CN109430286A - A kind of bactericidal composition and its application of the sulfonamide ester of ether containing azoles and Mancozeb - Google Patents
A kind of bactericidal composition and its application of the sulfonamide ester of ether containing azoles and Mancozeb Download PDFInfo
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- CN109430286A CN109430286A CN201811605757.8A CN201811605757A CN109430286A CN 109430286 A CN109430286 A CN 109430286A CN 201811605757 A CN201811605757 A CN 201811605757A CN 109430286 A CN109430286 A CN 109430286A
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- mancozeb
- sulfonamide ester
- ether sulfonamide
- bactericidal composition
- azoles ether
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
- A01N47/12—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing a —O—CO—N< group, or a thio analogue thereof, neither directly attached to a ring nor the nitrogen atom being a member of a heterocyclic ring
- A01N47/14—Di-thio analogues thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention belongs to technical field of pesticide, it is related to a kind of bactericidal composition containing azoles ether sulfonamide ester and Mancozeb and its application, bactericidal composition is made of active constituent and auxiliary ingredients for pesticide preparations, in particular, active constituent is made of azoles ether sulfonamide ester and Mancozeb by weight 1:20~20:1.The present invention compounds azoles ether sulfonamide ester and Mancozeb within the scope of certain proportion, achieve the synergistic function of highly significant, expand antimicrobial spectrum, slow down the generation of drug resistance, extend medicament service life, and compounding significantly increases drug effect, dosage reduces, and control cost is effectively reduced.The present composition has particularly preferred control efficiency for cucumber downy mildew.
Description
Technical field
The present invention relates to disinfectant use in agriculture fields, specifically, being related to a kind of microbicide compositions and its application, especially
It is related to a kind of bactericidal composition for preventing and treating cucumber downy mildew and its application.
Background technique
Cucumber downy mildew is the more serious disease of cucumber, all can be aggrieved from seedling stage to strain, mainly cause harm blade and stem.
The disease is suitable for that onset temperature is 16 DEG C~24 DEG C, and irregular chlorisis yellowish-brown spot occurs for Seedling Stage morbidity, cotyledon front, at
Strain morbidity, mostly since greenhouse forward position, there is water stain shape, light green fleck, front in blade reverse side in middle and lower part before this for morbidity strain
It does not show, rear scab is gradually expanded, front exposed.It is badly in need of currently on the market good to the quick-acting of cucumber downy mildew, lasting period length
Medicament.
In 2016, Central China Normal University's Yang Guang richness etc. (Chinese patent, CN201610003201, CN201610095896)
It was found that azoles ether sulfonamide ester has preferable control efficiency to cucumber downy mildew, rice sheath blight disease.Shown in its chemical structure following (I).
Mancozeb is a kind of excellent protective fungicide, belongs to low-toxin farm chemicals.Since its bactericidal range is wide, is not likely to produce
Resistance, control efficiency is substantially better than other similar fungicide, so dosage is always large tonnage product in the world.It is domestic at present
Most composite bactericides are all formulated with Mancozeb processing, and manganese, zinc microelement have apparent rush to strengthen crop, increase production and make
With.
The mixture of different pesticide species is the common methods for preventing and treating agriculture resistance disease.It is screened, is screened by formulation of pesticide
Reasonable formula out, can effectively improve practical control efficiency, reduce dosage, reduce cost, delay the generation of disease drug resistance,
It is the important means of disease comprehensive treatment.
Azoles ether sulfonamide ester and Mancozeb mixture are used to prevent and treat cucumber downy mildew there is no relevant report at present.
Summary of the invention
The object of the present invention is to provide a kind of composition pesticide with synergistic effect and safety and environmental protection, for preventing and treating cucumber
Downy mildew realizes compound synergic compared with existing pesticide control, dosage is reduced, to achieve the purpose that reduce cost.Specifically
Be related to the bactericidal composition of azoles ether sulfonamide ester and Mancozeb.
The present inventor has found by in-depth study, by the azoles ether sulfonamide ester and Mancozeb of following specific structures
It is used in compounding, not only without offsetting azoles ether sulfonamide ester and the respective drug effect of Mancozeb, on the contrary, also having obviously synergy
Effect, significantly improves the control efficiency of fungus-caused plant disease, especially significant to the control efficiency of cucumber downy mildew
It improves, has thus completed the present invention.
To achieve the goals above, the present invention provides a kind of bactericidal compositions, wherein the bactericidal composition activity at
Dividing includes azoles ether sulfonamide ester and Mancozeb, and the azoles ether sulfonamide ester is formula (I) compound,
The present invention provides application of the above-mentioned microbicide compositions in prevention and treatment cucumber downy mildew.
