CN109527561A - It is a kind of with antifatigue and strengthen immunity function Chinese medicine and health food and preparation method thereof - Google Patents
It is a kind of with antifatigue and strengthen immunity function Chinese medicine and health food and preparation method thereof Download PDFInfo
- Publication number
- CN109527561A CN109527561A CN201811550060.5A CN201811550060A CN109527561A CN 109527561 A CN109527561 A CN 109527561A CN 201811550060 A CN201811550060 A CN 201811550060A CN 109527561 A CN109527561 A CN 109527561A
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese medicine
- health food
- preparation
- antifatigue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 41
- 238000002360 preparation method Methods 0.000 title claims abstract description 22
- 235000013402 health food Nutrition 0.000 title claims abstract description 21
- 230000002929 anti-fatigue Effects 0.000 title claims abstract description 13
- 230000036039 immunity Effects 0.000 title claims abstract description 13
- MUKYLHIZBOASDM-UHFFFAOYSA-N 2-[carbamimidoyl(methyl)amino]acetic acid 2,3,4,5,6-pentahydroxyhexanoic acid Chemical compound NC(=N)N(C)CC(O)=O.OCC(O)C(O)C(O)C(O)C(O)=O MUKYLHIZBOASDM-UHFFFAOYSA-N 0.000 claims abstract description 18
- 241000283026 Cervus elaphus Species 0.000 claims abstract description 18
- 240000000249 Morus alba Species 0.000 claims abstract description 18
- 235000008708 Morus alba Nutrition 0.000 claims abstract description 18
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 18
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 18
- 244000046146 Pueraria lobata Species 0.000 claims abstract description 18
- 235000010575 Pueraria lobata Nutrition 0.000 claims abstract description 18
- 241001533104 Tribulus terrestris Species 0.000 claims abstract description 18
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 18
- 235000008434 ginseng Nutrition 0.000 claims abstract description 18
- 239000002994 raw material Substances 0.000 claims abstract description 11
- 238000000605 extraction Methods 0.000 claims description 46
- 239000000843 powder Substances 0.000 claims description 30
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 26
- 239000006071 cream Substances 0.000 claims description 22
- 241000208340 Araliaceae Species 0.000 claims description 17
- 235000019441 ethanol Nutrition 0.000 claims description 13
- 239000000463 material Substances 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 11
- 239000002775 capsule Substances 0.000 claims description 7
- 239000002552 dosage form Substances 0.000 claims description 4
- 239000008187 granular material Substances 0.000 claims description 3
- 238000001291 vacuum drying Methods 0.000 claims description 2
- 241000699666 Mus <mouse, genus> Species 0.000 abstract description 16
- 230000009182 swimming Effects 0.000 abstract description 12
- 241000699670 Mus sp. Species 0.000 abstract description 11
- 206010020751 Hypersensitivity Diseases 0.000 abstract description 5
- 208000026935 allergic disease Diseases 0.000 abstract description 5
- 230000007815 allergy Effects 0.000 abstract description 5
- 230000003111 delayed effect Effects 0.000 abstract description 5
- 230000002949 hemolytic effect Effects 0.000 abstract description 5
- 210000002966 serum Anatomy 0.000 abstract description 3
- 244000131316 Panax pseudoginseng Species 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 15
- 238000012360 testing method Methods 0.000 description 10
- 229920002472 Starch Polymers 0.000 description 9
- 229940079593 drug Drugs 0.000 description 9
- 239000000243 solution Substances 0.000 description 9
- 235000019698 starch Nutrition 0.000 description 9
- 230000000052 comparative effect Effects 0.000 description 7
- 239000004615 ingredient Substances 0.000 description 7
- 239000002904 solvent Substances 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- TZJALUIVHRYQQB-XFDQAQKOSA-N Icariin Natural products O(C)c1ccc(C2=C(O[C@H]3[C@@H](O)[C@H](O)[C@@H](O)[C@H](C)O3)C(=O)c3c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O4)c(C/C=C(\C)/C)c3O2)cc1 TZJALUIVHRYQQB-XFDQAQKOSA-N 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 5
- 239000000470 constituent Substances 0.000 description 5
- 238000011049 filling Methods 0.000 description 5
- TZJALUIVHRYQQB-XLRXWWTNSA-N icariin Chemical compound C1=CC(OC)=CC=C1C1=C(O[C@H]2[C@@H]([C@H](O)[C@@H](O)[C@H](C)O2)O)C(=O)C2=C(O)C=C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)C(CC=C(C)C)=C2O1 TZJALUIVHRYQQB-XLRXWWTNSA-N 0.000 description 5
- TZJALUIVHRYQQB-UHFFFAOYSA-N icariine Natural products C1=CC(OC)=CC=C1C1=C(OC2C(C(O)C(O)C(C)O2)O)C(=O)C2=C(O)C=C(OC3C(C(O)C(O)C(CO)O3)O)C(CC=C(C)C)=C2O1 TZJALUIVHRYQQB-UHFFFAOYSA-N 0.000 description 5
- 239000008107 starch Substances 0.000 description 5
