CN109464605A - It is a kind of to treat the pharmaceutical composition for leading to pain disease by mould - Google Patents
It is a kind of to treat the pharmaceutical composition for leading to pain disease by mould Download PDFInfo
- Publication number
- CN109464605A CN109464605A CN201811607664.9A CN201811607664A CN109464605A CN 109464605 A CN109464605 A CN 109464605A CN 201811607664 A CN201811607664 A CN 201811607664A CN 109464605 A CN109464605 A CN 109464605A
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- rhizoma
- radix
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/237—Notopterygium
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- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/232—Angelica
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Polymers & Plastics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Food Science & Technology (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physiology (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention category medical health field, being related to Chinese tradition classical prescription " Decoction of Notopterygium for Rheumatism " plus-minus is led to the drug of pain disease or the new application of health care product by mycotic infection in preparation treatment, and in particular to the new application of bulk pharmaceutical chemicals Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, rhizoma ligustici, radix saposhnikoviae, Radix Glycyrrhizae, fructus viticis, Rhizoma Chuanxiong, Rhizoma Gastrodiae, rhizoma corydalis, galangal, monkshood, pepper, the chemical component alkaloid contained in piper cubeba and volatile oil in the drug or health care product that preparation causes pain disease because of mycotic infection.
Description
Technical field
The invention category medical health field, be related to Chinese tradition classical prescription " Decoction of Notopterygium for Rheumatism " plus-minus preparation treatment by
Mycotic infection leads to the drug of pain disease or the new application of health care product, and in particular to bulk pharmaceutical chemicals Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, rhizoma ligustici, radix saposhnikoviae,
Radix Glycyrrhizae, fructus viticis, Rhizoma Chuanxiong, Rhizoma Gastrodiae, rhizoma corydalis, galangal, monkshood, pepper, the chemical component alkaloid contained in piper cubeba and
New application of the volatile oil in the drug or health care product that preparation causes pain disease because of mycotic infection.
Background technique
Modern medicine thinks that the pathogenesis of pain disease is extremely complex, and the cause of disease is not yet clear.Ache currently used for treatment
The drug of pain disease mainly has town pain medicine opium alkaloids bases (morphine), meperidine etc. and antipyretic-antalgic anti-inflammatory agent Ah Si
Woods, brufen etc., gout suppressant Allopurinol, probenecid, colchicin etc., side effect is big, and adverse reaction is more, has habituation
Property.Science of TCM formulas thinks that " Decoction of Notopterygium for Rheumatism " has effects that analgesic, but has no that it has treatment because mycotic infection causes to ache
The document report of pain disease does not also see bulk pharmaceutical chemicals Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, rhizoma ligustici, radix saposhnikoviae, Radix Glycyrrhizae, the wild pepper of " Decoction of Notopterygium for Rheumatism "
The chemical component alkaloid and volatile oil contained in son, Rhizoma Chuanxiong is in preparation treatment because mycotic infection causes the Related Drug of pain disease
The document report of object.And the patent " pathogenic factor and Chinese traditional treatment method that crack cancer " of inventor's previous application (application number:
201310274489.7) and " a kind of the pharmaceutical composition for the treatment of cancer and preparation method thereof " (application number:
201380075486.9, PCT/CN2013/080936) in, discuss leads to the main of cancer and various chronic diseases in detail
Pathogenic factor is fungi (mould) infection, and the main pathogenic of various pain diseases is also that mycotic infection causes.Above-mentioned patent
Mention " Decoction of Notopterygium for Rheumatism " (composition: Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, rhizoma ligustici, radix saposhnikoviae, Radix Glycyrrhizae, fructus viticis, Rhizoma Chuanxiong) be with targeting in
Bone, infection of joint mould drug, overall pain disease caused by can treat because of mycotic infection bone, joint can also be with
Overall pain disease caused by treating because of cancer metastasis.Therefore the application will on this basis continuation application with " Decoction of Notopterygium for Rheumatism "
For the drug or health care product of pharmaceutical composition pain disease caused by preparation treatment is because of fungal infection of basic bulk pharmaceutical chemicals plus-minus
In application.
Summary of the invention
The purpose of the present invention is to provide a kind of pharmaceutical compositions for treating pain disease, are characterized in particular in offer by " Rhizoma Et Radix Notopterygii
Win wet soup " (composition: Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, rhizoma ligustici, radix saposhnikoviae, Radix Glycyrrhizae, fructus viticis, Rhizoma Chuanxiong) be basic bulk pharmaceutical chemicals plus-minus composition drug
Composition is in the drug of preparation treatment pain disease as caused by mould or the new application of health care product.
