CN104398588A - Traditional Chinese medicine formula capable of nourishing kidney, boosting essence, strengthening brain and resisting fatigue and preparation method of traditional Chinese medicine formula - Google Patents
Traditional Chinese medicine formula capable of nourishing kidney, boosting essence, strengthening brain and resisting fatigue and preparation method of traditional Chinese medicine formula Download PDFInfo
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- CN104398588A CN104398588A CN201410677642.5A CN201410677642A CN104398588A CN 104398588 A CN104398588 A CN 104398588A CN 201410677642 A CN201410677642 A CN 201410677642A CN 104398588 A CN104398588 A CN 104398588A
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- chinese medicine
- extract
- cistanche tubulosa
- traditional chinese
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/64—Orobanchaceae (Broom-rape family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/254—Acanthopanax or Eleutherococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicine formula capable of nourishing the kidney, boosting the essence, strengthening the brain and resisting the fatigue. The traditional Chinese medicine is prepared from the following substances in parts by weight: 112-130 parts of cistanche tubulosa extracts, 105-120 parts of acanthopanax extracts, 50-72 parts of American ginseng extracts and 160-190 parts of microcrystalline cellulose. The invention further provides a preparation method of the traditional Chinese medicine formula. The traditional Chinese medicine disclosed by the invention has the benefits that the traditional Chinese medicine can effectively relieve physical fatigue, strengthen memory and loosen the bowel to relieve constipation, and is obvious in efficacy; the traditional Chinese medicine relieves physical fatigue, and improves and promotes the living quality of fatigable crowds; the traditional Chinese medicine is good in stability, non-toxic, and harmless and does not contain exciting and stimulating components; at the same time, the extraction process of cistanche tubulosa is optimized.
Description
Technical field
The present invention relates to the Chinese medicine formula and preparation method thereof of a kind of the kidney invigorating and essence nourishing, brain-strengthening, resisting fatigue.
Background technology
Fatigue refer to lasting or overworked after the uncomfortable and work efficiency that causes go down, main manifestations is tired sleepy, can occur degradation simultaneous phenomenon under dizziness, forgetful, sleep quality.The factor relations such as tired generation and energy substance consumption, metabolite are piled up, homeostasis sexual maladjustment, free radical impact are close.Fatigue is a kind of physiological phenomenon, concerning the mechanism people being a kind of protectiveness.This is that health sends the signal had a rest to us.If ignored to fatigue for a long time, CFS(chronic fatigue syndrome can be caused) generation.CFS is exactly the tired progressive result with accumulating, be modern efficient, occur under fast rhythm life style one group with the extremely tired general syndrome for main outstanding behaviours for a long time, its basic feature is extremely tired for a long time, can not alleviate after rest, and with a series of other somatization and cognitive disorder, as throat pain, memory disorder, absent minded, headache etc.Fatigue is a very common symptom, reports according to the study, and have the adult of 24% to have in the U.S. and continue 2 weeks or fatigue for more time, wherein the people of 59%-64% does not have obvious disease reason.The tired prevalence baseline of general population is about 20%, and athletics is as a kind of special occupation, and training and the match of long-time large amount of exercise all can produce sports fatigue.Community survey according to Australia shows: have 3.7 ten thousand people to suffer from chronic fatigue syndrome in general population, wherein 40% can not normal study and work.The eighties in 20th century, the investigation of the U.S. found, have the adult male of 14% and 20% women performance have obvious fatigue, wherein 1/8 develop into CFS (chronic fatigue syndrome), the investigation of 2001-2002 years then shows: have 12186 people to suffer from the confirmed fatigue at least continuing 6 months in 100,000 people, nearly 2,200,000 Americans have doubtful CFS.The investigation of Britain then shows that the