CN109331069A - Application of the monkshood alkaloid in the drug for preparing anti-deep fungal infection - Google Patents
Application of the monkshood alkaloid in the drug for preparing anti-deep fungal infection Download PDFInfo
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- 150000003797 alkaloid derivatives Chemical class 0.000 title claims abstract description 20
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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Abstract
The invention belongs to medical health fields, are related to traditional Chinese medicine monkshood in the new application of the drug of preparation treatment deep fungal infection, and in particular to new application of the monkshood alkaloid in the drug for preparing anti-deep fungal infection.
Description
Divisional application
The application is a kind of original application " Chinese medicine for treating deep fungal infection " (application number: point 201510807777.3)
Case application, the applying date of original application are on November 20th, 2015.
Technical field
The invention belongs to medical health fields, are related to traditional Chinese medicine monkshood in preparation and treat the drug of deep fungal infection
New application, and in particular to new application of the monkshood alkaloid in the drug for preparing anti-deep fungal infection.
Background technique
Nosomycosis is divided into superficial mycoses and deep mycosis two major classes by modern medicine.Superficial mycoses refers to skin angle
Albumen tissue (including cuticula, deck, hair etc.) infection.Deep mycosis is also studies of invasive fungal infections (IFD), refers to fungi
Human body is invaded, grows, breed in tissue, organ or blood, and lead to the disease of inflammatory reaction and tissue damage.In recent years,
Since malignant tumour, immune deficiency, transplant patient's number increase, a large amount of uses and invasive monitoring of broad-spectrum antibiotic with
The extensive utilization for the treatment of means, the sufferer of fungi deep infection are in continue ascendant trend, seriously threaten the life security of the mankind.But
It is considerably less to the research of fungi deep infection at present, and now on the market for treating the drug of fungi deep infection, often
Side effect is big, and long-time service damages organ, and curative effect is also undesirable, while generating many adverse reactions.Hair
A kind of bright people's earlier patent application " Chinese medicine for treating deep fungal infection " (application number: in 201510807777.3), is discussed
The method that gastrodia elata, the tuber of pinellia, monkshood are used to treat fungi, but because being related to multiple independent claims, auditor's sending
" first time notification of examiner's opinion " (it is single 2018110101913730) dispatch serial number: to think that claim 1-10 does not have
Property.Therefore the requirement of auditor is answered to carry out divisional application on the basis of former claim 8.
Pathway of Creation of the invention is since the research of Jin Dynasty name doctor Zhang Yuansu " headache case ", to crack China
Ancient times traditional culture " the theory of yin-yang and five elements (metal, wood, water, fire and earth) "." the theory of yin-yang and five elements (metal, wood, water, fire and earth) " is also the basis of ancient Chinese medicine theory.Because ancients are existence
Germ in yin channel is known as " yin is evil ", and " yin is evil " is divided into " damp evil " and " cold-evil " again.I is cracked the inspiration of " yin and yang xue "
Think: " yin channel " described in Chinese medicine inner " damp evil " be survive in vein to anoxic have tolerance anaerobic bacteria (including
Fungi (mould)), " cold-evil " is then mould (fungi).Because fungi is most strong in all anaerobic bacterias to the tolerance of anoxic, because
The final result mutually struggled against between this person and the intracorporal various germs of animal is that fungi is won, this is that is to say, bright fungi is only and leads
The real arch-criminal for causing the mankind and animal unusual death, is the principal element for leading to various chronic diseases and cancer.By " yin channel "
It is vein, is that the anaerobic bacteria that can be survived in vein based on fungi is inspired by " damp evil ", is the inspiration of fungi by " cold-evil ",
To show that " damp-resolving medicinal, cold-dispelling drug " has antimycotic effect.It is inspired again by the characteristic that mould happiness acid detests alkali, obtains botanical medicine
In it is containing alkaloids be antimycotic main chemical compositions, and opened by Chinese medicine " removing dampness by means of aromatics, pungent cold with dampness elimination, Wen Yihua "
Hair, show that the volatile oil in botanical medicine is also antimycotic chemical component.Monkshood pharmacological property is pungent, hot, cures mainly wind-dispelling cold-dampness paralysis, because
This monkshood has the function of dampness elimination dispelling cold, has antimycotic effect, alkaloid is main antimycotic active constituent.
