CN109476759B - Prl3抗体 - Google Patents

Prl3抗体 Download PDF

Info

Publication number
CN109476759B
CN109476759B CN201780037479.8A CN201780037479A CN109476759B CN 109476759 B CN109476759 B CN 109476759B CN 201780037479 A CN201780037479 A CN 201780037479A CN 109476759 B CN109476759 B CN 109476759B
Authority
CN
China
Prior art keywords
prl3
prl
cancer
seq
antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201780037479.8A
Other languages
English (en)
Chinese (zh)
Other versions
CN109476759A (zh
Inventor
曾琦
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Agency for Science Technology and Research Singapore
Original Assignee
Agency for Science Technology and Research Singapore
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agency for Science Technology and Research Singapore filed Critical Agency for Science Technology and Research Singapore
Publication of CN109476759A publication Critical patent/CN109476759A/zh
Application granted granted Critical
Publication of CN109476759B publication Critical patent/CN109476759B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3046—Stomach, Intestines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57446—Specifically defined cancers of stomach or intestine
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201780037479.8A 2016-06-14 2017-06-14 Prl3抗体 Active CN109476759B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SG10201604834P 2016-06-14
SG10201604834P 2016-06-14
PCT/SG2017/050300 WO2017217934A1 (en) 2016-06-14 2017-06-14 Prl3 antibody

Publications (2)

Publication Number Publication Date
CN109476759A CN109476759A (zh) 2019-03-15
CN109476759B true CN109476759B (zh) 2022-11-08

Family

ID=60663634

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780037479.8A Active CN109476759B (zh) 2016-06-14 2017-06-14 Prl3抗体

Country Status (10)

Country Link
US (1) US11155636B2 (enExample)
EP (1) EP3469003A4 (enExample)
JP (2) JP2019531254A (enExample)
KR (1) KR102451588B1 (enExample)
CN (1) CN109476759B (enExample)
AU (1) AU2017285995B2 (enExample)
BR (1) BR112018075901A2 (enExample)
CA (1) CA3025756A1 (enExample)
SG (1) SG11201811068YA (enExample)
WO (1) WO2017217934A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023219091A1 (ja) 2022-05-11 2023-11-16 国立研究開発法人産業技術総合研究所 アンモニア分離膜及びそれを用いたアンモニア分離方法
WO2025116819A1 (en) * 2023-11-30 2025-06-05 Agency For Science, Technology And Research Methods of treating neovascular eye diseases

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050287644A1 (en) * 2004-05-14 2005-12-29 Genesis Biotech Inc. Methods for producing and culturing rabbit-mouse hybridomas and monoclonal antibodies secreted by rabbit-mouse hybridomas
WO2006091326A1 (en) * 2005-01-28 2006-08-31 Attogen Inc. Anti-prl-3 antibodies and methods of use thereof
CN101820910A (zh) * 2007-05-03 2010-09-01 新加坡科技研究局 结合细胞内prl-1多肽或prl-3多肽的抗体
WO2011065923A1 (en) * 2009-11-30 2011-06-03 Agency For Science, Technology And Research Treatment and prevention of cancers associated with intracellular oncoproteins by antibody therapy or vaccination
WO2015119570A1 (en) * 2014-02-07 2015-08-13 Agency For Science, Technology And Research Prl-3 as a biomarker for the prognosis of cancer and a target for therapy

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7462697B2 (en) * 2004-11-08 2008-12-09 Epitomics, Inc. Methods for antibody engineering
JP2012505654A (ja) * 2008-10-14 2012-03-08 ヤンセン バイオテツク，インコーポレーテツド 抗体をヒト化及び親和性成熟する方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050287644A1 (en) * 2004-05-14 2005-12-29 Genesis Biotech Inc. Methods for producing and culturing rabbit-mouse hybridomas and monoclonal antibodies secreted by rabbit-mouse hybridomas
WO2006091326A1 (en) * 2005-01-28 2006-08-31 Attogen Inc. Anti-prl-3 antibodies and methods of use thereof
CN101820910A (zh) * 2007-05-03 2010-09-01 新加坡科技研究局 结合细胞内prl-1多肽或prl-3多肽的抗体
WO2011065923A1 (en) * 2009-11-30 2011-06-03 Agency For Science, Technology And Research Treatment and prevention of cancers associated with intracellular oncoproteins by antibody therapy or vaccination
WO2015119570A1 (en) * 2014-02-07 2015-08-13 Agency For Science, Technology And Research Prl-3 as a biomarker for the prognosis of cancer and a target for therapy

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
《Engineering the first chimeric antibody in targeting intracellular PRL-3 oncoprotein for cancer therapy in mice》;Ke Guo等;《Oncotarget》;20120227;第3卷(第2期);第158-171页 *
《Generation of PRL-3- and PRL-1-specific monoclonal antibodies as potential diagnostic markers for cancer metastases》;Jie Li等;《Clinical Cancer Research》;20050315;第11卷(第6期);第2195-2204页 *
《Monoclonal antibodies target intracellular PRL phosphatases to inhibit cancer metastases in mice》;Ke Guo等;《Cancer Biology & Therapy》;20080520;第7卷(第5期);第750-757页 *

Also Published As

Publication number Publication date
EP3469003A1 (en) 2019-04-17
US20200181283A1 (en) 2020-06-11
AU2017285995A1 (en) 2019-01-31
JP2022078202A (ja) 2022-05-24
KR20190024961A (ko) 2019-03-08
BR112018075901A2 (pt) 2019-03-19
JP2019531254A (ja) 2019-10-31
JP7408707B2 (ja) 2024-01-05
WO2017217934A1 (en) 2017-12-21
SG11201811068YA (en) 2019-01-30
CA3025756A1 (en) 2017-12-21
EP3469003A4 (en) 2020-07-29
AU2017285995B2 (en) 2023-11-30
CN109476759A (zh) 2019-03-15
US11155636B2 (en) 2021-10-26
KR102451588B1 (ko) 2022-10-06

Similar Documents

Publication Publication Date Title
CA3027417C (en) Anti-human trop-2 antibody having an antitumor activity in vivo
JP7443298B2 (ja) ヒト成長分化因子１５（ｇｄｆ－１５）の阻害剤及び免疫チェックポイントブロッカーを使用する併用療法
CN102971337B (zh) 卷曲蛋白结合药剂及其应用
KR102610592B1 (ko) 당화 pd-l1에 특이적인 항체 및 그의 사용 방법
CN103002911B (zh) 卷曲蛋白结合药剂及其应用
AU2011255870B2 (en) Anti-human TROP-2 antibody having antitumor activity in vivo
CA2960466C (en) Cancer cell-specific antibody, anticancer drug and cancer testing method
JP7408707B2 (ja) Ｐｒｌ３抗体
HK40006061A (en) Prl3 antibody
HK40006061B (en) Prl3 antibody
TW202342528A (zh) 抗人類ｃｘｃｌ１抗體
NZ623464B2 (en) Anti-human trop-2 antibody having an antitumor activity in vivo
NZ716839B2 (en) Anti-human trop-2 antibody having an antitumor activity in vivo
NZ716839A (en) Anti-human trop-2 antibody having an antitumor activity in vivo

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40006061

Country of ref document: HK

GR01 Patent grant
GR01 Patent grant