CN107121478A - A kind of biology sensor that can detect that sample is not enough, method - Google Patents
A kind of biology sensor that can detect that sample is not enough, method Download PDFInfo
- Publication number
- CN107121478A CN107121478A CN201710299625.6A CN201710299625A CN107121478A CN 107121478 A CN107121478 A CN 107121478A CN 201710299625 A CN201710299625 A CN 201710299625A CN 107121478 A CN107121478 A CN 107121478A
- Authority
- CN
- China
- Prior art keywords
- electrode
- sample
- biology sensor
- working electrode
- enough
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/403—Cells and electrode assemblies
Abstract
The present invention relates to biological detection instrument field, it is specifically related to a kind of to detect that its composition of the biology sensor of sample deficiency includes insulated substrate, electrode system, detection reagent, middle interlayer, coating, described coating, middle interlayer and insulated substrate is built into reative cell, described middle interlayer is in reaction chamber region hollow out, wherein, described electrode system is included to electrode 1, working electrode and to electrode 2, and described to electrode 1, working electrode and to electrode 2, distal end is arranged in order from injection port to reative cell.The present invention can effectively recognize the test of sample deficiency influence result by the configuration to detecting electrode and the research of testing process and decision logic.
Description
Technical field
The present invention relates to biological detection instrument field, and in particular to a kind of biology sensor that can detect that sample is not enough and profit
Detected with the biology sensor and the not enough method of judgement sample.
Background technology
Biology sensor (biosensor), be it is a kind of using bioactive substance Selective recognition target substance and by its
Concentration or content are converted to the instrument that electric signal is detected, are to make recognition component by the biological sensitive materials of immobilization（Including
The bioactive substances such as enzyme, antibody, antigen, microorganism, cell, tissue, nucleic acid）, appropriate physics and chemistry transducer（Such as oxygen electrode,
Photosensitive tube, FET, piezo-electric crystal etc.）And the analysis tool or system that signal amplifying apparatus is constituted.
Electrochemica biological sensor has been widely used in in-vitro diagnosis field, and these instrument systems can be detected in body fluid
Physiologically substance, facilitate doctor to analyze and diagnose patient status, also there are some instrument systems to be applied to family and use, convenient disease
The self-monitoring of people, these physical signs include blood glucose, cholesterol, uric acid, triglyceride, lactic acid, ketoboidies, enzyme etc..Mesh
Preceding biology sensor has been widely used in clinical detection, wherein most popular example is portable blood sugar test system.
For biology sensor, especially for the biology sensor of domestic type, such as blood glucose meter, due to terminal user's culture
Degree, understandability, skilled operation degree are different, and the process of sample-adding there may be various problems, and these problems are very likely
The testing result of instrument is had a strong impact on, is caused therefore the medication produced and Operative risk.Sample deficiency is wherein very common
One problem, sample deficiency can cause the deviation of testing result to become big, cause medication and Operative risk.According to Andreas Pf ü
The assessment result in the market Portable blood sugar monitoring system in 2013 such as tzner, when being loaded not enough, significant portion of monitoring
System can occur the information of the result of mistake rather than sample deficiency to a certain degree, illustrate that current technology is still present to a certain degree
Defect.
If the day for announcing is that December 10, Patent No. US05582697A1 American invention in 1996 disclose a kind of detection
The not enough biology sensor of sample introduction, its core content is at least to include working electrode, the to electrode and detection sample deficiency the 3rd
Electrode, the 3rd electrode, farther away from injection port, can guarantee that than working electrode and to electrode after such 3rd electrode detection to signal
Sample introduction is enough.The program can not avoid the not enough offset issue of sample completely, and sample sample introduction liquid level front end is likely to occur concave or convex
The situation of liquid level, causes the state that there is part covering working electrode and the 3rd electrode, so can still exist to the knot that makes mistake
The risk of fruit.
And for example the day for announcing be on May 11st, 2004, Patent No. US6733655B1 it is disclosed in U.S. Patent it is another really
Recognize the whether enough biology sensors of sample introduction, its core content is included to electrode, the first working electrode, the second working electrode,
To electrode share, from injection port to it is inner be successively to electrode, the first working electrode, the second working electrode, during test simultaneously test
The signal of first working electrode, the second working electrode, compares the difference of two signals, confirms whether difference exceedes what experiment was set up
Threshold value, such as not above illustrating that sample-adding is enough；If the second working electrode is not filled it up with, two signal differences can be than being larger than threshold
Value, error message can be given, it is ensured that result it is accurate.The program needs to detect the signal of two-way working electrode simultaneously, increases instrument
Cost.
