CN109298150B - Special efficient rack for automatic release rate sampling system - Google Patents
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- CN109298150B CN109298150B CN201811336864.5A CN201811336864A CN109298150B CN 109298150 B CN109298150 B CN 109298150B CN 201811336864 A CN201811336864 A CN 201811336864A CN 109298150 B CN109298150 B CN 109298150B
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Abstract
A special high-efficiency rack for an automatic release rate sampling system is characterized by comprising a base, a vertical moving mechanism, a horizontal moving mechanism, a sampling support, an inner tube placing rack and a solvent outer tube placing plate; the invention adopts the up-and-down motion mode to simulate the intestinal peristalsis, the inner tube adopts the up-and-down motion mode in the solvent outer tube, the solvent outer tube is used for simulating the gastrointestinal environment in the human body, the inner tube moves up and down in the solvent outer tube, the dissolution force is strong, on the other hand, the invention is more suitable for the gastrointestinal peristalsis mode, and the up-and-down motion mode is used for simulating the gastrointestinal peristalsis environment more appropriately, and the experimental effect is good.
Description
Technical Field
The invention belongs to the technical field of medical experimental equipment application, and particularly relates to a special high-efficiency rack for an automatic release rate sampling system.
Background
In order to produce a desired pharmacological effect, the drug must be made available in vivo at an appropriate concentration at its site of action. This effectiveness is affected by a number of factors, including: the amount of drug administered, the rate of drug absorption, partitioning (binding or localization) in the tissue, drug metabolism, and elimination from the body.
As a method for examining drug properties, dissolution examination plays an important role in the links of quality consistency evaluation and the like when a change occurs after the imitation and approval of a pharmaceutical preparation. The united states pharmacopoeia divides a drug dissolution and release device into 1-7 methods, wherein the third method is a reciprocating cylinder method and is used for determining dissolution of drug tablets and capsules; the seventh method is a reciprocating stent method, and is used for a dissolution measuring device of ointment, plaster patch and cardiac stent.
Most of devices for testing the drug release rate in the market at present are dissolution instruments, and in the actual use process, workers find that the devices have the following defects:
1. the existing dissolution instrument adopts the technical scheme that medicines are placed in a medicine basket, the medicine basket is placed in a solvent outer tube, the solvent outer tube is used for simulating the gastrointestinal environment inside a human body, the medicine basket rotates inside the solvent outer tube, and the rotation mode is used for simulating the gastrointestinal peristalsis of the human body. However, in the experiment, the drug basket is rotated to ensure that the dissolution force is insufficient, on the other hand, the gastrointestinal peristalsis is not rotational movement, the simulation of the gastrointestinal peristalsis environment by rotation is not proper, and the experiment effect is not good.
2. For orally administered drug dosage forms, drug absorption occurs in the gastrointestinal tract. During transit through the gastrointestinal tract, the drug should be released from the dosage form and available in solution at or near the desired site of absorption. The rate at which the drug is released from a dosage form and into solution is important to the kinetics of drug absorption. The dosage form and thus the drug are subjected to a change in pH during the passage, for example from about pH1.2 (during fasting-but after food consumption the pH of the stomach increases up to 4.0) to about 7.4 in the other parts of the digestive tract (bile pH: 7.0-7.4 and intestinal pH: 5 to 7). Other factors that affect drug absorption include the physicochemical properties of the drug substance itself, such as its pKa, solubility, crystallization energy, and specific surface area, as well as the characteristics of the gastrointestinal tract itself, such as the properties of luminal components (pH, surface tension, volume, agitation, and buffering capacity) and changes that occur upon ingestion of food.
Therefore, when carrying out the experiment of dissolving out, often will carry out abundant simulation to each position of stomach and intestinal, this process needs to use a plurality of even use multiple menstruum outer tubes to simulate the environment, and present appearance of dissolving out is when an experiment, mostly uses same kind of menstruum outer tube, need take out the medicine basket when trading the environment to the medicine, changes the menstruum outer tube again, so, can produce the error on the experimental time, causes the experimental data inaccurate easily.
