CN102824543A - Yew anti-cancer paste - Google Patents
Yew anti-cancer paste Download PDFInfo
- Publication number
- CN102824543A CN102824543A CN 201210352017 CN201210352017A CN102824543A CN 102824543 A CN102824543 A CN 102824543A CN 201210352017 CN201210352017 CN 201210352017 CN 201210352017 A CN201210352017 A CN 201210352017A CN 102824543 A CN102824543 A CN 102824543A
- Authority
- CN
- China
- Prior art keywords
- cancer
- paste
- effect
- skin
- drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a yew anti-cancer paste, which is an extract of more than ten rare traditional Chinese medicines including taxol, dragon's blood, oldenlandia diffusa and Chinese actinidia root. The external anti-cancer paste is prepared by ultrasonically crushing cytoplasm and coordinating with azone and magnetic chips. The paste has high drug loading capacity, drug factors of quantum particle peptides activate the magnetic memory of the drug factors due to the strong magnetic field function of the magnetic chips, the drug factors rapidly penetrate through the skin and enter the focus and penetrate through the cancer cells in a targeting mode, and the DNA protein chain polymerization is locked and is not depolymerized, so that the cancer cells atrophy, suicide and generate apoptosis. The paste is rapid in effect, high in air permeability, convenient and comfortable, has no toxic or side effect and constant-speed slow release, and has an extremely obvious treatment effect on cancers such as gastrointestinal carcinoma, lung cancer, breast cancer, skin cancer, nasopharynx cancer, laryngeal carcinoma, lymph gland cancer, superficial skin tumor and pancreatic cancer. The anti-cancer paste is simple in process, easy to operate, high in medicine activity and outstanding in antalgic anti-cancer effect.
Description
Technical field
A kind of taxane antineoplastic that the invention belongs in the technical field of medical instruments pastes, and it is by multiple Chinese herbal medicine extract, a kind of exterior-applied formulation behind magnetization, sonic oscillation.
Background technology
At present; It is a lot of to utilize patch to treat the kind of various cancers, though some therapeutic effect are also arranged, its targeting property is poor; More resistant to elevated temperatures chemical compound boils through long-time high temperature; Will certainly cause the disappearance of part physiologically active, each drug molecule is big because of granularity simultaneously, is difficult to transdermal and gets into focus.Therefore, it is low at present comparatively general effect also just to have occurred, and the probability of rehabilitation is not high, is difficult to reach ideal curative effect.
Summary of the invention
Order of the present invention ground is, for many cancers suffer from provide a kind of can direct killing and the external use plaster of trapping cancerous cell, effectively inhibition of pain improves the various uncomfortable disease that causes because of chemicotherapy, can make most of patients reach the effect of healing, its method is:
1, paclitaxel: paclitaxel be the inventor from Ramulus et folium taxi cuspidatae, through the ethanol lixiviate, a kind of semifinished product that ultra-filtration and separation is extracted, content is 5%.The present invention shows through Anticancer Effect and Mechanism research over 4 years, and the medicine that paclitaxel is broken microtubule to the effect of microtubule and vinblastine and this type of autumn waters--limid eyes alkali is opposite.Paclitaxel combines with tubulin, not only can promote polymerization, and strengthens the adhesion of tubulin in this polymer, makes micro-tubular structure keep stable.This paradigmatic structure can discharge the Ca ion by antagonism, destroys the depolymerisation of tubulin medicine.This effect of paclitaxel has been blocked the Hela cell at mitotic cycle G
2With duplicating of M phase, normal cell DNA and RNA or protein synthesis are not had appreciable impact, but that the externally applied anticancer effect is better than is for oral administration.
The physiologically active and the structure activity study of paclitaxel show, taxane and C
13β-carboxylic acid amide esters the base side chain of position is necessary to active anticancer, and the expoxy propane structure also is that active anticancer is necessary.
