CN109294868A - A kind of biological reaction container sampling device - Google Patents
A kind of biological reaction container sampling device Download PDFInfo
- Publication number
- CN109294868A CN109294868A CN201811142510.7A CN201811142510A CN109294868A CN 109294868 A CN109294868 A CN 109294868A CN 201811142510 A CN201811142510 A CN 201811142510A CN 109294868 A CN109294868 A CN 109294868A
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- China
- Prior art keywords
- reaction
- reaction vessel
- sampling device
- degree
- loading area
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
Abstract
The invention discloses a kind of biological reaction container sampling devices, comprising: reorganizer is spread out reaction vessel is smooth for smooth and opsonic reaction container loading area；Shifter is moved to the workspace of applicator for the uncoated region by reaction vessel；Pipettor, for reaction system to be moved to reaction vessel surface；Applicator, for coating and being sealed in the reaction chamber of reaction vessel by the reaction system for having moved into reaction vessel surface.By reaction system liquid by being loaded into reaction system drop in the micropore of reaction vessel, and micropore is closed on the carrier band uniformly coated in reaction vessel, several independent reaction chambers are formed.The sampling device can continuous loading, solve the problems, such as that previous similar sampling device applied sample amount is lesser.
Description
Technical field
The present invention relates to the anti-sampling device of biology, especially biological band-like biological reaction container sampling devices.
Background technique
When small molecule, nucleic acid, albumen, Bacteria Detection, biological respinse system is such as distributed to multiple reacting holes and is carried out instead
It answers, when existing equipment is loaded into reaction chamber, because of reaction vessel and loading equipment deficiency, can only generally carry out micro-reaction system
Load, many reaction systems or sample cannot completely embody the biology of reaction system or sample because could not previously be loaded into reaction vessel
Feature.
Summary of the invention
The invention mainly solves the technical problem of providing a kind of biological reaction container sampling device, which can be with
Continuous loading solves the problems, such as that previous similar sampling device applied sample amount is lesser.
In order to solve the above technical problems, The technical solution adopted by the invention is as follows: a kind of biological reaction container sampling device,
Include:
Reorganizer is spread out reaction vessel is smooth for smooth and opsonic reaction container loading area；
Shifter is moved to the workspace of applicator for the uncoated region by reaction vessel；
Pipettor, for reaction system to be moved to reaction vessel surface；
Applicator, for being coated the reaction system for having moved into reaction vessel surface and being sealed to the reaction chamber of reaction vessel
It is interior.
Further, the reaction vessel includes carrier band and base band, has several micropores, the base on the carrier band
Band covers the surface that carrier band has micropore, so that micropore is formed confined reaction room in conjunction with carrier band micropore.
Further, the base band is combined by applicator with carrier band, and micropore is made to form confined reaction room, base band and carrier band
The normal angles of junction are 0~90 degree, preferably 60 degree.
Further, the base band is fixed together with carrier band by illumination, heating, bonding, hook mode, makes the two not
It can be mutually shifted, and become combination and enclosed reaction chamber.
It further, further include blade, blade will be preset at the reaction system liquid in reaction vessel loading area from a side
To another or multi-party direction is moved to, reaction system is made to be evenly distributed to reaction vessel loading area in advance.
Further, whether the blade with base band by contacting and be divided into scraper and air knife；
The normal angle of the carrier band of the scraper and reaction vessel is 15~135 degree, and preferred value is 45 degree；
The angle in the loading area of the air knife and reaction vessel is 90~180 degree, preferably 135 degree；Reaction vessel
Loading area angle with horizontal plane is 0~45 degree, preferably 30 degree.
Further, the scraper feeler be 60~140, preferably 110 degree；The air knife blows to loading area using air pressure,
The pressure adjustable of air pressure, the shape that air pressure blows to loading area is dotted, linear or gradient planar, preferably linear air knife.
Further, the reorganizer can also adjust the temperature in loading area.
Further, the reorganizer has resistance wheel, and resistance wheel makes area of the reaction vessel between shifter and reorganizer
Domain is smooth, and reorganizer can have liner, and liner can set constant temperature, preferably there is constant temperature liner.
