CN109298149B - Efficient automatic release rate sampling system - Google Patents
Efficient automatic release rate sampling system Download PDFInfo
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- CN109298149B CN109298149B CN201811336778.4A CN201811336778A CN109298149B CN 109298149 B CN109298149 B CN 109298149B CN 201811336778 A CN201811336778 A CN 201811336778A CN 109298149 B CN109298149 B CN 109298149B
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- 238000005070 sampling Methods 0.000 title claims abstract description 41
- 239000002904 solvent Substances 0.000 claims abstract description 126
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 29
- 239000003814 drug Substances 0.000 claims description 47
- 239000002775 capsule Substances 0.000 claims description 35
- 238000007789 sealing Methods 0.000 claims description 33
- 239000011505 plaster Substances 0.000 claims description 17
- 238000001704 evaporation Methods 0.000 claims description 13
- 239000002184 metal Substances 0.000 claims description 10
- 230000033001 locomotion Effects 0.000 abstract description 22
- 230000002496 gastric effect Effects 0.000 abstract description 13
- 230000008855 peristalsis Effects 0.000 abstract description 13
- 238000004090 dissolution Methods 0.000 abstract description 12
- 230000000694 effects Effects 0.000 abstract description 6
- 230000000968 intestinal effect Effects 0.000 abstract description 5
- 229940079593 drug Drugs 0.000 description 33
- 238000000034 method Methods 0.000 description 32
- 210000001035 gastrointestinal tract Anatomy 0.000 description 7
- 238000002474 experimental method Methods 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 238000010521 absorption reaction Methods 0.000 description 5
- 238000013461 design Methods 0.000 description 4
- 239000002552 dosage form Substances 0.000 description 4
- 230000008020 evaporation Effects 0.000 description 4
- 239000011521 glass Substances 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 4
- 230000000747 cardiac effect Effects 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000003111 delayed effect Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 238000004088 simulation Methods 0.000 description 2
- 238000000935 solvent evaporation Methods 0.000 description 2
- 230000003068 static effect Effects 0.000 description 2
- 230000000699 topical effect Effects 0.000 description 2
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000007922 dissolution test Methods 0.000 description 1
- 239000013583 drug formulation Substances 0.000 description 1
- 230000036267 drug metabolism Effects 0.000 description 1
- 229940088679 drug related substance Drugs 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 235000012631 food intake Nutrition 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The high-efficiency automatic release rate sampling system is characterized by comprising a base, a water tank, a vertical moving mechanism, a horizontal moving mechanism, a controller, a display, a sampling bracket, an inner tube placing frame, an inner tube, an outer solvent tube and an outer solvent tube placing plate; the invention simulates intestinal peristalsis in a mode of up-and-down movement, the inner tube simulates the gastrointestinal environment in a human body by adopting the mode of up-and-down movement of the solvent outer tube, the inner tube moves up-and-down in the solvent outer tube, the dissolution force is strong, the intestinal peristalsis is more fit with the gastrointestinal peristalsis mode, and the gastrointestinal peristalsis environment is more properly simulated by adopting the mode of up-and-down movement, and the experimental effect is good.
Description
Technical Field
The invention belongs to the technical field of medicine research and development and quality control test detection equipment, and particularly relates to a high-efficiency automatic release rate sampling system.
Background
In order to produce a desired pharmacological effect, the drug must be made available in the body at an appropriate concentration at its site of action. Such effectiveness is affected by a number of factors, including: the amount of drug administered, the rate of drug absorption, the partitioning (binding or localization) in tissue, drug metabolism, and elimination from the body.
As a method for inspecting drug properties, dissolution inspection plays an important role in the evaluation of quality consistency when a drug formulation is changed after approval, and the like. The United states pharmacopoeia divides the drug dissolution and release device into 1-7 methods, wherein the third method is a reciprocating cylinder method for measuring drug tablet and capsule dissolution; the seventh method is a reciprocating stent method, and is used for a dissolution measuring device for ointments, plaster patches and cardiac stents.
Most of devices for testing drug release rate in the current market are dissolution instruments, and in the actual use process, workers find the following defects:
1. when the existing dissolution instrument is used, a single reciprocating cylinder method or a single reciprocating bracket method is adopted, so that medicines in the two methods cannot be measured simultaneously, and the using method is single.
2. The traditional dissolution instrument is characterized in that medicines are placed in a medicine basket, the medicine basket is placed in a solvent outer tube, the solvent outer tube is used for simulating the gastrointestinal environment in a human body, the medicine basket rotates in the solvent outer tube, and the rotation mode is used for simulating gastrointestinal peristalsis of the human body. However, in experiments, the dissolution force is insufficient in the first mode of rotating the medicine basket, on the other hand, the gastrointestinal peristalsis is not rotary motion, the simulation of the gastrointestinal peristalsis environment by rotation is not proper, and the experimental effect is poor.
3. For oral administration of pharmaceutical dosage forms, drug absorption occurs in the gastrointestinal tract. During passage through the gastrointestinal tract, the drug should be released from the dosage form and be available in solution at or near the desired absorption site. The rate at which the drug is released from a dosage form and into solution is important for the kinetics of drug absorption. The dosage form and thus the drug is subjected to a change in pH during this passage, for example from about pH1.2 (during fasting-but the pH of the stomach increases to as high as 4.0 after food consumption) to about 7.4 in the other parts of the digestive tract (bile pH:7.0-7.4 and intestinal pH:5 to 7). Other factors affecting drug absorption include the physicochemical properties of the drug substance itself such as its pKa, solubility, crystallization energy, and specific surface area, as well as the characteristics of the gastrointestinal tract itself such as the characteristics of the luminal components (pH, surface tension, volume, stirring and buffering capacity) and changes that occur after ingestion of food.
