CN209596217U - A kind of implant coating device - Google Patents
A kind of implant coating device Download PDFInfo
- Publication number
- CN209596217U CN209596217U CN201821358213.1U CN201821358213U CN209596217U CN 209596217 U CN209596217 U CN 209596217U CN 201821358213 U CN201821358213 U CN 201821358213U CN 209596217 U CN209596217 U CN 209596217U
- Authority
- CN
- China
- Prior art keywords
- tablet
- pipeline
- coating
- tablet pipeline
- push rod
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
The utility model provides a kind of implant coating device, including arranging machine, sheet pushing machine, coating pond, tablet pipeline, medicine-tablet conveying device, collection device, automatic control device；The arranging machine is connect with the sheet pushing machine, and the coating pond is circular arc type；The coating pond is provided with coating liquid；The entrance of the tablet pipeline is connect with the sheet pushing machine, the outlet of the tablet pipeline is connect with the collection device, the medicine-tablet conveying device is used to convey the implant tablet in tablet pipeline, the collection device is connect with automatic control device, and automatic control device is moved horizontally for controlling collection device.A kind of implant coating device structure provided by the utility model is simple, easy to operate, and the coating device of implant provided by the utility model is suitable for large-scale production.
Description
Technical field
The utility model relates to drug coating device more particularly to a kind of implant coating devices.
Background technique
In the research of sustained-release implant, the selection of biodegradable material is most important, and polylactic acid is a kind of with excellent
Good biocompatibility and degradable polymer, the final product being metabolized in vivo are water and carbon dioxide, intermediate product lactic acid
It is also internal normal sugar metabolism product, organ will not assembles again, be that FDA ratifies the medical accessory used.In order to guarantee drug
Compatibility prepares implant coating using the material same or similar with sustained-release matrix as far as possible, but polylactic acid
Viscosity is very big, and the implant stick to each other after coating destroys the yield rate of coating, is not suitable for being coated operation.In such as
State patent CN200610152903.7 discloses a kind of long-acting slow-release preparation of naltrexone, and it is micro- by naltrexone which employs polylactic acid
Ball is coated, and Chinese patent CN201110457641.6 discloses a kind of same DL- polylactic acid pair of long-acting naltrexone implant
Naltrexone microsphere after tabletting is coated.But as previously described, because polylactic acid viscosity is excessive, microballoon or tablet after coating
Between it is close or dry when contact when being placed in pallet with tray bottom surface can all cause coating membrane surfaces stick and rupture, influence medicine
The release stability of object.
Current research and open source literature technology, is the preparation process of laboratory level, can not be mass produced,
The condition of the numerous influence factors and acquisition of wherein investigating screening cannot be applicable in when being mass produced, this is because micro-
The active constituent of ball package is different, and the mode that external solution is added in interior phase emulsion is different, and the ingredient of solution is different, the tool of use
Body adjunct ingredient difference etc., will lead to its optimal preparation process condition have occurred it is difficult to predict variation, need again into
Row research, could obtain slow release effect and the ideal sustained-release micro-spheres of therapeutic effect.
A kind of a kind of Chinese invention patent (coating device of slow release fertilizer: 201810333180.3) coating of slow release fertilizer
Device includes support device and the film coating mechanism that is installed in support device；The film coating mechanism includes coating cylinder and is fixed on packet
The loading hopper of film cylinder upper end；The side inner surface of the coating cylinder is fixed with sieve, and the sieve connects with coating cylinder side wall
Place is provided with discharge chute mouth；The sidewall surfaces of the coating cylinder are provided with the circular through hole matched with sparge pipe, and the sparge pipe is logical
Cross the side wall that circular through hole runs through coating cylinder；The side inner surface of the coating cylinder is fixed with heating tube.Although the packet of the patent
Film device is simple, but carries out coating using sparge pipe in its patent, will cause that coating is imperfect and coating is non-uniform
Situation, and the thickness of packet that the slow release fertilizer after coating has, some packets it is thin, uniformity is poor, cause the uneven of sustained release performance,
So that cost increases.
