CN109432169A - A kind of Chinese medicine composition and preparation method thereof promoting wound healing and application - Google Patents
A kind of Chinese medicine composition and preparation method thereof promoting wound healing and application Download PDFInfo
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- CN109432169A CN109432169A CN201811540965.4A CN201811540965A CN109432169A CN 109432169 A CN109432169 A CN 109432169A CN 201811540965 A CN201811540965 A CN 201811540965A CN 109432169 A CN109432169 A CN 109432169A
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- 239000003814 drug Substances 0.000 title claims abstract description 56
- 239000000203 mixture Substances 0.000 title claims abstract description 38
- 230000029663 wound healing Effects 0.000 title claims abstract description 22
- 230000001737 promoting effect Effects 0.000 title claims abstract description 9
- 238000002360 preparation method Methods 0.000 title abstract description 5
- 238000004519 manufacturing process Methods 0.000 claims abstract description 17
- 241000717739 Boswellia sacra Species 0.000 claims abstract description 13
- 239000004863 Frankincense Substances 0.000 claims abstract description 13
- 235000003181 Panax pseudoginseng Nutrition 0.000 claims abstract description 13
- 244000131316 Panax pseudoginseng Species 0.000 claims abstract description 13
- 239000002994 raw material Substances 0.000 claims abstract description 13
- 235000003255 Carthamus tinctorius Nutrition 0.000 claims abstract description 12
- 244000020518 Carthamus tinctorius Species 0.000 claims abstract description 12
- 238000000638 solvent extraction Methods 0.000 claims abstract description 10
- 239000003960 organic solvent Substances 0.000 claims abstract description 5
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims description 9
- 239000007788 liquid Substances 0.000 claims description 8
- 229940079593 drug Drugs 0.000 claims description 7
- 238000012805 post-processing Methods 0.000 claims description 5
- 238000002203 pretreatment Methods 0.000 claims description 5
- 230000023597 hemostasis Effects 0.000 claims description 3
- 238000000605 extraction Methods 0.000 claims description 2
- 238000010298 pulverizing process Methods 0.000 claims description 2
- 239000011343 solid material Substances 0.000 claims description 2
- 238000004659 sterilization and disinfection Methods 0.000 claims description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 230000000717 retained effect Effects 0.000 claims 1
- 206010052428 Wound Diseases 0.000 abstract description 18
- 208000027418 Wounds and injury Diseases 0.000 abstract description 18
- 230000000694 effects Effects 0.000 abstract description 17
- 208000002193 Pain Diseases 0.000 abstract description 12
- 230000008961 swelling Effects 0.000 abstract description 8
- 230000003213 activating effect Effects 0.000 abstract description 5
- 230000004089 microcirculation Effects 0.000 abstract description 5
- 238000000034 method Methods 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 206010061218 Inflammation Diseases 0.000 description 3
- 206010033799 Paralysis Diseases 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 238000011084 recovery Methods 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 208000032843 Hemorrhage Diseases 0.000 description 2
- 206010039509 Scab Diseases 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000000472 traumatic effect Effects 0.000 description 2
- 230000008736 traumatic injury Effects 0.000 description 2
- 208000006820 Arthralgia Diseases 0.000 description 1
- NIPNSKYNPDTRPC-UHFFFAOYSA-N N-[2-oxo-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 NIPNSKYNPDTRPC-UHFFFAOYSA-N 0.000 description 1
- 208000025747 Rheumatic disease Diseases 0.000 description 1
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- 206010053476 Traumatic haemorrhage Diseases 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000019522 cellular metabolic process Effects 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
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- 230000008929 regeneration Effects 0.000 description 1
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- 230000000552 rheumatic effect Effects 0.000 description 1
- 235000005713 safflower oil Nutrition 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- 238000006748 scratching Methods 0.000 description 1
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- 239000007787 solid Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/237—Notopterygium
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract
The present invention provides a kind of Chinese medicine composition and preparation method thereof for promoting wound healing, and the present invention relates to field of traditional Chinese medicine preparations.Chinese medicine composition of the invention includes following raw material: 20-30 parts of Rhizoma Chuanxiong, 15-25 parts of olibanum, 6-12 parts of safflower, 6-15 parts of ramulus cinnamomi, 10-20 parts of Cortex Eucommiae, 20-30 parts of pseudo-ginseng, 15-30 parts of Rhizoma Et Radix Notopterygii.The production method of Chinese medicine composition of the invention are as follows: above-mentioned raw materials are added in organic solvent and carry out solvent extraction.Chinese medicine composition of the invention not only has the effect of activating microcirculation and removing stasis medicinal, swelling and pain relieving, moreover it is possible to it is effectively facilitated wound healing, it is high to the cure rate of wound, and it is short to cure the period.Production method of the invention is simple, and fabrication cycle is short, low manufacture cost.