Further, the present invention also provides the bulk pharmaceutical chemicals Rhizoma Et Radix Notopterygiis of the pharmaceutical composition, Radix Angelicae Pubescentis, rhizoma ligustici, radix saposhnikoviae, Radix Glycyrrhizae, climing
The active chemical of the antifungi analgesic of Jing Zi, Rhizoma Chuanxiong is alkaloid and volatile oil.
Further, the present invention also provides the bulk pharmaceutical chemicals alternatives of the pharmaceutical composition to increase bulk pharmaceutical chemicals Rhizoma Gastrodiae, prolongs recklessly
The active chemical of rope, galangal, monkshood, pepper, piper cubeba, the antifungi analgesic of each bulk pharmaceutical chemicals is alkaloid and volatilization
Oil.
Further, the present invention also provides the weight ranges of each bulk pharmaceutical chemicals of the pharmaceutical composition are as follows: 1~50 part of Rhizoma Et Radix Notopterygii,
1~50 part of Radix Angelicae Pubescentis, 1~50 part of rhizoma ligustici, windproof 1~50 part, 1~50 part of Radix Glycyrrhizae, 1~50 part of fructus viticis, Rhizoma Chuanxiong 1~50 part, day
Numb 1~50 part, 0~50 part of rhizoma corydalis, 0~50 part of galangal, 0~50 part of monkshood, 0~50 part of pepper, 0~50 part of piper cubeba.
Its preferred parts by weight are as follows: 15 parts of Rhizoma Et Radix Notopterygii, 15 parts of Radix Angelicae Pubescentis, 15 parts of rhizoma ligustici, windproof 15 parts, 10 parts of Radix Glycyrrhizae, fructus viticis
15 parts, 15 parts of Rhizoma Chuanxiong, 15 parts of Rhizoma Gastrodiae, 15 parts of rhizoma corydalis, 10 parts of galangal, 15 parts of monkshood, 15 parts of pepper, 15 parts of piper cubeba.
The pharmaceutical composition for being used to treat the pain disease as caused by mould, preparation method are as follows: extract bulk pharmaceutical chemicals
Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, rhizoma ligustici, radix saposhnikoviae, Radix Glycyrrhizae, fructus viticis, Rhizoma Chuanxiong, the active chemical alkaloid contained in Rhizoma Gastrodiae and (or) volatilization
Oil and other effective components are prepared by mixing into biological agent in proportion.
The pharmaceutical composition for being used to treat the pain disease as caused by mould, preparation method are as follows: extract bulk pharmaceutical chemicals
Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, rhizoma ligustici, radix saposhnikoviae, Radix Glycyrrhizae, fructus viticis, Rhizoma Chuanxiong, Rhizoma Gastrodiae or rhizoma corydalis or galangal or monkshood or pepper or piper cubeba
In the active chemical alkaloid that contains and (or) volatile oil and other effective components be prepared by mixing into biological system in proportion
Agent.
The pharmaceutical composition for treating the pain disease as caused by mould can be made into pharmaceutically acceptable dosage form,
Such as, but not limited to tablet, soft capsule, powder, oral solution, syrup, granule, pill, powder-injection or injection, preparation side
Method prepares the conventional method of biological agent using the modern times.
It is described for treating the pharmaceutical composition of the pain disease as caused by mould, adaptation range are as follows: Medicines,
Application in terms of health food, health treatment, animal drug, animal feed.
Specific embodiment
1, a kind of pharmaceutical composition for treating the pain disease as caused by mould, preparation method are as follows: extract bulk pharmaceutical chemicals Qiang
Work, Radix Angelicae Pubescentis, rhizoma ligustici, radix saposhnikoviae, Radix Glycyrrhizae, fructus viticis, Rhizoma Chuanxiong, the chemical component alkaloid contained in Rhizoma Gastrodiae and volatile oil and other
Effective component is mixed and made into biological agent in proportion, and preparation method prepares the conventional method of biological agent, agent using the modern times
Type be pharmaceutically acceptable dosage form, such as, but not limited to tablet, soft capsule, powder, oral solution, syrup, granule, pill,
Powder-injection or injection.