male of nearly 20% and the women of 25% feel tired, and wherein about 1/4 may be CFS.In western countries, CFS is that people go one of five of hospital admission large reasons.It is reported, Japan is one of area that prevalence is the highest, and Japanese Department of Labor announced the Japanese whole nation in 2000 have the population in the length of service of 1/3 to suffer from CFS.The sickness rate of the CFS of China is also very high.The nonrandom sampling survey of 20 ~ 50 years old ordinarily resident in Hongkong, in 1013 investigation residents, what have fatigue symptom is that 585 people account for 57.8%, and meet 65 people of CFS diagnostic criteria, prevalence is 6.4%.Women's morbidity, higher than male, is Susceptible population.Age mainly concentrates on 31 ~ 50 years old.Blue-collar peasant is mainly engaged in occupation, the crowd of what schooling was higher be engaged in mental activity.Fatigue is the low or stable imbalance of immunologic function of the autoimmune function caused by long-term body and mind hypertonicity, continuously fatigue, the general performance that the reasons such as the low or suppression of function of nervous system cause, cause people worn out mentally and physically, work efficiency is low, with the passing of time then become sick it, have troubled dead possible, therefore the attention of society should be caused.But fatigue is a kind of physiology or pathological phenomenon, be still unlikely under general case to carry out being in hospital or Drug therapy as disease because of tired, therefore, the health food of alleviating physical fatigue is more suitable for the market demand.People more and more pay attention to quality of life now simultaneously, and health care consciousness is strengthened gradually, and therefore, the health food that exploitation has alleviating physical fatigue function has market prospect widely.
Alleviating physical fatigue product roughly can be divided into following a few class in the market:
First is makeup energy.Usually reached by the nutrition consumed in supplementary motion and maintain body normal physiological function, the object of relieving fatigue;
Second is vitamin and the trace element of supplementary needed by human;
3rd is the function of function, particularly blood circulation by improving biological organs, and the removing of acceleration bodies intracellular metabolite material, discharge, reach resisting fatigue object.
Consult national OTC official written reply storehouse, up to the present the product of alleviating physical fatigue function has about 1300; According to the Shanghai City Commercial Information Center first quarter in 2005 statistics display, seven large class health foods occupy the share of Shanghai City health food market 75%, wherein alleviating physical fatigue product with 23.2% the market share rank first.Visible this kind of health food has the market demand widely.
Summary of the invention
Object of the present invention is exactly for above-mentioned defect of the prior art, provide a kind of can the Chinese medicine formula of effectively the kidney invigorating and essence nourishing, brain-strengthening, resisting fatigue.
To achieve these goals, technical scheme provided by the invention is: the Chinese medicine formula of a kind of the kidney invigorating and essence nourishing, brain-strengthening, resisting fatigue, it is prepared by the following material according to parts by weight: Cistanche Tubulosa extract 112 ~ 130 parts, Radix Et Caulis Acanthopanacis Senticosi extract 105 ~ 120 parts, Radix Panacis Quinquefolii extract 50 ~ 72 parts, microcrystalline Cellulose 160 ~ 190 parts.
Further, above-mentioned a kind of the kidney invigorating and essence nourishing, brain-strengthening, the Chinese medicine formula of resisting fatigue, the leaching process of described Cistanche Tubulosa extract is: extracted twice by the Cistanche Tubulosa stem powder methanol eddy of 5.0kg drying, each 3 hours, be decompressed to vacuum 0.07 ~ 0.08MPa to concentrate, after solvent evaporated, obtain Cistanche Tubulosa-methanolic extract 1340 g, get wherein 160 g and carry out silica gel column chromatography, with chloroform-methanol-water gradient elution, through thin layer chromatography inspection, merge into 6 eluted fraction Fr.1 ~ Fr.6, after microwave vacuum drying, pulverize, in microwave-vacuum drying, vacuum is 0.07 ~ 0.08MPa, baking temperature is 60 DEG C, drying time is 6 ~ 8 hours.
