CN109453292A - 一种缓解中风后遗症引起的功能障碍药物 - Google Patents
一种缓解中风后遗症引起的功能障碍药物 Download PDFInfo
- Publication number
- CN109453292A CN109453292A CN201811585080.6A CN201811585080A CN109453292A CN 109453292 A CN109453292 A CN 109453292A CN 201811585080 A CN201811585080 A CN 201811585080A CN 109453292 A CN109453292 A CN 109453292A
- Authority
- CN
- China
- Prior art keywords
- parts
- radix
- alleviation
- auxiliary material
- raw material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7016—Disaccharides, e.g. lactose, lactulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/58—Reptiles
- A61K35/586—Turtles; Tortoises, e.g. terrapins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/51—Gentianaceae (Gentian family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/59—Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/714—Aconitum (monkshood)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/732—Chaenomeles, e.g. flowering quince
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/754—Evodia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8964—Anemarrhena
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Insects & Arthropods (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Husbandry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明提供了一种缓解中风后遗症引起的功能障碍药物,它由如下重量份数的原料提取后与辅料制备得到:原料为:生地15‑20份、桂枝6‑10份、附子7‑11份、牛膝8‑12份、青风藤15‑20份、秦艽8‑12份、木瓜8‑12份、吴茱萸2‑4份、桑椹子20‑40份、知母8‑12份、黄柏4‑8份、丹皮4‑8份、桃仁8‑12份、红花8‑12份、当归10‑20份、甘草2‑4份,辅料为冰糖20‑40份、蜂蜜30‑40份、鳖甲25‑35份,通过养阴生津、温经通脉、补火助阳达到治疗中风后遗症引起的功能障碍目的,并公开了制备方法和用途。
Description
技术领域
本发明涉及中药技术领域,具体涉及一种缓解中风后遗症引起的功能障碍药物及其制备方法和应用。
背景技术
中风是中医内科最严重的病证之一,居长期致残疾病的首位,中风病机复杂,目前医疗条件和设备,无法做到从根本上治愈卒中本身,患者在中风病发时间超过6个月以上仍未痊愈,这一时期多数患者仍存在肢体运动、皮肤感觉、言语表达等功能障碍,严重者会出现共济障碍及认知障碍等,严重影响病人的生活质量。
发明内容
发明目的:为了解决上述问题,本发明的目的在于提供一种缓解中风后遗症引起的功能障碍药物及其制备方法和应用。
技术方案:本发明的目的是通过如下的方案实现的:
一种缓解中风后遗症引起的功能障碍药物,它由如下重量份数的原料提取后与辅料制备得到:原料为:生地15-20份、桂枝6-10份、附子7-11份、牛膝8-12份、青风藤15-20份、秦艽8-12份、木瓜8-12份、吴茱萸2-4份、桑椹子20-40份、知母8-12份、黄柏4-8份、丹皮4-8份、桃仁8-12份、红花8-12份、当归10-20份、甘草2-4份,辅料为冰糖20-40份、蜂蜜30-40份、鳖甲25-35份。