Therefore, when performing a dissolution test, it is often necessary to perform a full simulation of each part of the stomach and the intestinal tract, and this process requires a plurality of solvent outer tubes, even a plurality of solvent outer tubes, and most of the prior dissolution devices use the same solvent outer tube during one test, and require taking out the drug basket and replacing the solvent outer tube during the environment changing of the drug, so that errors occur in the test time, and inaccurate test data are easily caused.
Disclosure of Invention
In order to solve the problems, the invention discloses a high-efficiency automatic release rate sampling system, which has the following specific technical scheme:
the high-efficiency automatic release rate sampling system is characterized by comprising a base, a water tank, a vertical moving mechanism, a horizontal moving mechanism, a controller, a display, a sampling bracket, an inner tube placing frame, an inner tube, an outer solvent tube and an outer solvent tube placing plate;
the base is used for installing the water tank, the horizontal moving mechanism and the vertical moving mechanism; the base comprises a bottom plate and two side plates, the two side plates are vertically and symmetrically distributed and fixed on two sides of the bottom plate, and the water tank is fixedly arranged between the two side plates; the water tank is internally provided with water, and the top of the water tank is of an opening structure;
the controller is electrically connected with the display, the vertical moving mechanism and the horizontal moving mechanism through cables, and is used for controlling the vertical moving mechanism and the horizontal moving mechanism to move, and the display is used for displaying controller signals;
the horizontal moving mechanism comprises a horizontal linear module, a bottom sliding mechanism, a side connecting plate and a side fixing structure; the horizontal linear modules are arranged horizontally, the number of the horizontal linear modules is two, the horizontal linear modules are arranged on two base side plates, support columns are fixedly arranged at two ends of each side plate of the base, and the two ends of each horizontal linear module are respectively fixed on the support columns; the horizontal linear module is provided with a sliding block, one side of the sliding block on the horizontal linear module is fixedly connected with the side connecting plate, the number of the side connecting plates is two, the two side connecting plates are fixedly connected with the sliding blocks of the two horizontal linear modules respectively, and one side connecting plate is fixedly connected with the display and the controller;
the bottom sliding mechanism comprises two bottom supporting plates, three bottom sliding columns, three bottom sliding blocks and a bottom connecting plate; the number of the bottom support plates is two, and the bottom support plates are vertically arranged at two ends of the bottom of the base bottom plate; the bottom sliding column is of a cylindrical structure, two ends of the bottom sliding column are fixedly connected to the two bottom supporting plates, through holes are formed in the bottom sliding blocks, the bottom sliding blocks penetrate through the bottom sliding column through the through holes to realize sliding connection on the bottom sliding column, the bottom connecting plate is of a strip-shaped plate body structure, two ends of the bottom connecting plate are fixedly connected with bottoms of the two side connecting plates, and three bottom sliding blocks are fixedly connected with the bottom connecting plate;
the vertical moving mechanism comprises a connecting frame, a vertical fixing column and a vertical linear module; the connecting frame is of a square plate body structure, two sides of the connecting frame are respectively and fixedly connected with two sides of the top of the side connecting plate, the number of the vertical fixing columns is one, the connecting frame is of a square column body structure, and the vertical fixing columns are vertically arranged in the middle position of the top of the connecting frame; the vertical linear modules are linear modules, the number of the linear modules is one, and the linear modules are vertically arranged on one side of the vertical fixing column; the sliding block is arranged on the vertical linear module, and the sliding block of the vertical linear module is fixedly connected with the inner tube placing frame;
the inner tube placing frame comprises a vertical plate, a horizontal plate and a placing plate; the vertical plate is vertically arranged, one side of the top is fixedly connected with a sliding block of the vertical linear module, the other side of the bottom is fixedly connected with a horizontal plate, a plurality of inner tube mounting through holes which are vertically arranged are formed in the mounting plate, the inner tube mounting through holes are used for mounting inner tubes, a connecting rod is arranged at the top of each inner tube, passes through the inner tube mounting through holes, and is fixed on the mounting plate through bolts and nuts, and the central position of one side of the mounting plate is fixedly connected with the horizontal plate;
the sampling support is arranged on one side of the connecting frame, the sampling support is of an integrated structure and comprises a bottom fixing column and a placing plate, the placing plate is horizontally arranged, a plurality of round holes are formed in the placing plate and used for placing sampling pipes, the bottom fixing column is of an inclined structure, the top of the bottom fixing column is fixedly connected with one side of the placing plate, and the bottom of the bottom fixing column is fixedly connected with the top of the connecting frame;
the solvent outer tube is placed in the water tank, the top ends of the two supporting columns on one base side are fixedly connected with a solvent outer tube supporting plate, a plurality of fixing protrusion groups are fixedly arranged on each solvent outer tube supporting plate, and each fixing protrusion group comprises two fixing protrusions;
the solvent outer tube placing plates are of long-strip-shaped structures, the number of the solvent outer tube placing plates is a plurality of the solvent outer tube placing plates is an integral structure, a plurality of solvent outer tube placing through holes are uniformly formed in the solvent outer tube placing plates, and the solvent outer tubes are fixed on the solvent outer tube placing plates through the solvent outer tube placing through holes; two ends of the solvent outer tube placing plate are provided with a U-shaped connecting plate, one side of the U-shaped connecting plate is fixedly connected with the solvent outer tube placing plate, the two U-shaped connecting plates are symmetrically distributed at two ends of the solvent outer tube placing plate, the top and the bottom of the U-shaped connecting plate are respectively provided with two through holes, and the positions of the through holes on the U-shaped connecting plate correspond to the positions of the fixing protrusions; the solvent outer tube placing plate is embedded into the through hole on the U-shaped connecting plate through the fixing protrusion to be detachably fixed with the base;
the solvent outer tube placing plate is placed above the water tank, and the solvent outer tube is arranged inside the water tank through the solvent outer tube placing plate.
