CN109475617B - 抗lag-3抗体及其应用 - Google Patents

抗lag-3抗体及其应用 Download PDF

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Publication number
CN109475617B
CN109475617B CN201880000932.2A CN201880000932A CN109475617B CN 109475617 B CN109475617 B CN 109475617B CN 201880000932 A CN201880000932 A CN 201880000932A CN 109475617 B CN109475617 B CN 109475617B
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antibody
amino acid
cancer
lag
seq
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CN109475617A (zh
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方磊
王正毅
郭炳诗
臧敬五
蒋雯卿
王永强
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Tianjing Biotechnology Hangzhou Co ltd
Tianjing Biotechnology Hong Kong Ltd
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Tianjing Biology
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3

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CN201880000932.2A 2017-02-22 2018-02-22 抗lag-3抗体及其应用 Active CN109475617B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CNPCT/CN2017/074365 2017-02-22
PCT/CN2017/074365 WO2018152687A1 (en) 2017-02-22 2017-02-22 Anti-lymphocyte activation gene-3 (lag-3) antibodies and uses thereof
CN2017088570 2017-06-16
CNPCT/CN2017/088570 2017-06-16
PCT/CN2018/076940 WO2018153340A1 (en) 2017-02-22 2018-02-22 Anti-lag-3 antibodies and uses thereof

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CN109475617A CN109475617A (zh) 2019-03-15
CN109475617B true CN109475617B (zh) 2022-05-17

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EP (1) EP3389702A4 (enExample)
JP (1) JP6929951B2 (enExample)
KR (2) KR102236259B1 (enExample)
CN (1) CN109475617B (enExample)
AU (1) AU2018226298B2 (enExample)
CA (1) CA3053989C (enExample)
IL (1) IL268734A (enExample)
NZ (1) NZ756678A (enExample)
SG (1) SG11201907561PA (enExample)
WO (1) WO2018153340A1 (enExample)
ZA (1) ZA201905790B (enExample)

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EP3833693A4 (en) * 2018-08-21 2023-06-07 ABL Bio Inc. Anti-pd-l1/anti-lag3 bispecific antibodies and uses thereof
CN110678484B (zh) * 2018-08-21 2022-12-27 天境生物科技(杭州)有限公司 抗pd-l1/抗lag3双特异性抗体及其用途
CN110066334B (zh) * 2019-03-22 2020-03-10 南京医科大学 抗Galectin-3的全人源化单域抗体及应用
CN112010975B (zh) * 2019-05-29 2022-09-13 山东博安生物技术股份有限公司 Lag3结合片段及其用途
CN110320367A (zh) * 2019-05-30 2019-10-11 广州医科大学附属第一医院（广州呼吸中心） 基于lag-3的诊断试剂盒及其在帕金森病诊断产品上的应用
CN113966346A (zh) * 2019-06-14 2022-01-21 Abl生物公司 抗a-syn/igf1r的双特异性抗体及其用途
EP3998286A4 (en) * 2019-07-11 2023-04-26 Wuhan Yzy Biopharma Co., Ltd. Tetravalent symmetric bispecific antibody
EP4039711A4 (en) * 2019-07-23 2023-11-15 Nanjing GenScript Biotech Co., Ltd. BISPECIFIC ANTI-CD47/ANTI-LAG-3 ANTIBODY, PREPARATION METHOD AND USE THEREOF
CN113004407B (zh) * 2019-12-20 2022-11-11 广东菲鹏制药股份有限公司 Lag3抗体及其应用
WO2021136392A1 (zh) * 2019-12-30 2021-07-08 上海海路生物技术有限公司 Lag-3抗体及其医药用途
WO2021163989A1 (en) * 2020-02-21 2021-08-26 Yinnuolai Biotech Ltd. Anti-baff receptor antibodies and uses thereof
CN116023484A (zh) * 2020-05-19 2023-04-28 益科思特(北京)医药科技发展有限公司 抗新型冠状病毒Spike蛋白抗体及其应用
CN111808192B (zh) * 2020-06-05 2022-02-15 北京天广实生物技术股份有限公司 结合lag3的抗体及其用途
CN112062832B (zh) * 2020-09-24 2021-08-03 河南赛诺特生物技术有限公司 Galectin-3抗原表位肽、抗原、抗体、杂交瘤细胞株及试剂盒
CN114621345B (zh) * 2020-12-10 2022-11-29 北京东方百泰生物科技股份有限公司 一种抗lag-3的单克隆抗体、其抗原结合片段及其应用
MX2023009100A (es) 2021-02-03 2023-09-25 Mozart Therapeutics Inc Agentes aglutinantes y métodos para usar los mismos.
CN115490764B (zh) * 2021-06-18 2025-06-03 佛山热休生物技术有限公司 Lgals3的表位肽及所述表位肽与热休克蛋白的复合物
WO2023076876A1 (en) 2021-10-26 2023-05-04 Mozart Therapeutics, Inc. Modulation of immune responses to viral vectors
US20250198990A1 (en) * 2022-03-15 2025-06-19 The Board Of Trustees Of The Leland Stanford Junior University Methods of Identifying Anti-LAG-3 Agents
CN115819595B (zh) * 2023-01-03 2023-05-16 上海百英生物科技股份有限公司 一种抗lag3纳米抗体及其制备方法与应用
WO2024189628A1 (en) * 2023-03-16 2024-09-19 Technion Research And Development Foundation Limited Lag-3 inhibition for enhanced antiviral immune response
WO2024196072A1 (ko) * 2023-03-20 2024-09-26 경북대학교 산학협력단 Lag-3에 결합하는 펩타이드 및 이의 용도
TW202509063A (zh) * 2023-08-21 2025-03-01 瑞士商百濟神州瑞士有限責任公司 用抗lag3、抗pd-1和化學療法治療食管癌
WO2025128836A1 (en) * 2023-12-13 2025-06-19 Eli Lilly And Company Lag-3 agonist antibodies

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CA3053989C (en) 2024-10-29
KR102236259B1 (ko) 2021-04-06
KR20190111894A (ko) 2019-10-02
KR102144317B1 (ko) 2020-08-18
EP3389702A1 (en) 2018-10-24
US20200071403A1 (en) 2020-03-05
US20190225687A1 (en) 2019-07-25
CA3053989A1 (en) 2018-08-30
KR20180113195A (ko) 2018-10-15
SG11201907561PA (en) 2019-09-27
CN109475617A (zh) 2019-03-15
US11414485B2 (en) 2022-08-16
ZA201905790B (en) 2025-03-26
US10577421B2 (en) 2020-03-03
WO2018153340A1 (en) 2018-08-30
EP3389702A4 (en) 2019-08-14
AU2018226298B2 (en) 2022-02-17
JP2020508303A (ja) 2020-03-19
NZ756678A (en) 2023-02-24
JP6929951B2 (ja) 2021-09-01
IL268734A (en) 2019-10-31

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Applicant before: Tianjing biotechnology Hong Kong Ltd.

GR01 Patent grant
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PE01 Entry into force of the registration of the contract for pledge of patent right
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Denomination of invention: Anti-LAG-3 antibody and its application

Granted publication date: 20220517

Pledgee: Zheshang Bank Co.,Ltd. Hangzhou Branch

Pledgor: Tianjing Biotechnology (Hangzhou) Co.,Ltd.

Registration number: Y2025330000258