CN109381694A - A kind of composition and preparation method thereof for preventing and treating grice diarrhoea - Google Patents
A kind of composition and preparation method thereof for preventing and treating grice diarrhoea Download PDFInfo
- Publication number
- CN109381694A CN109381694A CN201811024011.8A CN201811024011A CN109381694A CN 109381694 A CN109381694 A CN 109381694A CN 201811024011 A CN201811024011 A CN 201811024011A CN 109381694 A CN109381694 A CN 109381694A
- Authority
- CN
- China
- Prior art keywords
- parts
- composition
- preparation
- water
- grice diarrhoea
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/748—Oldenlandia or Hedyotis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/90—Smilacaceae (Catbrier family), e.g. greenbrier or sarsaparilla
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a kind of compositions and preparation method thereof for preventing and treating grice diarrhoea.Composition of the invention is using climbing groundsel, chinaroot greenbrier, umbellate pore furgus, purslane, oldenlandia diffusa, antibacterial peptide and glucose as raw material, by compounding again after extraction, purifying, spray drying.Chinese medicine and antibacterial peptide components complement each other in composition of the invention, can improve function of intestinal canal in prevention of diarrhea in piglets disease, reduce diarrhea rate, improve efficiency of feed utilization and improve piglet weight gain, can be very good to solve the problems, such as grice diarrhoea.
Description
(1) technical field
The present invention relates to veterinary drug technical fields, and in particular to a kind of composition and its preparation side for preventing and treating grice diarrhoea
Method.
(2) background technique
For piglet because not yet establishing stable microecosystem in enteron aisle, itself resistance is lower, sensitive to environmental stimuli, easily
Invasion and various stress factors by various pathogenic microorganisms are influenced.Suckling pig is relatively conventional with infectious diarrhea, and protects
Educate piglet with daily ration, environment, stress wait based on diarrhea caused by non-pathogenic factors.Relationship between these two types of factors is very close
It cuts, not only influenced each other, but also reciprocal causation, often infected in multiple infection or cross-mixing.
Grice diarrhoea has become a kind of important diseases for influencing pig breeding industry now, especially to the piglet being just born, one
Grice diarrhoea occurs for denier, and morbidity and mortality are all relatively high, and disease incidence is 50~80%, case fatality rate 80~100%.And
And the disease incidence of piglet diarrhoea was in up-trend in recent years, and the aetology and epidemiology of grice diarrhoea tend to be complicated, and one
A little new strains are separated, or even some mixed infections occur, also bring huge challenge to the prevention and control of the disease.
In recent years, with the extensive application of antibiotic and chemicals, antibody-resistant bacterium is generated, but also intestine of young pigs flora
Imbalance, therapeutic effect is poor, and medicament residue seriously endangers human health.In contrast, Chinese medicine and natural plant have
Noresidue, toxic side effect is small, is not likely to produce the advantages that drug resistance.Alkaloid, organic acid in Chinese medicine and natural plant at
Divide the duplication that can effectively inhibit virus, and gradually removes virus；Immunity can be improved in polysaccharide, component polypeptides, enhancing
Body's resistance to disease.Being equipped with the ingredients such as probiotics and antibacterial peptide can be improved curative effect simultaneously.Currently on the market for treating piglet abdomen
Most of tcm product rushed down is powder, and Product Process is coarse, seriously polluted, and curative effect is not easy to control, due to piglet gastrointestinal tract
Function is unsound, and the digestion and absorption for fibroid drug are poor, seriously affects the clinical efficacy of drug.
(3) summary of the invention
The object of the present invention is to provide a kind of compositions and preparation method thereof for preventing and treating grice diarrhoea, solve prior art work
The factors such as skill is simple, and Drug bioavailability is low, and quality is uncontrollable, and clinical efficacy is unstable.
In order to solve the above technical problems, the present invention provides a kind of composition and preparation method thereof for preventing and treating grice diarrhoea, institute
The raw material for stating composition indicates in parts by weight are as follows:
80~100 parts of climbing groundsel, 100~120 parts of chinaroot greenbrier, 80~100 parts of umbellate pore furgus, 100~120 parts of purslane, agkistrodon
80~100 parts of tongue grass, 280~400 parts of antibacterial peptide, 420~500 parts of glucose.
