CN108403249A - A kind of aortic incompetence animal model making device - Google Patents
A kind of aortic incompetence animal model making device Download PDFInfo
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- CN108403249A CN108403249A CN201810071157.1A CN201810071157A CN108403249A CN 108403249 A CN108403249 A CN 108403249A CN 201810071157 A CN201810071157 A CN 201810071157A CN 108403249 A CN108403249 A CN 108403249A
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- aortic
- needle
- animal model
- incompetence
- making device
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- 238000010171 animal model Methods 0.000 title claims abstract description 42
- 206010002915 Aortic valve incompetence Diseases 0.000 title claims abstract description 38
- 201000002064 aortic valve insufficiency Diseases 0.000 title claims abstract description 38
- 238000012806 monitoring device Methods 0.000 claims abstract description 27
- 239000007788 liquid Substances 0.000 claims description 13
- 210000001367 artery Anatomy 0.000 claims description 5
- 238000007789 sealing Methods 0.000 claims description 3
- 210000003462 vein Anatomy 0.000 claims description 2
- 238000005259 measurement Methods 0.000 claims 1
- 208000031873 Animal Disease Models Diseases 0.000 abstract description 2
- 238000011558 animal model by disease Methods 0.000 abstract description 2
- 230000004083 survival effect Effects 0.000 abstract description 2
- 210000000709 aorta Anatomy 0.000 description 15
- 239000008280 blood Substances 0.000 description 12
- 210000004369 blood Anatomy 0.000 description 12
- 210000001765 aortic valve Anatomy 0.000 description 9
- 210000005240 left ventricle Anatomy 0.000 description 8
- 241001465754 Metazoa Species 0.000 description 5
- 230000002861 ventricular Effects 0.000 description 5
- 230000036772 blood pressure Effects 0.000 description 4
- 210000004204 blood vessel Anatomy 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 230000003205 diastolic effect Effects 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 238000013459 approach Methods 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 206010007559 Cardiac failure congestive Diseases 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 206010037423 Pulmonary oedema Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 238000002583 angiography Methods 0.000 description 1
- 230000001194 anti-hemostatic effect Effects 0.000 description 1
- -1 be vented Substances 0.000 description 1
- 206010007625 cardiogenic shock Diseases 0.000 description 1
- 238000013155 cardiography Methods 0.000 description 1
- 210000001715 carotid artery Anatomy 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229920002457 flexible plastic Polymers 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000001361 intraarterial administration Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 208000005333 pulmonary edema Diseases 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D1/00—Surgical instruments for veterinary use
Abstract
The invention discloses a kind of aortic incompetence animal model making devices, belong to animal disease model technical field.Aortic incompetence animal model making device includes：Puncture needle, needle catheter, left chamber tube, aortic catheters and monitoring device.Puncture needle runs through needle catheter, needle catheter, left chamber tube and aortic catheters interconnect, and monitoring device is connect with left chamber tube and aortic catheters respectively and monitoring device can convert the pressure signal in left chamber tube and aortic catheters to waveform image and numerical value.The aortic incompetence animal model making device integrated operation of the present invention is simple, quick, operation difficulty is low, technical difficulty is small and small to the wound of animal model, the survival rate of animal model is improved, the large size or meiofauna model of different degrees of aortic incompetence can be additionally made by this device.
Description
Technical field
The present invention relates to animal disease model technical fields, and in particular to a kind of aortic incompetence animal model system
Make device.
Background technology
Aortic incompetence is also known as aortic regurgitation, is a kind of heart disease that clinic is common.Aorta petal position
Between left ventricle and aorta, Normal aorta valve is trilobed structure, and ventricular systole aorta petal is opened, and left ventricle is by blood
Liquid injects aorta, and ventricular diastole aortic valve closing prevents aorta blood from returning to left ventricle.When aorta petal structure is sent out
Changing or other reasons may result in aortic incompetence, and left ventricular diastolic blood is from aortic regurgitation to a left side
Ventricle.Aortic incompetence patients with mild may be asymptomatic；Middle severe patient is likely to occur left ventricular end diastolic presssure and increases, is left
The room effectively often amount of fighting decline, pulmonary edema, congestive heart failure, cardiogenic shock are even dead；Severe patient is possible therefore sudden
Extremely, threat to life.Therefore, occurring principle and treatment of the stable animal model for research aortic incompetence are established
Method is all of great significance.