The content of the invention
To overcome the defect that above-mentioned prior art is present, pass through the configuration to detecting electrode and testing process and judgement
The research of logic, the purpose of the present invention aims to provide a kind of high-performance that can be recognized sample deficiency, ensure test result accuracy
Biology sensor.
To realize the purpose of the present invention, inventor provides following technical scheme：
Present invention firstly provides a kind of biology sensor that can detect that sample is not enough（For detecting containing for predetermined substance in sample
Amount）, it, which is constituted, includes insulated substrate, builds the electrode system on insulated substrate, and described electrode system at least includes to electricity
Pole and working electrode, at least cover working electrode and are fixed on the detection reagent on electrode system, build above electrode system
Middle interlayer, build coating above middle interlayer, described coating, middle interlayer and insulated substrate is built into reative cell
（That is sample intake passage）, described middle interlayer is in reaction chamber region hollow out（Will pass through siphonage auto injection）, wherein, it is described
Electrode system include to electrode 1, working electrode and to electrode 2, it is and described to electrode 1, working electrode and to electrode 2 from entering
Sample mouthful is arranged in order to reative cell distal end（I.e. to electrode 1 near injection port, working electrode is placed in the middle, to electrode 2 from injection port most
Far）.
Preferably, in the biology sensor of the present invention, it is described for different Testing index and detectable concentration scope
The width ratio scope of working electrode relative to electrode 1 is 0.1 ~ 1.5；The described width ratio to electrode 2 with respect to working electrode
Example scope is 0.2 ~ 1.5.
As it is further preferred that the present invention biology sensor in, it is described to electrode 1 with respect to working electrode width ratio model
Enclose for 0.4 ~ 0.6.
As it is further preferred that the present invention biology sensor in, it is described to electrode 2 with respect to working electrode width ratio model
Enclose for 0.4 ~ 1.0.
Preferably, in the biology sensor of the present invention, described reative cell there should be air-vent, make to form siphon
With air-vent is arranged at sample intake passage from injection port remote location, and the air-vent of such as embodiment of the present invention passes through coating sample introduction
The punching of passage end edge region is realized.
Preferably, in the biology sensor of the present invention, the material of described insulated substrate include but is not limited to PET, PP,
One kind in PVC, acrylic.
Preferably, in the biology sensor of the present invention, the material of described electrode include but is not limited to graphite, silver, gold,
One kind in platinum, palladium, ITO, IZO, can combine the techniques such as Laser Processing by silk-screen printing, vacuum splashing and plating and build in insulation base
On plate.
Detection reagent is to detect the reaction reagent of target substance, preferably, in the biology sensor of the present invention, it is described
Detection reagent include but is not limited to glucose response reagent, lentochol reaction reagent, uric acid reaction reagent, ketoboidies reaction reagent,
Lactic acid reaction reagent, hemoglobin reaction reagent etc..Reaction reagent can be by the way that specking, silk-screen printing, crack are extruded, ink-jet is beaten
The techniques such as print are fixed on electrode system.
Preferably, in the biology sensor of the present invention, the thickness of described middle interlayer is 0.025mm ~ 0.5mm, more excellent
Choosing, the thickness of middle interlayer is 0.075mm ~ 0.125mm.The material of middle interlayer can be with base material or without the glue of base material
Band, is bonded up after processing；It can also be glue or polymer paste, be got on by silk-screen printing；It is exhausted without other on such as electrode
Edge material is separated, and the material of middle interlayer must be good insulating materials.
Preferably, in the biology sensor of the present invention, PET material, the parent of preferably clear can be used in described coating
Water-treated material, it is transparent that user can be helped easily to confirm reaction zone sample introduction state, it is hydrophilic sample introduction to be made more smoothly, it is non-anti-
Answer chamber region can be with opaque, printing sample introduction mark and Logo, 9971 hydrophilic films of available material such as 3M companies.
