CN109381393A - A kind of preparation facilities and preparation method of infant camellia suspension microcapsules soothing oil - Google Patents
A kind of preparation facilities and preparation method of infant camellia suspension microcapsules soothing oil Download PDFInfo
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- CN109381393A CN109381393A CN201811463567.7A CN201811463567A CN109381393A CN 109381393 A CN109381393 A CN 109381393A CN 201811463567 A CN201811463567 A CN 201811463567A CN 109381393 A CN109381393 A CN 109381393A
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/11—Encapsulated compositions
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/81—Preparation or application process involves irradiation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The present invention relates to the preparation facilities and preparation method of a kind of infant camellia suspension microcapsules soothing oil, including charging shunting zone, airflow channel, one-way gas flow valve, hard material, buffer area, fluid impact room, expansion flow tube area and stabilization area.The present invention uses gas jet mixing flow reaction chamber, suspension infant camellia microcapsules soothing oil is made in conjunction with low-temperature ultrasonic microwave cooperating Enzymatic Extraction, light fermentation-zymolysis technique and orifice microcapsules granulating technique, the product is rich in organic plant essence, infant's dry skin can be effectively improved, moisture and nutrition are provided, sebaceous glands is adjusted, is improved to skin allergy, redness, bubble, the therapeutic effect for dispelling red capillary and infant are to extraneous environmental resistance and other effects.
Description
Technical field
The present invention relates to the preparation facilities and preparation method of a kind of infant camellia suspension microcapsules soothing oil, belong to daily
Cosmetic technical field.
Background technique
With significantly improving for China's Living consumption, the consciousness of infantile health growth is constantly enhanced, Fu Mu
The expenditure investment of infant nursing product constantly increases, and is in urgent need and diversified, especially to moist with nutrition, nutrition is strong
Infant's soothing oil consumption demand of skin effect is increasingly vigorous, and market potential is huge.Infant's soothing oil has delaying skin thin
The effect of born of the same parents' water loss can preferably completely cut off the outside stimulus of dry environment, but that there are constituent structure is single, be practically free of
Water-soluble active ingredient can not carry out exogenous moisturizing, bad to treatment skin allergy, redness, bubble, red capillary and other effects
Situation.And creams class product artificial synthesized chemical emulsifier containing there are many easily produces infant's skin with maintaining product to stablize
Raw stimulation, or even influence the problem of working as infant's normal growth and development.Therefore it is directed to infant's skin feature, develops the peace of profession
Completely without stimulation, mild nutrition infant skin function, and it is effectively improved infant's dry skin, treats skin allergy, redness, water
The moisturizing skin care item of bubble, red capillary, become the research hotspot of China industry scientific research personnel.
Summary of the invention
The problems such as present invention is single for common soothing oil constituent, and effective component concentration is low ineffective, provides one
The preparation facilities and preparation method of kind infant camellia suspension microcapsules soothing oil.
The invention discloses a kind of preparation facilities of infant camellia suspension microcapsules soothing oil, including two chargings to shunt
Area, hard ram, buffer area, fluid impact room, expands flow tube area and stabilization area composition at airflow channel;The charging shunting zone
For the diadactic structure of symmetric parallel, the charging shunting zone is connected to by buffer area with fluid impact room, and the buffer area is in " Y "
Shape structure, the divergent ends of the buffer area are connected to two charging shunting zones respectively, the other end of the buffer area and institute
State the connection of fluid impact room;The airflow channel is connected to the side wall of the charging shunting zone;The hard ram is set to
Inside one end port that the charging shunting zone is connected with the buffer area;The inner wall of the fluid impact room is equipped with hard
Layer, intersection's inner wall of the buffer area are equipped with hard protrusion, and the hard protrusion and the hard layer surround reaction chamber, institute
The internal diameter for stating reaction chamber is less than the internal diameter of the buffer area;The reaction chamber is connected to by outlet valve with the expansion flow tube area.
The hard ram is set to the inside of the charging shunting zone at equal intervals, is formed between the hard ram
Micro channel;One end tapered structure of the hard ram far from the buffer area.
The inside of the airflow channel is equipped with fluid non-return valve.
