CN220371065U - Microfluidic hybrid structure and microfluidic chip device - Google Patents

Abstract

The utility model provides a microfluidic mixing structure and a microfluidic chip device. The microfluidic mixing structure comprises: the first mixing part is provided with a first liquid passing port, a first flow channel and a second liquid passing port; the second mixing part is provided with a third liquid passing port, at least two second flow passages and a fourth liquid passing port; the second liquid passing port of one first mixing part is communicated with the third liquid passing port of at least one second mixing part to form a first mixing unit, the second liquid passing port of one first mixing part is communicated with the first liquid passing port of at least one other first mixing part to form a second mixing unit, the fourth liquid passing port of one second mixing part is communicated with the first liquid passing port of at least one first mixing part to form a third mixing unit, and the fourth liquid passing port of one second mixing part is communicated with the third liquid passing port of at least one other second mixing part to form a fourth mixing unit. The utility model solves the problem of lower mixing effect of the connection of the microfluidic mixing units in the prior art.

Description

Microfluidic hybrid structure and microfluidic chip device

Technical Field

The utility model relates to the technical field of microfluidic chips, in particular to a microfluidic mixing structure and a microfluidic chip device.

Background

At present, as an emerging technology, a microfluidic technology can integrate complex physical, chemical and biological processes into a very small microfluidic chip, called a lab-on-a-chip, by precisely manipulating a fluid on a micro scale. In order to realize the functions of chemical reaction, detection and the like, the mixing of various materials is one of the very important processes, so that the microfluidic mixer is an important and basic microfluidic device, and the core of the design of the microfluidic mixer is to design a microfluidic mixing structure. Most of the existing microfluidic mixed structures are focused on the design of the flow channel structures of the basic microfluidic mixed units, a large number of effective microfluidic mixed units have been designed, but the combination strategy design of different mixed units is ignored.

However, the current connection manner of the microfluidic mixing units is simpler, and only a simple serial connection of a plurality of completely identical microfluidic mixing units is generally adopted to enhance the mixing effect, or a simple parallel connection of a plurality of completely identical microfluidic mixing structures is generally adopted to increase the throughput. For a certain specific microfluidic mixing structure, the interior of the microfluidic mixing structure is always provided with a dead zone, a low-mixing-degree area and other structures, when only the same microfluidic mixing units are connected in series, partial fluid always flows through the areas with poor mixing, the mixing effect is weak, the mixing efficiency of the whole microfluidic mixing structure is reduced, and more mixing units are needed to realize complete mixing of various liquids.

Disclosure of Invention

The utility model mainly aims to provide a microfluidic mixing structure and a microfluidic chip device, which are used for solving the problem of low mixing effect of connection of a plurality of identical microfluidic mixing units in the prior art.

To achieve the above object, according to one aspect of the present utility model, there is provided a microfluidic mixing structure comprising: the first mixing part is provided with a first liquid passing port, a first flow passage and a second liquid passing port, and the first liquid passing port is communicated with the second liquid passing port through the first flow passage; the second mixing part is provided with a third liquid passing port, at least two second flow passages and a fourth liquid passing port, the at least two second flow passages are oppositely arranged, and the third liquid passing port is communicated with the fourth liquid passing port through each second flow passage; the second liquid passing port of one first mixing part is communicated with the third liquid passing port of at least one second mixing part to form a first mixing unit, the second liquid passing port of one first mixing part is communicated with the first liquid passing port of at least one other first mixing part to form a second mixing unit, the fourth liquid passing port of one second mixing part is communicated with the first liquid passing port of at least one first mixing part to form a third mixing unit, and the fourth liquid passing port of one second mixing part is communicated with the third liquid passing port of at least one other second mixing part to form a fourth mixing unit; one first mixing unit may be selectively in communication with the other first, second, third and fourth mixing units; and/or one second mixing unit may be in selective communication with another second mixing unit, a third mixing unit, and a fourth mixing unit; and/or, one third mixing unit can be selectively communicated with the other third mixing unit and the fourth mixing unit; and/or one fourth mixing unit may be selectively in communication with another fourth mixing unit.

Further, the microfluidic mixing structure further comprises: the first communicating part is provided with a first liquid passing channel, and the second liquid passing port of one first mixing part is communicated with the first liquid passing port of the other first mixing part through the first liquid passing channel; or the second liquid passing port is communicated with the third liquid passing port through the first liquid passing channel; or the fourth liquid passing port of one second mixing part is communicated with the third liquid passing port of the other second mixing part through the first liquid passing channel; or the fourth liquid passing port is communicated with the first liquid passing port through the first liquid passing channel.