The pharmacological mechanism of paclitaxel is: microtubule is eukaryotic a kind of ingredient, and it is to be formed by the microtubule dimer that two similar polypeptide (a and β) subunit constitutes.Under normal circumstances, exist dynamic equilibrium between the tubulin dimer.Paclitaxel just can make and lose this dynamic equilibrium between the dimer so, induces and promotes tubulin polymerization, and can prevent depolymerization and lock microtubule.These effects have caused cancerous cell when carrying out mitosis, can not form spindle and chromosomal fibers, have also just suppressed cancerous cell division and very fast propagation, thus the unique antitumor action of performance.
The in vitro study experiment shows; The paclitaxel concentration dependent, be combined on the microtubule to reversibility; Especially be attached on the N end tubulin β subunit; This effect has reduced the required tubulin concentration of polymer, and dynamic equilibrium is moved towards the direction that microtubule assembles, and increases the speed and the storage of microtubule polymerization.The microtubule that taxol induced forms is shorter, and the microtubule flexibility of normal formation is big approximately more than 10 times than without paclitaxel the time.Paclitaxel is to be attached on the microtubule with 1: 1 ratio, shows the normal dynamic regeneration of medicine at the microtubule net, just can prevent the formation of mitosis spindle, causes the chromosomal fracture of cancerous cell, has also just suppressed duplicating and shifting of cancerous cell.Therefore, the effect of adding paclitaxel antagonism kinds of tumors has extremely important treatment meaning.
2, OSW-1 Orsaponin: these article are a kind of crude extracts that the present invention passes through enzymolysis, ethanol lixiviate, ultra-filtration and separation, and content is 5%, include chemical compounds such as abundant Saponin, polysaccharide, flavonoid and alkaloids.The inventor finds in the physiologically active screening experiment; The OSW-1 Orsaponin experiment in vitro shows that its active anticancer is eager to excel 100-1200 doubly than cancer therapy drugs such as the paclitaxel of present clinical use, amycin, camptothecines, and normal cell is not had cytotoxicity.Recent research shows; OSW-1 Orsaponin has very intensive active anticancer; Locking cancerous cell tubulin polymerization that can targeting property and not depolymerization can effectively destroy the mitosis of telomerase, carcinogenic cells atrophy at short notice, suicide, apoptosis.The bioflavonoid material can be regulated the biorhythm of each histoorgan of human body, suppresses the oxidation of oxygen-derived free radicals pair cell, and endocrine regulation promotes microcirculation, can strengthen the function of the heart, brain, liver, lung, kidney, can suppress the effectiveness that mutant changes cancer.Polysaccharide can stimulate and activate the vigor of each immunocyte; Promote the factor of TB lymphocyte, macrophage, cytotoxic cell, NKT sexual cell and BMDC to generate, can promote the antibody-producing capacity of specific immunity, cellular immunization, humoral immunization.Also contain many trace element in the OSW-1 Orsaponin bullion, wherein the content of organic germanium is 2 times of Radix Ginseng, and zinc, selenium are 3 times of the Radix Astragali.What wherein organic germanium and selenium can direct tumoricidal ribonucleic acid is synthetic, has significant effect to suppressing tumor growth.
3, glaucescent fissistigma root alkaloid: this product is to utilize water extraction; A kind of alkaloids crude product that ultra-filtration and separation is obtained; Content is 5%; White leaf fissistigine is wherein arranged; White leaf fissistigine N-oxide, goose are slapped autumn alkali, atherosperminine, atherosperminine N-oxide, oxidation Ke Liebanning, Ku Fuming, are done tree amine, asimilobine, Ke Liebanning, N-methyl atherosperminine cation, hydroxyl xylopine and steroid saponin, flavonoids, polysaccharide, resin, pigment, lipid and mineral matter and other components from giving birth to wood.
Experiment shows; The Radix Fissistigmatis Glaucescentis alkaloid is tested contrast at 99% elaboration and content at 5% semifinished product; Its elaboration antagonism cytotoxicity is not very good; But it is active that 5% crude extract has anti-preferably muscular tumor, and this possibly be the effect that many material compositions are realized through the raising immunity function in the bullion.The toxic and side effects of Radix Fissistigmatis Glaucescentis is less, and the gastrointestinal of stimulation phenomenon is seldom arranged, and does not also damage normal marrow hematopoiesis function; Its specific aim is very strong; It can also protect cell, strengthens normal leukocyte amount, so add 5% the anticancer comparatively ideal of Radix Fissistigmatis Glaucescentis alkaloid cooperation other medicines.