Disclosure of Invention
In order to solve the existing problems, the invention discloses a special high-efficiency rack for an automatic release rate sampling system, which has the following specific technical scheme:
a special high-efficiency rack for an automatic release rate sampling system is characterized by comprising a base, a vertical moving mechanism, a horizontal moving mechanism, a sampling support, an inner tube placing rack and a solvent outer tube placing plate;
the base is used for mounting the horizontal moving mechanism, the vertical moving mechanism and a water tank of the sampling system; the base comprises a bottom plate and two side plates, the two side plates are vertically and symmetrically distributed and fixed on two sides of the bottom plate, and the water tank is installed and fixed between the two side plates; the top ends of two support columns on one side of the base are fixedly connected with a solvent outer tube support plate, each solvent outer tube support plate is fixedly provided with a plurality of groups of fixing bulges, and each group of fixing bulges comprises two fixing bulges;
the horizontal moving mechanism comprises a horizontal linear module, a bottom sliding mechanism, a side connecting plate and a side fixing structure; the horizontal linear modules are linear modules, the number of the horizontal linear modules is two, the horizontal linear modules are arranged on two base side plates, two ends of each base side plate are fixedly provided with supporting columns, the horizontal linear modules are arranged horizontally, and two ends of each horizontal linear module are respectively fixed on the supporting columns; the horizontal linear module is provided with a sliding block, one side of the sliding block on the horizontal linear module is fixedly connected with the side connecting plates, and the number of the side connecting plates is two, and the two side connecting plates are respectively and fixedly connected with the sliding blocks of the two horizontal linear modules;
the bottom sliding mechanism comprises two bottom supporting plates, three bottom sliding columns, three bottom sliding blocks and a bottom connecting plate; the number of the bottom supporting plates is two, and the bottom supporting plates are vertically arranged at two ends of the bottom of the base bottom plate; the bottom sliding column is of a cylindrical structure, two ends of the bottom sliding column are fixedly connected to the two bottom supporting plates, a through hole is formed in the bottom sliding block, the bottom sliding block penetrates through the bottom sliding column through the through hole to be in sliding connection on the bottom sliding column, the bottom connecting plate is of a long strip-shaped plate structure, two ends of the bottom connecting plate are fixedly connected with the bottoms of the two side connecting plates, and the three bottom sliding blocks are fixedly connected to the bottom connecting plate;
the vertical moving mechanism comprises a connecting frame, a vertical fixing column and a vertical linear module; the connecting frame is of a square plate body structure, two sides of the connecting frame are fixedly connected with two sides of the top of the side connecting plate respectively, the number of the vertical fixing columns is one, the connecting frame is of a square column body structure, and the vertical fixing columns are vertically arranged in the middle of the top of the connecting frame; the vertical straight line modules are linear modules, the number of the vertical straight line modules is one, and the vertical straight line modules are vertically arranged on one side of the vertical fixed column; the vertical linear module is provided with a sliding block, and the sliding block of the vertical linear module is fixedly connected with the inner pipe placing frame;
the inner pipe placing frame comprises a vertical plate, a horizontal plate and a placing plate; the vertical plate is vertically arranged, one side of the top of the vertical plate is fixedly connected with a sliding block of the vertical linear module, the other side of the bottom of the vertical plate is fixedly connected with a horizontal plate, the placing plate is provided with a plurality of vertically arranged inner tube placing through holes, the inner tube placing through holes are used for placing sampling inner tubes, the top of each sampling inner tube is provided with a connecting rod, the connecting rod penetrates through the inner tube placing through holes, the connecting rod is fixed on the placing plate through bolts and nuts, and the central position of one side of the placing plate is fixedly connected with the;
the sampling support is arranged on one side of the connecting frame, is of an integrated structure and comprises a bottom fixing column and a placing plate, the placing plate is horizontally arranged, a plurality of round holes are formed in the placing plate and used for placing sampling tubes, the bottom fixing column is of an inclined structure, the top of the bottom fixing column is fixedly connected with one side of the placing plate, and the bottom of the bottom fixing column is fixedly connected with the top of the connecting frame;
the solvent outer tube placing plates are of a long strip-shaped structure, the number of the solvent outer tube placing plates is a plurality of, the solvent outer tube placing plates are of an integrated structure, a plurality of solvent outer tube placing through holes are uniformly formed in the solvent outer tube placing plates, and the solvent outer tubes are fixed on the solvent outer tube placing plates through the solvent outer tube placing through holes in use; two ends of the solvent outer tube placing plate are provided with a U-shaped connecting plate, one side of the U-shaped connecting plate is fixedly connected with the solvent outer tube placing plate, the two U-shaped connecting plates are symmetrically distributed at the two ends of the solvent outer tube placing plate, the top and the bottom of each U-shaped connecting plate are provided with two through holes, and the positions of the through holes on the U-shaped connecting plates correspond to the positions of the fixing bulges; the solvent outer tube placing plate is detachably fixed with the base through the inner part of the through hole embedded on the U-shaped connecting plate by the fixing protrusion.