所述的缓解中风后遗症引起的功能障碍药物,它由如下重量份数的原料提取后与辅料制备得到:原料为:生地18份、桂枝8份、附子9份、牛膝10份、青风藤18份、秦艽10份、木瓜10份、吴茱萸3份、桑椹子30份、知母10份、黄柏6份、丹皮6份、桃仁10份、红花10份、当归15份、甘草3份,辅料为冰糖30份、蜂蜜35份、鳖甲30份。
所述的缓解中风后遗症引起的功能障碍药物,所述原料经提取后添加辅料制成膏滋。
所述的缓解中风后遗症引起的功能障碍药物,制备方法包括如下步骤:取药材原料合并,加水煎煮三次,合并煎液,减压浓缩至65℃时相对密度为1.15-1.20的浸膏,添加辅料制成膏滋。
所述的缓解中风后遗症引起的功能障碍药物的制备方法,步骤中,每次加水量为药材重量的10倍量,煎煮2h。
上述缓解中风后遗症引起的功能障碍药物在制备治疗中风后遗症药物中的应用。
有益效果:
本发明组合物从三个方面治疗中风后遗症引起的功能障碍,其一养阴生津、温经通脉、补火助阳,中风后遗症一般患病时间长,日久则津血亏虚,脉络不通,气血不畅,髓海失养,其二中风后遗症一般表现为手足不遂,言语蹇涩,气血逆乱,阳亢风动,瘀血痰浊则是缺血性中风的重要病理因素,使用牛膝、青风藤、秦艽、木瓜引药下行、活血通络、利关节、通经络,又气血化生无源,因虚成瘀,取桃仁、红花、当归活血祛瘀,通过改善血流动力学及微循环、降低毛细血管通透性、加速纤维蛋白溶解、保护脑细胞等方面作用于心,其三中风病多见于中老年人,脏腑功能衰退、气血渐衰为其发病基础,吴茱萸、桑椹子、知母、黄柏、丹皮、鳖甲滋补肝肾、补髓益阴,针对年老中风病人肝肾亏虚。
发明人在临床上形成对中风后遗症引起的功能障碍的总体分析,并根据当前的研究成果加以分析,认为“痰热、瘀血血、气虚、肾亏”的认识,一直备受关注,反复研究并根据临床用药筛选出本处方。
该方中生地、桂枝、附子为君药,能养阴生津、温经通脉、补火助阳,牛膝、青风藤、秦艽、木瓜、桃仁、红花、当归为臣药,行气运血、活血通络化瘀、利关节、通经络,吴茱萸、桑椹子、知母、黄柏、丹皮、鳖甲滋补肝肾为佐药,甘草为使药,全方针对中风后遗症引起的功能障碍,克服瘀血痰浊导致偏身瘫痪的出现。
具体实施方式
以下通过实施例形式,对本发明的上述内容再作进一步的详细说明,但不应将此理解为本发明上述主题的范围仅限于以下的实例,凡基于本发明上述内容所实现的技术均属于本发明的范围。
实施例1:取原料生地15份、桂枝10份、附子7份、牛膝12份、青风藤15份、秦艽12份、木瓜8份、吴茱萸4份、桑椹子20份、知母12份、黄柏4份、丹皮8份、桃仁8份、红花12份、当归10份、甘草4份,辅料为冰糖20份、蜂蜜40份、鳖甲25份,原料合并,加水煎煮三次,每次加水量为药材重量的10倍量,煎煮2h,合并煎液,减压浓缩至65℃时相对密度为1.15的浸膏,添加辅料制成膏滋。
实施例2:取原料生地20份、桂枝6份、附子11份、牛膝8份、青风藤20份、秦艽8份、木瓜12份、吴茱萸2份、桑椹子40份、知母8份、黄柏8份、丹皮4份、桃仁12份、红花8份、当归20份、甘草2份,辅料为冰糖40份、蜂蜜30份、鳖甲35份,原料合并,加水煎煮三次,每次加水量为药材重量的10倍量,煎煮2h,合并煎液,减压浓缩至65℃时相对密度为1.20的浸膏,添加辅料制成膏滋。
实施例3:取原料生地18份、桂枝8份、附子9份、牛膝10份、青风藤18份、秦艽10份、木瓜10份、吴茱萸3份、桑椹子30份、知母10份、黄柏6份、丹皮6份、桃仁10份、红花10份、当归15份、甘草3份,辅料为冰糖30份、蜂蜜35份、鳖甲30份,原料合并,加水煎煮三次,每次加水量为药材重量的10倍量,煎煮2h,合并煎液,减压浓缩至65℃时相对密度为1.18的浸膏,添加辅料制成膏滋。
实施例4:本发明治疗中风后遗症引起的功能障碍的临床研究
4.1在2016年12-2017年12月期间,南京市仙林医院(均有CT或MRI西医诊断支持)根据纳入和排除标准,对符合试验标准的80例中风后遗症患者,治疗组采取西药常规治疗加本发明实施例3制备的膏滋,治疗8周。
4.2诊断标准:
4.2.1以半身不遂,口舌歪斜,舌强言蹇,偏身麻木,甚则神志恍惚、迷蒙、神昏、昏愦为主症。
4.2.2发病急骤,有渐进发展过程。病前多有头晕头痛,肢体麻木等先兆。
4.2.3常有年老体衰,劳倦内伤,嗜好烟酒,膏粱厚味等因素。每因恼怒、劳累、酗酒、感寒等诱发。
4.2.4作血压、神经系统、脑脊液及血常规、眼底等检查。有条件做CT、磁共振检查,可有异常表现。
4.2.5应注意与痫病、厥证、痉病等鉴别。
4.3治疗方法
西医基础治疗:常规予以阿司匹林肠溶片100mg晨服(或硫酸氢氯吡格雷片75mg),阿托伐他汀钙片20mg口服,以及对症处理(调整血压、调整血糖、维持水电解质平衡)等。
治疗组采取实施例3方法制备的膏滋口服,每次20ml,早晚温服,疗程8周。
对照组给予补阳还五汤口服,每次20ml,每日3次,疗程为8周。
4.4疗效评定
