CN109394865A

CN109394865A - A kind of capsule and production method with diarrhea-relieving function

Info

Publication number: CN109394865A
Application number: CN201811551253.2A
Authority: CN
Inventors: 倪晓旺
Original assignee: Dalian Zhen Xin Technology Co Ltd
Current assignee: Dalian Zhen Xin Technology Co Ltd
Priority date: 2018-12-18
Filing date: 2018-12-18
Publication date: 2019-03-01

Abstract

The present invention relates to a kind of capsules with diarrhea-relieving function, its capsule contents composition formula is made of the following raw material: baobab fruit, hill gooseberry, thorn angle melon, Rosa roxburghii Tratt, elaeagnus conferta fruits, Ba Danmu, white garden burnet, saddle leaf, bitter numb dish, dwarf apple, Common Leafflower Herb, Chinese sumac, its nutritive value is abundant, is rich in protein, carrotene, vitamin B₁、B₂、B₃、B₆With vitamin C, anthocyanidin, more than organic acid and more than 20 kinds of amino acid, 10 microelement beneficial to human body: calcium, phosphorus, magnesium, sodium, potassium etc..The present invention has diarrhea-relieving function by scientific experimentation and Dialectical Principles composition of prescription, rational proportion, and can promote digestion, build up health, and raising body immunity, Anshen Bunao, improvement sleep, healthcare function are significant, body health benefits.

Description

A kind of capsule and production method with diarrhea-relieving function

Technical field

The present invention relates to capsule product fields, and in particular to a kind of capsule and production method with diarrhea-relieving function.

Background technique

Diarrhea is a kind of common sympton, is commonly called as " suffering from diarrhea ", refer to defecation frequency significantly more than the frequency being accustomed on ordinary days, and Excrement matter is thin, and moisture increases, or containing not digesting food or purulence blood, mucus.Diarrhea is often accompanied by defecation urgency sense, anus discomfort, loses The symptoms such as taboo.About 9L liquid enters gastrointestinal tract to normal person daily, the absorption by enteron aisle to moisture, moisture in final excrement Only about 100~200ml.If the amount of liquid into colon be more than colon absorbability or (and) absorptive capacity of colon reduces, It will lead to water discharge in excrement to increase, just generate diarrhea.Course of disease length is clinically pressed, is divided to acute and chronic two for diarrhea Class.Acute diarrhea is fallen ill sharply, and within 2~3 weeks, big polyphyly infection causes the course of disease.Chronic diarrhea refer to the course of disease two months with Recurrent diarrhea of the upper or intermittent phase in 2~4 weeks, pathogenic factor is increasingly complex, can be infectious or non-infectious factor institute It causes.

Diarrhea is the syndrome as caused by many reasons, and main clinic symptoms show as times of defecation and increase, stool Change (just matter is dilute half congealed in water sample or diarrhea with undigested food)；It can be with the diseases such as vomiting, abdominal pain, fever, thirsty, oliguria.Diarrhea serious person It can cause dehydration and electrolyte disturbance, there is certain harmfulness, so needing to be paid attention to.

Summary of the invention

The present invention provides a kind of capsule and production method with diarrhea-relieving function aiming at above-mentioned status.

Present invention employs following schemes.

A kind of capsule with diarrhea-relieving function, it is characterised in that: its capsule contents composition formula by following parts by weight raw material Composition: 500~700 parts of baobab fruit, 500~700 parts of hill gooseberry, thorn 500~700 parts of angle melon, 400~600 parts of Rosa roxburghii Tratt, sheep 400~600 parts of milk fruit, 300~400 parts of Ba Danmu, 100~140 parts of white garden burnet, 100~140 parts of saddle leaf, bitter fiber crops dish 80~ 120 parts, 80~120 parts of dwarf apple, 80~120 parts of Common Leafflower Herb, 20~30 parts of Chinese sumac, 3~5 parts of nutrition fortifier.

The production method of the capsule with diarrhea-relieving function, includes the following steps:

Step 1: quality raw materials are selected according to above-mentioned formula, and are weighed according to the above ratio；

Step 2:

Mature baobab fruit is cleaned into crust, carries out heated-air drying after stripping and slicing, within the scope of 50~90 DEG C of drying temperature, wind speed is 0.5~1.5m/s, it is 5~9 μm that the baobab fruit after drying is worn into diameter of particle with biomixer in a manner of vibromill Ultra-micro powder keeps cell wall broken, is rapidly cooled within the scope of 20~30 DEG C, obtains baobab fruit Ultramicro-powder, spare；

Mature myrtle fruit is removed into handle, gently shower is cleaned with the circulating water of room temperature, and centrifuging and taking juice is stood after mixing evenly 30min, cross 60 mesh filter screens, obtain fruit juice, be concentrated into relative density be 1.1~1.5 after, vacuum drying, then be ground into partial size be 5~ 9 μm of ultra-micro powder, it is spare；

Step 3:

After the circulating water of mature thorn angle melon room temperature is cleaned peeling, by pulp stripping and slicing, be put into blender stir at low speed with Demucilage and seed take its fruit juice after scalping deseeding, and gained are pierced angle melon juice, refrigerate spare；

Remove thorn after the circulating water of the Rosa roxburghii Tratt room temperature of fresh mature is cleaned, cuts out the seed of the inside, squeezing is put into after stripping and slicing It squeezes the juice in juice machine, crosses 80~100 mesh filter screens, obtain the sub- fruit juice of Rosa roxburghii Tratt, refrigerate spare；

By circulating water repeated flushing 3~4 times of mature elaeagnus conferta fruits room temperature, it is put into juice extractor and squeezes the juice after cleaning, excessively 80~ 100 mesh filter screens obtain elaeagnus conferta fruits fruit juice, refrigerate spare；

The resulting fruit juice of above-mentioned processing is spray-dried, dry inlet air temperature is set within the scope of 130~150 DEG C, outlet air Temperature is set within the scope of 70~90 DEG C, after crushing, crosses 600~800 meshes, extracting screen underflow obtains fine powder；

Step 4:

Above-mentioned bar of denier wood room temperature circulating water is eluriated 2~3 times, impregnates 1~3h with pure water after cleaning, the water surface is higher than above-mentioned original Expect 3~5cm；Ba Danmu after immersion is crossed 150 mesh filter screens and remove impurity, collected filter together with soak with colloid mill slurrying Liquid is made dry fruit magma and is spray-dried, within the scope of dry 130~150 DEG C of inlet air temperature, 70~90 DEG C of ranges of leaving air temp It is interior, it crushes, crosses 600~800 meshes, extracting screen underflow obtains fine powder；

Step 5:

After the white garden burnet dried first is crushed to 30~50 mesh with pulverizer, then with airslide disintegrating mill it is ground into 600~800 purposes Fine powder, drug temperature is lower than 60 DEG C when crushing；

Step 6:

The saddle leaf dried, bitter numb dish, dwarf apple are removed into impurity, chopping, after soaking in water 0.5~1h after mixing, decoct two Secondary, first time amount of water is 6~10 times of Chinese medicine weight, decocts 1~1.4h；Second of amount of water is the 5~7 of Chinese medicine weight Times, 0.5~1h is decocted, merges decoction liquor twice, is concentrated into d=1.0~1.2g/ml, is filtered, is obtained spraying after Chinese medicine extract Dry, dry inlet air temperature is set within the scope of 130~150 DEG C, and leaving air temp is set within the scope of 70~90 DEG C, is crushed, mistake 600~800 meshes, extracting screen underflow obtain fine powder；

Step 7:

The Common Leafflower Herb dried, Chinese sumac are removed into impurity, 6~10 times of volumes of medicinal material weight, volumetric concentration 40 are added in chopping ~60% ethyl alcohol, reflux or continuous circumfluence extraction 1~3 time, every time 1~2h, extracting solution recycles ethyl alcohol, obtains thick paste, spraying dry It is dry, within the scope of dry 130~150 DEG C of inlet air temperature, within the scope of 70~90 DEG C of leaving air temp, crushes, cross 600~800 meshes, take Screenings obtains fine powder；

Step 8:

Step 2 to the obtained several powder of step 7 processing and the nutrition fortifier for smashing it through 600 meshes are put into stirring It is uniformly mixed in machine, blender speed is 50~70r/min, and mixing time is 10~16min, obtains health care mixed powder, adopts With ultraviolet disinfection, within the scope of 240~280nm, sterilize ultraviolet wavelength 20~30min, carries out dry granulation, prepares Granular intermediate is packed into capsule under aseptic condition.

The pulp of above-mentioned baobab fruit is slightly sour, without many moisture, the mouthfeel tasted also like bread.

