CN109331078A - A kind of preparation method for the herbal medicine compound oral liquid improving pigling immunity - Google Patents

A kind of preparation method for the herbal medicine compound oral liquid improving pigling immunity Download PDF

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CN109331078A
CN109331078A CN201811535508.6A CN201811535508A CN109331078A CN 109331078 A CN109331078 A CN 109331078A CN 201811535508 A CN201811535508 A CN 201811535508A CN 109331078 A CN109331078 A CN 109331078A
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preparation
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herbal medicine
oral liquid
medicine compound
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徐海军
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West Anhui University
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West Anhui University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/756—Phellodendron, e.g. corktree
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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Abstract

The invention discloses a kind of preparation methods of herbal medicine compound oral liquid for improving pigling immunity, comprising the following steps: step 1: the component of Chinese veterinary medicinal composition is extracted；Step 2: water decoction is filtered, be concentrated for be 1:1 containing crude drug amount concentrate, let cool, 75% ethyl alcohol added to make alcohol content up to 60%, stand, ethanol extract is added in filtering, and concentration and recovery ethyl alcohol to ethanol content is less than 5%；Step 3: food calling preservative is just added in side stirring concentrate, and 30-60min is stirred after addition to stirring evenly；Step 4: concentrate pH is adjusted to faintly acid, after centrifugation, purified water is added and adjusts concentration to 1mL medical fluid 2.5g containing crude drug in whole, obtains oral solution, this method herbal medicine recovery rate is high, clarity of oral liquid is high, and effective component easily absorbs, and palatability is good, bioavilability is high, fungus and mildew resistance performance is strong, extends the shelf-life of oral solution, while can effectively improve pigling immunity.

Description

A kind of preparation method for the herbal medicine compound oral liquid improving pigling immunity
Technical field
The invention belongs to technical field of Chinese veterinary medicine, and in particular to a kind of herbal medicine compound oral liquid for improving pigling immunity Preparation method.
Background technique
Since early weaning piglet, feeding management are not good at, pig house environment health is bad, antisepsis system is not stringent, immune mistake Lose or other factors, pigling immunity caused to decline, can cause piglet bacillary diarrhea, virus diarrhea, parasitic diarrhea, Toxic diarrhea and irritability diarrhea etc., this disease incidence with higher and the death rate, bring great to pig breeding industry Loss.
The disease there is no effective immunization method at present, and drug therapy is still main means of prevention.For a long time, on veterinary clinic Antibacterial drug therapy is generallyd use, but with the prolonged application of antibiotic, generates antibody-resistant bacterium and lessens the curative effect, and drug is residual It stays, for this purpose, people are trying to explore not only have antibacterial action, but also there is the drug for adjusting human body immune function, for the disease Prevention and treatment.
It includes that mineral drug prevents and treats livestock and poultry or promotes growth of animal that Chinese herbal medicine for animals, which is using pure plant, Substance, since it will not generate the medicament residue being detrimental to health, so receiving the majority of consumers and livestock and poultry cultivation person Welcome.Relevant expert thinks that Chinese herbal medicine for animals largely will gradually take due to that food-safe will not constitute a threat to For chemicals.
The outstanding feature of herbal mixture is that volume is big, and chemical composition content is low, and comprehensive therapeutic effect is good.So curative effect to be made Height, dosage is small, the preparation of uniform specification, it is necessary to be eliminated the false and retained the true by extraction and refinement treatment with discarding the dross and selecting the essential.
Oral solution is liquid preparation for oral administration, with liquid, packing is carried out under conditions of cleaning keeps away bacterium；In order to guarantee The quality of preparation prevents the growth and breeding of microorganism, should add appropriate preservative appropriate, common preservative sodium benzoate and Sorbic acid, residual of the preservative in pork and products thereof bring very big damage to public health and food safety, are not inconsistent more The food consumption for closing people's " high-quality, low medicine residual, green non-pollution " becomes, and sodium benzoate can react with gastric acid, generates benzene Formic acid, benzoic acid have certain toxicity, edible for a long time to cause human body Chronic Benzene Poisoning, will cause bad shadow for health It rings；
Traditional Chinese medicine ingredients are complicated, and general taste is how bitter, puckery, salty, sour, pungent, therefore corrigent often need to additionally be added to a certain degree Upper cover and the bad smell for improving preparation, it is for oral administration convenient for piglet.
