CN109350670A - 复方鱼腥草滴丸的制备方法 - Google Patents
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Abstract
本发明公开了一种复方鱼腥草滴丸的制备方法,由鱼腥草、黄芩、板蓝根、连翘、金银花为原料药制成,其方法为:将上述处理提取挥发油,收集备用;上述回味药渣水提,滤过,滤液浓缩至在60℃时测相对密度为1.05~1.30,加乙醇,使含醇量达到55%‑85%,过滤,回收乙醇,制成流浸膏;黄芩水提,滤过,沉淀用乙醇洗、水洗至PH4‑7,低温干燥,粉碎,得黄芩提取物粉;将黄芩提取物粉加入到流浸膏中,加挥发油,混匀,加入到辅料中,混匀,制成滴丸。
Description
技术领域
本发明属中草药领域,尤其涉及到一种治疗外感风热引起咽喉疼痛、急性咽炎、扁桃体炎的复方鱼腥草滴丸的制备方法。
背景技术
咽炎、扁桃体炎是上呼吸道感染常见的症状,中医属喉科之喉蛾、喉痹范畴,是外感风热引起的。西医则认为,咽炎、扁桃体炎是咽喉粘膜及其淋巴组织的炎症,病因主要是细菌、病毒感染、理化因素粉尘、烟酒等刺激,也可继发于全身性疾病或是其他疾病的前期症状,治疗大多采用抗生素类药物辅以含化片剂等方法,但疗效往往不理想,症状虽有减轻,但咽喉的肿痛、干痒等症常迁延难愈、不易根除,有的数月不愈,从而导致了抗生素滥用。
中医运用整体观念和辩证论治对外风热引起的咽喉疼痛、急性咽炎、扁桃体炎常采用清热解毒的办法。本发明的复方鱼腥草滴丸采用了鱼腥草、黄芩、板蓝根、连翘、金银花五味药,通过协同作用达到清咽利喉、毒副作用小、不反复发作的效果。
鱼腥草性辛,微寒,归肺经,具有清热解毒、消痛排脓、利尿通淋的功效,是君药。现代药理研究表明,鱼腥草有抗菌、抗病毒、免疫调节、利尿作用。临床有对其治疗109例24种急慢性炎症的报道,证明其有确切疗效。
黄芩性苦,寒,归肺、胆、脾、大肠、小肠经,具有清热燥湿、泻火解毒、止血、安胎功效,是臣药。药理报导:它有抗微生物的作用,抗炎和抗变态反应作用。低剂量黄芩苷可明显促进刀豆球蛋白A(ConA)诱导的小鼠脾淋巴细胞增殖反应,高剂量则显著抑制,并有降低血压和利尿作用、降血脂作用、抗血板聚集和抗凝作用、抗氧化作用、对中枢神经系统有显著镇静作用。临床报道治疗小儿急性呼吸道感染51例、急慢支气管炎11例、急性扁桃体炎1例,治后体温降至正常,症状消失者51例,无效12例。
板蓝根性苦、寒,归心、胃经,具有清热解毒、凉血利咽的功效。药理报道,板蓝根有抗细菌、抗病毒的作用,抗内毒素作用、抗癌作用,对免疫有调节作用,临床用于治疗小儿病毒性上呼吸道感染,针剂182例,显效60例,有效12例,颗粒剂50例,显效20例,有效16例。
连翘性苦,微寒,归肺、心、小肠经。具有清热解毒、消肿散结之功效。药理研究表明,连翘是一种广谱有效的抗微生物的药物,体外试验对许多种细菌有抑制作用。临床用于清热解毒的急性扁桃体炎、咽炎、慢性支气管炎的中药较多,以传统中药剂为多。目前,市场上有类似的复方鱼腥草片、胶囊,不但生产工艺落后,有效成分含量低,质量标准不完善,而且崩解慢,释药慢,生物利用度低,疗效有待提高。
发明内容
本发明的目的是提供一种复方鱼腥草滴丸的制备方法,该方法制备的复方鱼腥草滴丸是速效制剂,其基质不仅能载药和赋予滴丸形状,而且可以利用固体分散技术和其高分子材料自身特性增加药物的溶解质和溶出度,发挥药效迅速,生物利用度高,是市场上受欢迎的剂型。发明人在改进工艺、分析溶出度、提高质量标准、完成药理药效学比较的基础上完成了本发明。
为了达到上述目的本发明是这样来实现的:,由鱼腥草、黄芩、板蓝根、连翘、金银花为原料药制成,其特征在于其制备方法为:
