CN109289035A - Reduce the cordyceps sinensis albumen peptide complexes of chemicotherapy side effect - Google Patents
Reduce the cordyceps sinensis albumen peptide complexes of chemicotherapy side effect Download PDFInfo
- Publication number
- CN109289035A CN109289035A CN201810832840.2A CN201810832840A CN109289035A CN 109289035 A CN109289035 A CN 109289035A CN 201810832840 A CN201810832840 A CN 201810832840A CN 109289035 A CN109289035 A CN 109289035A
- Authority
- CN
- China
- Prior art keywords
- cordyceps sinensis
- cordyceps
- side effect
- polysaccharide
- peptide complexes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/066—Clavicipitaceae
- A61K36/068—Cordyceps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8994—Coix (Job's tears)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
- A61K38/011—Hydrolysed proteins; Derivatives thereof from plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
- A61K38/012—Hydrolysed proteins; Derivatives thereof from animals
- A61K38/018—Hydrolysed proteins; Derivatives thereof from animals from milk
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Medical Informatics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
- Zoology (AREA)
Abstract
The invention belongs to pharmaceutical technology fields, it include the ingredient of following weight ratio: Cordyceps sinensis polysaccharide compound 35-55%, soy peptide powder 15-25%, lactalbumin 15-25%, coixan 7-13% more particularly to cordyceps sinensis albumen peptide complexes described in a kind of cordyceps sinensis albumen peptide complexes for reducing chemicotherapy side effect, surplus is medical or health care of food auxiliary material.The present invention more preferably plays the drug effect of Cordyceps sinensis polysaccharide compound by the raw materials such as compatibility Soyprotein peptide, while further through the particularity of Cordyceps sinensis polysaccharide compound, realization lactalbumin, and Soyprotein peptide and coixan effect further enhance;With Cordyceps sinensis polysaccharide compound compatibility Soyprotein peptide, coixan repairs the function of human body damaged cell to reach the side effect for reducing radiotherapy and chemotherapy medicine to human body.And the present invention uses the raw material of integration of drinking and medicinal herbs, using security level highest, it can the foodstuff raw material for not limiting dosage carries out reasonable compatibility, has both effect and safety, without side-effects, and without dose limit.
Description
Technical field
The invention belongs to pharmaceutical technology fields, and in particular to a kind of cordyceps sinensis protein peptides for reducing chemicotherapy side effect are compound
Object.
Background technique
Cordyceps sinensis polysaccharide contained in cordyceps sinensis is that cordyceps sinensis in-vivo content is most abundant, one of most important bioactive substance,
With extensive pharmacological action.Resource increasingly failure in recent years, people attempt culture cordyceps mycelia, fructification makees natural cs
Substitution, obtained different degrees of approval.First class national new drug cordyceps are to use to isolate from natural cs
Cordyceps species, the fermentation of artificial medium body and solid culture are made.
Cordyceps militaris is Ascomycota, meat seat mesh, cordyceps sinensis Cordycepps, the type sepecies of Cordyceps also known as northern Chinese caterpillar Fungus, northern worm
Grass etc..Cordyceps militaris has realized artificial cultivation at present.Cordycepin, cordycepic acid and Cordyceps sinensis polysaccharide compound are that aweto is peculiar
Substance, be the main indicator of cordyceps sinensis special efficacy.And exactly these indexs, it is raw under the conditions of artificial environment is affluent
Long northern Chinese caterpillar Fungus content can be grown higher than life under natural endowment.Protein, the ammonia for the northern Chinese caterpillar Fungus manually cultivated
Base acid, vitamin equal size meet or exceed the level of natural cordyceps.Although in the northern Chinese caterpillar Fungus manually cultivated
Individual nutritional ingredients be slightly below natural cordyceps level, but these nutritional ingredients can by research be improved.
