CN109468360B - Tension-compression integrated loading device for spinal motion segment - Google Patents
Tension-compression integrated loading device for spinal motion segment Download PDFInfo
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- CN109468360B CN109468360B CN201710807406.4A CN201710807406A CN109468360B CN 109468360 B CN109468360 B CN 109468360B CN 201710807406 A CN201710807406 A CN 201710807406A CN 109468360 B CN109468360 B CN 109468360B
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- 238000001727 in vivo Methods 0.000 description 3
- 208000021600 intervertebral disc degenerative disease Diseases 0.000 description 3
- 210000000056 organ Anatomy 0.000 description 3
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- 238000006243 chemical reaction Methods 0.000 description 2
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- 239000003814 drug Substances 0.000 description 1
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- 238000011124 ex vivo culture Methods 0.000 description 1
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Abstract
The utility model relates to a spinal motion segment draws and presses integral type loading device includes: a base; the culture dish is placed on the base and used for culturing the spinal motion segment in vitro; the guide shaft extends along the up-down direction, and the lower end of the guide shaft is fixed on the base; the loading platform is positioned above the culture dish and is in sliding fit with the guide shaft, and a first weight is placed on the loading platform; the pulley mechanism comprises a fixed pulley and a steel wire rope, the fixed pulley is positioned above the loading platform, the first end of the steel wire rope is connected with the loading platform, and the second end of the steel wire rope is used for connecting a second weight; the spinal column lower support is arranged in the culture dish, is fixed relative to the culture dish and is used for being connected with the lower end of the spinal column motion segment; and the spinal upper support is at least partially arranged in the culture dish, is fixed on the loading platform and is used for being connected with the upper end of the spinal motion segment.
Description
Technical Field
The disclosure relates to the field of clinical medicine experimental instruments, in particular to a tension-compression integrated loading device for a spinal motion segment.
Background
At present, two main methods are used for researching the intervertebral disc degeneration and mechanical correlation, one is to apply external force intervention to the intervertebral disc in a living body and dynamically observe the influence of mechanics on the intervertebral disc in an in vivo environment; the other type is that external force is applied to intervertebral disc cells or organs cultured in vitro, and the direct influence of the external force on intervertebral disc tissues is researched.
However, the current methods have the following disadvantages:
1. in the first in vivo force application method, since it is difficult to control all biochemical and biomechanical factors in vivo, it is not beneficial to study the influence of specific mechanical factors, such as the influence of intervertebral disc degeneration caused by simple pressure or the influence of intervertebral disc degeneration caused by simple tension;
2. another cell model in an in vitro culture mode is usually carried out in a six-well plate, the influence of mechanics on the model is difficult to observe, the cell proliferation rate is low due to the loss of a special extracellular matrix environment, the phenotype is easy to lose, the vitality and the interaction among various types of cells are difficult to maintain, so the mechanical characteristics of the cell model are difficult to truly reflect the mechanical characteristics of the spine, and the result is often inaccurate;
3. due to the characteristics of the intervertebral disc (the center is provided with elastic gelatinous nucleus pulposus, and the outside is provided with fiber rings which are formed by arranging a plurality of layers of fibrocartilage according to concentric circles), when the intervertebral disc organ model receives force application outside the body, the stress situation of the vertebral column motion segment of the intervertebral disc organ model inside the body is often greatly different from the stress situation of the vertebral column motion segment inside the body, for example, details such as the state of the force application surface and the like often bring great influence on the whole stress situation, so that the stress situation of the vertebral column inside the body is difficult to realize real simulation;
4. research on ex vivo culture of spinal motion segments in relation to static compression and tension is currently open.
Disclosure of Invention
The purpose of the present disclosure is to provide a tension-compression integrated loading device for a spinal motion segment, which can meet two different loading requirements of constant tension loading and constant pressure loading.
In order to achieve the above object, the present disclosure provides a spinal motion segment tension and compression integrated loading device, comprising: a base; the culture dish is placed on the base and used for culturing the spinal motion segment in vitro; the guide shaft extends along the up-down direction, and the lower end of the guide shaft is fixed on the base; the loading platform is positioned above the culture dish and is in sliding fit with the guide shaft, and a first weight is placed on the loading platform; the pulley mechanism comprises a fixed pulley and a steel wire rope, the fixed pulley is positioned above the loading platform, the first end of the steel wire rope is connected with the loading platform, and the second end of the steel wire rope is used for connecting a second weight; the spinal column lower support is arranged in the culture dish, is fixed relative to the culture dish and is used for being connected with the lower end of the spinal column motion segment; and the spinal upper support is at least partially arranged in the culture dish, is fixed on the loading platform and is used for being connected with the upper end of the spinal motion segment.