A kind of preparation method of infant camellia suspension microcapsules soothing oil, which is characterized in that preparation step is as follows:
Air-dried camellia, pot marigold, honeysuckle, arnica are smashed it through 40 meshes, after mixing by step 1
It is added in distilled water, is heated to 60~65 DEG C, 30min is stirred in agitated kettle, be sufficiently mixed, then in 50~55 DEG C of ultrasounds
30~45min is handled in wave-microwave combination reaction kettle, wherein 1200~1500W of ultrasonic power, 25~40KHz of supersonic frequency, micro-
It is ultrasonic under the conditions of 1000~1200W of wave power, microwave frequency 2450MHz;Then reaction kettle cools the temperature to 40~45 DEG C, adjusts
Cellulase and pectinase enzymatic hydrolysis 3h is added to 5~5.5 in pH value, and enzymolysis liquid is centrifuged 10~15min under the conditions of 2500r/min,
Enzymatic hydrolysis clear liquid is taken, Sodium Hyaluronate, tea polyphenols is added, stirs, obtains naturally nourishing active constituent microactuator suspension glue
Capsule-core material;
Step 2 selects the one or more of maltodextrin, beta-cyclodextrin and fishskin gelatin, and being configured to mass concentration ratio is
2% solution, is added Angel dry ferment and papain is slightly fermented and digested, and obtains microcapsule wall material;
Step 3, will contain natural nourishing active constituent suspension microcapsules core material and wall material is separately added into two charging shunting zones
In, CO2Fluid under the control of fluid non-return valve through fluid channel into enter material and be sufficiently mixed;Liquid stream is in 200MPa high
Pressure is entered between the tiny hard ram of diameter, into buffer area in slightly buffer, subsequent two strands of high-velocity fluids into
Enter the sharp impacts into diameter tiny fluid impact room, and is entered through outlet valve and expand flow tube area, CO2Fluid start to gasify into
The secondary broken wall of row, discharges the effective component in core material further, wall material is further crushed, and obtains small point of high osmosis
Sub- state fusions;
Step 4 is granulated high osmosis small molecule state fusions using microcapsules prilling granulator, and shell nozzle is straight
Diameter is 2mm, nitrogen flow rate 50mL/s, vibration frequency 1200Hz, electrode tension 800V, and nozzle temperature is set as 45 DEG C;Thief zone
Property small molecule state fusions instilled in 4 DEG C of 0.2% genipin solution dropwise, mixing speed 500r/min, microcapsules solidification
Microcapsules distilled water flushing is poured into after draining and stirs 20min in camellia oil by 30min, stratification, and uniform microcapsule is outstanding
It floats in oil reservoir, remained on surface moisture sinks to lower layer, drains to obtain and nourishes active constituent suspension microcapsules containing natural;
Step 5 will contain functional activity ingredient fluid composition and fill together with active constituent suspension microcapsules with containing natural nourish
It is filled to and squeezes in dropper bottle to get infant's camellia suspension microcapsules soothing oil.
Wherein, the fluid composition of ingredient containing functional activity described in step 5 is by camellia seed oil, caprylic/capric glycerol three
Ester, natural saualane, jojoba oil, evening primrose oil, white awns flower seed oil, phytosterin ester, bisabolol, Vitwas E,
Vitamin A amyl acetate and the different palmitate of vitamin B6 three composition.
Compared with prior art, the beneficial effects of the present invention are:
(1) recovery rate of natural plant active component is improved, the permeability of small molecule state fusions is promoted, can also reduce
The loss of Heat sensitive active ingredient.
(2) present invention nourishes active constituent suspension microcapsules phase with containing natural using the fluid composition of ingredient containing functional activity
Mutual compatibility keeps product more gentle salubrious, assigns product and easily absorb, moisten and oiliness skin sense, and significant infant's skin of alleviating is done
It is dry coarse, moisture and nutrition are provided, sebaceous glands is adjusted, improves the treatment effect for dispelling red capillary to skin allergy, redness, bubble
Fruit improves infant to the resistivity of external environment, and the moist temperature for significantly improving camellia soothing oil supports effect.In addition, this hair
The bright stability that can significantly improve water-soluble active ingredient inhibits oxidation, and without adding emulsifier, it is total to can be achieved with grease
It deposits, reduces stimulation of the emulsifier to skin.
(3) present invention using ultrasonic-microwave collaboration enzyme process and light fermentation-zymolysis technique respectively to microcapsules core material and
Wall material carries out pre-treatment, and wall material is gently fermented through yeast effectively removes the fishy smell of fishskin gelatin in microcapsule wall material, papain
Yeast and fishskin gelatin are further digested, and reach minimum even state through gas jet mixing flow reaction unit, is significantly improved
Permeability.
Detailed description of the invention
Fig. 1 is a kind of structure chart of the preparation facilities of infant camellia suspension microcapsules soothing oil of the present invention;
Fig. 2 is infant camellia suspension microcapsules soothing oil outside drawing.