4, Resina garciniae: these article are the dicotyledon medicine, the medicinal Resina garciniae that the colloidal substance process of resin of Guttiferae plant Resina garciniae forms, sour in the mouth, puckery, poisonous.Include guttiferin, gamlogic acid, isomorellin, neomorellin etc.It still is that processed product all has stronger inhibitory action to staphylococcus aureus that Resina garciniae gives birth to article.Gamlogic acid shows the experiment in vitro of various tumors; It is active to have demonstrated good anticancer; And toxic and side effects is less in effective dosage ranges, and the inhibitory action of various tumor cells is had good selectivity and targeting property, can selectively kill and wound cancerous cell; To the not influence of normal cell, hemopoietic system and immunologic function, this is that present tumor chemotherapeutic drug is not available.Pharmacokinetics shows that gamlogic acid is the broad spectrum type antineoplastic agent, and various tumors are had significant curative effect, and is especially best to the tumor efficiency of digestive system.Therefore, the synergism of interpolation Resina garciniae and other medicines is comparatively outstanding.
5, Sanguis Draxonis: Sanguis Draxonis is that the resin refine in the Folium Dracaenae cambodianae rattan leaf forms, and sweet-salty has stink smell, is similar to the Fructus Gardeniae abnormal smells from the patient, maroon or brown-black.Sanguis Draxonis cures mainly the key medicine of dissipating blood stasis blood, tissue regeneration promoting blood, main removing mass blood incised wound, pain relieving granulation promoting, the five internal organs pathogenic heat of dispelling gas, leukorrhagia, damp and hot blood trouble, removing heat from blood, heat extraction, only all pain, the twinge of QI and blood stirring property.Add Sanguis Draxonis internal organs pathogenic heat noxious dampness and various cancer are had effect such as blood circulation promoting and blood stasis dispelling, pain relieving preferably.
6, Herba Hedyotidis Diffusae: these article are the herb of Rubiaceae annual herb plant Herba Hedyotidis Diffusae.Mildly bitter flavor, sweet, cold in nature.Go into stomach, large intestine, small intestinal, stomach warp.Has the disappear effect of pain of heat-clearing and toxic substances removing, dampness removing.Main treatment acute appendicitis and skin ulcer furuncle toxic swelling, laryngopharynx swelling and pain, venom; Be used to treat gastric cancer, esophageal carcinoma, rectal cancer, colon cancer, breast carcinoma etc.; Be used for pyretic stranguria, dysuria, in addition expand coronary vasodilator, cholesterol reducing, bring high blood pressure down, to the effect of coronary heart disease, cardiac muscle stalk, skein cell, leukocytic phagocytic activity are strengthened, reach the order ground of anti-inflammation.
7, Pseudobulbus Cremastrae Seu Pleiones: these article are the bulb of the dryer section of Liliaceae herbaceos perennial Cremastra appendiculata, pleione bulbocodioides or Yunnan pleione bulbocodioides.Acrid in the mouth, cold in nature, slightly poisonous.Go into liver, spleen channel.These article have the effect that heat-clearing and toxic substances removing, eliminating carbuncle loose.Be mainly used in carbuncle, the swollen malignant boil of furuncle.Be used for breast carcinoma, nasopharyngeal carcinoma, pulmonary carcinoma and skin carcinoma etc.These article contain autumn waters--limid eyes alkali, have the antitumor action similar with vinblastine, effectively the mitosis of anticancer nuclear.
8, Fructus Polygoni Orientalis: the medicinal plants of the Northeast, road, Fructus Polygoni Orientalis possession, another name: bright pink son, recover is real, belongs to the seed of annual herb plant.Have diffusing blood eliminating mass, removing food stagnancy analgesic effect is used for that lump in the abdomen mass in the abdomen, goiter swell and ache, food stagnation does not disappear, gastral cavilty distending pain etc., and various tumors are had the obvious suppression effect.