The composition the preparation method is as follows:
3 taste Chinese medicine of climbing groundsel, chinaroot greenbrier and purslane is taken, carries out ingredient according to parts by weight, puts into reactor tank, adds water clear
It washes three times, opens tapping valve, put cleaning solution, close tapping valve, add the water of 10~15 times of quality of medicinal material amounts to be dipped to medicinal material complete
After being impregnated with entirely, heating decocts secondary, 1~1.5 hour every time, filters while hot, collecting decoction is simultaneously concentrated under reduced pressure into relative density and is
1.15~1.20 clear cream is taken out and places room temperature, and adding ethyl alcohol to alcohol content is 70%, stirs evenly, stands overnight, and filters, filter
Liquid adds 2~3% active carbons to stir evenly, and stands overnight, and 10000~12000r/min is centrifuged online, and second is recovered under reduced pressure in supernatant
Alcohol to no alcohol taste, concentrate is placed 4 DEG C and is saved backup；2 taste Chinese medicine of umbellate pore furgus and oldenlandia diffusa is taken, is matched according to parts by weight
Material, is put into extraction tank, and water is added to clean three times, opens tapping valve, puts cleaning solution, closes tapping valve, add quality of medicinal material 10~
The water of 15 times of amounts are dipped to after medicinal material is impregnated with completely, and heating decocts secondary, and 1.5~2 hours every time, filtration, collecting decoction simultaneously subtracted
Pressure is concentrated into the clear cream that relative density is 1.20~1.25, takes out and places room temperature, and adding ethyl alcohol to alcohol content is 70%, and stirring is equal
It is even, it stands overnight, precipitating is taken to be dissolved in water, above-mentioned concentrate is added and is uniformly mixed, filtration, 170~180 DEG C of filtrate are spraying dry
It is dry, be added antibacterial peptide and glucose be uniformly mixed to get.
The present invention is showed for the Different types of etiopathogenises and its clinical symptoms of grice diarrhoea, right using the has a broad antifungal spectrum of antibacterial peptide
Gram-positive bacteria and Gram-negative bacteria all have killing effect, and also have certain killing effect to virus, and can mention
High immunity；Chinese medicine flavones, saponin component have effects that antibacterial, anti-inflammatory, polysaccharide component have effects that enhancing is immune,
It can achieve and inhibit harmful bacteria growth, diminish inflammation, enhance mucosal immunity；Glucose can be improved ability and supplement the work of body fluid
With each component compounding can treat grice diarrhoea, improve clinical symptoms.
(4) specific embodiment:
The present invention is described in further detail by following embodiment, but is not limited to the present embodiment.
Embodiment 1: a kind of composition and preparation method thereof for preventing and treating grice diarrhoea takes climbing groundsel 100g, chinaroot greenbrier
100g and purslane 100g is put into reactor tank, and water is added to clean three times, opens tapping valve, puts cleaning solution, closes tapping valve,
The water of 3000ml is added to be dipped to after medicinal material is impregnated with completely, heating decocts secondary, 1.5 hours every time, filters while hot, collecting decoction is simultaneously
It is concentrated under reduced pressure into the clear cream that relative density is 1.18, takes out and places room temperature, adding ethyl alcohol to alcohol content is 70%, stirs evenly, puts
It sets overnight, filtration, filtrate adds 2% active carbon to stir evenly, stands overnight, and 10000r/min is centrifuged online, and supernatant depressurizes back
Ethyl alcohol is received to no alcohol taste, concentrate is placed 4 DEG C and saved backup；Umbellate pore furgus 80g and oldenlandia diffusa 100g are taken, is put into extraction tank,
Add water to clean three times, open tapping valve, put cleaning solution, closes tapping valve, add the water of 2000ml to be dipped to medicinal material and be impregnated with completely
Afterwards, heating decocts secondary, and 2 hours every time, filtration, collecting decoction was simultaneously concentrated under reduced pressure into the clear cream that relative density is 1.25, takes out
Room temperature is placed, adding ethyl alcohol to alcohol content is 70%, stirs evenly, stands overnight, precipitating is taken to be dissolved in water, above-mentioned concentrate is added
It is uniformly mixed, filtration, filtrate is placed in spray dryer, and with intake air temperature for 175 DEG C, antibacterial peptide is added in spray drying
350g and glucose 550g is uniformly mixed to get composition one.