Also the mode of useful sprinkling coating liquid carries out the technology of coating, such as Chinese patent literature in the prior art
CN107638295A discloses a kind of fluidized bed bottom spray coating device, and particle moves in the shape of a spiral in guide shell, passes through sprinkling
The mode of coating solution realizes particle envelope.But the completely inadaptable coated fertilizer with polylactic acid-based high viscosity of this method.
Utility model content
To solve problems of the prior art, the utility model provides a kind of implant coating device, structure letter
Single, easy to operate, the coating preparation of implant can only be carried out in the lab by avoiding original technology, can not be given birth on a large scale
It produces.
In order to solve the above technical problems, the technical solution adopted in the utility model is a kind of implant coating device, including
Arranging machine, sheet pushing machine, coating pond, tablet pipeline, medicine-tablet conveying device, collection device, automatic control system；The arranging machine with
The sheet pushing machine connection, the coating pond are circular arc type；The coating pond is provided with coating liquid；The entrance of the tablet pipeline with
The sheet pushing machine connection, the outlet of the tablet pipeline are connect with the collection device, and the medicine-tablet conveying device is for conveying
Implant tablet in tablet pipeline, the collection device are the anti-sticking special vessel of height.
Preferably, the material of the collection device is the stainless steel that surface has Teflon (polytetrafluoroethylene (PTFE)), described
Collection device is one piece of horizontal positioned plate, and the collection device is connect with automatic control device, and automatic control device is used for
Control collection device moves in the horizontal plane.
Preferably, tablet pipeline includes the first tablet pipeline, the second tablet pipeline, third tablet pipeline；First medicine
Piece pipeline, the second tablet pipeline, third tablet pipeline are hard tube, and the hard tube material is stainless steel tube, first tablet
Pipeline, the second tablet pipeline, third tablet pipeline are structure as a whole, the first tablet pipeline, the second tablet pipeline, third medicine
Piece pipeline is sequentially connected；
The entrance of the first tablet pipeline is connect with the sheet pushing machine, and the outlet of the third tablet pipeline is protruded into described
In collection device.
Preferably, the first tablet pipeline described in the utility model be arranged in parallel, the first tablet entrance with push away
The connection of piece machine, the first tablet pipe outlet are connect with the entrance of the second tablet pipeline；Second tablet pipeline is arc setting, fitting
In coating pond, third tablet pipeline is to be obliquely installed.
Preferably, the third tablet pipeline is obliquely installed, and tilt angle is 10-15 °.
Preferably, the second tablet pipeline bottom end is fitted on the inside of the coating pond, and the second tablet pipeline impregnates
In the coating liquid.
Preferably, the second tablet pipeline is equipped with mesh, and the mesh density is at least 100/30cm；The net
The diameter in hole is 2mm.
Preferably, the caliber of the second tablet pipeline is gradually reduced from entrance to outlet, the second tablet pipeline
Caliber inlet is 0.5-1.5mm bigger than exit, and the caliber of the second tablet pipe outlet is than the implant Tablet diameter
Big 1.5-2mm.
Preferably, the second tablet pipeline and the third tablet pipeline are respectively arranged with the first push rod track, second
Push rod track；The first push rod track and the second push rod track are the opening that width is 2mm.
The medicine-tablet conveying device includes first driving device, rotating push rod, the second driving device, translates push rod, described
Coating Chi Yuanxinweizhichu is provided with first driving device；The third tablet pipeline upper end is provided with the second driving device；Institute
First driving device is stated to be electrically connected with the automatic control device with second driving device；
Described rotating push rod one end is connect with the first driving device, and the other end is protruded into described by the first push rod track
Second tablet pipeline；
Described translation push rod one end is connect with second driving device, and the other end is protruded into described by the second push rod track
Third tablet pipeline.
Preferably, the rotating push rod, translation push rod are the steel that outside has Teflon, and the rotating push rod is put down
The diameter for moving push rod is 1.5mm.
Preferably, the coating liquid is PLA solution, and the concentration of the PLA solution is 5-9%.
Preferably, the implant tablet is 15-40s by the time of coating liquid in the second tablet pipeline；
Temperature of coating liquid during coating is controlled at 33-40 DEG C.
