CN109453141A - A kind of preparation method for treating chronic pharyngitis film - Google Patents
A kind of preparation method for treating chronic pharyngitis film Download PDFInfo
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- CN109453141A CN109453141A CN201811410239.0A CN201811410239A CN109453141A CN 109453141 A CN109453141 A CN 109453141A CN 201811410239 A CN201811410239 A CN 201811410239A CN 109453141 A CN109453141 A CN 109453141A
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Abstract
The present invention relates to a kind of for treating the Huang Shi sound oral film of chronic pharyngitis, it is mixed with by the excipient substance that the sterculia seed, campanulaceae, cicada slough, Radix Glycyrrhizae, Fructus Forsythiae, rheum officinale, Rhizoma Chuanxiong, terminalia flesh, fritillaria thunbergii, peppermint, catechu, menthol are prepared into drug extract and prepare film forming agent, wherein the excipient substance includes filmogen, plasticizer, disintegrating agent, colorant, their mass ratio is 1:1-1.5:0.3-0.6:0.06-0.12:0.02-0.05.
Description
Technical field
The present invention relates to traditional Chinese medicine preparation field more particularly to a kind of treat chronic pharyngitis film.
Background technique
Chronic pharyngitis is to swallow mucous membrane, under mucous membrane and the chronic inflammation of lymphoid tissue.Chronic pharyngitis is more common in adult, children
Also it may occur in which.Constitutional symptom is unobvious, based on local symptom.Various chronic pharyngitis symptom is substantially similar and varied,
If pharyngeal discomfort sense, foreign body sensation, pharyngeal secretion are not easy to bring up, pharyngeal gargalesthesia, burn feeling, dry sensation or excitement, can also have
Hypodynia sense.Since pharynx rear wall is usually because of secretion adherency more sticky caused by pharyngeal chronic inflammation, and due to nose, nasal sinus, nasopharynx
Portion's lesion causes night mouth breathing, often occurs irritable cough and nausea when from morning.Since foreign body in pharynx sense can behave as
Frequently swallow.Pharyngeal secretion it is few and be not easy expectoration person often show as habitually dry cough and clear one's throat expectoration movement, if firmly
Pharyngeal mucosa hemorrhage can be caused by coughing or clearing one's throat, and cause band blood in secretion.This disease is common in clinic, and the course of disease is long, symptom
It is easy recurrent exerbation.
" Chinese Pharmacopoeia " version in 2015 discloses Lotrimin Sol Lotrimin, by the sterculia seed, campanulaceae, cicada slough, Radix Glycyrrhizae, Fructus Forsythiae, rheum officinale,
Rhizoma Chuanxiong, terminalia flesh, fritillaria thunbergii, peppermint, catechu, menthol are prepared, have dispelling wind and heat, reducing phlegm and resolving masses, relieving sore-throat open sound it
Effect.Huang Shi sound class medicament, which is mainly pill but also has, currently on the market is prepared into lozenge, medicinal tea.Pill is for children
Dysphagia is also easy to produce with old man patient and is not easy the problems such as taking, lozenge and medicinal tea since the influence of Chinese medicine odor is also not easy to take
With.Therefore need to increase dosage form to meet the needs of different patients.
Drug and the processed manufactured film-like preparation of suitable filmogen include: for oral or mucous membrane, pelliculae pro cavo oris
Orodispersible film, medicine membrane of oral cavity, sublingual film, oral film, oral instant membrane, oral film, the molten film of mouth etc.,
But Chinese medicine prepares the Chinese medicine that film forming agent difficulty is more, especially in extract containing bitter ingredient or fibre composition, preparation
Film forming agent is given to take and make troubles.
Summary of the invention
It is an object of the invention to provide a kind of preparation method of film for Huang Shi sound prescription.
The present invention provides a kind of Huang Shi sound film, the film has the medicinal material in Huang Shi sound prescription by extracting
It is prepared into Huang Shi sound film together to Chinese medical extract, using extract as drug ingedient and filmogen.
Fibre composition to make Huang Shi sound film of the present invention avoid the bitterness in Chinese medical extract and wherein contain causes to take
Medicine is difficult, and the present invention finds a kind of suitable preparation method after study, solves the problems of the prior art.