Summary of the invention
The purpose of the present invention is to provide the new applications that monkshood is used to treat deep fungal infection, are characterized in particular in and provide monkshood
New application of the alkaloid in the drug for preparing anti-deep fungal infection.
Further, the present invention also provides the chemical component alkaloids for extracting monkshood, and injection is made using modern pharmaceutical method
Powder-injection.
Further, the present invention also provides the chemical component alkaloids that can extract monkshood to be made of modern pharmaceutical method
The powder-injection of injection.
The monkshood or Radix Aconiti Lateralis Preparata alkaloid are used for the drug of anti-deep fungal, and adaptation range includes: in Medicines, moves
The application of object pharmaceutical preparations.
Specific embodiment
New opplication of the monkshood alkaloid in the drug for preparing anti-deep fungal infection, it is characterised in that extract the chemistry of monkshood
The powder-injection of injection is made of modern pharmaceutical method for ingredients Biogenic alkali.
New opplication of the Radix Aconiti Lateralis Preparata alkaloid in the drug for preparing anti-deep fungal infection, it is characterised in that extract the chemistry of monkshood
The powder-injection of injection is made of modern pharmaceutical method for ingredients Biogenic alkali.
Division foundation
The claim of this divisional application be by parent application " a kind of Chinese medicine for treating deep fungal infection " (application number:
201510807777.3) it is recorded in the claim 8 in claims: using modern pharmaceutical method Rhizoma Gastrodiae, the tuber of pinellia, river
The alkaloid of crow is individually prepared into the powder-injection of injection.River of the foundation of the application division in former claim 8
Black alkaloid is prepared into the powder-injection of injection.
Increase and " extracts the powder-injection that injection is made of modern pharmaceutical method for Radix Aconiti Lateralis Preparata alkaloid." foundation see that female case is said
The record of bright book [0051] section: can substitute monkshood with monkshood, and monkshood be the sub- root of the rhizome of Chinese monkshood, and monkshood is female root of the rhizome of Chinese monkshood, monkshood,
Monkshood contains a variety of alkaloids, mainly various aconitines.
Creativeness and novelty of the invention
Since Pathway of Creation of the invention be the " yin-yang and five elements cracking Chinese ancient traditional culture " the theory of yin-yang and five elements (metal, wood, water, fire and earth) "
Theory " be also ancient Chinese medicine theory basis.Because germ of the existence in yin channel is known as " yin is evil " by ancients, " yin is evil " divides again
For " damp evil " and " cold-evil ".It will be argued that cracking for " yin and yang xue ": " yin channel " described in Chinese medicine inner " damp evil " is existence
The anaerobic bacteria (including fungi) for having tolerance to anoxic in vein, " cold-evil " are then fungi.Tolerance of the fungi to anoxic
It is most strong in all anaerobic bacterias, therefore the final result mutually struggled against between the intracorporal various germs of humans and animals is mould victory
Out, this is the principal element for leading to cancer that is to say, bright fungi is only the real arch-criminal for leading to the mankind and animal unusual death.
It will be argued that cracking for " five-element ": germ causes pathology after mutual restriction of five phases relationship then indicates human infection germ
The transfer process of reaction.Mutual restriction of five phases relationship are as follows: metal restricting wood, Wood restricts earth, earth restricting water, water restricting fire, fire restricting metal.I cracks " gold "
For the dissection figure of lung, " wood " indicates twelve channels and collaterals whole body distribution map, the i.e. distribution map of system vascular." soil " is the solution of liver
Figure is cutd open, " water " is the dissection figure of two kidneys and urinary system, and " fire " is the dissection figure of heart.