As cordyceps sinensis tradition effect is constantly excavated, the especially corresponding pharmacological research of cordyceps sinensis composition and clinical efficacy fruit
The affirmative for all having obtained consumer as the drug of raw material and is protected food, health care product is gradually developed and enters market using cordyceps sinensis.Root
According to State Food and Drug Administration's data query as a result, domestic health-care food contg. Chinese caterpillar fungus is largely former grass or cultivation worm
Careless direct marketing, or carry out playing the roughing such as powder, tabletting sale, two are supplied with health food made of simple cordyceps sinensis
Drawback.
One to allow for cordyceps sinensis expensive, and single-item reaches that effect same day taking dose is larger, and product price is higher,
And ordinary consumer is enabled to be difficult to bear;
Second is that being not based on Basic Theories of Chinese Medicine, its maximum efficiency is played by Chinese medicine monarch, minister compatibility, and imitates health care
It can more protrude.
It is mostly sold currently on the market with simple cordyceps sinensis fresh grass, hay raw material, cordyceps sinensis deep processed product kind analogy
Few compared with single and quantity, cordyceps sinensis composition market is largely moved towards based on high-end medical product, seriously constrains the attached of cordyceps sinensis combination
Price markup value and economic benefit.And existing cordyceps sinensis beverage formulation production technology is not reasonable, so that active constituent is destroyed, nutrition
Material damage is excessive, and unbalanced nutrition, health-care effect are unobvious;In addition excessive auxiliary material, such as sugarcane are added in process of producing product
Sugar, preservative, artificial color etc. damage consumer's health, are unable to satisfy the demand of consumer's nourishing and health preserving.
In addition, the treatment of malignant tumour has been made significant headway in recent years, it is largely due to Radiotherapy chemotherapy
It is gradually perfect.But the adverse reactions such as gastrointestinal reaction, bone marrow suppression, immunity counteracting, drug resistance that Radiotherapy chemotherapy easily occurs, sternly
The quality of life of patient is affected again, also influences the clinical application of Radiotherapy chemotherapy to a certain extent.Thus research is clearly fought
The drug of side reaction is a problem to be solved after Radiotherapy chemotherapy.
Summary of the invention
The present invention is in view of the above-mentioned problems, propose a kind of Cordyceps sinensis polysaccharide compound, Soyprotein peptide, lactalbumin and the heart of a lotus seed
The compatibility of seed of jog's tears polysaccharide, to solve the defect of prior art worm grass product, reaching with Cordyceps sinensis polysaccharide compound is that monarch part is main
It leads, Soyprotein peptide is that minister part paving helps, is equipped with lactalbumin, coixan is composed, synergistic, kidney-tonifying sperm-generating, increasing
The purpose of strong man's body renal function.
The technical solution adopted by the present invention is as follows:
The present invention provide it is a kind of reduce chemicotherapy side effect cordyceps sinensis albumen peptide complexes, including following weight ratio at
Point:
Cordyceps sinensis polysaccharide compound 35-55%, soy peptide powder 15-25%, lactalbumin 15-25%, coixan 7-
13%, surplus is medical or health care of food auxiliary material,
The Cordyceps sinensis polysaccharide compound includes Cordyceps sinensis polysaccharide and cordyceps sinensis basic ingredient, wherein the cordyceps sinensis basic ingredient selects
From one of following:
The extract or concentrate of cordyceps sinensis powder or fermented cordyceps hypha body;
Wherein cordyceps sinensis is Cordyceps sinensis fungus parasitism and the fungus combination that can generate fructification, including cordyceps sinensis, pupa worm
Other kinds of grass and Cordyceps.
Further, the cordyceps sinensis is Cordyceps militaris.
Further, polysaccharide or liquid fermentation and culture cordyceps mycelium that the Cordyceps sinensis polysaccharide utilizes Cordyceps militaris to extract,
Then Cordyceps sinensis polysaccharide is extracted from fermentation liquid to be purified.
Further, the mass fraction of Cordyceps sinensis polysaccharide is 20%-35% in the Cordyceps sinensis polysaccharide compound.