Treatment process of a kind of implant provided by the utility model in implant coating device: in the utility model
Implant tablet is discharged in arranging machine and enters sheet pushing machine, implant tablet is pushed into tablet pipeline by sheet pushing machine, implant tablet
Enter the second tablet pipeline along the first tablet pipeline, implant tablet is controlled second by first driving device and rotating push rod
Time in tablet pipeline is 15s-50s, preferably 30s, and coating process temperature controls between 33-40 DEG C, it is preferred that temperature is
37℃；After the completion of the coating in the second tablet pipeline, into third tablet pipeline, pass through the second driving device and translation push rod
Implant tablet is pushed into collection device and is collected.
It compares with the prior art, the beneficial effect that the utility model generates is:
(1) the utility model enables the biggish PLA of viscosity to be uniformly wrapped in implant surface by special coating device,
The imperfect problem of coating caused by adhesion from each other is effectively prevented, when overcoming that PLA is as coating liquid in the prior art
The incomplete problem of coating.
(2) coating device Chinese medicine tablet pipeline (especially the second tablet pipeline) provided by the utility model and implant tablet
Diameter it is most important, the caliber and implant Tablet diameter of the second tablet pipe outlet provided in the utility model difference
The consistency of implant tablet coating thickness can be effectively ensured in 1.5-2mm, avoid the occurrence of that envelope mass is irregular to ask
Topic.
(3) the utility model provides a kind of coating device of implant for the first time, and structure is simple, easy to operate, avoids
Original technology can only carry out the coating preparation of implant in the lab, can not be mass produced, the utility model provides
Implant coating device be suitable for large-scale production.
(4) caliber of the second tablet pipeline provided in the utility model is gradually reduced from entrance to outlet, it is ensured that coating
Integrality, and enable to the thickness of implant tablet uniform.
(5) the coating integrality, uniformity of coating device provided by the utility model, thickness and coating speed and second
The aperture of tablet pipeline, the concentration of coating liquid and elapsed time in coating liquid are related, joint effect between three,
Slow to avoid being coated, coating liquid is then easy endosmosis, destroys microballoon and skeleton；
(6) an a piece of packet, mutual adhesion, control time control may be implemented in the implant coating device provided in the utility model
Temperature guarantees that every implant tablet coating otherness very little, release test every release difference less than 3%.
(7) first driving device and rotating push rod provided in the utility model can control to exist per a piece of implant tablet
The immersion coating time in coating solution, so that the membrane wrapping thickness of every tablet of medicine is controlled, when implant tablet passes through coating liquid
Between be 30s when, membrane wrapping thickness is appropriate, and integrity degree is good.
(8) collection device in coating device provided by the utility model is the anti-sticking vessel of height, and material is surface
Steel with Teflon, and its collection device be it is transportable, can will not repeat to fall to avoid the implant tablet fallen
A spatial position, conglutinate between implant tablet is avoided.
Detailed description of the invention
Fig. 1 is the coating device structural schematic diagram of implant provided by the utility model；
Attached concrete meaning marked in the figure is as follows:
1: arranging machine；2: sheet pushing machine；3: coating pond；4: coating liquid；5: collection device；6: the first tablet pipelines；7: the second
Tablet pipeline；8: third tablet pipeline；9: first driving device；10: the second driving devices；11: rotating push rod；12: translation pushes away
Bar.
Specific embodiment
With reference to the accompanying drawing, specific embodiment of the present utility model is described in detail.
Join shown in Fig. 1, Fig. 1 is the coating device structural schematic diagram of implant provided by the utility model.
A kind of implant coating device, including arranging machine 1, sheet pushing machine 2, coating pond 3, tablet pipeline, medicine-tablet conveying device,
Collection device 5, automatic control system；Arranging machine 1 is connect with sheet pushing machine 2, and sheet pushing machine 2 is located at the one end in coating pond 3, coating pond 3
For circular arc type；Coating pond 3 is provided with coating solution 4；The entrance of tablet pipeline is connect with sheet pushing machine 2, the outlet and receipts of tablet pipeline
Acquisition means 5 connect, and medicine-tablet conveying device is used to convey the implant tablet in tablet pipeline.