Specific embodiment
In order that those skilled in the art will better understand the technical solution of the present invention, below with reference to embodiment to this hair
Bright technical solution is described in further detail, and embodiments of the present invention are not limited thereto.
The invention discloses a kind of preparation facilities of infant camellia suspension microcapsules soothing oil, including two chargings to shunt
Area 1, hard ram 4, buffer area 5, fluid impact room 6, expands flow tube area 7 and the composition of stabilization area 8 at airflow channel 2;The charging
Shunting zone 1 is the diadactic structure of symmetric parallel, and the charging shunting zone 1 is connected to by buffer area 5 with fluid impact room 6, described
The structure in Y-shape of buffer area 5, the divergent ends of the buffer area 5 are connected to two charging shunting zones 1 respectively, the buffering
The other end in area 5 is connected to the fluid impact room 6;The airflow channel 2 is connected to the side wall of the charging shunting zone 1;Institute
Hard ram 4 is stated to be set to inside one end port that the charging shunting zone 1 is connected with the buffer area 5;The fluid is hit
The inner wall for hitting room 6 is equipped with hard layer, and intersection's inner wall of the buffer area 5 is equipped with hard protrusion, the hard protrusion with
The hard layer surrounds reaction chamber, and the internal diameter of the reaction chamber is less than the internal diameter of the buffer area 5;The reaction chamber passes through discharging
Valve 7 is connected to the expansion flow tube area 8, will contain it is natural nourish active constituent suspension microcapsules core material and wall material be separately added into two into
Expect in shunting zone 1, CO2Fluid under the control of fluid non-return valve 3 through fluid channel 2 into enter material and be sufficiently mixed;Liquid
Stream be entered under 200MPa high pressure between the tiny hard ram 4 of diameter, into buffer area 5 in slightly buffer, then should
Two strands of high-velocity fluids enter sharp impacts in the tiny fluid impact room 6 of diameter, and enter through outlet valve 7 and expand flow tube area 8,
CO2Fluid starts gasification and carries out secondary broken wall, discharges the effective component in core material further, wall material is further broken
It is broken, obtain high osmosis small molecule state fusions.
The hard ram 4 is set to the inside of the charging shunting zone 1 at equal intervals, between the hard ram 4
Form micro channel;One end tapered structure of the hard ram far from the buffer area 5, will contain it is natural nourish activity at
Divide suspension microcapsules core material and wall material tentatively to be dispersed by hard ram 4, keeps it more uniform.
The inside of the airflow channel 2 is equipped with fluid non-return valve 3, it is ensured that CO2Fluid will not nourish activity because of with natural
Hard ram 4 and reflux are hit in ingredient suspension microcapsules core material and wall material mixing.
A kind of preparation method of infant camellia suspension microcapsules soothing oil, steps are as follows:
Air-dried camellia, pot marigold, honeysuckle, arnica are smashed it through 40 meshes, after mixing by step 1
It is added in distilled water, is heated to 60~65 DEG C, 30min is stirred in agitated kettle, be sufficiently mixed, then in 50~55 DEG C of ultrasounds
30~45min is handled in wave-microwave combination reaction kettle, wherein 1200~1500W of ultrasonic power, 25~40KHz of supersonic frequency, micro-
It is ultrasonic under the conditions of 1000~1200W of wave power, microwave frequency 2450MHz;Then reaction kettle cools the temperature to 40~45 DEG C, adjusts
Cellulase and pectinase enzymatic hydrolysis 3h is added to 5~5.5 in pH value, and enzymolysis liquid is centrifuged 10~15min under the conditions of 2500r/min,
Enzymatic hydrolysis clear liquid is taken, Sodium Hyaluronate, tea polyphenols is added, stirs, obtains naturally nourishing active constituent microactuator suspension glue
Capsule-core material;
Step 2 selects the one or more of maltodextrin, beta-cyclodextrin and fishskin gelatin, and being configured to mass concentration ratio is
2% solution, is added Angel dry ferment and papain is slightly fermented and digested, and obtains microcapsule wall material;
Step 3, will contain natural nourishing active constituent suspension microcapsules core material and wall material is separately added into two charging shunting zones
In 1, CO2Fluid under the control of fluid non-return valve 3 through fluid channel 2 into enter material and be sufficiently mixed;Liquid stream exists
Be entered under 200MPa high pressure between the tiny hard ram 4 of diameter, into buffer area 5 in slightly buffer, then this two strands
High-velocity fluid enters sharp impacts in the tiny fluid impact room 6 of diameter, and enters through outlet valve 7 and expand flow tube area 8, CO2
Fluid starts gasification and carries out secondary broken wall, discharges the effective component in core material further, wall material is further crushed, and is obtained
To high osmosis small molecule state fusions;
Step 4 is granulated high osmosis small molecule state fusions using microcapsules prilling granulator, and nozzle diameter is
2mm, nitrogen flow rate 50mL/s, vibration frequency 1200Hz, electrode tension 800V, nozzle temperature are set as 45 DEG C;High osmosis is small
Molecular state fusions are instilled dropwise in 4 DEG C of 0.2% genipin solution, mixing speed 500r/min, and microcapsules solidify 30min,
It by microcapsules distilled water flushing, is poured into after draining and stirs 20min, stratification in camellia oil, uniform microcapsule is suspended in oil
In layer, remained on surface moisture sinks to lower layer, drains to obtain and nourishes active constituent suspension microcapsules containing natural;
Step 5 will contain functional activity ingredient fluid composition and fill together with active constituent suspension microcapsules with containing natural nourish
It is filled to and squeezes in dropper bottle to get infant's camellia suspension microcapsules soothing oil.