2, a kind of pharmaceutical composition for treating the pain disease as caused by mould, preparation method are as follows: extract bulk pharmaceutical chemicals Qiang
Work, Radix Angelicae Pubescentis, rhizoma ligustici, radix saposhnikoviae, Radix Glycyrrhizae, fructus viticis, Rhizoma Chuanxiong, the chemical component alkaloid contained in Rhizoma Gastrodiae are mixed and made into life in proportion
Object preparation, preparation method prepare the conventional method of biological agent using the modern times, and dosage form is pharmaceutically acceptable dosage form, example
Such as, but not limited to, tablet, soft capsule, powder, oral solution, syrup, granule, pill, powder-injection or injection.
3, a kind of pharmaceutical composition for treating the pain disease as caused by mould, preparation method are as follows: extract bulk pharmaceutical chemicals Qiang
Work, Radix Angelicae Pubescentis, rhizoma ligustici, radix saposhnikoviae, Radix Glycyrrhizae, fructus viticis, Rhizoma Chuanxiong, the chemical component volatile oil contained in Rhizoma Gastrodiae are mixed and made into life in proportion
Object preparation, preparation method prepare the conventional method of biological agent using the modern times, and dosage form is pharmaceutically acceptable dosage form, example
Such as, but not limited to, tablet, soft capsule, powder, oral solution, syrup, granule, pill or externally applied liniment.
4, a kind of pharmaceutical composition for treating the pain disease as caused by mould, preparation method are to extract bulk pharmaceutical chemicals Qiang
In work, Radix Angelicae Pubescentis, rhizoma ligustici, radix saposhnikoviae, Radix Glycyrrhizae, fructus viticis, Rhizoma Chuanxiong, Rhizoma Gastrodiae or rhizoma corydalis or galangal or monkshood or pepper or piper cubeba
The active chemical alkaloid and volatile oil and other effective components contained is prepared by mixing into biological agent in proportion.It is made
Preparation Method prepares the conventional method of biological agent using the modern times, and dosage form is pharmaceutically acceptable dosage form, such as, but not limited to
Tablet, soft capsule, powder, oral solution, syrup, granule, pill, powder-injection or injection.
5, a kind of pharmaceutical composition for treating the pain disease as caused by mould, preparation method are to extract bulk pharmaceutical chemicals Qiang
In work, Radix Angelicae Pubescentis, rhizoma ligustici, radix saposhnikoviae, Radix Glycyrrhizae, fructus viticis, Rhizoma Chuanxiong, Rhizoma Gastrodiae or rhizoma corydalis or galangal or monkshood or pepper or piper cubeba
The active chemical alkaloid contained is prepared by mixing into biological agent in proportion.Preparation method is using modern preparation biology system
The conventional method of agent, dosage form be pharmaceutically acceptable dosage form, such as, but not limited to tablet, soft capsule, powder, oral solution,
Syrup, granule, pill, powder-injection or injection.
6, a kind of pharmaceutical composition for treating the pain disease as caused by mould, preparation method are to extract bulk pharmaceutical chemicals Qiang
In work, Radix Angelicae Pubescentis, rhizoma ligustici, radix saposhnikoviae, Radix Glycyrrhizae, fructus viticis, Rhizoma Chuanxiong, Rhizoma Gastrodiae or rhizoma corydalis or galangal or monkshood or pepper or piper cubeba
The active chemical volatile oil contained is prepared by mixing into biological agent in proportion.Preparation method is using modern preparation biology system
The conventional method of agent, dosage form be pharmaceutically acceptable dosage form, such as, but not limited to tablet, soft capsule, powder, oral solution,
Syrup, granule, pill or externally applied liniment.
Pathway of Creation of the invention is since the research of Jin Dynasty name doctor Zhang Yuansu " headache case ", to crack China
Ancient times traditional culture " the theory of yin-yang and five elements (metal, wood, water, fire and earth) ".Another application for cracking content and being specifically shown in me to " yin-yang and five elements "
" yin-yang and five elements " and modern doctor are described in 201410299118.9 " a kind of pharmaceutical compositions of wide spectrum anaerobe resistant " in detail
Relationship." the theory of yin-yang and five elements (metal, wood, water, fire and earth) " is the basis of ancient Chinese medicine theory.Because germ of the existence in yin channel is known as " yin by ancients
It is evil ", " yin is evil " is divided into " damp evil " and " cold-evil " again.The inspiration that I is cracked " yin and yang xue " is thought: " yin channel " described in Chinese medicine
In " damp evil " be the various anaerobic bacterias (including fungi) for having tolerance to anoxic to survive in vein, " cold-evil " is then true
Bacterium (mould).Because fungi is most strong in all anaerobic bacterias to the tolerance of anoxic, the intracorporal various germs of humans and animals
Between the final result mutually struggled against be that fungi is won, this leads to the mankind and animal unusual death that is to say, bright fungi is only
Real arch-criminal is the principal element for leading to various chronic diseases and cancer.It is vein by " yin channel ", is with fungi by " damp evil "
Anaerobic bacteria based on (mould) is inspired, and by " cold-evil " is the inspiration of fungi (mould), to show that " clearing damp medicine, cold-dispelling drug " has
The effect of antimycotic (mould).It is inspired by the characteristic that mould happiness acid detests alkali, show that the alkaloid contained in botanical drug substance is
Antimycotic main chemical compositions, and by the inspiration of Chinese medicine " removing dampness by means of aromatics, pungent cold with dampness elimination, Wen Yihua ", obtain plant material
Volatile oil in medicine is also antimycotic chemical component.