9, Radix Actinidiae Chinensis: these article belong to the root of macaque peach tree, sour in the mouth, puckery, and cool in nature, effect is heat-clearing and toxic substances removing, expelling wind and removing dampness, the effect of diuresis hemostatic.Include abundant flavonoid, actinidine, organic acid, saccharide, pigment, anti-bad thrombosis, mineral matter and other components.Radix Actinidiae Chinensis can be good at improving patient's body quality, can effectively improve self antineoplastic ability, and is particularly outstanding to the effect of treatment kinds of tumors.Radix Actinidiae Chinensis is except having heat-clearing and toxic substances removing and antitumor action; Can also improve patient's multiple symptom, as: icteric sclera, yellowish body, thirsty, in the heart unhappy, asthenia is unable, distension and fullness in the abdomen, symptoms such as lack of appetite is indigestion and loss of appetite, detest is greasy, nausea and vomiting, yellowish or reddish urine, constipation.
10, Herb Gynostemmae Pentaphylli: these article are Cucurbitaceae, Gynostemma, and the herb of herbaceous perennial vine plant is cold in nature, and sweet in the mouth, little hardship are gone into spleen, lung, kidney channel.Include flavonoid, Saponin class, polysaccharide and microelement kind, its effect mainly is the effect that promotes body fat substance metabolism, trophocyte, endocrine regulation and detoxicating, relieving inflammation.Modern medicine study shows that Herb Gynostemmae Pentaphylli also has following many-sided function:
(1) blood fat reducing, blood pressure lowering, blood sugar lowering;
(2) arteriosclerosis, inhibition thrombosis, treatment cardiovascular disease;
(3) calm the nerves and nourish one's nature, slow down aging, improve mental activity, improve cerebral function;
(4) the activating human body normal cell, suppress obesity, strengthening the spleen and stomach, separate fatigue, tranquilizing soporific arranged, antitonic, treatment migraine;
(5) cancer-resisting can be grown by anticancer, strengthens the activity of blood medium-sized lymphocyte, enhancing immunity;
(6) can eliminate the toxic and side effects of hormone medicine;
(7) antiinflammatory, inhibition gastric ulcer and tumor;
(8) constipation is had better effect.
11, azone: these article belong to medical type water solublity white liquid, and are as clear as crystal, are a bit sticky, and purity is 98%, and proportion has dermal osmosis effect preferably for the 0.904-0.914. azone.Be utilized in outer sticking, can significantly improve the curative effect of medicine, reduce dosage and side effect.Show through repeatedly testing; The azone of adding 1% in 5-fluorouracil; The penetrating power of its medicine can improve 80 times, and 5% azone can make stabile utilization rate improve 46 times, and 2% azone can make the externally applied plaster osmosis of wind-damp dispelling quite not add azone increases by 30 times.Therefore, the interpolation azone can improve more than tens times the therapeutic effect of antitumor external application.
12, medical petrolatum oil: these article have that hot melt is good, and condensation is fast, chafe not, and characteristics such as nontoxic add medical petrolatum oil, can play not ixoderm skin, can produce the isolated state form with ointment with skin after miscible, play lubricated effect.
13, Colophonium powder: these article are that pinaster secretes a kind of Colophonium powder that similar resinoid viscoid processes from strand; Nontoxic; The fragrant body odour of dense pinaster is arranged, add Colophonium powder and vaseline oil and medicinal liquid miscible after, can play rapid condensation, mastic surface smoothing, advantage such as adhesive tape skin hair not.
14, ndfeb disk: these article are set at round shape, diameter 10mm, wall thickness 1mm.Ndfeb disk has stronger stationary magnetic field effect; Can pharmaceutical compositions be injected skin through dermal osmosis moment of azone, get into focus fast, under the effect of strong magnetic ray; Can the macromolecular drug granule be smashed; Make human body more be prone to absorb, can promote microcirculation simultaneously, improve endocrine and analgesic effect.