The ripening fruits average moisture content of monkey-bread tree is 8.7%, protein 2.7%, fat 0.2%, carbohydrate 73.7%, fiber Element 8.9% and ash content 5.8%, pulp vitamin C rich in, content are almost 10 times of orange content.Contain in seed Higher than blade 50% energy, energy value 18030kJ/kg, seed contain protein 33.7%, fat 30.6%, sugared content 4.8%, content of cellulose 16.9% and ash content 5.9% contain vitamin B in seed₁And vitamin C.Calcium content ratio in baobab fruit Spinach is high by 50% or more, contains higher antioxidant content, Vitamin C content is three times of single orange.

Medical value: monkey-bread tree, whole body are all medicines.Fruit, leaf and bark can be used as medicine, can with anti-inflammatory, bring down a fever, control Malaria.Its fruit, leaf and bark can be used as medicine, with nourishing the stomach cholagogue, clearing heat for detumescence, stop blooding antidiarrheal and tranquilizing and allaying excitement function Effect.Scientists decomposite a kind of substance that stomach cancer cell can be inhibited to be formed and extended from baobab, and have thus opened often Eat the secret that the African of baobab hardly gets a cancer of the stomach.The slurries of its leaf and fruit, so far still local common anti-inflammatory Drug.

Above-mentioned myrtle fruit nature and flavor: sweet in flavor；It is puckery；It is mild-natured；Channel tropism: return liver；The spleen channel, it is distributed in lung channel.

Major function: nourishing blood and hemoslasis；Puckery intestines controlling nocturnal emission with astringent drugs.The main deficiency of blood is weak；It spits blood；Nosebleed epistaxis；Internal lesion caused by overexertion hemoptysis；Hematochezia；Metrorrhagia and metrostaxis；It loses Essence；Leukorrhagia；Dysentery；Rectal prolapse；Scald；Traumatic hemorrhage.Astringing to arrest bleeding.

Root: dispelling, collateral-activating, astringing to arrest diarrhea.For acute and chronic enterogastritis, stomachache, indigestion, hepatitis, dysentery, rheumatic Arthritis, lumbar muscle strain, functional uterine bleeding, rectal prolapse；Burn and scald and reducing blood lipid and other effects are controlled in external application.

Leaf: astringing to arrest diarrhea, hemostasis.For acute gastroenteritis, indigestion, dysentery: traumatic hemorrhage is controlled in external application.

Fruit: enriching blood, and nourishes, miscarriage prevention.It is physically weak after being ill for anaemia, neurasthenia, tinnitus, spermatorrhea.

Above-mentioned thorn angle melon, nutritive value is abundant, and the seed of thorn angle melon is covered in gelatin-like substance, and pericarp is rich in vitamin C and plant fiber.Angle melon and fruit nutritive value with higher in fact is pierced, is rich in the nutrients such as iron, potassium, calcium, magnesium, wherein ferro element Content is higher, is 4 times of cherry, contains vitamin B simultaneously₁、B₂、B₃、B₆With vitamin C, anthocyanidin, carrotene and water-soluble Property dietary fiber etc., there is antibacterial anti-inflammatory, beauty and skin care, cleaning enteron aisle, toxin expelling, weight reducing, promote digest, build up health, improving Body immunity improves sleep, Anshen Bunao, body-building promoting blood circulation and other effects.In addition, thorn angle melon or a kind of rare no syrup Fruit is very suitable to the elderly and patients with diabetes mellitus.

The fruit of above-mentioned Rosa roxburghii Tratt is also the first-class raw material of processing health food simultaneously, and mature Rosa roxburghii Tratt is fleshy hypertrophy, taste Sour-sweet, fruit is rich in more than sugar, vitamin, carrotene, organic acid and more than 20 kinds of amino acid, the 10 micro member beneficial to human body Element and superoxide dismutase.Especially Vitamin C content is high, be it is highest in current fruit, in every 100 grams of fresh fruits 841.58~3541.13 milligrams of content, it is 50 times of citrus, 10 times of Kiwi berry, there is the laudatory title of " king of vitamin C ".Its Flower, leaf fruit, seed can be used as medicine；There is stomach invigorating, help digestion, nourish, the effect of antidiarrheal.

Medical value [function] root: digestion-promoting spleen-invigorating, astringing to arrest diarrhea.Fruit: relieving summer-heat helps digestion.

[curing mainly] root: dyspeptic abdominal distention, dysentery, enteritis, spontaneous sweating, spermatorrhea, leukorrhea, menorrhalgia, hemorrhoid hemorrhage.Fruit: Vitamin C deficiency is controlled, and for making preventing cancer and delay sanility medicine.

Above-mentioned elaeagnus conferta fruits, sour, every hectogram fresh fruit contains 2.45 grams of protein, 90.6 grams of moisture, 2.3 grams fatty, carbon aquation 5.1 grams of object of conjunction, 1.45 milligrams of total acid content, 20.6 milligrams of calcium, 57.2 milligrams of phosphorus, 3.15 milligrams of carrotene, vitamin B₂0.7 milli Gram, 30 milligrams of vitamin C.To abscess of throat, flu controls asthma, empty cough, chronic bronchitis is relieving cough and asthma, and astringing to arrest diarrhea has Effect.

Above-mentioned Ba Danmu nutritive value is very high.According to chemical examination, vegetable oil 55-61% is contained in Ba Danmu, protein 28% forms sediment Powder, sugar 10-11%, and contain a small amount of vitamin A, B₁、B₂With digestive ferment, almond element enzyme, almond at, calcium, magnesium, sodium, potassium, Simultaneously containing 18 kinds of microelements such as iron, cobalts.More than ten grains are chewed carefully before daily sleep, boiled water is swept away, and long-term consumption, night can be all night It sleep soundly no dream, passive protective physical fitness significantly increases, and keeps strong.The property that Ba Danmu has clearing lung-heat, solves famine, cold dispelling, wind dispelling, antidiarrheal Can, it is typically used as relieving cough and removing sputum, is to control tracheitis, asthma, can also control gastroenteritis and acid alkali poisoning etc., skin can be protected, moreover it is possible to Intestinal health is helped, blood glucose level is maintained.

Above-mentioned white garden burnet controls cold long, the cold pain in face, tripe abdomen pain.

It is bitter, puckery, it is cold in nature.

Major function: cooling blood and hemostasis, astringing to arrest diarrhea.

1. controlling hemoptysis of pulmonary tuberculosis, spit blood, nosebleed epistaxis, metrorrhagia, enteritis, dysentery, indigestion.

Furunculosis is controlled 2. applying；It grinds to spread and controls traumatic hemorrhage

Above-mentioned saddle leaf meridian distribution of property and flavor: root: it is sour, puckery, it puts down.

Leaf, sprout: it is bitter, puckery, it is cool.

Major function: root: antidiarrheal is calmed the nerves, analgesic, dissipating bind.For diarrhea, nervous function disease, arthralgia and myalgia；Neck is controlled in external application Scrofula.

Leaf, sprout: solution wet poison, putrefaction-removing granulation-promoting.For pemphigus, stubborn dermatitis, skin eczema, sore carbuncle festers, burn and scald.

Above-mentioned bitter numb dish, nature and flavor: bitter；It is cold in nature.

Usage and dosage: for oral administration: decoction, 10~15g；Or it grinds, each 3g.External application: it is appropriate, it applies；Or it grinds tune and applies；Or It decocts as a steam-wash.

Textual criticism: 1. " Roster of Medicine Plant in Guangxi ": antidiarrheal, detumescence.Treating snakebite, urinary calculus." 2. Shaanxi Chinese herbal medicine ": heat-clearing solution Poison, purte the white, cool blood are stopped blooding, analgesic, menstruation regulating, promoting blood circulation, removing necrosis, promoting granulation.Control nameless sores or boils, eczema of scrotum, pneumonia, bruise damage Wound, fracture.

Effect: prevention and treatment anaemia, health care of relieving summer heat, clearing heat and detoxicating, bactericidal antiphlogistic.

Above-mentioned dwarf apple is medicinal: [major function] antidiarrheal dysentery.Main dysentery；It vomits and diarrhoea.

[usage and dosage] is for oral administration: decoction, 15~30g；Or it grinds；Or wine brewing.

Above-mentioned Common Leafflower Herb, herb have the benefits of removing toxic substances, anti-inflammatory, clearing away heat to stop diarrhea, diuresis, can control Akamu swelling and pain, enteritis, diarrhea, dysentery Disease, hepatitis, infantile malnutrition, nephritic dropsy, urinary tract infections etc..