Further, the cordyceps sinensis protein peptides piece for reducing chemicotherapy side effect is by following weight ratio at being grouped as: cordyceps sinensis
Polysaccharide compound 50%, soy peptide powder 20%, lactalbumin 20%, coixan 10%.
Further, the mass fraction of Cordyceps sinensis polysaccharide is 30% in the Cordyceps sinensis polysaccharide compound.
Further, tablet is made in the cordyceps sinensis albumen peptide complexes.
Compared with prior art, the beneficial effects of the present invention are:
The present invention using Cordyceps sinensis polysaccharide compound be that monarch part is leading, Soyprotein peptide is helped as minister part paving, be equipped with lactalbumin,
Coixan is composed, synergistic, and the effective component contained by cordyceps sinensis realizes the collaboration effect of the two as formula basis
Fruit.Repetition value in cordyceps sinensis effective component basic components plus the compound prescription of high-content polysaccharide is the disease to human body
It prevents, treats, more accurate, more efficient, more reasonable and equilibrium of promoting longevity.Pure polysaccharide high-content is also far away in practice
Reach above-mentioned target, and inventor reaches the cordyceps sinensis basis of highest threshold values effectively by studying and practicing discovery for many years
When composition (or enriched basic effective ingredient) mixes high-content polysaccharide to the preventing, treating of human diseases, promoting longevity reaches
Optimum efficiency.
And human body can be enhanced to the assimilation effect of other substances, to promote other compositions in Cordyceps sinensis polysaccharide compound
The effect of.
Soyprotein peptide, at home and abroad research quickly recover from fatigue it has been confirmed that having, enhance muscle strength, promote energy
Amount metabolism and weight-reducing, alleviate after drinking sense of discomfort, slow down stress improve attention, norcholesterol, hypoglycemic, blood pressure lowering, drop
The healthy functions such as blood lipid, enhancing immunocompetence, are known as " super amino acid ".
Semen coicis thinks that its property slightly sweet flavor is slightly cold as Chinese medicine, Chinese medicine, have invigorating the spleen, dry, except wind, clearing away heat and eliminating pus, remove
Numbness analgesic, the drug with tonifying spleen effect can heighten the effect of a treatment by bran stir-fry, mitigate the fierce medicine property of medicine of certain effects.It extracts
Coixan afterwards has the function of mitigating injury of the radiotherapy and chemotherapy medicine to human body.
Lactalbumin can also stimulate human immune system, prevent the generation of chemically induced property cancer, while it is strong to increase bone
Degree and reduction LDL cholesterol are horizontal.
The present invention more preferably plays the drug effect of Cordyceps sinensis polysaccharide compound by raw materials such as compatibility Soyprotein peptides, while leading to again
The particularity of Cordyceps sinensis polysaccharide compound is crossed, realizes lactalbumin, the further increasing of Soyprotein peptide and coixan effect
By force;With Cordyceps sinensis polysaccharide compound compatibility Soyprotein peptide, coixan is to reach the pair work for reducing radiotherapy and chemotherapy medicine to human body
With the function of reparation human body damaged cell.And the present invention uses the raw material of integration of drinking and medicinal herbs, using security level highest
Reasonable compatibility is carried out not limit the foodstuff raw material of dosage, has both effect and safety, it is without side-effects, and without dose limit.
Specific embodiment:
Combined with specific embodiments below, the present invention will be described in detail.
Embodiment 1
Reduce the cordyceps sinensis protein peptides piece of chemicotherapy side effect
Cordyceps mycelia is taken, liquid fermentation method is cultivated, and after culture 5 days, is extracted the Cordyceps sinensis polysaccharide in culture, is mentioned
It takes method using the prior art, obtains cordyceps sinensis Thick many candies.Then cordyceps sinensis Thick many candies are purified, obtains purity and is greater than
90% Cordyceps sinensis polysaccharide.