Further, the microfluidic mixing structure further comprises: the second communicating part is provided with at least two second liquid passing channels, and the second liquid passing port is communicated with at least two third liquid passing ports through the at least two second liquid passing channels; or the second liquid passing port of one first mixing part is communicated with the first liquid passing ports of at least two other first mixing parts through at least two second liquid passing channels; or the fourth liquid passing port is communicated with at least two first liquid passing ports through at least two second liquid passing channels; or the fourth liquid passing port of one second mixing part is communicated with the third liquid passing ports of at least two other second mixing parts through at least two second liquid passing channels; wherein, at least two second liquid passages are mutually connected in parallel.

Further, the first mixing section includes: the first runner of the first sub-mixing part is in a zigzag shape.

Further, the first flow channel of the first sub-mixing part comprises a first sub-flow channel, a second sub-flow channel and a third sub-flow channel which are bent and communicated in sequence, the first sub-flow channel and the third sub-flow channel are arranged oppositely, and the first sub-flow channel and the third sub-flow channel are located on the same side of the second sub-flow channel.

Further, the first sub-runner comprises a first runner section and a second runner section which are bent and communicated in sequence, one end of the first runner section, which is far away from the second runner section, is provided with a first liquid passing port, and the first runner section and the second sub-runner are respectively positioned at two sides of the second runner section; and/or the third sub-runner comprises a third runner section and a fourth runner section which are bent and communicated in sequence, one end of the fourth runner section, which is far away from the third runner section, is provided with a second liquid passing port, and the fourth runner section and the second sub-runner are respectively positioned at two sides of the third runner section.

Further, the first mixing section further includes: and the first runner of the second sub-mixing part is arc-shaped.

Further, the first flow channel of the second sub-mixing part comprises a fourth sub-flow channel, a fifth sub-flow channel and a sixth sub-flow channel which are bent and communicated in sequence, the fourth sub-flow channel and the sixth sub-flow channel are arranged oppositely, and the fourth sub-flow channel and the sixth sub-flow channel are all located on the same side of the fifth sub-flow channel.

Further, the second mixing section includes: the first sub-arc-shaped flow channel is provided with at least one second flow channel; the second sub-arc-shaped flow passage is arranged opposite to and communicated with the first sub-arc-shaped flow passage, the second sub-arc-shaped flow passage is provided with at least one second flow passage, and the middle part of the second sub-arc-shaped flow passage is provided with a fan-shaped expanding section.

According to another aspect of the present utility model, there is provided a microfluidic chip device comprising the microfluidic mixing structure described above.

Further, the device also comprises a real-time monitoring device, and the mixing condition of the liquid in the chip is monitored in real time by using the tracer molecules and the real-time monitoring device.

Further, the real-time monitoring device selects at least one of the first liquid passing port, the second liquid passing port, the third liquid passing port and the fourth liquid passing port as a real-time monitoring sampling area.

Further, the real-time monitoring device selects fluorescent small molecules dissolved in the liquid as marker molecules, and selects a fluorescent inverted microscope as detection equipment.

Further, the real-time monitoring device reads fluorescence intensity data from the detection equipment by using a computer, automatically processes the data by using a computer program, judges the mixing effect in real time and outputs the mixing effect.

By applying the technical scheme of the utility model, the microfluidic mixing structure comprises a first mixing part and a second mixing part, wherein the first mixing part is provided with a first liquid passing port, a first flow passage and a second liquid passing port, and the first liquid passing port is communicated with the second liquid passing port through the first flow passage. The second mixing part is provided with a third liquid passing port, at least two second flow passages and a fourth liquid passing port, the at least two second flow passages are oppositely arranged, and the third liquid passing port is communicated with the fourth liquid passing port through each second flow passage. The second liquid passing port of one first mixing part is communicated with the third liquid passing port of at least one second mixing part to form a first mixing unit, the second liquid passing port of one first mixing part is communicated with the first liquid passing port of at least one other first mixing part to form a second mixing unit, the fourth liquid passing port of one second mixing part is communicated with the first liquid passing port of at least one first mixing part to form a third mixing unit, and the fourth liquid passing port of one second mixing part is communicated with the third liquid passing port of at least one other second mixing part to form a fourth mixing unit. In this way, one first mixing unit may be selectively in communication with the other first, second, third and fourth mixing units; and/or one second mixing unit may be in selective communication with another second mixing unit, a third mixing unit, and a fourth mixing unit; and/or, one third mixing unit can be selectively communicated with the other third mixing unit and the fourth mixing unit; and/or one fourth mixing unit can be selectively communicated with the other fourth mixing unit, so that the microfluidic mixing structure has a combination mode of a plurality of mixing units, the problem of lower mixing effect of connection of a plurality of identical microfluidic mixing units in the prior art is solved, and the mixing effect and mixing uniformity of the microfluidic mixing structure are improved.