Aortic incompetence animal model is mainly built by destroying, changing aortic valve or annulus structure at present
It is vertical, to influence the closure of left ventricular diastolic aorta petal.Wherein most by surgery or intervention surgical disruption aortic valve
Easily realize, using such method cause the approach of aortic incompetence it is main there are three：Surgical operation, X-ray guiding intervention
It is intervened with ultrasonic guidance.Surgical operation needs out chest to establish extracorporal circulatory system to destroy aorta petal under direct-view, and technology requires high, behaviour
Work is complicated, wound is big, animal easy infection, and mortality of animals is high.X-ray guiding intervention needs to monitor in digital subtraction angiography machine
Aortic valve is destroyed by special nipper down, technical difficulty is big, of high cost, and modelling personnel and animal are both needed to connect
It is radiated by X-ray.Ultrasonic guidance intervention need echocardiogram guiding in real time, to ultrasonic cardiography diagram technology and instrument and equipment have compared with
High request.
Invention content
The purpose of the present invention is to provide a kind of aortic incompetence animal model making devices, to solve existing master
Technical difficulty big, complicated for operation problem when arterial valve incompetence animal model makes.
The technical solution that the present invention solves above-mentioned technical problem is as follows：
A kind of aortic incompetence animal model making device, including：Puncture needle, needle catheter, left ventricle are led
Pipe, aortic catheters and monitoring device；Needle catheter, left chamber tube and aortic catheters mutually interconnect along its length
It is connected into an entirety；Puncture needle runs through needle catheter；Left chamber tube includes the first feed liquor port and connects with monitoring device
The first connectivity port connect, aortic catheters include the second feed liquor port and the second connection end mouth that is connect with monitoring device,
The needle outlet of needle catheter and the second feed liquor port are located at the lateral wall of left chamber tube.
Needle catheter, left chamber tube and aortic catheters are inserted into the artery of animal together, and in arteria carotis
Middle movement, the blood in artery enters from needle outlet, the first feed liquor port or the second feed liquor port under the effect of the pressure respectively leads
Guan Zhong, monitoring device can convert the pressure signal in left chamber tube and aortic catheters to electric signal, and with pressure wave
Shape image and numerical value are shown in monitoring device.
When the first feed liquor port does not pass through aorta petal, monitoring device is shown in left chamber tube and aortic catheters
Pressure waveform image it is consistent；When the first feed liquor port is placed in across aorta petal mouth in left ventricle, and the second feed liquor port is still
When in aorta, monitoring device shows that the blood pressure in left chamber tube changes, the blood pressure in aortic catheters
It does not change.When the blood pressure difference in the blood pressure and aortic catheters in left chamber tube, stop movement, it will
Puncture needle is pierced by destruction aorta petal from needle outlet, and the variation of the pressure waveform image and numerical value that are shown by monitoring device confirms
Aortic incompetence.In addition, changing by pressure waveform image and the different of numerical value, slight, moderate, severe can be made
Etc. degree aortic incompetence animal model.
The pressure waveform image and numerical value shown by monitoring device can quickly judge the position residing for the bottom of each conduit
It sets, then aortic valve is destroyed by puncture needle, complete the making of animal model, integrated operation is simple, quick, operation difficulty
Low, technical difficulty is small.
Further, above-mentioned second feed liquor port and needle outlet are generally aligned in the same plane relative to the first feed liquor port.
Second feed liquor port and needle outlet are generally aligned in the same plane, prevent needle outlet from being entered with the first feed liquor port
In left ventricle, puncture needle is avoided to destroy other tissues in left ventricle.Certainly, the second inlet can also be in needle outlet and first
Between inlet.
Further, above-mentioned needle catheter goes out the outer diameter at needle end and is gradually reduced at inclined-plane.
Further, the outer diameter of above-mentioned left chamber tube liquid feeding end is gradually reduced.
Further, the outer diameter of above-mentioned aortic catheters liquid feeding end is gradually reduced at inclined-plane.
The outer diameter that needle catheter goes out needle end, left chamber tube liquid feeding end and aortic catheters liquid feeding end gradually subtracts
It is small, facilitate each conduit to be inserted into blood vessel.
Further, above-mentioned first connectivity port and second connection end mouth are connected to by three-way pipe with monitoring device respectively.
When making small animal model, the blood of toy is inadequate, can be led respectively to left ventricle from three-way pipe at this time
Saline injection in pipe and aortic catheters is full of left chamber tube and aortic catheters instead of blood, enables monitoring device
Enough accurate displays.
Further, above-mentioned puncture needle includes handpiece and the puncture needle ontology being connect with handpiece, puncture needle ontology
Through needle catheter, handpiece is placed in the entering on the outside of needle mouth of needle catheter.
