CN109394824A

CN109394824A - A kind of anaesthetic of bone-setting pain stopping and preparation method thereof

Info

Publication number: CN109394824A
Application number: CN201811562621.3A
Authority: CN
Inventors: 不公告发明人
Original assignee: AFFILIATED HOSPITAL OF INNER MONGOLIA UNIVERSITY FOR NATIONALITIES
Current assignee: AFFILIATED HOSPITAL OF INNER MONGOLIA UNIVERSITY FOR NATIONALITIES
Priority date: 2018-12-20
Filing date: 2018-12-20
Publication date: 2019-03-01

Abstract

The present invention relates to a kind of drug and production method, i.e., a kind of anaesthetic of bone-setting pain stopping and preparation method thereof.Including bulk pharmaceutical chemicals Cortex Eucommiae, its main feature is that: the Cortex Eucommiae and cupreol, rheum emodin, calcium carbonate, glycine, alanine compatibility, the above-mentioned anaesthetic is prepared from the following raw materials in parts by weight: 18-22 parts of Cortex Eucommiae, 0.5-0.8 part of cupreol, 0.2-0.3 part of rheum emodin, 0.5-1 parts of calcium carbonate, 0.1-0.2 part of glycine, 0.1-0.2 part of alanine.Beneficial effect is: giving full play to the drug effect of Cortex Eucommiae, synthetism, swelling and pain relieving effect substantially enhance, to various fracture caused by wound, the diseases such as dislocation, soft tissue injury are significant in efficacy, and have no toxic side effect, and preparation is simple, it is low in cost, it is expected to the common anaesthetic as set a broken bone.

Description

A kind of anaesthetic of bone-setting pain stopping and preparation method thereof

Technical field

The present invention relates to a kind of drug and production method, i.e., a kind of anaesthetic of bone-setting pain stopping and preparation method thereof.

Background technique

Fracture, is that the continuity of bone structure is broken completely or partially.Its reason mainly has direct, indirect violence, accumulation Property strain etc..When treatment other than the measures such as reset, fixation, functional training, it is necessary to be subject to drug therapy.Common treatment bone The drug of folding is mostly Western medicine and Chinese medicine, and there are also a small number of national drugs.The Mongols is just known as " national on the horse back " from ancient times, because This, Mongolian medicine has novel viewpoint and unique method to the treatment of bone fracture, and forms the anaesthetic proved recipe of many treatment fracture, this A little proved recipes are Ancient Mongolian nationality people labour experience and crystallization of wisdom, are spread always so far, almost without any change, so And the great attention with society to traditional Mongolia Medicine with advances in technology, the study found that there is big in the proved recipe of Mongolian medicine The invalid components or even toxic component of amount, each ingredient mix, and cause anaesthetic dosage big, slowly effective, toxic side effect By force, inconvenient to use, inconvenience storage transport limits the development and utilization of anaesthetic.Preparation method is also mostly that medicinal material fecula is whole It crushes, is all used as medicine, limits the efficiency of drug effective region to play a role.Cortex Eucommiae in anaesthetic is bone-setting pain stopping, treatment The key medicine of bone fracture bone fracture disease, Cortex Eucommiae, the Mongolian great thermal map-treasured of name are eaten " errorless anaesthetic mirror ", and different name reaches cloth monk " recognizing medicine Bai Jingjian ", quick to reach Pine-sharp sketch map-hair in sea all, Cha Gan-hair all " anaesthetic ".It is sweet in flavor from the bark of Eucommiaceae plant Cortex Eucommiae, it is mild-natured.Effect It is greasy, rough, solid, warm, again, it is dry, there is synthetism, heat-clearing effect cures mainly fracture, and bone is warm, tendon lacerated wound etc..And form it is many with Cortex Eucommiae is the anaesthetic prescription of the set a broken bone of monarch drug in a prescription, but in above-mentioned prescription, the taste number of medicine is more, and curative effect is not significant, and compatibility is not true It cuts, is not accurate, non-compatibe drug or ingredient are also mixed into wherein, cause dosage big, and slowly effective, toxic side effect is strong, not housecoat With inconvenience stores the problems such as transporting.

For these reasons, a kind of, significant in efficacy, illiteracy of the bone-setting pain stopping that has no toxic side effect accurate with Cortex Eucommiae compatibility is found Medicine and simple and effective preparation method become Mongolia Medicine worker and compel highly necessary to solve the problems, such as.

Summary of the invention

The purpose of the present invention is find be more suitable for Cortex Eucommiae compatibility, have synthetism, analgesic, detumescence the effect of anaesthetic, and It is significant in efficacy, it has no toxic side effect, the anaesthetic of cheap bone-setting pain stopping.

It is a further object of the present invention to provide the preparation methods of above-mentioned anaesthetic.

Above-mentioned purpose is realized by the following technical solutions: a kind of anaesthetic of bone-setting pain stopping, including bulk pharmaceutical chemicals Cortex Eucommiae are provided, Its main feature is that: the Cortex Eucommiae and cupreol, rheum emodin, calcium carbonate, glycine, alanine compatibility, the above-mentioned anaesthetic by with The bulk pharmaceutical chemicals of lower parts by weight are made: 18-22 parts of Cortex Eucommiae, 0.5-0.8 part of cupreol, and 0.2-0.3 part of rheum emodin, calcium carbonate 0.5-1 parts, 0.1-0.2 part of glycine, 0.1-0.2 part of alanine.

The raw material medicaments in part by weight is added safflower 12-18 parts, 0.5-1.5 parts of borneol.

Described 0.5-0.8 part of cupreol is substituted by 12-18 portions of Radix Notoginseng, and described 0.2-0.3 part of rheum emodin by 4-6 Part rheum officinale substitution, 0.5-1 parts of the calcium carbonate, 0.1-0.2 part of glycine, 0.1-0.2 part of alanine by 4-6 parts of pearls processed Substitution.

0.5-0.8 part of the cupreol is substituted by 10-12 parts of wood of shiny-leaved yellowhorn, 0.2-0.3 part of the rheum emodin by 4-6 parts of rheum officinale substitutions, 0.5-1 parts of the calcium carbonate, 0.1-0.2 part of glycine, 0.1-0.2 part of alanine is made by 4-6 parts Pearl substitution.

Described 0.5-0.8 part of cupreol is substituted by 10-12 parts of the root of straight ladybell, and described 0.2-0.3 part of rheum emodin by 4-6 Part rheum officinale substitution, 0.5-1 parts of the calcium carbonate, 0.1-0.2 part of glycine, 0.1-0.2 part of alanine by 4-6 parts of pearls processed Substitution.

Described 0.5-0.8 part of cupreol is substituted by 12-18 portions of Radix Notoginseng, and described 0.2-0.3 part of rheum emodin by 4- 6 parts of rheum officinale substitutions, 0.5-1 parts of the calcium carbonate, 0.1-0.2 part of glycine, 0.1-0.2 part of alanine by 2-4 parts of keel Substitution.

0.5-0.8 part of the cupreol is substituted by 10-12 parts of wood of shiny-leaved yellowhorn, 0.2-0.3 part of the rheum emodin by 4-6 parts of rheum officinale substitutions, 0.5-1 parts of the calcium carbonate, 0.1-0.2 part of glycine, 0.1-0.2 part of alanine by 2-4 parts of dragons Bone substitution.

Described 0.5-0.8 part of cupreol is substituted by 10-12 parts of the root of straight ladybell, and described 0.2-0.3 part of rheum emodin by 4- 6 rheum officinales substitution, 0.5-1 parts of the calcium carbonate, 0.1-0.2 part of glycine, 0.1-0.2 part of alanine is replaced by 2-4 parts of keel Generation.

The raw material medicaments in part by weight is added 3-5 parts of climbing groundsel, 4-6 parts of blood of goats.

A kind of preparation method of the anaesthetic of the bone-setting pain stopping, it is characterised in that: above-mentioned raw materials medicine is taken by weight, It crushes, sieves with 100 mesh sieve, mix, add water, the water-bindered pill is made.