Second object of the present invention there is provided the preparation method of Chinese medicine formula of above-mentioned a kind of the kidney invigorating and essence nourishing, brain-strengthening, resisting fatigue, comprises the following steps:
1) proportional quantity is taken after Cistanche Tubulosa extract being crossed 80 mesh sieves;
2) proportional quantity is taken after Radix Et Caulis Acanthopanacis Senticosi extract being crossed 80 mesh sieves;
3) proportional quantity is taken after Radix Panacis Quinquefolii extract being crossed 80 mesh sieves;
4) proportional quantity is taken after microcrystalline Cellulose being crossed 80 mesh sieves;
5) step 1)-step 4) is obtained sieve after the Cistanche Tubulosa extract of proportional quantity, Radix Et Caulis Acanthopanacis Senticosi extract, Radix Panacis Quinquefolii extract and microcrystalline Cellulose mix homogeneously, obtain mixed powder and be finished product.
Further, above-mentioned a kind of the kidney invigorating and essence nourishing, brain-strengthening, the preparation method of the Chinese medicine formula of resisting fatigue, it is characterized in that, the leaching process of the Cistanche Tubulosa extract in described step 1) is: extracted twice by the Cistanche Tubulosa stem powder methanol eddy of 5.0kg drying, each 3 hours, be decompressed to vacuum 0.07 ~ 0.08MPa to concentrate, after solvent evaporated, obtain Cistanche Tubulosa-methanolic extract 1340 g, get wherein 160 g and carry out silica gel column chromatography, with chloroform-methanol-water gradient elution, through thin layer chromatography inspection, merge into 6 eluted fraction Fr.1 ~ Fr.6, after microwave vacuum drying, pulverize, in microwave-vacuum drying, vacuum is 0.07 ~ 0.08MPa, baking temperature is 60 DEG C, drying time is 6 ~ 8 hours.
The Chinese medicine formula of the kidney invigorating and essence nourishing provided by the invention, brain-strengthening, resisting fatigue, the needs for fatiguability crowd, use theory of Chinese medical science, in conjunction with modern Chinese medicine pharmacological research achievement, with Herba Cistanches extract, Radix Et Caulis Acanthopanacis Senticosi extract, Radix Panacis Quinquefolii extract for primary raw material, be equipped with the health food with alleviating physical fatigue function that suitable adjuvant is processed into, improved the quality of life of fatiguability crowd by alleviating physical fatigue.
The Modern preparations technology such as this formula is sieved by employing, weigh, mix, soft material processed, granulation, drying, granulate, total mixed, tabletting, inner packing, outer package, inspection warehouse-in, in the Workshop Production by health food GMP certification, formulate rational method of quality control, and strict management of product measure, ensure that the steady quality of product, safe and reliable.This product confirms safe, nontoxic through the test of health food Toxicological evaluation, can long-term taking; The health care with alleviating physical fatigue is confirmed through animal function test; Confirm not add prohibited items through drug-testing test; Verify steady quality, controlled through hygiology, stability, functional component, dosage form is reasonable.
Beneficial effect of the present invention is:
1) with the biological product clear efficacy that the raw rare medicinal herbs of Novel sand is major ingredient, the world, domestic health industry is met to the market orientation of biological health goods and demand:
The health food regulated internal organs etc. based on Chinese medicine is subject to concern and the favor of people always, this product take natural plant extracts as primary raw material, through scientific compatibility, the health food with alleviating physical fatigue function made, has no side effect, be applicable to sub-health population, improve the health of sub-health population, play prevention of disease effect, improve the quality of life of people, after putting on market, vast potential for future development will be had.
2) high-quality herbaceous material traceability system is set up:
In the product of this Project-developing, major ingredient Cistanche Tubulosa is all from own standardization plantation farm, specifically set up the basic condition of traceability system, traceability system can realize all batch products from raw material to finished product, from finished product to raw material 100% two-way tracing function, the maximum featured function of this system is exactly the safety of data, and the link of each artificial input is all backed up in realtime by software.