The fluid composition of ingredient containing functional activity described in the preparation step five of infant's camellia suspension microcapsules soothing oil
By camellia seed oil, caprylic/capric triglyceride, natural saualane, jojoba oil, evening primrose oil, white awns flower seed oil, phytosterol
Ester, bisabolol, Vitwas E, vitamin A amyl acetate and the different palmitate of vitamin B6 three composition.
Embodiment one:
The present embodiment provides a kind of preparation method of infant camellia suspension microcapsules soothing oil, preparation step is as follows:
Air-dried camellia, pot marigold, honeysuckle, arnica are smashed it through 40 meshes, accurately weigh mountain by step 1
Camellia 0.4kg, pot marigold 0.4kg, honeysuckle 0.4kg, arnica 0.2kg, are added to after mixing in 50kg distilled water,
60~65 DEG C are heated to, 30min is stirred in agitated kettle, is sufficiently mixed, then anti-in 50~55 DEG C of ultrasonic-microwave combinations
Answer in kettle 30~45min of processing, wherein 1200~1500W of ultrasonic power, 25~40KHz of supersonic frequency, microwave power 1000~
It is ultrasonic under the conditions of 1200W, microwave frequency 2450MHz;Then reaction kettle cools the temperature to 40~45 DEG C, adjust pH value to 5~
5.5, cellulase and pectinase enzymatic hydrolysis 3h is added, enzymolysis liquid is centrifuged 10~15min under the conditions of 2500r/min, takes enzymatic hydrolysis clear
Liquid adds Sodium Hyaluronate, tea polyphenols, stirs, and obtains naturally nourishing active constituent suspension microcapsules core material;
The maltodextrin of 0.5kg and 0.5kg fishskin gelatin are added in 60 DEG C of distilled water of 50kg by step 2, stirring
To being completely dissolved, temperature is reduced to 38 DEG C, pH is adjusted to 6.0, and 200g Angel dry ferment is added and continues to stir 1h to carry out gently
Degree fermentation, adds 200g papain and digests 2h gently to get microcapsule wall material.
Step 3, will contain natural nourishing active constituent suspension microcapsules core material and wall material is separately added into gas jet mixing flow reaction chamber
Two charging shunting zones in, the CO of 10kg2Fluid enters under the control of one-way gas flow valve through airflow channel to carry out with material
It is sufficiently mixed;Liquid stream is entered in the tiny hard material of diameter under 200MPa high pressure, into buffer area in slightly buffer, with
Two strands of high-velocity fluids enter sharp impacts in the tiny fluid impact reaction chamber of diameter afterwards, and enter expansion flow tube area and let out
Pressure, CO2Fluid starts gasification and carries out secondary broken wall, discharges the effective component in core material further, wall material is further
It is broken, obtain high osmosis small molecule state fusions;
Step 4 is granulated high osmosis small molecule state fusions using microcapsules prilling granulator, and shell nozzle is straight
Diameter is 2mm, nitrogen flow rate 50mL/s, vibration frequency 1200Hz, electrode tension 800V, and nozzle temperature is set as 45 DEG C;Thief zone
Property small molecule state fusions instilled in 4 DEG C of 0.2% genipin solution dropwise, mixing speed 500r/min, microcapsules solidification
Microcapsules distilled water flushing is poured into after draining and stirs 20min in camellia oil by 30min, stratification, and uniform microcapsule is outstanding
It floats in oil reservoir, remained on surface moisture sinks to lower layer, drains to obtain and nourishes active constituent suspension microcapsules containing natural;
Step 5 will contain functional activity ingredient fluid composition and contain the natural active constituent suspension microcapsules that nourish by 5:5
Weight ratio together it is filling to squeeze dropper bottle in get infant's camellia suspension microcapsules soothing oil.