Above-mentioned Chinese sumac, root, leaf, flower and fruit can be used as medicine, and have clearing heat and detoxicating, relaxing tendons and activating collaterals, dissipating stasis and stanching bleeding, relieving diarrhea with astringents The benefits of.

Capsule of the present invention with diarrhea-relieving function, it is characterised in that: its capsule contents composition formula is by following weight Part raw material composition: 550~650 parts of baobab fruit, 550~650 parts of hill gooseberry, thorn 550~650 parts of angle melon, Rosa roxburghii Tratt 450~ 550 parts, 450~550 parts of elaeagnus conferta fruits, 320~380 parts of Ba Danmu, 110~130 parts of white garden burnet, 110~130 parts of saddle leaf, hardship 90~110 parts of numb dish, 90~110 parts of dwarf apple, 90~110 parts of Common Leafflower Herb, 20~30 parts of Chinese sumac, 4 parts of nutrition fortifier.

Capsule of the present invention with diarrhea-relieving function, it is characterised in that: its capsule contents composition formula is by following weight The raw material composition of part: 600 parts of baobab fruit, 600 parts of hill gooseberry, 600 parts of angle melon of thorn, Rosa roxburghii Tratt 500 parts, elaeagnus conferta fruits 500 part, bar 350 parts of denier wood, 120 parts of white garden burnet, 120 parts of saddle leaf, bitter numb 100 parts of dish, 100 parts of dwarf apple, 100 parts of Common Leafflower Herb, Chinese sumac 25 parts, 4 parts of nutrition fortifier.

Capsule of the present invention with diarrhea-relieving function, it is characterised in that: the nutrition fortifier is amino acid, micro One or more of element or vitamin；The amino acid is lysine, threonine；The microelement is gluconic acid Zinc, calcium gluconate, ferrous gluconate；The vitamin is vitamin B₁, vitamin B₂Or vitamin C.

The production method of capsule of the present invention with diarrhea-relieving function, it is characterised in that:, will be in above-mentioned steps two Ripe baobab fruit cleans crust, carries out heated-air drying after stripping and slicing, and within the scope of 70 DEG C of drying temperature, wind speed 1m/s will be dried Baobab fruit afterwards wears into the ultra-micro powder that diameter of particle is 7 μm with biomixer in a manner of vibromill, keeps cell wall broken, It is rapidly cooled within the scope of 25 DEG C, obtains baobab fruit Ultramicro-powder, it is spare；

Mature myrtle fruit is removed into handle, gently shower is cleaned with the circulating water of room temperature, and centrifuging and taking juice is stood after mixing evenly 30min crosses 60 mesh filter screens, obtains fruit juice, is concentrated into after relative density is 1.3, vacuum drying, then being ground into partial size is 7 μm super Micropowder, it is spare；

The production method of capsule of the present invention with diarrhea-relieving function, it is characterised in that: in above-mentioned steps three, by maturation After piercing the clean peeling of circulating water of angle melon room temperature, by pulp stripping and slicing, it is put into blender and stirs at low speed with demucilage and seed, Its fruit juice is taken after scalping deseeding, and gained is pierced into angle melon juice, is refrigerated spare；

Remove thorn after the circulating water of the Rosa roxburghii Tratt room temperature of fresh mature is cleaned, cuts out the seed of the inside, squeezing is put into after stripping and slicing It squeezes the juice in juice machine, crosses 90 mesh filter screens, obtain the sub- fruit juice of Rosa roxburghii Tratt, refrigerate spare；

It by circulating water repeated flushing 3 times of mature elaeagnus conferta fruits room temperature, is put into juice extractor and squeezes the juice after cleaning, cross the filter of 90 mesh Net obtains elaeagnus conferta fruits fruit juice, refrigerates spare；

The resulting fruit juice of above-mentioned processing is spray-dried, dry inlet air temperature is set within the scope of 140 DEG C, and leaving air temp is set It is scheduled within the scope of 80 DEG C, after crushing, crosses 700 meshes, extracting screen underflow obtains fine powder.

The production method of capsule of the present invention with diarrhea-relieving function, it is characterised in that:, will be upper in above-mentioned steps four It states Ba Danmu to be eluriated 3 times with room temperature circulating water, impregnates 2h with pure water after cleaning, the water surface is higher than above-mentioned raw materials 4cm；After impregnating Ba Danmu together with soak, with colloid mill slurrying, cross 150 mesh filter screens and remove impurity, collect filtrate, dry fruit magma is made and simultaneously sprays Mist is dry, within the scope of dry 140 DEG C of inlet air temperature, within the scope of 80 DEG C of leaving air temp, crushes, crosses 700 meshes, extracting screen underflow obtains Fine powder.

The production method of capsule of the present invention with diarrhea-relieving function, it is characterised in that: in above-mentioned steps five, will shine After dry white garden burnet is first crushed to 40 mesh with pulverizer, then with airslide disintegrating mill it is ground into 700 targeted fine powders, medicine warm when crushing Degree is lower than 60 DEG C.

The production method of capsule of the present invention with diarrhea-relieving function, it is characterised in that: in above-mentioned steps six, will shine Dry saddle leaf, bitter numb dish, dwarf apple remove impurity, chopping, after soaking in water 0.8h after mixing, decoct twice, for the first time plus Water is 8 times of Chinese medicine weight, decocts 1.2h；Second of amount of water is 6 times of Chinese medicine weight, decocts 0.8h, and merging is decocted twice Boil liquid is concentrated into d=1.1g/ml, and filtering is spray-dried after obtaining Chinese medicine extract, and dry inlet air temperature is set in 140 DEG C of models In enclosing, leaving air temp is set within the scope of 80 DEG C, is crushed, and 700 meshes are crossed, and extracting screen underflow obtains fine powder.

The production method of capsule of the present invention with diarrhea-relieving function, it is characterised in that: in above-mentioned steps seven, will shine Dry Common Leafflower Herb, Chinese sumac remove impurity, and 8 times of volumes of medicinal material weight are added, the ethyl alcohol that volumetric concentration is 50%, reflux in chopping Or continuous circumfluence extraction 2 times, each 1.5h, extracting solution recycles ethyl alcohol, obtains thick paste, is spray-dried, dry 140 DEG C of models of inlet air temperature In enclosing, within the scope of 80 DEG C of leaving air temp, crushes, cross 700 meshes, extracting screen underflow obtains fine powder；

In above-mentioned steps eight, by step 2 to nutrition step 7 processing obtained several powder and smash it through 600 meshes Hardening agent is put into blender and is uniformly mixed, and blender speed is 60r/min, mixing time 13min, obtains health care mixing Powder, using ultraviolet disinfection, ultraviolet wavelength is within the scope of 260nm, and sterilize 25min, carries out dry granulation, prepares graininess Intermediate is packed into capsule under aseptic condition.

From the foregoing, it will be observed that the present invention compared with existing conventional capsule, there is following progress.

There is the capsule of diarrhea-relieving function, capsule contents composition formula is made of the following raw material: baobab fruit, peach in the present invention Golden ma, thorn angle melon, Rosa roxburghii Tratt, elaeagnus conferta fruits, Ba Danmu, white garden burnet, saddle leaf, bitter numb dish, dwarf apple, Common Leafflower Herb, Chinese sumac, Nutritive value is abundant, is rich in protein, carrotene, vitamin B₁、B₂、B₃、B₆With vitamin C, anthocyanidin, organic acid and More than more than 20 kinds of amino acid, 10 microelement beneficial to human body: calcium, phosphorus, magnesium, sodium, potassium etc..The present invention by scientific experimentation and Dialectical Principles composition of prescription, rational proportion have diarrhea-relieving function, and can promote digestion, build up health, raising body immunity, Anshen Bunao, improvement sleep, healthcare function are significant, body health benefits.

Specific embodiment

In order to thoroughly understand the present invention, detailed formula composition will be proposed in following description.Obviously, of the invention to apply Row is not limited to specific details appreciated by those skilled in the art.Presently preferred embodiments of the present invention is described in detail as follows, However other than these detailed descriptions, the present invention can also have other embodiments.

Embodiment 1:

A kind of capsule with diarrhea-relieving function, capsule contents composition formula are composed of the following raw materials in parts by weight: baobab fruit 600 Part, 600 parts of hill gooseberry, 600 parts of angle melon of thorn, Rosa roxburghii Tratt 500 parts, 500 parts of elaeagnus conferta fruits, 350 parts of Ba Danmu, 120 parts of white garden burnet, horse 120 parts of saddle leaf, bitter numb 100 parts of dish, 100 parts of dwarf apple, 100 parts of Common Leafflower Herb, 25 parts of Chinese sumac, 4 parts of nutrition fortifier.