- 238000004821 distillation Methods 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 238000004090 dissolution Methods 0.000 description 3
- 239000000741 silica gel Substances 0.000 description 3
- 229910002027 silica gel Inorganic materials 0.000 description 3
- 230000002411 adverse Effects 0.000 description 2
- 210000000170 cell membrane Anatomy 0.000 description 2
- 229940126678 chinese medicines Drugs 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 210000002683 foot Anatomy 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 210000002540 macrophage Anatomy 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000003826 tablet Substances 0.000 description 2
- 235000018553 tannin Nutrition 0.000 description 2
- 229920001864 tannin Polymers 0.000 description 2
- 239000001648 tannin Substances 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 206010018910 Haemolysis Diseases 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- VCUFZILGIRCDQQ-KRWDZBQOSA-N N-[[(5S)-2-oxo-3-(2-oxo-3H-1,3-benzoxazol-6-yl)-1,3-oxazolidin-5-yl]methyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C1O[C@H](CN1C1=CC2=C(NC(O2)=O)C=C1)CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F VCUFZILGIRCDQQ-KRWDZBQOSA-N 0.000 description 1
- 244000197580 Poria cocos Species 0.000 description 1
- 235000008599 Poria cocos Nutrition 0.000 description 1
- 240000003186 Stachytarpheta cayennensis Species 0.000 description 1
- 235000009233 Stachytarpheta cayennensis Nutrition 0.000 description 1
- 244000126002 Ziziphus vulgaris Species 0.000 description 1
- 210000002457 barrier cell Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001066 destructive effect Effects 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 230000012202 endocytosis Effects 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 230000002706 hydrostatic effect Effects 0.000 description 1
- 208000033065 inborn errors of immunity Diseases 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 210000001616 monocyte Anatomy 0.000 description 1
- 210000000822 natural killer cell Anatomy 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 208000028529 primary immunodeficiency disease Diseases 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
- A61K36/296—Epimedium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Immunology (AREA)
- Food Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Nutrition Science (AREA)
- Zoology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Developmental Biology & Embryology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of with antifatigue and strengthen immunity function Chinese medicine and health food, it is prepared from the following raw materials in parts by weight: 50-150 parts of cervus elaphus linnaeus；150-400 parts of Herba Epimedii；250-450 parts of puncture vine；150-400 parts of ginseng；150-400 parts of pueraria lobata；150-400 parts of mulberry fruit；150-400 parts of rhizoma polygonati, the invention also discloses preparation methods.The present invention can extend the mice burden swimming time, can enhance mouse antibodies cellulation number, improve mice serum half hemolytic value, improve mouse delayed allergy ability, therefore have the function of antifatigue and strengthen immunity.
Description
Technical field
It is a kind of with antifatigue and Chinese medicine and health food and its system of strengthen immunity function the invention belongs to pharmaceutical field
Preparation Method.
Background technique
With the raising and the accelerating rhythm of life of working efficiency, more and more people are chronically at the inferior health shape of fatigue
State leads to hypoimmunity, is easy to cause disease.It is protected for this purpose, occurring many antifatigue, strengthen immunity Chinese medicines in the market
Health food, but most products lack the support of theory of traditional Chinese medical science, prescription is not scientific, poor so as to cause health-care effect.In addition,
Existing health food remains in very due to lacking the system research to drug activity substance and the mechanism of action, preparation process
Level that is rough, falling behind, to not can guarantee efficacy and saferry.
Summary of the invention
It is more reasonable the purpose of the present invention is in view of the foregoing drawbacks, providing a kind of prescription, the more scientific tool of preparation process
There is antifatigue and strengthen immunity function Chinese medicine and health food, it is intended to improve efficacy and saferry.
Chinese medicine and health food provided by the invention is prepared from the following raw materials in parts by weight:
50-150 parts of cervus elaphus linnaeus；150-400 parts of Herba Epimedii；250-450 parts of puncture vine；150-400 parts of ginseng；Pueraria lobata 150-
400 parts；150-400 parts of mulberry fruit；150-400 parts of rhizoma polygonati.