Furthermore, the number of the solvent outer tube placing plates is the same as that of the fixing protrusion groups.
Furthermore, the side connecting plate is of a trapezoidal structure.
Furthermore, the fixing bulge is of an integrated structure, the bottom of the fixing bulge is a cylinder, and the top of the fixing bulge is of a hemispherical structure.
The invention has the beneficial effects that:
1. the invention adopts the up-and-down motion mode to simulate the intestinal peristalsis, the inner tube adopts the up-and-down motion mode in the solvent outer tube, the solvent outer tube is used for simulating the gastrointestinal environment in the human body, the inner tube moves up and down in the solvent outer tube, the dissolution force is strong, on the other hand, the invention is more suitable for the gastrointestinal peristalsis mode, and the up-and-down motion mode is used for simulating the gastrointestinal peristalsis environment more appropriately, and the experimental effect is good.
2. Adopt multirow menstruum outer tube to carry out abundant simulation to each position of stomach and intestinal, multiple menstruum outer tube can simulate multiple different position PH degree environment, shifts up the inner tube when trading the environment to the medicine, moves to next row of menstruum outer tube can, does not need artificial change menstruum outer tube again, so, can not delay the experimental time, avoids causing the experimental data inaccurate.
Drawings
Fig. 1 is a front view of the present invention.
Fig. 2 is a perspective view of the present invention.
Fig. 3 is a bottom perspective view of the present invention.
FIG. 4 is a top view of the plate for placing the outer tube of the solvent according to the present invention.
FIG. 5 is a schematic cross-sectional view of a vehicle outer tube placed on a vehicle outer tube placing plate according to the present invention.
List of reference numerals:
a base 1, a bottom plate 101 and side plates 102;
the vertical moving mechanism 3, the connecting frame 31, the vertical fixing column 32, the vertical linear module 33 and the vertical linear module sliding block 34;
the horizontal moving mechanism 4, the horizontal linear module 41, the horizontal linear module slide block 42, the support column 43, the bottom sliding mechanism 44, the bottom support plate 45, the bottom sliding column 46, the bottom sliding block 47, the bottom connecting plate 48 and the side connecting plate 49;
the sampling support 7, the bottom fixing column 71 and the placing plate 72;
the inner pipe placing frame 8, a vertical plate 81, a horizontal plate 82 and a placing plate 83;
an inner tube 9, a connecting rod 12,
A solvent outer tube 10,
A solvent outer tube placing plate 11, a solvent outer tube placing through hole 111, a U-shaped connecting plate 112 and a through hole 113;
a solvent outer tube support plate 13 and a fixing projection 131.
Detailed Description
In order to make the technical scheme of the invention clearer and clearer, the invention is further described with reference to the accompanying drawings, and any scheme obtained by carrying out equivalent replacement and conventional reasoning on the technical characteristics of the technical scheme of the invention falls into the protection scope of the invention. The fixed connection, the fixed arrangement and the fixed structure mentioned in the embodiment are all known technologies known to those skilled in the art, such as welding, screw connection, bolt-nut connection, riveting and the like.