Drawings

The accompanying drawings, which are included to provide a further understanding of the utility model and are incorporated in and constitute a part of this specification, illustrate embodiments of the utility model and together with the description serve to explain the utility model. In the drawings:

fig. 1 shows a schematic structural diagram of a first sub-mixing part of a microfluidic mixing structure according to the present utility model;

fig. 2 shows a schematic structural diagram of a second sub-mixing part of the microfluidic mixing structure according to the present utility model;

fig. 3 shows a schematic structural diagram of a second mixing part of the microfluidic mixing structure according to the present utility model;

fig. 4 shows a schematic structural diagram of a first communication part of a microfluidic hybrid structure according to the present utility model;

fig. 5 shows a schematic structural diagram of an embodiment of a second communication part of a microfluidic hybrid structure according to the present utility model;

fig. 6 shows a schematic structural diagram of another embodiment of a second communication part of a microfluidic hybrid structure according to the present utility model;

fig. 7 shows a schematic diagram of a CDCDCD-type structure of a microfluidic hybrid structure provided according to the present utility model;

fig. 8 shows a schematic diagram of a microfluidic mixing structure according to the present utility model in which a first mixing section and a second mixing section are connected in series.

Wherein the above figures include the following reference numerals:

10. a first mixing section; 11. a first liquid passing port; 12. a first flow passage; 13. a second liquid passing port; 14. a first sub-mixing section; 141. a first sub-flow path; 1411. a first flow path section; 1412. a second flow path section; 142. a second sub-flow path; 143. a third sub-flow path; 1431. a third flow path segment; 1432. a fourth flow path segment; 15. a second sub-mixing section; 151. a fourth sub-flow path; 152. a fifth sub-flow path; 153. a sixth sub-flow path;

20. a second mixing section; 21. a third liquid passing port; 22. a second flow passage; 23. a fourth liquid passing port; 24. a first sub-arcuate flow path; 25. a second sub-arc flow path; 26. a sector-shaped expanding section;

30. a first communication section;

40. a second communication portion.

Detailed Description

It should be noted that, in the case of no conflict, the embodiments and features in the embodiments may be combined with each other. The utility model will be described in detail below with reference to the drawings in connection with embodiments.

In order to solve the problem that the mixing effect of the connection of a plurality of identical microfluidic mixing units in the prior art is low, the application provides a microfluidic mixing structure and a microfluidic chip device.

As shown in fig. 1 to 8, the microfluidic mixing structure includes a first mixing part 10 and a second mixing part 20. The first mixing section 10 has a first liquid passing port 11, a first flow passage 12, and a second liquid passing port 13, and the first liquid passing port 11 communicates with the second liquid passing port 13 through the first flow passage 12. The second mixing section 20 has a third liquid passing port 21, at least two second flow passages 22, and a fourth liquid passing port 23, the at least two second flow passages 22 are disposed opposite to each other, and the third liquid passing port 21 communicates with the fourth liquid passing port 23 through each second flow passage 22. Wherein the second liquid passing port 13 of one first mixing part 10 is communicated with the third liquid passing port 21 of at least one second mixing part 20 to form a first mixing unit, the second liquid passing port 13 of one first mixing part 10 is communicated with the first liquid passing port 11 of at least another first mixing part 10 to form a second mixing unit, the fourth liquid passing port 23 of one second mixing part 20 is communicated with the first liquid passing port 11 of at least one first mixing part 10 to form a third mixing unit, and the fourth liquid passing port 23 of one second mixing part 20 is communicated with the third liquid passing port 21 of at least another second mixing part 20 to form a fourth mixing unit. One first mixing unit may be selectively in communication with the other first, second, third and fourth mixing units; and/or one second mixing unit may be in selective communication with another second mixing unit, a third mixing unit, and a fourth mixing unit; and/or, one third mixing unit can be selectively communicated with the other third mixing unit and the fourth mixing unit; and/or one fourth mixing unit may be selectively in communication with another fourth mixing unit.