The collection device 5 provided in the utility model is one piece of horizontal positioned plate, and collection device 5 and automatic control fill
Connection is set, automatic control device is moved horizontally for controlling collection device, and the material of collection device 5 is surface with Teflon
Stainless steel is highly anti-sticking, therefore can be to avoid the implant tablet fallen since collection device 5 is moveable
It will not repeat to fall in a spatial position, avoid conglutinate between implant tablet.
The implant coating device provided in the utility model further includes micro motor, and sheet pushing machine 2 is electrically connected with micro motor
It connects, push jack is equipped in sheet pushing machine 2, push jack is electrically connected with the automatic control device, and automatic control device is miniature for controlling
Motor drives push jack to push the movement of implant tablet.
The tablet pipeline provided in the utility model includes the first tablet pipeline 6, the second tablet pipeline 7, third tablet pipe
Road 8；First tablet pipeline 6, the second tablet pipeline 7, third tablet pipeline 8 are hard tube, and the hard tube material is stainless steel, the
One tablet pipeline 6, the second tablet pipeline 7, third tablet pipeline 8 are structure as a whole, the first tablet pipeline 6, the second tablet pipeline
7, third tablet pipeline 8 is sequentially connected；The entrance of first tablet pipeline 6 is connect with sheet pushing machine 2, the outlet of third tablet pipeline 8
It is connect with collection device 5.8 setting of third tablet pipeline inclination, tilt angle are 10-15 °.
The the first tablet pipeline 6 provided in the utility model is to be arranged in parallel, and 6 entrance of the first tablet pipeline and sheet pushing machine connect
It connects, the outlet of the first tablet pipeline 6 is connect with the entrance of the second tablet pipeline 7；Second tablet pipeline 7 is arc setting, is fitted in
In coating pond 3, third tablet pipeline 8 is to be obliquely installed.
7 bottom end of the second tablet pipeline provided in the utility model is fitted in 3 inside of coating pond, the leaching of the second tablet pipeline 7
Bubble is in coating liquid 4.7 length of the second tablet pipeline provided in the utility model is 30cm, and the second tablet pipeline 7, which is equipped with, to be caused
Close mesh, mesh density are at least 100/30cm；The diameter of mesh is 2mm.
The caliber of second tablet pipeline 7 is gradually smaller from entrance to exporting, the caliber of the second tablet pipeline 7 outlet and implantation
Agent Tablet diameter differs 1.5-2mm.When the caliber inlet of the second tablet pipeline 7 is than exporting big 0.9mm, the second tablet pipeline 7
Caliber exit 1.5mm bigger than implant Tablet diameter when, membrane wrapping thickness and integrity degree are more preferable.
The the second tablet pipeline 7 and third tablet pipeline 8 provided in the utility model be respectively arranged with the first push rod track,
Second push rod track；First push rod track is adapted with rotating push rod 11, and the first push rod track is the opening that width is 2mm, rotation
Turning 11 diameter of push rod is 1.5mm, and the second push rod track is adapted with translation push rod 12, and it is 2mm's that the second push rod track, which is width,
Opening, translation 12 diameter of push rod are 1.5mm.
Medicine-tablet conveying device provided by the utility model includes first driving device 9, rotating push rod 11, the second driving device
10, push rod 12 is translated, is provided with first driving device 9 at 3 center location of coating pond；7 upper end of third tablet pipeline is provided with
Two driving devices 10；First driving device 9 is electrically connected with automatic control device with the second driving device 10；
11 one end of rotating push rod is connect with first driving device 9, and the other end protrudes into the second tablet by the first push rod track
Pipeline 7；Translation 12 one end of push rod is connect with the second driving device 10, and the other end protrudes into third tablet rail by the second push rod track
Road 8.Rotating push rod 11, translation push rod 12 are the steel that outside has Teflon, and wherein Teflon is actually polytetrafluoroethyl-ne
The material of alkene.