Preferably, the Chinese medicine and health food is prepared from the following raw materials in parts by weight:
70-100 parts of cervus elaphus linnaeus；200-300 parts of Herba Epimedii；350-400 parts of puncture vine；200-300 parts of ginseng；Pueraria lobata 200-
300 parts；200-300 parts of mulberry fruit；200-300 parts of rhizoma polygonati.
Optimal, the Chinese medicine and health food is prepared from the following raw materials in parts by weight:
83 parts of cervus elaphus linnaeus；250 parts of Herba Epimedii；375 parts of puncture vine；250 parts of ginseng；250 parts of pueraria lobata；250 parts of mulberry fruit；Rhizoma polygonati
250 parts.
Preparation method provided by the invention the following steps are included:
1) cervus elaphus linnaeus, Herba Epimedii, puncture vine, ginseng, pueraria lobata, mulberry fruit, rhizoma polygonati are ground into 10-50 mesh coarse powder together, then
It is placed in ultra high pressure extraction container, the 40-80% ethyl alcohol of 5-20 times of weight is added, super-pressure is carried out under the conditions of 40-60 DEG C and is mentioned
It takes, the pressure of extraction is 300-600Mpa, and the time is 5-10 minutes, and number is 1-3 times；
2) extracting solution is concentrated in vacuo into thick paste, then by thick paste vacuum drying, crushing, dried cream powder is made；
3) auxiliary material is added into dried cream powder, the dosage form of suitable clinical use is made.
Preferably, the partial size of the coarse powder is 30 mesh.
Preferably, the ethyl alcohol is 60% ethyl alcohol.
Preferably, the temperature of the ultra high pressure extraction is 55 DEG C.
Preferably, the pressure is 500Mpa.
Preferably, the dosage form is capsule, tablet or granule.
Animal test results show: Chinese medicine and health food provided by the invention can extend the mice burden swimming time, can increase
Strong mouse antibodies cellulation number improves mice serum half hemolytic value, improves mouse delayed allergy ability, therefore have
There is antifatigue and strengthen immunity function.
Preparation method provided by the invention can increase icariin in drug, total saposins, total starches isoreactivity ingredients and contain
Amount, used is the superhigh pressure extracting method different from current most of Chinese medicine and health foods.Ultra high pressure extraction is also referred to as superelevation
Isostatic cool pressing is extracted, and is referred to the hydrostatic pressure of 100-1000MPa on the mixed liquor of Extraction solvent and Chinese medicine, and
A period of time is kept under predetermined pressure, and plant cell external and internal pressure is made to reach rapid release after balance.Since intraor extracellular permeates
Pressure increases suddenly, and the structure of cell membrane changes, and intracellular ingredient is enabled to pass through cell membrane and be transferred to cell
In outer extracting solution, achieve the purpose that extract traditional Chinese medicine ingredients.Compared with other extracting modes, ultra high pressure extraction also has temperature
Low, the advantages that time is short, high-efficient.
Specific embodiment
Embodiment 1
Cervus elaphus linnaeus 8.3Kg Herba Epimedii 25Kg puncture vine 37.5Kg ginseng 25Kg pueraria lobata 25Kg mulberry fruit 25Kg rhizoma polygonati 25Kg
Preparation method:
1) cervus elaphus linnaeus, Herba Epimedii, puncture vine, ginseng, pueraria lobata, mulberry fruit, rhizoma polygonati are ground into 30 mesh coarse powder together (referring to can passes through
The powder of 30 mesh screens), it is subsequently placed in ultra high pressure extraction container, 60% (weight, similarly hereinafter) ethyl alcohol of 15 times of weight is added, into
It is as follows to extract process for row ultra high pressure extraction:
Step 1: the pressure in extraction vessel is increased to 500Mpa, temperature is increased to 55 DEG C, is kept for 8 minutes；
Step 2: in seconds rapidly by the pressure pressure release in extraction vessel to normal pressure；
Step 3: filtering, collects extracting solution, 60% ethyl alcohol of 15 times of weight is added again into the dregs of a decoction, repeats the first step
It is operated with second step, makes total extraction time 2 times；
Step 4: filtering again, combined extract discards the dregs of a decoction.
2) then thick paste is dried in vacuo, crushes by the thick paste for being 1.32 at relative density by extracting solution vacuum-concentrcted,
Dried cream powder is made；
3) starch and superfine silica gel powder are added into dried cream powder, is then filled with capsule to get capsule.
Embodiment 2
Raw material is same as Example 1.