By applying the technical scheme of the embodiment, one first mixing unit can be selectively communicated with the other first mixing unit, the second mixing unit, the third mixing unit and the fourth mixing unit; and/or one second mixing unit may be in selective communication with another second mixing unit, a third mixing unit, and a fourth mixing unit; and/or, one third mixing unit can be selectively communicated with the other third mixing unit and the fourth mixing unit; and/or one fourth mixing unit can be selectively communicated with the other fourth mixing unit, so that the microfluidic mixing structure has a combination mode of a plurality of mixing units, the problem of lower mixing effect of connection of a plurality of identical microfluidic mixing units in the prior art is solved, and the mixing effect and mixing uniformity of the microfluidic mixing structure are improved.

It should be noted that, along the flow direction of the medium in the microfluidic mixing structure, the communication between the first mixing unit and the second mixing unit in the present application includes a communication mode of passing through the first mixing unit and then passing through the second mixing unit, and a communication mode of passing through the second mixing unit and then passing through the first mixing unit.

Optionally, one of the first mixing units may be selectively connected to the other of the first mixing unit, the second mixing unit, the third mixing unit and the fourth mixing unit along the flow direction of the medium in the microfluidic mixing structure; and/or one of the second mixing units is selectively connectable to the first mixing unit, the other of the second mixing units, the third mixing unit and the fourth mixing unit; and/or one of the third mixing units may be selectively connected to the first mixing unit, the second mixing unit, the other of the third mixing unit, the fourth mixing unit; and/or one of the fourth mixing units may be selectively connected to the first mixing unit, the second mixing unit, the third mixing unit, and the other of the fourth mixing units.

In this embodiment, the microfluidic mixing units are formed by communicating the plurality of mixing units in a one-to-one correspondence manner, a suitable interlayer liquid exchange structure is arranged, and three-dimensional combination of the microfluidic mixing units can be realized by overlapping the plurality of microfluidic mixing units. The micro-fluidic chip is generally extremely thin and approximately can be regarded as a two-dimensional sheet structure, and the micro-fluidic chip with a complex three-dimensional structure is difficult to obtain, so that the three-dimensional combination is regarded as expansion of the mixing mode.

As shown in fig. 4, the microfluidic mixing structure further comprises a first communication part 30. Wherein, the first communicating part 30 is provided with a first liquid passing channel, and the second liquid passing port 13 of one first mixing part 10 is communicated with the first liquid passing port 11 of the other first mixing part 10 through the first liquid passing channel; alternatively, the second liquid passing port 13 is communicated with the third liquid passing port 21 through the first liquid passing channel; alternatively, the fourth liquid passing port 23 of one second mixing part 20 communicates with the third liquid passing port 21 of the other second mixing part 20 through the first liquid passing passage; alternatively, the fourth liquid passing port 23 communicates with the first liquid passing port 11 through the first liquid passing passage. In this way, the above arrangement makes the communication mode of the first communication part 30 more diversified on one hand, so as to meet the combination requirements of different mixing units of the microfluidic mixing structure; on the other hand, the first communicating portion 30 is for performing one-to-one communication (communication between one mixing unit and another mixing unit) to form a single flow passage.

As shown in fig. 5 and 6, the microfluidic mixing structure further includes a second communication part 40. The second communicating portion 40 has at least two second liquid passing passages, and the second liquid passing port 13 communicates with at least two third liquid passing ports 21 through the at least two second liquid passing passages; alternatively, the second liquid passing port 13 of one first mixing part 10 communicates with the first liquid passing ports 11 of at least two other first mixing parts 10 through at least two second liquid passing channels; alternatively, the fourth liquid passing port 23 is communicated with at least two first liquid passing ports 11 through at least two second liquid passing channels; alternatively, the fourth liquid passing port 23 of one second mixing part 20 communicates with the third liquid passing ports 21 of at least two other second mixing parts 20 through at least two second liquid passing passages. Wherein, at least two second liquid passages are mutually connected in parallel. In this way, the above arrangement makes the communication mode of the second communication part 40 more diversified on one hand, so as to meet the combination requirements of different mixing units of the microfluidic mixing structure; on the other hand, the second communication portion 40 is for performing one-to-two communication (communication between one mixing unit and the other two mixing units) or one-to-many communication (communication between one mixing unit and a plurality of mixing units) to form at least two flow passages.

