CN109381917A - The filling preceding sterilization filter device of medical fluid, aseptic filtration method, bulking system and packaging process - Google Patents
The filling preceding sterilization filter device of medical fluid, aseptic filtration method, bulking system and packaging process Download PDFInfo
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- CN109381917A CN109381917A CN201811406778.7A CN201811406778A CN109381917A CN 109381917 A CN109381917 A CN 109381917A CN 201811406778 A CN201811406778 A CN 201811406778A CN 109381917 A CN109381917 A CN 109381917A
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- medical fluid
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- filter
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D36/00—Filter circuits or combinations of filters with other separating devices
- B01D36/001—Filters in combination with devices for the removal of gas, air purge systems
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Abstract
The invention discloses a kind of filling preceding sterilization filter devices of medical fluid, including medical fluid sterilizing filter, medical fluid sterilizing filter is equipped with inlet tube, outlet tube and exhaust pipe, exhaust pipe is located at the top of medical fluid sterilizing filter, it further include the first air filter, exhaust pipe is equipped with first row air valve and is connected with the air inlet of the first air filter, and the gas outlet of the first air filter is equipped with second row air valve.Its aseptic filtration method, comprising steps of exhaust: closing outlet tube, open first row air valve and second row air valve, inlet tube feed liquor, until closing first row air valve and second row air valve after gas is discharged in medical fluid sterilizing filter；Liquid out: inlet tube keeps feed liquor, opens outlet tube, and filtered medical fluid is exported through outlet tube.The present invention further discloses a kind of bulking systems and its packaging process comprising the filling preceding sterilization filter device of above-mentioned medical fluid.The present invention has many advantages, such as that structure is safe and reliable, is conducive to avoid liquid medicine contamination, reduces liquid waste.
Description
Technical field
The present invention relates to medical fluid Canning Technique more particularly to a kind of filling preceding sterilization filter devices of medical fluid, aseptic filtration side
Method, medical fluid bulking system and packaging process.
Background technique
Sterile filling device for pharmaceutical production usually all can configure hydrophilic degerming on the filling pipeline of product
Filter, for filling preceding to medical fluid progress aseptic filtration, when medical fluid is filled into filter, the air of filter top will try
Discharge just can make medical fluid be filled into entire filter interior, to make full use of the filter area of filter core.Existing filter row
Gas is usually manual exhaust, i.e., manually unscrews the exhaust outlet of filter top until spraying a small amount of medical fluid and then turning off exhaust
Mouthful, this structure be easy to cause the waste of medical fluid, while there is also the risks of liquid medicine contamination.
Summary of the invention
The technical problem to be solved by the present invention is to overcome the deficiencies in the prior art, and it is safe and reliable, advantageous to provide a kind of structure
In the filling preceding sterilization filter device of medical fluid for avoiding liquid medicine contamination.
The present invention further provides a kind of aseptic filtration methods of above-mentioned filling preceding sterilization filter device of medical fluid.
The present invention further provides a kind of bulking systems comprising the filling preceding sterilization filter device of above-mentioned medical fluid.
The present invention further provides a kind of packaging process of above-mentioned bulking system.
In order to solve the above technical problems, the invention adopts the following technical scheme:
A kind of filling preceding sterilization filter device of medical fluid, including medical fluid sterilizing filter are set on the medical fluid sterilizing filter
There are inlet tube, outlet tube and exhaust pipe, the exhaust pipe is located at the top of the medical fluid sterilizing filter, removes before medical fluid is filling
Bacterium filter device further includes the first air filter, the exhaust pipe be equipped with first row air valve and with first air filtration
The air inlet of device is connected, and the gas outlet of first air filter is equipped with second row air valve.
As a further improvement of the above technical scheme: the filling preceding sterilization filter device of medical fluid further includes PLC controller, institute
Exhaust pipe is stated equipped with level sensing component, the level sensing component is located at the first row air valve and the medical fluid degerming
Between filter, the signal input part of PLC controller is connected with the level sensing component, the first row air valve and described second
Exhaust valve is connected with the signal output end of PLC controller.
As a further improvement of the above technical scheme: the exhaust pipe is in the level sensing component and the first row
Breeze way is equipped between air valve.
As a further improvement of the above technical scheme: the inlet tube is equipped with the adjusting for adjusting feed speed
Valve.
A kind of aseptic filtration method of the filling preceding sterilization filter device of above-mentioned medical fluid, comprising the following steps:
S1, exhaust: closing outlet tube, opens first row air valve and second row air valve, inlet tube feed liquor, until medical fluid degerming
After gas is discharged in filter, first row air valve and second row air valve are closed；
S2, go out liquid: inlet tube keeps feed liquor, opens outlet tube, and filtered medical fluid is exported through outlet tube.
