 from submerging needle catheter 120
In.Puncture needle ontology 112 is stiff guide wire and can slide in needle catheter 120,112 one end of puncture needle ontology and hand-held
Part 111 connects, and the other end is tip, and tip can stretch out the needle outlet 123 of needle catheter 120.Needle catheter 120 goes out
The outer diameter at needle end gradually becomes smaller at inclined-plane.
Left chamber tube 130 includes the first feed liquor port 133 and the first connectivity port 134, and the first connectivity port 134 passes through
Female Luer 170 is connect with monitoring device.The outer diameter of 130 liquid feeding end of left chamber tube gradually becomes smaller.In its of the utility model
In its embodiment, it is provided with tee tube between female Luer 170 and monitoring device, physiological saline etc. can be transported to left ventricle
In conduit 130, prevent toy blood that cannot be full of when making small animal model full of left chamber tube 130 instead of blood
Left chamber tube 130, causes modelling to fail；Certainly, tee tube also can be set in the connecting pin of left chamber tube 130；
Female Luer 170 can also be set as threeway female Luer.
Aortic catheters 140 include the second feed liquor port 143 and second connection end mouth 144, and second connection end mouth 144 passes through
Female Luer 170 is connect with monitoring device.The outer diameter of 140 liquid feeding end of aortic catheters gradually becomes smaller.In its of the utility model
In its embodiment, it is provided with tee tube between female Luer 170 and monitoring device, physiological saline etc. can be transported to actively
In arteries and veins conduit 140, prevent toy blood from cannot fill when making small animal model full of aortic catheters 140 instead of blood
Full aortic catheters 140, cause modelling to fail；Certainly, the connection in aortic catheters 140 also can be set in tee tube
End；Female Luer 170 can also be set as threeway female Luer.
Needle catheter 120 goes out the lateral wall and aortic catheters of the lateral wall at needle end, 130 liquid feeding end of left chamber tube
The lateral wall of 140 liquid feeding ends interconnects and the second feed liquor port 143 and needle outlet 123 are relative to the first liquid feeding end
Mouth 133 is in approximately the same plane.In the other embodiments of the utility model, needle outlet 123 can also be in the first feed liquor port 133
And second between feed liquor port 143, the second feed liquor port 143 can also be between needle outlet 123 and the first feed liquor port 133.
Monitoring device includes energy converter and the display that is electrically connected with energy converter, and energy converter passes through extension tube and Rule
Connector 170 is connect with left chamber tube 130 and aortic catheters 140 respectively.
Referring to Fig.1 and 2, needle catheter 120, left chamber tube 130 and aortic catheters 140 it is rounded and
It interconnects, the region among each conduit is solid.In the other embodiments of the utility model, section of three conduits
Face is also possible to abnormity, and the monnolithic case after connection is circle, it is easier to be moved in the blood vessel.
It uses the process of above-mentioned apparatus production animal model as follows: (1) selecting animal right carotid artery for operative approach；
(2) operation on neck locality disinfection；(3) operative region longitudinally opens small notch, and dissociate arteria carotis, punctures arteria carotis；The present apparatus is inserted
Enter arteria carotis and moves in the artery.Pressure waveform image and numerical value on display are shown as left chamber tube 130 and active
When pressure in arteries and veins conduit 140 is consistent, the first feed liquor port 133 and the second feed liquor port 143 are respectively positioned in aorta；Continue to move
It is dynamic, until in the pressure and aortic catheters 140 that the pressure waveform image and numerical value of display are shown as in left chamber tube 130
Pressure is different, and the first feed liquor port 133 passes through aortic valve mouth at this time, and the second feed liquor port 143 is located at intra-arterial, fixes this
Device；(4) tip of puncture needle 110 is pierced by destruction aortic valve, pressure waveform image sum number from needle catheter 120
Value shows the pressure change in left chamber tube 130 and aortic catheters 140, determines aortic incompetence, that is, completes
The production of animal model.
The different variations that pressure in left chamber tube 130 and aortic catheters 140 is shown by display, can make light
The aortic incompetence animal model of the degree such as degree, moderate, severe.