" Decoction of Notopterygium for Rheumatism " belongs to " dampclearing prescription ", and function is wind-dispelling, wins wet, analgesic.Therefore have the function for the treatment of mould.
Rhizoma Et Radix Notopterygii, radix saposhnikoviae, rhizoma ligustici ownership " wind-cold-dispersing medicinal ", " wind refers to ailment said due to cold or exposure ", i.e., by the germ of infection through air, and air
In contain a large amount of moulds, therefore " anemofrigid cold " refers to that the anaerobic bacteria based on mould passes through flu caused by infection through air.
Rhizoma Et Radix Notopterygii, radix saposhnikoviae, rhizoma ligustici contain volatile oil and alkaloid, have antimycotic effect.
Radix Angelicae Pubescentis belongs to " wind-dispelling cold-dampness medicine ", contains volatile oil and alkaloid, has antimycotic effect.
Fructus viticis belongs to " wind-heat-dispersing medicinal ", and pharmacological property is pungent, bitter, slightly cold, controls anemopyretic cold, dizzy headache, is dispelling wind evil medicine,
Fructus viticis contains volatile oil and alkaloid, it may have antimycotic effect.
Glycyrrhiza qi-restoratives medicine, and the cause of disease of " spleen deficiency " is " humidity hysteresis taste ", therefore Radix Glycyrrhizae is also that can treat " damp evil "
Drug, containing alkaloids and volatile oil, i.e. Radix Glycyrrhizae have antimycotic effect.
Rhizoma Chuanxiong, rhizoma corydalis ownership " drug for invigorating blood circulation and eliminating stasis ", cure mainly " rheumatic arthralgia ", their containing alkaloids and volatile oil, because
This also has antimycotic effect.And mould mainly forms the obstruction blood circulation of mould group, so dredging vascellum is analgesic
Main application principle.
Rhizoma Gastrodiae is " Inflammation Zhijing medicine ", " wind refers to ailment said due to cold or exposure ", i.e., by the germ of infection through air, and containing a large amount of mould in air
Bacterium, therefore Rhizoma Gastrodiae has antimycotic effect, and its alkaloid for containing and volatile oil have stronger Antifungal activities.
Monkshood, galangal, pepper, piper cubeba category cold-dispelling drug (drugs for dispelling internal cold) contain alkaloid and volatile oil, therefore have anti-mildew
The effect of bacterium.
Therefore bulk pharmaceutical chemicals Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, rhizoma ligustici, radix saposhnikoviae, Radix Glycyrrhizae, fructus viticis, Rhizoma Chuanxiong, Rhizoma Gastrodiae, rhizoma corydalis, galangal, attached
Son, pepper, piper cubeba general character be to all have antimycotic effect, antimycotic active chemical is alkaloid and volatilization
Oil, their characteristics, which will be different bulk pharmaceutical chemicals, will all have antimycotic drug connection with targeting in the mould of different parts
Closing use can be enhanced curative effect, plays team role, and can reduce side effect, avoids producing because single raw material survival dose is excessive
Toxigenicity reaction.
