CN106236807A - Preventing and treating influenza virus composition and Chinese medicine compound oral instant film preparation - Google Patents
Preventing and treating influenza virus composition and Chinese medicine compound oral instant film preparation Download PDFInfo
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- CN106236807A CN106236807A CN201610572981.6A CN201610572981A CN106236807A CN 106236807 A CN106236807 A CN 106236807A CN 201610572981 A CN201610572981 A CN 201610572981A CN 106236807 A CN106236807 A CN 106236807A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
Abstract
The present invention open one preventing and treating influenza virus composition and Chinese medicine compound oral instant film preparation and preparation method thereof.It is (0.1 0.5) that the present invention prevents and treats the weight ratio that influenza virus composition comprises effective dose: the Dendranthema indicum extract of (1 10) and menthol.Chinese medicine compound oral instant film preparation of the present invention includes the component of following percentage composition: glucomannoglycan 0.5% 2.0%, softening agent 0.5% 3.0%, menthol 0.1% 0.5%, Dendranthema indicum extract 1% 10%, water 85% 97.9%.The present invention prevents and treats influenza virus composition and has obvious resisiting influenza virus effect.Chinese medicine compound oral instant film preparation of the present invention has good casting film-forming, toughness, medicine releasability, and safety non-toxic.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of preventing and treating influenza virus composition and Chinese medicine compound oral cavity speed
Molten film preparation and preparation method thereof.
Background technology
Influenza virus such as H1N1 circulation way: the propagation of influenza virus is mainly air borne, and secondary is that contact passes
Broadcast.Air borne refers to that the people infected by influenza virus such as H1N1 will be with influenza virus such as H1N1 when cough or sneeze
Fine saliva (particle diameter be less than 10 microns) be discharged in air, this slight band poison aerosol-type granule is the most floating,
Will be infected if having sucked this microgranule.
Currently the medicine of infected by influenza is Western medicine mostly, although Western medicine has instant effect feature, but easily produces
Drug resistance.Currently also there is employing treatment by Chinese herbs influenza infection, but existing Chinese medicine exists compatibility complexity, high the asking of cost
Topic.
It addition, by infected by influenza intrusion feature and the research of mode, learn that influenza virus such as H1N1 enters nose or pharynx
Rear division duplication in the goblet cell of the soft palate mucosal epithelium of oral cavity upper part rapidly, then with the apocrine secretion of goblet cell
Form is discharged at oral cavity or nasopharynx, is excreted when cough or sneeze, thus permissible for this situation of influenza virus
Using oral quick-dissolving film preparation to come exactly, directly kill influenza virus such as H1N1, this is more convenient, fast than oral administration solid medicine
And compliance is more preferable.
Oral instant membrane (Oral fast dissolving films is called for short OFDF) refers to that use can be molten in saliva of buccal cavity
A kind of medicine carrying release thin film solved, is the new-type form of administration of one of drug delivery system.OFDF is typically by film former (water solublity
Polymer, content: 40-50%), softening agent (0-20%), pigment spice, filler (0-40%) composition, be characterized in: directly
Acting on pathogen or lesions position, medicine is directly avoided " first pass effect " by mucosal absorption, is not required to water and send children's or sleeping
Bed old man avoids the danger coughed of choking.Without freezing in easy to carry, production technology, OFDF originates from the 70-80 age in last century
Masking technique mature and reliable.There were nearly 80 kinds listing, mainly Novartis and InnoZen public from 2003 in North America
Department produce multiple treatment flu OFDF, 2007 annual value of production 500000000 dollars, within 2012, reach 2,000,000,000 dollars, it is contemplated that 2015 up to
13000000000 dollars.
Currently, OFDF makes has solvent casting method, hot melt extruded method, semi-solid casting method, solid to disperse squeezing and pressing method, roll
, all there are some problems such as in methods etc., but whether which kind of method: energy consumption is high, the physicochemical property of film is difficult to standardization, film former is complete
It is chemical substance, also needs to add softening agent, filler etc..In terms of medicine, the overwhelming majority is chemical synthetic drug.Exist dangerous
The problem that cause drug effect undesirable the best with film forming weight.
