CN109358101A - A kind of electrochemical sensor electrodes test piece of multi-parameter detection - Google Patents
A kind of electrochemical sensor electrodes test piece of multi-parameter detection Download PDFInfo
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- CN109358101A CN109358101A CN201811010743.1A CN201811010743A CN109358101A CN 109358101 A CN109358101 A CN 109358101A CN 201811010743 A CN201811010743 A CN 201811010743A CN 109358101 A CN109358101 A CN 109358101A
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- 238000012360 testing method Methods 0.000 title claims abstract description 44
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- 230000006870 function Effects 0.000 description 10
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- 230000007812 deficiency Effects 0.000 description 4
- 239000008103 glucose Substances 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
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- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 3
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 229940005267 urate oxidase Drugs 0.000 description 3
- 229940116269 uric acid Drugs 0.000 description 3
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- 102000004190 Enzymes Human genes 0.000 description 2
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- 108010015776 Glucose oxidase Proteins 0.000 description 2
- 239000004366 Glucose oxidase Substances 0.000 description 2
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- 239000004310 lactic acid Substances 0.000 description 2
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- 210000002700 urine Anatomy 0.000 description 2
- 101710128063 Carbohydrate oxidase Proteins 0.000 description 1
- 108010089254 Cholesterol oxidase Proteins 0.000 description 1
- 101710088194 Dehydrogenase Proteins 0.000 description 1
- 108010050375 Glucose 1-Dehydrogenase Proteins 0.000 description 1
- 102000017011 Glycated Hemoglobin A Human genes 0.000 description 1
- 108010014663 Glycated Hemoglobin A Proteins 0.000 description 1
- 102000003855 L-lactate dehydrogenase Human genes 0.000 description 1
- 102000003992 Peroxidases Human genes 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/27—Association of two or more measuring systems or cells, each measuring a different parameter, where the measurement results may be either used independently, the systems or cells being physically associated, or combined to produce a value for a further parameter
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
- G01N27/3272—Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels
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- Chemical & Material Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
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Abstract
The invention discloses a kind of electrochemical sensor electrodes test piece of multi-parameter detection, including substrate and electrode group, electrode group includes at least working electrode and auxiliary electrode, is respectively provided with an electrode group in the opposite both ends of the surface of substrate.The present invention provides one kind can be carried out multi-parameter detection, improves the electrochemical sensor electrodes test piece of the utilization rate of electrode test piece.
Description
Technical field
The present invention relates to electrochemical fields, more specifically, it is related to a kind of electrochemical sensor electricity of multi-parameter detection
Pole test piece.
Background technique
It is widely used using electrochemica biological sensor as the electrochemical test bar of principle in detection field (POCT) immediately.
Physiological fluid such as blood, sweat, contain the interested detection parameters of many clinical labororatories in saliva at urine, such as in blood
Glucose, cholesterol, glycosylated hemoglobin, blood ketone, the uric acid in urine, the lactic acid etc. in sweat.And these detection parameters
With the demand often detected.Currently, common commercialization electrochemical test bar only one reaction chamber, and measurement every time mostly
It is only capable of detecting one-component.One bleed or one drop sample to be tested liquid can only detect a kind of parameter.
Summary of the invention
The purpose of the present invention is to provide one kind can be carried out multi-parameter detection, improves the electrochemistry of the utilization rate of electrode test piece
Sensor electrode test piece.
The technical solution adopted by the present invention to solve the technical problems is: a kind of electrochemical sensor electricity of multi-parameter detection
Pole test piece, including substrate and electrode group, electrode group include at least working electrode and auxiliary electrode, each in the opposite both ends of the surface of substrate
Equipped with an electrode group.
As a preferred option, substrate two sides are respectively provided with an electrode group.
As a preferred option, in the opposite both ends of the surface of substrate and two sides are respectively provided with a recognition terminal, identify end
Son is between working electrode and auxiliary electrode.
As a preferred option, each electrode group also has reference electrode.Working electrode and auxiliary electrode formation detect back
Road generates electric current and captures the concentration that electric signal is converted into sample to be tested again.Working electrode and reference electrode constitute one it is obstructed or
Substantially the system being powered less measures the electrode potential of working electrode using the stability of reference electrode current potential.Preferably, electric grade
Group further includes detecting electrode.Detecting electrode has short-circuit self-checking function or is loaded insufficient detection function, if detecting electrode has
When short-circuit self-checking function, i.e., when test strips are inserted into detector, it is short for judging if the test paper is used or short-circuit
Road can not continue to use.If detecting electrode has sample-adding deficiency detection function, when the sample to be tested that test strips are added is insufficient
When, instrument can then show that sample-adding amount deficiency need to mend additional sample to be tested amount at the appointed time and can accurately test.The electrification
Learning sensor electrode test piece can be in response to the different number of electrode of electrochemical action demand difference collocation.