Further, the inner tube is one of a tablet capsule inner tube, a first patch inner tube, a second patch inner tube, a heart support inner tube and a plaster inner tube.
Further, the tablet capsule inner tube comprises an inner tube body and a cover, the inner tube body is a hollow tube body, external threads are arranged at the bottom of the inner tube body, the shape and the size of the cover correspond to those of the bottom of the inner tube body, internal threads are arranged on the inner side of the cover, the cover is detachably connected with the external threads through matching of the internal threads, and a filter screen is arranged at the center of the bottom of the cover; the connecting pipe connected to the tablet capsule inner pipe is of a hollow structure, a waist-shaped hole is formed in one side of the bottom of the connecting pipe, sampling is needed when the tablet capsule inner pipe is used, and a sampling hose is inserted into the waist-shaped hole, so that a medicine collecting hose stretches into the tablet capsule to carry out a walking line.
Further, the first patch inner tube is of a circular cylinder structure, and a circular inner hole is formed in the first patch inner tube.
Further, the second patch inner tube is of a circular cylinder structure, an annular groove is formed in the outer surface of the second patch inner tube, and an elastic ring is arranged in the annular groove.
Further, heart support inner tube includes upper plate, lower ring, bottom and spliced pole, the upper plate is circular plate body structure, the lower ring is ring shape structure, upper plate and lower ring size, shape are corresponding, the upper plate corresponds the setting from top to bottom with lower ring, spliced pole quantity is a plurality of, spliced pole top and upper plate fixed connection, bottom and lower ring fixed connection, the spliced pole is circular evenly distributed between upper column and lower ring, lower ring bottom periphery is provided with the external screw thread, the bottom is circular lid structure, be provided with the internal thread on the inboard all around of bottom, realize dismantling through internal and external screw thread cooperation between lower ring and the bottom and be connected, be provided with a plurality of circular through-holes on the bottom.
Further, the plaster inner tube comprises a bottom plate and a metal spring, one side of the top of the metal spring is fixedly connected with the connecting column, and the bottom surface of the bottom of the metal spring is fixedly connected with the bottom plate.
Further, a conical anti-evaporation cover is arranged on the solvent outer tube and comprises an elastic cover body made of rubber, the elastic cover body comprises an outer jacket and an inner sealing column, and a sealing groove is arranged between the outer jacket and the inner sealing column; the outer envelope and the inner envelope column are of an integrated structure, the outer envelope is in a circular tube shape, the cross section of the outer envelope is in a circular ring shape, the inner Feng Zhu is in a cylinder shape, and the lower end of the cylinder shape is in a conical shape; the sealing groove is positioned between the outer envelope and the inner sealing column, the cross section of the sealing groove is circular, the upper end of the sealing groove is provided with a sealing groove, the sealing groove is circular, and the longitudinal section of the sealing groove is omega-shaped.
Further, the number of the solvent outer tube placing plates is the same as the number of the fixing protrusion groups.
Further, the side connecting plates are of trapezoid structures.
Further, the fixing protrusion is of an integrated structure, the bottom of the fixing protrusion is a cylinder, and the top of the fixing protrusion is of a hemispherical structure.
The patent application working flow of the invention is as follows:
1. and (3) preparing the corresponding inner tube for medicament, wherein all accessories are in a usable state.
2. The controller is started, the inner tube reaches the first row through the horizontal moving mechanism, the first row of evaporation preventing covers are opened, and the inner tube descends into the solvent outer tube through the vertical moving mechanism (the solvent is already put into the solvent outer tube).
3. The inner tube is static in the solvent outer tube for a period of time (range: 1-5 min) to adapt to the current solvent.
4. Moves up and down according to a set speed (the lifting speed range is 4-50 times/min plus or minus 0.5 times/min).
5. After the set time (0-99 h99min99 s) is reached, the inner tube is raised to the set point (0-100 mm), and is stationary for a period of time (range: 1-10 min), and the solvent in the inner tube is dropped into the outer tube.
6. Reaching the next row, and repeating the experimental process of 2-5;
7. after all 6 rows are finished, the movement can be continued from the second row, and 20 samples can be taken at most.
The beneficial effects of the invention are as follows:
1. the tablet capsule inner tube, the first patch inner tube, the second patch inner tube, the heart support inner tube and the plaster inner tube can be applied to a reciprocating cylinder method and a reciprocating support method, can be used for simultaneously measuring medicines in two methods, and are rich in use methods;
when the reciprocating tube method is used for sampling the release rate of the tablet capsule, the drug tablet or the capsule drug to be tested is placed in the tablet capsule inner tube, if the tablet is smaller, a glass ball can be placed in the tablet capsule inner tube, and the drug tablet or the capsule drug is placed in the glass ball, so that the drug tablet or the capsule drug is fixed in the tablet capsule inner tube, and the test and detection are realized;
the reciprocating bracket method is used for sampling the release rate of plaster, external patch and heart bracket, when in use, the large-area external patch uses the first patch inner tube, the patch medicine surface is outwards, and the medicine-free surface is stuck on the outer wall of the first patch inner tube, so as to realize measurement; the small-area external patch uses a second patch inner tube, the patch medicine surface faces outwards, the medicine-free surface contacts with the outer wall of the second patch tube, and then the elastic ring is sleeved outside the patch and embedded in the annular groove, so that the external patch is fixed outside the second patch inner tube; the heart stent uses the heart stent inner tube, the heart stent is placed between the middle columns, and the bottom cover is screwed tightly; the thick topical plaster can be applied by placing the inner tube of the plaster.