The present invention provides a kind of preparations as prepared by above-mentioned microbicide compositions, wherein the dosage form of the preparation is
Aqueous emulsion, suspoemulsion or water dispersible granules.
The present invention provides application of the above-mentioned preparation in prevention and treatment cucumber downy mildew.
The microbicide compositions provided according to the present invention, have obvious synergistic function, and bactericidal effect is good, medication
It is at low cost, it is not easy to produce resistance, it is good to crop safety.Microbicide compositions especially provided by the invention are to cucumber downy mildew
Control efficiency is significant.
Other features and advantages of the present invention will the following detailed description will be given in the detailed implementation section.
Specific embodiment
For the synergistic effect for determining two kinds of effective component of azoles ether sulfonamide ester and Mancozeb compounding, applicant uses this first
Two kinds of ingredients carry out indoor bactericidal activity tests, and after the action character for analyzing two kinds of effective component, we are by pair of test
As being set to Cuba artificial downy mildew (Pseudoperonospora cubensis), which can cause
The downy mildew of cucumber.
The test method of indoor bactericidal activity: reference " National Standard of the People's Republic of China GB/T17980.26-2000 ",
Using the bioactivity of spore suspension spray inoculation method measurement medicament.Select the consistent potting cucumber seedling of growing way, reagent spray
Naturally dry after processing, for 24 hours afterwards with writing brush dip distillation washing take disease leaf back sporangium, be made into sporangia suspension (2-3 ×
105A/ml), sporangia suspension is uniformly sprayed on cucumber leaves with inoculation sprayer (pressure 0.1MPa), then will be connect
Cucumber seedling moves in artificial climate room (relative humidity 100%, temperature are 21-23 DEG C, light dark period 14h/10h) training after kind
It supports.90% or so moisturizing of relative humidity is maintained to induce afterwards for 24 hours, 7-8d backsight blank control incidence carries out classification investigation, presses
Disease refers to calculating preventive effect.The EC of each medicament is found out by control efficiency50, according to Sun Yunpei, ((Y-P Sun) method will be everywhere in measurement
The EC of reason50It is converted into practical poison exponent (ATI)；According to the mixture ratio, theoretical toxicity index (TTI) is obtained, by following public affairs
The co-toxicity coefficient (CTC) of formula calculating mixture.
Investigation method: every cell takes 4 points of investigation at random, and every is looked into two plants, the whole blades of every plant of investigation.
The grade scale of disease index:
0 grade: disease-free spot；
1 grade: lesion area accounts for 5% or less entire leaf area；
3 grades: lesion area accounts for the 6%-l0% of entire leaf area；
5 grades: lesion area accounts for the 11%-25% of entire leaf area；
7 grades: lesion area accounts for the 26%-50% of entire leaf area；
9 grades: lesion area accounts for 50% or more of entire leaf area.
Drug effect calculates: according to investigation result, calculating disease index and preventive effect according to following formula.
Co-toxicity coefficient (CTC) calculates:
Toxicity index (TI)=(EC of standard agent50The EC of/reagent agent50) X 100 (and one of A agent, B agent make
For standard agent)
Mixture actual toxicity index (ATI)=(EC of standard agent50The EC of/mixture50)X 100
There is the TI X mixture of the content+B agent of A in mixtures theoretical toxicity index (TTI)=A agent TI X mixture effective component
Imitate the content of B in ingredient
Co-toxicity coefficient (CTC)=[mixture actual toxicity index ((ATI)/mixtures theoretical toxicity index (TTI) " X 100
A agent, B agent are respectively two kinds of active constituents mutually mixed, and mixture is the mixture after A agent is mutually mixed with B agent.
Evaluation criterion: when CTC >=120, synergistic effect is shown as；When CTC≤80, antagonism is shown as；80 < CTC <
120, show as summation action.