As a preferred option, electrode group has electrode terminal, conducting part and a reacting part, electrode terminal, conducting part and anti-
Portion is answered to be sequentially connected.
As a preferred option, the reacting part of working electrode and auxiliary electrode is bent in opposite directions.
As a preferred option, substrate two sides are respectively provided with detection slot, and reactive site is in detection slot and exposing to detection
Slot.
As a preferred option, the both ends of the surface of the substrate and two sides are equipped with siphon cover board.
The present invention has the advantages that
1, by the way that electrode group is arranged in the front and back sides of substrate, the working electrode in electrode group can modify different bioids
Reagent is learned to detect different samples to be tested, or multi-parameter detection can be carried out simultaneously and increased without repeated acquisition sample
The diversity of test.
2, electrode group is set in the two sides of substrate, the two sides of substrate can detecte different samples to be tested, increase
The diversity of test.
3, four end faces of substrate can detecte sample to be tested, can detect four kinds of different samples to be tested simultaneously, or
Person carries out the detection of four kinds of parameters to a kind of sample to be tested.
4, for same sample, front and back sides, the two sides of electrode test piece can quickly be detected to obtain testing result, just
In comparative analysis detection data, the complexity of detection is effectively reduced, improves the accuracy of detection.
5, electrochemical electrode test piece is made to the multi-parameter detecting electrode test piece of polyhedral structure, improves the benefit of electrode test piece
With rate, the cost of manufacture of electrode test piece is reduced.
Detailed description of the invention
Fig. 1 is the structural diagram of the present invention.
Fig. 2 is the front view of electrode test piece.
Fig. 3 is the sectional view along A-A in Fig. 2.
It is identified in figure: substrate 1, detection slot 11, working electrode 21, auxiliary electrode 22, electrode terminal 212, conducting part 213,
Reacting part 211, reference electrode 23, recognition terminal 24, siphon cover board 25.
Specific embodiment
The present invention is further described with reference to the accompanying drawings and detailed description.
Embodiment 1
As depicted in figs. 1 and 2, a kind of electrochemical sensor electrodes test piece of multi-parameter detection, including substrate 1 and electrode
Group, electrode group include at least working electrode 21 and auxiliary electrode 22, and electrode group is located on two opposite end faces of substrate 1.Work
Electrode 21 and auxiliary electrode 22 form measure loop, generate electric current and capture the concentration that electric signal is converted into sample to be tested again.Relatively
Two end faces refer to the obverse and reverse of substrate 1.Different biochemistries can be modified for front and back sides working electrode test piece
Reagent tests different samples, increases the diversity of test.Without repeated acquisition sample, realize that a kind of sample is two-parameter
Detection.
As shown in Figure 1, opposite two end faces of substrate 1 refer to that the obverse and reverse of substrate 1, obverse and reverse are respectively provided with one
A electrode group.Working electrode 21 and auxiliary electrode 22 form measure loop, generate electric current capture electric signal and are converted into again to test sample
This concentration.
As shown in Figure 1, electrode group further includes reference electrode 23.Working electrode 21 and reference electrode 23 constitute one it is obstructed or
Substantially the system being powered less measures the electrode potential of working electrode using the stability of 23 current potential of reference electrode.Preferably, electric
Pole group further includes detecting electrode.Detecting electrode has short-circuit self-checking function or is loaded insufficient detection function, if detecting electrode has
When having short-circuit self-checking function, i.e., when test strips be inserted into detector when, judged if the test paper is used or short-circuit for
Short circuit can not continue to use.If detecting electrode has sample-adding deficiency detection function, when the sample to be tested that test strips are added is insufficient
When, instrument can then show that sample-adding amount deficiency need to mend additional sample size at the appointed time and can accurately test.The electrochemistry passes
Sensor electrode test piece can be in response to the different number of electrode of electrochemical action demand difference collocation.