For this purpose, the present invention provides a kind of Huang Shi sound films, by the sterculia seed, campanulaceae, cicada slough, Radix Glycyrrhizae, Fructus Forsythiae, rheum officinale, river
The Chinese medicines such as rhizome of chuanxiong, terminalia flesh, fritillaria thunbergii, peppermint, catechu, menthol are prepared into active pharmaceutical ingredient, further increase with filmogen
Modeling agent, disintegrating agent, colorant etc. are prepared by mixing into Huang Shi sound film, and wherein filmogen is polyvinyl alcohol (PVA), colorant
For titanium dioxide (TiO2), herbal extract, filmogen, plasticizer, disintegrating agent, colorant mass ratio be 1:1-1.5:
0.3-0.6:0.06-0.12:0.02-0.05.
Wherein, plasticizer is one or more of sorbierite, polyethylene glycol (PEG) and glycerol.
Wherein, disintegrating agent is one or more of sodium carboxymethylcellulose (CMC), pre-paying starch, crospovidone.
Wherein, the preparation method of the active pharmaceutical ingredient, be it is improved, avoid bitter taste and cellulosic
In the presence of, preparation method of the invention the following steps are included:
(1) add suitable quantity of water to decoct secondary, each certain time the 11 taste medicinal materials for removing menthol in Huang Shi sound prescription, close
And decocting liquid, it staticly settles, filters, filtrate is concentrated into right amount；
(2) heating stirring is to being completely dissolved after mixing PVA with water, sequentially adds plasticizer, disintegrating agent, in above-mentioned (1)
Concentrate, colorant, stir evenly and rubber cement solution are made；
(3) it separately takes PVA to be added in alcoholic solvent, menthol is added while stirring, stirs evenly and rubber cement solution is made；
(4) it takes rubber cement the tape casting obtained by step (2) that medicine film layer is made, glue in above-mentioned steps (3) is added on the medicine film layer
Slurry solution continues that medicine film is made using the tape casting, spontaneously dries to obtain the final product；
By obtained medicine film cut, sterilizing to get.
Further, heating temperature is 40 DEG C -60 DEG C in step (1).
Further, in step (2), alcoholic solvent is the ethanol water of 20%-80% mass fraction.
It is currently preferred formula and the preparation method is as follows:
(1) by 5 parts of the sterculia seed, 50 parts of campanulaceae, 20 parts of cicada slough, 50 parts of Radix Glycyrrhizae, 50 parts of Fructus Forsythiae, 20 parts of rheum officinale, 20 parts of Rhizoma Chuanxiong, scold
40 part of 11 20 parts of sub- meat, 60 parts of fritillaria thunbergii, 40 parts of peppermint, catechu taste medicinal material add 6-10 times to measure, and water decoction is secondary, and each 1-2 is small
When, collecting decoction staticly settles, and filtration, filtrate is concentrated into appropriate (relative density 1.35-1.40)；
(2) heating stirring is to being completely dissolved after taking 12-15gPVA to mix with water, sequentially add PEG0.6-1.0g, CMC3-5g, on
State concentrate 8-12g, TIO in (1)20.2-0.5g.Rubber cement solution is uniformly made in magnetic agitation at 40 DEG C -60 DEG C；
(3) it separately takes PVA to be added in alcoholic solvent, menthol is added while stirring, stirs evenly and rubber cement solution is made；
(4) it takes rubber cement the tape casting obtained by step (2) that medicine film layer is made, it is molten that rubber cement in above-mentioned steps (3) is added on the medicine film layer
Liquid continues that medicine film is made using the tape casting, spontaneously dries to obtain the final product；
By obtained medicine film cut, sterilizing to get.