The coating liquid 4 provided in the utility model is PLA solution, and PLA (polylactic acid) molecular weight in coating liquid 4 is 5-7
Ten thousand, the concentration of institute's PLA solution is 5-9%.
1 naltrexone implant coating process of embodiment
(1) polylactic acid that molecular weight is 60,000 is dissolved in methylene chloride, forms the coating liquid that concentration is 6%, is placed in coating
Chi Zhong, it is spare；
(2) naltrexone implant tablet is pushed into the first tablet pipeline by sheet pushing machine, subsequently enters the second tablet pipe
Implant tablet is moved to outlet from the second tablet entrance by first driving device and carries out coating by road, and the coating time is
30s, temperature are 37 DEG C.
Wherein, mesh density is 100/30cm on the second tablet pipeline；The diameter of the mesh is 2mm, the second tablet
0.9mm bigger than exit diameter at entrance, the second tablet pipeline exit diameter is more straight than naltrexone implant tablet
The big 1.5mm of diameter.
After measured, the film thickness of the naltrexone implant tablet obtained by above-mentioned coating device is 0.002-
0.003mm, coating integrity degree 100%.
A series of detailed description described above only for the utility model feasible embodiment it is specific
Illustrate, they are not to be had to limit the protection scope of the utility model in the technical field those of ordinary skill
Knowledge in, the various change made without departing from the purpose of the present invention belongs to the guarantor of the utility model
Protect range.
Claims (9)
1. a kind of implant coating device, which is characterized in that defeated including arranging machine, sheet pushing machine, coating pond, tablet pipeline, tablet
Send device, collection device, automatic control system；The arranging machine is connect with the sheet pushing machine, and the coating pond is circular arc type；Institute
It states coating pond and is provided with coating liquid；The entrance of the tablet pipeline is connect with the sheet pushing machine, the outlet of the tablet pipeline with
The collection device connection, the medicine-tablet conveying device are used to convey the implant tablet in tablet pipeline.
2. implant coating device as described in claim 1, which is characterized in that the collection device is one piece horizontal positioned
Plate, the collection device are connect with automatic control device, and automatic control device is moved horizontally for controlling collection device, described
The material of collection device is the stainless steel that surface has Teflon.
3. implant coating device as described in claim 1, which is characterized in that the tablet pipeline includes the first tablet pipe
Road, the second tablet pipeline, third tablet pipeline；The first tablet pipeline, the second tablet pipeline, third tablet pipeline are not
Become rusty steel pipe, and the first tablet pipeline, the second tablet pipeline, third tablet pipeline are structure as a whole, the first tablet pipeline,
Second tablet pipeline, third tablet pipeline are sequentially connected；
The entrance of the first tablet pipeline is connect with the sheet pushing machine, and the collection is protruded into the outlet of the third tablet pipeline
In device.
4. implant coating device as claimed in claim 3, which is characterized in that the second tablet pipeline is provided with first and pushes away
Bar track, the third tablet pipeline are provided with the second push rod track；The first push rod track and the second push rod track
It is the opening that width is 2mm.
5. implant coating device as claimed in claim 3, which is characterized in that the second tablet pipeline bottom end is fitted in institute
It states on the inside of coating pond, the second tablet pipeline is immersed in the coating liquid；The second tablet pipeline is equipped with mesh, institute
It states mesh density and is at least 100/30cm；The diameter of the mesh is 2mm.
6. implant coating device as claimed in claim 3, which is characterized in that the caliber of the second tablet pipeline is from entrance
It is gradually reduced to outlet, the caliber inlet of the second tablet pipeline is 0.5-1.5mm bigger than exit, the second tablet pipe
The caliber of road outlet is 1.5-2mm mutually bigger than the implant Tablet diameter.
7. implant coating device as claimed in claim 4, which is characterized in that the medicine-tablet conveying device includes the first driving
Device, rotating push rod, the second driving device, translation push rod, the coating Chi Yuanxinweizhichu are provided with first driving device；Institute
It states third tablet pipeline upper end and is provided with the second driving device；
The first driving device is electrically connected with the automatic control device with second driving device；
Described rotating push rod one end is connect with the first driving device, and the other end protrudes into described second by the first push rod track
Tablet pipeline；
Described translation push rod one end is connect with second driving device, and the other end protrudes into the third by the second push rod track
Tablet pipeline.