As one embodiment, the working electrode 21 in the both ends of the surface of substrate 1 is drawn by respective conducting wire, auxiliary electrode 22
Parallel connection, 22 parallel connection of auxiliary electrode refer to that the auxiliary electrode in 1 both ends of the surface of substrate can share a conducting wire, auxiliary electrode 22 with appoint
What working electrode 21 may be constructed measure loop.
As a specific embodiment, two end faces of substrate 1 are equipped with recognition terminal 24, and recognition terminal 24 is located at work
Make between electrode 21 and auxiliary electrode 22, as shown in Figure 2.One and only one recognition terminal 24 of each end face and it is neighbouring it
One electrode terminal has electrical connection, to achieve the effect that identification.For example, recognition terminal 24 is only electric with adjacent working electrode 21
Gas connection.
As a specific embodiment, as shown in Fig. 2, two end faces of the substrate 1 are equipped with siphon cover board 25.Institute
It states siphon cover board 25 and pastes two end faces for being covered in the substrate 1 respectively.The siphon cover board 25 is pasted by insulating materials
It is covered in hydrophilic film and is made, gap is equipped among insulating materials, forming straight channels is capillary diversion channel.
As one embodiment, as shown in Fig. 2, electrode group further includes reference electrode 23, working electrode 21, auxiliary electrode 22
It is arranged successively with reference electrode 23.Electrode group all has electrode terminal 212, conducting part 213 and reacting part 211, electrode terminal
212, conducting part 213 and reacting part 211 are sequentially connected, i.e., working electrode 21, auxiliary electrode 22 and reference electrode 23 all have
Electrode terminal 212, conducting part 213 and reacting part 211.As a preferred option, the reaction of working electrode 21 and auxiliary electrode 22
Portion 211 is bent in opposite directions, and opposite bending facilitates detection.
As a specific embodiment, the positive working electrode 21 of substrate 1, auxiliary electrode 22, recognition terminal 24, ginseng
Than the working electrode 21 of electrode 23 and reverse side, auxiliary electrode 22, recognition terminal 23, reference electrode 23 put in order on the contrary, with
Have the function that positive-negative connected can work normally.
The working electrode 21 being capable of modified biological chemical reagent.The biological chemical reagent can aoxidize for glucose
It is enzyme, mutarotase, glucose dehydrogenase, lactate oxidase, urate oxidase, cholesterol oxidase, phosphatidase, aminoacidase, peppery
Any one or more of enzymes such as root peroxidase, beta-hydroxybutyric dehydrogenase.The modified biological chemistry on multi-panel working electrode
Reagent, ingredient reacts in the biological chemical reagent and sample to be tested of modification, is analyzed after generating electric current, can obtain to
The ingredient of test sample sheet is more convenient accurate;When the biological chemical reagent of modification is glucose oxidase, Portugal in sample can detect
The concentration of grape sugar;The concentration that can detect lactic acid in sample when the biological chemical reagent of modification is lactate oxidase, when modification
When biological chemical reagent is urate oxidase, the concentration of uric acid in sample can detect.
When modified biological chemical reagent composition is identical on two working electrode of front and back sides, biological chemical reagent ingredient is grape
When carbohydrate oxidase, working principle are as follows:
(1) the detection drop detection sample of sample one is taken to pass through the biological chemical reagent modified on the sucking of capillary diversion channel and electrode
Ingredient reacts.
It (2) is I by the front-side current that electrochemical workstation detects1。
It (3) is I by the reverse side electric current that electrochemical workstation detects2。
(4) electric current is made the difference and enables I=| I1-I2|, wherein current difference I represents the correctness of testing result, and value is smaller,
Testing result accuracy is higher.The concentration for calculating glucose in detection sample can be corresponded to.
When modified biological chemical reagent composition is not identical on two working electrode of front and back sides, biological chemical reagent ingredient difference
When for glucose oxidase with urate oxidase, working principle are as follows:
(1) the detection drop detection sample of sample one is taken to pass through the biological chemical reagent modified on the sucking of capillary diversion channel and electrode
Ingredient reacts.
It (2) is I by the front-side current that electrochemical workstation detects1。
It (3) is I by the reverse side electric current that electrochemical workstation detects2。
Pass through I1With I2Value can directly calculate separately out detection sample in the concentration of glucose and the concentration of uric acid.
Embodiment 2
The present embodiment the difference from embodiment 1 is that: be respectively provided with an electrode group in two opposite sides of substrate 1.?