Creativeness and novelty of the invention
Since Pathway of Creation of the invention be the " yin-yang and five elements cracking Chinese ancient traditional culture " the theory of yin-yang and five elements (metal, wood, water, fire and earth) "
Theory " be ancient Chinese medicine theory basis.Because germ of the existence in yin channel is known as " yin is evil " by ancients, " yin is evil " is divided into again "
Damp evil " and " cold-evil ".It will be argued that cracking for " yin and yang xue ": " yin channel " described in Chinese medicine inner " damp evil " is existence quiet
The anaerobic bacteria (including mould) for having tolerance to anoxic in arteries and veins, " cold-evil " are then mould.Again because mould is fungi, to anoxic
Tolerance it is most strong in all anaerobic bacterias, therefore the final result mutually struggled against between the intracorporal various germs of humans and animals is
Mould is won, this is to lead to cancer and each that is to say, bright mould is only the real arch-criminal for leading to the mankind and animal unusual death
The principal element of kind chronic disease, and lead to one of the principal element of various pain diseases.
It will be argued that cracking for " five-element ": germ causes pathology after mutual restriction of five phases relationship then indicates human infection germ
The transfer process of reaction.Mutual restriction of five phases relationship are as follows: metal restricting wood, Wood restricts earth, earth restricting water, water restricting fire, fire restricting metal.I cracks " gold "
For the dissection figure of lung, " wood " indicates twelve channels and collaterals whole body distribution map, the i.e. distribution map of system vascular." soil " is the solution of liver
Figure is cutd open, " water " is the dissection figure of two kidneys and urinary system, and " fire " is the dissection figure of heart.
Therefore, it will be argued that: metal restricting wood: after germ passes through respiratory tract infection lung, into systemic blood circulation system,
The capillary end delay of hand, foot, head.The germ of the especially upper respiratory tract is easily accessible brain capillary.
Wood restricts earth: the germ in blood shifts and rests in liver and breeds, and liver is made substantive pathological change occur.
Earth restricting water: after invading liver, germ is next, and cause pathological change is kidney.
Water restricting fire: it after substantive pathological change occurs in kidney, is over heart and substantive pathological change occurs.
Fire restricting metal: it after pathological change occurs in heart, is finally only lung and solid lesion occurs.This is because lung is
The oxygen content of the organ of a opening, inner face is most abundant, and anaerobic bacteria is small to its destructive power, this also illustrates that patient is finally often
Die of respiratory failure.
So I determines: ancient Chinese doctor has found the pathology transfer process of anaerobic bacteria (including mould) are as follows: respiratory tract
Infection (entering artery) → systemic blood circulation (head, hand, foot capillary end) → vena hepatica → renal vein → cardiac veins
→ pulmonary vein.The negative analysing and differentiating of febrile disease in accordance with the theory of the six pair of channels of three sun three of treatise on Febrile Diseases is exactly to be discussed according to the path of mutual restriction of five phases.Therefore treatment disease
Disease also should determine therapeutic scheme according to the development process of disease.Firstly, various germs enter the dynamic of the upper respiratory tract by air
Arteries and veins, human body show as catching a cold, so active treatment flu is the key that the various diseases of prevention.Wherein gram-positive bacteria is fallen ill
It is anxious, prevent or cure a disease also fast, because they can not be lived and reproduced in vein.Only various anaerobic bacterias could live and reproduce in vein,
And only have fungi to be only last victor in anaerobic bacteria.So fungi be only cause various chronic diseases and cancer it is main because
Element.
The present invention has also obtained the verifying of modern western scientific medical to cracking for " the theory of yin-yang and five elements (metal, wood, water, fire and earth) ".In the another of the applicant
One patent: be discussed in detail in " a kind of Chinese medicine for treating deep fungal infection " modern western scientific medical to the research of fungi at
Fruit.
By " infectious diseases practice guidelines " the 3rd edition record of Qi Junying, Tian Deying chief editor: in recent years, with west
Further investigation of the medical field to infectious diseases, especially to the continuous of deep fungal infection disease studies have shown that candida albicans can
It invades each tract of whole body and causes corresponding clinical manifestation, such as pulmonary candidiasis, renal candidiasis, the monilial internal membrane of heart
Scorching, marrow and arthritis, meningitis, or even involve multiple internal organs and lead to serious disseminated candidiasis.These researchs have shown that
I to cracking for " mutual restriction of five phases " is correct.
Medical research in recent years also turns out that the route of infection of aspergillosis is mainly the spore sucked in air, aspergillus spore
Enter nasal sinus and lung with breathing, sprouts generation mycelia and enter cell qualitative change, aspergillus hobby intrusion blood vessel.This research also demonstrates
My parsing to " metal restricting wood ": after germ is by respiratory tract infection lung and nasal sinus, into systemic blood circulation system,
Hand, foot, head capillary end be detained, the germ of the especially upper respiratory tract is easily accessible brain capillary, often have headache,
The symptoms such as nasal obstruction, it is closely similar with the anemofrigid cold symptom of Chinese medicine.