3) use membrance separation purification by liquid extraction technology to carry out solidifying extraction to batching, realize Cistanche Tubulosa efficiency utilization:
This technology effectively can remove thalline, improves product content and purity; Separation condition is gentle, without phase-state change, be thus conducive to biological activity and the physical and chemical stability of preservation effective ingredient; Avoid allogenic material and affect the quality of effective ingredient; Without the need to adding solvent, simplifying production technology, shortening the production cycle, improve production security;
4) employing herbal essences multidimensional synthesis pressed-disc technique is produced:
Realize the additive-free tabletting of 100% pure powder, increase buccal, mucosal absorption new tunnel in mouth, ensure that herbaceous plant essential ingredient utilizes to maximize, directly enter blood circulation of human body, without the first pass effect of gastrointestinal tract and liver, efficient convenience, carry, transport, take all more convenient, be easy to consumer accept and take.
5) scientific composition, ensures science, reasonability that novel compatibility has:
The traditional Chinese medical science is thought, the appearance of fatigue phenomenon, has close relationship with the imbalance of the five internal organs, simultaneously, the traditional Chinese medical science is thought again, the whole vital movement of people, entirely relies in " vigour ", vigour natural endowment is in congenital and nourished the day after tomorrow, be the source of body energy, combine from different internal organs and just produce different functions, so vigour is weak, each function inhibitory state at a low ebb of human body will be made, also just constitute and produce tired basic reason.This product with Herba Cistanches extract, Radix Et Caulis Acanthopanacis Senticosi extract, Radix Panacis Quinquefolii extract for primary raw material.Through each raw material of inquiry this product not at the row of " eighteen incompatible medicaments ", " nineteen medicaments of mutual restraint ", without incompatibility; In formula, Herba Cistanches enters kidney channel, kidney-replenishing, benefiting essence-blood, the main marrow improving inspiration by invigorating kidney-QI of kidney storing essence, is people's the congenital foundation; Radix Et Caulis Acanthopanacis Senticosi enters spleen, kidney, heart channel, replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization, spleen transporting and transforming nutrients from foodstuff, is source of generating QI and blood, is people's the foundation of acquired constitution; Radix Panacis Quinquefolii boosting qi and nourishing yin, clearing away heat and promoting production of body fluid.Take a broad view of we, Herba Cistanches enters kidney channel, and the congenital foundation is grown, and Radix Et Caulis Acanthopanacis Senticosi i.e. the kidney invigorating but also spleen invigorating are also calmed the nerves, and the foundation of acquired constitution are mended, Radix Panacis Quinquefolii YIN nourishing and the production of body fluid promoting, three's compatibility, play effect of alleviating physical fatigue altogether.
Meanwhile, and entrust professional disease prevention and control center to carry out the zoopery of alleviating physical fatigue function in strict accordance with health food inspection and assessment technical specification to product, result of the test shows that this product has alleviating physical fatigue function.
Technical scheme provided by the invention also has the following advantages:
one, declare function according to the efficacy effect of Herba Cistanches and health food, develop the functional biological health food having and alleviate physical resisting fatigue, memory reinforcing, loosening bowel to relieve constipation, carried out scientific composition and compatibility:
1) screening of formula:
Screening technique: use alleviating physical fatigue, memory reinforcing, improve the method for inspection of intestinal health functional check method (zoopery: body weight, Loaned swimming test, blood lactase acid, serum urea, hepatic glycogen or muscle glycogen).
The selection result: product has alleviating physical fatigue, memory reinforcing, improves intestinal health function.
Screening foundation: " health food inspection and assessment technical specification " (version in 2010).