Another insect-taking grass Mycelium culture is concentrated, and obtains cordyceps sinensis culture solution concentrate after 10 times of concentration, and by weight hundred
Score, 30% Cordyceps sinensis polysaccharide, 70% cordyceps sinensis culture solution concentrate configure Cordyceps sinensis polysaccharide compound.
Coixan is extracted using water extraction and alcohol precipitation method, and purity is greater than 95% after extraction.
The cordyceps sinensis protein peptides piece for reducing chemicotherapy side effect is configured by following mass fraction:
Cordyceps sinensis polysaccharide compound 50%, soy peptide powder 25%, lactalbumin 15%, coixan 10%, are reduced
The cordyceps sinensis protein peptides piece of chemicotherapy side effect.
It is demonstrated experimentally that the curative effect of the cordyceps sinensis protein peptides piece of the reduction chemicotherapy side effect of the present embodiment is remote under equal conditions
Super individual Cordyceps sinensis polysaccharide compound, individual Soyprotein peptide and individual coixan.
Embodiment 2
Reduce the cordyceps sinensis protein peptides piece of chemicotherapy side effect
Cordyceps mycelia is taken, liquid fermentation method is cultivated, and after culture 6 days, is extracted the Cordyceps sinensis polysaccharide in culture, is mentioned
It takes method using the prior art, obtains cordyceps sinensis Thick many candies.Then cordyceps sinensis Thick many candies are purified, obtains purity and is greater than
95% Cordyceps sinensis polysaccharide.
Another insect-taking grass Mycelium culture is concentrated, and obtains cordyceps sinensis culture solution concentrate after 15 times of concentration, and by weight hundred
Score, 30% Cordyceps sinensis polysaccharide, 70% cordyceps sinensis culture solution concentrate configure Cordyceps sinensis polysaccharide compound.
Coixan is purchased from market, (Lanzhou water Lai Si Biotechnology Co., Ltd), and purity is greater than 95%.
The cordyceps sinensis protein peptides piece for reducing chemicotherapy side effect is configured by following mass fraction:
Cordyceps sinensis polysaccharide compound 55%, soy peptide powder 15%, lactalbumin 15%, coixan 13%, maltodextrin
2%, it is reduced the cordyceps sinensis protein peptides piece of chemicotherapy side effect.
It is demonstrated experimentally that the curative effect of the cordyceps sinensis protein peptides piece of the reduction chemicotherapy side effect of the present embodiment is remote under equal conditions
Super individual Cordyceps sinensis polysaccharide compound and individual Soyprotein peptide.
Embodiment 3
Reduce the cordyceps sinensis protein peptides piece of chemicotherapy side effect
Cordyceps mycelium is taken, liquid fermentation method is cultivated, after culture 8 days, the Cordyceps sinensis polysaccharide in culture is extracted,
Extracting method uses the prior art.The present embodiment selection is extracted with water extraction, obtains cordyceps sinensis Thick many candies.Then to cordyceps sinensis
Thick many candies are purified, and the Cordyceps sinensis polysaccharide that purity is greater than 95% is obtained.
Separately cordyceps mycelium culture is taken to be concentrated, obtains cordyceps sinensis culture solution concentrate after 10 times of concentration, by weight
Percentage, 25% Cordyceps sinensis polysaccharide, 75% cordyceps sinensis culture solution concentrate configure Cordyceps sinensis polysaccharide compound.
Coixan is extracted using water extraction and alcohol precipitation method, and purity is greater than 95% after extraction.It configures and drops by following mass fraction
The cordyceps sinensis protein peptides piece of low chemicotherapy side effect:
Cordyceps sinensis polysaccharide compound 50%, soy peptide powder 20%, lactalbumin 20%, coixan 10%, are reduced
The cordyceps sinensis protein peptides piece of chemicotherapy side effect.
It is demonstrated experimentally that the curative effect of the cordyceps sinensis protein peptides piece of the reduction chemicotherapy side effect of the present embodiment is remote under equal conditions
Super individual Cordyceps sinensis polysaccharide compound and individual cordyceps sinensis basic ingredient.