15, spun laced fabric pastes and plastic hoop: the present invention is that the spun laced fabric that adopts the beneficial forever Sanitary Materials Factory in Jiaxiang, Shandong to produce pastes and plastic hoop, this spun laced fabric paste have good permeability, the water-soluble glue stickup time is long, not irritated, noresidue, perspiration difficult drop-off, with advantages such as medicine generation reaction, safety and sanitation.Plastic hoop is to be fixed on the centre that spun laced fabric pastes, and to prevent the mastic not outwards effect of profit stream at normal temperatures, designing requirement is that spun laced fabric pastes 10 * 11cm, plastic hoop circular outer diameter 6.5cm, internal diameter 4.5cm, wall thickness 2mm.
16, the manufacture method of taxane antineoplastic subsides:
(1) get paclitaxel bullion powder 8g, OSW-1 Orsaponin bullion powder 6g, Radix Fissistigmatis Glaucescentis alkaloid bullion powder 6g, goa powder 6g, Sanguis Draxonis powder 4g mixes the back as the A agent, and is for use;
(2) get Herba Hedyotidis Diffusae 15g, Pseudobulbus Cremastrae Seu Pleiones 15g, Herb Gynostemmae Pentaphylli 15g, Fructus Polygoni Orientalis 15g, Radix Actinidiae Chinensis 15g mixes back micronizing 300 orders, adds magnetic water 2000ml, soaks 2 hours.The order ground that soaks with magnetic water is: because the hydrone after magnetizing is less, can the rapid osmotic drug particles in, make its rapid expanding, impel the composition in the drug particles to separate out fast.Decocted 5 minutes with very hot oven then,, filter extracting juice with 500 mesh filter screens changing slow fire decoction 8 minutes into; After in filtering residue, adding 1500ml magnetic water continuation decoction, decocting 3 times successively, waste, filtrating merges; Carry out 85 ℃ of water-bath volatilizations of indirect moisture, when being concentrated into 100ml, inwardly adding magnetic water 50ml, azone 6ml; After stirring, put into the ultrasonic oscillator sonic oscillation 10 minutes of 50HZ, as the B agent, for use;
(3) the B agent solution is put in the A agent; Adding medical petrolatum oil 50g, Colophonium powder 20g, indirect was carried out sonic oscillation 20 minutes for 65 ℃; Its objective is: through sonic oscillation drug molecule is ground into quantum particle peptide level, also just more helps dermal osmosis, absorption and utilization.
(4) spun laced fabric of getting 10 * 11cm pastes, and plastic hoop is placed the centre of pasting, and the central point of ring is being put 1 of a ndfeb disk; Mastic after the vibration is taken out, and to the central point injection 3g of plastic hoop mastic, the beach is flat, condensation; Cover completely with plastic film paper, promptly become taxane antineoplastic and paste.
The present invention is according to Chinese medicine inner disease outer treat principle; Adopt multiple rare Chinese medicine extract to combine with modern quantum medicine technology; Adopt spun laced fabric to paste strong magnetic action for medicine carrying platform and stationary magnetic field; Have that drug loading is big, penetration power is strong, rapid-action, at the uniform velocity slow release, good permeability, easy to use, comfortable etc.
17, clinical experiment:
(1) Liu, 49 years old, the right breast of patient had the swollen greatly thing some months of egg, and hospital's pathologic finding is examined and is breast carcinoma; The patient disagreeing with under the situation of operation, and makes 45 days chemicotherapies, and the big swollen thing of Semen Juglandis appears again in left breast after 4 months, and follows bilateral oxter and cervical region extensively to shift; Under the situation that hospital can't continue to treat, the examination of seeking help is pasted, and each breast affected part is pasted two; Two arches of the foot respectively paste 1, exchange cards containing all personal details and become sworn brothers 1 time in 2 days, paste the pain on the same day control and have much and alleviate; The cancer piece progressively dwindles after 10 days, and pain all disappears, and appetite is seen and increased.Manifold card 30 days, local cancerous protuberance is all eliminated, and mental status is got better.Manifold card 2 months, returning to level before the disease, after change extract oral conditioning 1 month into, do not see recurrence in 16 months so far.