Handpiece facilitates slides puncture needle in needle catheter, and the presence of handpiece can prevent puncture needle whole
It submerges in needle catheter.
Further, above-mentioned aortic incompetence animal model making device further include and enter needle mouth connection connection
Part；Puncture needle ontology through-connections and puncture needle ontology and connector sealing cooperation.
After puncture needle ontology and connector sealing cooperation, outwardly loss of the anti-Hemostatic Oral Liquid from needle catheter.
Further, above-mentioned aortic incompetence animal model making device further includes being connected by pipe and connector
The triple valve connect, triple valve are connected to by the deflector hole being set in connector with needle catheter.
The operations such as triple valve can be drawn blood, be vented, fluid injection.
Further, above-mentioned monitoring device includes energy converter and the display that is electrically connected with the energy converter, energy converter
It is connect respectively with left chamber tube and aortic catheters by extension tube.
Energy converter can convert the pressure signal in left chamber tube and aortic catheters to electric signal, then pass through display
The mode of the used pressure waveform image of device and numerical value is shown.
The invention has the advantages that：
The variation for the pressure waveform image and numerical value that the present invention is shown by monitoring device, it may be determined that the first feed liquor port
And second feed liquor port the location of in the blood vessel.When the first feed liquor port passes through aortic valve, then pass through puncture needle
Puncture needle in conduit destroys aortic valve, completes the making of animal model, integrated operation is simple, quick, operation difficulty
Low, technical difficulty is small and small to the wound of animal model, improves the survival rate of animal model.It is shown by monitoring device
Pressure waveform image and numerical value can determine the different variations of pressure in left chamber tube and aortic catheters, can make light
The aortic incompetence animal model of the degree such as degree, moderate, severe.According to the size of device, in addition to large size can be made
Animal model, moreover it is possible to make meiofauna model.
Description of the drawings
Fig. 1 is aortic incompetence animal model making device structural schematic diagram；
Fig. 2 is the aortic incompetence animal model making device A-A schematic diagrames of Fig. 1.
In figure：100- aortic incompetence animal model making devices；110- puncture needles；111- handpieces；
112- puncture needle ontologies；120- needle catheters；123- needle outlets；124- enters needle mouth；130- left chamber tubes；133-
First feed liquor port；The first connectivity ports 134-；140- aortic catheters；The second feed liquors of 143- port；144- second connects
Connect port；150- connectors；160- triple valves；170- female Luers.
Specific implementation mode
The principle and features of the present invention will be described below with reference to the accompanying drawings, and the given examples are served only to explain the present invention, and
It is non-to be used to limit the scope of the present invention.
Embodiment
Fig. 1 is please referred to, aortic incompetence animal model making device 100 includes puncture needle 110, needle catheter
120, left chamber tube 130, aortic catheters 140, connector 150, triple valve 160 and monitoring device.Needle catheter 120 with
The bottom surface of connector 150 connects, and 110 through-connections 150 of puncture needle and needle catheter 120, puncture needle 110 can connect
It is slided in part 150 and needle catheter 120.The material of connector 150 is rubber, when puncture needle 110 slides in connector 150
Cooperation can be sealed, prevents blood from flowing out.Needle catheter 120, left chamber tube 130 and aortic catheters 140 are along its length
Direction interconnects, and a channel of triple valve 160 is connect by pipe with the side of connector 150, triple valve 160
It is connected to needle catheter 120 by the L-shaped deflector hole inside connector 150.In other embodiments of the invention, connector
150 can also be flexible plastics etc.；It can be not provided with triple valve 160 or be not provided with connector 150 and triple valve
160, puncture needle 110 is directly through needle catheter 120 at this time.
Puncture needle 110 includes handpiece 111 and puncture needle ontology 112.Handpiece 111 is placed in entering for needle catheter 120
124 outside of needle mouth and its sectional area are more than the bore of needle catheter 120, prevent puncture needle 110 from submerging needle catheter 120
In.Puncture needle ontology 112 is stiff guide wire and can be slided in needle catheter 120,112 one end of puncture needle ontology with it is hand-held
Part 111 connects, and the other end is tip, and tip can stretch out the needle outlet 123 of needle catheter 120.Needle catheter 120 goes out
The outer diameter at needle end is tapered at inclined-plane.