Wherein, the fluid composition of ingredient containing functional activity described in step 5 is by camellia seed oil 55kg, caprylic/capric glycerol
Three ester 25kg, natural saualane 8.5kg, jojoba oil 3kg, evening primrose oil 3kg, white awns flower seed oil 3kg, phytosterin ester
0.4kg, bisabolol 0.4kg, Vitwas E 1.2kg, vitamin A amyl acetate 0.25kg, the different palmitinic acid of vitamin B6 three
Ester 0.25kg is uniformly mixed composition.
Embodiment two:
The present embodiment provides a kind of preparation method of infant camellia suspension microcapsules soothing oil, preparation step is as follows:
Air-dried camellia, pot marigold, honeysuckle, arnica are smashed it through 40 meshes, accurately weigh mountain by step 1
Camellia 0.4kg, pot marigold 0.4kg, honeysuckle 0.4kg, arnica 0.2kg, are added to after mixing in 50kg distilled water,
60~65 DEG C are heated to, 30min is stirred in agitated kettle, is sufficiently mixed, then anti-in 50~55 DEG C of ultrasonic-microwave combinations
Answer in kettle 30~45min of processing, wherein 1200~1500W of ultrasonic power, 25~40KHz of supersonic frequency, microwave power 1000~
It is ultrasonic under the conditions of 1200W, microwave frequency 2450MHz;Then reaction kettle cools the temperature to 40~45 DEG C, adjust pH value to 5~
5.5, cellulase and pectinase enzymatic hydrolysis 3h is added, enzymolysis liquid is centrifuged 10~15min under the conditions of 2500r/min, takes enzymatic hydrolysis clear
Liquid adds Sodium Hyaluronate, tea polyphenols, stirs, and obtains naturally nourishing active constituent suspension microcapsules core material;
The maltodextrin of 0.5kg and 0.5kg fishskin gelatin are added in 60 DEG C of distilled water of 50kg by step 2, stirring
To being completely dissolved, temperature is reduced to 38 DEG C, pH is adjusted to 6.0, and 200g Angel dry ferment is added and continues to stir 1h to carry out gently
Degree fermentation, adds 200g papain and digests 2h gently to get microcapsule wall material.
Step 3, will contain natural nourishing active constituent suspension microcapsules core material and wall material is added in agitated kettle and stirs
30min carries out microjet processing to it under 200MPa high pressure, obtains microcapsule polymer.
Step 4 is granulated microcapsule polymer using microcapsules prilling granulator, nozzle diameter 2mm, nitrogen stream
Fast 50mL/s, vibration frequency 1200Hz, electrode tension 800V, nozzle temperature are set as 45 DEG C;Microcapsule polymer instills 4 dropwise
DEG C 0.2% genipin solution in, mixing speed 500r/min, microcapsules solidify 30min, by microcapsules distilled water flushing,
It is poured into after draining and stirs 20min, stratification in camellia oil, uniform microcapsule is suspended in oil reservoir, and remained on surface moisture is sunk to
Lower layer drains to obtain and nourishes active constituent suspension microcapsules containing natural;
Step 5 will contain functional activity ingredient fluid composition and contain the natural active constituent suspension microcapsules that nourish by 5:5
Weight ratio together it is filling to squeeze dropper bottle in get infant's camellia suspension microcapsules soothing oil.
Wherein, the fluid composition of ingredient containing functional activity described in step 5 is by camellia seed oil 55kg, caprylic/capric glycerol
Three ester 25kg, natural saualane 8.5kg, jojoba oil 3kg, evening primrose oil 3kg, white awns flower seed oil 3kg, phytosterin ester
0.4kg, bisabolol 0.4kg, Vitwas E 1.2kg, vitamin A amyl acetate 0.25kg, the different palmitinic acid of vitamin B6 three
Ester 0.25kg is uniformly mixed composition.