1 azoles ether sulfonamide ester of table and Mancozeb compound the indoor virulence to cucumber downy mildew
| Processing | EC50(mg/L) | TTI | ATI | Co-toxicity coefficient (CTC) |
| Azoles ether sulfonamide ester (A) | 15.32 | |||
| Mancozeb (B) | 10.54 | |||
| A+B(40:1) | 13.54 | 101.11 | 113.15 | 111.91 |
| A+B(20:1) | 11.89 | 102.16 | 128.85 | 126.12 |
| A+B(10:1) | 10.28 | 104.12 | 149.03 | 143.13 |
| A+B(5:1) | 9.21 | 107.56 | 166.34 | 154.65 |
| A+B(1:1) | 8.23 | 122.68 | 186.15 | 151.74 |
| A+B(1:5) | 7.45 | 137.79 | 205.64 | 149.24 |
| A+B(1:10) | 7.00 | 141.23 | 218.86 | 154.97 |
| A+B(1:20) | 6.22 | 143.19 | 246.30 | 172.01 |
Remarks: the numeric ratio in bracket that W is indicated is the weight proportion of two kinds of medicaments.
Above-mentioned data are analyzed, it is apparent that when azoles ether sulfonamide ester and Mancozeb are with 1:20~20:1 ratio compounding
When, the co-toxicity coefficient (CTC) of formula is all larger than 120, there is the synergistic effect of different proportion to the prevention and control capability of cucumber downy mildew.
Can have very after determining two kinds of effective component compoundings of azoles ether sulfonamide ester and Mancozeb by indoor biometrics experiment
Good synergistic effect.The following specific examples are used to further explain the present invention in detail, but the present invention be only limited to absolutely not with
These lower embodiments.Percentage is weight percentage in formula, and used raw medicine and auxiliary agent are the purchase of other producers.
The preparation of preparation example 1:40% azoles ether sulfonamide ester-mancozeb suspending agent
15% azoles ether sulfonamide ester, 25% Mancozeb are weighed, 2%TERSPERSE 2500 (is purchased from Hensel Mann, below
It is identical), 3%TERSPERSE 4896 (being purchased from Hensel Mann, same as below), 0.2% xanthan gum, 3% white carbon black, 5% second
(trade name: the Nanjing s-29 "four news" (new ideas applied chemistry product company produces, below for glycol, 0.3% benzoic acid, 0.5% organic silicon defoamer
It is identical), deionized water adds to 100%.
Preparation method: by effective component, wetting agent, dispersing agent, antifreezing agent etc. is uniformly mixed, is added in sand mill and is ground to
After certain partial size, filtering.It adds prepared xanthan gum and is stirred until homogeneous and 40% azoles ether sulfonamide ester-Mancozeb can be obtained
Suspending agent.
The preparation of preparation example 2:15% azoles ether sulfonamide ester-Mancozeb aqueous emulsion
Weigh 10% azoles ether sulfonamide ester, 5% Mancozeb, 3% agriculture breast 2201#, 1.5% Nonyl pheno (EO=
10) ether phosphate (being purchased from Nanjing Teva-Chem. Co., Ltd., same as below), 2.5% triphenoethyl benzene phenol polyethenoxy ether phosphorus
Acid esters (agriculture breast 600# acid phosphatide, is purchased from Nanjing Teva-Chem. Co., Ltd., same as below), 2%Span-60# (are purchased from Xingtai indigo plant
Star auxiliary agent company, same as below), 1% epoxychloropropane, 20% dimethylbenzene, 10% cyclohexanone, 0.3% xanthan gum, 0.5% benzene
Formic acid, deionized water add to 100% mass parts.
Preparation method: by above-mentioned effective component, emulsifier after dispersing agent is dissolved with solvent, under conditions of high shear, adds
Enter into water phase, add xanthan gum and stir evenly, can be prepared by 15% azoles ether sulfonamide ester-Mancozeb aqueous emulsion.
The preparation of preparation example 3:60% azoles ether sulfonamide ester-mancozeb water dispersible granule
20% azoles ether sulfonamide ester is weighed, 40% Mancozeb, 3%TERSPERSE 2700 (are purchased from Hensel Mann, below
It is identical), 2% dispersing agent NNO (alkylnaphthalene sulfonate formaldehyde condensation products are purchased from Shanghai Tiantan Accessory Ingredient Co., Ltd, same as below),
3% Nekal BX (nekal), 2%K-12 lauryl sodium sulfate), 3% diatomite, 5% glucose, kaolin
Add to 100%.
Preparation method: 60% azoles ether sulfanilamide (SN) is made in above-mentioned raw materials after mixing, ultra micro air-flow crushing, granulation step
Ester-mancozeb water dispersible granule.
The preparation of preparation example 4:24% azoles ether sulfonamide ester suspending agent
Weigh 24% azoles ether sulfonamide ester, 2425,0.2% xanthan gum of 2%TERSPERSE 2500,3%TERSPERSE,
3% white carbon black, 5% ethylene glycol, 0.3% benzoic acid, 0.5% organic silicon defoamer (trade name: the Nanjing s-29 "four news" (new ideas applied chemistry
Product company produces), deionized water adds to 100%.