①临床治愈:半身不遂及语言蹇涩消除,活动自如者;②显效:语言转清,偏瘫肢体恢复比原来增加N(较前多一级或者一级以上)级肌力以上,能扶拐步行,生活自理者;③好转:症状、体征部分改善,但生活不能自理者;④无效:症状、体征无明显改善。
4.5肌力肌张力①肌力的六级记录法;0级:完全瘫痪,肌肉无收缩;1级:肌肉可收缩,但不能产生动作;2级:肢体全能在床上移动,但不能抵抗自身重力,即不能抬起;3级:肢体能抵抗重力离开床面,但不能抵抗阻力;4级;肢体能抗阻力动作,但不完全;5级:正常肌力;②肌张力分级标准(改良的Ashworth)0级:正常肌张力;1级:肌张力略微增加;受累部分被动屈伸时,在关节活动范围之末时呈现最小的阻力,或出现突然卡住和突然释放;1级:肌张力轻度增加:在关节活动后5%范围内出现突然卡住,然后再关节活动范围后50%呈现最小阻力;2级:肌张力较明显地增加;通过关节活动的大部分时,肌张力较明显地増加,但受累部分仍能较容易地被移动;3级;肌张力严重増加:被动活动困难;4级:僵直:受累部分被动屈伸时呈现僵直状态,不能活动。
4.6治疗前肌力比较
肌力 | 0 | 1 | 2 | 3 | 4 | X±s | P |
治疗组(例数) | 4 | 3 | 4 | 18 | 11 | 2.73±1.24 | |
对照组(例数) | 3 | 4 | 5 | 19 | 9 | 2.68±1.16 | P=0.323 |
经t检验分析可知P>0.05,由此说明在肌力方面治疗组与对照组患者,无统计学差异,有可比性。
4.7肌张力比较
肌张力 | 0 | 1 | 2 | 3 | 4 | X±s | P |
治疗组(例数) | 24 | 3 | 13 | 0 | 0 | 0.73±0.933 | |
对照组(例数) | 22 | 4 | 14 | 0 | 0 | 0.80±0.939 | 0.083 |
经t检验分析可知P>0.05,由此说明在肌张力方面治疗组与对照组患者,无统计学差异,有可比性。
4.8治疗组治疗前后肌力比较
经t检验分析可知P<0.05,由此说明治疗组在治疗后肌力改善,有统计学意义。
4.9治疗组治疗前后肌张力比较
经t检验分析可知P<0.05,由此说明治疗组在治疗后肌张力改善,有统计学意义。
本发明服用后能有效改善肌力和肌张力,表明本发明有治疗中风后遗症引起的功能障碍的作用。
Claims (5)
1.一种缓解中风后遗症引起的功能障碍药物,其特征在于,它由如下重量份数的原料提取后与辅料制备得到:原料为:生地15-20份、桂枝6-10份、附子7-11份、牛膝8-12份、青风藤15-20份、秦艽8-12份、木瓜8-12份、吴茱萸2-4份、桑椹子20-40份、知母8-12份、黄柏4-8份、丹皮4-8份、桃仁8-12份、红花8-12份、当归10-20份、甘草2-4份,辅料为冰糖20-40份、蜂蜜30-40份、鳖甲25-35份。
2.根据权利要求1所述的缓解中风后遗症引起的功能障碍药物,其特征在于,它由如下重量份数的原料提取后与辅料制备得到:原料为:生地18份、桂枝8份、附子9份、牛膝10份、青风藤18份、秦艽10份、木瓜10份、吴茱萸3份、桑椹子30份、知母10份、黄柏6份、丹皮6份、桃仁10份、红花10份、当归15份、甘草3份,辅料为冰糖30份、蜂蜜35份、鳖甲30份。
3.根据权利要求1或2所述的缓解中风后遗症引起的功能障碍药物,其特征在于,所述原料经提取后添加辅料制成膏滋。
4.根据权利要求1或2所述的缓解中风后遗症引起的功能障碍药物,其特征在于,制备方法包括如下步骤:取药材原料合并,加水煎煮三次,合并煎液,减压浓缩至65℃时相对密度为1.15-1.20的浸膏,添加辅料制成膏滋。
5.根据权利要求4所述的缓解中风后遗症引起的功能障碍药物,其特征在于,制备方法步骤中,每次加水量为药材重量的10倍量,煎煮2h。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201811585080.6A CN109453292B (zh) | 2018-12-24 | 2018-12-24 | 一种缓解中风后遗症引起的功能障碍药物 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201811585080.6A CN109453292B (zh) | 2018-12-24 | 2018-12-24 | 一种缓解中风后遗症引起的功能障碍药物 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN109453292A true CN109453292A (zh) | 2019-03-12 |
CN109453292B CN109453292B (zh) | 2021-07-16 |
Family
ID=65615067