Examples
The special high-efficiency rack for the automatic release rate sampling system is characterized by comprising a base, a vertical moving mechanism, a horizontal moving mechanism, a sampling support, an inner tube placing rack and a solvent outer tube placing plate;
the base is used for mounting the horizontal moving mechanism, the vertical moving mechanism and a water tank of the sampling system; the base comprises a bottom plate and two side plates, the two side plates are vertically and symmetrically distributed and fixed on two sides of the bottom plate, and the water tank is installed and fixed between the two side plates; the top ends of two support columns on one side of the base are fixedly connected with a solvent outer tube support plate, each solvent outer tube support plate is fixedly provided with a plurality of groups of fixing bulges, and each group of fixing bulges comprises two fixing bulges;
the horizontal moving mechanism comprises a horizontal linear module, a bottom sliding mechanism, a side connecting plate and a side fixing structure; the horizontal linear modules are linear modules, the number of the horizontal linear modules is two, the horizontal linear modules are arranged on two base side plates, two ends of each base side plate are fixedly provided with supporting columns, the horizontal linear modules are arranged horizontally, and two ends of each horizontal linear module are respectively fixed on the supporting columns; the horizontal linear module is provided with a sliding block, one side of the sliding block on the horizontal linear module is fixedly connected with the side connecting plates, and the number of the side connecting plates is two, and the two side connecting plates are respectively and fixedly connected with the sliding blocks of the two horizontal linear modules;
the bottom sliding mechanism comprises two bottom supporting plates, three bottom sliding columns, three bottom sliding blocks and a bottom connecting plate; the number of the bottom supporting plates is two, and the bottom supporting plates are vertically arranged at two ends of the bottom of the base bottom plate; the bottom sliding column is of a cylindrical structure, two ends of the bottom sliding column are fixedly connected to the two bottom supporting plates, a through hole is formed in the bottom sliding block, the bottom sliding block penetrates through the bottom sliding column through the through hole to be in sliding connection on the bottom sliding column, the bottom connecting plate is of a long strip-shaped plate structure, two ends of the bottom connecting plate are fixedly connected with the bottoms of the two side connecting plates, and the three bottom sliding blocks are fixedly connected to the bottom connecting plate;
the vertical moving mechanism comprises a connecting frame, a vertical fixing column and a vertical linear module; the connecting frame is of a square plate body structure, two sides of the connecting frame are fixedly connected with two sides of the top of the side connecting plate respectively, the number of the vertical fixing columns is one, the connecting frame is of a square column body structure, and the vertical fixing columns are vertically arranged in the middle of the top of the connecting frame; the vertical straight line modules are linear modules, the number of the vertical straight line modules is one, and the vertical straight line modules are vertically arranged on one side of the vertical fixed column; the vertical linear module is provided with a sliding block, and the sliding block of the vertical linear module is fixedly connected with the inner pipe placing frame;
the inner pipe placing frame comprises a vertical plate, a horizontal plate and a placing plate; the vertical plate is vertically arranged, one side of the top of the vertical plate is fixedly connected with a sliding block of the vertical linear module, the other side of the bottom of the vertical plate is fixedly connected with a horizontal plate, the placing plate is provided with a plurality of vertically arranged inner tube placing through holes, the inner tube placing through holes are used for placing sampling inner tubes, the top of each sampling inner tube is provided with a connecting rod, the connecting rod penetrates through the inner tube placing through holes, the connecting rod is fixed on the placing plate through bolts and nuts, and the central position of one side of the placing plate is fixedly connected with the;
the sampling support is arranged on one side of the connecting frame, is of an integrated structure and comprises a bottom fixing column and a placing plate, the placing plate is horizontally arranged, a plurality of round holes are formed in the placing plate and used for placing sampling tubes, the bottom fixing column is of an inclined structure, the top of the bottom fixing column is fixedly connected with one side of the placing plate, and the bottom of the bottom fixing column is fixedly connected with the top of the connecting frame;
the solvent outer tube placing plates are of a long strip-shaped structure, the number of the solvent outer tube placing plates is a plurality of, the solvent outer tube placing plates are of an integrated structure, a plurality of solvent outer tube placing through holes are uniformly formed in the solvent outer tube placing plates, and the solvent outer tubes are fixed on the solvent outer tube placing plates through the solvent outer tube placing through holes in use; two ends of the solvent outer tube placing plate are provided with a U-shaped connecting plate, one side of the U-shaped connecting plate is fixedly connected with the solvent outer tube placing plate, the two U-shaped connecting plates are symmetrically distributed at the two ends of the solvent outer tube placing plate, the top and the bottom of each U-shaped connecting plate are provided with two through holes, and the positions of the through holes on the U-shaped connecting plates correspond to the positions of the fixing bulges; the solvent outer tube placing plate is detachably fixed with the base through the inner part of the through hole embedded on the U-shaped connecting plate by the fixing protrusion.