As shown in fig. 1, the first mixing section 10 includes a first sub-mixing section 14. Wherein the first flow passage 12 of the first sub-mixing part 14 has a zigzag shape. Alternatively, the first flow passage 12 of the first sub-mixing section 14 has a U-shape.

As shown in fig. 1, the first flow channel 12 of the first sub-mixing section 14 includes a first sub-flow channel 141, a second sub-flow channel 142, and a third sub-flow channel 143 that are bent and connected in order, the first sub-flow channel 141 and the third sub-flow channel 143 are disposed opposite to each other, and the first sub-flow channel 141 and the third sub-flow channel 143 are located on the same side of the second sub-flow channel 142. In this way, the above arrangement makes the structure of the first flow channel 12 of the first sub-mixing part 14 simpler, and is easy to process and implement, thereby reducing the processing cost and processing difficulty of the first flow channel 12.

As shown in fig. 1, the first sub-flow channel 141 includes a first flow channel section 1411 and a second flow channel section 1412 which are sequentially bent and communicated, one end of the first flow channel section 1411 away from the second flow channel section 1412 is a first liquid passing port 11, and the first flow channel section 1411 and the second sub-flow channel 142 are respectively positioned at two sides of the second flow channel section 1412; and/or, the third sub-runner 143 includes a third runner section 1431 and a fourth runner section 1432 that are bent and communicated in sequence, one end of the fourth runner section 1432 away from the third runner section 1431 is a second liquid passing port 13, and the fourth runner section 1432 and the second sub-runner 142 are respectively located at two sides of the third runner section 1431. Like this, the structure that above-mentioned setting made first sub-runner 141 and/or third sub-runner 143 is more diversified to satisfy different user demands and operating mode, also promoted staff's processing flexibility.

As shown in fig. 2, the first mixing section 10 further comprises a second sub-mixing section 15. Wherein the first flow channel 12 of the second sub-mixing part 15 is arc-shaped. Alternatively, the first flow channel 12 of the second sub-mixing section 15 is U-shaped.

In this embodiment, along the medium flow direction in the microfluidic mixing structure, each mixing unit may be arranged and combined at will, so that the mixing mode of the microfluidic mixing structure is more diversified, so as to meet different use requirements and working conditions, and also improve the processing flexibility of the staff.

Specifically, the second mixing unit includes a first sub-mixing unit and a second sub-mixing unit, the first sub-mixing portion 14 is labeled as a mixing unit C, the second sub-mixing portion 15 is labeled as a mixing unit D, the second liquid passing port 13 of one first sub-mixing portion 14 is communicated with the first liquid passing port 11 of one second sub-mixing portion 15 to form a first sub-mixing unit, and the five first sub-mixing units are sequentially communicated to form a CDCDCDCDCD combination of 10 microfluidic mixing units. At a total flow rate of 40ml/h, water and 0.02% rhodamine B ethanol solution were introduced from both sides, respectively, and after the end of the mixing section, the final mixing result was observed and compared with the original only 10 mixing units C or D in series), and it was found that: the structure of the tandem mixing unit C alone can achieve mixing, but only a small amount of colored ethanol solution enters at the edge, which is significantly darker than the center of the channel, and the channel edge has poor mixing effect due to dead zone. The CDCDCDCDCD type structure can realize mixing, and the edge has no obvious dark area, so that the mixing effect is better than that of the original simple serial structure. Wherein the degree of mixing increases from about 0.7 to about 0.9, from partial mixing to complete mixing.

As shown in fig. 2, the first flow channel 12 of the second sub-mixing part 15 includes a fourth sub-flow channel 151, a fifth sub-flow channel 152 and a sixth sub-flow channel 153 which are bent and communicated in order, the fourth sub-flow channel 151 and the sixth sub-flow channel 153 are disposed opposite to each other, and the fourth sub-flow channel 151 and the sixth sub-flow channel 153 are located on the same side of the fifth sub-flow channel 152. In this way, the above arrangement makes the structure of the first flow channel 12 of the second sub-mixing part 15 simpler, and is easy to process and implement, thereby reducing the processing cost and processing difficulty of the first flow channel 12.