The preparation method of the anaesthetic of a kind of bone-setting pain stopping, it is characterised in that: take above-mentioned raw materials by the parts by weight Medicine takes Radix Notoginseng, rheum officinale, pearl processed or wood of shiny-leaved yellowhorn, rheum officinale, pearl processed or the root of straight ladybell, rheum officinale, pearl processed or Radix Notoginseng, rheum officinale, dragon Bone or wood of shiny-leaved yellowhorn, rheum officinale, keel or the root of straight ladybell, rheum officinale, keel, are put into ether, are ultrasonically treated 40Min, and filtering discards filter Liquid takes filter residue, is sequentially placed into ethyl acetate, 65% ethyl alcohol, in 80% ethyl alcohol, under the conditions of 40-50 DEG C, is ultrasonically treated respectively 1h, filtering, the filtrate that combined ethyl acetate extraction, 65% ethyl alcohol extraction, 80% ethyl alcohol extract are concentrated filtrate, make liquid content It is 10% -20%, then is mixed with other bulk pharmaceutical chemicals powder, the water-bindered pill is made.

The beneficial effects of the present invention are: giving full play to the drug effect of Cortex Eucommiae, synthetism, swelling and pain relieving effect substantially enhance, externally Various fracture caused by hurting, the diseases such as dislocation, soft tissue injury are significant in efficacy, and have no toxic side effect, and preparation is simple, low in cost, It is expected the common anaesthetic as set a broken bone.

Specific embodiment

The first embodiment: following bulk pharmaceutical chemicals are taken by weight: 18-22 parts of Cortex Eucommiae, 0.5-0.8 part of cupreol, rheum officinale 0.2-0.3 part, 0.5-1 parts of calcium carbonate, 0.1-0.2 part of glycine, 0.1-0.2 part of alanine of element.It is preferred that: 20 parts of Cortex Eucommiae, β- 0.65 part of sitosterol, 0.25 part of rheum emodin, 0.75 part of calcium carbonate, 0.15 part of glycine, 0.15 part of alanine.Take above-mentioned raw materials Medicine, it may be assumed that Cortex Eucommiae, cupreol, rheum emodin, calcium carbonate, glycine, alanine crush, and mix, sieve with 100 mesh sieve, add water, be made The water-bindered pill.

Bulk pharmaceutical chemicals analysis:

Cortex Eucommiae, the Mongolian great thermal map-treasured of name are eaten " errorless anaesthetic mirror ", and different name reaches cloth monk " recognizing medicine Bai Jingjian ", Min Dasong-Hai Lisu Figure-hair all, Cha Gan-hair all " anaesthetic ".From the bark of Eucommiaceae plant Cortex Eucommiae, pharmacological property: it is sweet in flavor, it is mild-natured.Imitate it is greasy, It is rough, solid, warm, again, it is dry.Major function: synthetism, heat-clearing.Cure mainly fracture, bone heat, tendon lacerated wound etc..

Cupreol, English: sitosterol, alias: beta- sitosterol, phytosterol, (3 β)-beans steroid -5- alkene -3- Alcohol, sitosterol, sitosterol, Sitosterolum.Molecular formula C29H50O.Sterol is a kind of substance for having physiological activity, can be promoted for drug Into wound healing, make hypertrophy, enhances capillary circulation.Sitosterol is nontoxic, non-stimulated to skin, has significant anti-inflammatory Function can be used for treating cutaneum carcinoma and skin ulcer, and have norcholesterol, cough-relieving, eliminating the phlegm, the work for inhibiting tumour and repair tissue With.For hypercholesterolemia, atherosclerosis and chronic bronchitis, it to be also used for pre-term cervical cancer and skin ulcer Deng.

Rheum emodin is a kind of orange-yellow long acicular crystal,AcetoneIt is middle crystallization be it is orange, in methanol crystallization be yellow, melt 256 DEG C~257 DEG C of point, the special reaction with anthraquinone, is practically insoluble in water, is dissolved in ethyl alcohol and aqueous slkali.Clinically, with big Flavine pure product treats cancer, is mainly used for the tumours such as leukaemia, gastric cancer, and most common, is used forIt is antibacterial.It is to many bacteriums Such as various staphylococcuses, hemolytic streptococcus, corynebacterium diphtheriae, comma bacillus, Escherichia coli, Pseudomonas aeruginosa, dermatophyte, withered grass The suitable bacillus of bacillus, Mycobacterium graminis, gonococcus, charcoal, grass-like bacterium, typhoid bacillus,Shigella dysenteriaeDeng there is inhibiting effect.It is wherein right Staphylococcus, gonococcus, streptococcus are more effective.This product is also effective to fungi, virus, protozoon.Meanwhile also there is diuresis, benefit Gallbladder, spasmolysis, reduce blood pressure the effects of inhibiting immune function.Almost each section all uses modern age clinic, such as treats encephalitis B and the parotid gland Inflammation, typhoid fever, dysentery, urinary tract infections, stranguria syndrome, pneumonia, cellulitis, suppurative dermatosis, tympanitis, vasculitis etc. and its He treats acute and subacute appendicitis, burn, polio, eczema and several fungus-caused skin infections by compatibility of drugs, In addition hepatitis, pinworm, stomatitis, oral lip's ulcer, indigestion, hypertension and artery sclerosis etc. can be treated, therefore, rheum emodin exists Clinically using extremely wide.

Calcium carbonate, Calcium carbonate, molecular formula: CaCO3.It is a kind of inorganic compound, is commonly called as: lime stone, lime Stone, mountain flour, marble etc..Main component: calcite, chemical formula are CaCO₃, it is in neutrality, is substantially insoluble in, is dissolved in salt Acid.It is Common materials on the earth, is present in the rocks such as aragonite, calcite, chalk, limestone, marble, calcareous tufa, also For the main component of animal skeleton or shell.Precipitated calcium carbonate can be used as leavening agent, Flour ingredient, anticaking agent, acidity adjustment Agent, nutrition fortifier, curing agent etc..China provides the varieties of food items that can be used for that swelling agent need to be added and chewing gum base, presses GMP.It can also be used for flour improver, maximum usage amount is 0.03%；7.5~18g/kg of milk powder；Soymilk powder, 4~20g/ of bean powder kg；0.4~3.4g/kg of soft drink；6~8g/kg of lotus root starch；2~7g/kg of instant breakfast cereal products.FDA(184.1192, 2000) property provides with no restrictions, by GMP.Mostly be used cooperatively with other kinds when this product makees leavening agent use, with sodium bicarbonate, The leavening agent that the compoundings such as alum obtain, heat then slowly release carbon dioxide, and food is made to generate uniform, fine and smooth bulk body, The quality of cake, bread, biscuit can be improved.In addition there are the effect for strengthening calcium, the smaller easier absorptions of calcium carbonate granule.In day This, precipitated calcium carbonate is used as leavening agent, and dosage is 1% in normal food.Can also be used as feed nutrition hardening agent.Calcium carbonate is to cover The main component of medicine calcite has clear bar up to xeothermic, and antiemetic antidiarrheal, helps digestion, detoxifies, the function such as broken ruffian, callus, synthetism tune member Effect.

Glycine, (Glycine, abridge Gly) also known as amion acetic acid, chemical formula C₂H₅NO₂.Solid glycine is The crystal or white crystalline powder of white monoclinic system or hexagonal crystal system, it is odorless, it is nontoxic^[2]；It is readily soluble in water, it is several in ether It is insoluble.

Alanine is the basic unit for constituting protein, is one of the 20 kinds of amino acid for forming human body protein.Its point Minor is C₃H₇NO₂, there is two kinds of isomers of α-alanine and Beta-alanine.Medicinal: prevention kidney stone assists glucose Metabolism helps mitigation hypoglycemia, improves body energy.

Prescription analysis: Cortex Eucommiae, synthetism, heat-clearing cure mainly fracture, and bone heat is monarch drug in a prescription, and minister promotes wound to be cured with cupreol It closes, makes hypertrophy, enhance capillary circulation, calcium carbonate, supplement calcium is helped with rheum emodin, and anti-inflammatory makes with glycine, third Propylhomoserin improves body energy, strengthen immunity, and said medicine complements each other, and synthetism, swelling and pain relieving effect is played altogether, to treat To various fracture caused by wound, each disease such as dislocation, soft tissue injury.

Usage and dosage: with (in addition to auxiliary material) containing main medicine calculation, a 1.0-1.5g, 3 times a day.

With reference to " clinical disease diagnosis is according to the criteria for recovery " (second edition), the medical officer people is published, and edits Sun Chuanxing, knot Feature of the present invention is closed, healing improvement standard of the invention is formulated.