Left chamber tube 130 includes the first feed liquor port 133 and the first connectivity port 134, and the first connectivity port 134 passes through
Female Luer 170 is connect with monitoring device.The outer diameter of 130 liquid feeding end of left chamber tube tapers into.In other realities of the present invention
It applies in example, three-way pipe is provided between female Luer 170 and monitoring device, physiological saline etc. can be transported to left chamber tube
In 130, prevent toy blood that cannot be full of the left heart when making small animal model full of left chamber tube 130 instead of blood
Room conduit 130, causes modelling to fail；Certainly, three-way pipe can also be arranged in the connecting pin of left chamber tube 130；May be used also
Female Luer 170 is set as threeway female Luer.
Aortic catheters 140 include the second feed liquor port 143 and second connection end mouth 144, and second connection end mouth 144 passes through
Female Luer 170 is connect with monitoring device.The outer diameter of 140 liquid feeding end of aortic catheters tapers into.In other realities of the present invention
It applies in example, three-way pipe is provided between female Luer 170 and monitoring device, physiological saline etc. can be transported to aorta and led
In pipe 140, aortic catheters 140 are full of instead of blood, when making small animal model, prevent toy blood that cannot be full of master
Arterial duct 140, causes modelling to fail；Certainly, three-way pipe can also be arranged in the connecting pin of aortic catheters 140；Also
Female Luer 170 can be set as threeway female Luer.
Needle catheter 120 goes out the lateral wall and aortic catheters of the lateral wall at needle end, 130 liquid feeding end of left chamber tube
The lateral wall of 140 liquid feeding ends interconnects and the second feed liquor port 143 and needle outlet 123 are relative to the first liquid feeding end
Mouth 133 is in approximately the same plane.In other embodiments of the invention, needle outlet 123 can also be in the first feed liquor port 133 and
Between two feed liquor ports 143, the second feed liquor port 143 can also be between needle outlet 123 and the first feed liquor port 133.
Monitoring device includes energy converter and the display that is electrically connected with energy converter, and energy converter passes through extension tube and Rule
Connector 170 is connect with left chamber tube 130 and aortic catheters 140 respectively.
Referring to Fig.1 and 2, needle catheter 120, left chamber tube 130 and aortic catheters 140 it is rounded and
It interconnects, the region among each conduit is solid.In other embodiments of the invention, the section of three conduits
Can be abnormity, the monnolithic case after connection is circle, it is easier to be moved in the blood vessel.
The process that animal model is made of above-mentioned apparatus is as follows：(1) select animal right carotid artery for operative approach；
(2) operation on neck locality disinfection；(3) operative region longitudinally opens small notch, and dissociate arteria carotis, punctures arteria carotis；The present apparatus is inserted
Enter arteria carotis and moves in the artery.Pressure waveform image and numerical value on display are shown as left chamber tube 130 and active
When pressure in arteries and veins conduit 140 is consistent, the first feed liquor port 133 and the second feed liquor port 143 are respectively positioned in aorta；Continue to move
It is dynamic, until in the pressure and aortic catheters 140 that the pressure waveform image and numerical value of display are shown as in left chamber tube 130
Pressure is different, and the first feed liquor port 133 passes through aortic valve mouth, the second feed liquor port 143 to be located at intra-arterial at this time, fixes this
Device；(4) tip of puncture needle 110 is pierced by destruction aortic valve, pressure waveform image sum number from needle catheter 120
Value shows the pressure change in left chamber tube 130 and aortic catheters 140, determines aortic incompetence, that is, completes
The making of animal model.
The different variations that pressure in left chamber tube 130 and aortic catheters 140 is shown by display, can make light
The aortic incompetence animal model of the degree such as degree, moderate, severe.
The foregoing is merely presently preferred embodiments of the present invention, is not intended to limit the invention, it is all the present invention spirit and
Within principle, any modification, equivalent replacement, improvement and so on should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of aortic incompetence animal model making device, which is characterized in that including：Puncture needle (110), puncture needle
Conduit (120), left chamber tube (130), aortic catheters (140) and monitoring device；The needle catheter (120), institute
It states left chamber tube (130) and the aortic catheters (140) is interconnected to an entirety along its length；The puncture
Needle (110) runs through the needle catheter (120)；The left chamber tube (130) include the first feed liquor port (133) and with
The first connectivity port (134) of the monitoring device connection, the aortic catheters (140) include the second feed liquor port (143)
And the second connection end mouth (144) being connect with the monitoring device, the needle outlet (123) of the needle catheter (120) and
Second feed liquor port (143) is located at the lateral wall of the left chamber tube (130).