Summary of the invention
It is an object of the invention to overcome the above-mentioned deficiency of prior art, it is provided that a kind of preventing and treating influenza virus composition, with
The drug resistance solving to exceed the time limit to take preventing and treating influenza virus Western medicine and cause and the compatibility of Chinese medicinal formulae are complicated, and the technology that cost is high is asked
Topic.
Another object of the present invention is to provide a kind of Chinese medicine compound oral instant film preparation and preparation method thereof, to solve
There is the dangerous and the best technical problem causing drug effect undesirable of film forming weight in existing oral instant membrane.
In order to realize foregoing invention purpose, an aspect of of the present present invention, it is provided that a kind of preventing and treating influenza virus composition.Described
Preventing and treating influenza virus composition comprises Dendranthema indicum extract and the menthol of effective dose；Wherein, described Dendranthema indicum extract
It is (0.1-0.5) with the weight ratio of menthol: (1-10).
Another aspect of the present invention, it is provided that a kind of Chinese medicine compound oral instant film preparation.Described Chinese medicine compound oral cavity speed
Molten film preparation contains the present invention and prevents and treats influenza virus composition, possibly together with glucomannoglycan and softening agent and water, with described Chinese medicine
Compound oral dissolving films total formulation weight amount is 100% meter, described Dendranthema indicum extract, menthol glucomannoglycan and softening agent with
And each component percentages of water is as follows:
Another aspect of the present invention, the preparation method of a kind of Chinese medicine compound oral instant film preparation.Described preparation method bag
Include following steps:
Each component raw material is weighed respectively according to component contained by Chinese medicine compound oral instant film preparation of the present invention；
The Dendranthema indicum extract weighed, menthol glucomannoglycan and softening agent are added in water component and carries out at mixing
Reason.
Compared with prior art, the present invention prevents and treats the influenza virus composition extract with the Dendranthema indicum of effective dose as merit
Energy composition, after itself and menthol are carried out compatibility, both can play the potentiation of administration, so that the embodiment of the present invention
Preventing and treating influenza virus composition has obvious resisiting influenza virus effect, as having obvious antivirus action to H1N1.
It is effective efficiency group that Chinese medicine compound oral instant film preparation of the present invention uses the present invention to prevent and treat influenza virus composition
Point, therefore there is obvious resisiting influenza virus effect.Use glucomannoglycan as film former, and at the synergistic effect of softening agent
Under, giving the casting film-forming performance that Chinese medicine compound oral instant film preparation is good, film forming is open and flat smooth, soft and tool toughness, peace
Atoxic, and the present invention can be made to prevent and treat influenza virus composition and film former blending, the present invention prevents and treats influenza virus combination
Thing release is good.
Each function ingredients is dissolved in water component by the preparation method of Chinese medicine compound oral instant film preparation of the present invention, thus
Ensure that stability and the efficacy stability performance of Chinese medicine compound oral instant membrane preparation system, safety non-toxic, weight is controlled, cost
Low, commercial viability is good.
Detailed description of the invention
In order to make the purpose of the present invention, technical scheme and advantage clearer, below in conjunction with embodiment, to the present invention
It is further elaborated.Should be appreciated that specific embodiment described herein, only in order to explain the present invention, is not used to
Limit the present invention.
The weight of each component that the embodiment of the present invention is noted in the disclosure not only may refer to the ratio of each component and closes
System, it is also possible to represent each group of concrete content, therefore, as long as according to the content of the embodiment of the present invention each component of description compositions
Scale up or reduce all within embodiment of the present invention description scope of disclosure.Specifically, embodiment of the present invention explanation
Weight described in book can be unit of weight known to the field of medicaments such as μ g, mg, g, kg.
On the one hand, a kind of preventing and treating influenza virus composition is embodiments provided.In one embodiment, described preventing and treating
Influenza virus composition comprises Dendranthema indicum extract and the menthol of effective dose.