Embodiment 4
Reduce the cordyceps sinensis protein peptides piece of chemicotherapy side effect
Cordyceps mycelium is taken, liquid fermentation method is cultivated, after culture 10 days, the Cordyceps sinensis polysaccharide in culture is extracted,
Extracting method uses the prior art.The present embodiment selection is extracted with water extraction, obtains cordyceps sinensis Thick many candies.Then to cordyceps sinensis
Thick many candies are purified, and it is multiple to obtain Cordyceps sinensis polysaccharide of the purity greater than 99%.
Separately cordyceps mycelium culture is taken to be concentrated, obtains cordyceps sinensis culture solution concentrate after 10 times of concentration, by weight
Percentage, 35% Cordyceps sinensis polysaccharide, 65% cordyceps sinensis culture solution concentrate configure Cordyceps sinensis polysaccharide compound.
Coixan is purchased from market, (Lanzhou water Lai Si Biotechnology Co., Ltd), and purity is greater than 95%.
The cordyceps sinensis protein peptides piece for reducing chemicotherapy side effect is configured by following mass fraction:
Cordyceps sinensis polysaccharide compound 37%, soy peptide powder 25%, lactalbumin 25%, coixan 13%.It is pressed after preparation
Tablet is made in piece.
It is demonstrated experimentally that the curative effect of the cordyceps sinensis protein peptides piece of the reduction chemicotherapy side effect of the present embodiment is remote under equal conditions
Super individual Cordyceps sinensis polysaccharide compound and individual cordyceps sinensis basic ingredient.
Embodiment 5
Reduce the cordyceps sinensis protein peptides piece of chemicotherapy side effect
Cordyceps mycelium is taken, liquid fermentation method is cultivated, after culture 10 days, the Cordyceps sinensis polysaccharide in culture is extracted,
Extracting method uses the prior art.The present embodiment selection is extracted with water extraction, obtains cordyceps sinensis Thick many candies.Then to cordyceps sinensis
Thick many candies are purified, and it is multiple to obtain Cordyceps sinensis polysaccharide of the purity greater than 99%.
Separately cordyceps mycelium culture is taken to be concentrated, obtains cordyceps sinensis culture solution concentrate after 10 times of concentration, by weight
Percentage, 30% Cordyceps sinensis polysaccharide, 70% cordyceps sinensis culture solution concentrate configure Cordyceps sinensis polysaccharide compound.
Coixan is purchased from market, (Lanzhou water Lai Si Biotechnology Co., Ltd), and purity is greater than 95%.
The cordyceps sinensis protein peptides piece for reducing chemicotherapy side effect is configured by following mass fraction:
Cordyceps sinensis polysaccharide compound 50%, soy peptide powder 20%, lactalbumin 20%, coixan 10%.It is pressed after preparation
Tablet, specification 0.2g/ piece is made in piece.
Embodiment 6
Reduce the cordyceps sinensis protein peptides piece of chemicotherapy side effect
Cordyceps mycelium is taken, liquid fermentation method is cultivated, after culture 10 days, the Cordyceps sinensis polysaccharide in culture is extracted,
Extracting method uses the prior art.The present embodiment selection is extracted with water extraction, obtains cordyceps sinensis Thick many candies.Then to cordyceps sinensis
Thick many candies are purified, and it is multiple to obtain Cordyceps sinensis polysaccharide of the purity greater than 99%.
Separately cordyceps mycelium culture is taken to be concentrated, obtains cordyceps sinensis culture solution concentrate after 10 times of concentration, by weight
Percentage, 30% Cordyceps sinensis polysaccharide, 70% cordyceps sinensis culture solution concentrate configure Cordyceps sinensis polysaccharide compound.
Coixan is purchased from market, (Lanzhou water Lai Si Biotechnology Co., Ltd), and purity is greater than 95%.
