CN208710558U - A kind of on-line system of liquid sterilizing filter steam sterilizing and integrity detection - Google Patents
A kind of on-line system of liquid sterilizing filter steam sterilizing and integrity detection Download PDFInfo
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- CN208710558U CN208710558U CN201721241071.6U CN201721241071U CN208710558U CN 208710558 U CN208710558 U CN 208710558U CN 201721241071 U CN201721241071 U CN 201721241071U CN 208710558 U CN208710558 U CN 208710558U
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- filter
- liquid
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- sterilizing
- integrity detection
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Abstract
The utility model discloses the on-line systems of a kind of liquid sterilizing filter steam sterilizing and integrity detection, including the first air filter, the second air filter, expansion drum, graduated cylinder, pure steam storage tank and compressed air reservoir.On-line system provided by the utility model for liquid sterilizing filter steam sterilizing and integrity detection is easy to operate, whole process can automation control, not by the interference of human factor；It is carried during entire sterilizing and integrity detection without personnel, saves labour, in turn avoid the risk that existing filter integrity is destroyed in the handling process.The on-line system can carry out integrity detection to liquid filter at any time, and can carry out integrity detection after sterilization, in filter process or to filter after filtering, not only will not influence the aseptic of filter, but also can ensure that the safety of filter.
Description
Technical field
The utility model relates to the processing technology fields of liquid sterilizing filter, are used for liquid degerming more particularly to one kind
The on-line system for being completed at the same time steam sterilizing and integrity detection of filter.
Background technique
Liquid sterilizing filter is made of filter core and filter housing, and filter core is mounted in specified filter housing by operating instruction, and quantity is not
It is fixed, depending on specific production technology, filter housing sleeve is finally put on, is fixed with clip or bolt.Filter core generallys use greatly
Specific surface area, the microstraining core that filtering accuracy is 0.22 μm or more, can prevent the impurity and harmful bacteria, micro- life in culture solution
Object etc. enters culture vessel, production line etc., to prevent product contaminated.
Liquid sterilizing filter needs to detect its integrality before use, sterilizes again after detection is qualified.It passes
The process of the liquid sterilizing filter detection integrality of system is as shown in Figure 1, comprising the following steps:
1, it is sufficiently humidified so as to filter core
It is passed through purified water into mounted liquid sterilizing filter I, and ensures that purified water fills entire filter, it is quiet
It sets, filter core is made to be completely sunk in the water 40-50min, it is ensured that filter core is completely wet.
2, integrity test
1) after filter core is completely wet, the sewage draining exit 3 ' of I lower part of filter is opened, the water in filter is all bled off；
2) pressure gauge 5 ', 1 ' place of filter inlet and clean pneumatics piping connection are installed on the top of filter, arrange mouth 2 '
One silica gel hose of place's installation；
3) pressure that clean pneumatics pipeline is adjusted according to the pressure requirements of filter core diffusion current test, observes pressure on filter
The pressure of table closes the import of filter when reaching specified value；Prepare a container for filling water and a graduated cylinder 4 ', by graduated cylinder
Interior topped up with water tips upside down in the container for filling with water, it is ensured that is still filled with water in the graduated cylinder of back-off without air, silica gel hose is put into
In container, the bubble emerged is observed, protrudes into the end of silica gel hose in graduated cylinder when bubble is uniformly emerged, starts simultaneously at meter
When, the bubbles volume that observation is collected in 1 minute compares the standard of filter core diffusion flow, determines whether the integrality of filter is qualified.
After integrity detection, progress height in steam sterilization cabinet is transported to after will test the filter wrapping of result qualification
Press steam sterilizing.
However the integrality of filter can be destroyed because of a variety of factors during carrying filter, seriously affect filter
Filter effect in actual use.But if carrying out an integrity detection after subject to sterilization again not only increases technique
Cost can also introduce impurity into filter, keep filter contaminated, the ineffective sterilization before causing.It therefore, can not after sterilizing
Integrity detection is carried out again, and the filter integrity 100% after not can guarantee sterilizing is qualified.