Wherein, described Dendranthema indicum was found in nineteen eighty-two, was then accredited as new varieties of feverfew, this kind of Flos Chrysanthemi
By Herba Dendranthematis indici mutation, it not only has the pharmacological action of Herba Dendranthematis indici, also has the characteristic of its uniqueness, as flower, leaf, stem, root have pole entirely
Strong fragrance.It has been investigated that, the extract of the Dendranthema indicum of effective dose has antivirus action, it is carried out with menthol
After compatibility, both can play the potentiation of administration, so that embodiment of the present invention preventing and treating influenza virus composition has
Significantly antivirus action, to as described in influenza virus concrete such as A type H1N1There is obvious antivirus action.
In one embodiment, the extract of Dendranthema indicum is to extract according to following extraction conditions to obtain:
Use Dendranthema indicum to be dried stem and/or leaf is raw material, described raw material is carried out reflux, extract, process；Described backflow carries
The temperature taking process is 60-80 DEG C, pressure 0.6-0.8 atmospheric pressure, reflux, extract, 1-2 hour, and the solvent that reflux, extract, processes is
Water.In a particular embodiment, the temperature that described reflux, extract, processes is 80 DEG C, pressure 0.8 atmospheric pressure, reflux, extract, 1 hour, returns
The solvent of stream extraction process is water.
In a particular embodiment, the method that this reflux, extract, processes is as follows:
1. Dendranthema indicum is dried after stem and leaf is cleaned and is dried (if controlling water content≤12%) again；
2. dry stem and leaf was pulverized 30 mesh sieves；
3. (reflux, extract, temperature is 60-80 DEG C to reflux, extract, pressure 0.6-0.8 atmospheric pressure, and reflux, extract, 1-2 hour is excellent
80 DEG C of pressure 0.8 atmospheric pressure of temperature that the described reflux, extract, of choosing processes, soak 30 minutes, reflux, extract, 1 hour；Wherein, return
Stream Extraction solvent is water, and solid-liquid ratio that is to say that raw material and water volume ratio are 1:(10-30), concrete for 1:20)；
4. filtration treatment collects filtrate (processing as used) by three layers of filtered through gauze；
5. recovered liquid vacuum drying (as being dried to crude drug ratio as 1:1 or 1:1.2).
By the control of extracting factor raw-material to Dendranthema indicum, to realize the extract drug effect to Dendranthema indicum
Composition and the control of content, the resisiting influenza virus the most anti-A type good to give embodiment of the present invention preventing and treating influenza virus composition
H1N1 clinical effect.
In order to effectively extract the resisiting influenza virus composition contained by Dendranthema indicum, in a further embodiment, at flooding
During reason, controlling described raw material with water ratio is 1:20.
It addition, on the basis of the various embodiments described above, the effective dose of Dendranthema indicum extract refers to be enough to show individuality
The present invention of benefit or clinical meaning prevents and treats the amount of influenza virus composition.It will be understood to those of skill in the art that the reality of administration
Border amount or dosage and administration time-histories will depend upon which character and seriousness, the age of treated experimenter of treated disease
With general status and administering mode etc..
The existence of described menthol plays that penetrating agent is refrigerant, antiinflammatory, the effect of pain relieving, it is possible to functional component Dendranthema indicum
Extract plays synergistic effect, improves the clinical effect of Dendranthema indicum extract resisiting influenza virus.Simultaneously as menthol is specific
Taste, also act as flavoring agent effect.
In one embodiment, the weight ratio controlling described Dendranthema indicum extract and menthol is (0.1-0.5): (1-
10).Both part by weight are controlled in this scope so that both play synergistic effect, improve Dendranthema indicum extract anti-current
The clinical effect of Influenza Virus.
Therefore, embodiment of the present invention preventing and treating influenza virus composition becomes with the extract of the Dendranthema indicum of effective dose for function
Point, itself and menthol are carried out compatibility, both can play the potentiation of administration, so that embodiment of the present invention preventing and treating stream
Influenza Virus compositions has obvious resisiting influenza virus effect, uses safety, and does not produce drug resistance.
