CN109498661A - A kind of compound probiotics enteric-coated micro-pill and preparation method thereof - Google Patents
A kind of compound probiotics enteric-coated micro-pill and preparation method thereof Download PDFInfo
- Publication number
- CN109498661A CN109498661A CN201811460684.8A CN201811460684A CN109498661A CN 109498661 A CN109498661 A CN 109498661A CN 201811460684 A CN201811460684 A CN 201811460684A CN 109498661 A CN109498661 A CN 109498661A
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- CN
- China
- Prior art keywords
- enteric
- pill
- parts
- coated micro
- probiotics
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/745—Bifidobacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Mycology (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of compound probiotics enteric-coated micro-pills and preparation method thereof, are mainly used in medicine, health food and feed additive field.It is to be mixed and made into pellet of the diameter between 0.8mm-2mm by excipient using various lactobacillus as main component.The activity of lactic acid bacteria can be effectively ensured in the present invention, and for the supplement of intestinal flora, corrective action is obvious, and safety is without side-effects.It is obvious to the improvement result of inferior health.
Description
Technical field
The invention belongs to probiotics site-specific delivery of drugs technology, preparation belongs to pellet, has dissolution fast, is uniformly dispersed, is conducive to
The advantages of probiotics survives.
Background technique
Probiotics acted in enteron aisle it is extremely important, at present probiotics as drug, health food be with powder, capsule,
The forms such as tablet exist, and by gastric acid after taking, cause the probiotics quantity for reaching enteron aisle sharply to reduce, make under product function
Drop.In addition most of probiotic products are using single lactobacillus acidophilus as main component, and with starch, glucose is excipient, bacterium
Class is single, does not act synergistically, and definite value survival rate is relatively low in probiotics environment existing for no prebiotics at the same time, most
Cause effect unobvious eventually.The present invention uses compound probiotics, in conjunction with prebiotics and uses pellet enteric coating technology, directly will
Probiotics is sent to enteron aisle, and then pellet disintegration brings back to life probiotics.The presence of prebiotics increases probiotics largely in a short time
It grows, significant effect.
Summary of the invention
It is an object of that present invention to provide a kind of compound probiotics enteric-coated micro-pills and preparation method thereof.
A kind of compound probiotics enteric-coated micro-pill and preparation method thereof is characterized in micro- made of the raw material by its weight proportion
Ball: 2-4 parts of lactobacillus acidophilus, 35-60 parts of Lactobacillus rhamnosus, 1-2 parts of bifidobacterium bifidum, 35-60 parts of bifidobacterium lactis, blueness
Lactobacillus 35-6- parts of spring, 150-200 parts of xylo-oligosaccharide.
Best weight ratio of the invention is:
2 parts of lactobacillus acidophilus, 35 parts of Lactobacillus rhamnosus, 1 part of bifidobacterium bifidum, 35 parts of bifidobacterium lactis, adolescentis
35 parts, 150 parts of xylo-oligosaccharide.
According to a kind of compound probiotics enteric-coated micro-pill it is characterized in that being made as follows:
A, mentioned component is uniformly mixed according to the ratio spare；
B, take microcrystalline cellulose that water is used to prepare capsule core as adhesive in coating pan, when capsule core diameter reaches 0.3-0.4mm
When, it is dry；
C, capsule core obtained by step B is put into coating pan, uses water as adhesive, is slowly added to A, lamination pill.When pellet diameter
Taking-up when reaching 1-1.2mm, low temperature drying obtain vegetable pill；
D, vegetable pill obtained by step C is coated using No. I Acrylic Resin Emulsion liquid, low temperature drying obtains finished product.
Specific embodiment
Embodiment 1
Take 2 parts of lactobacillus acidophilus, 35 parts of Lactobacillus rhamnosus, 1 part of bifidobacterium bifidum, 35 parts of bifidobacterium lactis, youth cream bar
35 parts of bacterium, 150 parts of xylo-oligosaccharide；
A, mentioned component is uniformly mixed according to the ratio spare；
B, take microcrystalline cellulose that water is used to prepare capsule core as adhesive in coating pan, when capsule core diameter reaches 0.3-0.4mm
When, it is dry；
C, capsule core obtained by step B is put into coating pan, uses water as adhesive, is slowly added to A, lamination pill.When pellet diameter
Taking-up when reaching 1-1.2mm, low temperature drying obtain vegetable pill；
D, vegetable pill obtained by step C is coated using No. I Acrylic Resin Emulsion liquid, low temperature drying obtains finished product.