8. implant coating device as claimed in claim 7, which is characterized in that the rotating push rod, translation push rod are table
Face has the steel of Teflon, and the rotating push rod, the diameter for translating push rod are 1.5mm.
9. implant coating device as described in claim 1, which is characterized in that the coating liquid is PLA solution, the PLA
The concentration of solution is 5-9%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821358213.1U CN209596217U (en) | 2018-08-22 | 2018-08-22 | A kind of implant coating device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821358213.1U CN209596217U (en) | 2018-08-22 | 2018-08-22 | A kind of implant coating device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN209596217U true CN209596217U (en) | 2019-11-08 |
Family
ID=68393936
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201821358213.1U Active CN209596217U (en) | 2018-08-22 | 2018-08-22 | A kind of implant coating device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN209596217U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10702885B2 (en) * | 2018-08-22 | 2020-07-07 | Shenzhen ScienCare Medical Industries Co. Ltd. | Implant coating and drying device |
-
2018
- 2018-08-22 CN CN201821358213.1U patent/CN209596217U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10702885B2 (en) * | 2018-08-22 | 2020-07-07 | Shenzhen ScienCare Medical Industries Co. Ltd. | Implant coating and drying device |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR102558187B1 (en) | Systems and methods for the manufacture of tablets, including pharmaceutical tablets | |
| CN101199873B (en) | Medicament elution instrument nanometer class colon washer machineole drug releasing structure and preparing method thereof | |
| CN103108662B (en) | For equipment and the method for drug loading stripping property medical apparatus and instruments | |
| CN103153355B (en) | Apparatus and methods for loading a drug eluting medical device | |
| CN103122132B (en) | For the Bioabsorbable polymeric composition of medicine equipment | |
| IE872364L (en) | Controlled release device for an active substance. | |
| CN209596217U (en) | A kind of implant coating device | |
| CN108057408A (en) | A kind of reaction kettle for producing vitamin E | |
| JPH09501238A (en) | Device for simulating the shape change, disintegration and dissolution behavior of a medicated drug product, and the effect of the organism on the release of the active ingredient | |
| CN103108663A (en) | Apparatus and methods for loading a drug eluting medical device | |
| Cascone et al. | The influence of dissolution conditions on the drug ADME phenomena | |
| CN106580868A (en) | Implant and preparation method thereof | |
| KR20100063090A (en) | Galenical formulations of aliskiren and valsartan | |
| CN205970091U (en) | Can get rid of rotary tablet machine of useless piece, recovery dust in step | |
| CN209154526U (en) | A kind of implant coating and drying device | |
| Bogataj et al. | Development of a glass-bead device for dissolution testing | |
| CN110856691A (en) | Implant diolame device | |
| CN209475163U (en) | The automatic coating device of implant | |
| Huang et al. | Metoprolol tartrate sustained-release binary matrix microspheres for oral administration produced by novel ultra-fine particle processing system | |
| CN114768643B (en) | Medicine dissolving device for medicine analysis | |
| WO2020037727A1 (en) | Implant coating and drying device | |
| CN207078345U (en) | A kind of drawing mechanism for veterinary drug packing | |
| CN208212202U (en) | A kind of medical dose measuring equipment | |
| CN109298150B (en) | Special efficient rack for automatic release rate sampling system | |
| EP2320227B1 (en) | Dissolution apparatus comprising beads and process |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP01 | Change in the name or title of a patent holder | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 6G, 6th floor, central business building, 88 Fuhua 1st Road, Futian District, Shenzhen, Guangdong 518000 Patentee after: Shenzhen shankang Pharmaceutical Technology Co.,Ltd. Address before: 6G, 6th floor, central business building, 88 Fuhua 1st Road, Futian District, Shenzhen, Guangdong 518000 Patentee before: SHENZHEN SCIENCARE MEDICAL INDUSTRIES Co.,Ltd. |