Cure: union, bone function are wholly or substantially restored.

It improves: aligning and be fixed well, wound healing after operation, feeling of pain mitigates.

Invalid: symptom is not any change, and X-ray examination is not any change.

Since 2002, using set a broken bone patient 128 of the present invention, wherein 32 people of Patients with Bone Fracture, fracture of tibia 32 people of patient, 31 people of patellar fracture patient, 33 people of ankle fracture patient, experiment case pass through the attached doctor of National University of the Inner Mongol Institute's diagnosis is made a definite diagnosis, and disease type, number of cases and treatment condition are as follows:

Calculation formula: cure rate=(curing number/sum) × 100%, total effective rate=(sum-invalid number)/sum × 100%。

As it can be seen that being existed using the cure rate of present invention treatment femoral fracture, fracture of tibia, patellar fracture, ankle fracture 56.2% or more, for total effective rate 78.8% or more, average cure rate is 57.8%, and average total effective rate is 80.5%.

Second of embodiment: on the basis of the first embodiment, safflower 12-18 is added in the raw material medicaments in part by weight Part, 0.5-1.5 parts of borneol.That is: safflower 12-18 parts, 0.5-1.5 parts of borneol.That is: Cortex Eucommiae 18-22 parts, cupreol 0.5-0.8 Part, 0.2-0.3 part of rheum emodin, 0.5-1 parts of calcium carbonate, 0.1-0.2 part of glycine, 0.1-0.2 part of alanine, safflower 12-18 Part, 0.5-1.5 parts of borneol.It is preferred that: 20 parts of Cortex Eucommiae, 0.65 part of cupreol, 0.25 part of rheum emodin, 0.65 part of calcium carbonate, sweet ammonia 0.15 part, 0.15 part of alanine, 15 parts of safflower, 1 part of borneol of acid.Take above-mentioned raw materials medicine i.e.: Cortex Eucommiae, cupreol, rheum emodin, carbon Sour calcium, glycine, alanine, safflower, borneol are crushed, are sieved with 100 mesh sieve, and are mixed, are added water, the water-bindered pill is made.

Newly-increased bulk pharmaceutical chemicals analysis:

Safflower, Mongolian name Gu Gu wood, E Ligeneisai mattress.For the dry flower of compositae plant safflower.This product is sweet in flavor, slight bitter, property It is cool, again, it is blunt, soft, solid.The effect of having removing heat from the liver, invigorating blood circulation, relieve pain, menstruation regulating, reduce swelling, nourish positive essence.For hepatomegaly, hepatic injury, Mesh is yellow, and the livers such as liver blood excess heat are newly old to take a disease；Hepatomegaly, liver function are weak.

Borneol, Mongolian name Xi Le-loud, high-pitched sound " recognize medicine Bai Jingjian " within the next few days, and different name looks into dry-loud, high-pitched sound " errorless anaesthetic mirror " within the next few days, and Lip river is all Exhale the honest loud, high-pitched sound of gold-hair within the next few days " anaesthetic ".The native crystal chemical combination being precipitated in the resin of Spore density borneo camphor tree Object.Pharmacological property: bitter, pungent, puckery, cold in nature.It imitates rough, light, blunt, dilute, dynamic, light, soft.Major function: heat-clearing, reduces swelling, analgesic.It cures mainly vehement Heat, epidemic disease heat, old heat, intermal comflict heat are got mildewed in warm conditions, scorchingly hot, erysipelas, toothache, hot eyes, pharyngitis, aphthae.

Prescription analysis: in the first embodiment bulk pharmaceutical chemicals Cortex Eucommiae, cupreol, rheum emodin, calcium carbonate, glycine, the third ammonia On the basis of acid, the effect of safflower enhances promoting blood circulation and stopping pain is added, borneol is added, clear bone heat is reduced swelling, and analgesic further increases Strong above-mentioned prescription synthetism, swelling and pain relieving effect, so as to further treat to various fracture caused by wound, dislocation, Each disease such as soft tissue injury.

Usage and dosage: with (in addition to auxiliary material) containing main medicine calculation, a 1.0-2.0g, 3 times a day.

Cure: union, bone function are wholly or substantially restored.

Invalid: symptom is not any change, and X-ray examination is not any change.

Since 2002, using set a broken bone patient 130 of the present invention, wherein 33 people of Patients with Bone Fracture, fracture of tibia 32 people of patient, 32 people of patellar fracture patient, 33 people of ankle fracture patient, experiment case pass through the attached doctor of National University of the Inner Mongol Institute's diagnosis is made a definite diagnosis, and disease type, number of cases and treatment condition are as follows:

As it can be seen that being existed using the cure rate of present invention treatment femoral fracture, fracture of tibia, patellar fracture, ankle fracture 66.7% or more, for total effective rate 87.9% or more, average cure rate is 69.2%, and average total effective rate is 90.8%.Compared with first The average cure rate of kind embodiment improves 11.4 percentage points, and average total effective rate improves 10.3 percentage points, has received imaginary Less than therapeutic effect.

The third embodiment: on the basis of second of embodiment, 0.5-0.8 part of the cupreol by 12-18 parts of Radix Notoginseng substitutions, described 0.2-0.3 part of rheum emodin is substituted by 4-6 parts of rheum officinales, and 0.5-1 parts of the calcium carbonate is sweet 0.1-0.2 part of propylhomoserin, 0.1-0.2 part of alanine is substituted by 4-6 parts of pearls processed.That is: Cortex Eucommiae 18-22 parts, 12-18 parts of Radix Notoginseng, 4-6 parts of rheum officinale, pearl 4-6 parts processed, 12-18 parts of safflower, 0.5-1.5 parts of borneol.It is preferred that: 20 parts of Cortex Eucommiae, 15 parts of Radix Notoginseng, rheum officinale 5 Part, 5 parts of pearl processed, 15 parts of safflower, 1 part of borneol.

Preparation method one: above-mentioned raw materials medicine is taken by weight, it may be assumed that Cortex Eucommiae, Radix Notoginseng, rheum officinale, pearl processed, safflower, borneol, powder It is broken, it sieves with 100 mesh sieve, adds water, the water-bindered pill is made.

Preparation method two: taking above-mentioned raw materials medicine by the parts by weight, takes Radix Notoginseng, rheum officinale, pearl processed, is put into ether, surpasses Sonication 40Min, filtering, discards filtrate, takes filter residue, is sequentially placed into ethyl acetate, 65% ethyl alcohol, in 80% ethyl alcohol, and 40- Under the conditions of 50 DEG C, it is ultrasonically treated 1h respectively, filters, what combined ethyl acetate extraction, 65% ethyl alcohol extraction, 80% ethyl alcohol extracted Filtrate is concentrated in filtrate, makes liquid content 10% -20%, then mix with other bulk pharmaceutical chemicals (Cortex Eucommiae, safflower, borneol) powder, is made The water-bindered pill.

Usage and dosage: with (in addition to auxiliary material) containing main medicine calculation, a 1.5-2.5g, 3 times a day.

Newly-increased bulk pharmaceutical chemicals analysis:

Radix Notoginseng, Panax Notoginseng also known as pseudo-ginseng, be Umbellales Araliaceae, containing vegetable fat, black pure and mild alkynes, Alkene, hydrocarbon compound.Scientist has got cupreol from Roots of Panax Notoginseng, flower, fruit, has reducing blood lipid and anti-skin ulcer The effects of.From the isolated ene-alkyne hydrocarbon compound-panaxytiol (panaxytriol) of the fatty contents of Roots of Panax Notoginseng, The compound is the aminoacid ingredient in Radix Notoginseng.Its root has the effect of dissipating stasis and stanching bleeding, detumescence ding-tong as medicinal effects. Hemoptysis is cured mainly, haematemesis, bleeding from five sense organs or subcutaneous tissue, hematochezia, metrorrhagia and metrostaxis, traumatic hemorrhage, chest and abdomen shouting pain falls servant's swelling and pain, and has stronger anti-cancer and resist Cancer effect.Currently, being separated to 17 kinds of amino acid in mountain of papers Radix Notoginseng, having 7 kinds is that body body is required, wherein there is a kind of special acid to claim For dencichine (dencichine), there is extraordinary anastalsis.Several rare Chinese medicines of Panax contain hemostatic compositions Dencichine, but with Radix Notoginseng content highest (0.90%), ginseng takes second place (0.50%), and American Ginseng is minimum (0.31%), therefore, Radix Notoginseng Styptic activity is best.