Summary of the invention
The purpose of the present invention is to provide a kind of preparation methods of herbal medicine compound oral liquid for improving pigling immunity, should Method herbal medicine recovery rate is high, and clarity of oral liquid is high, and effective component easily absorbs, and palatability is good, and bioavilability is high, and sterilization is anti- Mouldiness can be strong, extends the shelf-life of oral solution, while can effectively improve pigling immunity, the generation of keeping off infection property disease, Enhance the resistance to invasive organism and helminth, improve piglet survival ratio, promotes growth.
The purpose of the present invention can be achieved through the following technical solutions:
A kind of preparation method for the herbal medicine compound oral liquid improving pigling immunity, comprising the following steps:
Step 1: the component of Chinese veterinary medicinal composition is extracted, specifically: the Chinese bulbul, the coptis, Radix Paeoniae Alba, Rhizoma Atractylodis Macrocephalae second Alcohol reflux extracts, and reflux technique is to be flowed back 2 times, each 1.5h with 75% ethyl alcohol, and amount of alcohol is the Chinese bulbul, the coptis, Radix Paeoniae Alba, white 12 times of art total weight；Cortex Phellodendri, radix aucklandiae add water to cook soaking time 1.5h, and decocting number is 2 times, and decocting time 2h adds water Amount is Cortex Phellodendri, 15 times of radix aucklandiae total weight；
Step 2: water decoction is filtered, be concentrated for be 1:1 containing crude drug amount concentrate, let cool, 75% ethyl alcohol added to make to contain Alcohol amount is stood up to 60%, and ethanol extract is added in filtering, and concentration and recovery ethyl alcohol to ethanol content is less than 5%；
Step 3: food calling preservative is just added in side stirring concentrate, and 30-60min is stirred after addition to stirring evenly；
Step 4: pH adjusting agent being added into the concentrate that step 3 obtains, and adjusts pH to faintly acid, after centrifugation, is added Purified water adjusts concentration to 1mL medical fluid 2.5g containing crude drug in whole, obtains oral solution.
Further, the Chinese veterinary medicinal composition includes the component of following parts by weight: 8-12 parts of the Chinese bulbul, coptis 10- 15 parts, 5-8 parts of Radix Paeoniae Alba, 6-12 parts of Rhizoma Atractylodis Macrocephalae, 3-8 parts of Cortex Phellodendri, 2-5 parts of radix aucklandiae.
Various pharmacological actions:
The Chinese bulbul: having clearing heat and detoxicating, removes heat from the blood and relieve diarrhea, the effect of removing dampness and destroying parasites；The major functions: heat toxin dysentery, nosebleed epistaxis, bleeding, Leukorrhagia, pruritus vulvae, ulcerative carbuncle, scrofula.
The coptis: main component is berberine, and major function is heat-clearing and damp-drying drug, purging fire for removing toxin.Inside control damp and hot feeling of fullness, vomiting, Dysentery yellow subcutaneous ulcer, unconsciousness due to high fever, heart-fire hyperactivity, dysphoria and insomnia, hot eyes acid regurgitation, has a toothache, quenches one's thirst and carbuncle swells are treated and control eczema, wet outside sore Sore, purulent ear canal.
Radix Paeoniae Alba: there is nourishing blood for regulating menstruation, astringing YIN to stop sweating, soft liver analgesic, suppressing liver-YANG.The major functions: being used for blood deficiency chlorosis, menstruation is not It adjusts, spontaneous perspiration, night sweat, hypochondriac pain, abdominal pain, four limbs contraction pain, headache and dizziness.
Rhizoma Atractylodis Macrocephalae: strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis, miscarriage prevention are used for；The major functions: spleen eating less, abdominal distention diarrhea, phlegm retention anti-dazzle nervous, Oedema, spontaneous perspiration, threatened abortion；Rhizoma Atractylodis Macrocephalae invigorating the spleen, stomach function regulating, miscarriage prevention；For spleen eating less, diarrhea loose stool, threatened abortion.
Cortex Phellodendri: there is the effect of heat-clearing and damp-drying drug, purging intense heat, except steaming, detoxification sore treatment；The major functions: it is used for damp-heat dysentery, jaundice and reddish urine, Leukorrhagia pruritus vulvae, puckery pain of heat gonorrhea, tinea pedis impotence is preesed, hectic fever due to yin labor heat, night sweat, spermatorrhea, sore swollen toxin, eczema wet sore.