The present invention be most preferably formulated and the preparation method is as follows:
(1) by 5 parts of the sterculia seed, 50 parts of campanulaceae, 20 parts of cicada slough, 50 parts of Radix Glycyrrhizae, 50 parts of Fructus Forsythiae, 20 parts of rheum officinale, 20 parts of Rhizoma Chuanxiong, scold
It is secondary that 40 part of 11 20 parts of sub- meat, 60 parts of fritillaria thunbergii, 40 parts of peppermint, catechu taste medicinal material add 6 times of amount water to decoct, and 1.5 hours every time, closes
And decocting liquid, it staticly settles, filters, filtrate is concentrated into appropriate (relative density 1.35-1.40)；
(2) heating stirring is to being completely dissolved after taking 15gPVA to mix with water, sequentially adds PEG0.8g, CMC5g, dense in above-mentioned (1)
Contracting liquid 10g, TIO20.3g.Rubber cement solution is uniformly made in magnetic agitation at 60 DEG C；
(3) it separately takes PVA to be added in alcoholic solvent, menthol is added while stirring, stirs evenly and rubber cement solution is made；
(4) it takes rubber cement the tape casting obtained by step (2) that medicine film layer is made, it is molten that rubber cement in above-mentioned steps (3) is added on the medicine film layer
Liquid continues that medicine film is made using the tape casting, spontaneously dries to obtain the final product；
By obtained medicine film cut, sterilizing to get.
Formula and preparation method of the invention is obtained by screening, and screening process is as follows:
The preparation of active pharmaceutical ingredient is screened:
6 times of amount water are added to decoct 11 taste medicinal materials in Huang Shi sound prescription in addition to menthol secondary, 1 hour every time, collecting decoction,
It staticly settles, filters, filtrate is concentrated into appropriate (relative density 1.35-1.40), and concentrate is active constituent 1；
Add 8 times of amount water to decoct 11 taste medicinal materials in Huang Shi sound prescription in addition to menthol secondary, 1.5 hours every time, merges and decoct
Liquid staticly settles, and filtration, filtrate is concentrated into appropriate (relative density 1.35-1.40), and concentrate is active constituent 2；
Add 10 times of amount water to decoct 11 taste medicinal materials in Huang Shi sound prescription in addition to menthol secondary, 2 hours every time, merges and decoct
Liquid staticly settles, and filtration, filtrate is concentrated into appropriate (relative density 1.35-1.40), and concentrate is active constituent 3；
Add 6 times of amount water to decoct 11 taste medicinal materials in Huang Shi sound prescription in addition to menthol secondary, 1.5 hours every time, merges and decoct
Liquid staticly settles, and filtration, filtrate is concentrated into appropriate (relative density 1.35-1.40), and concentrate is active constituent 4；
The assay that above-mentioned concentrate is carried out to peimine and Peininine, determines the preparation method of active pharmaceutical ingredient,
Assay the results are shown in Table 1.
The screening of filmogen:
Filmogen being dissolved in the ethyl alcohol of certain mass score, magnetic agitation dissolves under certain temperature, solution left standstill is deaerated,
According to certain specification film on substrate, dry, cooling, demoulding carries out disintegration time test, and test result is shown in Table 2.
The screening of plasticizer:
Filmogen is dissolved in the ethyl alcohol of certain mass score, magnetic agitation dissolves under certain temperature, in the molten of stirring and dissolving
Plasticizer is added in liquid, continues magnetic agitation dissolution, stands degassing, according to certain specification film on substrate, drying is cold
But, demoulding, carries out disintegration time and elasticity modulus test, and test result is shown in Table 3.
The screening of disintegrating agent:
Filmogen is dissolved in the ethyl alcohol of certain mass score, magnetic agitation dissolves under certain temperature, in the molten of stirring and dissolving
Plasticizer is added in liquid, continues magnetic agitation dissolution, adds disintegrating agent, continues magnetic agitation dissolution, stands de-
Gas, according to certain specification film on substrate, dry, cooling, demoulding carries out disintegration time test, and test result is shown in Table 4.
The screening of colorant:
Since effective component extracts color is deeper in the prescription, and TIO2Covering power is high, stablizes, good weatherability, therefore preferably
For the colorant of this preparation.
The invention has the beneficial effects that:
Menthol in the present invention is placed on except remaining Chinese medicine film layer, can cover the bad smell of Chinese medical extract, and
Have peppermint fragrance, improve mouthfeel, can increase patient medication comfort, and Chinese medical extract be all add water to cook and
At therefore drug ingedient is all water soluble ingredient, into can quickly dissolve in patient mouthful.
Film of the invention takes simplicity, is especially suitable for children and the elderly takes, and dissolves out and absorb very fast.
Preparation method simple process of the invention, is conducive to large-scale industrial production.