As a further improvement of the above technical scheme: in step S1, when liquid level rises to level sensing component, liquid level
Detection part issues liquid level signal to PLC controller, and PLC controller issues shutdown signal to first row air valve and the second row
Air valve.
As a further improvement of the above technical scheme: inlet tube feed speed is feed liquor in V1, step S2 in step S1
Pipe feed speed is V2, then V1 < V2.
A kind of medical fluid bulking system, including buffer container further include that the second air filter and above-mentioned medical fluid are filling
Preceding sterilization filter device, the outlet tube are equipped with liquid valve and are connected with the inlet of the buffer container, and the buffering is held
The liquid outlet of device is connected with more than one filling valve, and second air filter is equipped with air inlet pipe and an air outlet pipe, described
Air inlet pipe is equipped with pressure reducing valve and pressure gauge, and the escape pipe is equipped with air outlet valve and the air inlet phase with the buffer container
Even.
A kind of packaging process of above-mentioned medical fluid bulking system, comprising the following steps:
S1, exhaust: the liquid valve on closing outlet tube, opening first row air valve and second row air valve, inlet tube feed liquor, until
After gas is discharged in medical fluid sterilizing filter, first row air valve and second row air valve are closed；
S2, go out liquid: inlet tube keeps feed liquor, opens the liquid valve on outlet tube, and filtered medical fluid is exported through outlet tube
To buffer container；
S3, pressurization: after the medical fluid in buffer container reaches setting value, liquid valve and each filling valve are closed, then open outlet
Valve, until the pressure in buffer container closes air outlet valve after reaching setting value；
It is S4, filling: open each filling valve carry out it is filling.
Compared with the prior art, the advantages of the present invention are as follows: the filling preceding sterilization filter device of medical fluid disclosed by the invention, it will
Exhaust pipe at the top of medical fluid sterilizing filter is connected with an air filter, and first row air valve is arranged on exhaust pipe, at this
Second row air valve is set on the gas outlet of air filter and opens first row air valve when medical fluid sterilizing filter is vented into medical fluid
With second row air valve, the air in medical fluid sterilizing filter is smoothly discharged, simultaneously because it is provided with air filter, energy
It enough avoids external environment pollution medical fluid from showing that air is drained when occurring medical fluid in exhaust pipe, the should be immediately closed off at this time
One exhaust valve and second row air valve, are back to the medical fluid in exhaust pipe in medical fluid sterilizing filter, advantageously reduce medical fluid wave
Take.
The aseptic filtration method of the filling preceding sterilization filter device of medical fluid disclosed by the invention, can be effectively discharged out medical fluid and remove
Air in bacterium filter, makes full use of the filter area of medical fluid sterilizing filter inner filter core, and advantageously reduces liquid waste,
Medical fluid is avoided to be polluted by external environment.
Bulking system disclosed by the invention comprising the above-mentioned filling preceding sterilization filter device of medical fluid, thus is likewise supplied with
State advantage.
Packaging process disclosed by the invention comprising above-mentioned aseptic filtration method, thus equally has the above advantages.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of the filling preceding sterilization filter device of the medical fluid in the present invention, medical fluid bulking system.
Structural schematic diagram when Fig. 2 is the medical fluid sterilizing filter feed liquor exhaust in the present invention.
Structural schematic diagram when Fig. 3 is the medical fluid bulking system feed liquor in the present invention.
Structural schematic diagram when Fig. 4 is the medical fluid bulking system pressurization in the present invention.
Fig. 5 is the structural schematic diagram when medical fluid bulking system in the present invention is filling.
Each label indicates in figure: 1, medical fluid sterilizing filter；11, inlet tube；12, outlet tube；13, exhaust pipe；131, delay
Rush section；14, first row air valve；15, level sensing component；16, liquid valve；17, regulating valve；2, the first air filter；21,
Two exhaust valves；3, buffer container；31, filling valve；4, the second air filter；41, air inlet pipe；42, pressure reducing valve；43, pressure gauge；
44, escape pipe；45, air outlet valve.
Specific embodiment
Below in conjunction with Figure of description and specific embodiment, invention is further described in detail.