Radix aucklandiae: there is promoting qi circulation and relieving pain, reinforcing spleen to promote digestion；The major functions: promoting qi circulation and relieving pain；Promoting in tune；Main born of the same parents coerce turgor foot；Stomach duct and abdomen is swollen Bitterly；Spit diarrhea；Weight after dysentery；For chest gastral cavity distending pain, weight after rush down dysentery, dyspepsia, do not feel like eating；Middle gas does not save；Happen suddenly ear It is deaf；Snakebite and bugbite；Toothache.
Further, the additional amount of the food calling preservative is the 0.1% of concentrate total weight.
Further, the food calling preservative the preparation method comprises the following steps:
The preparation of S1, bisabolene derivative
Bisabolene, methyl succinate and catalyst iodine are added in autoclave, nitrogen is passed through and displaces pressure Air in reaction kettle, closed heating are warming up to 200 DEG C with the speed of 10 DEG C/min, keep the temperature 2h, using silica gel post separation, divide Exsolution liquid is vol/vol methanol: 1% potassium dihydrogen phosphate aqueous solution=65:35 is to get having arrived formula a bisabolene derivative；Instead Answer formula as follows:
The preparation of S2, food calling preservative
Bisabolene derivative a is added in reaction flask, 20% aqueous hydrochloric acid solution is added, is continued at 65-75 DEG C 2h is stirred, bisabolene derivative a issues raw hydrolysis in acid solution, obtained the food calling preservative of formula b structure, reaction equation It is as follows:
The light happiness of bisabolene fragrance, is used for animal perfume material food calling, and the present invention is by bisabolene and methyl succinate Reaction then has obtained both having effects that food calling containing there are two the food calling preservative of carboxylic acid, being not required to additionally add any through hydrolysis Corrigent can also reduce cost in production, while introduce two carboxylic acids, increase antisepsis and sterilization performance, and in structure Without benzene ring structure, medicament residue will not be caused.
Further, in step S1, the molar ratio of bisabolene, methyl succinate and catalyst iodine is 1:1.1-1.5: 0.001-0.003。
Further, in step S2, the additional amount of 20% aqueous hydrochloric acid solution is 2-5 times of bisabolene derivative a weight.
Further, the sodium hydrate aqueous solution that the pH adjusting agent is 10%.
Further, adjusting pH to faintly acid is specially to adjust pH as 5.5-6.5.
Influence of the pH value to oral solution is very big, and traditional Chinese medicine oral liquid pH value and clarity are closely related, and reflection oral solution The important references numerical value of presentation quality, oral solution pH of the present invention are 5.5-6.5, and clarity of oral liquid is preferable, and are placed for a long time It is not precipitated, illustrates that the effective component of Chinese medicine composition solubility under the conditions of weakly acidic is preferable, be easy to the absorption of piglet.
Beneficial effects of the present invention:
The present invention provides a kind of preparation method of herbal medicine compound oral liquid for improving pigling immunity, herbal medicine is extracted Rate is high, and clarity of oral liquid is high, and effective component easily absorbs, and palatability is good, and bioavilability is high, and fungus and mildew resistance performance is strong, extends The shelf-life of oral solution, while pigling immunity can be effectively improved, the generation of keeping off infection property disease enhances to pathogenic micro- The resistance of biology and helminth improves piglet survival ratio, promotes growth.
Specific embodiment
The technical scheme in the embodiments of the invention will be clearly and completely described below, it is clear that described implementation Example is only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, this field is common Technical staff's all other embodiment obtained without creative efforts belongs to the model that the present invention protects It encloses.