Rheum officinale, RheumpalmatumL, nickname general are the perennial plants of a variety of polygonaceae Rheums, contain Chrysophanol (Chrysophanol), rheum emodin (Emodin), Physcion (Physcion), aloe-emodin (Aloe-emodin), big Yellow acid (Rhein), rheotannic acid (Rheum tannic acids) and its related substances, as gallic acid (Gallic acid), Cachou extract (Cate- chin), tetrarin (Tetrarin), fatty acid, calcium oxalate, glucose, fruit sugar and starch etc..Enter Pharmacological property taste: it is bitter, it trembles with fear.Return stomach meridian, large intestine channel, Liver Channel, the spleen channel, can removing damp-heat, for the jaundice of stagnation of damp-heat, difficult urination, Dry and hard excrement；Also can cooling blood and hemostasis, be used for injury of blood collaterals by heat haematemesis, bleeding from five sense organs or subcutaneous tissue, hematochezia, metrorrhagia and metrostaxis, leukorrhea with reddish discharge.Modern clinic is available It is yellow in treatment epidemic meningitis, lobar pneumonia, acute biliary infection, acute parotidits, acute appendicitis, acute infective Subcutaneous ulcer type hepatitis, chordapsus, bacillary dysentery, hemorrhage of digestive tract, sphagitis, parulis, dermatitis, eczema, stranguria syndrome, band-like blister Rash etc..It fries charcoal and is usually used in cooling blood and hemostasis.

Pearl processed, dairy pearl.Anaesthetic name sweeps Bu De " errorless anaesthetic mirror ", different name male ground lattice.It is dynamic from Pteriidae Shape in the shell-fishes pearl sac such as object pearl shell, Pinctada martensii or Unionidae animal hydriopsis cumingii, anodonta woodiana pacifica, cristaria plicata At without nucleus pearl.The pearl of pearl shell mainly contains calcium carbonate 92%, organic matter about 5%, metallic element have aluminium, copper, iron, magnesium, Manganese, sodium, zinc, silicon, titanium etc..Still containing amino acid such as histidine, arginine, threonine, serines.The pearl of Pinctada martensii contains There are 16 kinds of inorganic elements, based on calcium carbonate, secondary is the compound of silicon, sodium, magnesium, and keratin contains 16 kinds of amino acid, with the third ammonia The content of acid and glycine is higher, and secondary is aspartic acid, leucine and arginine, still contains taurine.The pearl of triangle freshwater mussel, which breathes out, to be had 20 kinds of inorganic elements, highest content is calcium, is secondly sodium, is additionally rich in amino acid, wherein glycine and alanine content Higher, threonine content is very low.20 kinds of inorganic elements such as the pearl calcic of cristaria plicata, sodium, magnesium, strontium, iron, manganese and carbonate, Oxalic acid is with equal acid radical anions, containing 15 kinds or more of amino acid, wherein secondary is asparagus fern with the content highest of glycine, alanine Propylhomoserin, serine, leucine.The effects of pharmacological action: delaying senescence, anti-oxidant, antitumor.Process: dairy pearl takes treasure Pearl, size is separated, and big person is pounded into fritter, merged with small person, sets and boils 4-6h in milk or ewe's milk, takes out, dry.Pharmacological property: taste It is bitter, salty, it is mild-natured.Major function: removing toxic substances, calmness, feeding brain, more arteries and veins.Cure mainly toxication, encephalomyelopathy, apoplexy, white vein, gout, trip pain Disease, sore.

Prescription analysis: experiment is selected by a large amount of bulk pharmaceutical chemicals, the cupreol is substituted by Radix Notoginseng, the rheum officinale Element is substituted by rheum officinale, the calcium carbonate, glycine, and alanine is substituted by pearl processed, and will in the preparation method of optimization Radix Notoginseng, rheum officinale, pearl processed are extracted, under the premise of finding with the accurate compatibility of Cortex Eucommiae, in the base for guaranteeing drug effect On plinth, drug cost is further decreased.

Preparation method analysis: Radix Notoginseng, rheum officinale, pearl processed are first removed into partial invalidity ingredient with ether, using acetic acid respectively Ethyl ester, 65% ethyl alcohol, 80% ethyl alcohol extract active component, this processing method, relatively only with Radix Notoginseng, rheum officinale, pearl raw material processed Medicine further increases the accuracy with Cortex Eucommiae compatibility, then water-bindered pill agent processed is mixed with other drugs, and the purpose is to guarantee drug effect On the basis of, further decrease drug cost.Also ingredient confirms that this is theoretical to experimental result, under equal conditions, using second The therapeutic effect that kind preparation method obtains is higher than the first preparation method, and cure rate, effective percentage, which have, averagely improves 2-4 Percentage point.Preferably second of preparation method, experiment content and data are as follows below.

Cure: union, bone function are wholly or substantially restored.

Invalid: symptom is not any change, and X-ray examination is not any change.

Since 2002, using set a broken bone patient 128 of the present invention, wherein 32 people of Patients with Bone Fracture, fracture of tibia 32 people of patient, 32 people of patellar fracture patient, 32 people of ankle fracture patient, experiment case pass through the attached doctor of National University of the Inner Mongol Institute's diagnosis is made a definite diagnosis, and disease type, number of cases and treatment condition are as follows:

As it can be seen that being existed using the cure rate of present invention treatment femoral fracture, fracture of tibia, patellar fracture, ankle fracture 62.5% or more, for total effective rate 84.3% or more, average cure rate is 63.3%, and average total effective rate is 87.5%.Averagely control More rate reduces by 5.9 percentage points compared with second of embodiment, and average total effective rate reduces by 3.3 percentage points compared with second of embodiment. Therapeutic effect has no significant change, and therefore, above-mentioned raw materials medicine can be used as substitute, to reduce the cost of drug, expands medicine The scope of application of object has wide prospect of the application especially to basic hospital.

In addition, follow-up investigation, drug does not generate any toxic side effect to patient.

4th kind of embodiment: on the basis of second of embodiment, described 0.5-0.8 part of cupreol by 10-12 parts Wood of shiny-leaved yellowhorn substitution, described 0.2-0.3 part of rheum emodin is substituted by 4-6 parts of rheum officinales, 0.5-1 parts of the calcium carbonate, glycine 0.1-0.2 part, 0.1-0.2 part of alanine is substituted by 4-6 parts of pearls processed.That is: Cortex Eucommiae 18-22 parts, 10-12 parts of wood of shiny-leaved yellowhorn, greatly It is 4-6 parts yellow, pearl 4-6 parts processed, 12-18 parts of safflower, 0.5-1.5 parts of borneol.It is preferred that: 20 parts of Cortex Eucommiae, 11 parts of wood of shiny-leaved yellowhorn, rheum officinale 5 Part, 5 parts of pearl processed, 15 parts of safflower, 1 part of borneol.

Preparation method one: above-mentioned raw materials medicine is taken by weight, it may be assumed that Cortex Eucommiae, wood of shiny-leaved yellowhorn, rheum officinale, pearl processed, safflower, borneol, It crushes, sieves with 100 mesh sieve, add water, the water-bindered pill is made.

Preparation method two: taking above-mentioned raw materials medicine by the parts by weight, takes wood of shiny-leaved yellowhorn, rheum officinale, pearl processed, is put into ether, It is ultrasonically treated 40Min, filtering discards filtrate, takes filter residue, it is sequentially placed into ethyl acetate, 65% ethyl alcohol, in 80% ethyl alcohol, Under the conditions of 40-50 DEG C, it is ultrasonically treated 1h respectively, filters, combined ethyl acetate extraction, 65% ethyl alcohol extraction, 80% ethyl alcohol mention Filtrate is concentrated in the filtrate taken, makes liquid content 10% -20%, then mix with other bulk pharmaceutical chemicals (Cortex Eucommiae, safflower, borneol) powder, The water-bindered pill is made.