Step 2:

Mature baobab fruit is cleaned into crust, carries out heated-air drying after stripping and slicing, within the scope of 70 DEG C of drying temperature, wind speed 1m/ Baobab fruit after drying is worn into the ultra-micro powder that diameter of particle is 5 μm by s with biomixer in a manner of vibromill, is made thin Cell wall is broken, is rapidly cooled within the scope of 25 DEG C, obtains baobab fruit Ultramicro-powder, spare；

Mature myrtle fruit is removed into handle, gently shower is cleaned with the circulating water of room temperature, and centrifuging and taking juice is stood after mixing evenly 30min crosses 60 mesh filter screens, obtains fruit juice, is concentrated into after relative density is 1.3, vacuum drying, then being ground into partial size is 5 μm super Micropowder, it is spare；

Step 3:

Remove thorn after the circulating water of the Rosa roxburghii Tratt room temperature of fresh mature is cleaned, cuts out the seed of the inside, squeezing is put into after stripping and slicing It squeezes the juice in juice machine, crosses 100 mesh filter screens, obtain the sub- fruit juice of Rosa roxburghii Tratt, refrigerate spare；

It by circulating water repeated flushing 3 times of mature elaeagnus conferta fruits room temperature, is put into juice extractor and squeezes the juice after cleaning, cross the filter of 100 mesh Net obtains elaeagnus conferta fruits fruit juice, refrigerates spare；

The resulting fruit juice of above-mentioned processing is spray-dried, dry inlet air temperature is set within the scope of 140 DEG C, and leaving air temp is set It is scheduled within the scope of 80 DEG C, after crushing, crosses 800 meshes, extracting screen underflow obtains fine powder；

Step 4:

Above-mentioned bar of denier wood room temperature circulating water is eluriated 3 times, impregnates 2h with pure water after cleaning, the water surface is higher than above-mentioned raw materials 4cm； Ba Danmu after immersion is crossed 150 mesh filter screens and remove impurity, collect filtrate, dry fruit is made together with soak with colloid mill slurrying Magma is simultaneously spray-dried, and within the scope of dry 140 DEG C of inlet air temperature, within the scope of 80 DEG C of leaving air temp, is crushed, is crossed 800 meshes, take sieve Lower object, obtains fine powder；

Step 5:

After the white garden burnet dried first is crushed to 40 mesh with pulverizer, then with airslide disintegrating mill 800 targeted fine powders are ground into, crushed When drug temperature be lower than 60 DEG C；

Step 6:

The saddle leaf dried, bitter numb dish, dwarf apple are removed into impurity, chopping, after soaking in water 0.8h after mixing, decocted twice, First time amount of water is 8 times of Chinese medicine weight, decocts 1.2h；Second of amount of water is 6 times of Chinese medicine weight, decocts 0.8h, is closed And decoction liquor twice, it is concentrated into d=1.1g/ml, filters, is spray-dried after obtaining Chinese medicine extract, dry inlet air temperature is set in Within the scope of 140 DEG C, leaving air temp is set within the scope of 80 DEG C, is crushed, and 800 meshes are crossed, and extracting screen underflow obtains fine powder；

Step 7:

The Common Leafflower Herb dried, Chinese sumac are removed into impurity, 8 times of volumes of medicinal material weight are added in chopping, volumetric concentration is 50% Ethyl alcohol, reflux or continuous circumfluence extraction 2 times, each 1.5h, extracting solution recycles ethyl alcohol, obtains thick paste, is spray-dried, dry air inlet temperature It spends within the scope of 140 DEG C, within the scope of 80 DEG C of leaving air temp, crushes, cross 800 meshes, extracting screen underflow obtains fine powder；

Step 8:

Step 2 to the obtained several powder of step 7 processing and the nutrition fortifier for smashing it through 600 meshes are put into stirring It is uniformly mixed in machine, blender speed is 60r/min, and mixing time 13min obtains health care mixed powder, using ultraviolet light Sterilizing, ultraviolet wavelength is within the scope of 260nm, and sterilize 25min, carries out dry granulation, graininess intermediate is prepared, in sterile Under the conditions of be packed into capsule；

Step 9:

By capsule finished product random sampling made from step 8, send laboratory to be sampled detection by batch, sealed again after sampling observation is qualified It is packed into library.

Embodiment 2:

A kind of capsule with diarrhea-relieving function, capsule contents composition formula are composed of the following raw materials in parts by weight: baobab fruit 650 Part, 650 parts of hill gooseberry, 650 parts of angle melon of thorn, Rosa roxburghii Tratt 600 parts, 550 parts of elaeagnus conferta fruits, 400 parts of Ba Danmu, 140 parts of white garden burnet, horse 140 parts of saddle leaf, bitter numb 120 parts of dish, 110 parts of dwarf apple, 110 parts of Common Leafflower Herb, 30 parts of Chinese sumac, 5 parts of nutrition fortifier.

Step 2:

Mature baobab fruit is cleaned into crust, carries out heated-air drying after stripping and slicing, within the scope of 90 DEG C of drying temperature, wind speed is Baobab fruit after drying is worn into the ultra-micro powder that diameter of particle is 7 μm by 0.5m/s with biomixer in a manner of vibromill, Keep cell wall broken, is rapidly cooled within the scope of 30 DEG C, obtains baobab fruit Ultramicro-powder, it is spare；

Mature myrtle fruit is removed into handle, gently shower is cleaned with the circulating water of room temperature, and centrifuging and taking juice is stood after mixing evenly 30min crosses 60 mesh filter screens, obtains fruit juice, is concentrated into after relative density is 1.5, vacuum drying, then being ground into partial size is 7 μm super Micropowder, it is spare；

Step 3:

The resulting fruit juice of above-mentioned processing is spray-dried, dry inlet air temperature is set within the scope of 150 DEG C, and leaving air temp is set It is scheduled within the scope of 90 DEG C, after crushing, crosses 700 meshes, extracting screen underflow obtains fine powder；

Step 4:

Above-mentioned bar of denier wood room temperature circulating water is eluriated 3 times, impregnates 3h with pure water after cleaning, the water surface is higher than above-mentioned raw materials 5cm； Ba Danmu after immersion is crossed 150 mesh filter screens and remove impurity, collect filtrate, dry fruit is made together with soak with colloid mill slurrying Magma is simultaneously spray-dried, and within the scope of dry 150 DEG C of inlet air temperature, within the scope of 90 DEG C of leaving air temp, is crushed, is crossed 700 meshes, take sieve Lower object, obtains fine powder；

Step 5:

After the white garden burnet dried first is crushed to 50 mesh with pulverizer, then with airslide disintegrating mill 700 targeted fine powders are ground into, crushed When drug temperature be lower than 60 DEG C；

Step 6:

The saddle leaf dried, bitter numb dish, dwarf apple are removed into impurity, chopping, after soaking in water 1h after mixing, decocted twice, the Amount of water is 10 times of Chinese medicine weight, decocts 1h；Second of amount of water is 7 times of Chinese medicine weight, decocts 0.5h, merges two Secondary decoction liquor is concentrated into d=1.2g/ml, and filtering is spray-dried after obtaining Chinese medicine extract, and dry inlet air temperature is set in 150 Within the scope of DEG C, leaving air temp is set within the scope of 90 DEG C, is crushed, and 700 meshes are crossed, and extracting screen underflow obtains fine powder；

Step 7:

The Common Leafflower Herb dried, Chinese sumac are removed into impurity, 10 times of volumes of medicinal material weight are added in chopping, volumetric concentration is 60% Ethyl alcohol, reflux or continuous circumfluence extraction 3 times, each 1h, extracting solution recycles ethyl alcohol, obtains thick paste, is spray-dried, dry inlet air temperature Within the scope of 150 DEG C, within the scope of 90 DEG C of leaving air temp, crushes, cross 700 meshes, extracting screen underflow obtains fine powder；

Step 8:

Step 2 to the obtained several powder of step 7 processing and the nutrition fortifier for smashing it through 600 meshes are put into stirring It is uniformly mixed in machine, blender speed 70r/min, mixing time 10min is obtained health care mixed powder, gone out using ultraviolet light Bacterium, ultraviolet wavelength is within the scope of 280nm, and sterilize 20min, carries out dry granulation, graininess intermediate is prepared, in sterile item Capsule is packed under part；

Step 9:

Embodiment 3:

A kind of capsule with diarrhea-relieving function, capsule contents composition formula are composed of the following raw materials in parts by weight: baobab fruit 550 Part, 500 parts of hill gooseberry, 500 parts of angle melon of thorn, Rosa roxburghii Tratt 450 parts, 400 parts of elaeagnus conferta fruits, 300 parts of Ba Danmu, 110 parts of white garden burnet, horse 100 parts of saddle leaf, bitter numb 90 parts of dish, 80 parts of dwarf apple, 80 parts of Common Leafflower Herb, 20 parts of Chinese sumac, 3 parts of nutrition fortifier.