Present invention also offers a kind of using above-mentioned biology sensor detection and the not enough method of judgement sample, at least wrap
Include following steps：
（1）When biology sensor, which adds sample, to be detected, the working electrode being also turned on to electrode 1 and to electrode 2 is tested
Current signal I1；
（2）Disconnected at once after the completion of test to electrode 1, test job electrode pair has detected that I1 is cut to the current signal I2 of electrode 2
The time interval for changing to detection I2 is not more than 1 second,
（3）Whether the deviation ratio for contrasting I2 and I1 exceedes preset value, such as in values, then the sufficient result of sample is effective,
I1 is used for calculating providing result, such as exceeds values, then provides the not enough error information of sample.
Note：Result of calculation can use I1 terminal electric current, it would however also be possible to employ the electric current of I1 terminal prior times.
The present invention detects and the not enough method of judgement sample that its principle is：
When blood volume is sufficient, sample fully covers three electrodes.The working electrode currents being also turned on to electrode 1 and to electrode 2
Signal I1, and working electrode are mainly determined to the current signal I2 to electrode 2 by the reaction rate of working electrode, therefore I2
Deviation with I1 will not be very big.
When sample is not enough, particularly sample sample introduction front end face is convex or during concavity, sample may covering part work
Electrode and during to electrode 2, in this case the sample covering to electrode 2 can be less.When detection simultaneously connects to electrode 1 and to electrode 2
During logical working electrode currents signal I1, because fully having been covered to the sample of electrode 1, current signal is mainly by working electrode
Reaction is determined；And disconnect to electrode 1, when detection working electrode is to the current signal I2 of electrode 2, because in this case to electrode
2 sample is covered can be seldom, and detection causes I2 to reduce to forming loop difficulty on electrode 2.Therefore by judging I2 and I1
Deviation, it is easy to recognize sample deficiency influence result test.
Preferably, the present invention is using in above-mentioned biology sensor detection and the not enough method of judgement sample, it is described
Detect that I1 was switched to detection I2 time interval in 0.2 second.
Preferably, the present invention is using in above-mentioned biology sensor detection and the not enough method of judgement sample, it is described
The preset value that I2 and I1 deviation ratio judges, is predefined by specific products experiment test.
Preferably, the present invention is using in above-mentioned biology sensor detection and the not enough method of judgement sample, it is described
There is the incubation that electrode disconnects before testing the working electrode currents signal I1 being also turned on to electrode 1 and to electrode 2, the step
Journey.It can also be 0 to be incubated process time, i.e., be not incubated.
Compared with prior art, the present invention has advantages below：
The present invention can effectively recognize the test of sample deficiency influence result.With the work electricity being also turned on to electrode 1 and to electrode 2
Electrode current signal I carries out result calculating, it is ensured that covers sufficient to electrode area and sample, it is ensured that result is accurate, is surveyed while saving
Sample size is tried, to the test energy trace blood that need to be taken a blood sample, patient's pain is reduced；Different detectable concentrations or detection sample, work electricity
The reaction rate of pole is different, therefore to forming the also different to the requirement of the sample area coverage of electrode 2 of loop, the present invention passes through
I2 and I1 judgement, influences little test flexibly to recognize result, it is to avoid as judgement is fixed in extra increase electrode
The waste of scheme.
Brief description of the drawings
During Figure 1A and 1B are the structural integrity schematic diagram and structural decomposition diagram of biology sensor of the present invention, figure：
800 be complete test piece, and 801 be injection port, and 802 be connection haptic element；100 be insulated substrate, and 200 be electrode system, 300
It is detection reagent, 400 be middle interlayer, and 500 be reative cell, and 600 be coating, and 700 be air-vent.
During Fig. 2 is the structural representation of the electrode system of biology sensor of the present invention, figure：201 be work to electrode 1,202
Make electrode, 203 be to electrode 2.
Fig. 3 is the schematic flow sheet of test sample of the present invention and sample shortage detecting method.
Fig. 4 is sample deficiency detection test case I1 and I2 curve map（40 mg/dL）.
Fig. 5 is sample deficiency detection test case I1 and I2 curve map（120 mg/dL）.
Fig. 6 is sample deficiency detection test case I1 and I2 curve map（350 mg/dL）.
Embodiment
With reference to embodiment, present disclosure is further illustrated.It should be appreciated that the implementation of the present invention is not limited to
In the following examples, any formal accommodation and/or change made to the present invention fall within the scope of the present invention.
In the present invention, if not refering in particular to, all equipment and raw material etc. are commercially available or the industry is conventional.
Method in following embodiments, is the conventional method of this area unless otherwise instructed.
Biosensor testing plate in the embodiment of the present invention is constituted（As shown in Figure 1A, Figure 1B and Fig. 2）, including：
Insulated substrate 100, one kind that material includes but is not limited in PET, PP, PVC, acrylic.
Build the electrode system 200 on insulated substrate.Electrode system at least includes sample introduction to electrode 1-201, work electricity
Pole 202 and to electrode 2-203, to electrode 1, working electrode, to electrode 2, from injection port 801 to sample intake passage, distal end is arranged in order,
I.e. to electrode 1 near injection port 801, working electrode is placed in the middle, farthest from injection port to electrode 2.
For different Testing index and detectable concentration scope, the width ratio scope to electrode 1 with respect to working electrode is
0.1 ~ 1.5, preferably 0.4 ~ 0.6；The width ratio scope of working electrode relative to electrode 2 is 0.2 ~ 1.5, preferably 0.4 ~ 1.0.With
Test in blood sample exemplified by the biology sensor product of glucose content, one embodiment is to electrode 1, working electrode, to electrode 2
Width ratio be 0.4：1：0.6.
One kind that the material of electrode includes but is not limited in graphite, silver, gold, platinum, palladium, ITO, IZO, can pass through screen printing
Brush, vacuum splashing and plating combine the techniques such as Laser Processing and built on insulated substrate.
At least cover working electrode 202 and the detection reagent 300 being fixed on electrode system.Detection reagent is detection target
The reaction reagent of material, including but not limited to glucose response reagent, lentochol reaction reagent, uric acid reaction reagent, ketoboidies are anti-
Answer reagent, lactic acid reaction reagent, hemoglobin reaction reagent etc..Reaction reagent can be squeezed by specking, silk-screen printing, crack
Go out, the technique such as inkjet printing is fixed on electrode system.
The middle interlayer 400 above electrode system is built, the thickness of described middle interlayer is 0.025mm ~ 0.5mm, as
It is preferred that, the thickness of middle interlayer is 0.075mm ~ 0.125mm.Middle interlayer material can be with base material or without the adhesive tape of base material, plus
Bonding is got on after work is good；It can also be glue or polymer paste, be got on by silk-screen printing；Without other insulating materials on such as electrode
Separate, the material of middle interlayer must be good insulating materials.
The coating 600 above middle interlayer is built, coating, middle interlayer and insulated substrate are built into reative cell 500（I.e.
Sample intake passage）, will pass through siphonage auto injection.Coating can be used PET material, what the hydrophilic treated of preferably clear was crossed
Material, transparent that user can be helped easily to confirm reaction zone sample introduction state, hydrophilic sample introduction to be made more smoothly, non-reaction chamber region can
With opaque, printing sample introduction mark and Logo, 9971 hydrophilic films of available material such as 3M companies.
Reative cell has air-vent 700, and to form siphonage, the air-vent of such as embodiment of the present invention is entered by coating
The punching of sample passage end edge region is realized.
Embodiment 1
As shown in Figure 1A, Figure 1B and Fig. 2, a kind of biology sensor that can detect that sample is not enough, its composition includes insulated substrate, structure
The electrode system building on insulated substrate, described electrode system is at least included to electrode 1, working electrode and to electrode 2, at least
Cover working electrode and be fixed on the detection reagent on electrode system, build the middle interlayer above electrode system, build in
Coating above interlayer, described coating, middle interlayer and insulated substrate is built into reative cell（That is sample intake passage）, it is described
Chamber region hollow out is reacted, wherein, it is described that to electrode 1, working electrode and to electrode 2, distal end is arranged successively from injection port to reative cell
Row.It is described to electrode 1, working electrode, to electrode 2 by taking the biology sensor product for testing glucose content in blood sample as an example
Width ratio be 0.4：1：0.6.
As shown in figure 3, test sample of the present invention and the detection of sample deficiency and the method judged, comprise the following steps：
（1）Insert biosensor testing plate and connect haptic element end to instrument, instrument startup self-detection.
（2）After the completion of self-inspection, instrument is by connecting haptic element to adding DC between electrode 1 and working electrode（Direct current）Or AC（Hand over
Stream）Voltage, detection sample introduction signal F1.Preferably, AC (exchange) voltage detecting impedance signal is preferred.Because when temperature compared with
Low, sample object material concentration it is very low or for 0 when, DC（Direct current）Under voltage, current signal is very low, and background noise difference is very
It is small, easily erroneous judgement；By AC (exchange) voltage detecting impedance signal, even in temperature is relatively low, sample object material concentration is very low
Or when being 0, when reagent covering may be no or seldom between detecting electrode, the impedance signal detected can also make an uproar with background well
Sound is distinguished, it is to avoid erroneous judgement.
（3）Judge whether threshold value is exceeded to the sample introduction signal F1 between electrode 1 and working electrode, threshold value passes through in varying environment
The different sample of lower test, which is summarized, to be determined.If not above threshold value, continuing to detect sample introduction signal F1；If more than threshold value, under
One step.
（4）In working electrode and to adding DC between electrode 2（Direct current）Voltage or amplitude less AC (exchange) voltage, and detect
Signal F2.
（5）Judge working electrode and to the detection signal F2 between electrode 2 whether exceed threshold value, such as not above threshold value, then after
Continuous detection F2；Such as exceed threshold value, then into next step.
（6）Close working electrode and to interelectrode potential difference, be incubated；Incubation time is set according to different product requirement
Put, incubation time can be 0.
（7）It is grounded simultaneously to electrode 1 and to electrode 2, and adds operating voltage, sensed current signal on the working electrode (s
I1；
（8）（7）After the completion of step, disconnect at once to electrode 1, detection working electrode and the current signal I2 to electrode 2, detection
The time interval that complete I1 is switched to detection I2 is not more than 1 second, preferably in 0.2 second；
（9）Compare I2 and I1 deviation（Rate）, deviation（Rate）More than threshold value, the not enough error warning of sample is provided；
（10）Compare I2 and I1 deviation（Rate）, deviation（Rate）In threshold range, then the sufficient result of sample effectively, is calculated with I1
As a result.
Use above-mentioned biosensor testing plate, the reaction reagent of glucose detection, and the not enough testing process of sample
And decision logic：
The（2）Step and the（4）Step is using AC detections；The（3）Step and the（5）The threshold value of step is set to 100；The（6）When step is incubated
Between be 0；The（7）Step is to electrode 1（C1）With to electrode 2（C2）The working electrode being also turned on（W）Current signal detection 5 seconds, I1
Take 5 seconds results；The（8）Step is the（7）Detected at once after the completion of step, interval is not more than 0.1 second, one value of collection is I2；
The（9）I2 the and I1 deviation ratios of step relatively use deviation ratio, and threshold value is set to 20%.
The contrastive test that sample is not enough and sample is sufficient is carried out, three concentration are tested altogether：40mg/dL, 120mg/dL and
Tri- concentration of glucose of 350mg/dL.Instrument record simultaneously exports whole test datas.I2 and I1 results and comparison are analyzed as follows and stated
Shown in form and Fig. 4, Fig. 5, Fig. 6.
From the result of embodiment, when sample-adding is sufficient, I2 and I1 deviation very little, all within 10%；When being loaded not enough,
I2 and I1 deviation is very big, most of to be more than 20%.20% judgement is set to threshold value, test I1 results that sample-adding is not enough and sample-adding fill
Test of the I1 mean bias of foot test beyond 10% can be excluded all, it is ensured that result is accurate.
I1 and I2 test datas curve map such as Fig. 4（40 mg/dL）, Fig. 5（120 mg/dL）, Fig. 6（350 mg/dL）Institute
Show, curve map can also be clearly apparent, the not enough test I2 of sample（5.1 the second）Compared with I1（5 seconds）It is decreased obviously.
As can be seen here, technical scheme can effectively recognize that sample is not enough, influence the test of test result, it is ensured that knot
The accuracy of fruit.
Claims (8)
1. a kind of biology sensor that can detect that sample is not enough, its composition includes insulated substrate；Build the electricity on insulated substrate
Electrode systems, described electrode system at least includes working electrode and to electrode；At least cover working electrode and be fixed on electrode system
Detection reagent on system；The middle interlayer above electrode system is built, described middle interlayer is in reaction chamber region hollow out；Build
Coating above middle interlayer, described coating, middle interlayer and insulated substrate is built into reative cell, and described reative cell is provided with
Air-vent；Characterized in that, described electrode system is included to electrode 1, working electrode and to electrode 2, and to electrode 1, work
Electrode and to electrode 2 from injection port to reative cell distal end be arranged in order.
2. a kind of biology sensor that can detect that sample is not enough according to claim 1, it is characterised in that described to electricity
Pole 1 is 0.1 ~ 1.5 with respect to the width ratio scope of working electrode, the width ratio model to electrode 2 with respect to working electrode
Enclose for 0.2 ~ 1.5.
3. a kind of biology sensor that can detect that sample is not enough according to claim 2, it is characterised in that described to electricity
Pole 1 is 0.4 ~ 0.6 with respect to the width ratio scope of working electrode.
4. a kind of biology sensor that can detect that sample is not enough according to claim 2, it is characterised in that described to electricity
Pole 2 is 0.4 ~ 1.0 with respect to the width ratio scope of working electrode.
5. a kind of biology sensor that can detect that sample is not enough according to claim 1, it is characterised in that described reaction
Room should have air-vent, and air-vent is arranged at sample intake passage from injection port remote location.
6. biology sensor detection and the not enough method of judgement sample described in a kind of one of utilization claim 1-5, its feature
It is at least to comprise the following steps：
（1）When biology sensor, which adds sample, to be detected, the working electrode being also turned on to electrode 1 and to electrode 2 is tested
Current signal I1；
（2）Disconnected at once after the completion of test to electrode 1, test job electrode pair has detected that I1 is cut to the current signal I2 of electrode 2
The time interval for changing to detection I2 is not more than 1 second,
（3）Whether the deviation ratio for contrasting I2 and I1 exceedes preset value, such as in values, then the test of sample abundance is effective,
Such as exceed values, then provide the not enough error information of sample.
7. a kind of method detected with judgement sample deficiency according to claim 6, it is characterised in that described detection is complete
I1 was switched to detection I2 time interval in 0.2 second.
8. a kind of method detected with judgement sample deficiency according to claim 6, it is characterised in that described test pair
There is the incubation process that electrode disconnects before electrode 1 and the working electrode currents signal I1 being also turned on to electrode 2, the step.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710299625.6A CN107121478A (en) | 2017-05-01 | 2017-05-01 | A kind of biology sensor that can detect that sample is not enough, method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710299625.6A CN107121478A (en) | 2017-05-01 | 2017-05-01 | A kind of biology sensor that can detect that sample is not enough, method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107121478A true CN107121478A (en) | 2017-09-01 |
Family
ID=59726115
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710299625.6A Pending CN107121478A (en) | 2017-05-01 | 2017-05-01 | A kind of biology sensor that can detect that sample is not enough, method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107121478A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108132284A (en) * | 2017-12-26 | 2018-06-08 | 三诺生物传感股份有限公司 | A kind of test method of electrochemical sensor |
| CN109358101A (en) * | 2018-08-31 | 2019-02-19 | 浙江大学山东工业技术研究院 | A kind of electrochemical sensor electrodes test piece of multi-parameter detection |
| WO2022100617A1 (en) * | 2020-11-11 | 2022-05-19 | 利多(香港)有限公司 | Biosensor |
| CN114778631A (en) * | 2022-06-17 | 2022-07-22 | 北京华益精点生物技术有限公司 | Body index detection device and method |
| CN114935599A (en) * | 2022-04-08 | 2022-08-23 | 无锡博慧斯生物医药科技有限公司 | Method for judging whether sample adding quantity is sufficient or not and method for detecting analyte concentration in sample |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101900701A (en) * | 2009-05-25 | 2010-12-01 | 利多(香港)有限公司 | Biosensor |
| CN106124595A (en) * | 2016-06-17 | 2016-11-16 | 浙江亿联健医疗器械有限公司 | A kind of biosensor and preparation method thereof and reaction reagent |
| CN106226379A (en) * | 2016-07-10 | 2016-12-14 | 浙江亿联健医疗器械有限公司 | A kind of biosensor eliminating sample introduction process influence and method of testing |
-
2017
- 2017-05-01 CN CN201710299625.6A patent/CN107121478A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101900701A (en) * | 2009-05-25 | 2010-12-01 | 利多(香港)有限公司 | Biosensor |
| CN103487476A (en) * | 2009-05-25 | 2014-01-01 | 利多(香港)有限公司 | Biosensor |
| CN106124595A (en) * | 2016-06-17 | 2016-11-16 | 浙江亿联健医疗器械有限公司 | A kind of biosensor and preparation method thereof and reaction reagent |
| CN106226379A (en) * | 2016-07-10 | 2016-12-14 | 浙江亿联健医疗器械有限公司 | A kind of biosensor eliminating sample introduction process influence and method of testing |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108132284A (en) * | 2017-12-26 | 2018-06-08 | 三诺生物传感股份有限公司 | A kind of test method of electrochemical sensor |
| CN108132284B (en) * | 2017-12-26 | 2019-11-29 | 三诺生物传感股份有限公司 | A kind of test method of electrochemical sensor |
| CN109358101A (en) * | 2018-08-31 | 2019-02-19 | 浙江大学山东工业技术研究院 | A kind of electrochemical sensor electrodes test piece of multi-parameter detection |
| WO2022100617A1 (en) * | 2020-11-11 | 2022-05-19 | 利多(香港)有限公司 | Biosensor |
| CN114935599A (en) * | 2022-04-08 | 2022-08-23 | 无锡博慧斯生物医药科技有限公司 | Method for judging whether sample adding quantity is sufficient or not and method for detecting analyte concentration in sample |
| CN114935599B (en) * | 2022-04-08 | 2023-11-14 | 无锡博慧斯生物医药科技有限公司 | Method for determining whether an amount of sample added is sufficient and method for detecting an analyte concentration in a sample |
| CN114778631A (en) * | 2022-06-17 | 2022-07-22 | 北京华益精点生物技术有限公司 | Body index detection device and method |
| CN114778631B (en) * | 2022-06-17 | 2022-12-02 | 北京华益精点生物技术有限公司 | Body index detection device and method |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107121478A (en) | A kind of biology sensor that can detect that sample is not enough, method | |
| US8038859B2 (en) | Electrochemical sensor and method for analyzing liquid sample | |
| US7138041B2 (en) | Electrochemical biosensor by screen printing and method of fabricating same | |
| CN1456886A (en) | Manufacturing method for physiological sample collector | |
| US20070205114A1 (en) | Method of detecting biosensor filling | |
| WO2008088357A1 (en) | Ultrasensitive amperometric saliva glucose sensor strip | |
| CN106226379A (en) | A kind of biosensor eliminating sample introduction process influence and method of testing | |
| JP4399581B2 (en) | Biosensor | |
| CN107328830B (en) | A kind of biosensor | |
| WO2022100617A1 (en) | Biosensor | |
| CN209086198U (en) | A kind of blood glucose, the difunctional electrochemical test strip of uric acid | |
| TWM467058U (en) | Biochemical sensor | |
| CN1851459A (en) | Multi-parameter whole blood integrating test bar | |
| CN101308134B (en) | Whole blood lactic acid/ blood sugar test strip and integral blood taking needle | |
| KR102042749B1 (en) | Sensor strip and Apparatus for measuring biomaterial using the sensor strip | |
| CN203535003U (en) | Biosensor | |
| CN203249891U (en) | Biosensor | |
| JP2007155622A (en) | Biosensor chip with needle and biosensor system | |
| RU2681666C2 (en) | End-filling electrochemical analytical test-strip with perpendicular intersecting sample-receiving chambers | |
| CN103091377B (en) | Biosensor | |
| CN108132284B (en) | A kind of test method of electrochemical sensor | |
| CN204594918U (en) | Anti-interference sensing electrode | |
| CN107290417A (en) | A kind of biology sensor for improving reagent crystal habit | |
| US10928352B2 (en) | Analyte detection in a contaminated sample | |
| CN208537470U (en) | Binary channel glucose oxidase film electrode |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information |
Address after: 317317 industrial cluster area of Baita Town Xianju County Taizhou city Zhejiang Province Applicant after: Zhejiang Yi Lian Kang Medical Technology Co., Ltd. Address before: 317317 industrial cluster area of Baita Town Xianju County Taizhou city Zhejiang Province Applicant before: Taizhou Yi Jian Jian Medical Technology Co., Ltd. |
|
| CB02 | Change of applicant information | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170901 |
|
| RJ01 | Rejection of invention patent application after publication |