Furthermore, the number of the solvent outer tube placing plates is the same as that of the fixing protrusion groups.
Furthermore, the side connecting plate is of a trapezoidal structure.
Furthermore, the fixing bulge is of an integrated structure, the bottom of the fixing bulge is a cylinder, and the top of the fixing bulge is of a hemispherical structure.
The invention has the beneficial effects that:
1. the invention adopts the up-and-down motion mode to simulate the intestinal peristalsis, the inner tube adopts the up-and-down motion mode in the solvent outer tube, the solvent outer tube is used for simulating the gastrointestinal environment in the human body, the inner tube moves up and down in the solvent outer tube, the dissolution force is strong, on the other hand, the invention is more suitable for the gastrointestinal peristalsis mode, and the up-and-down motion mode is used for simulating the gastrointestinal peristalsis environment more appropriately, and the experimental effect is good.
2. Adopt multirow menstruum outer tube to carry out abundant simulation to each position of stomach and intestinal, multiple menstruum outer tube can simulate multiple different position PH degree environment, shifts up the inner tube when trading the environment to the medicine, moves to next row of menstruum outer tube can, does not need artificial change menstruum outer tube again, so, can not delay the experimental time, avoids causing the experimental data inaccurate.
Claims (4)
1. A special high-efficiency rack for an automatic release rate sampling system is characterized by comprising a base, a vertical moving mechanism, a horizontal moving mechanism, a sampling support, an inner tube placing rack and a solvent outer tube placing plate;
the base is used for mounting the horizontal moving mechanism, the vertical moving mechanism and a water tank of the sampling system; the base comprises a bottom plate and two side plates, the two side plates are vertically and symmetrically distributed and fixed on two sides of the bottom plate, and the water tank is installed and fixed between the two side plates; the top ends of two support columns on one side of the base are fixedly connected with a solvent outer tube support plate, each solvent outer tube support plate is fixedly provided with a plurality of groups of fixing bulges, and each group of fixing bulges comprises two fixing bulges;
the horizontal moving mechanism comprises a horizontal linear module, a bottom sliding mechanism, a side connecting plate and a side fixing structure; the horizontal linear modules are linear modules, the number of the horizontal linear modules is two, the horizontal linear modules are arranged on two base side plates, two ends of each base side plate are fixedly provided with supporting columns, the horizontal linear modules are arranged horizontally, and two ends of each horizontal linear module are respectively fixed on the supporting columns; the horizontal linear module is provided with a sliding block, one side of the sliding block on the horizontal linear module is fixedly connected with the side connecting plates, and the number of the side connecting plates is two, and the two side connecting plates are respectively and fixedly connected with the sliding blocks of the two horizontal linear modules;
the bottom sliding mechanism comprises two bottom supporting plates, three bottom sliding columns, three bottom sliding blocks and a bottom connecting plate; the number of the bottom supporting plates is two, and the bottom supporting plates are vertically arranged at two ends of the bottom of the base bottom plate; the bottom sliding column is of a cylindrical structure, two ends of the bottom sliding column are fixedly connected to the two bottom supporting plates, a through hole is formed in the bottom sliding block, the bottom sliding block penetrates through the bottom sliding column through the through hole to be in sliding connection on the bottom sliding column, the bottom connecting plate is of a long strip-shaped plate structure, two ends of the bottom connecting plate are fixedly connected with the bottoms of the two side connecting plates, and the three bottom sliding blocks are fixedly connected to the bottom connecting plate;