(2) case checking: with these subsides treatment breast carcinoma 49 examples, 34 examples of fully recovering, effective 11 examples, produce effects 2 examples, invalid 2 examples, total effective rate is 95.9%.
(3) 3 routine patient with breast cancers operation is arranged after chemicotherapy is treated rehabilitation, recurrence successively in 4-6 month with the rehabilitation of 2 months priorities of these subsides manifold card, was not seen recurrence in 6 months so far.
(4) paste umbilicus and two arches of the foot (promptly two Yongquan acupoint place) treatment rectal cancer 78 examples with these subsides, wherein I phase effective percentage is 100%, and the II phase is 98.3%, and the III phase is 96.3%, and the IV phase is 81.9%.
(5) paste umbilicus and two arch of the foot punishment treatment colon cancer 19 examples with these subsides, cure 11 examples, effective 8 examples, total effective rate is 100%.
(6) be attached to umbilicus and two arch of the foot punishment treatment colorectal cancer 23 examples with these subsides, cure 20 examples, effective 3 examples, total effective rate is 100%.
(7) paste umbilicus and two arch of the foot places with these subsides, treatment gastric cancer 10 examples are cured 7 examples, effective 3 examples, and effective percentage is 100%.
(8) paste throat appearance affected part with these subsides, treatment laryngeal carcinoma 6 examples, 4 examples of fully recovering, effective 2 examples, effective percentage is 100%.
(9) with the following position of these subsides subsides throat, treat the esophageal carcinoma 9 examples, 6 examples of fully recovering, effective 3 examples, effective percentage is 100%.
(10) with these subsides lagging table affected part, treatment skin carcinoma 3 examples, 3 examples of fully recovering were not seen recurrence in 8 months so far.
The pharmaceutical agent that taxane antineoplastic of the present invention pastes is to release energy through the quantum form, under the effect in azone and magnetic field, and can be in transient absorption and entering focus; Absorb soon, more abundant, targeting property is strong; The disorder of simultaneously can also be handsome just impaired immunocyte electronic frequency; Impel its functionalization, can also improve body metabolism, endocrine and microcirculation, can ease pain and alleviate the toxic and side effects reaction that causes because of chemicotherapy.
The specific embodiment
1, get paclitaxel bullion powder 8g, OSW-1 Orsaponin 6g, Radix Fissistigmatis Glaucescentis alkaloid 6g, Resina garciniae 6g, Sanguis Draxonis 4g mixes the back as the A agent, and is for use;
2, get Herba Hedyotidis Diffusae 15g, Pseudobulbus Cremastrae Seu Pleiones 15g, Herb Gynostemmae Pentaphylli 15g, Fructus Polygoni Orientalis 15g, Radix Actinidiae Chinensis 15g; Mix micronizing 300 orders, add magnetic water 2000ml and soaked 2 hours, decocted 5 minutes,, filter with 500 mesh filter screens changing slow fire decoction 8 minutes into very hot oven; Extracting juice, after in filtering residue, adding 1500ml magnetic water continuation decoction, decocting 3 times successively, waste, filtrating merges; Adding 85 ℃ of water-bath volatilization moisture indirectly, be concentrated into 100ml, inwardly adding 50ml magnetic water, azone 6ml; After stirring, the excusing from death wave oscillator of putting into 50HZ plays sound oscillation 10 minutes, and is as the B agent, for use;
3, the B agent solution is put in the A agent, added medical petrolatum oil 50g, Colophonium powder 20g, indirect was carried out sonic oscillation 20 minutes for 65 ℃.
4, the spun laced fabric of getting 10 * 11cm pastes, and plastic hoop is placed the centre of pasting, and the central point of ring is being put 1 of a ndfeb disk, and the mastic after the vibration is taken out, and injects the 3g mastic to the central point of plastic hoop, and the beach is flat, and condensation covers completely with plastic film paper and to get final product.