Optionally, the bottom of the culture dish is provided with a mounting hole, and the spinal column lower support is connected to the base through a fastener penetrating through the mounting hole.
Optionally, the base includes base body and culture dish fixing support, culture dish fixing support's upper surface is provided with the culture dish constant head tank, be formed with mounting flange around culture dish fixing support, mounting flange pass through the fastener connect in base body.
Optionally, the loading device further includes an upper support, an upper end of the guide shaft is fixed to the upper support, and the loading platform is located between the upper support and the base.
Optionally, the guide shafts are two symmetrically arranged about the central axis of the culture dish, and the fixed pulleys are two symmetrically arranged about the central axis of the culture dish.
Optionally, the fixed pulley is mounted on the upper support.
Optionally, the upper support is provided with a first via hole and a second via hole, the first end of the steel wire rope passes through the first via hole to be connected with the loading platform, and the second end of the steel wire rope passes through the second via hole to be connected with the second weight.
Optionally, a through hole for avoiding the first weight is formed in the upper support.
Optionally, a weight positioning groove is formed in the upper surface of the loading table, the spine upper support is fixed to the lower surface of the loading table, and the weight positioning groove corresponds to the spine upper support in position.
Optionally, the spinal column lower support is provided with a first groove for accommodating the lower end of the spinal column motion segment, the side wall of the first groove is provided with a first group of threaded holes, and a jackscrew capable of butting against the spinal column motion segment is arranged in the first group of threaded holes; the upper spinal support is provided with a second groove for accommodating the upper end of the spinal motion segment, the side wall of the second groove is provided with a second group of threaded holes, and a jackscrew capable of butting against the spinal motion segment is arranged in the second groove.
Through above-mentioned technical scheme for can provide a spinal motion segment and draw pressure integral type loading device, the device can turn into the gravity of weight pulling force or pressure of loading on spinal motion segment, can realize the output of constant force, and through the mode of simple change weight quantity, realize the constant force pressurization and the tensile conversion of constant force. The device is simple to operate, can provide constant force loading in the isolated culture process of the spinal motion segment, and can be used for researching the mechanical characteristics of the spinal motion segment under the constant force loading.
Additional features and advantages of the disclosure will be set forth in the detailed description which follows.
Drawings
The accompanying drawings, which are included to provide a further understanding of the disclosure and are incorporated in and constitute a part of this specification, illustrate embodiments of the disclosure and together with the description serve to explain the disclosure, but do not constitute a limitation of the disclosure. In the drawings:
FIG. 1 is a front view of a spinal motion segment tension and compression integrated loading device with culture dishes only shown in part according to one embodiment of the present disclosure;
FIG. 2 is a perspective view of a spinal motion segment tension and compression integrated loading device with culture dishes only shown in part according to one embodiment of the present disclosure;
FIG. 3 is a schematic view of a spinal motion segment tension and compression integrated loading device in a constant tension loading mode with a culture dish only partially shown, according to one embodiment of the present disclosure;
FIG. 4 is a schematic view of a spinal motion segment tension and compression integrated loading device in a constant pressure loading mode with culture dishes only shown in part, according to one embodiment of the present disclosure;
FIG. 5 is a cross-sectional view of a spinal motion segment tension and compression integrated loading device according to one embodiment of the present disclosure;
FIG. 6 is a schematic view of a culture dish in a spinal motion segment tension and compression integrated loading device according to one embodiment of the present disclosure.
Description of the reference numerals
1. First groove of spinal column lower support 110
120. First group of threaded holes 2 spinal column upper support
210. Second recess 220 second set of threaded holes
3. Guide shaft 4 loading platform
41. Weight positioning groove 5 pulley mechanism
51. Fixed pulley 52 steel wire rope
53. 6 spinal motion segments of pulley block
7. First weight 8 second weight
9. Upper support 91 first via hole
92. Second via 93 through hole
10. Base 101 culture dish fixing support
1011. Culture dish constant head tank 1012 mounting flange
102. Base body 11 culture dish
111. First guide shaft fixing seat of mounting hole 12
13. Second guiding axle fixing seat 14 bush
15. Bushing press plate 16 extension tube
17. Fastening screw
Detailed Description
The following detailed description of specific embodiments of the present disclosure is provided in connection with the accompanying drawings. It should be understood that the detailed description and specific examples, while indicating the present disclosure, are given by way of illustration and explanation only, not limitation.
In the present disclosure, unless otherwise stated, the use of directional terms such as "upper and lower" generally refers to the upper and lower positions of the spinal motion segment tension and compression integrated loading device in the normal use state of the spinal motion segment tension and compression integrated loading device, and reference can be made specifically to the drawing direction of the attached drawings.