Embodiment 2: a kind of composition and preparation method thereof for preventing and treating grice diarrhoea takes climbing groundsel 100g, chinaroot greenbrier
120g and purslane 120g is put into reactor tank, and water is added to clean three times, opens tapping valve, puts cleaning solution, closes tapping valve,
The water of 4000ml is added to be dipped to after medicinal material is impregnated with completely, heating decocts secondary, 1.5 hours for the first time, second 1.2 hours, takes advantage of
Heat filtration, collecting decoction are simultaneously concentrated under reduced pressure into the clear cream that relative density is 1.16, take out and place room temperature, add ethyl alcohol to the alcohol content to be
70%, it stirs evenly, stands overnight, filter, filtrate adds 2.5% active carbon to stir evenly, stands overnight, and 10000r/min is online
Ethyl alcohol is recovered under reduced pressure to no alcohol taste in centrifugation, supernatant, and concentrate is placed 4 DEG C and saved backup；Take umbellate pore furgus 100g and oldenlandia diffusa
100g is put into extraction tank, and water is added to clean three times, opens tapping valve, puts cleaning solution, is closed tapping valve, is added the water of 2500ml
It is dipped to after medicinal material is impregnated with completely, heating decocts secondary, and 2 hours for the first time, second 1.5 hours, filtration, collecting decoction simultaneously subtracted
Pressure is concentrated into the clear cream that relative density is 1.22, takes out and places room temperature, and adding ethyl alcohol to alcohol content is 70%, is stirred evenly, and places
Overnight, it takes precipitating to be dissolved in water, above-mentioned concentrate is added and is uniformly mixed, filtration, filtrate is placed in spray dryer, with air inlet
Temperature is 180 DEG C, and antibacterial peptide 400g and glucose 490g is added in spray drying, is uniformly mixed to get composition two.
Illustrate the clinical efficacy of the composition of present invention prevention and treatment grice diarrhoea below by way of specific test example.
Weifang City, Shandong Province, pig farm, rice field town, 35~40 age in days piglets 100, since pig farm manages not in place, pig
Barnyard manure dirt fails to clean out in time, and along with temperature is hot, diarrhea situation occurs in piglet.Illness piglet speckles with waste from head to foot,
Draw canescence loose stools or faint yellow water sample loose stool, be mixed with and do not digest feed, anus is red and swollen, relaxation, defecation are frequent, anus, root of the tail,
Hind leg speckles with loose stool, spiritual depressed, poor appetite.Illness piglet is randomly divided into 4 groups, respectively composition one, group by overbit
Close object two, antibiotic control group and positive controls.Composition one and two test group of composition in feed per ton respectively by adding
The trial drug of 1kg, antibiotic control group press the colistine sulfate and Amoxicillin compound preparation that 1kg is added in material per ton,
Successive administration 5 days, positive controls did not added any drug in feed.Observe the death rate of each group test piglet, clinic is treated
Effect and changes of weight.
Curative effect determinate standard: excrement becomes strip or graininess from water sample loose stool after medication, and slack anus, has excrement at redness
Dirt disappearance, appetite, spirit switch to normally, and being discontinued in latter week without recurrence is to cure；After medication excrement by the retrogradation of water sample loose stool or
Become stack, anus redness mitigates, and it is effective that appetite, spirit, which make moderate progress,；The symptoms such as loose stool, appetite, spirit are without changing after medication
It is apt to be invalid.
Test result is shown in Tables 1 and 2.
1 clinical efficacy result of table
Note: lowercase difference indicates significant difference (P < 0.05).
Test result shows that compared with positive controls, composition of the invention can significantly improve facing for illness piglet
Bed symptom and reduction case fatality rate (P < 0.05), with antibiotic control group therapeutic equivalence.
2 changes of weight result of table
| Group | Before administration (kg) | After administration (kg) |
| One group of composition | 7.49±0.96 | 11.61±1.57b |
| Two groups of composition | 7.75±1.19 | 11.52±1.42b |
| Antibiotic control group | 7.56±1.61 | 10.73±1.33b |
| Positive controls | 7.59±1.02 | 9.19±1.42a |
Note: lowercase difference indicates significant difference (P < 0.05).
Test result shows that compared with positive controls, composition of the invention can improve illness intestine of young pigs problem,
Efficiency of feed utilization is improved, piglet weight gain, and significant difference (P < 0.05) are improved.