The above is only the preferred embodiment of the present invention, is not intended to limit the utility model, all practical at this
Within novel spirit and principle, any modification, equivalent replacement, improvement and so on should be included in the guarantor of the utility model
Within the scope of shield.
Claims (10)
1. a kind of aortic incompetence animal model making device characterized by comprising puncture needle (110), puncture needle
Conduit (120), left chamber tube (130), aortic catheters (140) and monitoring device；The needle catheter (120), institute
It states left chamber tube (130) and the aortic catheters (140) is interconnected to an entirety along its length；The puncture
Needle (110) runs through the needle catheter (120)；The left chamber tube (130) include the first feed liquor port (133) and with
The first connectivity port (134) of the monitoring device connection, the aortic catheters (140) include the second feed liquor port (143)
And the second connection end mouth (144) being connect with the monitoring device, the needle outlet (123) of the needle catheter (120) and
Second feed liquor port (143) is located at the lateral wall of the left chamber tube (130).
2. aortic incompetence animal model making device according to claim 1, which is characterized in that described second
Feed liquor port (143) and the needle outlet (123) are generally aligned in the same plane relative to first feed liquor port (133).
3. aortic incompetence animal model making device according to claim 1, which is characterized in that the puncture
The outer diameter that wire guide (120) goes out needle end is gradually reduced at inclined-plane.
4. aortic incompetence animal model making device according to claim 1, which is characterized in that the left heart
The outer diameter of room conduit (130) liquid feeding end is gradually reduced.
5. aortic incompetence animal model making device according to claim 1, which is characterized in that the active
The outer diameter of arteries and veins conduit (140) liquid feeding end is gradually reduced at inclined-plane.
6. aortic incompetence animal model making device according to claim 1, which is characterized in that described first
Connectivity port (134) and the second connection end mouth (144) are connected to by tee tube with the monitoring device respectively.
7. aortic incompetence animal model making device according to claim 1, which is characterized in that the puncture
Needle (110) includes handpiece (111) and the puncture needle ontology (112) connecting with the handpiece (111), the puncture needle sheet
Body (112) runs through the needle catheter (120), and what the handpiece (111) was placed in the needle catheter (120) enters needle mouth
(124) outside.
8. aortic incompetence animal model making device according to claim 7, which is characterized in that further include with
It is described enter needle mouth (124) connection connector (150)；The puncture needle ontology (112) runs through the connector (150) and institute
Puncture needle ontology (112) and the connector (150) sealing is stated to cooperate.
9. aortic incompetence animal model making device according to claim 8, which is characterized in that further include leading to
The triple valve (160) that pipe is connect with the connector (150) is crossed, the triple valve (160) is by being set to the connector
(150) deflector hole in is connected to the needle catheter (120).
10. aortic incompetence animal model making device according to claim 1, which is characterized in that the prison
Measurement equipment includes energy converter and the display that is electrically connected with the energy converter, the energy converter pass through respectively extension tube with it is described
Left chamber tube (130) and the aortic catheters (140) connection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820123424.0U CN208770061U (en) | 2018-01-24 | 2018-01-24 | A kind of aortic incompetence animal model making device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820123424.0U CN208770061U (en) | 2018-01-24 | 2018-01-24 | A kind of aortic incompetence animal model making device |
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| Publication Number | Publication Date |
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| CN208770061U true CN208770061U (en) | 2019-04-23 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201820123424.0U Expired - Fee Related CN208770061U (en) | 2018-01-24 | 2018-01-24 | A kind of aortic incompetence animal model making device |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108403249A (en) * | 2018-01-24 | 2018-08-17 | 四川省人民医院 | A kind of aortic incompetence animal model making device |
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2018
- 2018-01-24 CN CN201820123424.0U patent/CN208770061U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108403249A (en) * | 2018-01-24 | 2018-08-17 | 四川省人民医院 | A kind of aortic incompetence animal model making device |
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| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20190423 Termination date: 20220124 |