Preparation method:
1) cervus elaphus linnaeus, Herba Epimedii, puncture vine, ginseng, pueraria lobata, mulberry fruit, rhizoma polygonati are ground into 10 mesh coarse powder together (referring to can passes through
The powder of 10 mesh screens), it is subsequently placed in ultra high pressure extraction container, 50% ethyl alcohol of 20 times of weight is added, carry out super-pressure and mention
It takes, Extracting temperature is 60 DEG C, pressure 400Mpa, and the time is 10 minutes, and number is 3 times；
2) then thick paste is dried in vacuo, crushes by the thick paste for being 1.35 at relative density by extracting solution vacuum-concentrcted,
Dried cream powder is made；
3) microcrystalline cellulose and magnesium stearate are added into dried cream powder, granulation, tabletting is to get tablet.
Embodiment 3
Raw material is same as Example 1.
Preparation method:
1) cervus elaphus linnaeus, Herba Epimedii, puncture vine, ginseng, pueraria lobata, mulberry fruit, rhizoma polygonati are ground into 50 mesh coarse powder together, are subsequently placed in
In ultra high pressure extraction container, 70% ethyl alcohol of 12 times of weight is added, carries out ultra high pressure extraction, Extracting temperature is 45 DEG C, and pressure is
600Mpa, time are 6 minutes, and number is 1 time；
2) then thick paste is dried in vacuo, crushes by the thick paste for being 1.30 at relative density by extracting solution vacuum-concentrcted,
Dried cream powder is made；
3) Icing Sugar, dextrin are added into dried cream powder, pelletizes to get granule.
Embodiment 4
Raw material is same as Example 1.
Preparation method:
1) cervus elaphus linnaeus, Herba Epimedii, puncture vine, ginseng, pueraria lobata, mulberry fruit, rhizoma polygonati are ground into 20 mesh coarse powder together, are subsequently placed in
In ultra high pressure extraction container, 80% ethyl alcohol of 6 times of weight is added, carries out ultra high pressure extraction, Extracting temperature is 50 DEG C, and pressure is
300Mpa, time are 10 minutes, and number is 2 times；
2) then thick paste is dried in vacuo, crushes by the thick paste for being 1.32 at relative density by extracting solution vacuum-concentrcted,
Dried cream powder is made；
3) be added starch and superfine silica gel powder in phase dried cream powder, granulation, then with capsule fill to get.
Embodiment 5
Raw material is same as Example 1.
Preparation method:
1) cervus elaphus linnaeus, Herba Epimedii, puncture vine, ginseng, pueraria lobata, mulberry fruit, rhizoma polygonati are ground into 40 mesh coarse powder together, are subsequently placed in
In ultra high pressure extraction container, 40% ethyl alcohol of 18 times of weight is added, carries out ultra high pressure extraction, Extracting temperature is 40 DEG C, and pressure is
450Mpa, time are 5 minutes, and number is 2 times；
2) then thick paste is dried in vacuo, crushes by the thick paste for being 1.32 at relative density by extracting solution vacuum-concentrcted,
Dried cream powder is made；
3) starch and superfine silica gel powder are added into dried cream powder, is then filled with capsule to get capsule.
Test example 1
The dried cream powder weighing that embodiment 1-5 step 2) is obtained, calculates paste-forming rate and (refers to that dry cream total weight accounts for medicinal material total weight
Percentage), paste-forming rate be measure traditional Chinese medicine extraction efficiency an important indicator, usual paste-forming rate is higher, and extraction efficiency is bigger,
Preparation total amount made from identical medicinal material inventory is also higher, and production cost is lower.
Also the content of main active icariin in dried cream powder, total saposins, total starches is determined simultaneously.It is living
Property ingredient content directly determine the drug effect of Chinese medicine, only with paste-forming rate be only to investigate in the investigation of traditional Chinese medicine extraction effect
Index be it is very unilateral, the content of paste-forming rate height not necessarily active constituent is also high, and the extraction paste-forming rate of opposite many Chinese medicines is high
Caused by being primarily due to impurity mostly.Therefore, only integrated survey paste-forming rate and active component content comprehensively, could be commented objectively
Valence traditional Chinese medicine extraction effect.It the results are shown in Table 1.
The paste-forming rate and active component content that 1 Different Extraction Method of table obtains
| Test example | Paste-forming rate (%) | Icariin content (%) | Total saponin content (%) | Total starches content (%) |
| Embodiment 1 | 15.7 | 0.24 | 1.6 | 5.8 |
| Embodiment 2 | 16.1 | 0.21 | 1.7 | 5.4 |
| Embodiment 3 | 14.7 | 0.18 | 1.9 | 5.5 |
| Embodiment 4 | 15.2 | 0.22 | 1.5 | 5.1 |
| Embodiment 5 | 15.0 | 0.19 | 1.4 | 5.7 |
| Comparative example 1 | 14.6 | 0.11 | 0.9 | 4.2 |
| Comparative example 2 | 18.3 | 0.06 | 0.5 | 5.3 |
Note: comparative example 1 is to mention the medicinal material of prescription same as Example 1 according to conventional hot reflow method with 60% ethyl alcohol
Take simultaneously manufactured dry cream；Comparative example 2 is to extract the medicinal material water of prescription same as Example 1 simultaneously according to conventional decocting method
Manufactured dry cream.