Specific embodiment
Embodiment 1
(1) by 5 parts of the sterculia seed, 50 parts of campanulaceae, 20 parts of cicada slough, 50 parts of Radix Glycyrrhizae, 50 parts of Fructus Forsythiae, 20 parts of rheum officinale, 20 parts of Rhizoma Chuanxiong,
It is secondary that 40 part of 11 20 parts of terminalia flesh, 60 parts of fritillaria thunbergii, 40 parts of peppermint, catechu taste medicinal material add 6 times of amount water to decoct, and 1.5 hours every time,
Collecting decoction staticly settles, and filtration, filtrate is concentrated into appropriate (relative density 1.35-1.40)；
(2) heating stirring is to being completely dissolved after taking 12gPVA to mix with water, sequentially adds sorbierite 0.6g, CMC4g, above-mentioned
(1) concentrate 10g, TIO in20.3g.Rubber cement solution is uniformly made in magnetic agitation at 60 DEG C；
(3) it separately takes PVA to be added in alcoholic solvent, menthol is added while stirring, stirs evenly and rubber cement solution is made；
(4) it takes rubber cement the tape casting obtained by step (2) that medicine film layer is made, glue in above-mentioned steps (3) is added on the medicine film layer
Slurry solution continues that medicine film is made using the tape casting, spontaneously dries to obtain the final product；
By obtained medicine film cut, sterilizing to get.
Embodiment 2
(1) by 5 parts of the sterculia seed, 50 parts of campanulaceae, 20 parts of cicada slough, 50 parts of Radix Glycyrrhizae, 50 parts of Fructus Forsythiae, 20 parts of rheum officinale, 20 parts of Rhizoma Chuanxiong,
It is secondary that 40 part of 11 20 parts of terminalia flesh, 60 parts of fritillaria thunbergii, 40 parts of peppermint, catechu taste medicinal material add 6 times of amount water to decoct, and 1.5 hours every time,
Collecting decoction staticly settles, and filtration, filtrate is concentrated into appropriate (relative density 1.35-1.40)；
(2) heating stirring is to being completely dissolved after taking 13gPVA to mix with water, sequentially add PEG0.8g, pre-paying starch 5g,
Concentrate 10g, TIO in above-mentioned (1)20.4g.Rubber cement solution is uniformly made in magnetic agitation at 60 DEG C；
(3) it separately takes PVA to be added in alcoholic solvent, menthol is added while stirring, stirs evenly and rubber cement solution is made；
(4) it takes rubber cement the tape casting obtained by step (2) that medicine film layer is made, glue in above-mentioned steps (3) is added on the medicine film layer
Slurry solution continues that medicine film is made using the tape casting, spontaneously dries to obtain the final product；
By obtained medicine film cut, sterilizing to get.
Embodiment 3
(1) by 5 parts of the sterculia seed, 50 parts of campanulaceae, 20 parts of cicada slough, 50 parts of Radix Glycyrrhizae, 50 parts of Fructus Forsythiae, 20 parts of rheum officinale, 20 parts of Rhizoma Chuanxiong,
It is secondary that 40 part of 11 20 parts of terminalia flesh, 60 parts of fritillaria thunbergii, 40 parts of peppermint, catechu taste medicinal material add 6 times of amount water to decoct, and 1.5 hours every time,
Collecting decoction staticly settles, and filtration, filtrate is concentrated into appropriate (relative density 1.35-1.40)；
(2) heating stirring sequentially adds glycerol 1.0g, crospovidone to being completely dissolved after taking 14gPVA to mix with water
Concentrate 10g, TIO in 6g, above-mentioned (1)20.2g.Rubber cement solution is uniformly made in magnetic agitation at 60 DEG C；
(3) it separately takes PVA to be added in alcoholic solvent, menthol is added while stirring, stirs evenly and rubber cement solution is made；
(4) it takes rubber cement the tape casting obtained by step (2) that medicine film layer is made, glue in above-mentioned steps (3) is added on the medicine film layer
Slurry solution continues that medicine film is made using the tape casting, spontaneously dries to obtain the final product；
By obtained medicine film cut, sterilizing to get.