Step 2:

Mature baobab fruit is cleaned into crust, carries out heated-air drying after stripping and slicing, within the scope of 50 DEG C of drying temperature, wind speed is Baobab fruit after drying is worn into the ultra-micro powder that diameter of particle is 9 μm by 1.5m/s with biomixer in a manner of vibromill, Keep cell wall broken, is rapidly cooled within the scope of 20 DEG C, obtains baobab fruit Ultramicro-powder, it is spare；

Mature myrtle fruit is removed into handle, gently shower is cleaned with the circulating water of room temperature, and centrifuging and taking juice is stood after mixing evenly 30min crosses 60 mesh filter screens, obtains fruit juice, is concentrated into after relative density is 1.1, vacuum drying, then being ground into partial size is 9 μm super Micropowder, it is spare；

Step 3:

Remove thorn after the circulating water of the Rosa roxburghii Tratt room temperature of fresh mature is cleaned, cuts out the seed of the inside, squeezing is put into after stripping and slicing It squeezes the juice in juice machine, crosses 80 mesh filter screens, obtain the sub- fruit juice of Rosa roxburghii Tratt, refrigerate spare；

It by circulating water repeated flushing 3 times of mature elaeagnus conferta fruits room temperature, is put into juice extractor and squeezes the juice after cleaning, cross the filter of 80 mesh Net obtains elaeagnus conferta fruits fruit juice, refrigerates spare；

The resulting fruit juice of above-mentioned processing is spray-dried, dry inlet air temperature is set within the scope of 130 DEG C, and leaving air temp is set It is scheduled within the scope of 70 DEG C, after crushing, crosses 600 meshes, extracting screen underflow obtains fine powder；

Step 4:

Above-mentioned bar of denier wood room temperature circulating water is eluriated 2 times, impregnates 3h with pure water after cleaning, the water surface is higher than above-mentioned raw materials 3cm； Ba Danmu after immersion is crossed 150 mesh filter screens and remove impurity, collect filtrate, dry fruit is made together with soak with colloid mill slurrying Magma is simultaneously spray-dried, and within the scope of dry 130 DEG C of inlet air temperature, within the scope of 70 DEG C of leaving air temp, is crushed, is crossed 600 meshes, take sieve Lower object, obtains fine powder；

Step 5:

After the white garden burnet dried first is crushed to 30 mesh with pulverizer, then with airslide disintegrating mill 600 targeted fine powders are ground into, crushed When drug temperature be lower than 60 DEG C；

Step 6:

The saddle leaf dried, bitter numb dish, dwarf apple are removed into impurity, chopping, after soaking in water 0.5h after mixing, decocted twice, First time amount of water is 6 times of Chinese medicine weight, decocts 1h；Second of amount of water is 5 times of Chinese medicine weight, decocts 0.5h, is merged Decoction liquor twice is concentrated into d=1.05g/ml, and filtering is spray-dried after obtaining Chinese medicine extract, and dry inlet air temperature is set in Within the scope of 130 DEG C, leaving air temp is set within the scope of 70 DEG C, is crushed, and 600 meshes are crossed, and extracting screen underflow obtains fine powder；

Step 7:

The Common Leafflower Herb dried, Chinese sumac are removed into impurity, 6 times of volumes of medicinal material weight are added in chopping, volumetric concentration is 40% Ethyl alcohol, reflux or continuous circumfluence extraction 1 time, each 2h, extracting solution recycles ethyl alcohol, obtains thick paste, is spray-dried, dry inlet air temperature Within the scope of 135 DEG C, within the scope of 75 DEG C of leaving air temp, crushes, cross 600 meshes, extracting screen underflow obtains fine powder；

Step 8:

Step 2 to the obtained several powder of step 7 processing and the nutrition fortifier for smashing it through 600 meshes are put into stirring It is uniformly mixed in machine, blender speed is 50r/min, and mixing time 15min obtains health care mixed powder, using ultraviolet light Sterilizing, ultraviolet wavelength is within the scope of 240nm, and sterilize 28min, carries out dry granulation, graininess intermediate is prepared, in sterile Under the conditions of be packed into capsule；

Step 9:

Comparative example 1:

A kind of capsule with diarrhea-relieving function, capsule contents composition formula are composed of the following raw materials in parts by weight: baobab fruit 600 Part, 600 parts of hill gooseberry, 600 parts of angle melon of thorn, Rosa roxburghii Tratt 500 parts, 500 parts of elaeagnus conferta fruits, 350 parts of Ba Danmu, 120 parts of white garden burnet, horse 120 parts of saddle leaf, bitter numb 100 parts of dish, 100 parts of Common Leafflower Herb, 25 parts of Chinese sumac, 4 parts of nutrition fortifier.

Step 2:

Mature baobab fruit is cleaned into crust, carries out heated-air drying after stripping and slicing, within the scope of 70 DEG C of drying temperature, wind speed 1m/ Baobab fruit after drying is worn into the powder that diameter of particle is 20 μm with biomixer in a manner of vibromill, makes cell wall by s It is broken, it is rapidly cooled within the scope of 25 DEG C, obtains baobab fruit powder, it is spare；

Mature myrtle fruit is removed into handle, gently shower is cleaned with the circulating water of room temperature, and centrifuging and taking juice is stood after mixing evenly 30min crosses 60 mesh filter screens, obtains fruit juice, is concentrated into after relative density is 1.3, vacuum drying, then being ground into partial size is 20 μm of powder End, it is spare；

Step 3:

The resulting fruit juice of above-mentioned processing is spray-dried, dry inlet air temperature is set within the scope of 140 DEG C, and leaving air temp is set It is scheduled within the scope of 80 DEG C, after crushing, crosses 500 meshes, extracting screen underflow obtains powder；

Step 4:

Above-mentioned bar of denier wood room temperature circulating water is eluriated 2 times, impregnates 2h with pure water after cleaning, the water surface is higher than above-mentioned raw materials 4cm； Ba Danmu after immersion is crossed 150 mesh filter screens and remove impurity, collect filtrate, dry fruit is made together with soak with colloid mill slurrying Magma is simultaneously spray-dried, and within the scope of dry 140 DEG C of inlet air temperature, within the scope of 80 DEG C of leaving air temp, is crushed, is crossed 500 meshes, take sieve Lower object, obtains powder；

Step 5:

After the white garden burnet dried first is crushed to 40 mesh with pulverizer, then with airslide disintegrating mill 500 mesh powders are ground into, crushed When drug temperature be lower than 60 DEG C；

Step 6:

The saddle leaf dried, bitter fiber crops dish are removed into impurity, chopping, after soaking in water 0.8h after mixing, decocts twice, adds for the first time Water is 8 times of Chinese medicine weight, decocts 1.2h；Second of amount of water is 6 times of Chinese medicine weight, decocts 0.8h, and merging is decocted twice Boil liquid is concentrated into d=1.1g/ml, and filtering is spray-dried after obtaining Chinese medicine extract, and dry inlet air temperature is set in 140 DEG C of models In enclosing, leaving air temp is set within the scope of 80 DEG C, is crushed, and 500 meshes are crossed, and extracting screen underflow obtains powder；

Step 7:

The Common Leafflower Herb dried, Chinese sumac are removed into impurity, 8 times of volumes of medicinal material weight are added in chopping, volumetric concentration is 50% Ethyl alcohol, reflux or continuous circumfluence extraction 2 times, each 1.5h, extracting solution recycles ethyl alcohol, obtains thick paste, is spray-dried, dry air inlet temperature It spends within the scope of 140 DEG C, within the scope of 80 DEG C of leaving air temp, crushes, cross 500 meshes, extracting screen underflow obtains powder；

Step 8:

Step 2 to the obtained several powder of step 7 processing and the nutrition fortifier for smashing it through 500 meshes are put into stirring It is uniformly mixed in machine, blender speed is 60r/min, and mixing time 13min obtains health care mixed powder, using ultraviolet light Sterilizing, ultraviolet wavelength is within the scope of 220nm, and sterilize 20min, carries out dry granulation, graininess intermediate is prepared, in sterile Under the conditions of be packed into capsule.