Interpretation of result: (1) using paste-forming rate as inspection target, water boiling and extraction effect is best, this is also the current overwhelming majority
The reason in part for Chinese medicine all uses decocting to extract, mainly since decocting extraction makes medicinal material, histocyte is broken under the high temperature conditions
It splits, a large amount of structural constituent dissolutions make caused by the invalid components content increase such as fiber in extract, albumen, tannin, starch.From table
It can also be seen that icariin, the content of two kinds of main actives of total saposins are obviously relatively low in water decoction extract in middle result,
Comprehensive extraction effect is worst instead.
(2) ultra high pressure extraction is compared with circumfluence distillation, it can be found that the paste-forming rate of ultra high pressure extraction is slightly above
Circumfluence distillation, active component content are apparently higher than circumfluence distillation, this is because the principle of two kinds of extracting modes is entirely different
Caused, circumfluence distillation is merely by infiltration, the dissolution equilibrium of solvent to achieve the purpose that traditional Chinese medicine ingredients are extracted, herein
In the process, the destructive rate of medicinal material institutional framework is very low.
(3) in ultra high pressure extraction, medicinal material partial size, the concentration of Extraction solvent and dosage, Extracting temperature, pressure, the time and
Number has very crucial influence to extraction effect, for example, medicinal material partial size is smaller, solvent more readily penetrates through medicinal material tissue barrier
Cell is penetrated into, increases extraction efficiency to increase contact of the active constituent with solvent, but partial size is too small and can make medicinal material
The impurity components such as fiber, tannin in tissue excessively dissolve out, and have an adverse effect instead to extraction effect.It is real in embodiment 1-5
The synthesis extraction effect for applying example 1 is relatively more preferable.
(4) existing numerous studies have reported ultra high pressure extraction and can be improved the extraction efficiency and active constituent of Chinese medicine at present
Content still, but still has to be selected for specific kind, otherwise will not only improve extraction efficiency, instead may
Can have an adverse effect to extraction effect, such as Poria cocos, fructus lycii, this kind of Chinese medicine rich in starch, pectin of jujube, use
This method extraction will lead to a large amount of invalid element dissolutions, and will not only improve can reduce active component content instead, while can also
Sieve is blocked, extracting solution is made to be difficult to separate.
(5) content of icariin, three kinds of total saposins, total starches active constituents has only been investigated in test example, and Chinese medicine is
By playing curative effect after multicomponent, the comprehensive synergistic effect of multiple target point, the content for only investigating one of or several ingredients is also ratio
More unilateral, in fact, since the time of ultra high pressure extraction very short (only a few minutes), temperature are very low (being no more than 60 DEG C),
Also it is very beneficial for the extraction of volatile component and heat-sensitive ingredients, to further increase the curative effect of drug.
The test of 2 anti-fatigue effect of test example
Male Kunming strain mice 40, weight 18-22g are taken, is randomly divided into four groups, every group 10, example 1 group and comparison
1,2 group of example according to the dosage of 2.4g/Kgbw (30 times that are equivalent to human body recommended dose), is given animal subject stomach-filling and is mentioned respectively
Dry cream after taking, adds distilled water to dissolve dry cream before stomach-filling, and control group gives isometric solvent.Daily stomach-filling is primary, continuously
30 days.
After last stomach-filling 30min, mouse is placed in swimming trunk went swimming, the depth of water about 30cm, 25 ± 1.0 DEG C of water temperature, rat-tail
The sheet lead of 5% weight of portion's load, record mouse is since the time swimming to death as walking weight load (s).When swimming
Between be measurement data, if tested group of swimming time is considerably longer than control group swimming time, and difference has conspicuousness (P < 0.05), can
Determine that the tested material plays the role of extending the mice burden swimming time.It the results are shown in Table 2.
Influence of 2 present invention of table to the mice burden swimming time
| Number of animals (only) | Swimming time (second) | |
| Control group | 10 | 341.3±132.3 |
| Embodiment 1 | 10 | 515.0±120.7* |
| Comparative example 1 | 10 | 485.3±136.6* |
| Comparative example 2 | 10 | 425.6±128.9 |
From the above test results, it can be seen that Chinese medicine provided by the invention can extend the mice burden swimming time, therefore have
There is antifatigue function, compared with the control group, embodiment 1 and comparative example 1 have significant difference (P < 0.05).