Embodiment 4
(1) by 5 parts of the sterculia seed, 50 parts of campanulaceae, 20 parts of cicada slough, 50 parts of Radix Glycyrrhizae, 50 parts of Fructus Forsythiae, 20 parts of rheum officinale, 20 parts of Rhizoma Chuanxiong,
It is secondary that 40 part of 11 20 parts of terminalia flesh, 60 parts of fritillaria thunbergii, 40 parts of peppermint, catechu taste medicinal material add 6 times of amount water to decoct, and 1.5 hours every time,
Collecting decoction staticly settles, and filtration, filtrate is concentrated into appropriate (relative density 1.35-1.40)；
(2) heating stirring sequentially adds PEG0.7g, CMC3g, above-mentioned (1) to being completely dissolved after taking 15gPVA to mix with water
Middle concentrate 10g, TIO20.5g.Rubber cement solution is uniformly made in magnetic agitation at 60 DEG C；
(3) it separately takes PVA to be added in alcoholic solvent, menthol is added while stirring, stirs evenly and rubber cement solution is made；
(4) it takes rubber cement the tape casting obtained by step (2) that medicine film layer is made, glue in above-mentioned steps (3) is added on the medicine film layer
Slurry solution continues that medicine film is made using the tape casting, spontaneously dries to obtain the final product；
By obtained medicine film cut, sterilizing to get.
Embodiment 5
(1) by 5 parts of the sterculia seed, 50 parts of campanulaceae, 20 parts of cicada slough, 50 parts of Radix Glycyrrhizae, 50 parts of Fructus Forsythiae, 20 parts of rheum officinale, 20 parts of Rhizoma Chuanxiong,
It is secondary that 40 part of 11 20 parts of terminalia flesh, 60 parts of fritillaria thunbergii, 40 parts of peppermint, catechu taste medicinal material add 6 times of amount water to decoct, and 1.5 hours every time,
Collecting decoction staticly settles, and filtration, filtrate is concentrated into appropriate (relative density 1.35-1.40)；
(2) heating stirring sequentially adds sorbierite 0.9g, pre-paying starch to being completely dissolved after taking 12gPVA to mix with water
Concentrate 10g, TIO in 4g, above-mentioned (1)20.3g.Rubber cement solution is uniformly made in magnetic agitation at 60 DEG C；
(3) it separately takes PVA to be added in alcoholic solvent, menthol is added while stirring, stirs evenly and rubber cement solution is made；
(4) it takes rubber cement the tape casting obtained by step (2) that medicine film layer is made, glue in above-mentioned steps (3) is added on the medicine film layer
Slurry solution continues that medicine film is made using the tape casting, spontaneously dries to obtain the final product；
By obtained medicine film cut, sterilizing to get.
Embodiment 6
(1) by 5 parts of the sterculia seed, 50 parts of campanulaceae, 20 parts of cicada slough, 50 parts of Radix Glycyrrhizae, 50 parts of Fructus Forsythiae, 20 parts of rheum officinale, 20 parts of Rhizoma Chuanxiong,
It is secondary that 40 part of 11 20 parts of terminalia flesh, 60 parts of fritillaria thunbergii, 40 parts of peppermint, catechu taste medicinal material add 6 times of amount water to decoct, and 1.5 hours every time,
Collecting decoction staticly settles, and filtration, filtrate is concentrated into appropriate (relative density 1.35-1.40)；
(2) heating stirring sequentially adds glycerol 1.1g, crospovidone to being completely dissolved after taking 14gPVA to mix with water
Concentrate 10g, TIO in 5g, above-mentioned (1)20.4g.Rubber cement solution is uniformly made in magnetic agitation at 60 DEG C；
(3) it separately takes PVA to be added in alcoholic solvent, menthol is added while stirring, stirs evenly and rubber cement solution is made；
(4) it takes rubber cement the tape casting obtained by step (2) that medicine film layer is made, glue in above-mentioned steps (3) is added on the medicine film layer
Slurry solution continues that medicine film is made using the tape casting, spontaneously dries to obtain the final product；
By obtained medicine film cut, sterilizing to get.