Comparative example 2:

A kind of capsule with diarrhea-relieving function, capsule contents composition formula are composed of the following raw materials in parts by weight: baobab fruit 700 Part, 650 parts of hill gooseberry, 650 parts of angle melon of thorn, Rosa roxburghii Tratt 600 parts, 600 parts of elaeagnus conferta fruits, 400 parts of Ba Danmu, 140 parts of white garden burnet, horse 130 parts of saddle leaf, bitter numb 120 parts of dish, 110 parts of dwarf apple, 30 parts of Chinese sumac, 5 parts of nutrition fortifier.

Step 2:

Mature baobab fruit is cleaned into crust, carries out heated-air drying after stripping and slicing, within the scope of 90 DEG C of drying temperature, wind speed is Baobab fruit after drying is worn into the powder that diameter of particle is 30 μm with biomixer in a manner of vibromill, made by 0.5m/s Cell wall is broken, is rapidly cooled within the scope of 30 DEG C, obtains baobab fruit powder, spare；

Mature myrtle fruit is removed into handle, gently shower is cleaned with the circulating water of room temperature, and centrifuging and taking juice is stood after mixing evenly 30min crosses 60 mesh filter screens, obtains fruit juice, is concentrated into after relative density is 1.5, vacuum drying, then being ground into partial size is 30 μm of powder End, it is spare；

Step 3:

Remove thorn after the circulating water of the Rosa roxburghii Tratt room temperature of fresh mature is cleaned, cuts out the seed of the inside, squeezing is put into after stripping and slicing It squeezes the juice in juice machine, crosses 70 mesh filter screens, obtain the sub- fruit juice of Rosa roxburghii Tratt, refrigerate spare；

It by circulating water repeated flushing 4 times of mature elaeagnus conferta fruits room temperature, is put into juice extractor and squeezes the juice after cleaning, cross the filter of 70 mesh Net obtains elaeagnus conferta fruits fruit juice, refrigerates spare；

The resulting fruit juice of above-mentioned processing is spray-dried, dry inlet air temperature is set within the scope of 150 DEG C, and leaving air temp is set It is scheduled within the scope of 90 DEG C, after crushing, crosses 400 meshes, extracting screen underflow obtains powder；

Step 4:

Above-mentioned bar of denier wood room temperature circulating water is eluriated 3 times, impregnates 1h with pure water after cleaning, the water surface is higher than above-mentioned raw materials 5cm； Ba Danmu after immersion is crossed 150 mesh filter screens and remove impurity, collect filtrate, dry fruit is made together with soak with colloid mill slurrying Magma is simultaneously spray-dried, and within the scope of dry 150 DEG C of inlet air temperature, within the scope of 90 DEG C of leaving air temp, is crushed, is crossed 400 meshes, take sieve Lower object, obtains powder；

Step 5:

After the white garden burnet dried first is crushed to 50 mesh with pulverizer, then with airslide disintegrating mill 400 mesh powders are ground into, crushed When drug temperature be lower than 60 DEG C；

Step 6:

The saddle leaf dried, bitter numb dish, dwarf apple are removed into impurity, chopping, after soaking in water 1h after mixing, decocted twice, the Amount of water is 10 times of Chinese medicine weight, decocts 1.4h；Second of amount of water is 7 times of Chinese medicine weight, decocts 1h, merges two Secondary decoction liquor is concentrated into d=1.2g/ml, and filtering is spray-dried after obtaining Chinese medicine extract, and dry inlet air temperature is set in 150 Within the scope of DEG C, leaving air temp is set within the scope of 90 DEG C, is crushed, and 400 meshes are crossed, and extracting screen underflow obtains powder；

Step 7:

The Chinese sumac dried is removed into impurity, chopping is added 10 times of volumes of medicinal material weight, the ethyl alcohol that volumetric concentration is 60%, returns Stream or continuous circumfluence extraction 3 times, each 1h, extracting solution recycles ethyl alcohol, obtains thick paste, is spray-dried, dry 150 DEG C of models of inlet air temperature In enclosing, within the scope of 90 DEG C of leaving air temp, crushes, cross 400 meshes, extracting screen underflow obtains powder；

Step 8:

Step 2 to the obtained several powder of step 7 processing and the nutrition fortifier for smashing it through 500 meshes are put into stirring It is uniformly mixed in machine, blender speed is 70r/min, and mixing time 10min obtains health care mixed powder, using ultraviolet light Sterilizing, ultraviolet wavelength is within the scope of 200nm, and sterilize 20min, carries out dry granulation, graininess intermediate is prepared, in sterile Under the conditions of be packed into capsule.

Comparative example 3:

A kind of capsule with diarrhea-relieving function, capsule contents composition formula are composed of the following raw materials in parts by weight: baobab fruit 550 Part, 500 parts of hill gooseberry, 500 parts of angle melon of thorn, Rosa roxburghii Tratt 450 parts, 400 parts of elaeagnus conferta fruits, 300 parts of Ba Danmu, 110 parts of white garden burnet, horse 100 parts of saddle leaf, bitter numb 90 parts of dish, 90 parts of dwarf apple, 80 parts of Common Leafflower Herb, 3 parts of nutrition fortifier.

Step 2:

Mature baobab fruit is cleaned into crust, carries out heated-air drying after stripping and slicing, within the scope of 50 DEG C of drying temperature, wind speed is Baobab fruit after drying is worn into the powder that diameter of particle is 40 μm with biomixer in a manner of vibromill, made by 1.5m/s Cell wall is broken, is rapidly cooled within the scope of 22 DEG C, obtains baobab fruit powder, spare；

Mature myrtle fruit is removed into handle, gently shower is cleaned with the circulating water of room temperature, and centrifuging and taking juice is stood after mixing evenly 30min crosses 60 mesh filter screens, obtains fruit juice, is concentrated into after relative density is 1.1, vacuum drying, then being ground into partial size is 40 μm of powder End, it is spare；

Step 3:

Remove thorn after the circulating water of the Rosa roxburghii Tratt room temperature of fresh mature is cleaned, cuts out the seed of the inside, squeezing is put into after stripping and slicing It squeezes the juice in juice machine, crosses 60 mesh filter screens, obtain the sub- fruit juice of Rosa roxburghii Tratt, refrigerate spare；

It by circulating water repeated flushing 3 times of mature elaeagnus conferta fruits room temperature, is put into juice extractor and squeezes the juice after cleaning, cross the filter of 60 mesh Net obtains elaeagnus conferta fruits fruit juice, refrigerates spare；

The resulting fruit juice of above-mentioned processing is spray-dried, dry inlet air temperature is set within the scope of 130 DEG C, and leaving air temp is set It is scheduled within the scope of 70 DEG C, after crushing, crosses 300 meshes, extracting screen underflow obtains powder；

Step 4:

Above-mentioned bar of denier wood room temperature circulating water is eluriated 2 times, impregnates 1h with pure water after cleaning, the water surface is higher than above-mentioned raw materials 3cm； Ba Danmu after immersion is crossed 150 mesh filter screens and remove impurity, collect filtrate, dry fruit is made together with soak with colloid mill slurrying Magma is simultaneously spray-dried, and within the scope of dry 130 DEG C of inlet air temperature, within the scope of 75 DEG C of leaving air temp, is crushed, is crossed 300 meshes, take sieve Lower object, obtains powder；

Step 5:

After the white garden burnet dried first is crushed to 30 mesh with pulverizer, then with airslide disintegrating mill 300 mesh powders are ground into, crushed When drug temperature be lower than 60 DEG C；

Step 6:

The saddle leaf dried, bitter numb dish, dwarf apple are removed into impurity, chopping, after soaking in water 0.5h after mixing, decocted twice, First time amount of water is 7 times of Chinese medicine weight, decocts 1h；Second of amount of water is 5 times of Chinese medicine weight, decocts 0.5h, is merged Decoction liquor twice is concentrated into d=1.05g/ml, and filtering is spray-dried after obtaining Chinese medicine extract, and dry inlet air temperature is set in Within the scope of 135 DEG C, leaving air temp is set within the scope of 75 DEG C, is crushed, and 300 meshes are crossed, and extracting screen underflow obtains powder；

Step 7:

The Common Leafflower Herb dried is removed into impurity, chopping is added 6 times of volumes of medicinal material weight, the ethyl alcohol that volumetric concentration is 45%, returns Stream or continuous circumfluence extraction 1 time, each 1h, extracting solution recycles ethyl alcohol, obtains thick paste, is spray-dried, dry 130 DEG C of models of inlet air temperature In enclosing, within the scope of 70 DEG C of leaving air temp, crushes, cross 300 meshes, extracting screen underflow obtains powder；

Step 8:

Step 2 to the obtained several powder of step 7 processing and the nutrition fortifier for smashing it through 500 meshes are put into stirring It is uniformly mixed in machine, blender speed is 50r/min, mixing time 15min, obtains health care mixed powder, carries out dry method system Grain, prepares graininess intermediate, is packed into capsule under aseptic condition.