On the basis of the various embodiments described above, embodiment of the present invention preventing and treating influenza virus composition can also contain medicine can
Accept adjuvant, this pharmaceutically acceptable adjuvant refer to well known by persons skilled in the art be suitable for specific mode of administration appoint
What adjuvant.As in a particular embodiment, this pharmaceutically acceptable adjuvant can include can be with function ingredients Dendranthema indicum extract
With one or more pharmaceutically acceptable carriers of menthol compatibility, solvent, excipient, buffer agent, stabilizer, adjuvant, front
Medicine and treatment can benefit from or strengthen the other therapeutic agents of above-mentioned preventing and treating influenza virus composition.It should be appreciated that it is above-mentioned
Each adjuvant should be nontoxic, do not disturb or do not damage the embodiment of the present invention preventing and treating function of influenza virus composition and effect.
It addition, can select flexibly according to the existence dosage form of above-described embodiment preventing and treating influenza virus composition selected by this adjuvant.As
In one embodiment, film former selected by this adjuvant.
Therefore, on the other hand, the embodiment of the present invention additionally provides a kind of Chinese medicine compound oral instant film preparation.Implement one
In example, described Chinese medicine compound oral instant film preparation contains preventing and treating influenza virus composition mentioned above, sweet poly-possibly together with Portugal
Sugar and the component such as softening agent and water.Being in terms of 100% by described Chinese medicine compound oral instant membrane total formulation weight amount, the described legendary god of farming is fragrant
Chrysanthemum extract, menthol glucomannoglycan and softening agent and each component percentages of water are as follows:
Wherein, the glucomannoglycan contained by Chinese medicine compound oral instant film preparation has water solublity, sol-gel, film property
And the feature such as rheological characteristic, therefore, in embodiments of the present invention, glucomannoglycan is as film former.It has been investigated that, real in the present invention
Execute in example, its weight fraction can be become when 0.5%-2.0% collosol state, colloidal sol after curtain coating can in 30 minutes film forming.
Preferably glucomannan requires purity more than 90%, to ensure quality of forming film.It addition, glucomannan itself is that a kind of meals are fine
Tieing up, it can resolve into the favourable probiotic bacteria of short-chain fatty acid in intestinal and promote enterokinesia after being absorbed by the body, therefore Portugal's glycosides gathers
Sugar is good film former, and therefore, it uses safety.
Above-mentioned softening agent can assist in glucomannoglycan film forming, improves Chinese medicine compound oral instant film preparation quality of forming film, composes
Give the casting film-forming performance that Chinese medicine compound oral instant film preparation is good so that film forming is open and flat smooth, soft and toughness, safe nothing
Poison, and preventing and treating influenza virus composition and film former blending can be made so that preventing and treating influenza virus composition such as Dendranthema indicum
Extract and menthol release are good.
In one embodiment, at least one during described softening agent selects lecithin, glycerol, sorbitol.By to softness
The selection of agent, it is possible to make to play between softening agent and glucomannoglycan the potentiation of film forming, it is provided that quality of forming film and raising are anti-
Control influenza virus composition such as Dendranthema indicum extract and menthol and film former blending, improve preventing and treating influenza virus composition
Release.
Water component contained by above-mentioned Chinese medicine compound oral instant film preparation should be the water meeting medical domain standard, as pure
Water purification, distilled water etc..
Therefore, inventive embodiments Chinese medicine compound oral instant film preparation uses the present invention to prevent and treat influenza virus composition for having
Effect function ingredients, not only has obvious resisiting influenza virus effect.But also there is good casting film-forming performance, soft and tough
Property, safety non-toxic, and embodiment of the present invention preventing and treating influenza virus composition release can be made good, high with film former blending.