Newly-increased bulk pharmaceutical chemicals analysis:

Wood of shiny-leaved yellowhorn, Mongolian name monk steps on, the rich heat of He E mattress Tao Laiyin-, Ge Reletuji wood this, Xi La-monk steps on.For no trouble The dry duramen of scarabaeidae plant shiny-leaved yellowhorn (Xanthoccerassorbifolia Bunge).This product is sweet in flavor, puckery, slight bitter, cool in nature, It is dry, puckery, floating, light.There is the effect of dry yellow water, heat-clearing, detumescence, analgesic.For joint pain, dyskinesia, the Huangs such as pruitus Water spreads disease and heart grasserie etc..In wood of shiny-leaved yellowhorn containing rheum emodin, Physcion, cupreol, stigmasterol, Chrysophanol, The ingredients such as Quercetin.

Prescription analysis: experiment is selected by a large amount of bulk pharmaceutical chemicals, the cupreol is substituted by wood of shiny-leaved yellowhorn, and described is big Flavine is substituted by rheum officinale, the calcium carbonate, glycine, and alanine is substituted by pearl processed, and in the preparation method of optimization Wood of shiny-leaved yellowhorn, rheum officinale, pearl processed are extracted, under the premise of finding with the accurate compatibility of Cortex Eucommiae, guaranteeing drug effect On the basis of, further decrease drug cost.

Preparation method analysis: wood of shiny-leaved yellowhorn, rheum officinale, pearl processed are first removed into partial invalidity ingredient with ether, using second respectively Acetoacetic ester, 65% ethyl alcohol, 80% ethyl alcohol extract active component, this processing method, relatively only with wood of shiny-leaved yellowhorn, rheum officinale, pearl processed Bulk pharmaceutical chemicals further increase the accuracy with Cortex Eucommiae compatibility, then water-bindered pill agent processed is mixed with other drugs, and the purpose is to guarantee On the basis of drug effect, drug cost is further decreased.Also ingredient confirms that this is theoretical to experimental result, under equal conditions, uses The therapeutic effect that second of preparation method obtains is higher than the first preparation method, and cure rate, effective percentage, which have, averagely to be improved 3-4 percentage points.Preferably second of preparation method, experiment content and data are as follows below.

Cure: union, bone function are wholly or substantially restored.

Invalid: symptom is not any change, and X-ray examination is not any change.

Since 2006, using set a broken bone patient 130 of the present invention, wherein 33 people of Patients with Bone Fracture, fracture of tibia 32 people of patient, 32 people of patellar fracture patient, 33 people of ankle fracture patient, experiment case pass through the attached doctor of National University of the Inner Mongol Institute's diagnosis is made a definite diagnosis, and disease type, number of cases and treatment condition are as follows:

As it can be seen that being existed using the cure rate of present invention treatment femoral fracture, fracture of tibia, patellar fracture, ankle fracture 62.5% or more, for total effective rate 84.3% or more, average cure rate is 63.8%, and average total effective rate is 86.9%.Averagely control More rate reduces by 5.4 percentage points compared with second of embodiment, and average total effective rate reduces by 3.9 percentage points compared with second of embodiment. Therapeutic effect has no significant change, and therefore, above-mentioned raw materials medicine can be used as substitute, to reduce the cost of drug, expands medicine The scope of application of object has wide prospect of the application especially to basic hospital.

5th kind of embodiment: on the basis of second of embodiment, described 0.5-0.8 part of cupreol by 10-12 parts The root of straight ladybell substitution, described 0.2-0.3 part of rheum emodin is substituted by 4-6 parts of rheum officinales, 0.5-1 parts of the calcium carbonate, glycine 0.1-0.2 part, 0.1-0.2 part of alanine is substituted by 4-6 parts of pearls processed.That is: Cortex Eucommiae 18-22 parts, 10-12 parts of the root of straight ladybell, rheum officinale 4-6 parts, pearl 4-6 parts processed, 12-18 parts of safflower, 0.5-1.5 parts of borneol.It is preferred that: 20 parts of Cortex Eucommiae, 11 parts of the root of straight ladybell, 5 parts of rheum officinale, system 5 parts of pearl, 15 parts of safflower, 1 part of borneol.

Preparation method one: above-mentioned raw materials medicine is taken by weight, it may be assumed that Cortex Eucommiae, the root of straight ladybell, rheum officinale, pearl processed, safflower, borneol, powder It is broken, it sieves with 100 mesh sieve, adds water, the water-bindered pill is made.

Preparation method two: taking above-mentioned raw materials medicine by the parts by weight, takes the root of straight ladybell, rheum officinale, pearl processed, is put into ether, surpasses Sonication 40Min, filtering, discards filtrate, takes filter residue, is sequentially placed into ethyl acetate, 65% ethyl alcohol, in 80% ethyl alcohol, and 40- Under the conditions of 50 DEG C, it is ultrasonically treated 1h respectively, filters, what combined ethyl acetate extraction, 65% ethyl alcohol extraction, 80% ethyl alcohol extracted Filtrate is concentrated in filtrate, makes liquid content 10% -20%, then mix with other bulk pharmaceutical chemicals (Cortex Eucommiae, safflower, borneol) powder, is made The water-bindered pill.

Newly-increased bulk pharmaceutical chemicals analysis:

The root of straight ladybell, Adenophora stricta alias: adenophora tetraphylla, bubble ginseng, bubble the root of straight ladybell.According to relevant information, in the root of adenophora tetraphylla Root containing triterpenoid saponin and starch glehnia littoralis contains alkaloid, starch abundant；Fruit (Phellopterin) containing phellopterin, And analyse osthole (Imperatorin), bergapten (Bergapten), the root of various Lady bell medicinal plants are fat-soluble Contain palmityl cupreol, lupenone, cupreol and 24- methylene-cycloartanol the root of straight ladybell taste in ingredient It is sweet;Slight bitter;Cold nature;Return lung;Stomach meridian.Can clearing heat and nourishing yin, moistening lung to arrest cough has eliminating the phlegm, heart tonifying, antipyretic, analgesia, antimycotic etc. Effect is usually used in treating tracheitis, pertussis, cough with lung heat, cough up phlegm yellow thick.

Prescription analysis: experiment is selected by a large amount of bulk pharmaceutical chemicals, the cupreol is substituted by the root of straight ladybell, the rheum officinale Element is substituted by rheum officinale, the calcium carbonate, glycine, and alanine is substituted by pearl processed, and will in the preparation method of optimization The root of straight ladybell, rheum officinale, pearl processed are extracted, under the premise of finding with the accurate compatibility of Cortex Eucommiae, in the base for guaranteeing drug effect On plinth, drug cost is further decreased.

Preparation method analysis: the root of straight ladybell, rheum officinale, pearl processed are first removed into partial invalidity ingredient with ether, using acetic acid respectively Ethyl ester, 65% ethyl alcohol, 80% ethyl alcohol extract active component, this processing method, relatively only with the root of straight ladybell, rheum officinale, pearl raw material processed Medicine further increases the accuracy with Cortex Eucommiae compatibility, then water-bindered pill agent processed is mixed with other drugs, and the purpose is to guarantee drug effect On the basis of, further decrease drug cost.Also ingredient confirms that this is theoretical to experimental result, under equal conditions, using second The therapeutic effect that kind preparation method obtains is higher than the first preparation method, and cure rate, effective percentage, which have, averagely improves 2-4 Percentage point.Preferably second of preparation method, experiment content and data are as follows below.

Cure: union, bone function are wholly or substantially restored.

Invalid: symptom is not any change, and X-ray examination is not any change.

Since 2007, using set a broken bone patient 131 of the present invention, wherein 32 people of Patients with Bone Fracture, fracture of tibia 34 people of patient, 32 people of patellar fracture patient, 33 people of ankle fracture patient, experiment case pass through the attached doctor of National University of the Inner Mongol Institute's diagnosis is made a definite diagnosis, and disease type, number of cases and treatment condition are as follows:

As it can be seen that being existed using the cure rate of present invention treatment femoral fracture, fracture of tibia, patellar fracture, ankle fracture 59.3% or more, for total effective rate 84.3% or more, average cure rate is 62.3%, and average total effective rate is 88.5%.Averagely control More rate reduces by 6.9 percentage points compared with second of embodiment, and average total effective rate reduces by 2.3 percentage points compared with second of embodiment. Therapeutic effect has no too big variation, and therefore, above-mentioned raw materials medicine can be used as substitute, to reduce the cost of drug, expands medicine The scope of application of object has wide prospect of the application especially to basic hospital.