Description
Technical field
The present invention relates to field of traditional Chinese medicine preparations, more particularly to a kind of Chinese medicine composition for promoting wound healing and its production
Methods and applications.
Background technique
It happens occasionally in life because accidentally falling, colliding or scratching the swollen or bleeding that causes to become silted up, we would generally use each medicine
Water process wound and swollen place.The slow effect of oral medicine, and took multipair liver and kidney causes to bear.Common work on the market
The liquid medicine of blood stagnation resolvation has bonesetting liquid, safflower oil, HUOLUO YOU etc., and since various liquid medicine ingredients are different, the scope of application also has one
Fixed difference, but these liquid medicine all cannot directly handle traumatic hemorrhage, can not promote wound healing.
Summary of the invention
Based on this, it is necessary to which the technical issues of being directed to existing traumatic slow effect, cannot promoting wound provides a kind of promotion
The Chinese medicine composition of wound healing.
A kind of Chinese medicine composition promoting wound healing, the raw material including following parts by weight: 20-30 parts of Rhizoma Chuanxiong, olibanum 15-
25 parts, 6-12 parts of safflower, 6-15 parts of ramulus cinnamomi, 10-20 parts of Cortex Eucommiae, 20-30 parts of pseudo-ginseng, 15-30 parts of Rhizoma Et Radix Notopterygii.
Traditional Chinese medicine ingredients in the Chinese medicine composition can not only be effectively facilitated wound healing, high to the cure rate of wound, control
More the period is short, also has the effect of activating microcirculation and removing stasis medicinal, swelling and pain relieving.
It in one of the embodiments, further include 800-1500 parts of organic solvent in Chinese medicine composition.
Organic solvent is the ethanol water of volumetric concentration 75% in one of the embodiments,.
Chinese medicine composition includes the raw material of following parts by weight in one of the embodiments: 25 parts of Rhizoma Chuanxiong, 20 parts of olibanum,
9 parts of safflower, 11 parts of ramulus cinnamomi, 15 parts of Cortex Eucommiae, 25 parts of pseudo-ginseng, 23 parts of Rhizoma Et Radix Notopterygii, 1150 parts of ethanol water of 75%.
The invention also discloses a kind of production methods of the Chinese medicine composition of above-mentioned promotion wound healing.
The Chinese medicine composition of this method production, can not only be effectively facilitated wound healing, high to the cure rate of wound, cure
Period is short, also has the effect of activating microcirculation and removing stasis medicinal, swelling and pain relieving.
The production method of Chinese medicine composition includes solvent extraction step in one of the embodiments: by Rhizoma Chuanxiong, olibanum,
Safflower, ramulus cinnamomi, Cortex Eucommiae, pseudo-ginseng and Rhizoma Et Radix Notopterygii are placed in 75% ethanol water and impregnate extraction.
Pre-treatment step, the pre-treatment step are additionally provided with before solvent extraction step in one of the embodiments, are as follows: will
Rhizoma Chuanxiong, olibanum, safflower, ramulus cinnamomi, Cortex Eucommiae, pseudo-ginseng and Rhizoma Et Radix Notopterygii are dried, then pulverization.
The time of solvent extraction is 20-30 days in one of the embodiments,.
Post-processing step, post-processing step are additionally provided with after solvent extraction step in one of the embodiments, are as follows: by solid
Raw material filtering, retains liquid portion.
The invention also discloses a kind of Chinese medicine composition of above-mentioned promotion wound healing hemostasis, detumescence or disinfection drug
In application.