Another aspect, on the basis of embodiment of the present invention Chinese medicine compound oral instant film preparation above, the present invention implements
Example provides a kind of preparation method of Chinese medicine compound oral instant film preparation mentioned above.In one embodiment, in the embodiment of the present invention
Medicine compound oral dissolving films formulation preparation method comprises the steps:
Step S01: weigh each component raw material respectively according to component contained by Chinese medicine compound oral instant film preparation；
Step S02: the Dendranthema indicum extract, menthol glucomannoglycan and the softening agent that step S01 are weighed add water group
Mixed processing is carried out in Fen.
Wherein, component contained by the film preparation of Chinese medicine compound oral instant described in above-mentioned steps S01 and each constituent content are as above
Described in literary composition Chinese medicine compound oral instant film preparation, in order to save length, do not repeat them here.
Mixed processing in above-mentioned steps S02 can be medical material conventional method method for mixing, it is also possible to directly use stirring
The mode of mixing, it would however also be possible to employ the mode etc. of supersound process, the most in which way, can as long as be capable of each component
Uniform dissolution or be dispersed in water formed stable dispersion system colloidal sol.
In a preferred embodiment, by the Dendranthema indicum extract weighed, menthol glucomannoglycan and soft in above-mentioned steps S02
The method carrying out mixed processing in soft dose of addition water component is as follows:
By described glucomannoglycan water dissolution, stir to being completely dissolved into collosol state while add waterside, it is thus achieved that glucomannoglycan
Colloidal sol；
By described menthol water dissolution, it is configured to menthol aqueous solution；
When the sodium hydroxide solution of 1%-2% is heated up to 85-100 DEG C, under agitation adds softening agent, be subsequently cooled to
30-40 DEG C, filtration treatment, filtrate PH controls to be 8-9, obtains softening agent emulsion；In one embodiment, ovum phosphorus selected by this softening agent
At least one in fat, glycerol, sorbitol.
By described Dendranthema indicum extract water dissolution, it is configured to Dendranthema indicum solution of extract；
Described menthol aqueous solution is added and after glucomannoglycan colloidal sol carries out mixing treatment, adds described lecithin emulsions
Continue mixing treatment.
Wherein, it is thus achieved that the step of glucomannoglycan colloidal sol, be configured to the step of menthol aqueous solution, obtain lecithin emulsions
Step, it is configured to the step of Dendranthema indicum solution of extract and there is no the requirement of sequencing.By above-mentioned mixed processing mode,
Each component can be made to be uniformly dispersed, form stable colloidal sol, to improve Chinese medicine compound oral instant membrane quality of forming film, improve anti-current
Influenza Virus preventing and treating influenza virus composition stably discharges, and improves the pharmacodynamic stability of Chinese medicine compound oral instant film preparation.
Therefore, the preparation method of embodiment of the present invention Chinese medicine compound oral instant membrane ensure that Chinese medicine compound oral instant
Film preparation efficacy stability, safety non-toxic, low cost, commercial viability is good.
Below by way of preventing and treating influenza virus composition, Chinese medicine compound oral instant membrane and preparation method thereof specific embodiment
The present invention will be further described.
1 preventing and treating influenza virus composition embodiment
Embodiment 11
The present embodiment provides one preventing and treating influenza virus composition.Described preventing and treating influenza virus composition comprises effective dose
Dendranthema indicum extract and menthol；Wherein, the weight ratio of described Dendranthema indicum extract and menthol is 10:0.5.
Wherein, described Dendranthema indicum extract extracts as follows:
Dendranthema indicum extracts dry flower and uses water extraction to extract: dry flower pulverized 30 mesh sieves, and solid-liquid ratio is 1:10, soaked
Extract 1 hour (temperature is 95 DEG C) after 30 minutes, then filter extracting solution.Second time adds 10 times of water again and puies forward (condition same first
Secondary), merge secondary filtrate and be concentrated into 1:1 or 1:1.2.