2. The invention simulates intestinal peristalsis by adopting a mode of up-and-down movement, wherein the inner tube adopts a mode of up-and-down movement (the up-and-down movement amplitude of a reciprocating cylinder method is 10CM; the up-and-down movement amplitude of a reciprocating bracket method is 2 CM) in the solvent outer tube, the solvent outer tube is used for simulating the gastrointestinal environment in a human body, the inner tube moves up and down in the solvent outer tube, the dissolution force is strong, on the other hand, the inner tube is more suitable for the gastrointestinal peristalsis mode, and the up-and-down movement mode is used for simulating the gastrointestinal peristalsis environment, so that the experimental effect is good.
3. The multi-row solvent outer tube is adopted to fully simulate each part of the stomach and the intestinal tract, the multi-row solvent outer tube can simulate the PH environments of various different parts, the inner tube is moved upwards when the environment is changed for medicines, and the next row of solvent outer tube is moved, so that the solvent outer tube does not need to be replaced manually, the experiment time is not delayed, and the inaccuracy of experimental data is avoided.
4. The special design prevents evaporating lid, leads to the solvent evaporation in the solvent outer tube oozes for a long time experiment, and experimental data error is big, is unfavorable for the condition of going on of experiment, has designed the toper and has prevented evaporating lid, simple structure, reasonable in design, and the rim of a cup card of solvent cup is gone into and is sealed the inslot, and sealed effect is splendid, and solvent in the solvent cup evaporates the back, can condense in the lower extreme of inner seal post to drip back in the solvent, reduced the solvent loss, guaranteed experimental data's accuracy.
Drawings
Fig. 1 is a front view of the present invention.
Fig. 2 is a perspective view of the present invention.
Fig. 3 is a bottom perspective view of the present invention.
FIG. 4 is a top view of the solvent outer tube placement plate of the present invention.
FIG. 5 is a schematic cross-sectional view of a solvent outer tube placed on a solvent outer tube placement plate according to the present invention.
Fig. 6 is a schematic view of the tablet capsule inner tube placed within the solvent outer tube.
FIG. 7 is a schematic view of the section of the inner tube A-A of the tablet capsule.
Fig. 8 is a schematic view of the first patch inner tube placed within the solvent outer tube.
Fig. 9 is a schematic view of the placement of the second patch inner tube within the solvent outer tube.
Fig. 10 is an enlarged schematic view of the bottom of the inner tube of the second patch.
Fig. 11 is a schematic view of the placement of the inner tube of a cardiac stent within the outer tube of solvent.
Fig. 12 is a bottom view of an inner tube of a cardiac stent.
Fig. 13 is a schematic view of the inner tube of the plaster placed inside the outer tube of the solvent.
Fig. 14 is a schematic view of a tapered evaporation resistant cap.
Fig. 15 is a cross-sectional view of a tapered evaporation prevention cap.
List of reference numerals:
a base 1, a bottom plate 101 and a side plate 102;
a water tank 2;
the vertical moving mechanism 3, the connecting frame 31, the vertical fixing column 32, the vertical linear module 33 and the horizontal linear module sliding block 34;
a horizontal moving mechanism 4, a horizontal linear module 41, a horizontal linear module slider 42, a support column 43, a bottom sliding mechanism 44, a bottom support plate 45, a bottom sliding column 46, a bottom sliding block 47, a bottom connecting plate 48, and a side connecting plate 49;
a controller 5, a display 6,
A sampling bracket 7, a bottom fixing column 71 and a placing plate 72;
an inner tube mount 8, a vertical plate 81, a horizontal plate 82, and a mount plate 83;
an inner tube 9, a connecting rod 12,
A solvent outer tube 10,
The solvent outer tube placing plate 11, the solvent outer tube placing through hole 111, the U-shaped connecting plate 112 and the through hole 113;
a solvent outer tube supporting plate 13 and a fixing boss 131;
an elastic cover body 141, an outer envelope 142, an inner sealing column 143, a sealing groove 144 and a sealing groove 145 of the conical anti-evaporation cover;
tablet capsule inner tube 16, inner tube body 161, cover 162, filter screen 163, waist-shaped hole 164;
a first patch inner tube 17, a circular inner bore 171;
a second patch inner tube 18, an annular groove 181, an elastic ring 182;
a heart stent inner tube 19, an upper plate 191, a lower ring 192, a bottom cover 193, a middle post 194, a circular through hole 195;
an inner plaster tube 20, a bottom plate 201 and a metal spring 202.
Detailed Description
In order to make the technical scheme of the invention clearer and more definite, the invention is further described below with reference to the accompanying drawings, and any scheme obtained by carrying out equivalent substitution and conventional reasoning on the technical characteristics of the technical scheme of the invention falls into the protection scope of the invention. The fixing arrangement and fixing structure of the fixing connection mentioned in this embodiment are all known techniques known to those skilled in the art, such as welding, screw connection, bolt-nut connection, riveting, etc. In this embodiment, the controller is a PLC controller, and the PLC controller controls the movement of the vertical movement mechanism and the horizontal movement mechanism through software programming. In this embodiment, the controller is a PLC controller, and the PLC controller controls the movement of the vertical movement mechanism and the horizontal movement mechanism through software programming. The programming method and the PLC are customized for software companies, and are not related to the key point of the patent, and are not described in detail herein. The display screen is obtained by direct purchase on the market.