2) clear efficacy:
Product provided by the invention is the needs for fatiguability crowd, use theory of Chinese medical science, in conjunction with modern Chinese medicine pharmacological research achievement, with Herba Cistanches extract, Radix Et Caulis Acanthopanacis Senticosi extract, Radix Panacis Quinquefolii extract for primary raw material, be equipped with the health food with alleviating physical fatigue function that suitable adjuvant is processed into, improved the quality of life of fatiguability crowd by alleviating physical fatigue.
two, Cistanche Tubulosa chemical composition and bioactivity research:
Project is by cooperating with Xinjing Vygur Autonomous Region Chinese Medicine and Ethnic Medicine Research Inc., technical staff is appointed to carry out learning and communication to Xinjing Vygur Autonomous Region Chinese Medicine and Ethnic Medicine Research Inc., the Cistanche Tubulosa of South Sinkiang product is carried out to separation and the bioactivity research of chemical composition, be divided into from identifying 39 compounds from Cistanche Tubulosa, wherein noval chemical compound 9, known compound 10.In 9 noval chemical compounds, 2 is phenethyl alcohol glycosides, and 6 is monoterpene (glycosides) class.
Carry out extraction and isolation flow process: drying tube flower herba cistanches stem powder (5.0 kg) methanol eddy extracts twice, and each 3 hours, concentrating under reduced pressure solvent evaporated obtained methanolic extract 1340 g.Get wherein 160 g and carry out silica gel column chromatography, with chloroform-methanol-water gradient elution, through thin layer chromatography inspection, merge into 6 eluting stream parts (Fr.1 ~ Fr.6).
In biological activity research: project has carried out the research that Cistanche Tubulosa extract affects high salt raising rat blood pressure, erythrocyte membrane fluidity and whole blood viscosity.The contraction of Late Cambrian Cistanche Tubulosa methanolic extract to the isolated rat thoracic aorta that norepinephrine is induced has vasodilator effect; and determine that vasodilator effect effective ingredient is phenethyl alcohol glycoside compounds verbascoside (1), the echinacoside (2) of 4 bit strip coffee acyls of glucose, and acylated sugars pipe spends sugar (3), Cistanche Tubulosa glycosides F(4).
In the Hydrolysis kinetics of Cistanche Tubulosa effective ingredient: the screening of raw material, high energy-collecting ultrasonic ripple extraction, membrance separation, concentrated, drying, sterilizing, pulverize, sieve, check, pack, put all employing state-of-the-art technologies in storage and complete.
three, the research of the aspect such as the technique of product, quality standard and security related, stability, functional, hygiology:
1) screening of formula:
Screening technique: use alleviating physical fatigue, memory reinforcing, improve the method for inspection of intestinal health functional check method (zoopery: body weight, Loaned swimming test, blood lactase acid, serum urea, hepatic glycogen or muscle glycogen).
The selection result: product has alleviating physical fatigue, memory reinforcing, improves intestinal health function.
Screening foundation: " health food inspection and assessment technical specification " (version in 2003).
2) production technology of product:
The screening of raw material, high energy-collecting ultrasonic ripple extraction, membrance separation, concentrated, drying, sterilizing, pulverize, sieve, check, pack, put all most advanced production Technology of employing in storage and complete.Workshop is between 100,000 grades of medicine special-purpose vehicles.
3) formulation of target level of product quality: determine by health (functional) food universal standard GB16740 and relevant criterion.
4) detection method (mensuration of echinacoside, acteoside, total saponin content) of product efficacy composition:
Use LC-2010CHT type high performance liquid chromatograph, AE-140 type electronic balance; Chromatographic column: octadecylsilane chemically bonded silica is that the equipment such as the chromatographic column of filler measure.
5) Product Safety evaluation experimental method is pharmaceutical grade Demonstration Method:
Acute toxicity: select body weight to be the Kunming mouse of 18g ~ 22g, male and female half and half are tested.
Mutagenicity test: carry out Salmonella reversion test, mice bone marrow micronucleus, mouse inbred strain; Little Polychromatic erythrocyte micronucleus test; Mouse inbred strain.
10 days feeding trials: get SD rat 80, male and female half and half, if 3 Dose Groups Study.
Function animality is tested: SPF level Male Kunming strain mice 160.