6th kind of embodiment: on the basis of second of embodiment, described 0.5-0.8 part of cupreol by 12-18 parts Radix Notoginseng substitution, described 0.2-0.3 part of rheum emodin is substituted by 4-6 parts of rheum officinales, 0.5-1 parts of the calcium carbonate, glycine 0.1-0.2 part, 0.1-0.2 part of alanine is substituted by 2-4 parts of keel.That is: Cortex Eucommiae 18-22 parts, 12-18 parts of Radix Notoginseng, rheum officinale 4-6 Part, 2-4 parts of keel, 12-18 parts of safflower, 0.5-1.5 parts of borneol.It is preferred that: 20 parts of Cortex Eucommiae, 15 parts of Radix Notoginseng, 5 parts of rheum officinale, keel 3 Part, 15 parts of safflower, 1 part of borneol.

Preparation method one: above-mentioned raw materials medicine is taken by weight, it may be assumed that Cortex Eucommiae, Radix Notoginseng, rheum officinale, keel, safflower, borneol, powder It is broken, it sieves with 100 mesh sieve, adds water, the water-bindered pill is made.

Production method two: taking above-mentioned raw materials medicine by the parts by weight, take Radix Notoginseng, rheum officinale, keel, be put into ether, ultrasound 40Min is handled, filtering discards filtrate, takes filter residue, it is sequentially placed into ethyl acetate, 65% ethyl alcohol, in 80% ethyl alcohol, 40-50 Under the conditions of DEG C, it is ultrasonically treated 1h respectively, filters, the filter that combined ethyl acetate extraction, 65% ethyl alcohol extraction, 80% ethyl alcohol extract Filtrate is concentrated in liquid, makes liquid content 10% -20%, then mix with other bulk pharmaceutical chemicals (Cortex Eucommiae, safflower, borneol) powder, water is made Ball.

Newly-increased bulk pharmaceutical chemicals analysis:

Keel, Mongolian name Lu-Ya Si, different name cloth such as lattice are auspicious, alias: Lu Hu loses life, that gal bone, Os Draconis, calcined Dragon's bone, five Hua Long Bone, bluenessization keel, OS DRACONIS, white keel.For ancient times mammal as if the fossil of the skeleton of class, rhinoceros class, Hippocampal cortex etc..Change It studies point: main hydroxyl calcium phosphate Ca5(PO4) 3(OH) (hydroxyapatite)；Still contain a small amount of calcium carbonate and iron, aluminium, magnesium, manganese, strontium etc. Element.Pharmacological property: sweet in flavor, puckery, mild-natured, major function: killing viscous, only shouting pain, only rotten, myogenic holds back wound and calms the nerves.

Prescription analysis: experiment is selected by a large amount of bulk pharmaceutical chemicals, the cupreol is substituted by Radix Notoginseng, the rheum officinale Element is substituted by rheum officinale, the calcium carbonate, glycine, and alanine is substituted by keel.And by three in the preparation method of optimization Seven, rheum officinale, keel are extracted, under the premise of finding with the accurate compatibility of Cortex Eucommiae, on the basis of guaranteeing drug effect, Further decrease drug cost.

Preparation method analysis: Radix Notoginseng, rheum officinale, keel are first removed into partial invalidity ingredient with ether, are using acetic acid second respectively Ester, 65% ethyl alcohol, 80% ethyl alcohol extract active component, this processing method, more only with Radix Notoginseng, rheum officinale, keel bulk pharmaceutical chemicals into One step increases the accuracy with Cortex Eucommiae compatibility, then water-bindered pill agent processed is mixed with other drugs, and the purpose is in the base for guaranteeing drug effect On plinth, drug cost is further decreased.Also ingredient confirms that this is theoretical to experimental result, under equal conditions, is made using second The therapeutic effect that Preparation Method obtains is higher than the first preparation method, and cure rate, effective percentage, which have, averagely improves 2-4 percentage Point.Preferably second of preparation method, experiment content and data are as follows below.

Cure: union, bone function are wholly or substantially restored.

Invalid: symptom is not any change, and X-ray examination is not any change.

Since 2008, using set a broken bone patient 133 of the present invention, wherein 33 people of Patients with Bone Fracture, fracture of tibia 33 people of patient, 34 people of patellar fracture patient, 33 people of ankle fracture patient, experiment case pass through the attached doctor of National University of the Inner Mongol Institute's diagnosis is made a definite diagnosis, and disease type, number of cases and treatment condition are as follows:

As it can be seen that being existed using the cure rate of present invention treatment femoral fracture, fracture of tibia, patellar fracture, ankle fracture 61.8% or more, for total effective rate 85.3% or more, average cure rate is 64.7%, and average total effective rate is 88.0%.Averagely control More rate reduces by 4.5 percentage points compared with second of embodiment, and average total effective rate reduces by 2.8 percentage points compared with second of embodiment. Therapeutic effect has no too big variation, and therefore, above-mentioned raw materials medicine can be used as substitute, to reduce the cost of drug, expands medicine The scope of application of object has wide prospect of the application especially to basic hospital.

7th kind of embodiment: on the basis of second of embodiment, described 0.5-0.8 part of cupreol by 10-12 parts Wood of shiny-leaved yellowhorn substitution, described 0.2-0.3 part of rheum emodin is substituted by 4-6 parts of rheum officinales, 0.5-1 parts of the calcium carbonate, glycine 0.1-0.2 part, 0.1-0.2 part of alanine is substituted by 2-4 parts of keel.That is: Cortex Eucommiae 18-22 parts, 10-12 parts of wood of shiny-leaved yellowhorn, rheum officinale 4-6 parts, 2-4 parts of keel, 12-18 parts of safflower, 0.5-1.5 parts of borneol.It is preferred that: 20 parts of Cortex Eucommiae, 11 parts of wood of shiny-leaved yellowhorn, 5 parts of rheum officinale, dragon 3 parts of bone, 15 parts of safflower, 1 part of borneol.

Preparation method one: above-mentioned raw materials medicine is taken by weight, it may be assumed that Cortex Eucommiae, wood of shiny-leaved yellowhorn, rheum officinale, keel, safflower, borneol, powder It is broken, it sieves with 100 mesh sieve, adds water, the water-bindered pill is made.

Preparation method two: taking above-mentioned raw materials medicine by the parts by weight, and wood of shiny-leaved yellowhorn, rheum officinale, keel are put into ether, ultrasound 40Min is handled, filtering discards filtrate, takes filter residue, it is sequentially placed into ethyl acetate, 65% ethyl alcohol, in 80% ethyl alcohol, 40-50 Under the conditions of DEG C, it is ultrasonically treated 1h respectively, filters, the filter that combined ethyl acetate extraction, 65% ethyl alcohol extraction, 80% ethyl alcohol extract Filtrate is concentrated in liquid, makes liquid content 10% -20%, then mix with other bulk pharmaceutical chemicals (Cortex Eucommiae, safflower, borneol) powder, water is made Ball.

Prescription analysis: experiment is selected by a large amount of bulk pharmaceutical chemicals, the cupreol is substituted by wood of shiny-leaved yellowhorn, and described is big Flavine is substituted by rheum officinale, the calcium carbonate, glycine, and alanine is substituted by keel.And it will in the preparation method of optimization Wood of shiny-leaved yellowhorn, rheum officinale, keel are extracted, under the premise of finding with the accurate compatibility of Cortex Eucommiae, in the base for guaranteeing drug effect On plinth, drug cost is further decreased.

Preparation method analysis: wood of shiny-leaved yellowhorn, rheum officinale, keel are first removed into partial invalidity ingredient with ether, are using acetic acid respectively Ethyl ester, 65% ethyl alcohol, 80% ethyl alcohol extract active component, and this processing method more only uses wood of shiny-leaved yellowhorn, rheum officinale, keel raw material Medicine further increases the accuracy with Cortex Eucommiae compatibility, then water-bindered pill agent processed is mixed with other drugs, and the purpose is to guarantee drug effect On the basis of, further decrease drug cost.Also ingredient confirms that this is theoretical to experimental result, under equal conditions, using second The therapeutic effect that kind preparation method obtains is higher than the first preparation method, and cure rate, effective percentage, which have, averagely improves 2-3 Percentage point.Preferably second of preparation method, experiment content and data are as follows below.

Cure: union, bone function are wholly or substantially restored.