The invention has the advantages that: under shifter driving, reaction vessel is continuous feed, and pipettor also can be moved continuously
Liquid, blade continuously spread reaction system in advance, and applicator continuously coats and enclosed reaction chamber, it is compact-sized can continuous loading, behaviour
It is low to make the small possibility of pollution in space, a large amount of loadings of energy, preferably air knife, without other auxiliary in addition to necessary pipettor and reaction vessel
Equipment is contacted with reaction system, reduces possibility of pollution, also not additional complementary consumptive material.Pipettor operating efficiency is high, has
Local steady temperature protects sampling condition, and sample introduction uniformity and consistency are good.
Detailed description of the invention
Fig. 1 is sampling device structural schematic diagram of the present invention；
The components in the drawings are labeled as follows: reorganizer 1, pipettor 3, applicator 4, blade 5, base band 6, carries shifter 2
Band 7, illumination 8, reaction system 9, micropore 10.
Specific embodiment
Example embodiments are described in detail here, and the example is illustrated in the accompanying drawings.Following description and attached
When figure, unless otherwise indicated, the same numbers in different drawings indicate the same or similar elements.In following exemplary embodiment
Described embodiment does not represent all embodiments consistented with the present invention.On the contrary, they be only with it is such as appended
It is described in detail in middle claims, the example of the consistent device of some aspects of the invention.Each implementation of this specification
Example is described in a progressive manner.
It in addition, the technical solution between each embodiment can be combined with each other, but must be with ordinary skill
Based on personnel can be realized, this technical side will be understood that when the combination of technical solution appearance is conflicting or cannot achieve
The combination of case is not present, also not the present invention claims protection scope within.
Referring to Fig. 1, a kind of biological reaction container sampling device, the device include:
Reorganizer 1 is spread out reaction vessel is smooth for smooth and opsonic reaction container loading area；
Shifter 2 is moved to the workspace of applicator 4 for the uncoated region by reaction vessel；
Pipettor 3, for reaction system 9 to be moved to reaction vessel surface；
Applicator 4, for coating and being sealed in reaction chamber by the reaction system 9 for having moved into reaction vessel surface；
Reorganizer 1 is smooth and opsonic reaction container loading area, spreads out reaction vessel is smooth, and shifter 2 is by reaction vessel
10 region of uncoated microporous move to the workspace of applicator 4, reaction system 9 is moved to reaction vessel surface by pipettor 3, is coated
Device 4 passes through scraper or the mobile loading that the reaction system 9 for having moved into reaction vessel surface is uniformly coated to reaction vessel of air knife
When area, reaction vessel are mobile, using the angle of base band 6 and carrier band 7, by reaction system 9, uniformly distribution is while close to reaction chamber
Reaction chamber is sealed, closed reaction vessel is formed.
Specifically, the reaction vessel includes base band 6 and carrier band 7, there are several micropores 10 on the carrier band 7, it is described
Base band 6 finally cover carrier band 7 with micropore 10 surfaces, with carrier band 7 micropores 10 is combined make micropore 10 formation confined reaction room,
The base band 6 is combined by applicator 4 with carrier band 7, and micropore 10 is made to form confined reaction room, the method for 7 junctions of base band 6 and carrier band
It is 0~90 degree, preferably 60 degree to angle.The orifice shapes of the micropore 10 are default arbitrary shape, can be rule or/it is right
Claim figure, generally circular in cross section, rectangular, rectangle, triangle, hexagon, diamond shape, parallelogram, irregular figure, preferably six
Side shape.The Zhou Changwei 4um to 40mm of micropore 10, the depth in hole are generally 1um to 10mm, hole density be generally 1-50000/
cm2, the both ends size in hole can be different, allow hole wall gradient；It is preferred that hole perimeter 200um, hole depth 200um, hole density 5000
A/cm.
When the base band 6 passes through applicator 4 with carrier band 7, applicator presses base band 6 and 7 tight bonds of carrier band or hook,
In some instances, using illumination 8 and or applicator heat secondary combined, so that base band 6 and carrier band 7 is fixed together, make the two
It cannot be mutually shifted, and become combination and enclosed reaction chamber.Meanwhile according to the combination of the base band of reaction vessel 6 and carrier band 7
Mode, the optional illumination 8 of sampling device combine base band 6 and the photosensitive viscose of carrier band 7 rapidly, are conducive to reinforce the close of reaction chamber
Envelope；Meanwhile according to the combination of the base band of reaction vessel 6 and carrier band 7, the applicator 4 of the optional heating function of sampling device adds
Fast binding speed is conducive to the sealing for accelerating reaction chamber.