Medical research in recent years also turns out that the fungies major transmission path such as cryptococcosis, mucormycosis is respiratory tract and skin
Skin can lead to systemic cryptococcosis；Nose brain mucormycosis, lung mucormycosis, stomach and intestine mucormycosis, dissemination mucormycosis etc..
Medical research in recent years shows that the clinical manifestation of fungi deep infection disease does not have specificity, imageological examination
The prompt images such as focal lesion image and bacterium infection, tuberculosis, tumour do not have specificity.Obtaining Etiological Evidence is antidiastole
Key.
Therefore modern medicine can prove me to " yin-yang and five elements " theory the research achievement of deep fungal infection disease
It is correctly, to also turn out and it will be argued that " anemofrigid cold " is primarily referred to as having infected from air with " damp evil ", cracking for " cold-evil "
In mould caused by catch a cold inference be correct.Also turning out it will be argued that: the process from " wet poison disease " to " sympotoms caused by cold factors " is
Pathological change process and fungi from superficial infection fungi to deep fungal infection lead to the pathological change of various chronic diseases
Process and fungi cause the process of cancer and fungi to lead to the Etiologicals of various pain diseases.Modern western scientific medical pair
The research of fungi can prove that my inference is correct.
" skin cypridology ", which also has proven to candida albicans, to cause skin, mucous membrane and internal organ, bone by external source or endogenous pathway
The infection of bone, brain.Modern medicine thinks that Candida albicans is one of human normal parasitism flora, is conditioned pathogen, and recognize
It is in commensalism with human body under normal operation for Candida albicans, and not pathogenic.It will be argued that this be it is wrong, it is not
Have it is static, but always in the whole body for slowly corroding us.Only when resistance declines, it is become active by latent, is made
Symptom is obvious.That is canceration is a very very long process, is a process by quantitative change to qualitative change.Change in period
The life condition of mould, so that it may extend the time of canceration.
Therefore existing technical background is: the viewpoint of modern western scientific medical thinks: fungal infection belongs to infectious diseases
One kind, fungi are the suprainfections of the patients such as cancer, immune deficiency, organ transplant, are the relationships of complication, and mould is that condition causes
Germ.
Creativeness of the invention and novelty are: I am by cracking to " yin-yang and five elements ", it is believed that fungi, which is only, to cause
The main pathogenic of various chronic diseases and cancer, and more than simple one of infectious diseases, nor cancer,
The suprainfection of the patients such as immune deficiency, organ transplant or the relationship of complication.And it is additionally considered that current people are thought in person
Those of carcinogenic factor be risk factor, that is, external cause in fact.When tissue, cell, blood, the organ of external cause damage human body
When, cause blood circulation to be obstructed, in the state of anoxic, induces intracorporal fungi and cause various in damaged part mass propagation
Disease, and further result in cancer.
So applicants contemplate that the fungi (mould) that modern western scientific medical is thought is one small point of infectious diseases
The viewpoint of branch is defective, modern western scientific medical think fungi and cancer relationship be the relationship of suprainfection, be complication pass
System, fungi are that the viewpoint of conditioned pathogen also has limitation or one-sidedness.Creativeness of the invention is: think canceration its
It is exactly in fact to go mouldy, cancer is exactly mould pathological change process from quantitative change to qualitative change, when the pathology that mould breeds in human body becomes
The clinical symptoms of change process reflection are exactly various chronic diseases, thus obtain creative conclusion be exactly fungi be exactly cause it is various slow
The main pathogenic of property disease and cancer.Fungi is also the main pathogenic for leading to pain disease.
The only anaerobism for just as the principle of fermentation, being various germs at the beginning and depositing, but can survive in vein
Bacterium, and only have the vitality of fungi most strong in various anaerobic bacterias, destructive power is also most strong, and canceration is exactly that mould is from quantitative change to qualitative change
Process, the clinical symptoms embodied during this quantitative change are exactly the symptom of various chronic diseases.When there are cancer symptoms, in vivo
Only fungi accounts for absolute leading position.Therefore fungi is the main pathogenic for leading to cancer and various chronic diseases.The application
People is inspired by the characteristic that mould happiness acid detests alkali, show that the alkaloid that botanical drug substance contains is antimycotic main chemical compositions,
Again by the inspiration of Chinese medicine " removing dampness by means of aromatics, pungent cold with dampness elimination, Wen Yihua ", show that the volatile oil that botanical drug substance contains is also anti-mildew
The chemical component of bacterium.
