CN109467586B - 一种纽甜的精制方法 - Google Patents
一种纽甜的精制方法 Download PDFInfo
- Publication number
- CN109467586B CN109467586B CN201811537884.9A CN201811537884A CN109467586B CN 109467586 B CN109467586 B CN 109467586B CN 201811537884 A CN201811537884 A CN 201811537884A CN 109467586 B CN109467586 B CN 109467586B
- Authority
- CN
- China
- Prior art keywords
- neotame
- refining
- impurity
- water
- alkali
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
- C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
- C07K5/0613—Aspartame
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (7)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201811537884.9A CN109467586B (zh) | 2018-12-15 | 2018-12-15 | 一种纽甜的精制方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201811537884.9A CN109467586B (zh) | 2018-12-15 | 2018-12-15 | 一种纽甜的精制方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN109467586A CN109467586A (zh) | 2019-03-15 |
CN109467586B true CN109467586B (zh) | 2021-06-22 |
Family
ID=65675396
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201811537884.9A Active CN109467586B (zh) | 2018-12-15 | 2018-12-15 | 一种纽甜的精制方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN109467586B (zh) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110563797A (zh) * | 2019-10-12 | 2019-12-13 | 山东奔月生物科技股份有限公司 | 纽甜中粘性成分的去除方法 |
CN114292310A (zh) * | 2021-12-30 | 2022-04-08 | 山东诚汇双达药业有限公司 | 一种纽甜a晶型的制备方法 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001087927A2 (en) * | 2000-05-18 | 2001-11-22 | The Nutrasweet Company | gYNTHESIS OF N-[N-(3,3-DIMETHYLBUTYL)-L-α-ASPARTYL]-L-PHENYLALANINE 1-METHYL ESTER USING L-α-ASPARTYL-L-PHENYLALANINE 1-METHYL ESTER PRECURSORS |
CN104177473A (zh) * | 2014-08-20 | 2014-12-03 | 山东奔月生物科技有限公司 | 纽甜的合成方法 |
CN105504006A (zh) * | 2016-01-28 | 2016-04-20 | 柳玉荣 | 一种提高纽甜质量的合成方法 |
CN105541965A (zh) * | 2016-01-28 | 2016-05-04 | 柳玉荣 | 一种提高纽甜得率的合成方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6720446B2 (en) * | 2001-11-05 | 2004-04-13 | The Nutrasweet Company | Catalyst modification to enhance neotame production |
-
2018
- 2018-12-15 CN CN201811537884.9A patent/CN109467586B/zh active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001087927A2 (en) * | 2000-05-18 | 2001-11-22 | The Nutrasweet Company | gYNTHESIS OF N-[N-(3,3-DIMETHYLBUTYL)-L-α-ASPARTYL]-L-PHENYLALANINE 1-METHYL ESTER USING L-α-ASPARTYL-L-PHENYLALANINE 1-METHYL ESTER PRECURSORS |
CN104177473A (zh) * | 2014-08-20 | 2014-12-03 | 山东奔月生物科技有限公司 | 纽甜的合成方法 |
CN105504006A (zh) * | 2016-01-28 | 2016-04-20 | 柳玉荣 | 一种提高纽甜质量的合成方法 |
CN105541965A (zh) * | 2016-01-28 | 2016-05-04 | 柳玉荣 | 一种提高纽甜得率的合成方法 |
Non-Patent Citations (1)
Title |
---|
纽甜多晶晶型的制备及其特性的研究进展;曹中;《食品科技》;20070420(第4期);131-133 * |
Also Published As
Publication number | Publication date |
---|---|
CN109467586A (zh) | 2019-03-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN109467586B (zh) | 一种纽甜的精制方法 | |
CN101591366B (zh) | 分离高纯度瑞鲍迪甙a的工艺 | |
CN110872332B (zh) | 一种阿洛酮糖的结晶工艺 | |
KR920000648B1 (ko) | α-L-아스파르틸-L-페닐알라닌 메틸 에스테르의 분리방법 | |
CN109180749B (zh) | 一种利用过饱和结晶法制备高纯度n-乙酰神经氨酸水合物的方法 | |
CN109503680A (zh) | 一种三氯蔗糖-6-乙酯母液酯相处理方法 | |
CN104045688B (zh) | 一种纽甜的合成方法 | |
CN112047999B (zh) | 一种γ晶型的精氨酸培哚普利盐的制备方法 | |
US8252922B2 (en) | Method for crystallizing sucralose | |
CN112552167A (zh) | 葡萄糖酸钙的制备方法 | |
CN105566098A (zh) | 一种高纯度结晶乙酸钙和无水乙酸钙的联产方法 | |
JP2007191413A (ja) | 純粋グルコサミン及びその製造方法 | |
CN1985624A (zh) | 一种塔格糖的生产工艺 | |
CN114031655A (zh) | 一种甜菊糖苷的结晶方法 | |
US4011263A (en) | Process for the production of n-acetyl-l-methionine | |
CN112321676B (zh) | 一种纽甜的成盐方法 | |
JPH0570478A (ja) | α−L−アスパルチル−L−フエニルアラニンメチルエステルの製造方法 | |
CN108676064B (zh) | 一种高效合成纽甜的方法 | |
CN1706792A (zh) | 一种3、4、5——三甲氧基苯甲酸的提纯方法 | |
CN110156592A (zh) | 5(6)-癸烯酸的提纯方法 | |
CN116199601B (zh) | 高含量百菌清的精制提纯工艺 | |
CN113264822B (zh) | 一种富马酸二钠的制备方法 | |
EP2091868B1 (en) | Method of preparing potassium hydroxide dihydrate | |
CN115850057A (zh) | 一水葡萄糖酸钙的制备方法 | |
CN113788749A (zh) | 一种甜味抑制剂2-(4-甲氧基苯基)丙酸钠的工业化制备方法及应用 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20200810 Address after: 250101 Jinan Chenghui Shuangda Chemical Co.,Ltd., No. 2350 Kaifeng Road, High tech Zone, Jinan City, Shandong Province Applicant after: JINAN CHENGHUISHUANGDA CHEMICAL INDUSTRY Co.,Ltd. Applicant after: SHANDONG CHENGHUI SHUANGDA PHARMACEUTICAL CO.,LTD. Address before: 253100 Shandong Dezhou Plain Economic Development Zone North Second Ring Road West First Road North Shandong Chenghui Shuangda Pharmaceutical Co., Ltd. Applicant before: SHANDONG CHENGHUI SHUANGDA PHARMACEUTICAL Co.,Ltd. |
|
TA01 | Transfer of patent application right | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A refining method of neotame Effective date of registration: 20220616 Granted publication date: 20210622 Pledgee: Shandong Pingyuan Rural Commercial Bank Co.,Ltd. Pledgor: SHANDONG CHENGHUI SHUANGDA PHARMACEUTICAL CO.,LTD. Registration number: Y2022980007784 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20230726 Granted publication date: 20210622 Pledgee: Shandong Pingyuan Rural Commercial Bank Co.,Ltd. Pledgor: SHANDONG CHENGHUI SHUANGDA PHARMACEUTICAL CO.,LTD. Registration number: Y2022980007784 |
|
PC01 | Cancellation of the registration of the contract for pledge of patent right |