Embodiment 7
(1) by 5 parts of the sterculia seed, 50 parts of campanulaceae, 20 parts of cicada slough, 50 parts of Radix Glycyrrhizae, 50 parts of Fructus Forsythiae, 20 parts of rheum officinale, 20 parts of Rhizoma Chuanxiong,
It is secondary that 40 part of 11 20 parts of terminalia flesh, 60 parts of fritillaria thunbergii, 40 parts of peppermint, catechu taste medicinal material add 6 times of amount water to decoct, and 1.5 hours every time,
Collecting decoction staticly settles, and filtration, filtrate is concentrated into appropriate (relative density 1.35-1.40)；
(2) heating stirring sequentially adds PEG0.8g, CMC5g, above-mentioned (1) to being completely dissolved after taking 15gPVA to mix with water
Middle concentrate 10g, TIO20.3g.Rubber cement solution is uniformly made in magnetic agitation at 60 DEG C；
(3) it separately takes PVA to be added in alcoholic solvent, menthol is added while stirring, stirs evenly and rubber cement solution is made；
(4) it takes rubber cement the tape casting obtained by step (2) that medicine film layer is made, glue in above-mentioned steps (3) is added on the medicine film layer
Slurry solution continues that medicine film is made using the tape casting, spontaneously dries to obtain the final product；
By obtained medicine film cut, sterilizing to get.
Embodiment 8
(1) by 5 parts of the sterculia seed, 50 parts of campanulaceae, 20 parts of cicada slough, 50 parts of Radix Glycyrrhizae, 50 parts of Fructus Forsythiae, 20 parts of rheum officinale, 20 parts of Rhizoma Chuanxiong,
It is secondary that 40 part of 11 20 parts of terminalia flesh, 60 parts of fritillaria thunbergii, 40 parts of peppermint, catechu taste medicinal material add 6 times of amount water to decoct, and 1.5 hours every time,
Collecting decoction staticly settles, and filtration, filtrate is concentrated into appropriate (relative density 1.35-1.40)；
(2) heating stirring sequentially adds PEG0.8g, CMC5g, above-mentioned (1) to being completely dissolved after taking 15gPVA to mix with water
Middle concentrate 10g, TIO20.3g.Rubber cement solution is uniformly made in magnetic agitation at 50 DEG C；
(3) it separately takes PVA to be added in alcoholic solvent, menthol is added while stirring, stirs evenly and rubber cement solution is made；
(4) it takes rubber cement the tape casting obtained by step (2) that medicine film layer is made, glue in above-mentioned steps (3) is added on the medicine film layer
Slurry solution continues that medicine film is made using the tape casting, spontaneously dries to obtain the final product；
By obtained medicine film cut, sterilizing to get.
Embodiment 9
(1) by 5 parts of the sterculia seed, 50 parts of campanulaceae, 20 parts of cicada slough, 50 parts of Radix Glycyrrhizae, 50 parts of Fructus Forsythiae, 20 parts of rheum officinale, 20 parts of Rhizoma Chuanxiong,
It is secondary that 40 part of 11 20 parts of terminalia flesh, 60 parts of fritillaria thunbergii, 40 parts of peppermint, catechu taste medicinal material add 6 times of amount water to decoct, and 1.5 hours every time,
Collecting decoction staticly settles, and filtration, filtrate is concentrated into appropriate (relative density 1.35-1.40)；
(2) heating stirring sequentially adds PEG0.8g, CMC5g, above-mentioned (1) to being completely dissolved after taking 15gPVA to mix with water
Middle concentrate 10g, TIO20.3g.Rubber cement solution is uniformly made in magnetic agitation at 40 DEG C；
(3) it separately takes PVA to be added in alcoholic solvent, menthol is added while stirring, stirs evenly and rubber cement solution is made；
(4) it takes rubber cement the tape casting obtained by step (2) that medicine film layer is made, glue in above-mentioned steps (3) is added on the medicine film layer
Slurry solution continues that medicine film is made using the tape casting, spontaneously dries to obtain the final product；
By obtained medicine film cut, sterilizing to get.
Reference examples
It is treated using Lotrimin Sol Lotrimin.
Blank group
Any method is not used to treat
Beneficial effects of the present invention are further illustrated below by test:
Test method: each embodiment select respectively 7-50 years old patients with chronic pharyngitis 30 tested, men and women is fifty-fifty, takes
Huang Shi sound film (area 1.0cm obtained by embodiment 1-92), reference examples Lotrimin Sol Lotrimin, daily in the morning, afternoon and evening respectively use one
Secondary, film uses 2 every time.Blank group does not take any drug.
Test is checked after 7 days, is counted effective, is improved, invalid sufferer number, calculates its total effective rate.Efficacy determination
Standard: 1. effective: without obvious pharyngitis symptom, to feel pharyngeal comfortable；2. improving: still having pharyngitis symptom, but than being delayed before medication
Solution；3. invalid: symptom is not improved.