In following embodiments, food calling preservative the preparation method comprises the following steps:
The preparation of S1, bisabolene derivative
1moL bisabolene, 1.2moL methyl succinate and 0.002moL catalyst iodine are added in autoclave, It being passed through nitrogen and displaces air in pressure reaction still, closed heating is warming up to 200 DEG C with the speed of 10 DEG C/min, keeps the temperature 2h, Using silica gel post separation, separation solution is vol/vol methanol: 1% potassium dihydrogen phosphate aqueous solution=65:35 is to get having arrived formula a Bisabolene derivative；Reaction equation is as follows:
The preparation of S2, food calling preservative
Bisabolene derivative a is added in reaction flask, 20% aqueous hydrochloric acid solution, 20% aqueous hydrochloric acid solution is added Additional amount be 3 times of bisabolene derivative a weight, continue to stir 2h at 70 DEG C, bisabolene derivative a is in acid solution Raw hydrolysis is issued, the food calling preservative of formula b structure has been obtained, reaction equation is as follows:
The mass spectral results of gained food calling preservative b are as follows: HRMS m/z (ESI+)calcd for C19H28O4([M]+), 321.22,found 321.2137。
Embodiment 1
A kind of preparation method for the herbal medicine compound oral liquid improving pigling immunity, comprising the following steps:
Step 1: the component of Chinese veterinary medicinal composition is extracted, specifically: the Chinese bulbul, the coptis, Radix Paeoniae Alba, Rhizoma Atractylodis Macrocephalae second Alcohol reflux extracts, and reflux technique is to be flowed back 2 times, each 1.5h with 75% ethyl alcohol, and amount of alcohol is the Chinese bulbul, the coptis, Radix Paeoniae Alba, white 12 times of art total weight；Cortex Phellodendri, radix aucklandiae add water to cook soaking time 1.5h, and decocting number is 2 times, and decocting time 2h adds water Amount is Cortex Phellodendri, 15 times of radix aucklandiae total weight；
Step 2: water decoction is filtered, be concentrated for be 1:1 containing crude drug amount concentrate, let cool, 75% ethyl alcohol added to make to contain Alcohol amount is stood up to 60%, and ethanol extract is added in filtering, and concentration and recovery ethyl alcohol to ethanol content is less than 5%；
Step 3: food calling preservative is just added in side stirring concentrate, and the additional amount of preservative is concentrate total weight 0.1%, 30min is stirred after addition to stirring evenly；
Step 4: the sodium hydrate aqueous solution of pH adjusting agent 10% being added into the concentrate that step 3 obtains, and adjusts pH It is 5.5, after centrifugation, purified water is added and adjusts concentration to 1mL medical fluid 2.5g containing crude drug in whole, obtains oral solution.
The Chinese veterinary medicinal composition includes the component of following parts by weight: 8 parts of the Chinese bulbul, 15 parts of the coptis, 5 parts of Radix Paeoniae Alba, 10 parts of Rhizoma Atractylodis Macrocephalae, 8 parts of Cortex Phellodendri, 2 parts of radix aucklandiae.
Embodiment 2
A kind of preparation method for the herbal medicine compound oral liquid improving pigling immunity, comprising the following steps:
Step 1: the component of Chinese veterinary medicinal composition is extracted, specifically: the Chinese bulbul, the coptis, Radix Paeoniae Alba, Rhizoma Atractylodis Macrocephalae second Alcohol reflux extracts, and reflux technique is to be flowed back 2 times, each 1.5h with 75% ethyl alcohol, and amount of alcohol is the Chinese bulbul, the coptis, Radix Paeoniae Alba, white 12 times of art total weight；Cortex Phellodendri, radix aucklandiae add water to cook soaking time 1.5h, and decocting number is 2 times, and decocting time 2h adds water Amount is Cortex Phellodendri, 15 times of radix aucklandiae total weight；
Step 2: water decoction is filtered, be concentrated for be 1:1 containing crude drug amount concentrate, let cool, 75% ethyl alcohol added to make to contain Alcohol amount is stood up to 60%, and ethanol extract is added in filtering, and concentration and recovery ethyl alcohol to ethanol content is less than 5%；
Step 3: food calling preservative is just added in side stirring concentrate, and the additional amount of preservative is concentrate total weight 0.1%, 60min is stirred after addition to stirring evenly；
Step 4: the sodium hydrate aqueous solution of pH adjusting agent 10% being added into the concentrate that step 3 obtains, and adjusts pH It is 6.5, after centrifugation, purified water is added and adjusts concentration to 1mL medical fluid 2.5g containing crude drug in whole, obtains oral solution.
The Chinese veterinary medicinal composition includes the component of following parts by weight: 12 parts of the Chinese bulbul, 10 parts of the coptis, 5 parts of Radix Paeoniae Alba, 6 parts of Rhizoma Atractylodis Macrocephalae, 8 parts of Cortex Phellodendri, 5 parts of radix aucklandiae.