Referring to the drawings, the high-efficiency automatic release rate sampling system is characterized by comprising a base, a water tank, a vertical moving mechanism, a horizontal moving mechanism, a controller, a display, a sampling bracket, an inner pipe placing frame, an inner pipe, an outer solvent pipe and an outer solvent pipe placing plate;
the base is used for installing the water tank, the horizontal moving mechanism and the vertical moving mechanism; the base comprises a bottom plate and two side plates, the two side plates are vertically and symmetrically distributed and fixed on two sides of the bottom plate, and the water tank is fixedly arranged between the two side plates; the water tank is internally provided with water, and the top of the water tank is of an opening structure;
the controller is electrically connected with the display, the vertical moving mechanism and the horizontal moving mechanism through cables, and is used for controlling the vertical moving mechanism and the horizontal moving mechanism to move, and the display is used for displaying controller signals;
the horizontal moving mechanism comprises a horizontal linear module, a side connecting plate and a bottom sliding mechanism; the horizontal linear modules are arranged horizontally, the number of the horizontal linear modules is two, the horizontal linear modules are arranged on two base side plates, support columns are fixedly arranged at two ends of each side plate of the base, and the two ends of each horizontal linear module are respectively fixed on the support columns; the horizontal linear module is provided with a sliding block, one side of the sliding block on the horizontal linear module is fixedly connected with the side connecting plate, the number of the side connecting plates is two, the two side connecting plates are fixedly connected with the sliding blocks of the two horizontal linear modules respectively, and one side connecting plate is fixedly connected with the display and the controller;
the bottom sliding mechanism comprises two bottom supporting plates, three bottom sliding columns, three bottom sliding blocks and a bottom connecting plate; the number of the bottom support plates is two, and the bottom support plates are vertically arranged at two ends of the bottom of the base bottom plate; the bottom sliding column is of a cylindrical structure, two ends of the bottom sliding column are fixedly connected to the two bottom supporting plates, through holes are formed in the bottom sliding blocks, the bottom sliding blocks penetrate through the bottom sliding column through the through holes to realize sliding connection on the bottom sliding column, the bottom connecting plate is of a strip-shaped plate body structure, two ends of the bottom connecting plate are fixedly connected with bottoms of the two side connecting plates, and three bottom sliding blocks are fixedly connected with the bottom connecting plate;
the vertical moving mechanism comprises a connecting frame, a vertical fixing column and a vertical linear module; the connecting frame is of a square plate body structure, two sides of the connecting frame are respectively and fixedly connected with two sides of the top of the side connecting plate, the number of the vertical fixing columns is one, the connecting frame is of a square column body structure, and the vertical fixing columns are vertically arranged in the middle position of the top of the connecting frame; the vertical linear modules are linear modules, the number of the linear modules is one, and the linear modules are vertically arranged on one side of the vertical fixing column; the sliding block is arranged on the vertical linear module, and the sliding block of the vertical linear module is fixedly connected with the inner tube placing frame;
the inner tube placing frame comprises a vertical plate, a horizontal plate and a placing plate; the vertical plate is vertically arranged, one side of the top is fixedly connected with a sliding block of the vertical linear module, the other side of the bottom is fixedly connected with a horizontal plate, a plurality of inner tube mounting through holes which are vertically arranged are formed in the mounting plate, the inner tube mounting through holes are used for mounting inner tubes, a connecting rod is arranged at the top of each inner tube, passes through the inner tube mounting through holes, and is fixed on the mounting plate through bolts and nuts, and the central position of one side of the mounting plate is fixedly connected with the horizontal plate;
the sampling support is arranged on one side of the connecting frame, the sampling support is of an integrated structure and comprises a bottom fixing column and a placing plate, the placing plate is horizontally arranged, a plurality of round holes are formed in the placing plate and used for placing sampling pipes, the bottom fixing column is of an inclined structure, the top of the bottom fixing column is fixedly connected with one side of the placing plate, and the bottom of the bottom fixing column is fixedly connected with the top of the connecting frame;
the solvent outer tube is placed in the water tank, the top ends of the two supporting columns on one base side are fixedly connected with a solvent outer tube supporting plate, 6 groups of fixing protrusion groups are fixedly arranged on each solvent outer tube supporting plate, and each fixing protrusion group comprises two fixing protrusions;
the solvent outer tube placing plates are of long-strip-shaped structures, the number of the solvent outer tube placing plates is a plurality of the solvent outer tube placing plates is an integral structure, a plurality of solvent outer tube placing through holes are uniformly formed in the solvent outer tube placing plates, and the solvent outer tubes are fixed on the solvent outer tube placing plates through the solvent outer tube placing through holes; two ends of the solvent outer tube placing plate are provided with a U-shaped connecting plate, one side of the U-shaped connecting plate is fixedly connected with the solvent outer tube placing plate, the two U-shaped connecting plates are symmetrically distributed at two ends of the solvent outer tube placing plate, the top and the bottom of the U-shaped connecting plate are respectively provided with two through holes, and the positions of the through holes on the U-shaped connecting plate correspond to the positions of the fixing protrusions; the solvent outer tube placing plate is embedded into the through hole on the U-shaped connecting plate through the fixing protrusion to be detachably fixed with the base;
the solvent outer tube placing plate is placed above the water tank, and the solvent outer tube is arranged inside the water tank through the solvent outer tube placing plate.