Utility model content
The purpose of this utility model is provided a kind of for liquid degerming for technological deficiency existing in the prior art
It may be implemented the on-line system of integrity detection and sterilizing while filter, including the first air filter, the second air filter, swollen
Swell, tip upside down in water container and water-filled graduated cylinder, for the on-line system provide sterilizing steam pure steam storage tank and
The compressed air reservoir of integrity detection gas is provided for the on-line system；Wherein, pure steam storage tank and compressed air reservoir
It is connect side by side with the input end of the first air filter, the outlet end of the first air filter and to be detected and sterilizing liquid filter
Arrival end be connected, the outlet end of liquid filter is connected with expansion drum；Expansion drum is equipped with the arrival end with the second air filter
Connected gas vent is additionally provided with the liquid outlet being connected with plumbing drain；The outlet end of second air filter respectively with sewage
Pipeline is connected with graduated cylinder.
It is equipped with first pressure sensor before the arrival end of the liquid filter, second pressure biography is equipped with after outlet end
Sensor.
It further include the storage tank of purified water being arranged in parallel with first air filter.
Further include and first air filter and storage tank of purified water and the feed liquid storage tank to be filtered that is arranged in parallel.
The outlet end of the liquid filter is additionally provided with a filtered fluid tank body in parallel with the expansion drum.
The top of the liquid filter is additionally provided with an exhaust smallmouth.
Pipeline between first air filter and liquid sterilizing filter is equipped with temperature sensor.
Pipeline between the liquid sterilizing filter and expansion drum is equipped with temperature sensor.
Pipeline between second air filter and plumbing drain is equipped with temperature sensor.
Pipeline between the liquid outlet and plumbing drain of the expansion drum is equipped with temperature sensor.
On-line system provided by the utility model for liquid sterilizing filter steam sterilizing and integrity detection is by liquid
Body sterilizing filter first carries out integrity detection online, then in situ carries out steam sterilizing again, can also be after sterilizing
Filter carries out integrity detection under the premise of not moving.Sterilizing and integrity detection are completed in same position, do not have to mobile liquid
Body sterilizing filter, and still can ensure that the integrality of liquid sterilizing filter after sterilization, while after integrity detection still
It can ensure that the aseptic of liquid sterilizing filter.So both can to avoid generated during carrying filter it is uncertain because
Element causes the integrality of filter to be destroyed, and is also able to achieve and detects at any time to the integrality of filter, save technique at
This, reduces influence of the human factor to filter integrity, it is ensured that filter effect of the filter in use process from now on.
Detailed description of the invention
Fig. 1 show the flow chart of liquid sterilizing filter integrity detection in the prior art；
Fig. 2 show the structure of the on-line system of the utility model liquid sterilizing filter steam sterilizing and integrity detection
Schematic diagram.
Specific embodiment
Below in conjunction with specific embodiment, the content of the utility model is further illustrated, and the utility model is made into one
Step illustrates, but these embodiments absolutely not limit the utility model.
On-line system provided by the utility model for liquid sterilizing filter steam sterilizing and integrity detection is such as schemed
Shown in 2, including the first air filter 1, the second air filter 2, expansion drum 3, graduated cylinder 4, first pressure sensor 5, second pressure
Sensor 6, pure steam storage tank 7, compressed air reservoir 8, storage tank of purified water 9, feed liquid storage tank 10 to be filtered, exhaust smallmouth 11, temperature
Spend sensor 12, plumbing drain 13 and several valves.
Wherein,
Pure steam storage tank 7 provides 121 DEG C of vapor for entire on-line system, carries out for the filter core to liquid filter
Sterilizing.Compressed air reservoir 8 provides air for whole system, makes to keep positive pressure in whole system.Pure steam storage tank 7 and compression are empty
Gas storage tank 8 is connect with the input end of the first air filter 1 side by side.First air filter 1 is used to filter vapor and air, it is ensured that
Vapor and air it is sterile, while also providing sterile gas source for the integrity detection of liquid sterilizing filter.First air filter
The outlet end of device 1 is connected with the arrival end of to be detected and sterilizing liquid filter I.The outlet end of liquid filter I connects respectively
It is connected to expansion drum 3, filtered fluid tank body or next stage on-line system 14.The effect of expansion drum 3 is to do integrality in liquid filter
Gas is collected when detection, whether be then used to detect diffusion flow for the gas being collected into qualified.Liquid outlet in expansion drum 3 with
Plumbing drain 13 is connected；Gas vent in expansion drum 3 is connected with the input end of the second air filter 2, is used to air filtering, prevents
Only liquid sterilizing filter air extraneous during integrity detection enters, and pollutes entire on-line system.Second air filter
The outlet end of device 2 is connected with plumbing drain 13, graduated cylinder 4 respectively.Topped up with water is upside down in the water storage container (cross of water storage container in graduated cylinder
Section is greater than graduated cylinder, generally uses bucket) in, the gas by liquid filter is received, the volume of water discharge is in graduated cylinder
The gas flow being collected into determines whether the integrality of liquid filter is qualified with this.Storage tank of purified water 9, feed liquid storage tank to be filtered
10 connect with the arrival end of liquid filter I side by side, and in parallel with the first air filter 1.