Applicator 4 further includes blade 5, and blade 5 is used to be preset at 9 liquid of reaction system in reaction vessel loading area from one
A direction moves to another or multi-party direction, and reaction system 9 is made to be evenly distributed to reaction vessel loading area in advance.The blade
Whether 5 with base band 6 by contacting and be divided into scraper (contact) and air knife (not contacting)；
For the edge length of the scraper not less than the cross-section lengths of carrier band 7, scraper is that section is to carve type, scraper loading face
It is preferred that there is diversion trench, the reaction system for dripping to blade surface 9 can be made to be evenly dispersed to carve type point of a knife；The scraper and anti-
The normal angle for answering the carrier band 7 of container is 15~135 degree, and representative value is 45 degree, and the reaction system 9 for keeping pipettor 3 mobile is along knife
Cutting edge of a knife or a sword direction is mobile, and then predistribution is to 7 surfaces are carried in carrying 7 moving process, because the micropore 10 of reaction vessel is hydrophily,
Reaction system 9 enters the micropore 10 of reaction vessel；The scraper into contact angle be 60~140, preferably 110 degree.
The angle in the loading area of the air knife and reaction vessel is 90~180 degree, preferably 135 degree；The loading of container
Area's angle with horizontal plane is 0~45 degree, preferably 30 degree.The air knife blows to loading area, the pressure adjustable of air pressure, gas using air pressure
It is dotted, linear or gradient planar that pressure, which blows to the shape in loading area, preferably linear air knife.Air knife section is to carve type, inside air knife
It is hollow, air knife can be made to carve type section by air-flow and discharge gas, the gas of discharge generates power, make air knife with react appearance
When 9 uniformly dispersing of reaction system between device, reaction vessel and air knife carve type face and mutually generate displacement, the gas work of air knife blowout
Reaction system 9 is moved round about for power, in moving process, because the micropore 10 of reaction vessel is hydrophily, reaction
System 9 enters the micropore 10 of reaction vessel.
Scraper and air knife can make reaction system 9 be evenly dispersed to reaction vessel surface and enter micropore 10, not enter
The reaction system 9 of micropore 10 continues, completion reactant mobile to other reacting holes under the cutter force of scraper or air knife
It is 9 pre-fill, preferably air knife.
Reaction system 9 is moved to reaction vessel surface by pipettor 3, and blade 5 is pre-dispersed to reaction vessel by reaction system 9,
Reaction vessel moves under the drive of shifter 2, and respectively in reaction vessel two sides, shifter 2 turns for shifter 2 and applicator 4
Driving wheel and the rotating wheel axial connecting line of applicator 4 are vertical with reaction vessel, and the rotating wheel of shifter 2 belongs to driving wheel, dynamic
Traction reaction vessel moves obliquely, and the rotating wheel of applicator 4 can be driving wheel and be also possible to follower, preferably follower,
It is rotated using the pressure or/and frictional force of two wheels with shifter 2.The rotating wheel of applicator 4 has along two axis directions can
Elastic force is adjusted, the driving wheel of the follower and shifter 2 that make applicator 4 always keeps pressure to pass through pressure when reaction vessel is mobile
Power is that the base band 6 of reaction vessel and carrier band 7 are closely combined together.Base band 6 between applicator 4, is coated positioned at carrier band 7
When 4 follower of device rotates, base band 6 is combined with carrier band 7 therewith, and will fail equally distributed reaction system 9 to remaining reacting hole
Distribution, after base band 6 is combined with carrier band 7, reaction system 9 forms reaction chamber in the micropore 10 of base band 6 and carrier band 7.
Reaction vessel is laid in 1 plane of reorganizer, and the reorganizer 1 has resistance wheel, and resistance wheel is being displaced reaction vessel
Region between device 2 and reorganizer 1 is smooth, and reorganizer 1 can have liner, and liner can set constant temperature, preferably there is constant temperature liner.