3 strengthen immunity function test of test example
Male Kunming strain mice 40, weight 18-22g are taken, four groups is randomly divided into, every group 10, embodiment group is divided into
Basic, normal, high three dosage, respectively 0.4g/Kgbw, 0.8g/Kgbw, 2.4g/Kgbw are respectively equivalent to human body and recommend agent
5,10,30 times of amount, stomach-filling after adding distilled water to dissolve the dry cream after extraction, control group give isometric solvent.It fills daily
Stomach is primary, and continuous 30 days.
Then following tests is carried out:
1) influence of the method detection drug to mouse delayed allergy (DTH) is thickened using vola pedis, the results are shown in Table 3.
Influence of 3 drug of table to mouse delayed allergy (DTH)
| Number of animals (only) | Swelling degree of the paw (mm) for 24 hours after injection | |
| Control group | 10 | 0.259±0.133 |
| Low dosage | 10 | 0.358±0.112 |
| Middle dosage | 10 | 0.433±0.116* |
| High dose | 10 | 0.410±0.151* |
2) antibody-producting cell detection is carried out using Jerne improves slide method, the results are shown in Table 4.
Influence of 4 drug of table to mouse antibodies cellulation number
3) half hemolytic value (HC50) measurement, the results are shown in Table 5.
5 drug of table is to mouse half hemolytic value (HC50) influence
| Number of animals (only) | Half hemolytic value | |
| Control group | 10 | 255.92±62.57 |
| Low dosage | 10 | 287.76±61.28 |
| Middle dosage | 10 | 320.91±37.22* |
| High dose | 10 | 315.35±55.75 |
The above result shows that the medicine of orally administration mouse 0.4g/Kgbw, 0.8g/Kgbw, 2.4g/Kgbw dosage
Object 30 days, compared with the control group, 0.8g/Kgbw dosage can enhance mouse antibodies cellulation number, improve mice serum half
Hemolysis value, 0.8g/Kgbw, 2.4g/Kgbw dosage can improve mouse delayed allergy ability, and difference has conspicuousness (P
<0.05).In addition, drug of the present invention is thin to mouse weight, spleen, thymus gland, monocytes/macrophages carbonic clearance ability, mouse macrophage
Endocytosis is bitten chicken red blood cell ability, the mouse lymphocyte conversion capability of ConA induction and NK cells in mice active matter and is significantly affected.
The drug is prompted to have the function of strengthen immunity.
Embodiment 6
Cervus elaphus linnaeus 150g；Herba Epimedii 150g；Puncture vine 250g；Ginseng 150g；Pueraria lobata 150g；Mulberry fruit 150g；Rhizoma polygonati 150g.
Preparation method is same as Example 1.
Embodiment 7
Cervus elaphus linnaeus 50g；Herba Epimedii 400g；Puncture vine 450g；Ginseng 400g；Pueraria lobata 400g；Mulberry fruit 400g；Rhizoma polygonati 400g.
Preparation method is same as Example 1.
Embodiment 8
Cervus elaphus linnaeus 100g；Herba Epimedii 250g；Puncture vine 300g；Ginseng 300g；Pueraria lobata 300g；Mulberry fruit 200g；Rhizoma polygonati 200g.
Preparation method is same as Example 1.
Claims (9)
1. a kind of with antifatigue and strengthen immunity function Chinese medicine and health food, it is characterised in that by following weight proportion
Raw material is made:
50-150 parts of cervus elaphus linnaeus；150-400 parts of Herba Epimedii；250-450 parts of puncture vine；150-400 parts of ginseng；150-400 parts of pueraria lobata；
150-400 parts of mulberry fruit；150-400 parts of rhizoma polygonati.
2. as described in claim 1 with the Chinese medicine and health food of antifatigue and strengthen immunity function, it is characterised in that by with
The raw material of lower parts by weight is made:
70-100 parts of cervus elaphus linnaeus；200-300 parts of Herba Epimedii；350-400 parts of puncture vine；200-300 parts of ginseng；200-300 parts of pueraria lobata；
200-300 parts of mulberry fruit；200-300 parts of rhizoma polygonati.
3. as described in claim 1 with the Chinese medicine and health food of antifatigue and strengthen immunity function, it is characterised in that by with
The raw material of lower parts by weight is made:
83 parts of cervus elaphus linnaeus；250 parts of Herba Epimedii；375 parts of puncture vine；250 parts of ginseng；250 parts of pueraria lobata；250 parts of mulberry fruit；250 parts of rhizoma polygonati.