The Chinese medicine composition that the production method obtains can not only be effectively facilitated wound healing, high to the cure rate of wound,
The healing period is short, also has the effect of activating microcirculation and removing stasis medicinal, swelling and pain relieving.
Compared with prior art, the invention has the following advantages:
The Chinese medicine composition of promotion wound healing of the invention, has the function of activating microcirculation and removing stasis medicinal and blood dredging collateral, can swash comprehensively
Living cells makes impaired cell repair regeneration promotion wound healing；Have the function of wind-expelling pain-stopping, antibacterial anti-inflammatory；With removing
Internal rubbish reinforce human body cell metabolism, restore blood vessel elasticity, broad-spectrum antiseptic, and stimulating central nervous system improves white blood cell content etc.
Effect.Experiment shows the Chinese medicine composition using promotion wound healing of the invention, treatment wound, treating swelling and pain by traumatic injury, rheumatism paralysis
With good effect, effective percentage up to 84% or more.
In addition, the Chinese medicine type that the present invention selects is less, low manufacture cost, fabrication cycle is short, and data effect is good, favorably
It is promoted the use of in a wide range of, mitigates patient economy burden, and reduce the feeling of pain of patient body.
Specific embodiment
It to facilitate the understanding of the present invention, below will be to invention is more fully described.But the present invention can be to be permitted
Mostly different form is realized, however it is not limited to embodiment described herein.On the contrary, purpose of providing these embodiments is makes
It is more thorough and comprehensive to the understanding of the disclosure.
Unless otherwise defined, all technical and scientific terms used herein and belong to technical field of the invention
The normally understood meaning of technical staff is identical.Term as used herein in the specification of the present invention is intended merely to description tool
The purpose of the embodiment of body, it is not intended that in the limitation present invention.
Embodiment 1
It is a kind of promote wound healing Chinese medicine composition, the raw material including following parts by weight: 25 parts of Rhizoma Chuanxiong, 20 parts of olibanum,
9 parts of safflower, 11 parts of ramulus cinnamomi, 15 parts of Cortex Eucommiae, 25 parts of pseudo-ginseng, 23 parts of Rhizoma Et Radix Notopterygii, 1150 parts of ethanol water of 75%.
Embodiment 2
It is a kind of promote wound healing Chinese medicine composition, the raw material including following parts by weight: 20 parts of Rhizoma Chuanxiong, 25 parts of olibanum,
6 parts of safflower, 15 parts of ramulus cinnamomi, 10 parts of Cortex Eucommiae, 30 parts of pseudo-ginseng, 15 parts of Rhizoma Et Radix Notopterygii, 1500 parts of ethanol water of 75%.
Embodiment 3
It is a kind of promote wound healing Chinese medicine composition, the raw material including following parts by weight: 30 parts of Rhizoma Chuanxiong, 15 parts of olibanum,
12 parts of safflower, 6 parts of ramulus cinnamomi, 20 parts of Cortex Eucommiae, 20 parts of pseudo-ginseng, 30 parts of Rhizoma Et Radix Notopterygii, 800 parts of ethanol water of 75%.
Embodiment 4
A kind of production method for the Chinese medicine composition promoting wound healing, comprising the following steps:
Step 1: pre-treatment, by 25 parts of Rhizoma Chuanxiong, 20 parts of olibanum, 9 parts of safflower, 11 parts of ramulus cinnamomi, 15 parts of Cortex Eucommiae, 25 parts of pseudo-ginseng,
23 parts of Rhizoma Et Radix Notopterygii drying, grind into powder；
Step 2: 1150 part 75% of ethanol water is added in Xiang Shangshu powder, places and extracts 25 days for solvent extraction；
Step 3: post-processing will filter by the liquid medicine of step 2 processing, remove solid material, retain liquid portion.
To be contrasted with above-described embodiment, provided with following reference examples:
Reference examples 1
A kind of Chinese medicine composition is compared to the difference of embodiment 1, rhizome of chuanxiong is lacked in raw material.
Reference examples 2
A kind of Chinese medicine composition is compared to the difference of embodiment 1,15 parts of radix achyranthis bidentatae is increased in raw material.
Reference examples 3
A kind of Chinese medicine composition is compared to the difference of embodiment 4, the Rhizoma Chuanxiong in raw material is replaced with Radix Salviae Miltiorrhizae.