So the creativeness and novelty of pharmaceutical composition provided by the invention are shown: by bulk pharmaceutical chemicals Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, ligusticumic
The pharmaceutical composition that sheet, radix saposhnikoviae, Radix Glycyrrhizae, fructus viticis, Rhizoma Chuanxiong, Rhizoma Gastrodiae, rhizoma corydalis, galangal, monkshood, pepper, piper cubeba form
Pharmacological action be the drug for treating the various pain diseases as caused by mould, the main anti-mildew of each bulk pharmaceutical chemicals in pharmaceutical composition
The active chemical of bacterium is alkaloid and volatile oil.
So Pathway of Creation of the invention is that ancient Chinese medicine theory is docked with modern western scientific medical theory, make ancient Chinese medicine
Theory is mutually authenticated between the two with modern western scientific medical theory, melts ancient Chinese medicine theory with modern western scientific medical theory
It can penetrate through, more make ancient Chinese medicine theory to going a step further before modern scientific theory.The research of Needham, Noel Joseph Terence Montgomery research institute, univ cambridge uk
" Science And Civilization in China " in speak of recorded in the Exploitation of the Works of Nature of SONG Yingxing many techniques be how application technology, how to give birth to
It produces, the dosage ratio etc. of each raw material, but does not illustrate the application principle of these technologies.Therefore Needham, Noel Joseph Terence Montgomery research institute thinks China
It is technology prosperity, science is not kept up with, and four invents by China are technologies rather than scientific.Because of the intension of science and technology
It is different.Science is to test with mathematics as a whole set of complete scientific system of representative, it is metaphysics, is abstract
's.And technology is the summary of labourer experience and wisdom in process of production.Traditional Chinese medicine is also in this way, failing always
The application principle of bright traditional Chinese medicine can not be said because traditional Chinese medicine cannot illustrate the active chemical of various Chinese medicines
Its bright medicinal principle, can not illustrate the mechanism and pharmacology of various plant combined medications.And invention solves these problems.
It is that mould is cracked to main pathogenic, makes medically many problems that can obtain reasonably logical parsing, explanation
The application principle of traditional Chinese medicine, thus the present invention makes ancient Chinese medicine theory to going a step further before modern scientific theory.
Technical effect
It is safely and effectively that traditional classical prescription " Decoction of Notopterygium for Rheumatism ", which has been clinically proven,.Pharmaceutical composition provided by the invention is
The extract of bulk pharmaceutical chemicals based on traditional classical prescription " Decoction of Notopterygium for Rheumatism " extracts bulk pharmaceutical chemicals Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, rhizoma ligustici, radix saposhnikoviae, sweet
Grass, fructus viticis, Rhizoma Chuanxiong, Rhizoma Gastrodiae, rhizoma corydalis, galangal, monkshood, pepper, the volatile oil contained in piper cubeba and alkaloid by than
Example is prepared by mixing into the drug or health care product for the treatment of pain disease as caused by mould.Because of drug provided by the invention or health care product
Specific chemical components, compared to traditional pharmaceutical methods, validity is obvious.
And I applies Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, rhizoma ligustici, radix saposhnikoviae, Radix Glycyrrhizae, fructus viticis, Rhizoma Chuanxiong, Rhizoma Gastrodiae or rhizoma corydalis or galangal
Or the Chinese medicine conventional prescriptions of monkshood or pepper or piper cubeba combination, it is obtained well using the method treatment pain disease of water decoction
Effect.Drug or health care product provided by the invention take modern pharmaceutical method to extract chemical component alkaloid and (or) volatile oil
Pharmacy is mixed in proportion, and validity is obvious.
Claims (6)
1. a kind of treat the pharmaceutical composition for leading to pain disease by mould, it is characterised in that the bulk pharmaceutical chemicals in pharmaceutical composition
Are as follows: 1~50 part of Rhizoma Et Radix Notopterygii, 1~50 part of Radix Angelicae Pubescentis, 1~50 part of rhizoma ligustici, radix saposhnikoviae 1~50 part, 1~50 part of Radix Glycyrrhizae, 1~50 part of fructus viticis,
1~50 part of Rhizoma Chuanxiong, 1~50 part of Rhizoma Gastrodiae, 0~50 part of rhizoma corydalis, 0~50 part of galangal, 0~50 part of monkshood, 0~50 part of pepper,
0~50 part of piper cubeba, the active chemical of the antifungi analgesic of each bulk pharmaceutical chemicals is alkaloid and volatile oil.