Further, the inner tube is one of a tablet capsule inner tube, a first patch inner tube, a second patch inner tube, a heart support inner tube and a plaster inner tube.
Further, the tablet capsule inner tube comprises an inner tube body and a cover, the inner tube body is a hollow tube body, external threads are arranged at the bottom of the inner tube body, the shape and the size of the cover correspond to those of the bottom of the inner tube body, internal threads are arranged on the inner side of the cover, the cover is detachably connected with the external threads through matching of the internal threads, and a filter screen is arranged at the center of the bottom of the cover; the connecting pipe connected to the tablet capsule inner pipe is of a hollow structure, a waist-shaped hole is formed in one side of the bottom of the connecting pipe, sampling is needed when the tablet capsule inner pipe is used, and a sampling hose is inserted into the waist-shaped hole, so that a medicine collecting hose stretches into the tablet capsule to carry out a walking line.
Further, the first patch inner tube is of a circular cylinder structure, and a circular inner hole is formed in the first patch inner tube.
Further, the second patch inner tube is of a circular cylinder structure, an annular groove is formed in the outer surface of the second patch inner tube, and an elastic ring is arranged in the annular groove.
Further, heart support inner tube includes upper plate, lower ring, bottom and spliced pole, the upper plate is circular plate body structure, the lower ring is ring shape structure, upper plate and lower ring size, shape are corresponding, the upper plate corresponds the setting from top to bottom with lower ring, spliced pole quantity is a plurality of, spliced pole top and upper plate fixed connection, bottom and lower ring fixed connection, the spliced pole is circular evenly distributed between upper column and lower ring, lower ring bottom periphery is provided with the external screw thread, the bottom is circular lid structure, be provided with the internal thread on the inboard all around of bottom, realize dismantling through internal and external screw thread cooperation between lower ring and the bottom and be connected, be provided with a plurality of circular through-holes on the bottom.
Further, the plaster inner tube comprises a bottom plate and a metal spring, one side of the top of the metal spring is fixedly connected with the connecting column, and the bottom surface of the bottom of the metal spring is fixedly connected with the bottom plate.
Further, a conical anti-evaporation cover is arranged on the solvent outer tube and comprises an elastic cover body made of rubber, the elastic cover body comprises an outer jacket and an inner sealing column, and a sealing groove is arranged between the outer jacket and the inner sealing column; the outer envelope and the inner envelope column are of an integrated structure, the outer envelope is in a circular tube shape, the cross section of the outer envelope is in a circular ring shape, the inner Feng Zhu is in a cylinder shape, and the lower end of the cylinder shape is in a conical shape; the sealing groove is positioned between the outer envelope and the inner sealing column, the cross section of the sealing groove is circular, the upper end of the sealing groove is provided with a sealing groove, the sealing groove is circular, and the longitudinal section of the sealing groove is omega-shaped.
Further, the number of the solvent outer tube placing plates is the same as the number of the fixing protrusion groups.
Further, the side connecting plates are of trapezoid structures.
Further, the fixing protrusion is of an integrated structure, the bottom of the fixing protrusion is a cylinder, and the top of the fixing protrusion is of a hemispherical structure.
The patent application working flow of the invention is as follows:
1. and (3) preparing the corresponding inner tube for medicament, wherein all accessories are in a usable state.
2. The controller is started, the inner tube reaches the first row through the horizontal moving mechanism, the first row of evaporation preventing covers are opened, and the inner tube descends into the solvent outer tube through the vertical moving mechanism (the solvent is already put into the solvent outer tube).
3. The inner tube is static in the solvent outer tube for a period of time (range: 1-5 min) to adapt to the current solvent.
4. Moves up and down according to a set speed (the lifting speed range is 4-50 times/min plus or minus 0.5 times/min).
5. After the set time (0-99 h99min99 s) is reached, the inner tube is raised to the set point (0-100 mm), and is stationary for a period of time (range: 1-10 min), and the solvent in the inner tube is dropped into the outer tube.
6. Reaching the next row, and repeating the experimental process of 2-5;
7. after all 6 rows are finished, the movement can be continued from the second row, and 20 samples can be taken at most.
The beneficial effects of the invention are as follows:
1. the tablet capsule inner tube, the first patch inner tube, the second patch inner tube, the heart support inner tube and the plaster inner tube can be applied to a reciprocating cylinder method and a reciprocating support method, can be used for simultaneously measuring medicines in two methods, and are rich in use methods;
when the reciprocating tube method is used for sampling the release rate of the tablet capsule, the drug tablet or the capsule drug to be tested is placed in the tablet capsule inner tube, if the tablet is smaller, a glass ball can be placed in the tablet capsule inner tube, and the drug tablet or the capsule drug is placed in the glass ball, so that the drug tablet or the capsule drug is fixed in the tablet capsule inner tube, and the test and detection are realized;
the reciprocating bracket method is used for sampling the release rate of plaster, external patch and heart bracket, when in use, the large-area external patch uses the first patch inner tube, the patch medicine surface is outwards, and the medicine-free surface is stuck on the outer wall of the first patch inner tube, so as to realize measurement; the small-area external patch uses a second patch inner tube, the patch medicine surface faces outwards, the medicine-free surface contacts with the outer wall of the second patch tube, and then the elastic ring is sleeved outside the patch and embedded in the annular groove, so that the external patch is fixed outside the second patch inner tube; the heart stent uses the heart stent inner tube, the heart stent is placed between the middle columns, and the bottom cover is screwed tightly; the thick topical plaster can be applied by placing the inner tube of the plaster.
