CN109320517A - Fxr受体激动剂 - Google Patents
Fxr受体激动剂 Download PDFInfo
- Publication number
- CN109320517A CN109320517A CN201710639245.2A CN201710639245A CN109320517A CN 109320517 A CN109320517 A CN 109320517A CN 201710639245 A CN201710639245 A CN 201710639245A CN 109320517 A CN109320517 A CN 109320517A
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- Prior art keywords
- alkyl
- ring
- base
- amino
- alkoxy
- Prior art date
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- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 14
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- 125000003548 sec-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
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- 229910001948 sodium oxide Inorganic materials 0.000 description 1
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- JVCCJEOHXPAYHK-DTORHVGOSA-N tert-butyl (1s,5r)-3-oxo-8-azabicyclo[3.2.1]oct-6-ene-8-carboxylate Chemical compound C1C(=O)C[C@@H]2C=C[C@H]1N2C(=O)OC(C)(C)C JVCCJEOHXPAYHK-DTORHVGOSA-N 0.000 description 1
- IZPYBIJFRFWRPR-UHFFFAOYSA-N tert-butyl pyrrole-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1C=CC=C1 IZPYBIJFRFWRPR-UHFFFAOYSA-N 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 125000005958 tetrahydrothienyl group Chemical group 0.000 description 1
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- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
Abstract
Description
Claims (13)
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CN109265471A (zh) * | 2017-06-30 | 2019-01-25 | 海南轩竹医药科技有限公司 | Fxr受体激动剂 |
CN111825701A (zh) * | 2019-04-19 | 2020-10-27 | 正大天晴药业集团股份有限公司 | 含苯并噻唑的三环类fxr调节剂化合物 |
CN113024552A (zh) * | 2021-03-26 | 2021-06-25 | 厦门市博瑞来医药科技有限公司 | 一类新型非甾体fxr激动剂的合成及其应用 |
US11208418B2 (en) | 2018-02-02 | 2021-12-28 | Sunshine Lake Pharma Co., Ltd. | Nitrogenous tricyclic compounds and uses thereof in medicine |
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CN113024552A (zh) * | 2021-03-26 | 2021-06-25 | 厦门市博瑞来医药科技有限公司 | 一类新型非甾体fxr激动剂的合成及其应用 |
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Address after: 570105 Tianyi International Building, 85 Binhai Avenue, Longhua District, Haikou City, Hainan Province, 27th Floor Applicant after: Xuanzhu (Hainan) Pharmaceutical Technology Co., Ltd. Address before: 570105 Tianyi International Building, 85 Binhai Avenue, Longhua District, Haikou City, Hainan Province, 27th Floor Applicant before: Hainan Xuanzhu Pharmaceutical Technology Co., Ltd. |
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Address after: 050000 Beijing Tianjin Hebei Collaborative Innovation Demonstration Park, 769 Taihang street, high tech Zone, Shijiazhuang City, Hebei Province 203c507 Applicant after: Xuanzhu Biotechnology Co., Ltd Address before: 570105 Tianyi International Building, 85 Binhai Avenue, Longhua District, Haikou City, Hainan Province, 27th Floor Applicant before: Xuanzhu (Hainan) Pharmaceutical Technology Co.,Ltd. |
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Inventor after: Shi Chengkong Inventor after: Xu Yanjun Inventor before: Shi Chengkong |
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Address after: 050000 Beijing Tianjin Hebei Collaborative Innovation Demonstration Park 203c507, 769 Taihang street, high tech Zone, Shijiazhuang City, Hebei Province Patentee after: Xuanzhu Biotechnology Co.,Ltd. Address before: 050000 Beijing Tianjin Hebei Collaborative Innovation Demonstration Park 203c507, 769 Taihang street, high tech Zone, Shijiazhuang City, Hebei Province Patentee before: Xuanzhu Biotechnology Co.,Ltd. |
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