Embodiment 12
The present embodiment provides one preventing and treating influenza virus composition.Described preventing and treating influenza virus composition comprises effective dose
Dendranthema indicum extract and menthol；Wherein, the weight ratio of described Dendranthema indicum extract and menthol is (0.1-0.5): (1-
10)。
Wherein, described Dendranthema indicum extract extracts as follows:
Using Dendranthema indicum to be dried stem and leaf is raw material, uses dynamic circumfluence method to extract.
Embodiment 13
The dissolving of menthol: because menthol is slightly soluble in water, therefore after should first amount used accurately being discharged when molten menthol
Put beaker adds 100ml water heat stirring to being completely dissolved.
Embodiment 14
The quality standard of glucomannoglycan: purity >=90% of glucomannoglycan, should the accounting for of powder diameter≤0.125mm >=
90%.The glucomannoglycan reaching this standard has strong bacteriostasis, and therefore in this compound recipe, film former also has function and effect.
Chinese medicine compound oral instant membrane example of formulations
Embodiment 21
The present embodiment provides a kind of Chinese medicine compound oral instant film preparation.Described Chinese medicine compound oral instant film preparation contains
The preventing and treating influenza virus composition of above-described embodiment 11, possibly together with glucomannoglycan and softening agent and water with described Chinese medicine compound mouth
Chamber dissolving films total formulation weight amount is 100% meter, and described Dendranthema indicum extract, menthol glucomannoglycan and softening agent and water are each
Component percentages is as follows:
Wherein, the preparation method of described Chinese medicine compound oral instant film preparation is as follows:
S11: according to the compatibility content of the Chinese medicine compound oral instant membrane formulation components of the present embodiment 21, use dissolved in purified water
Glucomannoglycan, stirs to being completely dissolved into collosol state while add waterside；
S12: use dissolved in purified water menthol；
S13: with the sodium hydroxide solution dissolving lecithin of 1%-2%.When sodium hydroxide solution is heated up to 85-100 DEG C,
Under agitation add such as lecithin, be subsequently cooled to 30-40 DEG C, cross 100 mesh sieves, emulsion PH be 8-9 be alkalescence；
S14: with dissolved in purified water Dendranthema indicum extract；
S15: menthol liquid is added and adds lecithin emulsions continuation stirring extremely after stirring in glucomannoglycan colloidal sol
Till even.
Embodiment 22
The present embodiment provides a kind of Chinese medicine compound oral instant film preparation.Described Chinese medicine compound oral instant film preparation contains
The preventing and treating influenza virus composition of above-described embodiment 12, possibly together with glucomannoglycan and softening agent and water with described Chinese medicine compound mouth
Chamber dissolving films total formulation weight amount is 100% meter, and described Dendranthema indicum extract, menthol glucomannoglycan and softening agent and water are each
Component percentages is as follows:
Wherein, the preparation method of described Chinese medicine compound oral instant film preparation is with reference to the preparation method in embodiment 21.
Correlation test
The Chinese medicine compound oral instant film preparation provided by above-described embodiment 21 carries out following clinical experiment:
1. one-tenth film test:
The Chinese medicine compound oral instant film preparation directly provided by above-described embodiment 21 is put on glass plate, with flat after one minute
Mouth scraper plate is coated with one time on glass gently, then it is dried to can taking off to put greenhouse.Therefore, during the embodiment of the present invention provides
Medicine compound oral dissolving films preparation good film-forming property, and there is preferable toughness.
2. antiviral study in vitro example:
The Chinese medicine compound oral instant film preparation provided by above-described embodiment 21-22 uses mtt assay to carry out extracorporeal antivirus effect
Experiment.Making cytotoxicity experiment by Madin-Darby canine kidney(cell line) (MDCK) (MDCK), experiment uses conventional panel method, measures median effective dose respectively
(IC50), therapeutic index (TI) and viral suppression, measurement result is shown in Table 1.