Invalid: symptom is not any change, and X-ray examination is not any change.

Since 2010, using set a broken bone patient 130 of the present invention, wherein 33 people of Patients with Bone Fracture, fracture of tibia 32 people of patient, 32 people of patellar fracture patient, 33 people of ankle fracture patient, experiment case pass through the attached doctor of National University of the Inner Mongol Institute's diagnosis is made a definite diagnosis, and disease type, number of cases and treatment condition are as follows:

As it can be seen that being existed using the cure rate of present invention treatment femoral fracture, fracture of tibia, patellar fracture, ankle fracture 57.6% or more, for total effective rate 84.8% or more, average cure rate is 63.1%, and average total effective rate is 87.7%.Averagely control More rate reduces by 6.1 percentage points compared with second of embodiment, and average total effective rate reduces by 3.1 percentage points compared with second of embodiment. Therapeutic effect has no significant change, and therefore, above-mentioned raw materials medicine can be used as substitute, to reduce the cost of drug, expands medicine The scope of application of object has wide prospect of the application especially to basic hospital.

8th kind of embodiment: on the basis of second of embodiment, described 0.5-0.8 part of cupreol by 10-12 parts The root of straight ladybell substitution, described 0.2-0.3 part of rheum emodin is substituted by 4-6 rheum officinales, 0.5-1 parts of the calcium carbonate, glycine 0.1- 0.2 part, 0.1-0.2 part of alanine is substituted by 2-4 parts of keel.That is: Cortex Eucommiae 18-22 parts, 10-12 parts of the root of straight ladybell, 4-6 parts of rheum officinale, dragon 2-4 parts of bone, 12-18 parts of safflower, 0.5-1.5 parts of borneol.It is preferred that: 20 parts of Cortex Eucommiae, 11 parts of the root of straight ladybell, 5 parts of rheum officinale, 3 parts of keel, safflower 15 parts, 1 part of borneol.

Preparation method one: above-mentioned raw materials medicine is taken by weight, it may be assumed that Cortex Eucommiae, the root of straight ladybell, rheum officinale, keel, safflower, borneol, powder It is broken, it sieves with 100 mesh sieve, adds water, the water-bindered pill is made.

Preparation method two: taking above-mentioned raw materials medicine by the parts by weight, take the root of straight ladybell, rheum officinale, keel, be put into ether, ultrasound 40Min is handled, filtering discards filtrate, takes filter residue, it is sequentially placed into ethyl acetate, 65% ethyl alcohol, in 80% ethyl alcohol, 40-50 Under the conditions of DEG C, it is ultrasonically treated 1h respectively, filters, the filter that combined ethyl acetate extraction, 65% ethyl alcohol extraction, 80% ethyl alcohol extract Filtrate is concentrated in liquid, makes liquid content 10% -20%, then mix with other bulk pharmaceutical chemicals (Cortex Eucommiae, safflower, borneol) powder, water is made Ball.

Prescription analysis: experiment is selected by a large amount of bulk pharmaceutical chemicals, the cupreol is substituted by the root of straight ladybell, the rheum officinale Element is substituted by rheum officinale, the calcium carbonate, glycine, and alanine is substituted by keel.And it will be husky in the preparation method of optimization Ginseng, rheum officinale, keel are extracted, under the premise of finding with the accurate compatibility of Cortex Eucommiae, on the basis of guaranteeing drug effect, Further decrease drug cost.

Preparation method analysis: the root of straight ladybell, rheum officinale, keel are first removed into partial invalidity ingredient with ether, are using acetic acid second respectively Ester, 65% ethyl alcohol, 80% ethyl alcohol extract active component, this processing method, more only with the root of straight ladybell, rheum officinale, keel bulk pharmaceutical chemicals into One step increases the accuracy with Cortex Eucommiae compatibility, then water-bindered pill agent processed is mixed with other drugs, and the purpose is in the base for guaranteeing drug effect On plinth, drug cost is further decreased.Also ingredient confirms that this is theoretical to experimental result, under equal conditions, is made using second The therapeutic effect that Preparation Method obtains is higher than the first preparation method, and cure rate, effective percentage, which have, averagely improves 2-4 percentage Point.Preferably second of preparation method, experiment content and data are as follows below.

Cure: union, bone function are wholly or substantially restored.

Invalid: symptom is not any change, and X-ray examination is not any change.

Since 2011, using set a broken bone patient 131 of the present invention, wherein 33 people of Patients with Bone Fracture, fracture of tibia 33 people of patient, 32 people of patellar fracture patient, 33 people of ankle fracture patient, experiment case pass through the attached doctor of National University of the Inner Mongol Institute's diagnosis is made a definite diagnosis, and disease type, number of cases and treatment condition are as follows: experiment case and pass through Affiliated Hospital of Inner Mongolia University for the Nationalities Diagnosis is made a definite diagnosis, and disease type, number of cases and treatment condition are as follows:

As it can be seen that being existed using the cure rate of present invention treatment femoral fracture, fracture of tibia, patellar fracture, ankle fracture 60.6% or more, for total effective rate 84.8% or more, average cure rate is 64.1%, and average total effective rate is 90.1%.Averagely control More rate reduces by 5.1 percentage points compared with second of embodiment, and average total effective rate reduces by 0.7 percentage point compared with second of embodiment. Therapeutic effect has no significant change, and therefore, above-mentioned raw materials medicine can be used as substitute, to reduce the cost of drug, expands medicine The scope of application of object has wide prospect of the application especially to basic hospital.

9th kind of embodiment: on the basis of the 8th kind of embodiment, the raw material medicaments in part by weight adds 3-5 parts of climbing groundsel, 4-6 parts of blood of goats.That is: Cortex Eucommiae 18-22 parts, 10-12 parts of the root of straight ladybell, 4-6 parts of rheum officinale, 2-4 parts of keel, 12-18 parts of safflower, borneol 0.5-1.5 parts, 3-5 parts of climbing groundsel, 4-6 parts of blood of goats.It is preferred that: it is 20 parts of Cortex Eucommiae, 11 parts of the root of straight ladybell, 5 parts of rheum officinale, 3 parts of keel, red Spend 15 parts, 1 part of borneol, 4 parts of climbing groundsel, 5 parts of blood of goats.

Preparation method one: above-mentioned raw materials medicine is taken by weight, it may be assumed that Cortex Eucommiae, the root of straight ladybell, rheum officinale, keel, safflower, borneol, a thousand li Light, blood of goats crush, sieve with 100 mesh sieve, add water, the water-bindered pill is made.

Preparation method two: taking above-mentioned raw materials medicine by the parts by weight, take the root of straight ladybell, rheum officinale, keel, be put into ether, ultrasound 40Min is handled, filtering discards filtrate, takes filter residue, it is sequentially placed into ethyl acetate, 65% ethyl alcohol, in 80% ethyl alcohol, 40-50 Under the conditions of DEG C, it is ultrasonically treated 1h respectively, filters, the filter that combined ethyl acetate extraction, 65% ethyl alcohol extraction, 80% ethyl alcohol extract Liquid is concentrated filtrate, makes liquid content 10% -20%, then with other bulk pharmaceutical chemicals (Cortex Eucommiae, safflower, borneol, climbing groundsel, blood of goats) powder End mixes, and the water-bindered pill is made.

Usage and dosage: with (in addition to auxiliary material) containing main medicine calculation, a 1.5-3.0g, 3 times a day.

Newly-increased bulk pharmaceutical chemicals analysis:

Climbing groundsel, Mongolian name Ge Qi is to slow, and different name Gu is auspicious, ancient auspicious mamba " errorless anaesthetic mirror ", the clear conspicuous door of Wu Douli lattice-, Wu Dou Power lattice-are black odd to slow " anaesthetic ".For the wounded in the battle aerial part of compositae plant Senecio argunensis.Pharmacological property: bitter, it is cold in nature.Effect Gently, rough, blunt.Major function: restrain, connect arteries and veins, only shouting pain, heat-clearing, removing toxic substances.Bone fracture is cured mainly, arteries and veins wound glues epidemic disease, bloody flux, internal organs heat.

Blood of goats, her numb red element of sound-of anaesthetic name, different name La Ha " errorless anaesthetic mirror ", from bovid goat Blood.Pharmacological property: it is sweet in flavor, it is cool in nature.Major function: removing toxic substances, callus, synthetism, hemostasis, dry Xieri Wusu Symptom.Cure mainly syphilis, muscle damage Wound, bone fracture, wound swelling and pain etc..