Above-mentioned test illustrates that Chinese medicine and antibacterial peptide components complement each other in composition of the invention, in prevention of diarrhea in piglets
Function of intestinal canal can be improved in disease, diarrhea rate is reduced, improve efficiency of feed utilization and improve piglet weight gain.Composition of the invention
Clinical effectiveness is suitable with antibiotic, can be very good to solve the problems, such as grice diarrhoea.
Claims (3)
1. a kind of composition and preparation method thereof for preventing and treating grice diarrhoea, it is characterized in that by climbing groundsel, chinaroot greenbrier, umbellate pore furgus, horse
Bitterroot, oldenlandia diffusa, antibacterial peptide and glucose group at, their parts by weight are as follows:
80~100 parts of climbing groundsel, 100~120 parts of chinaroot greenbrier, 80~100 parts of umbellate pore furgus, 100~120 parts of purslane, oldenlandia diffusa
80~100 parts, 280~400 parts of antibacterial peptide, 420~500 parts of glucose.
2. the composition and preparation method thereof of prevention and treatment grice diarrhoea according to claim 1, it is characterised in that preparation method
Are as follows: 3 taste Chinese medicine of climbing groundsel, chinaroot greenbrier and purslane is taken, carries out ingredient according to parts by weight, is put into reactor tank, water is added to clean three
Time, tapping valve is opened, cleaning solution is put, closes tapping valve, adds the water of 10~15 times of quality of medicinal material amounts to be dipped to medicinal material and soaks completely
Thoroughly after, heating decoct it is secondary, 1~1.5 hour every time, filter while hot, collecting decoction and be concentrated under reduced pressure into relative density be 1.15
~1.20 clear cream is taken out and places room temperature, and adding ethyl alcohol to alcohol content is 70%, stirs evenly, stands overnight, and is filtered, and filtrate adds 2
~3% active carbon stirs evenly, and stands overnight, and 10000~12000r/min is centrifuged online, and ethyl alcohol is recovered under reduced pressure to nothing in supernatant
Alcohol taste, concentrate are placed 4 DEG C and are saved backup；2 taste Chinese medicine of umbellate pore furgus and oldenlandia diffusa is taken, carries out ingredient according to parts by weight, is thrown
Enter in extractor, water is added to clean three times, open tapping valve, put cleaning solution, closes tapping valve, add 10~15 times of quality of medicinal material amounts
Water be dipped to after medicinal material is impregnated with completely, heating decocts secondary, and 1.5~2 hours every time, filtration, collecting decoction was simultaneously concentrated under reduced pressure
The clear cream for being 1.20~1.25 to relative density is taken out and places room temperature, and adding ethyl alcohol to alcohol content is 70%, is stirred evenly, and places
Overnight, it takes precipitating to be dissolved in water, above-mentioned concentrate is added and is uniformly mixed, filtration, 170~180 DEG C of filtrate spray drying are added anti-
Bacterium peptide and glucose be uniformly mixed to get.
3. the composition and preparation method thereof of any prevention and treatment grice diarrhoea stated according to claim 1~2, it is characterised in that can make
For at pulvis, oral solution, injection and granule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811024011.8A CN109381694A (en) | 2018-08-27 | 2018-08-27 | A kind of composition and preparation method thereof for preventing and treating grice diarrhoea |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811024011.8A CN109381694A (en) | 2018-08-27 | 2018-08-27 | A kind of composition and preparation method thereof for preventing and treating grice diarrhoea |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109381694A true CN109381694A (en) | 2019-02-26 |
Family
ID=65417549
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811024011.8A Pending CN109381694A (en) | 2018-08-27 | 2018-08-27 | A kind of composition and preparation method thereof for preventing and treating grice diarrhoea |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109381694A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102835609A (en) * | 2012-09-27 | 2012-12-26 | 山东新希望六和集团有限公司 | Pig feed capable of preventing piglets from diarrhea and traditional Chinese medicine composition |
| CN102919607A (en) * | 2012-11-14 | 2013-02-13 | 韶关金苹果饲料有限公司 | Chinese herbal medicine compound feed additive with anti-diarrhea function and improving pork quality |