The table 1 Chinese medicine compound oral instant film preparation film antivirus action effect to influenza A H1N1 influenza virus
Table 1 Chinese medicine compound oral instant film preparation film is to A type H1N1The antivirus action effect of influenza virus
Above-mentioned table 1 test result shows, the Chinese medicine compound oral instant film preparation made containing Dendranthema indicum extract exists
External have preferable antiviral effect, and wherein stem and leaf extract is better than flower extract.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all essences in the present invention
Any amendment, equivalent and the improvement etc. made within god and principle, should be included within the scope of the present invention.
Claims (8)
1. a preventing and treating influenza virus composition, it is characterised in that: comprise Dendranthema indicum extract and the menthol of effective dose；Its
In, the weight ratio of described Dendranthema indicum extract and menthol is (0.1-0.5): (1-10).
Preventing and treating influenza virus composition the most according to claim 1, it is characterised in that: described Dendranthema indicum extract be by
Extract according to following extraction conditions and obtain:
Use Dendranthema indicum to be dried stem and/or leaf is raw material, described raw material is carried out reflux, extract, process；At described reflux, extract,
The temperature of reason is 60 DEG C-80 DEG C, pressure 0.6-0.8 atmospheric pressure, reflux, extract, 1-2 hour, and the solvent that reflux, extract, processes is water.
Preventing and treating influenza virus composition the most according to claim 2, it is characterised in that: described raw material with water volume ratio is
1:(10-30)。
4. according to the arbitrary described preventing and treating influenza virus composition of claim 1-3, it is characterised in that: described influenza virus is first
Type H1N1。
5. a Chinese medicine compound oral instant film preparation, it is characterised in that: it contains the arbitrary described preventing and treating stream of claim 1-4
Influenza Virus compositions, possibly together with glucomannoglycan and softening agent and water, with described Chinese medicine compound oral instant membrane total formulation weight amount
Being 100% meter, described Dendranthema indicum extract, menthol glucomannoglycan and softening agent and each component percentages of water are as follows:
Chinese medicine compound oral instant film preparation the most according to claim 5, it is characterised in that: ovum phosphorus selected by described softening agent
At least one in fat, glycerol, sorbitol.
7. the preparation method of a Chinese medicine compound oral instant film preparation, it is characterised in that: comprise the steps:
Each component is weighed respectively former according to component contained by the arbitrary described Chinese medicine compound oral instant film preparation of claim 5-6
Material；
The Dendranthema indicum extract weighed, menthol glucomannoglycan and softening agent are added in water component and carries out mixed processing.
Preparation method the most according to claim 4, it is characterised in that: described by the Dendranthema indicum extract weighed, Herba Menthae
The method carrying out mixed processing in alcohol glucomannoglycan and softening agent addition water component is as follows:
By described glucomannoglycan water dissolution, stir to being completely dissolved into collosol state while add waterside, it is thus achieved that glucomannoglycan colloidal sol；
By described menthol water dissolution, it is configured to menthol aqueous solution；
When the sodium hydroxide solution of 1%-2% is heated up to 85-100 DEG C, under agitation adds lecithin, be subsequently cooled to 30-
40 DEG C, filtration treatment, filtrate PH controls to be 8-9, obtains lecithin emulsions；
By described Dendranthema indicum extract water dissolution, it is configured to Dendranthema indicum solution of extract；
Described menthol aqueous solution is added and after glucomannoglycan colloidal sol carries out mixing treatment, adds the continuation of described lecithin emulsions
Mixing treatment.
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| JP2018138521A (en) * | 2017-02-24 | 2018-09-06 | 学校法人福岡大学 | Release control film containing water-soluble polysaccharide as main component |
| KR102524075B1 (en) * | 2022-06-22 | 2023-04-21 | 한국 한의학 연구원 | Composition for preventing, ameliorating or treating coronavirus infectious disease comprising herbal medicine extract as effective component |
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| KR102524075B1 (en) * | 2022-06-22 | 2023-04-21 | 한국 한의학 연구원 | Composition for preventing, ameliorating or treating coronavirus infectious disease comprising herbal medicine extract as effective component |
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| Publication number | Publication date |
|---|---|
| CN106236807B (en) | 2020-08-14 |
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