The product that above-described embodiment and reference examples are obtained carries out following application experiment, and wherein patient is random received
Patient, age range are 16-55 years old, the following data counted to patient's treatment condition.
Experimental example 1
600 traumatic patients are grouped, respectively treatment group and control group, to treatment group using above-described embodiment 1-3's
Chinese medicine composition is treated, and is respectively corresponded as treatment group 1-3, and control group is treated using the drug of reference examples 1-3, respectively
Correspond to control group 1-3.The pharmaceutical composition of above embodiments and reference examples is prepared referring to the method for embodiment 4.
To the above patient use corresponding drug therapy, daily wound medicine for external application three times, continuously outside apply 10 days, if
Period incrustation can stop exterior coating treatment.It is counted after the treatment of a cycle, therapeutic effect is as shown in table 1:
1 treatment group of table and control group treat Clinical efficacy comparison
Note: slight wound, which refers to, only injures epidermis, wound slight bleeding, remaining is non-slight wound patient；
Recovery from illness: wound incrustation can take off after referring to treatment；
It is effective: to refer to and stop blooding after processing；
It is invalid: to refer to wound inflammation after processing.
It can be seen that by upper table for slight wound patient, product of the invention can effectively stop blooding, and embodiment 1-3
Composition effect has optimal hemostasis incrustation effect due to comparative example 1-3, the especially composition of embodiment 1, can be at 1 day
Interior recovery from illness；For non-slight wound patient, after outer painting product of the present invention, the patient of 6-16% is formed a scab again by infection inflammation process to fully recover from an illness
More, the patient of 84-94% does not have inflammation, recovery from illness of forming a scab after the treatment of 3-5.
Experimental example 2
600 treating swelling and pain by traumatic injury patients are grouped, respectively treatment group and control group, above-described embodiment 1- is used to treatment group
3 Chinese medicine composition is treated, and is respectively corresponded as treatment group 1-3, and control group is treated using the drug of reference examples 1-3,
It respectively corresponds as control group 1-3.The pharmaceutical composition of above embodiments and reference examples is prepared into referring to the method for embodiment 4
It arrives.
The above patient is treated using corresponding drug, medicine for external application three times, continuously applies 10 outside at swelling and pain daily
It.It is counted after the exterior coating treatment of a cycle, therapeutic effect is as shown in table 2:
2 treatment group of table and control group treat Clinical efficacy comparison
Note: slight wound refers to that the stasis of blood swells area no more than 16cm2, non-slight wound refer to the stasis of blood swell area be more than 16cm2；
It is effective: detumescence；
Invalid: swelling and pain do not disappear.
It can be seen that by upper table for slight wound patient, detumescence effective percentage of the invention reaches 88-100%, especially implements
The effect of example 1 is best.The effect of embodiment is good compared to reference examples 1-3 effect very much.
Experimental example 3
300 rheumatic arthralgia patients are grouped, respectively treatment group and control group, above-described embodiment 1- is used to treatment group
3 Chinese medicine composition is treated, and is respectively corresponded as treatment group 1-3, and control group is treated using the drug of reference examples 1-3,
It respectively corresponds as control group 1-3.The pharmaceutical composition of above embodiments and reference examples is prepared into referring to the method for embodiment 4
It arrives.
The above patient is treated using corresponding drug, medicine for external application is three times, continuous outer at rheumatism paralysis daily
It applies 20 days.It is counted after the exterior coating treatment of a cycle, therapeutic effect is as shown in table 3:
3 treatment group of table and control group treat Clinical efficacy comparison
| Group | Number of cases (n) | Effectively (n) | Efficient (%) | In vain (n) | Inefficiency (%) | Averagely fully recover period (d) |
| Treatment group 1 | 50 | 48 | 96 | 2 | 4 | 10 |
| Treatment group 2 | 50 | 43 | 86 | 7 | 14 | 13 |
| Treatment group 3 | 50 | 45 | 90 | 5 | 10 | 12 |
| Control group 1 | 50 | 26 | 52 | 24 | 48 | 19 |
| Control group 2 | 50 | 40 | 80 | 10 | 20 | 16 |
| Control group 3 | 50 | 36 | 72 | 14 | 28 | 17 |
Note: effectively: pain obviously weakens or disappears；
Invalid: feeling of pain is without decrease.