Claims (1)
1. the B agent solution is put in the A agent, added medical petrolatum oil 50g again, Colophonium powder 20g, indirect was carried out sonic oscillation 20 minutes for 65 ℃.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210352017 CN102824543A (en) | 2012-09-21 | 2012-09-21 | Yew anti-cancer paste |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210352017 CN102824543A (en) | 2012-09-21 | 2012-09-21 | Yew anti-cancer paste |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102824543A true CN102824543A (en) | 2012-12-19 |
Family
ID=47327989
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201210352017 Pending CN102824543A (en) | 2012-09-21 | 2012-09-21 | Yew anti-cancer paste |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102824543A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103768040A (en) * | 2014-01-21 | 2014-05-07 | 马鞍山汉思生物科技有限公司 | Preparation method of paclitaxel dressing bin and prepared paclitaxel dressing bin |
| CN105797059A (en) * | 2016-03-13 | 2016-07-27 | 周崇立 | Anticancer paste |
-
2012
- 2012-09-21 CN CN 201210352017 patent/CN102824543A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103768040A (en) * | 2014-01-21 | 2014-05-07 | 马鞍山汉思生物科技有限公司 | Preparation method of paclitaxel dressing bin and prepared paclitaxel dressing bin |
| CN103768040B (en) * | 2014-01-21 | 2016-10-05 | 马鞍山汉思生物科技有限公司 | The preparation method in a kind of paclitaxel dressing storehouse and prepared paclitaxel dressing storehouse thereof |
| CN105797059A (en) * | 2016-03-13 | 2016-07-27 | 周崇立 | Anticancer paste |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102784363B (en) | Traditional Chinese medicine composition for treating pancreatic cancer and preparation method thereof | |
| CN108853366A (en) | A kind of drug that can promote and improve sleep quality and its production method | |
| CN103099833A (en) | Soft capsule helpful for relieving sports fatigue and delaying aging and preparation method thereof | |
| CN101361876B (en) | Wound-healing tissue-promoting powder and preparation method thereof | |
| CN1109554C (en) | Medicine for treating allergic purpura | |
| CN104027462B (en) | A kind of Chinese medicine preparation for the treatment of osteoarthritis and preparation method thereof | |
| CN107998365A (en) | A kind of conditioning skin, the Chinese medicine and preparation method thereof of body inferior health | |
| CN103736017A (en) | Traditional Chinese medicine composition for treating intercostal neuralgia and preparation method of traditional Chinese medicine composition | |
| CN102824543A (en) | Yew anti-cancer paste | |
| CN106620402A (en) | Traditional Chinese medicine composition taken after operation of liver cancer and preparation method thereof | |
| CN107126509A (en) | A kind of anticancer pharmaceutical composition and application thereof | |
| CN102626471B (en) | Traditional Chinese medicine composition with effects of anti-anaphylaxis, desensitization, repair and regeneration | |
| CN104666671A (en) | Anti-cancer analgesic medicine of Chinese yew and preparation method of anti-cancer analgesic medicine | |
| CN109771567A (en) | A kind of formula of Chinese herbal medicine supporting vital QI and dispersing blood stasis toxin expelling tumour | |
| CN103007088A (en) | Bamboo tea detoxifying patch | |
| CN103784651A (en) | Medicine composition for treating intestinal obstruction of horses | |
| CN107854685A (en) | A kind of Chinese medicine composition with antitumor action and its production and use | |
| CN104644937A (en) | Spray for treating vasospasm and preparation method of spray | |
| CN102091181A (en) | Chinese medicinal composition for treating acute and chronic granulocytic leukemia 1 and preparation method thereof | |
| CN106581356A (en) | Chinese patent medicine for treating cancer and preparation method thereof | |
| CN104998019A (en) | Traditional Chinese medicine composition for promoting blood circulation for removing blood stasis and reliving bleeding and pain | |
| CN105012642A (en) | Preparation method of traditional Chinese medicine composition capable of promoting blood circulation to remove blood stasis, and stopping bleeding and relieving pain | |
| CN105770081A (en) | Composition preparation used for promoting healing after cerebral hemorrhage operation and preparation method thereof | |
| CN104707003B (en) | The Chinese medicinal capsule for the treatment of hypertension, hyperlipidemia | |
| CN104189667A (en) | Traditional Chinese medicine composition for preventing or treating tumor complication constipation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20121219 |