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201811585080.6A Active CN109453292B (zh) | 2018-12-24 | 2018-12-24 | 一种缓解中风后遗症引起的功能障碍药物 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN109453292B (zh) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH02255622A (ja) * | 1989-03-28 | 1990-10-16 | Tsumura & Co | 制癌補助剤 |
CN102648961A (zh) * | 2012-04-12 | 2012-08-29 | 李胜利 | 一种治疗缺血性中风后遗症的药物 |
CN102872254A (zh) * | 2012-09-03 | 2013-01-16 | 李承平 | 一组活血逐瘀颗粒 |
CN104623056A (zh) * | 2014-12-28 | 2015-05-20 | 张巧红 | 舒筋活络酒 |
-
2018
- 2018-12-24 CN CN201811585080.6A patent/CN109453292B/zh active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH02255622A (ja) * | 1989-03-28 | 1990-10-16 | Tsumura & Co | 制癌補助剤 |
CN102648961A (zh) * | 2012-04-12 | 2012-08-29 | 李胜利 | 一种治疗缺血性中风后遗症的药物 |
CN102872254A (zh) * | 2012-09-03 | 2013-01-16 | 李承平 | 一组活血逐瘀颗粒 |
CN104623056A (zh) * | 2014-12-28 | 2015-05-20 | 张巧红 | 舒筋活络酒 |
Also Published As
Publication number | Publication date |
---|---|
CN109453292B (zh) | 2021-07-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101264275B (zh) | 一种治疗肩周炎及颈椎病的药枕 | |
CN104147284B (zh) | 一种治疗癫痫的中药制剂及制备方法 | |
CN101559195B (zh) | 治疗癫痫的胶囊 | |
CN101810772B (zh) | 治疗突发性耳聋耳鸣的中药 | |
CN103784573B (zh) | 一种治疗假性近视的中草药配方及其制作方法 | |
CN112190638A (zh) | 一种治疗脑梗死恢复期卒中后失眠的中药组合物及其应用 | |
CN109453292A (zh) | 一种缓解中风后遗症引起的功能障碍药物 | |
CN104547598A (zh) | 一种治疗神经衰弱的中药制剂及制备方法 | |
CN103961560B (zh) | 一种治疗气郁化火证型脑鸣的中药组合物 | |
CN108261506B (zh) | 一种治疗脱发的药物 | |
CN104940673A (zh) | 一种治疗化疗相关周围神经毒性的中药外洗剂及护理方法 | |
CN104740210B (zh) | 一种治疗气滞血瘀型颅脑外伤综合症的中药及制备方法 | |
CN108686094A (zh) | 一种降血糖的中药及其制备方法 | |
CN104055925A (zh) | 一种治疗糖尿病周围神经病变的中药组合物 | |
CN102240357A (zh) | 一种治疗耳鸣的药物及其制备方法 | |
CN101874864A (zh) | 治疗颈性眩晕疾病的中成药物 | |
CN106267104A (zh) | 一种治疗抑郁、失眠及神经衰弱症的汤剂药物及制备方法 | |
CN106491732A (zh) | 治疗神经性头痛的药物组合物及制备方法 | |
CN104887985A (zh) | 治疗行尸综合症的组合中药 | |
CN104784605A (zh) | 一种治疗老年痴呆的中药组合物及其制备方法 | |
CN104840551A (zh) | 一种缓解高血压的桑叶中药制剂及制备方法 | |
CN104784588A (zh) | 一种用于治疗神经性头痛的中药制剂及制备方法 | |
CN105147886A (zh) | 一种治疗紧张性头痛的中药 | |
CN103735827B (zh) | 一种治疗眩晕导致的头目昏花的药酒 | |
CN103301354B (zh) | 一种治疗婴幼儿阴道炎的散剂制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant |