CN109451744B - 用于危重患者的死亡预后的生物标志物 - Google Patents
用于危重患者的死亡预后的生物标志物 Download PDFInfo
- Publication number
- CN109451744B CN109451744B CN201780039163.2A CN201780039163A CN109451744B CN 109451744 B CN109451744 B CN 109451744B CN 201780039163 A CN201780039163 A CN 201780039163A CN 109451744 B CN109451744 B CN 109451744B
- Authority
- CN
- China
- Prior art keywords
- patient
- polynucleotide
- death
- biomarker
- sepsis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
- C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
- G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
- G16B25/20—Polymerase chain reaction [PCR]; Primer or probe design; Probe optimisation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
- C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
- C12Q2537/165—Mathematical modelling, e.g. logarithm, ratio
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/20—Dermatological disorders
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/26—Infectious diseases, e.g. generalised sepsis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Medical Informatics (AREA)
- Theoretical Computer Science (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Evolutionary Biology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210792075.2A CN115161389A (zh) | 2016-06-26 | 2017-04-25 | 用于危重患者的死亡预后的生物标志物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662354789P | 2016-06-26 | 2016-06-26 | |
| US62/354,789 | 2016-06-26 | ||
| PCT/US2017/029468 WO2018004806A1 (en) | 2016-06-26 | 2017-04-25 | Biomarkers for use in prognosis of mortality in critically ill patients |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210792075.2A Division CN115161389A (zh) | 2016-06-26 | 2017-04-25 | 用于危重患者的死亡预后的生物标志物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109451744A CN109451744A (zh) | 2019-03-08 |
| CN109451744B true CN109451744B (zh) | 2022-08-05 |
Family
ID=60786346
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201780039163.2A Active CN109451744B (zh) | 2016-06-26 | 2017-04-25 | 用于危重患者的死亡预后的生物标志物 |
| CN202210792075.2A Pending CN115161389A (zh) | 2016-06-26 | 2017-04-25 | 用于危重患者的死亡预后的生物标志物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210792075.2A Pending CN115161389A (zh) | 2016-06-26 | 2017-04-25 | 用于危重患者的死亡预后的生物标志物 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US10344332B2 (enExample) |
| EP (1) | EP3475473A4 (enExample) |
| JP (2) | JP2019530878A (enExample) |
| CN (2) | CN109451744B (enExample) |
| AU (2) | AU2017289600A1 (enExample) |
| CA (1) | CA3024724A1 (enExample) |
| WO (1) | WO2018004806A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109451744B (zh) * | 2016-06-26 | 2022-08-05 | 斯坦福大学托管董事会 | 用于危重患者的死亡预后的生物标志物 |
| WO2018140256A1 (en) * | 2017-01-17 | 2018-08-02 | Duke University | Gene expression signatures useful to predict or diagnose sepsis and methods of using the same |
| EP3759235B1 (en) * | 2018-02-27 | 2025-02-19 | The Board Of Trustees Of The Leland Stanford Junior University | Classifier for identification of robust sepsis subtypes |
| CA3133639A1 (en) * | 2019-03-22 | 2020-10-01 | Inflammatix, Inc. | Systems and methods for deriving and optimizing classifiers from multiple datasets |
| JP2022530323A (ja) * | 2019-04-28 | 2022-06-29 | ビスビュー メディカル,インコーポレイテッド | デジタル検出能力および無線接続性を有する分子診断デバイス |
| BR112022008068A2 (pt) * | 2019-10-28 | 2022-07-12 | Hoffmann La Roche | Métodos para auxiliar na avaliação de risco de um paciente com suspeita de sepse e método implementado por computador para a avaliação de um paciente com suspeita de sepse |
| JP2023525489A (ja) * | 2020-04-29 | 2023-06-16 | インフラマティックス インコーポレイテッド | ウイルス感染症を有する対象の死亡率リスクの決定 |
| WO2022066963A1 (en) * | 2020-09-25 | 2022-03-31 | The Board Of Trustees Of The Leland Stanford Junior University | Method for determining a virally-infected subject's risk of developing severe symptoms |
| CN114606308A (zh) * | 2022-01-26 | 2022-06-10 | 江门市中心医院 | 脓毒症ards的预后与治疗标志物 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1738908A (zh) * | 2002-11-12 | 2006-02-22 | 贝克顿迪金森公司 | 使用生物标记谱诊断脓毒或者sirs |
| CN101208602A (zh) * | 2005-04-15 | 2008-06-25 | 贝克顿迪金森公司 | 脓毒症的诊断 |
| CN103492590A (zh) * | 2011-02-22 | 2014-01-01 | 卡里斯生命科学卢森堡控股有限责任公司 | 循环生物标志物 |
| WO2015135071A1 (en) * | 2014-03-14 | 2015-09-17 | Hancock Robert E W | Diagnostic for sepsis |
| CN105518153A (zh) * | 2013-06-20 | 2016-04-20 | 因姆内克斯普雷斯私人有限公司 | 生物标志物鉴定 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5245615A (en) | 1991-06-06 | 1993-09-14 | International Business Machines Corporation | Diagnostic system and interface for a personal computer |