The two sides of substrate 1 are respectively provided with an electrode group, and the detection of multiple samples or same sample multiple parameters may be implemented.Substrate
1 two opposite sides refer to the left side and right side of substrate 1.
As a specific embodiment, the electrode group of two opposite sides of substrate 1 is located in detection slot 11 and has
The exposed face contacted with substance to be detected.Detection slot 11 is set in two sides, the detection slot 11 of groove structure can prevent to be measured
Sample outflow, referring to Fig. 3.Specifically, 11 one end of detection slot is equipped with the adding mouth for adding sample to be tested.
As a specific embodiment, two sides of substrate 1 are equipped with recognition terminal 24, and recognition terminal 24 is located at work
Make between electrode 21 and auxiliary electrode 22.One and only one recognition terminal 24 of the two sides has with one of neighbouring electrode terminal
Electrical connection, to achieve the effect that identification.For example, recognition terminal 24 is only electrically connected with adjacent working electrode 21.
As a specific embodiment, the working electrode 21 of 1 two sides of substrate, auxiliary electrode 22, recognition terminal 24, ginseng
It is more suitable with the working electrode 21 of reverse side, auxiliary electrode 22, recognition terminal 23, the arrangement of reference electrode 23 than putting in order for electrode 23
Sequence is on the contrary, to have the function that left and right connects and can work normally.
As a specific embodiment, two sides of the substrate 1 are equipped with siphon cover board 25.
As one embodiment, the both ends of the surface of substrate 1 and the working electrode 21 on two sides are drawn by respective conducting wire
Out, auxiliary electrode 22 is in parallel, and 22 parallel connection of auxiliary electrode refers to that the auxiliary electrode 22 on 1 both ends of the surface of substrate and two sides can be with
A conducting wire is shared, auxiliary electrode 22 may be constructed measure loop with any one working electrode 21.
As a specific embodiment, substrate 1 uses plastic material, such as PBT plastic, and substrate 1 has certain thickness
Degree, substrate 1 wrap electrode group, meet the placement width of two sides electrode group.
When front and back sides, left and right side working electrode on modified biological chemical reagent composition it is not identical, can correspond to and detect
Four kinds of different parameters of sample to be tested of the same race, or the parameter of different samples to be tested.
Content described in this specification embodiment is only enumerating to the way of realization of inventive concept, protection of the invention
Range should not be construed as being limited to the specific forms stated in the embodiments, and protection scope of the present invention is also and in art technology
Personnel conceive according to the present invention it is conceivable that equivalent technologies mean.
Claims (8)
1. a kind of electrochemical sensor electrodes test piece of multi-parameter detection, which is characterized in that including substrate and electrode group, electrode group
Including at least working electrode and auxiliary electrode, an electrode group is respectively provided in the opposite both ends of the surface of substrate.
2. a kind of electrochemical sensor electrodes test piece of multi-parameter detection as described in claim 1, which is characterized in that substrate two
Side is respectively provided with an electrode group.
3. a kind of electrochemical sensor electrodes test piece of multi-parameter detection as claimed in claim 2, which is characterized in that work electricity
Recognition terminal is equipped between pole and auxiliary electrode.
4. a kind of electrochemical sensor electrodes test piece of multi-parameter detection as claimed in claim 3, which is characterized in that Mei Ge electricity
Pole group also has reference electrode.
5. a kind of electrochemical sensor electrodes test piece of multi-parameter detection as claimed in claim 4, which is characterized in that substrate two
Working electrode, auxiliary electrode, recognition terminal and the reference electrode of end face put in order on the contrary;The work electricity of substrate two sides
Pole, auxiliary electrode, recognition terminal and reference electricity put in order on the contrary.
6. a kind of electrochemical sensor electrodes test piece of multi-parameter detection as described in claim 1, which is characterized in that electrode group
With electrode terminal, conducting part and reacting part, electrode terminal, conducting part and reacting part are sequentially connected.
7. a kind of electrochemical sensor electrodes test piece of multi-parameter detection as claimed in claim 6, which is characterized in that substrate two
Side is respectively provided with detection slot, and reactive site is in detection slot and exposing to detection slot.
8. a kind of electrochemical sensor electrodes test piece of multi-parameter detection as claimed in claim 2, which is characterized in that substrate
Both ends of the surface and two sides are equipped with siphon cover board.
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US12017217B2 (en) | 2019-03-01 | 2024-06-25 | Lansion Biotechnology Co., Ltd. | Multi-channel microfluidic chip having five-layer structure |
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