So I determines: ancient Chinese doctor has found the pathology transfer process of anaerobic bacteria (including mould) are as follows: respiratory tract
Infection (entering artery) → systemic blood circulation (head, hand, foot capillary end) → vena hepatica → renal vein → heart → lung
Vein.
The present invention has also obtained the verifying of modern western scientific medical to cracking for " the theory of yin-yang and five elements (metal, wood, water, fire and earth) ".Modern medicine is to deep
The research achievement of fungal infection disease can prove that I am theoretical to " yin-yang and five elements " and " damp evil ", cracking for " cold-evil " are correct
, also turn out that the inference that it will be argued that " anemofrigid cold " then refers to flu caused by having infected the mould in air is correct
's.Also turning out it will be argued that: the process from " wet poison disease " to " sympotoms caused by cold factors " is from superficial infection fungi to deep fungal infection
Pathological change process and fungi cause the pathological change process of various chronic diseases and fungi to lead to the process of cancer, institute
My inference, which is correct, to be proved to the research of fungi with modern western scientific medical.
But the viewpoint of modern western scientific medical thinks: fungal infection belongs to one kind of infectious diseases, and fungi is cancer, is immunized
The suprainfection of the patients such as defect, organ transplant, is the relationship of complication, and fungi is conditioned pathogen.
Creativeness of the invention and novelty are: I am by cracking to " yin-yang and five elements ", it is believed that fungi, which is only, to cause
The main pathogenic of various chronic diseases and cancer, and more than simple one of infectious diseases, nor cancer,
The suprainfection of the patients such as immune deficiency, organ transplant or the relationship of complication.And it is additionally considered that current people are thought in person
Those of carcinogenic factor be risk factor, that is, external cause in fact.When tissue, cell, blood, the organ of external cause damage human body
When, cause blood circulation to be obstructed, in the state of anoxic, induces intracorporal mould and cause various in damaged part mass propagation
Disease, and further result in cancer.
So applicant thinks that the fungi (mould) that modern western scientific medical is thought is a subbranch of infectious diseases
Viewpoint it is defective, modern western scientific medical think fungi and cancer relationship be the relationship of suprainfection, the relationship for being complication,
Fungi is that the viewpoint of conditioned pathogen also has limitation.Creativeness of the invention is: thinking that canceration is exactly to go mouldy in fact, cancer
It is exactly mould pathological change process from quantitative change to qualitative change, when the clinic for the pathological change process reflection that mould breeds in human body
Symptom is exactly various chronic diseases, so showing that creative conclusion be exactly fungi is exactly the master for leading to various chronic diseases and cancer
Want pathogenic factor.
The only anaerobism for just as the principle of fermentation, being various germs at the beginning and depositing, but can survive in vein
Bacterium, and only have the vitality of mould most strong in various anaerobic bacterias, destructive power is also most strong, and canceration is exactly that mould is from quantitative change to qualitative change
Process, the clinical symptoms embodied during this quantitative change are exactly the symptom of various chronic diseases.When there are cancer symptoms, in vivo
Only mould accounts for absolute leading position.Therefore fungi is the main pathogenic for leading to cancer, fungi be also cause it is various chronic
The main pathogenic of disease, fungi are also the main pathogenic for leading to the viscera diseases such as liver, spleen, pancreas, kidney,
It is the principal element for causing blood circulation to be obstructed, and the main pathogenic for causing digestive system function to decline, and causes
The main pathogenic of entire head disease.
The applicant is inspired by the characteristic that mould happiness acid detests alkali, show that the alkaloid that monkshood, monkshood contain is antimycotic
Main chemical compositions.
So the creativeness and novelty of drug provided by the invention are shown: the new pharmacological action of monkshood, monkshood is anti-
Fungal agents, the antimycotic main active chemical of monkshood, monkshood is alkaloid.