Embodiment one
Fig. 1 shows a kind of embodiment of the filling preceding sterilization filter device of medical fluid of the present invention, and the medical fluid of the present embodiment is filling
Preceding sterilization filter device, including medical fluid sterilizing filter 1, medical fluid sterilizing filter 1 be equipped with inlet tube 11, outlet tube 12 and
Exhaust pipe 13, exhaust pipe 13 are located at the top of medical fluid sterilizing filter 1, and the filling preceding sterilization filter device of medical fluid further includes the first sky
Air filter 2, exhaust pipe 13 are equipped with first row air valve 14 and are connected with the air inlet of the first air filter 2, the first air
The gas outlet of filter 2 is equipped with second row air valve 21.Wherein, arrow indicates the flow direction of medical fluid or gas；Medical fluid sterilizing filter 1
Such as can be common hydrophilic filters, first row air valve 14, the preferred pneumatic diaphragm valve of second row air valve 21 are convenient for
Automation control.The medical fluid filling preceding sterilization filter device opens first exhaust when medical fluid sterilizing filter 1 is vented into medical fluid
Valve 14 and second row air valve 21, are smoothly discharged the air in medical fluid sterilizing filter 1, simultaneously because being provided with the first sky
Air filter 2 can be avoided the air in external environment and enter pollution medical fluid in medical fluid sterilizing filter 1, when in exhaust pipe 13
When there is medical fluid, show that air is drained in medical fluid sterilizing filter 1, should immediately close off first row air valve 14 and second at this time
Exhaust valve 21 is back to the medical fluid in exhaust pipe 13 in medical fluid sterilizing filter 1, advantageously reduces liquid waste.
Further, in this embodiment the filling preceding sterilization filter device of the medical fluid of the present embodiment further includes PLC controller
(being not shown in the figure, commercially available), exhaust pipe 13 are equipped with level sensing component 15, and level sensing component 15 is located at first row air valve
Between 14 and medical fluid sterilizing filter 1, the signal input part of PLC controller is connected with level sensing component 15, first row air valve
14 and second row air valve 21 be connected with the signal output end of PLC controller.Wherein, level sensing component 15 preferably uses liquid level
Detecting electrode.When level sensing component 15 detects liquid medicine spill, signal is issued to PLC controller, PLC controller output is closed
Close signal, immediately close off first row air valve 14 and second row air valve 21, avoid medical fluid continue overflow be more than first row air valve 14 (when
When medical fluid continues to overflow more than first row air valve 14 is turned off after first row air valve 14, the medical fluid of spilling can not be back to medical fluid and remove
It in bacterium filter 1, causes to waste, while medical fluid may will affect 2 filter core of the first air filter into the first air filter 2
Performance), avoid artificial participation, improve the degree of automation.
Further, in the present embodiment, exhaust pipe 13 is equipped between level sensing component 15 and first row air valve 14
Breeze way 131, namely appropriate increase the distance between level sensing component 15 and first row air valve 14, are used as buffering.Due to from
Level sensing component 15 finds that liquid medicine spill to first row air valve 14 and second row air valve 21 is closed, when needing certain movement
Between, breeze way 131 is set, is conducive to avoid liquid medicine spill to be more than that first row air valve 14 causes liquid waste, influences the first air
The performance of 2 filter core of filter.
Further, in this embodiment inlet tube 11 is equipped with the regulating valve 17 for adjusting feed speed, it is preferred to use
Pneumatic control valve realizes the adjusting into medical fluid speed by adjusting aperture.Exhaust when, can use lesser aperture, with compared with
Slow speed feed liquor facilitates the discharge of control gas；After completing exhaust, protected using biggish aperture with faster speed feed liquor
Demonstrate,prove subsequent filling efficiency.
Embodiment two
Fig. 2 to Fig. 3 shows a kind of embodiment of the aseptic filtration method of the filling preceding sterilization filter device of medical fluid of the present invention,
The aseptic filtration method of the filling preceding sterilization filter device of the medical fluid of the present embodiment comprising following steps:
S1, exhaust: closing outlet tube 12, opens first row air valve 14 and second row air valve 21,11 feed liquor of inlet tube, until medicine
After gas is discharged in liquid sterilizing filter 1, first row air valve 14 and second row air valve 21 are closed；
S2, go out liquid: inlet tube 11 keeps feed liquor, opens outlet tube 12, and filtered medical fluid is exported through outlet tube 12.
The aseptic filtration method of the filling preceding sterilization filter device of the medical fluid, can be effectively discharged out medical fluid sterilizing filter 1
Interior air, makes full use of the filter area of 1 inner filter core of medical fluid sterilizing filter, and advantageously reduces liquid waste, avoids medicine
Liquid is polluted by external environment.