(1)将鱼腥草、板蓝根、连翘、金银花混合或单独提取挥发油,收集挥发油,备用;
(2)上述回味药渣水提,滤过,滤液浓缩至在60℃时测相对密度为1.05~1.30,加乙醇,使含醇量达到55%-85%,过滤,回收乙醇,制成流浸膏;
(3)黄芩水提,水提液调PH至1.0~3.0,60℃-95℃保温0.5-2.5小时,静置12-48小时,滤过,沉淀用乙醇洗、水洗至PH4-7,低温干燥,粉碎,得黄芩提取物粉;
(4)将黄芩提取物粉加入到流浸膏中,加挥发油,混匀,加入到辅料中,混匀,制成滴丸。
本发明的优点是:具有清热解毒的功效,用于外感风热引起的咽喉疼痛、急性咽炎、扁桃体炎。临床上对上呼吸道感染、急性扁桃体炎、咽炎、牙周炎、慢性支气管炎、肺脓疡、便毒等。
具体实施方式
下面结合实施例对本发明作进一步说明。
实施例1:取 鱼腥草1100g 、黄芩333g 、板蓝根333g 、连翘116g 、金银花116g,鱼腥草、板蓝根、连翘、金银花加12倍量的水浸泡4小时,用水蒸汽蒸馏提取,挥发油另器保存,备用;药渣过滤,滤液[I]另存;药渣加19倍量的水继续煎煮2次,每次1小时,合并煎液,滤过,与滤液[I]合并,浓缩至在60℃时测相对密度1.15左右,放冷,加乙醇使含醇量达到70%,放置24小时,过滤,滤液回收乙醇并继续浓缩成流浸膏,备用;取黄芩,加19倍量的水煎煮二次,每次2小时,滤过,合并滤液,适当浓缩,用盐酸调节PH值2,80℃保温1小时,静置24小时,滤过,沉淀用90%乙醇洗,再用水洗至PH5,减压低温干燥,粉碎,得黄芩提取物粉,加入到上述流浸膏中,加入挥发油,混匀;取PEG-6000熔融,将药物加入到熔融液态基质中,药物与基质配比1∶2-4为宜,优选1∶3。在80℃保温状态下滴制,以二甲基硅油为冷凝剂,冷却温度-4℃,收集滴丸,擦拭,即得。
Claims (1)
1.一种复方鱼腥草滴丸的制备方法,由鱼腥草、黄芩、板蓝根、连翘、金银花为原料药制成,其特征在于其制备方法为:
(1)将鱼腥草、板蓝根、连翘、金银花混合或单独提取挥发油,收集挥发油,备用;
(2)上述回味药渣水提,滤过,滤液浓缩至在60℃时测相对密度为1.05~1.30,加乙醇,使含醇量达到55%-85%,过滤,回收乙醇,制成流浸膏;
(3)黄芩水提,水提液调PH至1.0~3.0,60℃-95℃保温0.5-2.5小时,静置12-48小时,滤过,沉淀用乙醇洗、水洗至PH4-7,低温干燥,粉碎,得黄芩提取物粉;
(4)将黄芩提取物粉加入到流浸膏中,加挥发油,混匀,加入到辅料中,混匀,制成滴丸。
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN111135233A (zh) * | 2020-01-14 | 2020-05-12 | 南京医科大学附属口腔医院 | 一种治疗慢性牙周炎的免疫调节制剂及其制备方法 |
CN113350457A (zh) * | 2021-07-20 | 2021-09-07 | 江苏白马生态环保研究院有限公司 | 一种复合中药抗菌抗病毒剂及其制备方法 |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN111135233A (zh) * | 2020-01-14 | 2020-05-12 | 南京医科大学附属口腔医院 | 一种治疗慢性牙周炎的免疫调节制剂及其制备方法 |
CN113350457A (zh) * | 2021-07-20 | 2021-09-07 | 江苏白马生态环保研究院有限公司 | 一种复合中药抗菌抗病毒剂及其制备方法 |
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