Embodiment three:
The present embodiment provides a kind of preparation method of infant camellia suspension microcapsules soothing oil, preparation step is as follows:
Air-dried camellia, pot marigold, honeysuckle, arnica are smashed it through 40 meshes, accurately weigh mountain by step 1
Camellia 0.4kg, pot marigold 0.4kg, honeysuckle 0.4kg, arnica 0.2kg, are added to after mixing in 50kg distilled water,
60~65 DEG C are heated to, 30min is stirred in agitated kettle, is sufficiently mixed, then anti-in 50~55 DEG C of ultrasonic-microwave combinations
Answer in kettle 30~45min of processing, wherein 1200~1500W of ultrasonic power, 25~40KHz of supersonic frequency, microwave power 1000~
It is ultrasonic under the conditions of 1200W, microwave frequency 2450MHz;Then reaction kettle cools the temperature to 40~45 DEG C, adjust pH value to 5~
5.5, cellulase and pectinase enzymatic hydrolysis 3h is added, enzymolysis liquid is centrifuged 10~15min under the conditions of 2500r/min, takes enzymatic hydrolysis clear
Liquid adds Sodium Hyaluronate, tea polyphenols, stirs, and obtains naturally nourishing active constituent suspension microcapsules core material;
The maltodextrin of 0.5kg and 0.5kg fishskin gelatin are added in 60 DEG C of distilled water of 50kg by step 2, stirring
To being completely dissolved, temperature is reduced to 38 DEG C, pH is adjusted to 6.0, and 200g Angel dry ferment is added and continues to stir 1h to carry out gently
Degree fermentation, adds 200g papain and digests 2h gently to get microcapsule wall material.
Step 3 is granulated microcapsule polymer using microcapsules prilling granulator, core wall ratio 1:1 is controlled, with same
The heart circle apologizes, core nozzle diameter be 1mm, shell nozzle diameter be 2mm, nitrogen flow rate 50mL/s, vibration frequency 1200Hz,
Electrode tension 800V, nozzle temperature are set as 45 DEG C;It is instilled in 4 DEG C of 0.2% genipin solution dropwise, mixing speed 500r/
Microcapsules distilled water flushing is poured into after draining and stirs 20min in camellia oil, stood and divide by min, microcapsules solidification 30min
Layer, uniform microcapsule are suspended in oil reservoir, and remained on surface moisture sinks to lower layer, are drained to obtain and are nourished active constituent suspension containing natural
Microcapsules;
Step 5 will contain functional activity ingredient fluid composition and contain the natural active constituent suspension microcapsules that nourish by 5:5
Weight ratio together it is filling to squeeze dropper bottle in get infant's camellia suspension microcapsules soothing oil.
Wherein, the fluid composition of ingredient containing functional activity described in step 5 is by camellia seed oil 55kg, caprylic/capric glycerol
Three ester 25kg, natural saualane 8.5kg, jojoba oil 3kg, evening primrose oil 3kg, white awns flower seed oil 3kg, phytosterin ester
0.4kg, bisabolol 0.4kg, Vitwas E 1.2kg, vitamin A amyl acetate 0.25kg, the different palmitinic acid of vitamin B6 three
Ester 0.25kg is uniformly mixed composition.
1 infant's camellia suspension microcapsules soothing oil sensory evaluation criteria of table
The measurement result of table 2 product physical and chemical index and sensory evaluation scores value
Learn that the sensory evaluation of 1 product of embodiment is best by the measurement result analysis of the sensory evaluation scores value of 2 product of table.?
In embodiment 1, microcapsules core material has used low-temperature ultrasonic microwave cooperating Enzymatic Extraction, and microcapsule wall material takes light fermentation-
Enzymolysis processing, and microcapsules core material and wall material are processed into high osmosis small molecule state fusions with gas jet mixing flow reaction chamber,
Product odour faint scent is pleasant, and texture is more slim and graceful smooth after smearing, significantly improves the absorbability of microcapsules and the taste to skin
Humidity.In example 2, microcapsules core material and wall material have only carried out common microjet processing, and common microjet is to material
Percentage of damage is low, material particular diameter is big, leads to microcapsules absorbability and is declined to the permeability of skin.3 product of embodiment by
Traditional handicraft preparation, microcapsules are difficult to penetrate into the macromolecular of skin, absorbability and the moist degree to skin in the presence of many
Obvious to weaken, quality is more thick and heavy, and spreadability is general.As it can be seen that low-temperature ultrasonic microwave cooperating Enzymatic Extraction, super-pressure are overcritical
Micro jetting technology, light fermentation-zymolysis technique, orifice microcapsules granulating technique is indispensable, to infant's camellia suspension microcapsules
The preparation of soothing oil plays the role of conspicuousness.