Referring to fig. 1 to 6, the spinal motion segment tension-compression integrated loading device of the present disclosure includes a base 10, a culture dish 11 (not limited to a standard culture dish, but may be any container with the same structure), a spinal lower support 1, a spinal upper support 2, a guide shaft 3, a loading platform 4, and a pulley mechanism 5.
The spinal motion segment 6 may be a segment of a spine having at least two vertebral bodies including at least upper and lower cartilaginous endplates, an annulus fibrosus, nucleus pulposus tissue, and adjacent vertebral bodies.
The culture dish 11 can be arranged on the base 10, the culture dish 11 has a containing space for placing the spinal motion segment 6 for in vitro culture, and the outer wall of the culture dish 11 can be made of transparent material, such as glass, for observation.
Referring to fig. 6, the top of the culture dish 11 may have an opening for insertion/extraction of the spinal sub-support 1, the spinal upper support 2, and the spinal motion segment 6.
The side wall of the culture dish 11 may be provided with a liquid inlet and outlet, and the liquid inlet and outlet is connected with an extension tube 16 extending to the outside of the culture dish 11 for injecting the culture liquid into the accommodating space or discharging the culture liquid from the accommodating space.
The spinal sub-mount 1 may be relatively fixedly disposed in the culture dish 11 and may be placed directly on the bottom of the culture dish 11. Specifically, referring to fig. 5 and 6, the bottom of the culture dish 11 may be provided with mounting holes 111, and the spinal sub-mount 1 may be connected to the base 10 via fasteners passing through the mounting holes 111.
Referring to fig. 5, the spinal column lower support 1 is connected with the lower end of the spinal column motion segment 6, the spinal column lower support 1 may have a first groove 110, the lower end of the spinal column motion segment 6 is disposed in the first groove 110, the end surface of the lower end of the spinal column motion segment 6 abuts against the bottom surface of the first groove 110, and the bottom surface of the first groove 110 forms a support for the spinal column motion segment 6, so as to vertically fix the spinal column motion segment 6 and facilitate vertical loading of the spinal column motion segment 6 by external force.
Referring to fig. 3, the side walls of the first recess 110 can be provided with a first set of threaded holes 120 in which a jackscrew can be positioned against the spinal motion segment 6 to further stabilize the vertical fixation of the spinal motion segment 6 and further improve the vertical loading of the spinal motion segment 6 by external forces. The first group of threaded holes 120 may be three evenly distributed on the circumference, and each two of the three threaded holes form an included angle of 120 degrees, and the jackscrews in the three threaded holes respectively abut against (can form positioning by abutting slightly) the middle of three side surfaces of the lower vertebral body of the spinal motion segment 6, so as to form stable positioning.
Referring to fig. 5, the spinal upper mount 2 is partially disposed in a culture dish 11 and is connected to the upper end of the spinal motion segment 6. The spinal upper support 2 can have a second recess 210, with the upper end of the spinal motion segment 6 disposed in the second recess 210, and with the end surface of the upper end of the spinal motion segment 6 abutting the bottom surface of the second recess 210. External forces are applied to the spinal motion segment 6 via the spinal upper support 2 to effect vertical fixation of the spinal motion segment 6 and facilitate vertical loading of the spinal motion segment 6 by the external forces.
Referring to fig. 3, the sidewalls of the second recess 210 can be provided with a second set of threaded holes 220 in which a jackscrew can be positioned against the spinal motion segment 6 to further stabilize the vertical fixation of the spinal motion segment 6 and further improve the vertical loading of external forces on the spinal motion segment 6. The second group of threaded holes 220 may also be three evenly distributed on the circumference, an included angle of 120 degrees is formed between every two threaded holes, and screws in the three threaded holes 34 respectively abut against (can be positioned by abutting slightly) the middle of three side surfaces of the upper vertebral body of the spinal motion segment 6, so as to form stable positioning.
The outer side wall of the backbone upper support 2 can be made into a state with the inner side wall of the culture dish 11, and the inner side wall of the culture dish 11 is utilized to realize the guiding of the backbone upper support 2 during the movement.
Referring to fig. 5, the base 10 may include a base body 102 and a culture dish fixing support 101. The upper surface of culture dish fixing support 101 can be equipped with culture dish constant head tank 1011, supplies culture dish 11 location to place. A mounting flange 1012 is provided around the culture dish holder 101, and the mounting flange 1012 may be coupled to the base body 102 by fasteners.