the vertical moving mechanism comprises a connecting frame, a vertical fixing column and a vertical linear module; the connecting frame is of a square plate body structure, two sides of the connecting frame are fixedly connected with two sides of the top of the side connecting plate respectively, the number of the vertical fixing columns is one, the connecting frame is of a square column body structure, and the vertical fixing columns are vertically arranged in the middle of the top of the connecting frame; the vertical straight line modules are linear modules, the number of the vertical straight line modules is one, and the vertical straight line modules are vertically arranged on one side of the vertical fixed column; the vertical linear module is provided with a sliding block, and the sliding block of the vertical linear module is fixedly connected with the inner pipe placing frame;
the inner pipe placing frame comprises a vertical plate, a horizontal plate and a placing plate; the vertical plate is vertically arranged, one side of the top of the vertical plate is fixedly connected with a sliding block of the vertical linear module, the other side of the bottom of the vertical plate is fixedly connected with a horizontal plate, the placing plate is provided with a plurality of vertically arranged inner tube placing through holes, the inner tube placing through holes are used for placing sampling inner tubes, the top of each sampling inner tube is provided with a connecting rod, the connecting rod penetrates through the inner tube placing through holes, the connecting rod is fixed on the placing plate through bolts and nuts, and the central position of one side of the placing plate is fixedly connected with the;
the sampling support is arranged on one side of the connecting frame, is of an integrated structure and comprises a bottom fixing column and a placing plate, the placing plate is horizontally arranged, a plurality of round holes are formed in the placing plate and used for placing sampling tubes, the bottom fixing column is of an inclined structure, the top of the bottom fixing column is fixedly connected with one side of the placing plate, and the bottom of the bottom fixing column is fixedly connected with the top of the connecting frame;
the solvent outer tube placing plates are of a long strip-shaped structure, the number of the solvent outer tube placing plates is a plurality of, the solvent outer tube placing plates are of an integrated structure, a plurality of solvent outer tube placing through holes are uniformly formed in the solvent outer tube placing plates, and the solvent outer tubes are fixed on the solvent outer tube placing plates through the solvent outer tube placing through holes in use; two ends of the solvent outer tube placing plate are provided with a U-shaped connecting plate, one side of the U-shaped connecting plate is fixedly connected with the solvent outer tube placing plate, the two U-shaped connecting plates are symmetrically distributed at the two ends of the solvent outer tube placing plate, the top and the bottom of each U-shaped connecting plate are provided with two through holes, and the positions of the through holes on the U-shaped connecting plates correspond to the positions of the fixing bulges; the solvent outer tube placing plate is detachably fixed with the base through the inner part of the through hole embedded on the U-shaped connecting plate by the fixing protrusion.
2. The special efficient rack for the automatic release rate sampling system according to claim 1, wherein the number of the placing plates of the solvent outer tube is the same as that of the fixing protrusion sets.
3. The high efficiency rack of claim 1, wherein the side connection plates are trapezoidal in configuration.
4. The special high-efficiency rack for the automatic release rate sampling system as claimed in claim 1, wherein the fixing protrusion is of an integral structure, the bottom of the fixing protrusion is a cylinder, and the top of the fixing protrusion is of a hemisphere structure.
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| CN2069110U (en) * | 1990-07-06 | 1991-01-09 | 天津大学 | Automatic sampling apparatus for digestion medical solution |
| CN2583679Y (en) * | 2002-12-09 | 2003-10-29 | 赵学敏 | Bionic type biochemical reaction experimental apparatus |
| CN102313795B (en) * | 2011-07-28 | 2014-11-12 | 广东医学院 | Intelligent numerical control bionic drug dissolubility tester |
| CN203238267U (en) * | 2013-01-15 | 2013-10-16 | 北京金麦格生物技术有限公司 | Bioactive substance extractor |
| CN205434508U (en) * | 2016-02-24 | 2016-08-10 | 青岛普瑞森医药科技有限公司 | Vein kettle and blood filter screen assembly device |
| CN107525901B (en) * | 2017-09-20 | 2023-06-27 | 湖南慧泽生物医药科技有限公司 | Differential dissolution instrument and method for detecting dissolution consistency of pharmaceutical preparation |
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