Test result is shown in Table 5.
Table 1: the result of active constituent difference preparation method
Table 2: the disintegration time limited result of the filmogen of different quality containing
| PVA mass (g) | 12 | 13 | 14 | 15 |
| Disintegration time limited (sec) | 36 | 38 | 39 | 39 |
Table 3: different plasticizer disintegration time limiteds and elasticity modulus result
| Plasticizer | Sorbierite | PEG | Glycerol |
| Disintegration time limited (sec) | 46 | 43 | 45 |
| Elasticity modulus (MPa) | 36 | 40 | 35 |
Table 4: the disintegration time limited result of different disintegrating agents
| Disintegrating agent | Pre-paying starch | Crospovidone | CMC |
| Disintegration time limited (sec) | 38 | 35 | 30 |
Table 5: clinical comparison test result of the sample to chronic pharyngitis
| Patient's (example) | It is effective | It improves | In vain | Total effective rate | |
| Embodiment 1 | 30 | 22 | 7 | 1 | 96.7% |
| Embodiment 2 | 30 | 23 | 6 | 1 | 96.7% |
| Embodiment 3 | 30 | 21 | 8 | 1 | 96.7% |
| Embodiment 4 | 30 | 24 | 5 | 1 | 96.7% |
| Embodiment 5 | 30 | 22 | 7 | 1 | 96.7% |
| Embodiment 6 | 30 | 21 | 8 | 1 | 96.7% |
| Embodiment 7 | 30 | 26 | 4 | 0 | 100% |
| Embodiment 8 | 30 | 25 | 5 | 0 | 100% |
| Embodiment 9 | 30 | 24 | 6 | 0 | 100% |
| Control group | 30 | 25 | 5 | 1 | 96.7% |
| Blank group | 30 | 0 | 0 | 30 | 0% |
By the test result of embodiment 1-9 it is found that Huang Shi sound film of the invention is non-to the therapeutic effect of chronic pharyngitis
Chang Xianzhu.
Above-described embodiment is the preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto, this technology
The several improvements and modifications that the technical staff in field carries out according to the technique and scheme of the present invention also should be regarded as protection model of the invention
It encloses.
Claims (6)
1. a kind of preparation method for treating chronic pharyngitis film, which comprises the following steps:
(1) add 6 times of amount water decoctions secondary Huang Shi sound prescription Chinese medicinal materials, 1.5 hours every time, collecting decoction staticly settled, filter
It crosses, filtrate is concentrated into right amount；
(2) heating stirring is to being completely dissolved after taking filmogen to mix with water, sequentially adds plasticizer, disintegrating agent and above-mentioned (1)
Middle concentrate, colorant.It stirs evenly and rubber cement solution is made；
(3) it separately takes PVA to be added in alcoholic solvent, menthol is added while stirring, stirs evenly and rubber cement solution is made；
(4) it takes rubber cement the tape casting obtained by step (2) that medicine film layer is made, it is molten that rubber cement in above-mentioned steps (3) is added on the medicine film layer
Liquid continues that medicine film is made using the tape casting, spontaneously dries to obtain the final product；
(5) by obtained medicine film cut, sterilizing to get.
2. the preparation method for the treatment of chronic pharyngitis film as described in claim 1, it is characterised in that: herbal extract, film forming
Material, plasticizer, disintegrating agent, colorant mass ratio be 1:1-1.5:0.3-0.6:0.06-0.12:0.02-0.05.
3. as described in claim 1 treatment chronic pharyngitis film preparation method, it is characterised in that: plasticizer be sorbierite,
One or more of polyethylene glycol (PEG) and glycerol.
4. the preparation method for the treatment of chronic pharyngitis film as described in claim 1, it is characterised in that: disintegrating agent is that carboxymethyl is fine
Tie up one or more of plain sodium (CMC), pre-paying starch, crospovidone.
5. the preparation method for the treatment of chronic pharyngitis film as described in claim 1, it is characterised in that: alcoholic solvent 20%-
The ethanol water of 80% mass fraction.
6. the preparation method for the treatment of chronic pharyngitis film as described in claim 1, it is characterised in that: the heating in step (1)
Temperature is 40 DEG C -60 DEG C.
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