4. a kind of method for preparing any one of claim 1-3 Chinese medicine and health food, it is characterised in that including following step
It is rapid:
1) cervus elaphus linnaeus, Herba Epimedii, puncture vine, ginseng, pueraria lobata, mulberry fruit, rhizoma polygonati are ground into 10-50 mesh coarse powder together, are subsequently placed in
In ultra high pressure extraction container, the 40-80% ethyl alcohol of 5-20 times of weight is added, ultra high pressure extraction is carried out under the conditions of 40-60 DEG C, is mentioned
The pressure taken is 300-600Mpa, and the time is 5-10 minutes, and number is 1-3 times；
2) extracting solution is concentrated in vacuo into thick paste, then by thick paste vacuum drying, crushing, dried cream powder is made；
3) auxiliary material is added into dried cream powder, the dosage form of suitable clinical use is made.
5. the preparation method of Chinese medicine and health food as claimed in claim 4, it is characterised in that: the partial size of the coarse powder is 30 mesh.
6. the preparation method of Chinese medicine and health food as claimed in claim 4, it is characterised in that: the ethyl alcohol is 60% ethyl alcohol.
7. the preparation method of Chinese medicine and health food as claimed in claim 4, it is characterised in that: the temperature of the ultra high pressure extraction is
55℃。
8. the preparation method of Chinese medicine and health food as claimed in claim 4, it is characterised in that: the pressure is 500Mpa.
9. the preparation method of Chinese medicine and health food as claimed in claim 4, it is characterised in that: the dosage form is capsule, tablet
Or granule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811550060.5A CN109527561A (en) | 2018-12-18 | 2018-12-18 | It is a kind of with antifatigue and strengthen immunity function Chinese medicine and health food and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811550060.5A CN109527561A (en) | 2018-12-18 | 2018-12-18 | It is a kind of with antifatigue and strengthen immunity function Chinese medicine and health food and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109527561A true CN109527561A (en) | 2019-03-29 |
Family
ID=65855628
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811550060.5A Pending CN109527561A (en) | 2018-12-18 | 2018-12-18 | It is a kind of with antifatigue and strengthen immunity function Chinese medicine and health food and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109527561A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110140962A (en) * | 2019-06-06 | 2019-08-20 | 河北鲜合药业科技有限公司 | A kind of capsule of strengthen immunity and preparation method thereof |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1951222A (en) * | 2006-11-03 | 2007-04-25 | 深圳职业技术学院 | A health food for relieving fatigue and preparation method thereof |
| CN102526133A (en) * | 2012-03-05 | 2012-07-04 | 田爱华 | Pine needle extracts and preparation method thereof |
| CN102599595A (en) * | 2012-03-23 | 2012-07-25 | 柳华 | Health beverage with blood fat reducing function, traditional Chinese medicine and preparation method |
| CN102716272A (en) * | 2012-06-27 | 2012-10-10 | 乔树宏 | Traditional Chinese medicine composition for senescence delaying and antifatigue as well as soft capsule and preparation method of traditional Chinese medicine composition |
| CN104825791A (en) * | 2015-04-27 | 2015-08-12 | 湖北金鹰生物科技有限公司 | Fatigue-relieving traditional Chinese medicine health product and preparation method thereof |
| CN106387876A (en) * | 2016-08-31 | 2017-02-15 | 成都润馨堂药业有限公司 | Immunity enhancing and physical fatigue relieving health-care product recipe and preparation method thereof |
| CN106692473A (en) * | 2017-01-09 | 2017-05-24 | 上海寿叶生物科技有限公司 | Compound herbal preparation capable of relieving physical fatigue and resisting oxidation and preparation method thereof |
| CN108114239A (en) * | 2018-01-22 | 2018-06-05 | 武汉维奥制药有限公司 | A kind of capsule for increasing bone density and preparation method thereof |
| CN108339051A (en) * | 2018-05-03 | 2018-07-31 | 云南彝山天宝生物医药有限公司 | A kind of drug that treating chemical damage, preparation method and applications |
| CN108815378A (en) * | 2018-08-27 | 2018-11-16 | 山东国和堂制药有限公司 | It is a kind of for tonifying kidney and strengthening yang, alleviate the Chinese medicine composition and its production method and purposes of physical fatigue |
-
2018
- 2018-12-18 CN CN201811550060.5A patent/CN109527561A/en active Pending
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1951222A (en) * | 2006-11-03 | 2007-04-25 | 深圳职业技术学院 | A health food for relieving fatigue and preparation method thereof |
| CN102526133A (en) * | 2012-03-05 | 2012-07-04 | 田爱华 | Pine needle extracts and preparation method thereof |
| CN102599595A (en) * | 2012-03-23 | 2012-07-25 | 柳华 | Health beverage with blood fat reducing function, traditional Chinese medicine and preparation method |