As shown in fig. 3, the second mixing section 20 includes a first sub-arc-shaped flow passage 24 and a second sub-arc-shaped flow passage 25. The first sub-arc-shaped flow channel 24 is provided with at least one second flow channel 22, the second sub-arc-shaped flow channel 25 is opposite to and communicated with the first sub-arc-shaped flow channel 24, the second sub-arc-shaped flow channel 25 is provided with at least one second flow channel 22, and the middle part of the second sub-arc-shaped flow channel 25 is provided with a fan-shaped expanding section 26. Thus, the structure of the second mixing part 20 is simpler, the processing and implementation are easy, and the processing cost and difficulty of the second mixing part 20 are reduced. At the same time, the fan-shaped expanding section 26 can avoid the medium from being blocked in the microfluidic mixing structure to influence the flow fluency of the medium.

In this embodiment, the initial part of the second mixing part 20 is a single flow channel, and then split into two flow channels, and then converged into a single flow channel.

It should be noted that the number of the second flow passages 22 is not limited thereto, and may be adjusted according to the working conditions and the use requirements. Alternatively, the number of second flow channels 22 is 3, or 4, or 5, or more.

The present application also provides a microfluidic chip device (not shown), including the microfluidic mixing structure described above, so that multiple fluids in the microfluidic chip can be sufficiently and uniformly mixed by the microfluidic mixing structure described above. And the real-time monitoring device with the mixing effect is used as an accessory of the micro-fluidic chip, so that the real-time monitoring, evaluation and online adjustment of the mixing intensity are realized.

Optionally, the microfluidic chip device further comprises a real-time monitoring device, and the mixing condition of the liquid in the chip is monitored in real time by using the tracer molecules and the real-time monitoring device.

In this embodiment, the real-time monitoring device selects at least one of the first liquid passing port 11, the second liquid passing port 13, the third liquid passing port 21 and the fourth liquid passing port 23 as the real-time monitoring sampling area.

In this embodiment, the real-time monitoring device selects small fluorescent molecules dissolved in the liquid as the labeling molecules, and selects a fluorescent inverted microscope as the detection device.

In this embodiment, the real-time monitoring device uses a computer to read fluorescence intensity data from the detection device, uses a computer program to automatically process the data, and determines and outputs the mixing effect in real time.

Specifically, a specific position in the mixing pipeline is selected as a detection window; selecting fluorescent dye molecules which are soluble in liquid as tracer molecules; selecting a microscope and a microscope camera as a data collecting device; the selected computer is a data processing device, and the selected program automatic processing method is a data processing method.

From the above description, it can be seen that the above embodiments of the present utility model achieve the following technical effects:

the microfluidic mixing structure comprises a first mixing part and a second mixing part, wherein the first mixing part is provided with a first liquid passing port, a first flow passage and a second liquid passing port, and the first liquid passing port is communicated with the second liquid passing port through the first flow passage. The second mixing part is provided with a third liquid passing port, at least two second flow passages and a fourth liquid passing port, the at least two second flow passages are oppositely arranged, and the third liquid passing port is communicated with the fourth liquid passing port through each second flow passage. The second liquid passing port of one first mixing part is communicated with the third liquid passing port of at least one second mixing part to form a first mixing unit, the second liquid passing port of one first mixing part is communicated with the first liquid passing port of at least one other first mixing part to form a second mixing unit, the fourth liquid passing port of one second mixing part is communicated with the first liquid passing port of at least one first mixing part to form a third mixing unit, and the fourth liquid passing port of one second mixing part is communicated with the third liquid passing port of at least one other second mixing part to form a fourth mixing unit. In this way, one first mixing unit may be selectively in communication with the other first, second, third and fourth mixing units; and/or one second mixing unit may be in selective communication with another second mixing unit, a third mixing unit, and a fourth mixing unit; and/or, one third mixing unit can be selectively communicated with the other third mixing unit and the fourth mixing unit; and/or one fourth mixing unit can be selectively communicated with the other fourth mixing unit, so that the microfluidic mixing structure has a combination mode of a plurality of mixing units, the problem of lower mixing effect of connection of a plurality of identical microfluidic mixing units in the prior art is solved, and the mixing effect and mixing uniformity of the microfluidic mixing structure are improved.

It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of example embodiments in accordance with the present application. As used herein, the singular is also intended to include the plural unless the context clearly indicates otherwise, and furthermore, it is to be understood that the terms "comprises" and/or "comprising" when used in this specification are taken to specify the presence of stated features, steps, operations, devices, components, and/or combinations thereof.