Embodiment 3
A kind of preparation method for the herbal medicine compound oral liquid improving pigling immunity, comprising the following steps:
Step 1: the component of Chinese veterinary medicinal composition is extracted, specifically: the Chinese bulbul, the coptis, Radix Paeoniae Alba, Rhizoma Atractylodis Macrocephalae second Alcohol reflux extracts, and reflux technique is to be flowed back 2 times, each 1.5h with 75% ethyl alcohol, and amount of alcohol is the Chinese bulbul, the coptis, Radix Paeoniae Alba, white 12 times of art total weight；Cortex Phellodendri, radix aucklandiae add water to cook soaking time 1.5h, and decocting number is 2 times, and decocting time 2h adds water Amount is Cortex Phellodendri, 15 times of radix aucklandiae total weight；
Step 2: water decoction is filtered, be concentrated for be 1:1 containing crude drug amount concentrate, let cool, 75% ethyl alcohol added to make to contain Alcohol amount is stood up to 60%, and ethanol extract is added in filtering, and concentration and recovery ethyl alcohol to ethanol content is less than 5%；
Step 3: food calling preservative is just added in side stirring concentrate, and the additional amount of preservative is concentrate total weight 0.1%, 50min is stirred after addition to stirring evenly；
Step 4: the sodium hydrate aqueous solution of pH adjusting agent 10% being added into the concentrate that step 3 obtains, and adjusts pH It is 6.1, after centrifugation, purified water is added and adjusts concentration to 1mL medical fluid 2.5g containing crude drug in whole, obtains oral solution.
The Chinese veterinary medicinal composition includes the component of following parts by weight: 11 parts of the Chinese bulbul, 12 parts of the coptis, 7 parts of Radix Paeoniae Alba, 12 parts of Rhizoma Atractylodis Macrocephalae, 6 parts of Cortex Phellodendri, 4 parts of radix aucklandiae.
Comparative example 1
The food calling preservative is sodium benzoate, remaining is the same as embodiment 3.
Comparative example 2
The food calling preservative is sorbic acid, remaining is the same as embodiment 3.
1, the antibacterial and mouldproof performance test of herbal medicine compound oral liquid:
Each 50mL of additive samples made from embodiment 1-3 and comparative example 1-2 is weighed, is sterilized through pasteurization Afterwards, it is separately added into the container of sterilizing, 500g culture solution is then added in each container, be inoculated with a certain amount of golden yellow grape respectively Coccus, Escherichia coli, pseudomonas aeruginosa, Aspergillus terreus, green ochre mould, aspergillus niger are cultivated 7 days at being 35 DEG C in room temperature, are calculated Bacteriostasis rate；
The antibacterial and mouldproof results of property of table 1, herbal medicine compound oral liquid
As shown in Table 1, oral solution of the invention considerably increases the antibacterial of oral solution due to the addition of food calling preservative b Fungicidal properties.
2, grice diarrhoea is treated, pigling immunity experiment is improved
The piglet case 100 (3-15 age in days) through making a definite diagnosis infection colibacillosis of piglet diarrhea is chosen, is randomly divided into 5 Group, 5 groups of piglet cases is carried out respectively to gavage administration, dosage is 1.0mL/kg.w, continuous use by every group 20 3 days, 1 time a day, clinical observation 3 days after the completion of medication observed and recorded incidence, the clinical symptoms of each group case daily (including perianal dirt, excrement situation, the state of mind, appetite etc.) and death condition, test result are shown in Table 2:
Table 2, treatment grice diarrhoea, improve pigling immunity experimental result
Clinical test results show described in technical scheme 1,2,3 group of preparation to piglet abdomen caused by Escherichia coli The clinical cure rate for rushing down disease is respectively 90%, 95%, 95%, and 4,5 groups, cure rate is respectively 65%, 75%, the application Piglet is without death in 1,2,3 group of the preparation, and to use 4,5 groups of the piglet death rate of traditional preservatives be respectively 20%, 15%, the results showed that the compound oral liquid of the application preparation can effectively treat grice diarrhoea, to improve pigling immunity.
The above content is just an example and description of the concept of the present invention, affiliated those skilled in the art It makes various modifications or additions to the described embodiments or is substituted in a similar manner, without departing from invention Design or beyond the scope defined by this claim, be within the scope of protection of the invention.