Claims (5)
1. a kind of compound probiotics enteric-coated micro-pill, it is characterised in that it is lactic acid bacteria, prebiotics, enteric-coating material composition.
2. a kind of compound probiotics enteric-coated micro-pill, it is characterised in that lactic acid bacteria includes lactobacillus acidophilus, Lactobacillus rhamnosus, not tally
Bifidobacterium, bifidobacterium lactis, adolescentis.
3. a kind of compound probiotics enteric-coated micro-pill, it is characterised in that prebiotics are xylo-oligosaccharide.
4. a kind of compound probiotics enteric-coated micro-pill, it is characterised in that enteric coating ingredient is No. I Acrylic Resin Emulsion liquid.
5. a kind of compound probiotics enteric-coated micro-pill, it is characterised in that it is pellet made of the raw material of following weight parts proportion: thermophilic
It is 2 parts of Lactobacillus lactis, 35 parts of Lactobacillus rhamnosus, 1 part of bifidobacterium bifidum, 35 parts of bifidobacterium lactis, 35 parts of adolescentis, low
150 parts of xylan.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811460684.8A CN109498661A (en) | 2018-12-03 | 2018-12-03 | A kind of compound probiotics enteric-coated micro-pill and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811460684.8A CN109498661A (en) | 2018-12-03 | 2018-12-03 | A kind of compound probiotics enteric-coated micro-pill and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109498661A true CN109498661A (en) | 2019-03-22 |
Family
ID=65749875
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811460684.8A Pending CN109498661A (en) | 2018-12-03 | 2018-12-03 | A kind of compound probiotics enteric-coated micro-pill and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109498661A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117159488A (en) * | 2023-09-11 | 2023-12-05 | 维卓(嘉兴)营养品有限公司 | Acid-resistant and bile-salt-resistant probiotic preparation |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101757042A (en) * | 2009-05-25 | 2010-06-30 | 北京诚创康韵医药科技有限公司 | Probiotic pellet preparation and preparing method thereof |
| CN106727725A (en) * | 2016-12-13 | 2017-05-31 | 合肥赛为智慧医疗有限公司 | A kind of probiotics capsulae enterosolubilis and its utricule for treating enteric flora disturbance |
| CN107594284A (en) * | 2017-10-23 | 2018-01-19 | 南京邦康生物技术有限公司 | A kind of solid beverage containing prebiotics and probiotics and preparation method thereof |
| CN108142928A (en) * | 2017-12-25 | 2018-06-12 | 北京数果科技有限公司 | For the compound probiotic composition of intestinal canal regulating and its application |
-
2018
- 2018-12-03 CN CN201811460684.8A patent/CN109498661A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101757042A (en) * | 2009-05-25 | 2010-06-30 | 北京诚创康韵医药科技有限公司 | Probiotic pellet preparation and preparing method thereof |
| CN106727725A (en) * | 2016-12-13 | 2017-05-31 | 合肥赛为智慧医疗有限公司 | A kind of probiotics capsulae enterosolubilis and its utricule for treating enteric flora disturbance |
| CN107594284A (en) * | 2017-10-23 | 2018-01-19 | 南京邦康生物技术有限公司 | A kind of solid beverage containing prebiotics and probiotics and preparation method thereof |
| CN108142928A (en) * | 2017-12-25 | 2018-06-12 | 北京数果科技有限公司 | For the compound probiotic composition of intestinal canal regulating and its application |
Non-Patent Citations (2)
| Title |
|---|
| 朱艳杰等: "乳酸菌制剂的研究与应用前景", 《生物产业技术》 * |
| 朱韶娟: "复合乳酸菌粉调节肠道菌群作用的研究", 《现代食品科技》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117159488A (en) * | 2023-09-11 | 2023-12-05 | 维卓(嘉兴)营养品有限公司 | Acid-resistant and bile-salt-resistant probiotic preparation |
| CN117159488B (en) * | 2023-09-11 | 2024-04-16 | 维卓(嘉兴)营养品有限公司 | Acid-resistant and bile-salt-resistant probiotic preparation |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20190322 |