The relative arrangement of the components and steps, numerical expressions and numerical values set forth in these embodiments do not limit the scope of the present utility model unless it is specifically stated otherwise. Meanwhile, it should be understood that the sizes of the respective parts shown in the drawings are not drawn in actual scale for convenience of description. Techniques, methods, and apparatus known to one of ordinary skill in the relevant art may not be discussed in detail, but should be considered part of the specification where appropriate. In all examples shown and discussed herein, any specific values should be construed as merely illustrative, and not a limitation. Thus, other examples of the exemplary embodiments may have different values. It should be noted that: like reference numerals and letters denote like items in the following figures, and thus once an item is defined in one figure, no further discussion thereof is necessary in subsequent figures.

In the description of the present utility model, it should be understood that the azimuth or positional relationships indicated by the azimuth terms such as "front, rear, upper, lower, left, right", "lateral, vertical, horizontal", and "top, bottom", etc., are generally based on the azimuth or positional relationships shown in the drawings, merely to facilitate description of the present utility model and simplify the description, and these azimuth terms do not indicate and imply that the apparatus or elements referred to must have a specific azimuth or be constructed and operated in a specific azimuth, and thus should not be construed as limiting the scope of protection of the present utility model; the orientation word "inner and outer" refers to inner and outer relative to the contour of the respective component itself.

Spatially relative terms, such as "above … …," "above … …," "upper surface at … …," "above," and the like, may be used herein for ease of description to describe one device or feature's spatial location relative to another device or feature as illustrated in the figures. It will be understood that the spatially relative terms are intended to encompass different orientations in use or operation in addition to the orientation depicted in the figures. For example, if the device in the figures is turned over, elements described as "above" or "over" other devices or structures would then be oriented "below" or "beneath" the other devices or structures. Thus, the exemplary term "above … …" may include both orientations of "above … …" and "below … …". The device may also be positioned in other different ways (rotated 90 degrees or at other orientations) and the spatially relative descriptors used herein interpreted accordingly.

The above description is only of the preferred embodiments of the present utility model and is not intended to limit the present utility model, but various modifications and variations can be made to the present utility model by those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present utility model should be included in the protection scope of the present utility model.

Claims (13)

1. A microfluidic hybrid structure, comprising:

a first mixing part (10) provided with a first liquid passing port (11), a first flow channel (12) and a second liquid passing port (13), wherein the first liquid passing port (11) and the second liquid passing port (13) are communicated with the first flow channel (12);

a second mixing part (20) having a third liquid passing port (21), at least two second flow passages (22) and a fourth liquid passing port (23), wherein the at least two second flow passages (22) are arranged opposite to each other, and the third liquid passing port (21) is communicated with the fourth liquid passing port (23) through each second flow passage (22);

wherein the second liquid passing port (13) of one first mixing part (10) is communicated with the third liquid passing port (21) of at least one second mixing part (20) to form a first mixing unit, the second liquid passing port (13) of one first mixing part (10) is communicated with the first liquid passing port (11) of at least one other first mixing part (10) to form a second mixing unit, the fourth liquid passing port (23) of one second mixing part (20) is communicated with the first liquid passing port (11) of at least one first mixing part (10) to form a third mixing unit, and the fourth liquid passing port (23) of one second mixing part (20) is communicated with the third liquid passing port (21) of at least one other second mixing part (20) to form a fourth mixing unit;

one of the first mixing units is selectively communicable with the other of the first mixing unit, the second mixing unit, the third mixing unit, and the fourth mixing unit; and/or the number of the groups of groups,

one of the second mixing units may be selectively in communication with the other of the second mixing unit, the third mixing unit, and the fourth mixing unit; and/or the number of the groups of groups,

one of the third mixing units is selectively communicated with the other of the third mixing units and the fourth mixing unit; and/or the number of the groups of groups,

one of the fourth mixing units may be selectively in communication with another of the fourth mixing units;

the second mixing section (20) includes:

a first sub-arcuate flow path (24) having at least one of said second flow paths (22);

the second sub-arc-shaped flow passage (25) is arranged opposite to and communicated with the first sub-arc-shaped flow passage (24), the second sub-arc-shaped flow passage (25) is provided with at least one second flow passage (22), and the middle part of the second sub-arc-shaped flow passage (25) is provided with a fan-shaped expanding section (26).