6) dosage choice and sample treatment adopt mice burden swimming test, comprise serum urea mensuration, anthrone method liver glycogen measures, blood lactase acid measures.
7) drug-testing experiment:
Product provided by the invention detects through institute of sports medicine drug-testing center of General Administration of Sport, does not find the stimulant of World Anti-Doping Agency's regulation forbidding in 2007, narcotic analgesics, steroidal, diuretic, beta blocker, β 2-agonist, functional drug and glucocorticoid.
Detailed description of the invention
component Source:
Radix Et Caulis Acanthopanacis Senticosi extract: purchased from Jilin Hongjiu Biotech Co., Ltd..
Radix Panacis Quinquefolii extract: purchased from Jilin Hongjiu Biotech Co., Ltd..
Column layer chromatography silicone rubber: purchased from Qingdao Marine Chemical Co., Ltd..
embodiment 1:
A preparation method for the Chinese medicine formula of the kidney invigorating and essence nourishing, brain-strengthening, resisting fatigue, comprises the following steps:
1) 112kg is taken after Cistanche Tubulosa extract being crossed 80 mesh sieves; The leaching process of Cistanche Tubulosa extract is: the Cistanche Tubulosa stem powder methanol eddy of every 5kg drying extracts twice, each 3 hours, be decompressed to vacuum 0.07MPa to concentrate, after solvent evaporated, obtain Cistanche Tubulosa-methanolic extract 1340 g, get wherein 160 g and carry out silica gel column chromatography, with chloroform-methanol-water gradient elution, through thin layer chromatography inspection, merge into 6 eluted fraction Fr.1 ~ Fr.6, after microwave vacuum drying, pulverize, in microwave-vacuum drying, vacuum is 0.07MPa, and baking temperature is 60 DEG C, and drying time is 6 hours;
2) 105kg is taken after Radix Et Caulis Acanthopanacis Senticosi extract being crossed 80 mesh sieves;
3) 50kg is taken after Radix Panacis Quinquefolii extract being crossed 80 mesh sieves;
4) 160kg is taken after microcrystalline Cellulose being crossed 80 mesh sieves;
5) step 1)-step 4) is obtained sieve after the Cistanche Tubulosa extract of proportional quantity, Radix Et Caulis Acanthopanacis Senticosi extract, Radix Panacis Quinquefolii extract and microcrystalline Cellulose mix homogeneously, obtain mixed powder and be finished product.
embodiment 2:
A preparation method for the Chinese medicine formula of the kidney invigorating and essence nourishing, brain-strengthening, resisting fatigue, comprises the following steps:
1) 130kg is taken after Cistanche Tubulosa extract being crossed 80 mesh sieves; The leaching process of Cistanche Tubulosa extract is: the Cistanche Tubulosa stem powder methanol eddy of every 5kg drying extracts twice, each 3 hours, be decompressed to vacuum 0.08MPa to concentrate, after solvent evaporated, obtain Cistanche Tubulosa-methanolic extract 1340 g, get wherein 160 g and carry out silica gel column chromatography, with chloroform-methanol-water gradient elution, through thin layer chromatography inspection, merge into 6 eluted fraction Fr.1 ~ Fr.6, after microwave vacuum drying, pulverize, in microwave-vacuum drying, vacuum is 0.08MPa, and baking temperature is 60 DEG C, and drying time is 8 hours;
2) 120 kg are taken after Radix Et Caulis Acanthopanacis Senticosi extract being crossed 80 mesh sieves;
3) 72 kg are taken after Radix Panacis Quinquefolii extract being crossed 80 mesh sieves;
4) 190 kg are taken after microcrystalline Cellulose being crossed 80 mesh sieves;
5) step 1)-step 4) is obtained sieve after the Cistanche Tubulosa extract of proportional quantity, Radix Et Caulis Acanthopanacis Senticosi extract, Radix Panacis Quinquefolii extract and microcrystalline Cellulose mix homogeneously, obtain mixed powder and be finished product.