It is above only several specific preferred embodiments of the invention, it should be understood that these embodiments are merely to illustrate the present invention
Rather than limit the scope of the invention, after the present invention has been read, those skilled in the art are to various equivalences of the invention
The modification of form fall within the present invention it is as defined in the appended claims, protection scope of the present invention should be wanted with right of the invention
It asks.
The above description is only an embodiment of the present invention, is not intended to limit the scope of the invention, it should be noted that
Such as there is term " on ", "lower", "left", "right" " top ", " bottom ", "vertical", "horizontal", "inner", "outside", indicated by
Orientation or positional relationship be based on the orientation or positional relationship shown in the drawings, be merely for convenience of description the present invention and simplification retouch
It states, rather than the device or element of indication or suggestion meaning must have a particular orientation, be constructed and operated in a specific orientation,
Therefore it is not considered as limiting the invention.In addition, such as there is term " first ", " second ", " third " are only used for description mesh
, it is not understood to indicate or imply relative importance.In the description of the present invention, it should be noted that unless otherwise bright
, such as there is term " installation ", " connected ", " connection " shall be understood in a broad sense in true regulation and restriction, for example, it may be fixed connect
It connects, may be a detachable connection, or the connection of one;It can be mechanical connection, be also possible to be electrically connected;It can be direct phase
Even, the connection inside two elements can also be can be indirectly connected through an intermediary.For the ordinary skill people of this field
For member, the concrete meaning of above-mentioned term in the present invention can be understood with concrete condition, it is all using description of the invention and attached
Equivalents made by figure content are applied directly or indirectly in relevant technical field, similarly include in patent of the invention
In protection scope.
Claims (5)
1. a kind of preparation facilities of infant camellia suspension microcapsules soothing oil, it is characterised in that: including two charging shunting zones
(1), airflow channel (2), hard ram (4), buffer area (5), fluid impact room (6), expansion flow tube area (7) and stabilization area (8)
It constitutes;Charging shunting zone (1) is the diadactic structure of symmetric parallel, and the charging shunting zone (1) passes through buffer area (5) and stream
Body impact room (6) connection, the buffer area (5) structure in Y-shape, the divergent ends of the buffer area (5) are respectively and described in two
Shunting zone (1) connection is fed, the other end of the buffer area (5) is connected to the fluid impact room (6);The airflow channel
(2) it is connected to the side wall of charging shunting zone (1);The hard ram (4) is set to the charging shunting zone (1) and institute
It states inside buffer area (5) connected one end port;The inner wall of the fluid impact room (6) is equipped with hard layer, the buffer area
(5) intersection's inner wall is equipped with hard protrusion, and the hard protrusion and the hard layer surround reaction chamber, the reaction chamber
Internal diameter is less than the internal diameter of the buffer area (5);The reaction chamber is connected to by outlet valve (7) with the expansion flow tube area (8).
2. a kind of preparation facilities of infant camellia suspension microcapsules soothing oil according to claim 1, it is characterised in that:
The hard ram (4) is set to the inside of charging shunting zone (1), shape between the hard ram (4) at equal intervals
At micro channel;One end tapered structure of the hard ram far from the buffer area (5).
3. a kind of preparation facilities of infant camellia suspension microcapsules soothing oil according to claim 2, it is characterised in that:
The inside of the airflow channel (2) is equipped with fluid non-return valve (3).