2. The invention simulates intestinal peristalsis by adopting a mode of up-and-down movement, wherein the inner tube adopts a mode of up-and-down movement (the up-and-down movement amplitude of a reciprocating cylinder method is 10CM; the up-and-down movement amplitude of a reciprocating bracket method is 2 CM) on the outer tube of the solvent, the inner tube simulates the gastrointestinal environment in a human body, the inner tube moves up and down in the outer tube of the solvent, the dissolution force is strong, the inner tube is more suitable for the gastrointestinal peristalsis mode, and the up-and-down movement mode is used for simulating the gastrointestinal peristalsis environment, so that the experimental effect is good.
3. The multiple solvent outer tubes are adopted to fully simulate each part of the stomach and the intestinal tract, the multiple solvent outer tubes can simulate the PH environments of multiple different parts, the inner tube is moved upwards when the environment is changed for medicines, and the next row of solvent outer tubes is moved, so that the solvent outer tubes do not need to be replaced manually, the experimental time is not delayed, and the experimental data are prevented from being inaccurate.
4. The special design prevents evaporating lid, leads to the solvent evaporation in the solvent outer tube oozes for a long time experiment, and experimental data error is big, is unfavorable for the condition of going on of experiment, has designed the toper and has prevented evaporating lid, simple structure, reasonable in design, and the rim of a cup card of solvent cup is gone into and is sealed the inslot, and sealed effect is splendid, and solvent in the solvent cup evaporates the back, can condense in the lower extreme of inner seal post to drip back in the solvent, reduced the solvent loss, guaranteed experimental data's accuracy.
Claims (10)
1. The high-efficiency automatic release rate sampling system is characterized by comprising a base, a water tank, a vertical moving mechanism, a horizontal moving mechanism, a controller, a display, a sampling bracket, an inner tube placing frame, an inner tube, an outer solvent tube and an outer solvent tube placing plate;
the base is used for installing the water tank, the horizontal moving mechanism and the vertical moving mechanism; the base comprises a bottom plate and two side plates, the two side plates are vertically and symmetrically distributed and fixed on two sides of the bottom plate, and the water tank is fixedly arranged between the two side plates; the water tank is internally provided with water, and the top of the water tank is of an opening structure;
the controller is electrically connected with the display, the vertical moving mechanism and the horizontal moving mechanism through cables, and is used for controlling the vertical moving mechanism and the horizontal moving mechanism to move, and the display is used for displaying controller signals;
the horizontal moving mechanism comprises a horizontal linear module, a bottom sliding mechanism, a side connecting plate and a side fixing structure; the horizontal linear modules are arranged horizontally, the number of the horizontal linear modules is two, the horizontal linear modules are arranged on two base side plates, support columns are fixedly arranged at two ends of each side plate of the base, and the two ends of each horizontal linear module are respectively fixed on the support columns; the horizontal linear module is provided with a sliding block, one side of the sliding block on the horizontal linear module is fixedly connected with the side connecting plate, the number of the side connecting plates is two, the two side connecting plates are fixedly connected with the sliding blocks of the two horizontal linear modules respectively, and one side connecting plate is fixedly connected with the display and the controller;
the bottom sliding mechanism comprises two bottom supporting plates, three bottom sliding columns, three bottom sliding blocks and a bottom connecting plate; the number of the bottom support plates is two, and the bottom support plates are vertically arranged at two ends of the bottom of the base bottom plate; the bottom sliding column is of a cylindrical structure, two ends of the bottom sliding column are fixedly connected to the two bottom supporting plates, through holes are formed in the bottom sliding blocks, the bottom sliding blocks penetrate through the bottom sliding column through the through holes to realize sliding connection on the bottom sliding column, the bottom connecting plate is of a strip-shaped plate body structure, two ends of the bottom connecting plate are fixedly connected with bottoms of the two side connecting plates, and three bottom sliding blocks are fixedly connected with the bottom connecting plate;
the vertical moving mechanism comprises a connecting frame, a vertical fixing column and a vertical linear module; the connecting frame is of a square plate body structure, two sides of the connecting frame are respectively and fixedly connected with two sides of the top of the side connecting plate, the number of the vertical fixing columns is one, the connecting frame is of a square column body structure, and the vertical fixing columns are vertically arranged in the middle position of the top of the connecting frame; the vertical linear modules are linear modules, the number of the linear modules is one, and the linear modules are vertically arranged on one side of the vertical fixing column; the sliding block is arranged on the vertical linear module, and the sliding block of the vertical linear module is fixedly connected with the inner tube placing frame;
the inner tube placing frame comprises a vertical plate, a horizontal plate and a placing plate; the vertical plate is vertically arranged, one side of the top is fixedly connected with a sliding block of the vertical linear module, the other side of the bottom is fixedly connected with a horizontal plate, a plurality of inner tube mounting through holes which are vertically arranged are formed in the mounting plate, the inner tube mounting through holes are used for mounting inner tubes, a connecting rod is arranged at the top of each inner tube, passes through the inner tube mounting through holes, and is fixed on the mounting plate through bolts and nuts, and the central position of one side of the mounting plate is fixedly connected with the horizontal plate;
the sampling support is arranged on one side of the connecting frame, the sampling support is of an integrated structure and comprises a bottom fixing column and a placing plate, the placing plate is horizontally arranged, a plurality of round holes are formed in the placing plate and used for placing sampling pipes, the bottom fixing column is of an inclined structure, the top of the bottom fixing column is fixedly connected with one side of the placing plate, and the bottom of the bottom fixing column is fixedly connected with the top of the connecting frame;
the solvent outer tube is placed in the water tank, the top ends of the two supporting columns on one base side are fixedly connected with a solvent outer tube supporting plate, a plurality of fixing protrusion groups are fixedly arranged on each solvent outer tube supporting plate, and each fixing protrusion group comprises two fixing protrusions;
the solvent outer tube placing plates are of long-strip-shaped structures, the number of the solvent outer tube placing plates is a plurality of the solvent outer tube placing plates is an integral structure, a plurality of solvent outer tube placing through holes are uniformly formed in the solvent outer tube placing plates, and the solvent outer tubes are fixed on the solvent outer tube placing plates through the solvent outer tube placing through holes; two ends of the solvent outer tube placing plate are provided with a U-shaped connecting plate, one side of the U-shaped connecting plate is fixedly connected with the solvent outer tube placing plate, the two U-shaped connecting plates are symmetrically distributed at two ends of the solvent outer tube placing plate, the top and the bottom of the U-shaped connecting plate are respectively provided with two through holes, and the positions of the through holes on the U-shaped connecting plate correspond to the positions of the fixing protrusions; the solvent outer tube placing plate is embedded into the through hole on the U-shaped connecting plate through the fixing protrusion to be detachably fixed with the base;
the solvent outer tube placing plate is placed above the water tank, and the solvent outer tube is arranged inside the water tank through the solvent outer tube placing plate.