So Pathway of Creation of the invention is that ancient Chinese medicine theory is docked with modern western scientific medical theory, make ancient Chinese medicine
Theory is mutually authenticated between the two with modern western scientific medical theory, melts ancient Chinese medicine theory with modern western scientific medical theory
It can penetrate through, more make ancient Chinese medicine theory to going a step further before modern scientific theory.The research of Needham, Noel Joseph Terence Montgomery research institute of univ cambridge uk
" Science And Civilization in China " in speak of recorded in the Exploitation of the Works of Nature of SONG Yingxing many techniques be how application technology, how to give birth to
It produces, the dosage ratio etc. of each raw material, but does not illustrate the application principle of these technologies.Therefore Needham, Noel Joseph Terence Montgomery research institute thinks China
It is technology prosperity, science is not kept up with, and four invents by China are technologies rather than scientific.Because of the intension of science and technology
It is different.Science is to test with mathematics as a whole set of complete scientific system of representative, it is metaphysics, is abstract
's.And technology is the summary of labourer experience and wisdom in process of production.Traditional Chinese medicine is also in this way, failing always
The application principle of bright traditional Chinese medicine can not be said because traditional Chinese medicine cannot illustrate the active chemical of various Chinese medicines
Its bright medicinal principle, can not illustrate the mechanism and pharmacology of various plant combined medications.And invention solves these problems.
It is that fungi is cracked to pathogenic factor, makes medically many problems that can obtain reasonably logical parsing, to botanical medicine
The discovery of active chemical alkaloid and volatile oil illustrates the application principle of traditional Chinese medicine, and thus the present invention made in ancient times
Medical knowledge opinion is to going a step further before modern scientific theory.
Technical effect
It is safely and effectively that traditional Chinese medicine monkshood, monkshood, which have been clinically proven,.Drug provided by the invention is in tradition
The extract of bulk pharmaceutical chemicals based on herbal medicine, extracts monkshood or powder-injection is prepared separately into Radix Aconiti Lateralis Preparata alkaloid.Because the present invention provides
Drug chemistry definite ingredients, compared to traditional pharmaceutical methods, validity is obvious.
Claims (4)
1. application of the monkshood alkaloid in the drug for preparing anti-deep fungal infection.
2. application as described in claim 1, it is characterised in that extract the chemical component alkaloid of monkshood using modern pharmaceutical side
The powder-injection of injection is made in method.
3. application as described in claim 1, it is characterised in that the chemical component alkaloid for extracting monkshood and (or) monkshood uses
The powder-injection of injection is made in modern pharmaceutical method.
4. the application as described in claims 1 or 2 or 3, it is characterised in that the monkshood and (or) Radix Aconiti Lateralis Preparata alkaloid are used for anti-depth
The adaptation range of the drug of portion's fungal infection includes: the application in terms of Medicines, animal drug.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
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| CN201510807777.3A Pending CN105343565A (en) | 2015-11-20 | 2015-11-20 | Traditional Chinese medicine for treating deep fungal infection |
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| WO2021119966A1 (en) * | 2019-12-17 | 2021-06-24 | 肖鸣春 | Drug for treating digestive system mycosis |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1176110A (en) * | 1996-09-06 | 1998-03-18 | 薛弘扬 | Tinea lotion |
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| CN1176110A (en) * | 1996-09-06 | 1998-03-18 | 薛弘扬 | Tinea lotion |
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| Title |
|---|
| MAKIKO KOBAYASHI等: "The regulation of burn-associated infections with herpes simplex virus type 1 or Candida albicans by a non-toxic aconitine-hydrolysate, benzoylmesaconine Part 2: Mechanism of the antiviral action", 《IMMUNOLOGY AND CELL BIOLOGY》 * |
| 吴国泰: "甘青乌头生物碱的提取、分离和药理活性研究", 《中国博士学位论文全文数据库 农业科技辑》 * |
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| CN105343565A (en) | 2016-02-24 |
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