| CN104857501A (en) * | 2015-06-08 | 2015-08-26 | 信阳农林学院 | Chinese and western medicine composition for treating piglet diarrhea and preparation method thereof |
| CN107744510A (en) * | 2017-10-25 | 2018-03-02 | 广东罗浮山国药股份有限公司 | A kind of preparation method of micro-pill type granule |
-
2018
- 2018-08-27 CN CN201811024011.8A patent/CN109381694A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102835609A (en) * | 2012-09-27 | 2012-12-26 | 山东新希望六和集团有限公司 | Pig feed capable of preventing piglets from diarrhea and traditional Chinese medicine composition |
| CN102919607A (en) * | 2012-11-14 | 2013-02-13 | 韶关金苹果饲料有限公司 | Chinese herbal medicine compound feed additive with anti-diarrhea function and improving pork quality |
| CN104857501A (en) * | 2015-06-08 | 2015-08-26 | 信阳农林学院 | Chinese and western medicine composition for treating piglet diarrhea and preparation method thereof |
| CN107744510A (en) * | 2017-10-25 | 2018-03-02 | 广东罗浮山国药股份有限公司 | A kind of preparation method of micro-pill type granule |
Non-Patent Citations (5)
| Title |
|---|
| 中华人民共和国卫生部药典委员会编: "《中华人民共和国药典 1977年版 一部》", 31 December 1978, 北京：人民卫生出版社 * |
| 何湘蓉等: "白花蛇舌草有效成分提取及抗菌作用研究", 《中兽医医药杂志》 * |
| 张静洁等: "抗菌肽对仔猪生长性能及降低腹泻率的影响", 《中国动物保健》 * |
| 曾晓霞等: "菝葜传统应用和现代研究概况", 《中草药》 * |
| 陆长青等: "千里光超微粉对仔猪腹泻的防治效果及对血清IgG、IgA和IgM的影响", 《广东农业科学》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101214311B (en) | Compound scutellaria injection for treating fowls and domestic animals infectious disease and preparation thereof | |
| CN105685476A (en) | Grouper feed and preparing method thereof | |
| CN102319297B (en) | Traditional Chinese veterinary medicine used for treating livestock, poultry and fish diseases | |
| CN101744924B (en) | Multiple-effect Chinese herbal medicine compound of bacterial diseases of turbot | |
| CN104208163B (en) | It is a kind of improve animal immunizing power Chinese veterinary medicinal composition, using and preparation method thereof | |
| CN107184702B (en) | Traditional Chinese medicine composition for preventing and treating proventriculitis and myogastritis of poultry and preparation method thereof | |
| CN104739960A (en) | Intestine and stomach antibacterial drug composition, and intestine and stomach antibacterial drug containing intestine and stomach antibacterial drug composition and preparation thereof | |
| CN104523897B (en) | A kind of enema medicament composition for treating piglet epidemic diarrhea | |
| CN103393778B (en) | Compound Chinese herbal preparation for preventing and treating fish bacteria and viral diseases | |
| CN106389717A (en) | Piglet drug-resistant colibacillosis treating traditional Chinese medicine composition | |
| CN101390965A (en) | Veterinary traditional Chinese herb medicine for treating livestock and poultry bacterial and viral infectious diseases and preparation method thereof | |
| CN109381694A (en) | A kind of composition and preparation method thereof for preventing and treating grice diarrhoea | |
| CN104825753B (en) | A kind of Chinese medicine composition for prevention newborn piglet diarrhea of being taken medicine by sow | |
| CN103800464B (en) | A kind of Chinese medicine composition for the treatment of yellow and white dysentery of piglet | |
| CN103720778A (en) | Medicine capable of supporting healthy energy and eliminating toxin | |
| CN101879238A (en) | Medicinal composition for preventing and controlling chicken colibacillosis and preparation method thereof | |
| CN102488767B (en) | Compound composition for treating bacterial diarrhoea of livestock and poultry | |
| CN102144706A (en) | Eucommia ulmoides extract feed additive and preparation method thereof | |
| CN101804135A (en) | Compound combined drug for treating poultry coccidiosis and preparation method thereof | |
| CN105250727A (en) | Traditional Chinese medicine composition for prevention and treatment of livestock diarrhea and preparation method of traditional Chinese medicine composition | |
| CN111990533A (en) | Fermented eucommia ulmoides leaf extract and application thereof in preparation of chicken feed | |
| CN105233250A (en) | Composite biological agent used for treating encephalopathy | |
| CN110755604A (en) | Pharmaceutical composition for preventing and treating poultry adenofibromyositis and application thereof | |
| CN104606627B (en) | A kind of pharmaceutical composition for treating grice diarrhoea and preparation method thereof | |
| CN109620877A (en) | Pure Chinese medicine fowl antibacterium disease preparation and preparation method thereof and application method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190226 |