embodiment 3:
A preparation method for the Chinese medicine formula of the kidney invigorating and essence nourishing, brain-strengthening, resisting fatigue, comprises the following steps:
1) 121kg is taken after Cistanche Tubulosa extract being crossed 80 mesh sieves, the leaching process of Cistanche Tubulosa extract is: the Cistanche Tubulosa stem powder methanol eddy of every 5kg drying extracts twice, each 3 hours, be decompressed to vacuum 0.075MPa to concentrate, after solvent evaporated, obtain Cistanche Tubulosa-methanolic extract 1340 g, get wherein 160 g and carry out silica gel column chromatography, with chloroform-methanol-water gradient elution, through thin layer chromatography inspection, merge into 6 eluted fraction Fr.1 ~ Fr.6, after microwave vacuum drying, pulverize, in microwave-vacuum drying, vacuum is 0.075MPa, baking temperature is 60 DEG C, drying time is 7 hours,
2) 112 kg are taken after Radix Et Caulis Acanthopanacis Senticosi extract being crossed 80 mesh sieves;
3) 61kg is taken after Radix Panacis Quinquefolii extract being crossed 80 mesh sieves;
4) 175 kg are taken after microcrystalline Cellulose being crossed 80 mesh sieves;
5) step 1)-step 4) is obtained sieve after the Cistanche Tubulosa extract of proportional quantity, Radix Et Caulis Acanthopanacis Senticosi extract, Radix Panacis Quinquefolii extract and microcrystalline Cellulose mix homogeneously, obtain mixed powder and be finished product.
Be below key technology of the present invention point:
1, with pure Chinese medicinal plant extracts such as Cistanche Tubulosas for main formula raw material;
2, Chinese medicinal plant extractive technique innovation:
According to production technology system and the industry standard of Herba Cistanches main active substances phenethyl alcohol glycosides extract, the extractive technique to Herba Cistanches advanced person of Introduced from Japan advanced person and material, the extracting method of design Herba Cistanches active component, the extraction of super cumulative, membrance separation and high-speed countercurrent chromatography, reverse phase silica gel (ODS) separation equipment is adopted to carry out enrichment, echinacoside content in extracted Herba Cistanches extract is made to bring up to 27% by 12.5%, Determination of Acteoside brings up to 8% by 1%, total glycosides >=80%;
3, setting up high-quality herbaceous material can traceability system, realizes production system innovation:
In product provided by the invention, major ingredient Cistanche Tubulosa is all from own standardization plantation farm, specifically set up the basic condition of traceability system, traceability system can realize all batch products from raw material to finished product, from finished product to raw material 100% two-way tracing function.The maximum featured function of this system is exactly the safety of data, and the link of each artificial input is all backed up in realtime by software.
Last it is noted that the foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (4)
1. the Chinese medicine formula of a kidney invigorating and essence nourishing, brain-strengthening, resisting fatigue, it is characterized in that, it is prepared by the following material according to parts by weight: Cistanche Tubulosa extract 112 ~ 130 parts, Radix Et Caulis Acanthopanacis Senticosi extract 105 ~ 120 parts, Radix Panacis Quinquefolii extract 50 ~ 72 parts, microcrystalline Cellulose 160 ~ 190 parts.
2. a kind of the kidney invigorating and essence nourishing according to claim 1, brain-strengthening, the Chinese medicine formula of resisting fatigue, it is characterized in that, the leaching process of described Cistanche Tubulosa extract is: extracted twice by the Cistanche Tubulosa stem powder methanol eddy of 5.0kg drying, each 3 hours, be decompressed to vacuum 0.07 ~ 0.08MPa to concentrate, after solvent evaporated, obtain Cistanche Tubulosa-methanolic extract 1340 g, get wherein 160 g and carry out silica gel column chromatography, with chloroform-methanol-water gradient elution, through thin layer chromatography inspection, merge into 6 eluted fraction Fr.1 ~ Fr.6, after microwave vacuum drying, pulverize, in microwave-vacuum drying, vacuum is 0.07 ~ 0.08MPa, baking temperature is 60 DEG C, drying time is 6 ~ 8 hours.