Preparation method: by effective component, wetting agent, dispersing agent, antifreezing agent etc. is uniformly mixed, is added in sand mill and is ground to
After certain partial size, filtering.It adds prepared xanthan gum and is stirred until homogeneous and can be prepared by 24% azoles ether sulfonamide ester suspending agent.
Embodiment: this test case prevents and treats cucumber downy mildew field control effectiveness test for illustrating
Selection above example carries out the field trial of prevention and treatment cucumber downy mildew, determines the effect of formula prevention and treatment cucumber downy mildew
Fruit, while the Contrast on effect with azoles ether sulfonamide ester and Mancozeb single dose, verify the control efficiency of the embodiment of the present invention.Specific examination
Proved recipe method is referring to GB/T17980.26-2000.Test site is Chengdu, Sichuan, and the time is on May 8th, 2018, and test is every
Four repetitions of a processing, cell random alignment, each plot area are 30m2, using back-pack electric compression sprayer, application
The same day is sunny calm, and the planting habit of all cells is identical as local planting habit, record application, specific as follows:
Investigation method are as follows: every cell takes 4 points of investigation at random, and every is looked into two plants, the whole blades of every plant of investigation.
The grade scale of disease index:
0 grade: disease-free spot；
1 grade: lesion area accounts for 5% or less entire leaf area；
3 grades: lesion area accounts for the 6%-l0% of entire leaf area；
5 grades: lesion area accounts for the 11%-25% of entire leaf area；
7 grades: lesion area accounts for the 26%-50% of entire leaf area；
9 grades: lesion area accounts for 50% or more of entire leaf area.
Drug effect calculation method: according to investigation result, disease index and preventive effect are calculated according to following formula.
In addition, application drug, active ingredient amount and test result are as shown in table 2
Field control effectiveness test of the various medicaments of table 2 to cucumber downy mildew
Can be seen that bactericidal composition provided by the invention from the above effect data has spy for prevention and treatment cucumber downy mildew
Effect, component is reasonable, has treatment plus protective effect, and bactericidal effect is good, thus, it is possible to reduce times for spraying, reduce medication at
This.More importantly its activity and the active simple superposition of bactericidal effect not instead of each component, have significant synergies,
The generation that resistance can be slowed down meets the security requirement of pesticidal preparations to crop safety.
As it can be seen that compound preparation can be very good to improve drug effect, extends the lasting period, mitigate the amount of labour of peasant, have very high
Practicability.
Claims (4)
1. a kind of bactericidal composition, which is characterized in that the active constituent of the bactericidal composition includes azoles ether sulfonamide ester and maneb
Zinc, the azoles ether sulfonamide ester are following formula (I) compounds,
Wherein, the weight ratio of azoles ether sulfonamide ester and Mancozeb is 1:20~20:1.
2. application of the microbicide compositions described in claim 1 in prevention and treatment cucumber downy mildew.
3. preparation prepared by microbicide compositions described in claim 1, wherein the dosage form of the preparation is aqueous emulsion, hangs
Emulsion or water dispersible granules.
4. application of the preparation described in claim 3 in prevention and treatment cucumber downy mildew.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104886073A (en) * | 2015-05-21 | 2015-09-09 | 华中师范大学 | Fungicide composite, and preparation and application of fungicide composite |
| CN105693638A (en) * | 2016-01-05 | 2016-06-22 | 华中师范大学 | Bactericidal compound and bactericide composition and preparation and application thereof |
| CN108184854A (en) * | 2017-12-31 | 2018-06-22 | 成都格瑞赛斯科技有限公司 | A kind of bactericidal composition and its application containing cyazofamid |
-
2018
- 2018-12-27 CN CN201811605757.8A patent/CN109430286A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104886073A (en) * | 2015-05-21 | 2015-09-09 | 华中师范大学 | Fungicide composite, and preparation and application of fungicide composite |
| CN105693638A (en) * | 2016-01-05 | 2016-06-22 | 华中师范大学 | Bactericidal compound and bactericide composition and preparation and application thereof |
| CN108184854A (en) * | 2017-12-31 | 2018-06-22 | 成都格瑞赛斯科技有限公司 | A kind of bactericidal composition and its application containing cyazofamid |
Non-Patent Citations (1)
| Title |
|---|
| 吉春明等: "防治黄瓜霜霉病有效药剂筛选及药效评价", 《天津农业科学》 * |
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