| CN102716272A (en) * | 2012-06-27 | 2012-10-10 | 乔树宏 | Traditional Chinese medicine composition for senescence delaying and antifatigue as well as soft capsule and preparation method of traditional Chinese medicine composition |
| CN104825791A (en) * | 2015-04-27 | 2015-08-12 | 湖北金鹰生物科技有限公司 | Fatigue-relieving traditional Chinese medicine health product and preparation method thereof |
| CN106387876A (en) * | 2016-08-31 | 2017-02-15 | 成都润馨堂药业有限公司 | Immunity enhancing and physical fatigue relieving health-care product recipe and preparation method thereof |
| CN106692473A (en) * | 2017-01-09 | 2017-05-24 | 上海寿叶生物科技有限公司 | Compound herbal preparation capable of relieving physical fatigue and resisting oxidation and preparation method thereof |
| CN108114239A (en) * | 2018-01-22 | 2018-06-05 | 武汉维奥制药有限公司 | A kind of capsule for increasing bone density and preparation method thereof |
| CN108339051A (en) * | 2018-05-03 | 2018-07-31 | 云南彝山天宝生物医药有限公司 | A kind of drug that treating chemical damage, preparation method and applications |
| CN108815378A (en) * | 2018-08-27 | 2018-11-16 | 山东国和堂制药有限公司 | It is a kind of for tonifying kidney and strengthening yang, alleviate the Chinese medicine composition and its production method and purposes of physical fatigue |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110140962A (en) * | 2019-06-06 | 2019-08-20 | 河北鲜合药业科技有限公司 | A kind of capsule of strengthen immunity and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101152007B (en) | Health-care products composition and method for preparing the same | |
| CN101485796B (en) | Chinese medicinal composition for treating insomnia as well as preparation method thereof | |
| CN104825791B (en) | A kind of traditional Chinese medicine health care product with anti-fatigue effect and preparation method thereof | |
| CN102579669B (en) | Chinese medicinal composition for nourishing qi and blood and conditioning menstruation and preparation method thereof | |
| CN104784505B (en) | A kind of Dendrobium officinale health product of auxiliary hyperglycemic and preparation method thereof | |
| CN103623341A (en) | Drug for treating hypertension and cardiovascular and cerebrovascular diseases caused by hypertension | |
| CN101878906A (en) | Health care food with auxiliary hyperglycemic function and preparation method thereof | |
| CN108042716A (en) | A kind of traditional Chinese medicine preparation product of auxiliary hyperglycemic | |
| CN101244208B (en) | Method of preparing traditional Chinese medicine preparation for treating melancholia and anxiety neurosis | |
| CN109527561A (en) | It is a kind of with antifatigue and strengthen immunity function Chinese medicine and health food and preparation method thereof | |
| CN104489647A (en) | Anti-fatigue health food containing radix astragali, eucommia, rhizoma polygonati, sea-buckthorn and ginseng and preparation method thereof | |
| CN107156830A (en) | A kind of composition of strengthen immunity, its preparation method and application | |
| CN106474083A (en) | Peaceful no sugar chawing tablet and its preparation technology and the application of Fructus Lycii sugar | |
| CN101491568B (en) | Medicine combination capable of resisting fatigue and radiation hazard and preparation method thereof | |
| CN102293855A (en) | Chinese medicinal composition for treating speech and kidney deficiency diabetic nephropathy, and preparation method and application thereof | |
| CN104398588A (en) | Traditional Chinese medicine formula capable of nourishing kidney, boosting essence, strengthening brain and resisting fatigue and preparation method of traditional Chinese medicine formula | |
| CN115137770A (en) | Preparation method of traditional Chinese medicine product with efficacy of reducing blood fat and blood pressure | |
| CN101342313B (en) | Health care granular formulation, preparation and application thereof | |
| CN101185738A (en) | Gynaecologic inflammation rehabilitation effervescence granular preparation and confecting method thereof | |
| CN107213197A (en) | A kind of Chinese medicine composition and its application in prevention or treatment hypertension drug is prepared | |
| CN103417799A (en) | Applications of a traditional Chinese medicine composition in preparing medicines treating anaemia | |
| CN100484536C (en) | Capsule for treating enteritis and dysentery and its preparing process | |
| CN104983759A (en) | Traditional Chinese medicine composition treating diabetic nephropathy and preparing method thereof | |
| CN110664905A (en) | Traditional Chinese medicine preparation for expelling wind and clearing away cold and preparation method thereof | |
| CN102988757A (en) | Traditional Chinese medicine preparation used for treating diabetes mellitus |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190329 |
|
| RJ01 | Rejection of invention patent application after publication |