3. the preparation method of the Chinese medicine formula of a kind of the kidney invigorating and essence nourishing according to claim 1, brain-strengthening, resisting fatigue, is characterized in that, comprise the following steps:
1) proportional quantity is taken after Cistanche Tubulosa extract being crossed 80 mesh sieves;
2) proportional quantity is taken after Radix Et Caulis Acanthopanacis Senticosi extract being crossed 80 mesh sieves;
3) proportional quantity is taken after Radix Panacis Quinquefolii extract being crossed 80 mesh sieves;
4) proportional quantity is taken after microcrystalline Cellulose being crossed 80 mesh sieves;
5) step 1)-step 4) is obtained sieve after the Cistanche Tubulosa extract of proportional quantity, Radix Et Caulis Acanthopanacis Senticosi extract, Radix Panacis Quinquefolii extract and microcrystalline Cellulose mix homogeneously, obtain mixed powder and be finished product.
4. a kind of the kidney invigorating and essence nourishing according to claim 3, brain-strengthening, the preparation method of the health product of the Chinese medicine formula of resisting fatigue, it is characterized in that, the leaching process of the Cistanche Tubulosa extract in described step 1) is: extracted twice by the Cistanche Tubulosa stem powder methanol eddy of 5.0kg drying, each 3 hours, be decompressed to vacuum 0.07 ~ 0.08MPa to concentrate, after solvent evaporated, obtain Cistanche Tubulosa-methanolic extract 1340 g, get wherein 160 g and carry out silica gel column chromatography, with chloroform-methanol-water gradient elution, through thin layer chromatography inspection, merge into 6 eluted fraction Fr.1 ~ Fr.6, after microwave vacuum drying, pulverize, in microwave-vacuum drying, vacuum is 0.07 ~ 0.08MPa, baking temperature is 60 DEG C, drying time is 6 ~ 8 hours.
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| CN108853204A (en) * | 2018-09-21 | 2018-11-23 | 内蒙古蒙肽生物工程有限公司 | A kind of strengthen immunity alleviates the antifatigue traditional Chinese medicine oral liquid of physical strength and preparation method thereof |
| CN112137104A (en) * | 2020-09-18 | 2020-12-29 | 江苏康缘药业股份有限公司 | A kind of composition with function of relieving physical fatigue and preparation method thereof |
| CN121337912A (en) * | 2025-11-25 | 2026-01-16 | 河南中医药大学 | A traditional Chinese medicine composition and its application in the preparation of anti-fatigue health wine |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107095909A (en) * | 2017-03-28 | 2017-08-29 | 新疆旺源生物科技集团有限公司 | The saline cistanche for significantly alleviating physical fatigue effect extracts composition and preparation method thereof |
| CN108853204A (en) * | 2018-09-21 | 2018-11-23 | 内蒙古蒙肽生物工程有限公司 | A kind of strengthen immunity alleviates the antifatigue traditional Chinese medicine oral liquid of physical strength and preparation method thereof |
| CN112137104A (en) * | 2020-09-18 | 2020-12-29 | 江苏康缘药业股份有限公司 | A kind of composition with function of relieving physical fatigue and preparation method thereof |
| WO2022057498A1 (en) * | 2020-09-18 | 2022-03-24 | 江苏康缘药业股份有限公司 | Composition with function of relieving physical fatigue and preparation method therefor |
| CN121337912A (en) * | 2025-11-25 | 2026-01-16 | 河南中医药大学 | A traditional Chinese medicine composition and its application in the preparation of anti-fatigue health wine |
| CN121337912B (en) * | 2025-11-25 | 2026-04-07 | 河南中医药大学 | A traditional Chinese medicine composition and its application in the preparation of anti-fatigue health wine |
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