| NZ333718A (en) | 1996-07-12 | 2000-10-27 | First Opinion Corp | Computerized medical diagnostic system utilizing list-based processing |
| US20050196817A1 (en) | 2004-01-20 | 2005-09-08 | Molecular Staging Inc. | Biomarkers for sepsis |
| DE102005050933A1 (de) * | 2005-10-21 | 2007-04-26 | Justus-Liebig-Universität Giessen | Erfindung betreffend Expressionsprofile zur Vorhersage von septischen Zuständen |
| ATE472611T1 (de) * | 2005-11-25 | 2010-07-15 | Trinity College Dublin | Verfahren zur diagnose von sepsis durch analyse von cytokine mrna expression |
| EP2388594A1 (en) * | 2010-05-17 | 2011-11-23 | Roche Diagnostics GmbH | GDF-15 based means and methods for survival and recovery prediction in acute inflammation |
| US20110312521A1 (en) * | 2010-06-17 | 2011-12-22 | Baylor Research Institute | Genomic Transcriptional Analysis as a Tool for Identification of Pathogenic Diseases |
| US20120034214A1 (en) * | 2010-07-22 | 2012-02-09 | Isis Innovation Limited | Methods and kits for determining the prognosis of pulmonary sarcoidosis |
| CN103403549B (zh) * | 2011-01-11 | 2015-11-25 | 美迪恩斯生命科技株式会社 | 败血症的预后的预测方法 |
| WO2013040099A2 (en) * | 2011-09-12 | 2013-03-21 | Langley Raymond | Sepsis prognosis biomarkers |
| CN109451744B (zh) * | 2016-06-26 | 2022-08-05 | 斯坦福大学托管董事会 | 用于危重患者的死亡预后的生物标志物 |
-
2017
- 2017-04-25 CN CN201780039163.2A patent/CN109451744B/zh active Active
- 2017-04-25 CA CA3024724A patent/CA3024724A1/en active Pending
- 2017-04-25 AU AU2017289600A patent/AU2017289600A1/en not_active Abandoned
- 2017-04-25 JP JP2019519961A patent/JP2019530878A/ja active Pending
- 2017-04-25 EP EP17820714.8A patent/EP3475473A4/en not_active Withdrawn
- 2017-04-25 CN CN202210792075.2A patent/CN115161389A/zh active Pending
- 2017-04-25 US US15/553,152 patent/US10344332B2/en active Active
- 2017-04-25 WO PCT/US2017/029468 patent/WO2018004806A1/en not_active Ceased
-
2018
- 2018-12-11 US US16/216,846 patent/US11608531B2/en active Active
-
2019
- 2019-05-20 US US16/417,358 patent/US10648033B2/en not_active Expired - Fee Related
-
2022
- 2022-07-08 JP JP2022110659A patent/JP2022153436A/ja active Pending
- 2022-08-01 AU AU2022211785A patent/AU2022211785A1/en not_active Abandoned
-
2023
- 2023-02-08 US US18/107,477 patent/US20240011096A1/en not_active Abandoned
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1738908A (zh) * | 2002-11-12 | 2006-02-22 | 贝克顿迪金森公司 | 使用生物标记谱诊断脓毒或者sirs |
| CN101208602A (zh) * | 2005-04-15 | 2008-06-25 | 贝克顿迪金森公司 | 脓毒症的诊断 |
| CN103492590A (zh) * | 2011-02-22 | 2014-01-01 | 卡里斯生命科学卢森堡控股有限责任公司 | 循环生物标志物 |
| CN105518153A (zh) * | 2013-06-20 | 2016-04-20 | 因姆内克斯普雷斯私人有限公司 | 生物标志物鉴定 |
| WO2015135071A1 (en) * | 2014-03-14 | 2015-09-17 | Hancock Robert E W | Diagnostic for sepsis |
Non-Patent Citations (4)
| Title |
|---|
| An integrated transcriptome and expressed variant analysis of sepsis survival and death;Ephraim L Tsalik et al.;《Genome Medicine》;20141126;第6卷;第1-15页 * |
| Mortality prediction in sepsis via gene expression analysis: a community approach;Timothy E Sweeney et al.;《bioRxiv preprint》;20161219;第1-25页 * |
| Prospective validation of an 11‑gene mRNA host response score for mortality risk stratifcation in the intensive care unit;Andrew R. Moore et al.;《Scientifc Reports》;20210622;第11卷;第1-9页 * |
| 脓毒症早期预警生物标志物的研究进展;许程 等;《检验医学》;20150531;第30卷(第5期);第533-536页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CA3024724A1 (en) | 2018-01-04 |
| US20190106750A1 (en) | 2019-04-11 |
| US11608531B2 (en) | 2023-03-21 |
| US20190300959A1 (en) | 2019-10-03 |
| EP3475473A1 (en) | 2019-05-01 |
| US20180274031A1 (en) | 2018-09-27 |
| AU2022211785A1 (en) | 2022-08-25 |
| US10344332B2 (en) | 2019-07-09 |
| WO2018004806A1 (en) | 2018-01-04 |
| CN115161389A (zh) | 2022-10-11 |
| JP2022153436A (ja) | 2022-10-12 |
| US10648033B2 (en) | 2020-05-12 |
| CN109451744A (zh) | 2019-03-08 |
| JP2019530878A (ja) | 2019-10-24 |
| AU2017289600A1 (en) | 2018-12-06 |
| US20240011096A1 (en) | 2024-01-11 |
| EP3475473A4 (en) | 2020-01-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN109451744B (zh) | 用于危重患者的死亡预后的生物标志物 | |
| US20220127673A1 (en) | Methods for diagnosis of bacterial and viral infections | |
| US20230227911A1 (en) | Methods for Diagnosis of Sepsis | |
| EP3362579B1 (en) | Methods for diagnosis of tuberculosis | |
| WO2022235765A2 (en) | Systems and methods for assessing a bacterial or viral status of a sample | |
| WO2020096796A1 (en) | Method for predicting severe dengue |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |