CN109351372A - 一种可拦截杂质的滤膜可调式单向微流控芯片 - Google Patents

一种可拦截杂质的滤膜可调式单向微流控芯片 Download PDF

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CN109351372A
CN109351372A CN201811430820.9A CN201811430820A CN109351372A CN 109351372 A CN109351372 A CN 109351372A CN 201811430820 A CN201811430820 A CN 201811430820A CN 109351372 A CN109351372 A CN 109351372A
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micro
filter membrane
fluidic chip
chamber
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袁刘杰
王继业
姚伟宣
吕云平
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Zhejiang Police College
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    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
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    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
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    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
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    • B01L2400/06—Valves, specific forms thereof
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Abstract

本发明公开一种可拦截杂质的滤膜可调式单向微流控芯片。所述微流控芯片由基片和滤膜插入组合构成,该微流控芯片包括样品入口和样品出口，样品入口和样品出口有流道连通。样品入口包括样品收集室、样品收集室入口、样品收集室出口、长方形柱状体和滤膜；样品收集室为圆柱形腔室,样品收集室入口位于圆柱形腔室顶部,样品收集室出口位于圆柱形腔室侧壁上，长方形柱状体位于圆柱形腔室内腔壁两侧；滤膜插入于样品收集室中。样品出口无长方形柱状体，其它结构与样品入口一致。本发明的微流控芯片样品进出口结构简单,样品进口可拦截样品中的杂质并让其余物质通过,提高了检测精度以及检测效率。

Description

一种可拦截杂质的滤膜可调式单向微流控芯片
技术领域
本发明属于微流控芯片,具体涉及一种带有样品入口和样品出口的微流控芯片。
背景技术
市场上的微流控芯片包括样品入口、样品检测单元和样品出口,这种微流控芯片的样品入口不能拦截待检样品中的杂质,由于待检样品中会含有杂质,需设置专门的拦截单元来拦截待检样品中的杂质,因而这种微流控芯片结构复杂。
发明内容
本发明的目的是提供一种结构简单且样品入口可拦截待检样品中杂质的微流控芯片。
为了实现上述目的,本发明的技术方案是:
一种微流控芯片,由基片和滤膜插入组合构成,基片内开有两端开放的“凵”形腔室，该腔室包括样品入口、样品出口,样品入口与样品出口有流道连通；流道内设有样品检测单元；
所述样品入口位于基片“凵”形腔室的其中一臂，具体包括样品收集室、两个长方形柱状体和滤膜；样品收集室为圆柱形腔室，样品收集室入口位于圆柱形腔室的顶部，样本收集室出口位于圆柱形腔室侧壁上；两个长方形柱状体分别位于圆柱形腔室内腔壁两侧，用于放置滤膜；滤膜设置在样品收集室的顶部，并置于长方形柱状体上方；滤膜为可拆卸设置；
上述微流控芯片的样品收集室的尺寸为:1600μm≤圆柱形腔室直径≤3200μm,40μm≤圆柱形腔室高度≤60μm。
上述微流控芯片的样品收集室出口的宽度为:592～608μm，高度为20～40μm；
上述微流控芯片的样品收集室插入的滤膜的尺寸为：1600μm≤圆筒形直径≤3200μm,30μm≤圆筒形高度≤40μm，孔径分为20μm、40μm和60μm三类。
上述微流控芯片的样品出口位于基片“凵”形腔室的另一臂，具体包括样品出口室、样品出口室入口和样本出口室出口；样品出口室为圆柱形腔室，样本出品室入口位于圆柱形腔室下端侧壁上，样品出口室出口位于圆柱形腔室顶部。
上述微流控芯片的样品出口的样品出口室的尺寸为：1600μm≤圆柱形腔室直径≤3200μm,40μm≤圆柱形腔室高度≤60μm。
上述微流控芯片的样品出口的样本出口室入口的宽度为592～608μm，高度为20～40μm。
所述样品检测单元为现有成熟检测模块。
本发明的好处是：由于样品入口的样品收集室内腔壁两侧设有两个长方形柱状体，可根据待检样品的种类选择不同孔径的滤膜，可拦截待检样品中的杂质并让其余物质通过，结构简单且能够提高检测精度及检测效率。
附图说明
图1是本发明的微流控芯片一种实施例的结构示意图；
图2是本发明的微流控芯片的立体示意图；
图3是本发明的微流控芯片的俯视图；
图4是本发明的样品入口的侧视图。
图中标记：样品入口1，样品收集室1－1，样本收集室入口1-2，滤膜1-3，长方形柱状体1-4，样本收集室出品1-5，样品检测单元2，样品出口3，样本出口室3-1，样本出口室入口3-2，样本出口室出口3-3。
具体实施方式
以下结合附图以及给出的实施例，对本发明作进一步说明。
如图1-4所示，一种微流控芯片，由基片和滤膜插入组合构成，包括样品入口1和样品出口3,所述样品入口1与样品出口3相连通；
所述样品入口包括样品收集室1-1、样本收集室入口1-2、样本收集室出品1-5、长方形柱状体1-4和滤膜1-3。样品收集室为圆柱形腔室，样品收集室入口1-2位于圆柱形腔室顶部，样本收集室出口1-5位于圆柱形腔室下端侧壁上，长方形柱状体1-4位于圆柱形腔室内腔壁两侧，用于放置滤膜。
上述样品收集室1-1的尺寸为：1600μm≤圆柱形腔室直径≤3200μm,40μm≤圆柱形腔室高度≤60μm。
上述滤膜1-3的尺寸为：1600μm≤圆筒形直径≤3200μm,30μm≤圆筒形高度≤40μm，孔径分为20μm、40μm和60μm三类。
上述样品收集室出口1-5的宽度为600±8μm，高度为20～40μm。
上述样品出口3包括样本出口室3-1、样本出口室入口3-2和样本出口室出口3-3；样本出口室3-1为圆柱形腔室，样本出口室入口3-2位于圆柱形腔室侧壁上，样本出口室出口3-3位于圆柱形腔室顶部。
上述样本出口室3-1的尺寸为：1600μm≤圆柱形腔室直径≤3200μm,40μm≤圆柱形腔室高度≤60μm。
上述样本出口室入口3-2的宽度为600±8μm，高度为20～40μm。
如图1所示，样品检测单元2与所述样品入口1以及样品出口3依次相连通。
用本发明的微流控芯片的样品入口1进行样品检测时，按图1所示，将本发明的微流控芯片的样品入口1与样品检测单元2以及样品出口3依次相连通后就可以对待测样品进行检测。
如图1所示,当待检测样品从样品收集室入口1-2注入后,由于滤膜1-3的过滤作用,样品中的杂质将会被拦截于滤膜1-3中,其余滤液由样本收集室出口1-4流进检测单元2进行检测后经样品出口3流出。
如此可见,本发明的微流控芯片既可以拦截检测样品中的杂质又不影响检测,同时结构简单、成本低,具有积极的社会效果。
上述实施例并非是对于本发明的限制，本发明并非仅限于上述实施例，只要符合本发明要求，均属于本发明的保护范围。

Claims (6)

1.一种可拦截杂质的滤膜可调式单向微流控芯片，其特征在于包括样品入口、样品出口,样品入口与样品出口有流道连通；流道内设有样品检测单元；
所述样品入口包括样品收集室、两个长方形柱状体和滤膜；样品收集室为圆柱形腔室，样品收集室入口位于圆柱形腔室的顶部，样本收集室出口位于圆柱形腔室侧壁上；两个长方形柱状体分别位于圆柱形腔室内腔壁两侧，用于放置滤膜；滤膜设置在样品收集室的顶部，并置于长方形柱状体上方；
所述样品出口包括样品出口室、样品出口室入口和样本出口室出口；样品出口室为圆柱形腔室，样本出品室入口位于圆柱形腔室下端侧壁上，样品出口室出口位于圆柱形腔室顶部。
2.如权利要求1所述的一种可拦截杂质的滤膜可调式单向微流控芯片，其特征在于上述微流控芯片的样品收集室的尺寸为:1600μm≤圆柱形腔室直径≤3200μm,40μm≤圆柱形腔室高度≤60μm。
3.如权利要求1所述的一种可拦截杂质的滤膜可调式单向微流控芯片，其特征在于上述微流控芯片的样品收集室出口的宽度为:592～608μm，高度为20～40μm。
4.如权利要求1所述的一种可拦截杂质的滤膜可调式单向微流控芯片，其特征在于上述微流控芯片的样品收集室插入的滤膜的尺寸为：1600μm≤圆筒形直径≤3200μm,30μm≤圆筒形高度≤40μm，孔径分为20μm、40μm和60μm三类。
5.如权利要求1所述的一种可拦截杂质的滤膜可调式单向微流控芯片，其特征在于上述微流控芯片的样品出口的样品出口室的尺寸为：1600μm≤圆柱形腔室直径≤3200μm,40μm≤圆柱形腔室高度≤60μm。
6.如权利要求1所述的一种可拦截杂质的滤膜可调式单向微流控芯片，其特征在于上述微流控芯片的样品出口的样本出口室入口的宽度为592～608μm，高度为20～40μm。
CN201811430820.9A 2018-11-28 2018-11-28 一种可拦截杂质的滤膜可调式单向微流控芯片 Withdrawn CN109351372A (zh)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109985679A (zh) * 2019-04-24 2019-07-09 浙江警察学院 一种spr检测仪用多通道微流控芯片夹持系统
CN109985678A (zh) * 2019-04-24 2019-07-09 浙江警察学院 一种适用于手持式spr检测仪的液体样本采集存储装置
CN113846017A (zh) * 2021-10-13 2021-12-28 无锡药明生物技术股份有限公司 选择截留装置和降低截留率的方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106345547A (zh) * 2016-11-08 2017-01-25 常州锐德医疗科技有限公司 一种微流控芯片
CN107523481A (zh) * 2017-08-17 2017-12-29 北京旌准医疗科技有限公司 一种基于微流控芯片的微纳生物粒子分选设备

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106345547A (zh) * 2016-11-08 2017-01-25 常州锐德医疗科技有限公司 一种微流控芯片
CN107523481A (zh) * 2017-08-17 2017-12-29 北京旌准医疗科技有限公司 一种基于微流控芯片的微纳生物粒子分选设备

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109985679A (zh) * 2019-04-24 2019-07-09 浙江警察学院 一种spr检测仪用多通道微流控芯片夹持系统
CN109985678A (zh) * 2019-04-24 2019-07-09 浙江警察学院 一种适用于手持式spr检测仪的液体样本采集存储装置
CN113846017A (zh) * 2021-10-13 2021-12-28 无锡药明生物技术股份有限公司 选择截留装置和降低截留率的方法
CN113846017B (zh) * 2021-10-13 2024-04-26 无锡药明生物技术股份有限公司 选择截留装置和降低截留率的方法

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