86-96%, especially embodiment are reached by the effective percentage that upper table can be seen that present invention treatment rheumatism paralysis patient
1 effect is best.The effect of embodiment is good compared to reference examples 1-3 effect very much.
Each technical characteristic of embodiment described above can be combined arbitrarily, for simplicity of description, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, all should be considered as described in this specification.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously
It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art
It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to protection of the invention
Range.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.
Claims (10)
1. a kind of Chinese medicine composition for promoting wound healing, which is characterized in that the raw material including following parts by weight: Rhizoma Chuanxiong 20-30
Part, 15-25 parts of olibanum, 6-12 parts of safflower, 6-15 parts of ramulus cinnamomi, 10-20 parts of Cortex Eucommiae, 20-30 parts of pseudo-ginseng, 15-30 parts of Rhizoma Et Radix Notopterygii.
2. Chinese medicine composition according to claim 1, which is characterized in that further include 800-1500 parts of organic solvent.
3. Chinese medicine composition according to claim 2, which is characterized in that the organic solvent is the second of volumetric concentration 75%
Alcohol solution.
4. Chinese medicine composition according to claim 1-3, which is characterized in that the Chinese medicine composition includes following
The raw material of parts by weight: 25 parts of Rhizoma Chuanxiong, 20 parts of olibanum, 9 parts of safflower, 11 parts of ramulus cinnamomi, 15 parts of Cortex Eucommiae, 25 parts of pseudo-ginseng, 23 parts of Rhizoma Et Radix Notopterygii,
1150 parts of 75% ethanol water.
5. a kind of production method of Chinese medicine composition described in claim 1.
6. production method according to claim 5, which is characterized in that including solvent extraction step: by Rhizoma Chuanxiong, olibanum, red
Flower, ramulus cinnamomi, Cortex Eucommiae, pseudo-ginseng and Rhizoma Et Radix Notopterygii are placed in 75% ethanol water and impregnate extraction.
7. production method according to claim 5, which is characterized in that be additionally provided with pre-treatment step before the solvent extraction step
Suddenly, the pre-treatment step are as follows: dry Rhizoma Chuanxiong, olibanum, safflower, ramulus cinnamomi, Cortex Eucommiae, pseudo-ginseng and Rhizoma Et Radix Notopterygii, then pulverization.
8. production method according to claim 5, which is characterized in that the time of the solvent extraction is 20-30 days.
9. production method according to claim 5, which is characterized in that be additionally provided with post-processing step after the solvent extraction step
Suddenly, the post-processing step are as follows: solid material is filtered, liquid portion is retained.
10. a kind of described in any item Chinese medicine compositions for promoting wound healing of claim 1-4 are being used to prepare hemostasis, detumescence
Or the application in the drug of disinfection.
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Citations (3)
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| CN1243010A (en) * | 1999-06-04 | 2000-02-02 | 董长举 | Chinese-medicine pain-relieving tincture liniment for wounds |
| CN1411864A (en) * | 2002-11-07 | 2003-04-23 | 王勇智 | High-energy biological vector preparation for expelling cold, promoting blood circulation and removing obatruction in channel and its preparation method |
| CN104027394A (en) * | 2014-06-17 | 2014-09-10 | 李柳强 | Traditional Chinese medicine preparation for treating fracture and traumatic injury |
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2018
- 2018-12-17 CN CN201811540965.4A patent/CN109432169A/en active Pending
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|---|---|---|---|---|
| CN1243010A (en) * | 1999-06-04 | 2000-02-02 | 董长举 | Chinese-medicine pain-relieving tincture liniment for wounds |
| CN1411864A (en) * | 2002-11-07 | 2003-04-23 | 王勇智 | High-energy biological vector preparation for expelling cold, promoting blood circulation and removing obatruction in channel and its preparation method |
| CN104027394A (en) * | 2014-06-17 | 2014-09-10 | 李柳强 | Traditional Chinese medicine preparation for treating fracture and traumatic injury |
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Application publication date: 20190308 |