2. The microfluidic mixing structure of claim 1, further comprising:

a first communicating portion (30), wherein the first communicating portion (30) has a first liquid passing channel, and a second liquid passing port (13) of one first mixing portion (10) is communicated with a first liquid passing port (11) of the other first mixing portion (10) through the first liquid passing channel; or the second liquid passing port (13) is communicated with the third liquid passing port (21) through the first liquid passing channel; or, the fourth liquid passing port (23) of one second mixing part (20) is communicated with the third liquid passing port (21) of the other second mixing part (20) through the first liquid passing channel; or the fourth liquid passing port (23) is communicated with the first liquid passing port (11) through the first liquid passing channel.

3. The microfluidic mixing structure of claim 1, further comprising:

a second communication part (40), wherein the second communication part (40) is provided with at least two second liquid passing channels, and the second liquid passing port (13) is communicated with at least two third liquid passing ports (21) through at least two second liquid passing channels; or the second liquid passing port (13) of one first mixing part (10) is communicated with the first liquid passing ports (11) of at least two other first mixing parts (10) through at least two second liquid passing channels; or the fourth liquid passing port (23) is communicated with at least two first liquid passing ports (11) through at least two second liquid passing channels; or, the fourth liquid passing port (23) of one second mixing part (20) is communicated with the third liquid passing ports (21) of at least two other second mixing parts (20) through at least two second liquid passing channels;

at least two second liquid passing channels are mutually connected in parallel.

4. The microfluidic mixing structure according to claim 1, wherein the first mixing section (10) comprises:

and the first runner (12) of the first sub-mixing part (14) is in a zigzag shape.

5. The microfluidic mixing structure according to claim 4, wherein the first runner (12) of the first sub-mixing part (14) comprises a first sub-runner (141), a second sub-runner (142) and a third sub-runner (143) which are bent and communicated in sequence, the first sub-runner (141) and the third sub-runner (143) are arranged opposite to each other, and the first sub-runner (141) and the third sub-runner (143) are located on the same side of the second sub-runner (142).

6. The microfluidic mixing structure according to claim 5, wherein the first sub-flow channel (141) comprises a first flow channel section (1411) and a second flow channel section (1412) which are sequentially bent and communicated, one end of the first flow channel section (1411) away from the second flow channel section (1412) is the first liquid passing port (11), and the first flow channel section (1411) and the second sub-flow channel (142) are respectively located at two sides of the second flow channel section (1412); and/or, the third sub-runner (143) comprises a third runner section (1431) and a fourth runner section (1432) which are bent and communicated in sequence, one end, away from the third runner section (1431), of the fourth runner section (1432) is the second liquid passing port (13), and the fourth runner section (1432) and the second sub-runner (142) are respectively positioned at two sides of the third runner section (1431).

7. The microfluidic mixing structure according to claim 1, wherein the first mixing section (10) further comprises:

and the first runner (12) of the second sub-mixing part (15) is arc-shaped.

8. The microfluidic mixing structure according to claim 7, wherein the first flow channel (12) of the second sub-mixing portion (15) comprises a fourth sub-flow channel (151), a fifth sub-flow channel (152) and a sixth sub-flow channel (153) which are sequentially bent and communicated, the fourth sub-flow channel (151) and the sixth sub-flow channel (153) are oppositely arranged, and the fourth sub-flow channel (151) and the sixth sub-flow channel (153) are both located on the same side of the fifth sub-flow channel (152).

9. A microfluidic chip device comprising a microfluidic mixing structure according to any one of claims 1 to 8.

10. The microfluidic chip device according to claim 9, further comprising a real-time monitoring device for monitoring the mixing of the liquid in the chip in real time using the tracer molecules and the real-time monitoring device.

11. The microfluidic chip device according to claim 10, wherein the real-time monitoring device selects at least one of the first liquid passing port (11), the second liquid passing port (13), the third liquid passing port (21) and the fourth liquid passing port (23) as a real-time monitoring sampling area.

12. The microfluidic chip device according to claim 10, wherein the real-time monitoring device selects fluorescent small molecules dissolved in the liquid as the labeling molecules and selects a fluorescent inverted microscope as the detection device.

13. The microfluidic chip device according to claim 10, wherein the real-time monitoring device reads fluorescence intensity data from the detection device using a computer, automatically processes the data using a computer program, and determines and outputs the mixing effect in real time.