4. a kind of preparation method of infant camellia suspension microcapsules soothing oil, which is characterized in that steps are as follows:
Air-dried camellia, pot marigold, honeysuckle, arnica are smashed it through 40 meshes, are added after mixing by step 1
In distilled water, 60~65 DEG C are heated to, 30 min are stirred in agitated kettle, are sufficiently mixed, then in 50~55 DEG C of ultrasonic waves-
30~45 min are handled in microwave combination reaction kettle, wherein 1200~1500 W of ultrasonic power, 25~40 KHz of supersonic frequency, micro-
It is ultrasonic under the conditions of 1000~1200 W of wave power, 2450 MHz of microwave frequency;Then reaction kettle cools the temperature to 40~45 DEG C, adjusts
PH value is saved to 5~5.5, cellulase and 3 h of pectinase enzymatic hydrolysis is added, enzymolysis liquid is centrifuged 10~15 under the conditions of 2500 r/min
Min takes enzymatic hydrolysis clear liquid, adds Sodium Hyaluronate, tea polyphenols, stirs, and obtains naturally nourishing active constituent suspension
Microcapsules core material;
Step 2 selects the one or more of maltodextrin, beta-cyclodextrin and fishskin gelatin, and being configured to mass concentration ratio is 2%
Solution, is added Angel dry ferment and papain is slightly fermented and digested, and obtains microcapsule wall material;
Step 3, will contain natural nourishing active constituent suspension microcapsules core material and wall material is separately added into two charging shunting zones (1)
In, CO2Fluid under the control of fluid non-return valve (3) through fluid channel (2) into enter material and be sufficiently mixed;Liquid stream exists
It is entered under 200 MPa high pressures between the tiny hard ram (4) of diameter, slightly buffers into buffer area (5) are interior, then should
Two strands of high-velocity fluids enter sharp impacts in the tiny fluid impact room (6) of diameter, and enter expansion flow tube through outlet valve (7)
Area (8), CO2Fluid starts gasification and carries out secondary broken wall, discharges the effective component in core material further, and wall material is into one
Step is broken, obtains high osmosis small molecule state fusions;
Step 4 is granulated high osmosis small molecule state fusions using microcapsules prilling granulator, and nozzle diameter is 2 mm,
50 mL/s of nitrogen flow rate, 1200 Hz of vibration frequency, 800 V of electrode tension, nozzle temperature are set as 45 DEG C;High osmosis is small
Molecular state fusions are instilled dropwise in 4 DEG C of 0.2% genipin solution, 500 r/min of mixing speed, microcapsules solidification 30
Microcapsules distilled water flushing is poured into camellia oil after draining and stirs 20 min by min, stratification, and uniform microcapsule suspends
In oil reservoir, remained on surface moisture sinks to lower layer, drains to obtain and nourishes active constituent suspension microcapsules containing natural;
Step 5, will contain functional activity ingredient fluid composition with containing it is natural nourish together with active constituent suspension microcapsules it is filling extremely
It squeezes in dropper bottle to get infant's camellia suspension microcapsules soothing oil.
5. a kind of gas jet mixing flow reaction chamber according to claim 4 and its be used to prepare infant's camellia suspension microcapsules profit
The method of skin oil, which is characterized in that containing functional living described in the preparation step five of infant's camellia suspension microcapsules soothing oil
Property ingredient fluid composition is by camellia seed oil, caprylic/capric triglyceride, natural saualane, jojoba oil, evening primrose oil, Bai Mang
Flower seed oil, phytosterin ester, bisabolol, Vitwas E, vitamin A amyl acetate and the different palmitate of vitamin B6 three
Composition.
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN112354651A (en) * | 2020-11-16 | 2021-02-12 | 南昌大学 | Jet impact grinding equipment and method for food full-component pulping |
CN115176947A (en) * | 2022-07-15 | 2022-10-14 | 广西壮族自治区农业科学院 | Preparation method of self-stable red-core pitaya whole pulp |
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FR2997299A1 (en) * | 2012-10-30 | 2014-05-02 | Sederma Sa | ASSOCIATION OF PLANT EXTRACTS, COSMETIC ACTIVE INGREDIENT AND COMPOSITION CONTAINING THE SAME, AND COSMETIC TOPICAL USE |
CN107308044A (en) * | 2017-06-29 | 2017-11-03 | 湖南大三湘油茶生态产业有限公司 | Infant's anti-inflammatory antiallergic camellia soothing oil and preparation method thereof |
CN108653013A (en) * | 2018-06-28 | 2018-10-16 | 芜湖扬展新材料科技服务有限公司 | A kind of plant moisturizing water profit after-sun frost and preparation method thereof |
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Patent Citations (3)
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FR2997299A1 (en) * | 2012-10-30 | 2014-05-02 | Sederma Sa | ASSOCIATION OF PLANT EXTRACTS, COSMETIC ACTIVE INGREDIENT AND COMPOSITION CONTAINING THE SAME, AND COSMETIC TOPICAL USE |
CN107308044A (en) * | 2017-06-29 | 2017-11-03 | 湖南大三湘油茶生态产业有限公司 | Infant's anti-inflammatory antiallergic camellia soothing oil and preparation method thereof |
CN108653013A (en) * | 2018-06-28 | 2018-10-16 | 芜湖扬展新材料科技服务有限公司 | A kind of plant moisturizing water profit after-sun frost and preparation method thereof |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN112354651A (en) * | 2020-11-16 | 2021-02-12 | 南昌大学 | Jet impact grinding equipment and method for food full-component pulping |
CN112354651B (en) * | 2020-11-16 | 2022-03-11 | 南昌大学 | Jet impact grinding equipment and method for food full-component pulping |
CN115176947A (en) * | 2022-07-15 | 2022-10-14 | 广西壮族自治区农业科学院 | Preparation method of self-stable red-core pitaya whole pulp |
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