Claims (8)

1. a kind of preparation method for the herbal medicine compound oral liquid for improving pigling immunity, it is characterised in that: the following steps are included:
Step 1: the component of Chinese veterinary medicinal composition is extracted, specifically: the Chinese bulbul, the coptis, Radix Paeoniae Alba, Rhizoma Atractylodis Macrocephalae are returned with ethyl alcohol Stream extracts, and reflux technique is to be flowed back 2 times, each 1.5h with 75% ethyl alcohol, and amount of alcohol is that the Chinese bulbul, the coptis, Radix Paeoniae Alba, Rhizoma Atractylodis Macrocephalae are total 12 times of weight；Cortex Phellodendri, radix aucklandiae add water to cook soaking time 1.5h, and decocting number is 2 times, decocting time 2h, and amount of water is Cortex Phellodendri, 15 times of radix aucklandiae total weight；
Step 2: water decoction is filtered, be concentrated for be 1:1 containing crude drug amount concentrate, let cool, 75% ethyl alcohol added to make alcohol content It up to 60%, stands, filtering, ethanol extract is added in filtrate, concentration and recovery ethyl alcohol to ethanol content is less than 5%；
Step 3: food calling preservative is just added in side stirring concentrate, and 30-60min is stirred after addition to stirring evenly；
Step 4: pH adjusting agent being added into the concentrate that step 3 obtains, and adjusts pH to faintly acid, after centrifugation, purifying is added Water adjusts concentration to 1mL medical fluid 2.5g containing crude drug in whole, obtains oral solution.
2. a kind of preparation method of herbal medicine compound oral liquid for improving pigling immunity according to claim 1, special Sign is: the Chinese veterinary medicinal composition includes the component of following parts by weight: 8-12 parts of the Chinese bulbul, 10-15 parts of the coptis, Radix Paeoniae Alba 5-8 parts, 6-12 parts of Rhizoma Atractylodis Macrocephalae, 3-8 parts of Cortex Phellodendri, 2-5 parts of radix aucklandiae.
3. a kind of preparation method of herbal medicine compound oral liquid for improving pigling immunity according to claim 1, special Sign is: the additional amount of the food calling preservative is the 0.1% of concentrate total weight.
4. a kind of preparation method of herbal medicine compound oral liquid for improving pigling immunity according to claim 1, special Sign is: the food calling preservative the preparation method comprises the following steps:
The preparation of S1, bisabolene derivative
Bisabolene, methyl succinate and catalyst iodine are added in autoclave, nitrogen is passed through and displaces pressure reaction Air in kettle, closed heating are warming up to 200 DEG C with the speed of 10 DEG C/min, keep the temperature 2h, using silica gel post separation, separate molten Liquid is vol/vol methanol: 1% potassium dihydrogen phosphate aqueous solution=65:35 is to get having arrived formula a bisabolene derivative；Reaction equation It is as follows:
The preparation of S2, food calling preservative
Bisabolene derivative a is added in reaction flask, 20% aqueous hydrochloric acid solution is added, continues to stir at 65-75 DEG C 2h, bisabolene derivative a issue raw hydrolysis in acid solution, have obtained the food calling preservative of formula b structure, reaction equation is such as Under:
5. a kind of preparation method of herbal medicine compound oral liquid for improving pigling immunity according to claim 4, special Sign is: in step S1, the molar ratio of bisabolene, methyl succinate and catalyst iodine is 1:1.1-1.5:0.001-0.003.
6. a kind of preparation method of herbal medicine compound oral liquid for improving pigling immunity according to claim 4, special Sign is: in step S2, the additional amount of 20% aqueous hydrochloric acid solution is 2-5 times of bisabolene derivative a weight.
7. a kind of preparation method of herbal medicine compound oral liquid for improving pigling immunity according to claim 1, special Sign is: the sodium hydrate aqueous solution that the pH adjusting agent is 10%.
8. a kind of preparation method of herbal medicine compound oral liquid for improving pigling immunity according to claim 1, special Sign is: adjusting pH to faintly acid is specially to adjust pH as 5.5-6.5.
CN201811535508.6A 2018-12-14 2018-12-14 A kind of preparation method for the herbal medicine compound oral liquid improving pigling immunity Pending CN109331078A (en)

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CN106031755A (en) * 2015-03-12 2016-10-19 杜乃龙 A formula treating bacillary dysentery
CN108774789A (en) * 2018-08-02 2018-11-09 李萌 A kind of antibacterial anti-anaphylaxis functional fabric

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Publication number Priority date Publication date Assignee Title
CN1451429A (en) * 2003-05-08 2003-10-29 林少彬 Chinese medicine for treating bacillary dysentery and producing method thereof
CN102210770A (en) * 2011-05-31 2011-10-12 鲍旭刚 Medicament for treating dysentery, and preparation method thereof
CN106031755A (en) * 2015-03-12 2016-10-19 杜乃龙 A formula treating bacillary dysentery
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Application publication date: 20190215