Effect of the invention is further illustrated below by specific test example.

Test example one: capsule stability provided by the invention is investigated

It (is 60 ± 10% in normal epidemic disaster that capsule made from Examples 1 to 3, comparative example 1~3 is carried out study on the stability respectively Natural lighting under the conditions of test), respectively at 0 month, 6 months, 12 months, 18 months, 24 months sample detections, test result As shown in table 1.

As shown in Table 1, when the capsule that prepared by the embodiment of the present invention 1~3 is placed 24 months under the conditions of room temperature, natural lighting It is normal to still maintain capsule housing, hardness is unchanged, softening phenomenon, it thereby may be ensured that the quality of content is stablized, and compare Wavelength, time is not up to standard or not using works such as ultraviolet disinfection links when capsule prepared by example 1~3 is mainly due to ultraviolet disinfection Skill, therefore capsule housing begins to occur different degrees of softening, until the case where deformation after placing 12 months, illustrates the present invention Examples 1 to 3 preparation capsule stability with higher, leakproofness, it is possible to effectively keep capsule organoleptic indicator and Drug effect.

Test example two: safety testing

(1) acute toxicity test

1. given the test agent: the embodiment of the present invention 1~3 and comparative example 1~3 prepare the health care mixed powder of capsule.

2. experimental animal: choosing healthy mice 60, weight 22g ± 2g, by Dalian Medical Univ's Experimental Animal Center It provides, half male and half female, female mice is to be randomly divided into 6 groups without pregnant state；

3. the magma that intragastric administration on mice is modulated by the health care mixed powder that the present invention prepares capsule, stomach-filling amount is adult dose daily 40 times, to being observed continuously after food 14 days, none animal dead, overall health of patients, diet are taking the photograph water, urine and body weight increase just Often；

4. test result shows: intragastric administration on mice Examples 1 to 3 and comparative example 1~3 prepare the dilute of the health care mixed powder modulation of capsule Paste, stomach-filling amount are 40 times of adult dose daily.It can be seen that the present invention is made by Examples 1 to 3 and comparative example 1~3 Capsule be it is safe, belong to nontoxic grade, edible safety.

(2) long-term toxicity test for animals

2. experimental animal: small white mouse 35, weight 20g ± 2g is provided, male and female by Dalian Medical Univ's Experimental Animal Center Fifty-fifty, female rats are without pregnant state.

3. test method and result: the health care mixed powder that the embodiment of the present invention 1~3 and comparative example 1~3 are prepared capsule is equal Carry out feeding with 40 times of adult dose daily, experimental mouse is randomly divided into 7 groups, wherein 6 groups of difference stomach-filling embodiment of the present invention 1 ~3 and comparative example 1~3 prepare capsule the modulation of health care mixed powder magma, remaining one group of stomach-filling same amount of normal saline；All 7 Group equal continuous gavage 90 days observes animal general toxic reaction and severity, checks each position by operating instruction after execution, and Carry out hematology, the pathological examination of the main organs such as ALT, BUN and the heart, liver, spleen, lung, kidney, stomach.By long-term feeding, 7 groups Rat does not occur toxic reaction, physically well develops, macroscopic appearance and main organs no abnormality seen.Peripheral hemogram and Serum ALT, BUN changes without pathologic compared with the control group；The not significant change such as the pathological replacement heart, liver, spleen, lung, kidney, stomach, therefore, Think through proved by pathology, the embodiment of the present invention 1~3 and comparative example 1~3 prepare the health care mixed powder of capsule to animal without chronic poison Sex expression.

Pass through two above toxicity test, it was demonstrated that the present invention is peace by capsule prepared by Examples 1 to 3 and comparative example 1~3 Complete, belong to nontoxic grade, can normally be eaten by patient.

Test example three, effete test embodiment

1. diarrhea patient 60 (times of defecation is daily more than 3 times) are convened, wherein male 32, women 28, age bracket 21 ~56 years old, average age was 38 years old, was randomly divided into 4 groups, each group gender and in terms of no difference of science of statistics.Embodiment 1 Group, 1 group of comparative example take capsule made from embodiment 1, comparative example 1 respectively, positive controls take certain commercially available brand antidiarrheal agent Changyanling medicine for curing enteritis 3 times a day, is taken before the meal 1 tablet each time, and blank control group injects 0.9% sodium chloride injection, after continuously taking 3 days It is tested.The results are shown in Table 2.

2. therapeutic evaluation:

Cure: diarrhea, colic symptoms disappear, and stool restores normal, and times of defecation restores normal).

Effective: diarrhea, colic symptoms are substantially reduced, and stool is clearly better, and times of defecation is substantially reduced.

Effective: diarrhea, colic symptoms are mitigated, and times of defecation decreases.

Invalid: above-mentioned several symptom of diarrhea change effects are unobvious or aggravated.

Total effective rate=(cure+effective+effectively)/total number of cases × 100%.

As known from Table 2, the capsule that the embodiment of the present invention 1 provides, can significantly cure or alleviate the symptoms such as diarrhea, dysentery, right The total effective rate of diarrhea patient is better than 1 group of comparative example, is also significantly better than blank control group.It can be seen that glue provided by the invention Capsule can be obviously improved diarrhea, the symptom of dysentery.

Test example four: antidiarrheal effect test

2. experimental animal: choosing healthy mice 80, weight 22g ± 2g is mentioned by Dalian Medical Univ's Experimental Animal Center For half male and half female, female mice is to be randomly divided into 8 groups, statistical procedures are comparable without significant difference without pregnant state.

3. treatment method: Examples 1 to 3 group, 1~3 group of comparative example, positive controls and model control group are prohibited before testing Eat 18h, fasting water during test.Examples 1 to 3 is given in stomach-filling respectively, comparative example 1~3 prepares the health care mixed powder of capsule The magma of modulation, the magma that positive controls stomach-filling is modulated by dioctahedral smectite, model control group stomach-filling physiological saline, after 0.5h, often Mouse gavages raw rhubarb decocting liquid (after cold soaking 12h, boiling 10min, be prepared into 25% decocting liquid) by 20mL/kg weight.0.5h Afterwards, each mouse is placed in mouse box and is observed, remove the excrement of mouse discharge, record antidiarrheal time, clinical improvements and the course of disease in time.

4. treatment results: diarrhea mice symptom improves situation, and (stool is normal, be dehydrated, acid poisoning is corrected, and spirit and appetite are good Turn) observation curative effect, as shown in table 3.

Each test group antidiarrheal effect of table 3. compares

Note: compared with model control group, * P < 0.05, * * P < 0.01.

The guarantor of capsule the experimental results showed that, is prepared by 1~3 group of the stomach-filling embodiment of the present invention, 1~3 group of comparative example by table 3 The magma of strong mixed powder modulation, can be obviously shortened the antidiarrheal time of diarrhea mice, clinical improvements effect is obvious.Examples 1 to 3 The effect of group is better than 1~3 group of comparative example, mainly due to material effective component formula, proportion difference and comparative example 1~3 Group effective component additive amount is insufficient, and the granularity prepared in Examples 1 to 3 is finer, is easier to absorb, and 1~3 group of comparative example Not using caused by Ultramicro-powder and fine powder.Wherein, the therapeutic effect of example 1 group is the most significant.

Test example five: diarrhea of mouse test

2. experimental animal: choosing healthy mice 80, weight 22g ± 2g is mentioned by Dalian Medical Univ's Experimental Animal Center For half male and half female, female mice is to be randomly divided into 8 groups without pregnant state.

3. test method: Examples 1 to 3 group, 1~3 group of comparative example, positive controls and model control group are prohibited before testing Eat 18h, fasting water during test.Examples 1 to 3 is given in stomach-filling respectively, comparative example 1~3 prepares the health care mixed powder of capsule The magma of modulation, the magma that positive controls stomach-filling is modulated by dioctahedral smectite, model control group stomach-filling physiological saline, after 0.5h, often Mouse gavages raw rhubarb decocting liquid (after cold soaking 12h, boiling 10min, be prepared into 25% decocting liquid) by 20mL/kg weight.0.5h Afterwards, each mouse is placed in mouse box and is observed, and the excrement of removal mouse discharge, record fill 6h muck number after rheum officinale in time.