2. aortic incompetence animal model making device according to claim 1, which is characterized in that described second
Feed liquor port (143) and the needle outlet (123) are generally aligned in the same plane relative to first feed liquor port (133).
3. aortic incompetence animal model making device according to claim 1, which is characterized in that the puncture
The outer diameter that wire guide (120) goes out needle end is gradually reduced at inclined-plane.
4. aortic incompetence animal model making device according to claim 1, which is characterized in that the left heart
The outer diameter of room conduit (130) liquid feeding end is gradually reduced.
5. aortic incompetence animal model making device according to claim 1, which is characterized in that the active
The outer diameter of arteries and veins conduit (140) liquid feeding end is gradually reduced at inclined-plane.
6. aortic incompetence animal model making device according to claim 1, which is characterized in that described first
Connectivity port (134) and the second connection end mouth (144) are connected to by three-way pipe with the monitoring device respectively.
7. aortic incompetence animal model making device according to claim 1, which is characterized in that the puncture
Needle (110) includes handpiece (111) and the puncture needle ontology (112) being connect with the handpiece (111), the puncture needle sheet
Body (111) runs through the needle catheter (120), and what the handpiece (111) was placed in the needle catheter (120) enters needle mouth
(124) outside.
8. aortic incompetence animal model making device according to claim 7, which is characterized in that further include with
It is described enter needle mouth (124) connection connector (150)；The puncture needle ontology (112) runs through the connector (150) and institute
Puncture needle ontology (112) is stated with the connector (150) sealing to coordinate.
9. aortic incompetence animal model making device according to claim 8, which is characterized in that further include leading to
The triple valve (160) that pipe is connect with the connector (150) is crossed, the triple valve (160) is by being set to the connector
(150) deflector hole in is connected to the needle catheter (120).
10. aortic incompetence animal model making device according to claim 1, which is characterized in that the prison
Measurement equipment includes energy converter and the display that is electrically connected with the energy converter, the energy converter respectively by extension tube with it is described
Left chamber tube (130) and the aortic catheters (140) connection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810071157.1A CN108403249A (en) | 2018-01-24 | 2018-01-24 | A kind of aortic incompetence animal model making device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810071157.1A CN108403249A (en) | 2018-01-24 | 2018-01-24 | A kind of aortic incompetence animal model making device |
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| Publication Number | Publication Date |
|---|---|
| CN108403249A true CN108403249A (en) | 2018-08-17 |
Family
ID=63126427
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810071157.1A Pending CN108403249A (en) | 2018-01-24 | 2018-01-24 | A kind of aortic incompetence animal model making device |
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| CN202314878U (en) * | 2011-11-08 | 2012-07-11 | 高畅 | Three-cavity pigtail catheter |
| CN103300938A (en) * | 2013-06-27 | 2013-09-18 | 中国医学科学院阜外心血管病医院 | Trans-atrial pathway atrioventricular valve regurgitation animal modeling device and method |
| CN203328838U (en) * | 2013-06-27 | 2013-12-11 | 中国医学科学院阜外心血管病医院 | Device for manufacturing atrioventricular valve regurgitation animal model through atriums |
| CN205268324U (en) * | 2016-01-27 | 2016-06-01 | 王浩 | Aortic regurgitation animal models making devices |
| US20160310699A1 (en) * | 2014-01-31 | 2016-10-27 | Cedars-Sinai Medical Center | Pigtail for optimal aortic valvular complex imaging and alignment |
| CN208770061U (en) * | 2018-01-24 | 2019-04-23 | 四川省人民医院 | A kind of aortic incompetence animal model making device |
-
2018
- 2018-01-24 CN CN201810071157.1A patent/CN108403249A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050203425A1 (en) * | 2004-03-10 | 2005-09-15 | Phil Langston | Coaxial dual lumen pigtail catheter |
| CN202314878U (en) * | 2011-11-08 | 2012-07-11 | 高畅 | Three-cavity pigtail catheter |
| CN103300938A (en) * | 2013-06-27 | 2013-09-18 | 中国医学科学院阜外心血管病医院 | Trans-atrial pathway atrioventricular valve regurgitation animal modeling device and method |
| CN203328838U (en) * | 2013-06-27 | 2013-12-11 | 中国医学科学院阜外心血管病医院 | Device for manufacturing atrioventricular valve regurgitation animal model through atriums |
| US20160310699A1 (en) * | 2014-01-31 | 2016-10-27 | Cedars-Sinai Medical Center | Pigtail for optimal aortic valvular complex imaging and alignment |
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