Two guiding axles 3 can set up respectively in the both sides of culture dish constant head tank 1011, and the lower extreme of every guiding axle 3 can be fixed in base 10 through first guiding axle fixing base 12, and the upper end of every guiding axle 3 can be fixed in upper bracket 9 through second guiding axle fixing base 13. The first guide shaft fixing seat 12 is connected to the base 10 by a fastener, and the second guide shaft fixing seat 13 is connected to the upper support 9 by a fastener. Every guiding axle fixing base has the centre bore that supplies guiding axle 3 to pass, and the side of every guiding axle fixing base is equipped with locking screw, can reduce the space between centre bore and the guiding axle 3 through rotatory locking screw to realize the fixed of guiding axle 3. The two guide shafts 3 may be arranged symmetrically about the central axis of the culture dish 11.
The loading table 4 can be arranged between the base 10 and the upper support 9 and can slide up and down along the guide shaft 3, the spine upper support 2 can be fixed at the position where the lower surface of the loading table 4 is just opposite to the culture dish positioning groove 1011 through a fastener, and the weight positioning groove 41 can be arranged at the position where the upper surface of the loading table 4 corresponds to the spine upper support 2. The diameter of the weight positioning slot 41 can be the same as the diameter of the first weight 7, so that vertical loading can be ensured.
Referring to fig. 1, a guide hole may be formed in the loading table 4, a bushing 14 may be disposed in the guide hole, a bushing pressing plate 15 may be coupled to the loading table 4 by a fastener, and the bushing pressing plate 15 may fix the bushing 14 in the guide hole. The guide shaft 3 passes through the bush 14, so that the loading table 4 can slide up and down along the guide shaft 3.
The middle part of the upper support 9 can be provided with a through hole 93, and the center of the through hole 93 is opposite to the center of the weight positioning groove 41 so as to avoid the first weight 7 placed in the weight positioning groove 41.
The pulley mechanism 5 may include a fixed pulley 51, a cable 52 and a pulley seat 53, the fixed pulley 51 is located above the loading platform 4, a first end of the cable 52 may be connected to the loading platform 4 through a fastening screw 17, for example, a second end of the cable 52 may be connected to a second weight 8, and the pulley seat 53 may be mounted on the upper support 9 through a fastening member.
Referring to fig. 5, in order to make the structure more compact, the upper seat 9 may have a first through hole 91 through which one end of the wire rope 52 passes to be connected to the loading table 4, and a second through hole 92 through which the other end of the wire rope 52 passes to be connected to the second weight 8.
The number of the pulley mechanisms 5 may be two or more, and the two or more pulley mechanisms may be symmetrically arranged about the central axis of the culture dish 11 to ensure that the loading platform 4 is uniformly stressed.
The tension-compression integrated loading device can realize constant pressure loading and constant tension loading on the spinal motion segment.
Implementation of constant pressure loading: referring to fig. 4, the first weight 7 is placed in the weight positioning groove 41, the second weights 8 on two sides are hung on the steel wire rope 52, and the weight of the first weight 7 is larger than that of the second weights 8 by increasing the number of the first weights 7. Pressure is exerted on the loading platform 4 through gravity, the loading platform 4 exerts constant pressure on the spinal motion segment 6 through the spinal upper support 2, and creep influence of the spinal motion segment due to long-term stress is avoided, so that constant pressure loading can be realized;
and (3) realizing constant tension loading: referring to fig. 3, similar to constant pressure loading, the first weight 7 is also placed in the weight positioning groove 41, the second weights 8 on two sides are hung on the steel wire rope, the number of the second weights 8 is increased or the number of the first weights 7 is reduced, so that the weight of the second weights 8 exceeds the weight of the first weights 7, the second weights are converted into the tension of the loading table 4 through the steel wire rope 52, the loading table 4 applies constant tension to the spinal motion segment 6 through the spinal upper support 2, and the influence caused by spinal creep is eliminated, so that constant tension loading can be realized.
In conclusion, the present disclosure provides a spinal motion segment tension and compression integrated loading device, which can convert the gravity of a weight into a tension or a compression force loaded on a spinal motion segment, can realize the output of a constant force, and can realize the conversion between constant force pressurization and constant force stretching in a simple manner of changing the number of weights. The device is simple to operate, can provide constant force loading in the in vitro culture process of the spinal motion segment, and can be used for researching the mechanical characteristics of the spinal motion segment under the constant force loading.
The loading device disclosed by the invention can simultaneously meet two different loading requirements of tension loading and pressure loading. In addition, the loading device disclosed by the invention can avoid the creep influence of the spinal motion segment due to long-term stress, and always keeps the loading force constant in the loading process.