Test result is shown in Table 4. diarrhea of mouse test datas

Note: compared with model control group, * P < 0.05, * * P < 0.01.

The guarantor of capsule the experimental results showed that, is prepared by 1~3 group of the stomach-filling embodiment of the present invention, 1~3 group of comparative example by table 4 The magma of strong mixed powder modulation, can significantly reduce the defecation frequency of diarrhea mice, and formed stools degree is good.Examples 1 to 3 group Effect be better than 1~3 group of comparative example, mainly due to material effective component formula, proportion it is different and 1~3 group of comparative example Effective component additive amount is insufficient, and the granularity prepared in Examples 1 to 3 is finer, is easier to absorb, and 1~3 group of comparative example is not Using caused by Ultramicro-powder and fine powder.Wherein, the therapeutic effect of example 1 group is the most significant.

Typical case:

Case 1: seedling * celebrating, male, 31 years old, Dalian Zhuanghe people suffered from acute diarrhea, disease due to having eaten unclean food during the journey Shape: abdominal pain, sometimes Muscular stiffness, stool are in water sample, and daily defecation 5,6 times has collapse to feel, after taken it is of the invention made of glue Capsule, after 1 day, symptom of diarrhea is slowed down, and restores normal after 3 days, after do not recur.

Case 2: square *, female, 39 years old, Jinzhou Dalian people suffered from diarrhea, intestinal colic, and with symptoms of emesis, each feces volume Seldom, excrement is shapeless, but number is up to 3,4 times, and continue for a few days, very painful, after taken it is of the invention made of capsule, The same day there has been effect, and defecation frequency significantly reduces, and has fully recovered after 2 days, has not nowadays also recurred.

The present invention has been explained by the above embodiments, but it is to be understood that, above-described embodiment is only intended to The purpose of citing and explanation, is not intended to limit the invention to the scope of the described embodiments.Furthermore those skilled in the art It is understood that the present invention is not limited to the above embodiments, introduction according to the present invention can also be made more kinds of member Variants and modifications, all fall within the scope of the claimed invention for these variants and modifications.Protection scope of the present invention by The appended claims and its equivalent scope are defined.

Claims

1. a kind of capsule with diarrhea-relieving function, it is characterised in that: its capsule contents composition formula by following parts by weight raw material group At: 500~700 parts of baobab fruit, 500~700 parts of hill gooseberry, thorn 500~700 parts of angle melon, 400~600 parts of Rosa roxburghii Tratt, goat milk 400~600 parts of fruit, 300~400 parts of Ba Danmu, 100~140 parts of white garden burnet, 100~140 parts of saddle leaf, bitter numb dish 80~120 Part, 80~120 parts of dwarf apple, 80~120 parts of Common Leafflower Herb, 20~30 parts of Chinese sumac, 3~5 parts of nutrition fortifier；

Step 2:

Step 3:

Step 4:

Step 5:

Step 6:

Step 7:

Step 8:

Step 2 to the obtained several powder of step 7 processing and the nutrition fortifier for smashing it through 600 meshes are put into stirring It is uniformly mixed in machine, blender speed is 50~70r/min, and mixing time is 10~16min, obtains health care mixed powder, adopts With ultraviolet disinfection, within the scope of 240~280nm, sterilize ultraviolet wavelength 20~30min, carries out dry granulation, prepares Granular intermediate is packed into capsule under aseptic condition；

Step 9:

2. with the capsule of diarrhea-relieving function according to right 1, it is characterised in that: its capsule contents composition formula is by following weight Part raw material composition: 550~650 parts of baobab fruit, 550~650 parts of hill gooseberry, thorn 550~650 parts of angle melon, Rosa roxburghii Tratt 450~ 550 parts, 450~550 parts of elaeagnus conferta fruits, 320~380 parts of Ba Danmu, 110~130 parts of white garden burnet, 110~130 parts of saddle leaf, hardship 90~110 parts of numb dish, 90~110 parts of dwarf apple, 90~110 parts of Common Leafflower Herb, 20~30 parts of Chinese sumac, 4 parts of nutrition fortifier.

3. with the capsule of diarrhea-relieving function according to right 1, it is characterised in that: its capsule contents composition formula is by following weight The raw material composition of part: 600 parts of baobab fruit, 600 parts of hill gooseberry, 600 parts of angle melon of thorn, Rosa roxburghii Tratt 500 parts, elaeagnus conferta fruits 500 part, bar 350 parts of denier wood, 120 parts of white garden burnet, 120 parts of saddle leaf, bitter numb 100 parts of dish, 100 parts of dwarf apple, 100 parts of Common Leafflower Herb, Chinese sumac 25 parts, 4 parts of nutrition fortifier.

4. with the capsule of diarrhea-relieving function according to right 1, it is characterised in that: the nutrition fortifier is amino acid, micro- One or more of secondary element or vitamin；The amino acid is lysine, threonine；The microelement is gluconic acid Zinc, calcium gluconate, ferrous gluconate；The vitamin is vitamin B₁, vitamin B₂Or vitamin C.

5. the production method of the capsule according to right 1 with diarrhea-relieving function, it is characterised in that:, will in above-mentioned steps two Mature baobab fruit cleans crust, carries out heated-air drying after stripping and slicing, and within the scope of 70 DEG C of drying temperature, wind speed 1m/s will be done Baobab fruit after dry wears into the ultra-micro powder that diameter of particle is 7 μm with biomixer in a manner of vibromill, keeps cell wall broken It is broken, it is rapidly cooled within the scope of 25 DEG C, obtains baobab fruit Ultramicro-powder, it is spare；

Mature myrtle fruit is removed into handle, gently shower is cleaned with the circulating water of room temperature, and centrifuging and taking juice is stood after mixing evenly 30min crosses 60 mesh filter screens, obtains fruit juice, is concentrated into after relative density is 1.3, vacuum drying, then being ground into partial size is 7 μm super Micropowder.

6. the production method of the capsule according to right 1 with diarrhea-relieving function, it is characterised in that:, will in above-mentioned steps three After the circulating water of mature thorn angle melon room temperature cleans peeling, by pulp stripping and slicing, it is put into blender and stirs at low speed to separate fruit Meat and seed take its fruit juice after scalping deseeding, and gained are pierced angle melon juice, refrigerate spare；

7. the production method of the capsule according to right 1 with diarrhea-relieving function, it is characterised in that:, will in above-mentioned steps four Above-mentioned bar of denier wood is eluriated 3 times with room temperature circulating water, impregnates 2h with pure water after cleaning, and the water surface is higher than above-mentioned raw materials 4cm；It will impregnate Ba Danmu afterwards is crossed 150 mesh filter screens and removes impurity, collect filtrate, dry fruit magma is made simultaneously together with soak with colloid mill slurrying Spray drying is dried within the scope of 140 DEG C of inlet air temperature, within the scope of 80 DEG C of leaving air temp, is crushed, excessively 700 meshes, extracting screen underflow, Obtain fine powder.

8. the production method of the capsule according to right 1 with diarrhea-relieving function, it is characterised in that:, will in above-mentioned steps five After the white garden burnet dried first is crushed to 40 mesh with pulverizer, then with airslide disintegrating mill it is ground into 700 targeted fine powders, drug when crushing Temperature is lower than 60 DEG C.

9. the production method of the capsule according to right 1 with diarrhea-relieving function, it is characterised in that:, will in above-mentioned steps six Saddle leaf, bitter numb dish, the dwarf apple dried removes impurity, chopping, after soaking in water 0.8h after mixing, decocts twice, for the first time Amount of water is 8 times of Chinese medicine weight, decocts 1.2h；Second of amount of water is 6 times of Chinese medicine weight, decocts 0.8h, is merged twice Decoction liquor is concentrated into d=1.1g/ml, and filtering is spray-dried after obtaining Chinese medicine extract, and dry inlet air temperature is set in 140 DEG C In range, leaving air temp is set within the scope of 80 DEG C, is crushed, and 700 meshes are crossed, and extracting screen underflow obtains fine powder.

10. the production method of the capsule according to right 1 with diarrhea-relieving function, it is characterised in that:, will in above-mentioned steps seven Common Leafflower Herb, the Chinese sumac dried removes impurity, and chopping is added 8 times of volumes of medicinal material weight, the ethyl alcohol that volumetric concentration is 50%, returns Stream or continuous circumfluence extraction 2 times, each 1.5h, extracting solution recycles ethyl alcohol, obtains thick paste, is spray-dried, dry 140 DEG C of inlet air temperature In range, within the scope of 80 DEG C of leaving air temp, crushes, cross 700 meshes, extracting screen underflow obtains fine powder；