Prescription analysis: on the basis of the bulk pharmaceutical chemicals of the 8th kind of embodiment, the raw material medicaments in part by weight addition climbing groundsel, Blood of goats, the convergence of a thousand li luminous energy connect arteries and veins, and only shouting pain assists Cortex Eucommiae swelling and pain relieving, and animal drugs blood of goats is added, and animal and plant medicine has The effect of machine combines, and promotes the healing of bone fracture, the further bone-setting pain stopping for enhancing each medicine of prescription, said medicine Xiang Fuxiang At, play altogether synthetism, swelling and pain relieving effect, thus treatment to various fracture caused by wound, each disease such as dislocation, soft tissue injury.

Preparation method analysis: the root of straight ladybell, rheum officinale, keel are first removed into partial invalidity ingredient with ether, are using acetic acid second respectively Ester, 65% ethyl alcohol, 80% ethyl alcohol extract active component, this processing method, more only with the root of straight ladybell, rheum officinale, keel bulk pharmaceutical chemicals into One step increases the accuracy with Cortex Eucommiae compatibility, then water-bindered pill agent processed is mixed with other drugs, and the purpose is in the base for guaranteeing drug effect On plinth, drug cost is further decreased.Also ingredient confirms that this is theoretical to experimental result, under equal conditions, is made using second The therapeutic effect that Preparation Method obtains is higher than the first preparation method, and cure rate, effective percentage, which have, averagely improves 3-5 percentage Point.Preferably second of preparation method, experiment content and data are as follows below.

Cure: union, bone function are wholly or substantially restored.

Invalid: symptom is not any change, and X-ray examination is not any change.

Since 2012, using set a broken bone patient 160 of the present invention, wherein 40 people of Patients with Bone Fracture, fracture of tibia 39 people of patient, 41 people of patellar fracture patient, 40 people of ankle fracture patient, experiment case pass through the attached doctor of National University of the Inner Mongol Institute's diagnosis is made a definite diagnosis, and disease type, number of cases and treatment condition are as follows: experiment case and pass through Affiliated Hospital of Inner Mongolia University for the Nationalities Diagnosis is made a definite diagnosis, and disease type, number of cases and treatment condition are as follows:

As it can be seen that being existed using the cure rate of present invention treatment femoral fracture, fracture of tibia, patellar fracture, ankle fracture 65.8% or more, for total effective rate 87.5% or more, average cure rate is 63.8%, and average total effective rate is 86.9%.Averagely control More rate improves 6.6 percentage points compared with the 8th kind of embodiment, and average total effective rate is unchanged compared with the 8th kind of embodiment, therefore, this Embodiment has apparent progressive compared with the 8th kind of embodiment；Average cure rate improves 1.5 percentages compared with second of embodiment Point, average total effective rate reduce 0.8 percentage point compared with second of embodiment.Therapeutic effect has almost no change, and has received meaning Unimaginable effect.Therefore, above-mentioned raw materials medicine can be used as substitute, to reduce the cost of drug, expand being applicable in for drug Range has wide prospect of the application.

Claims

1. a kind of anaesthetic of bone-setting pain stopping, including Cortex Eucommiae, it is characterised in that: the Cortex Eucommiae and cupreol, rheum emodin, carbonic acid Calcium, glycine, alanine compatibility, above-mentioned anaesthetic are prepared from the following raw materials in parts by weight: 18-22 parts of Cortex Eucommiae, cupreol 0.5-0.8 part, 0.2-0.3 part of rheum emodin, 0.5-1 parts of calcium carbonate, 0.1-0.2 part of glycine, 0.1-0.2 part of alanine.

2. a kind of anaesthetic of bone-setting pain stopping according to claim 1, it is characterised in that: the raw material medicaments in part by weight is added 12-18 parts of safflower, 0.5-1.5 parts of borneol.

3. a kind of anaesthetic of bone-setting pain stopping according to claim 1 or 2, it is characterised in that: the cupreol 0.5- 0.8 part is substituted by 12-18 portions of Radix Notoginseng, and described 0.2-0.3 part of rheum emodin is substituted by 4-6 parts of rheum officinales, the calcium carbonate 0.5- 1 part, 0.1-0.2 part of glycine, 0.1-0.2 part of alanine is substituted by 4-6 parts of pearls processed.

4. a kind of anaesthetic of bone-setting pain stopping according to claim 1 or 2, it is characterised in that: the cupreol 0.5- 0.8 part is substituted by 10-12 parts of wood of shiny-leaved yellowhorn, and described 0.2-0.3 part of rheum emodin is substituted by 4-6 parts of rheum officinales, the calcium carbonate 0.5-1 parts, 0.1-0.2 part of glycine, 0.1-0.2 part of alanine is substituted by 4-6 parts of pearls processed.

5. a kind of anaesthetic of bone-setting pain stopping according to claim 1 or 2, it is characterised in that: the cupreol 0.5- 0.8 part is substituted by 10-12 parts of the root of straight ladybell, and described 0.2-0.3 part of rheum emodin is substituted by 4-6 parts of rheum officinales, the calcium carbonate 0.5- 1 part, 0.1-0.2 part of glycine, 0.1-0.2 part of alanine is substituted by 4-6 parts of pearls processed.

6. a kind of anaesthetic of bone-setting pain stopping according to claim 1 or 2, it is characterised in that: the cupreol 0.5- 0.8 part is substituted by 12-18 portions of Radix Notoginseng, and described 0.2-0.3 part of rheum emodin is substituted by 4-6 parts of rheum officinales, the calcium carbonate 0.5- 1 part, 0.1-0.2 part of glycine, 0.1-0.2 part of alanine is substituted by 2-4 parts of keel.

7. a kind of anaesthetic of bone-setting pain stopping according to claim 1 or 2, it is characterised in that: the cupreol 0.5- 0.8 part is substituted by 10-12 parts of wood of shiny-leaved yellowhorn, and described 0.2-0.3 part of rheum emodin is substituted by 4-6 parts of rheum officinales, the calcium carbonate 0.5-1 parts, 0.1-0.2 part of glycine, 0.1-0.2 part of alanine is substituted by 2-4 parts of keel.

8. a kind of anaesthetic of bone-setting pain stopping according to claim 1 or 2, it is characterised in that: the cupreol 0.5- 0.8 part is substituted by 10-12 parts of the root of straight ladybell, and described 0.2-0.3 part of rheum emodin is substituted by 4-6 rheum officinale, the calcium carbonate 0.5-1 Part, 0.1-0.2 part of glycine, 0.1-0.2 part of alanine is substituted by 2-4 parts of keel.

9. a kind of anaesthetic of bone-setting pain stopping according to claim 8, it is characterised in that: the raw material medicaments in part by weight is added 3-5 parts of climbing groundsel, 4-6 parts of blood of goats.

10. a kind of a kind of preparation method of the anaesthetic of bone-setting pain stopping as described in any one of claim 1-9, feature It is: takes above-mentioned raw materials medicine by weight, crush, sieve with 100 mesh sieve, mixes, add water, the water-bindered pill is made.

11. a kind of a kind of preparation of the anaesthetic of bone-setting pain stopping as described in claim 3 or 4 or 5 or 6 or 7 or 8 or 9 Method, it is characterised in that: take above-mentioned raw materials medicine by the parts by weight, take Radix Notoginseng, rheum officinale, pearl processed or wood of shiny-leaved yellowhorn, rheum officinale, system Pearl or the root of straight ladybell, rheum officinale, pearl processed or Radix Notoginseng, rheum officinale, keel or wood of shiny-leaved yellowhorn, rheum officinale, keel or the root of straight ladybell, rheum officinale, keel, Be put into ether, be ultrasonically treated 40Min, filtering, discard filtrate, take filter residue, be sequentially placed into ethyl acetate, 65% ethyl alcohol, 80% Ethyl alcohol in, under the conditions of 40-50 DEG C, be ultrasonically treated 1h respectively, filter, combined ethyl acetate extracts, 65% ethyl alcohol extracts, Filtrate is concentrated in the filtrate that 80% ethyl alcohol extracts, and makes liquid content 10% -20%, then mix with other bulk pharmaceutical chemicals powder, water is made Ball.