The preferred embodiments of the present disclosure are described in detail above with reference to the accompanying drawings, however, the present disclosure is not limited to the specific details in the above embodiments, and various simple modifications may be made to the technical solution of the present disclosure within the technical idea of the present disclosure, and these simple modifications all belong to the protection scope of the present disclosure.
It should be noted that the various features described in the above embodiments may be combined in any suitable manner without departing from the scope of the invention. To avoid unnecessary repetition, the disclosure does not separately describe various possible combinations.
In addition, any combination of various embodiments of the present disclosure may be made, and the same should be considered as the disclosure of the present disclosure, as long as it does not depart from the spirit of the present disclosure.
Claims (7)
1. A spinal motion segment tension and compression integrated loading device, comprising:
the upper surface of the base is provided with a culture dish positioning groove;
an upper support;
the culture dish is placed on the base and used for culturing the spinal motion segment in vitro;
the guide shafts extend along the vertical direction, the lower ends of the guide shafts are fixed on the base, the upper ends of the guide shafts are fixed on the upper support, and the two guide shafts are symmetrically arranged about the central axis of the culture dish;
the loading platform is positioned above the culture dish and is in sliding fit with the guide shaft, a first weight is placed on the loading platform, and the loading platform is positioned between the upper support and the base;
the two pulley mechanisms are respectively and symmetrically arranged on two sides of the culture dish, each pulley mechanism comprises a fixed pulley and a steel wire rope wound on the fixed pulley, the fixed pulleys are arranged on the upper support, the first end of each steel wire rope is connected with the loading platform, and the second end of each steel wire rope is used for connecting a second weight;
the spinal column lower support is arranged in the culture dish, is fixed relative to the culture dish and is used for being connected with the lower end of the spinal column motion segment;
the spinal column upper support is at least partially arranged in the culture dish, fixed at the position, right opposite to the culture dish positioning groove, of the lower surface of the loading platform and used for being connected with the upper end of the spinal column motion section, weight positioning grooves are formed in the upper surface of the loading platform, and the weight positioning grooves correspond to the spinal column upper support in position.
2. The loading device of claim 1, wherein the bottom of the culture dish is provided with a mounting hole, and the under-spine support is connected to the base via a fastener passing through the mounting hole.
3. The loading device of claim 2, wherein the base comprises a base body and a culture dish fixing support, the upper surface of the culture dish fixing support is provided with a culture dish positioning groove, a mounting flange is formed around the culture dish fixing support, and the mounting flange is connected to the base body through a fastener.
4. The loading device of claim 1, wherein the fixed pulleys are two symmetrically arranged about a central axis of the culture dish.
5. The loading device as claimed in claim 1, wherein the upper support has a first through hole and a second through hole, the first end of the steel wire rope passes through the first through hole to connect to the loading platform, and the second end of the steel wire rope passes through the second through hole to connect to the second weight.
6. The loading device according to claim 1, wherein a through hole for avoiding the first weight is formed in the upper support.
7. The loading device according to claim 1, wherein the spinal column lower support has a first groove for receiving the lower end of the spinal column motion segment, the side wall of the first groove is provided with a first group of threaded holes, and a jackscrew capable of butting against the spinal column motion segment is arranged in the first group of threaded holes;
the upper spinal support is provided with a second groove for accommodating the upper end of the spinal motion segment, the side wall of the second groove is provided with a second group of threaded holes, and a jackscrew capable of butting against the spinal motion segment is arranged in the second groove.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710807406.4A CN109468360B (en) | 2017-09-08 | 2017-09-08 | Tension-compression integrated loading device for spinal motion segment |
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| CN201710807406.4A CN109468360B (en) | 2017-09-08 | 2017-09-08 | Tension-compression integrated loading device for spinal motion segment |
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| CN109468360A CN109468360A (en) | 2019-03-15 |
| CN109468360B true CN109468360B (en) | 2022-11-04 |
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| CN112881161A (en) * | 2021-01-19 | 2021-06-01 | 吉林大学 | Biological limb fixing device for tension-compression test |
| CN115369037B (en) * | 2022-10-24 | 2023-01-31 | 中国中医科学院望京医院(中国中医科学院骨伤科研究所) | Full circulation device, method and loading system for spinal culture solution |
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| 一种脊柱运动的加载装置和测量方法;卢海俊等;《中国临床解剖学杂志》;19930425(第02期);第147-148页 * |
| 人体脊柱三维运动测量及力学加载进展;姜永立等;《医用生物力学》;20090815(第04期);第311-316页 * |
| 脊柱离体运动加载方法研究进展;季伟等;《医用生物力学》;20120815(第04期);第464-469页 * |
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