2. The efficient automatic release rate sampling system of claim 1, wherein the inner tube is one of a tablet capsule inner tube, a first patch inner tube, a second patch inner tube, a heart stent inner tube, and a plaster inner tube.
3. The efficient automatic release rate sampling system according to claim 2, wherein the tablet capsule inner tube comprises an inner tube body and a cover, the inner tube body is a hollow tube body, external threads are arranged at the bottom of the inner tube body, the shape and the size of the cover correspond to those of the bottom of the inner tube body, internal threads are arranged on the inner side of the cover, the cover is detachably connected through the matching of the internal threads and the external threads, and a filter screen is arranged at the center of the bottom of the cover; the connecting pipe connected to the tablet capsule inner pipe is of a hollow structure, a waist-shaped hole is formed in one side of the bottom of the connecting pipe, sampling is needed when the tablet capsule inner pipe is used, and a sampling hose is inserted into the waist-shaped hole, so that a medicine collecting hose stretches into the tablet capsule to carry out a walking line.
4. The efficient automatic release rate sampling system of claim 2, wherein the first patch inner tube has a circular cylindrical configuration with a circular inner bore disposed therein.
5. The efficient automatic release rate sampling system of claim 2, wherein the second patch inner tube is of a circular cylindrical configuration, an annular groove is provided on an outer surface of the second patch inner tube, and an elastic ring is provided inside the annular groove.
6. The high-efficiency automatic release rate sampling system according to claim 2, wherein the heart stent inner tube comprises an upper plate, a lower ring, a bottom cover and a middle column, the upper plate is of a circular plate body structure, the lower ring is of a circular ring structure, the upper plate corresponds to the lower ring in size and shape, the upper plate and the lower ring are arranged correspondingly up and down, the middle column is a plurality of middle columns, the top of the middle column is fixedly connected with the upper plate, the bottom of the middle column is fixedly connected with the lower ring, the middle column is uniformly distributed in a circular shape between the upper column and the lower ring, external threads are arranged on the periphery of the bottom of the lower ring, the bottom cover is of a circular cover body structure, internal threads are arranged on the inner side of the periphery of the bottom cover, detachable connection is realized between the lower ring and the bottom cover through the matching of the internal threads and the external threads, and a plurality of circular through holes are arranged on the bottom cover.
7. The efficient automatic release rate sampling system of claim 2, wherein the plaster inner tube comprises a bottom plate and a metal spring, wherein one side of the top of the metal spring is fixedly connected with the connecting column, and the bottom surface of the metal spring is fixedly connected with the bottom plate.
8. The efficient automatic release rate sampling system according to claim 1, wherein the solvent outer tube is provided with a conical anti-evaporation cover, the conical anti-evaporation cover comprises an elastic cover body made of rubber, the elastic cover body comprises an outer jacket and an inner sealing column, and a sealing groove is arranged between the outer jacket and the inner sealing column; the outer envelope and the inner envelope column are of an integrated structure, the outer envelope is in a circular tube shape, the cross section of the outer envelope is in a circular ring shape, the inner Feng Zhu is in a cylinder shape, and the lower end of the cylinder shape is in a conical shape; the sealing groove is positioned between the outer envelope and the inner sealing column, the cross section of the sealing groove is circular, the upper end of the sealing groove is provided with a sealing groove, the sealing groove is circular, and the longitudinal section of the sealing groove is omega-shaped.
9. The efficient automatic release rate sampling system of claim 1, wherein the number of solvent tube placement plates is the same as the number of fixed lobe sets.
10. The efficient automatic release rate sampling system of claim 1, wherein the side webs are trapezoidal in configuration.
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| CN110045070A (en) * | 2019-04-03 | 2019-07-23 | 禄根仪器(镇江)有限公司 | A kind of molten cup cap-opening mechanism of automatic release rate sampling system |
| CN110045072B (en) * | 2019-04-19 | 2023-12-05 | 禄根仪器(镇江)有限公司 | Drug absorption system and absorption sampling method thereof |
| CN113009094B (en) * | 2021-02-03 | 2023-07-07 | 禄根仪器(镇江)有限公司 | Novel high-efficient medicine dissolves out appearance |
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