1 working face of reorganizer and horizontal plane have angle, and angle a is generally 0~45 °, preferably 30 °, so that reaction vessel
Loading area angle with horizontal plane is same.
Reorganizer 1 is to carry 7 plummer, while also providing the function of temperature control of constant temperature, and reaction solution is made to be maintained at given
Temperature condition, keep reaction solution and carrier band 7 work under the operating condition of constant temperature, the temperature range of reorganizer 1 be generally 4 °~
95 ° preferably 25 degree, under characteristic reactions system 9, it can choose 95 °.
The above description is only an embodiment of the present invention, is not intended to limit the scope of the invention, all to utilize this hair
Equivalent structure or equivalent flow shift made by bright specification and accompanying drawing content is applied directly or indirectly in other relevant skills
Art field, is included within the scope of the present invention.
Claims (9)
1. a kind of biological reaction container sampling device characterized by comprising
Reorganizer is spread out reaction vessel is smooth for smooth and opsonic reaction container loading area；
Shifter is moved to the workspace of applicator for the uncoated region by reaction vessel；
Pipettor, for reaction system to be moved to reaction vessel surface；
Applicator, for coating and being sealed in the reaction chamber of reaction vessel by the reaction system for having moved into reaction vessel surface.
2. a kind of biological reaction container sampling device according to claim 1, which is characterized in that the reaction vessel includes
Carrier band and base band have several micropores on the carrier band, and the base band covers the surface that carrier band has micropore, micro- with carrying
Hole, which combines, makes micropore form confined reaction room.
3. a kind of biological reaction container sampling device according to claim 1, which is characterized in that the base band passes through coating
Device with carrier band is combined, make micropore formed confined reaction room, base band and carrier band junction normal angles be 0 ~ 90 degree, preferably 60
Degree.
4. a kind of biological reaction container sampling device according to claim 1, which is characterized in that the base band and carrier band are logical
Cross illumination, heating, bonding, hook mode are fixed together.
5. a kind of biological reaction container sampling device according to claim 1, which is characterized in that further include blade, blade
The reaction system liquid for being preset at reaction vessel loading area is moved into another or multi-party direction from a direction, makes reactant
System is evenly distributed to reaction vessel loading area in advance.
6. a kind of biological reaction container sampling device according to claim 5, which is characterized in that the blade by whether with
Base band contact is divided into scraper and air knife；
The normal angle of the carrier band of the scraper and reaction vessel is 15 ~ 135 degree, and preferred value is 45 degree；
The angle in the loading area of the air knife and reaction vessel is 90 ~ 180 degree, preferably 135 degree；The loading area of reaction vessel
Angle with horizontal plane is 0 ~ 45 degree, preferably 30 degree.
7. a kind of biological reaction container sampling device according to claim 6, which is characterized in that the scraper feeler is 60
~ 140, preferably 110 degree；The air knife blows to loading area, the pressure adjustable of air pressure using air pressure, and air pressure blows to the shape in loading area
It is dotted, linear or gradient planar, preferably linear air knife.
8. a kind of biological reaction container sampling device according to claim 1, which is characterized in that the reorganizer can be with
Adjust the temperature in loading area.
9. a kind of biological reaction container sampling device according to claim 1, which is characterized in that the reorganizer has resistance
Wheel, resistance wheel keep region of the reaction vessel between shifter and reorganizer smooth, and reorganizer can have liner, and liner can be set
Determine constant temperature, preferably there is constant temperature liner.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811142510.7A CN109294868B (en) | 2018-09-28 | 2018-09-28 | Sample loading device of biological reaction container |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811142510.7A CN109294868B (en) | 2018-09-28 | 2018-09-28 | Sample loading device of biological reaction container |
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| Publication Number | Publication Date |
|---|---|
| CN109294868A true CN109294868A (en) | 2019-02-01 |
| CN109294868B CN109294868B (en) | 2021-11-19 |
Family
ID=65164872
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811142510.7A Active CN109294868B (en) | 2018-09-28 | 2018-09-28 | Sample loading device of biological reaction container |
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| CN109294868B (en) | 2021-11-19 |
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