2. pharmaceutical composition as described in claim 1, it is characterised in that the preferred parts by weight of pharmaceutical composition are as follows: Rhizoma Et Radix Notopterygii 15
Part, 15 parts of Radix Angelicae Pubescentis, 15 parts of rhizoma ligustici, windproof 15 parts, 10 parts of Radix Glycyrrhizae, 15 parts of fructus viticis, 15 parts of Rhizoma Chuanxiong, 15 parts of Rhizoma Gastrodiae, rhizoma corydalis 15
Part, 10 parts of galangal, 15 parts of monkshood, 15 parts of pepper, 15 parts of piper cubeba.
3. pharmaceutical composition as claimed in claim 1 or 2, it is characterised in that pharmaceutical composition the preparation method comprises the following steps: extracting former
Expect medicine Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, rhizoma ligustici, radix saposhnikoviae, Radix Glycyrrhizae, fructus viticis, Rhizoma Chuanxiong, Rhizoma Gastrodiae or rhizoma corydalis or galangal or monkshood or pepper or Bi
The active chemical alkaloid and volatile oil and other effective components contained in clear eggplant is prepared by mixing into biological system in proportion
Agent, preparation method prepare the conventional method of biological agent using the modern times, and dosage form can be made into pharmaceutically acceptable dosage form, example
Such as, but not limited to, tablet, soft capsule, powder, oral solution, syrup, granule, pill, powder-injection or injection.
4. pharmaceutical composition as claimed in claim 1 or 2, it is characterised in that pharmaceutical composition the preparation method comprises the following steps: extracting former
Expect medicine Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, rhizoma ligustici, radix saposhnikoviae, Radix Glycyrrhizae, fructus viticis, Rhizoma Chuanxiong, Rhizoma Gastrodiae or rhizoma corydalis or galangal or monkshood or pepper or Bi
The active chemical alkaloid contained in clear eggplant is prepared by mixing into biological agent in proportion, and preparation method is using modern preparation
The conventional method of biological agent, dosage form can be made into pharmaceutically acceptable dosage form, such as, but not limited to tablet, soft capsule, dissipate
Agent, oral solution, syrup, granule, pill, powder-injection or injection.
5. pharmaceutical composition as claimed in claim 1 or 2, it is characterised in that pharmaceutical composition the preparation method comprises the following steps: extracting former
Expect medicine Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, rhizoma ligustici, radix saposhnikoviae, Radix Glycyrrhizae, fructus viticis, Rhizoma Chuanxiong, Rhizoma Gastrodiae or rhizoma corydalis or galangal or monkshood or pepper or Bi
The active chemical volatile oil contained in clear eggplant is prepared by mixing into biological agent in proportion, and preparation method is using modern preparation
The conventional method of biological agent, dosage form can be made into pharmaceutically acceptable dosage form, such as, but not limited to tablet, soft capsule, dissipate
Agent, oral solution, syrup, granule, pill, externally applied liniment.
6. the pharmaceutical composition as described in claims 1 or 2 or 3 or 4 or 5, it is characterised in that the adaptation range of pharmaceutical composition
Are as follows: the application in terms of Medicines, health food, health treatment, animal drug, animal feed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811607664.9A CN109464605A (en) | 2018-12-18 | 2018-12-18 | It is a kind of to treat the pharmaceutical composition for leading to pain disease by mould |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811607664.9A CN109464605A (en) | 2018-12-18 | 2018-12-18 | It is a kind of to treat the pharmaceutical composition for leading to pain disease by mould |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109464605A true CN109464605A (en) | 2019-03-15 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811607664.9A Pending CN109464605A (en) | 2018-12-18 | 2018-12-18 | It is a kind of to treat the pharmaceutical composition for leading to pain disease by mould |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109464605A (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104784606A (en) * | 2015-04-13 | 2015-07-22 | 梁晓 | Traditional Chinese medicine composition for treating cold-damp type lumbar muscle degeneration |
-
2018
- 2018-12-18 CN CN201811607664.9A patent/CN109464605A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104784606A (en) * | 2015-04-13 | 2015-07-22 | 梁晓 | Traditional Chinese medicine composition for treating cold-damp type lumbar muscle degeneration |
Non-Patent Citations (1)
| Title |
|---|
| 邓中甲: "《方剂学》", 31 March 2017 * |
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Application publication date: 20190315 |