The pressure of pure steam is excessive in sterilization process in order to prevent, and the filter membrane of liquid filter is blown brokenly, filter into
When row sterilizing, the pressure difference before and after strict control filter, first pressure is then equipped with before the arrival end of liquid filter
Sensor 5 is equipped with second pressure sensor 6 after outlet end, is sensed by control first pressure sensor 5 and second pressure
Pressure difference between device 6, it can be ensured that filter core is not destroyed.
The process of online steam sterilizing and integrity detection is carried out such as to liquid sterilizing filter using the above on-line system
In Fig. 2 shown in arrow, after heavy black line arrow indicates that the trend of gas, black triangles arrow indicate that vapor is condensed into liquid
Trend, grey triangles arrow indicates the trend of other liquid, specifically:
(1), it is sufficiently humidified so as to filter core
Liquid sterilizing filter is mounted in above-mentioned on-line system, opens the valve of storage tank of purified water 9 to liquid degerming
It is passed through purified water in filter, so that purified water is stood after filling entire filter, filter core is made to be completely sunk in the water 40-50min,
Ensure that filter core is completely wet, as shown in grey triangles arrow in Fig. 2.
(2), integrity detection
As shown in heavy black line arrow in Fig. 2, after the pressure requirements setting pressure of filter core diffusion current test, open
The valve of compressed air reservoir 8 closes valve when pressure reaches prescribed requirement；Topped up with water in graduated cylinder at this time, tips upside down on and fills with
In the container of water, it is ensured that be still filled with water in the graduated cylinder of back-off；The air that compressed air reservoir 8 is discharged passes sequentially through the first air
Filter 1, liquid sterilizing filter I and expansion drum 3.When air reaches expansion drum 3, pressure increase in expansion drum, gas passes through
Second air filter 2 drains into graduated cylinder 4, and the gas flow collected in graduated cylinder in observation 1 minute compares the diffusion flow in filter core specification
Acceptance value determines whether the integrality of filter is qualified, if the gas flow collected in graduated cylinder is higher than the expansion that filter core specification provides
Diffusing acceptance value illustrates that integrality is unqualified, otherwise illustrates integrality qualification.
(3), online steam sterilizing
Testing result is that qualified liquid filter sterilizes continuation automatically, set first pressure sensor 5 and
The pressure difference of second pressure sensor 6 opens the valve of pure steam storage tank 7, the temperature to the temperature sensor 12 on each pipeline
Sterilizing starts when reaching predetermined temperature, and the pure steam that pure steam storage tank 7 is discharged passes sequentially through the first air filter 1, liquid removes
Bacterium filter I and expansion drum 3.When pure steam reaches expansion drum 3, pressure increase in expansion drum, gas passes through the second air filter
Device 2 drains into plumbing drain 13.Pure steam can be condensed into the water of liquid in expansion tube 3, and water is drained by the liquid outlet of expansion drum 3
Plumbing drain 13.
(4), online sterile integrity detection
After sterilizing, when the temperature of liquid filter drops to room temperature, the operation of step (2) is repeated, liquid is filtered
Device carries out integrity detection again, it is ensured that liquid filter is not destroyed in sterilization process, detects qualified product from online
It is removed in system, carries out subsequent technology of the package.
It is provided by the utility model to be operated for liquid sterilizing filter steam sterilizing and the on-line system of integrity detection
Simply, whole process can automation control, not by the interference of human factor；Personnel are not necessarily to during entire sterilizing and integrity detection
It carries, saves labour, in turn avoid the risk that existing filter integrity is destroyed in the handling process.The on-line system
Can at any time to liquid filter carry out integrity detection, and can after sterilization, in filter process or filtering after to filtering
Device carries out integrity detection, not only will not influence the aseptic of filter, but also can ensure that the safety of filter.For example, material to be filtered
Liquid storage tank 10 is connected with liquid filter, and filtered feed liquid can be immediately discharged to filtered fluid tank body, recycling after filtering
The on-line system of the utility model carries out integrity detection to liquid filter.