Further, in this embodiment in step S1, when liquid level rises to level sensing component 15, level sensing portion
Part 15 issues liquid level signal to PLC controller, and PLC controller issues shutdown signal to first row air valve 14 and second row air valve
21, can continue to overflow in this way to avoid medical fluid is more than first row air valve 14 (after medical fluid, which continues to overflow, is more than first row air valve 14
When turning off first row air valve 14, the medical fluid of spilling can not be back in medical fluid sterilizing filter 1, cause to waste, while medical fluid
The performance of 2 filter core of the first air filter may be will affect into the first air filter 2), artificial participation is avoided, is improved
The degree of automation and precision.
Further, in the present embodiment, in step S1 11 feed speed of inlet tube be V1, step S2 in inlet tube 11 into
Liquid speed degree is V2, then V1 < V2, filling efficiency when being conducive to control the discharge of gas when exhaust, while guaranteeing subsequent filling.
Embodiment three
Fig. 1 to Fig. 5 shows a kind of embodiment of medical fluid bulking system of the present invention, the medical fluid bulking system of the present embodiment,
It further include the second air filter 4 and the filling preceding sterilization filter device of above-mentioned medical fluid, outlet tube 12 including buffer container 3
It is equipped with liquid valve 16 and is connected with the inlet of buffer container 3, the liquid outlet of buffer container 3 is connected with more than one filling
Valve 31, the second air filter 4 are equipped with air inlet pipe 41 and escape pipe 44, and air inlet pipe 41 is equipped with pressure reducing valve 42 and pressure gauge
43, escape pipe 44 is equipped with air outlet valve 45 and is connected with the air inlet of buffer container 3.Medical fluid is delivered to buffering by outlet tube 12
In container 3, when the liquid volume in buffer container 3 reaches target value, liquid valve 16 is closed.Compressed air is after pressure reducing valve 42
It is filled into buffer container 3, the medical fluid in buffer container 3 is pressurizeed, close air outlet valve after pressure gauge 43 shows that pressure is constant
45, each filling valve 31 (V06~V11) opens the regular hour, and quantitative liquid medicine is filled in container.Wherein, liquid valve 16,
Pneumatic diaphragm valve can be used in air outlet valve 45 etc., convenient for automatically controlling.
Example IV
Fig. 1 to Fig. 5 shows a kind of embodiment of the packaging process of medical fluid bulking system of the present invention, and the present embodiment medical fluid fills
The packaging process of dress system, comprising the following steps:
S1, exhaust: closing the liquid valve 16 on outlet tube 12, opens first row air valve 14 and second row air valve 21, feed liquor
11 feed liquor of pipe, until closing first row air valve 14 and second row air valve 21 after gas is discharged in medical fluid sterilizing filter 1；
S2, go out liquid: inlet tube 11 keeps feed liquor, opens the liquid valve 16 on outlet tube 12, filtered medical fluid is through going out liquid
In the output to buffer container 3 of pipe 12；
S3, pressurization: after the medical fluid in buffer container 3 reaches setting value, liquid valve 16 and each filling valve 31 are closed, then open
Air outlet valve 45, until the pressure in buffer container 3 closes air outlet valve 45 after reaching setting value；
It is S4, filling: open each filling valve 31 carry out it is filling.
The packaging process of the medical fluid bulking system includes above-mentioned aseptic filtration method, thus equally having can be effectively
The air in medical fluid sterilizing filter 1 is discharged, makes full use of the filter area of 1 inner filter core of medical fluid sterilizing filter, and be conducive to
The advantages of reducing liquid waste, medical fluid avoided to be polluted by external environment.
Although the present invention has been disclosed as a preferred embodiment, however, it is not intended to limit the invention.It is any to be familiar with ability
The technical staff in domain, without deviating from the scope of the technical scheme of the present invention, all using the technology contents pair of the disclosure above
Technical solution of the present invention makes many possible changes and modifications or equivalent example modified to equivalent change.Therefore, all
Without departing from the content of technical solution of the present invention, according to the present invention technical spirit any simple modification made to the above embodiment,
Equivalent variations and modification, all shall fall within the protection scope of the technical scheme of the invention.
Claims (9)
1. a kind of filling preceding sterilization filter device of medical fluid, including medical fluid sterilizing filter (1), the medical fluid sterilizing filter (1)
It is equipped with inlet tube (11), outlet tube (12) and exhaust pipe (13), the exhaust pipe (13) and is located at the medical fluid aseptic filtration
The top of device (1), it is characterised in that: the filling preceding sterilization filter device of medical fluid further includes the first air filter (2), the exhaust
Pipe (13) is equipped with first row air valve (14) and is connected with the air inlet of first air filter (2), first air
The gas outlet of filter (2) is equipped with second row air valve (21).