The above is only the preferred embodiment of the utility model, it is noted that for the general of the art
For logical technical staff, without departing from the principle of this utility model, several improvements and modifications can also be made, these change
Into the content that also should be regarded as the utility model with retouching.
Claims (10)
1. a kind of on-line system of liquid sterilizing filter steam sterilizing and integrity detection, which is characterized in that including the first sky
Air filter device, expansion drum, is tipped upside down in water container and water-filled graduated cylinder, is provided for the on-line system the second air filter
Sterilize steam pure steam storage tank and provide the compressed air reservoir of integrity detection gas for the on-line system；Wherein, pure
Steam storage tank is connect with the input end of the first air filter side by side with compressed air reservoir, the outlet end of the first air filter with to
It detects and is connected with the arrival end of the liquid filter of sterilizing, the outlet end of liquid filter is connected with expansion drum；Expansion drum is equipped with
The gas vent being connected with the arrival end of the second air filter is additionally provided with the liquid outlet being connected with plumbing drain；Second air
The outlet end of filter is connected with plumbing drain and graduated cylinder respectively.
2. on-line system according to claim 1, which is characterized in that be equipped with first before the arrival end of the liquid filter
Pressure sensor, outlet end are equipped with second pressure sensor later.
3. on-line system according to claim 2, which is characterized in that further include being arranged in parallel with first air filter
Storage tank of purified water.
4. on-line system according to claim 3, which is characterized in that further include being stored up with first air filter and purified water
The feed liquid storage tank to be filtered that tank is arranged in parallel.
5. on-line system according to claim 4, which is characterized in that the outlet end of the liquid filter is additionally provided with one and institute
State the filtered fluid tank body of expansion drum parallel connection.
6. -5 any on-line system according to claim 1, which is characterized in that the top of the liquid filter is additionally provided with one
It is vented smallmouth.
7. on-line system according to claim 6, which is characterized in that first air filter and liquid sterilizing filter it
Between pipeline be equipped with temperature sensor.
8. on-line system according to claim 7, which is characterized in that the pipe between the liquid sterilizing filter and expansion drum
Road is equipped with temperature sensor.
9. on-line system according to claim 8, which is characterized in that the pipe between second air filter and plumbing drain
Road is equipped with temperature sensor.
10. on-line system according to claim 9, which is characterized in that the liquid outlet of the expansion drum and plumbing drain it
Between pipeline be equipped with temperature sensor.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721241071.6U CN208710558U (en) | 2017-09-26 | 2017-09-26 | A kind of on-line system of liquid sterilizing filter steam sterilizing and integrity detection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721241071.6U CN208710558U (en) | 2017-09-26 | 2017-09-26 | A kind of on-line system of liquid sterilizing filter steam sterilizing and integrity detection |
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| Publication Number | Publication Date |
|---|---|
| CN208710558U true CN208710558U (en) | 2019-04-09 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201721241071.6U Active CN208710558U (en) | 2017-09-26 | 2017-09-26 | A kind of on-line system of liquid sterilizing filter steam sterilizing and integrity detection |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114307662A (en) * | 2021-12-30 | 2022-04-12 | 江苏汉邦科技有限公司 | Filter element filter membrane integrity testing device |
| CN115824616A (en) * | 2023-02-13 | 2023-03-21 | 潍坊格菲特生物科技有限公司 | On-line integrity test method for filter element of fine filter |
-
2017
- 2017-09-26 CN CN201721241071.6U patent/CN208710558U/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114307662A (en) * | 2021-12-30 | 2022-04-12 | 江苏汉邦科技有限公司 | Filter element filter membrane integrity testing device |
| CN115824616A (en) * | 2023-02-13 | 2023-03-21 | 潍坊格菲特生物科技有限公司 | On-line integrity test method for filter element of fine filter |
| CN115824616B (en) * | 2023-02-13 | 2023-04-14 | 潍坊格菲特生物科技有限公司 | On-line integrity test method for filter element of fine filter |
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