2. the filling preceding sterilization filter device of medical fluid according to claim 1, it is characterised in that: it further include PLC controller, institute
Exhaust pipe (13) are stated equipped with level sensing component (15), the level sensing component (15) is located at the first row air valve (14)
Between the medical fluid sterilizing filter (1), the signal input part of PLC controller is connected with the level sensing component (15),
The first row air valve (14) and the second row air valve (21) are connected with the signal output end of PLC controller.
3. the filling preceding sterilization filter device of medical fluid according to claim 2, it is characterised in that: the exhaust pipe (13) is in institute
It states and is equipped with breeze way (131) between level sensing component (15) and the first row air valve (14).
4. the filling preceding sterilization filter device of medical fluid according to any one of claim 1 to 3, it is characterised in that: it is described into
Liquid pipe (11) is equipped with the regulating valve (17) for adjusting feed speed.
5. a kind of aseptic filtration method of the filling preceding sterilization filter device of medical fluid described in any one of Claims 1-4, special
Sign is: the following steps are included:
S1, exhaust: closing outlet tube (12), opening first row air valve (14) and second row air valve (21), inlet tube (11) feed liquor,
After being discharged to medical fluid sterilizing filter (1) interior gas, first row air valve (14) and second row air valve (21) are closed；
S2, go out liquid: inlet tube (11) keeps feed liquor, opens outlet tube (12), and filtered medical fluid is exported through outlet tube (12).
6. aseptic filtration method according to claim 5, it is characterised in that: in step S1, when liquid level rises to liquid level inspection
When surveying component (15), level sensing component (15) issues liquid level signal to PLC controller, and PLC controller issues shutdown signal extremely
First row air valve (14) and the second row air valve (21).
7. aseptic filtration method according to claim 5, it is characterised in that: inlet tube (11) feed speed is in step S1
Inlet tube (11) feed speed is V2 in V1, step S2, then V1 < V2.
8. a kind of medical fluid bulking system, including buffer container (3), it is characterised in that: further include the second air filter (4) and
The filling preceding sterilization filter device of medical fluid described in any one of Claims 1-4, the outlet tube (12) are equipped with liquid valve
(16) and with the inlet of the buffer container (3) it is connected, the liquid outlet of the buffer container (3) is connected with more than one filling
It fills valve (31), second air filter (4) is equipped with air inlet pipe (41) and escape pipe (44), sets on the air inlet pipe (41)
Have a pressure reducing valve (42) and pressure gauge (43), the escape pipe (44) be equipped with air outlet valve (45) and with the buffer container (3)
Air inlet is connected.
9. a kind of packaging process of medical fluid bulking system according to any one of claims 8, it is characterised in that: the following steps are included:
S1, exhaust: closing the liquid valve (16) on outlet tube (12), opens first row air valve (14) and second row air valve (21),
Inlet tube (11) feed liquor, until closing first row air valve (14) and second exhaust after medical fluid sterilizing filter (1) interior gas is discharged
Valve (21)；
S2, go out liquid: inlet tube (11) keeps feed liquor, opens the liquid valve (16) on outlet tube (12), filtered medical fluid is through going out
In liquid pipe (12) output to buffer container (3)；
S3, pressurization: after the medical fluid in buffer container (3) reaches setting value, liquid valve (16) and each filling valve (31) are closed, then beat
Air valve (45) are outputed, until the pressure in buffer container (3) closes air outlet valve (45) after reaching setting value；
It is S4, filling: open each filling valve (31) carry out it is filling.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811406778.7A CN109381917A (en) | 2018-11-23 | 2018-11-23 | The filling preceding sterilization filter device of medical fluid, aseptic filtration method, bulking system and packaging process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811406778.7A CN109381917A (en) | 2018-11-23 | 2018-11-23 | The filling preceding sterilization filter device of medical fluid, aseptic filtration method, bulking system and packaging process |
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| Publication Number | Publication Date |
|---|---|
| CN109381917A true CN109381917A (en) | 2019-02-26 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811406778.7A Pending CN109381917A (en) | 2018-11-23 | 2018-11-23 | The filling preceding sterilization filter device of medical fluid, aseptic filtration method, bulking system and packaging process |
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| Country | Link |
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| CN (1) | CN109381917A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113103150A (en) * | 2021-04-23 | 2021-07-13 | 长鑫存储技术有限公司 | Polishing liquid supply system, polishing apparatus, exhaust method, and polishing method |
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