The cordyceps sinensis protein peptides piece for reducing chemicotherapy side effect is configured by following mass fraction:
Cordyceps sinensis polysaccharide compound 60%, soy peptide powder 15%, lactalbumin 15%, coixan 10%.It is pressed after preparation
Tablet, specification 0.2g/ piece is made in piece.
Embodiment 7: cordyceps sinensis protein peptides piece reduces chemicotherapy side effect mouse test
(1) cordyceps sinensis protein peptides piece tests Treated with Chemotherapy with Cyclophosphamide mouse side effects
Test apparatus: UV3600 type spectrophotometer (Japanese Shimadzu Co., Ltd);Microscope CX31-72C02 2400
(Olympus).
Test drug: cordyceps sinensis albumen peptide complexes used in testing are the cordyceps sinensis protein peptides that embodiment 1-6 is prepared
Piece, specification are 0.2g/ piece, and the sample that embodiment 1-6 is obtained successively is named as sample 1-6, and when test is matched with physiological saline
System, chemotherapy test drug use cyclophosphamide (Jiangsu Sheng Di Pharmaceuticals Ltd, 0.1g/ branch), Diyushengbai Tablet (Chengdu
Group self-sufficient and strategically located region medicine company limited liability company difficult to understand, 0.1g/ piece).
Animal and tumor strain: ICR kind healthy mice 80, weight 18-22g, half male and half female is moved by Zhejiang University of Traditional Chinese Medicine
Object experimental study center provides, and uses after laboratory rearing 3d.
Statistical method: data withIt indicates, is examined with t between group and carry out statistical analysis.
Test method and result: taking mouse 40, and half male and half female is divided into 10 groups, every group 4 (half male and half female), removes physiology
Outside saline control group, the equal intraperitoneal injection of cyclophosphamide 100mg/kg of remaining control group (abbreviation ring), continuous 2d.Each dosage simultaneously
Group is administered once daily, each 250mg/kg, successive administration 7d, and eyeball is taken a blood sample after last dose 1h, separates serum, measurement
Blood routine and Liver and kidney function the results are shown in Table 1 and 2.
1 test sample of table causes the influence of poisoning mice blood routine variation to cyclophosphamide
Note: the Cordyceps sinensis polysaccharide that Cordyceps sinensis polysaccharide compound is 30% in table 1,70% cordyceps sinensis culture solution concentrate configure worm
Grass polysaccharide compound.
The * P < 0.01 compared with cyclophosphamide+saline control group, the * * P < 0.01 compared with saline control.
2 test sample of table causes the influence of poisoning mice Liver and kidney function variation to cyclophosphamide
The * P < 0.05 compared with cyclophosphamide+saline control.
The result shows that cyclophosphamide can obviously reduce mouse peripheral leukocytes, at this dose to Liver and kidney function and
Peripheral Erythrocytes, which have no, to be significantly affected;Cordyceps sinensis protein peptides piece of the invention increases obviously, with cyclophosphamide salt water leukocyte count
Control group relatively has significant difference.Show that sample 1-5 of the invention can fight cyclophosphamide and reduce the effect of leucocyte.
(2) cordyceps sinensis protein peptides piece tests radiotherapy chemotherapy mouse side effects
Test method and result: taking mouse 40, and half male and half female is randomly divided into 10 groups, and every group 4, half male and half female is removed
Outside saline control group, the full-body exposure of groups of animals Co- gamma-rays 1 time (metering 623cGy).Hereafter each dosage group, daily
Be administered once, each 250mg/kg, successive administration 7d, after last dose 1h eyeball take a blood sample, separate serum, measure blood routine and
Liver and kidney function the results are shown in Table 3 and 4.
The influence that 3 test sample of table changes radiotherapy poisoning mice blood routine
The * P < 0.01 compared with cyclophosphamide+saline control group, the * * P < 0.01 compared with saline control.
4 test sample of table causes the influence of poisoning mice Liver and kidney function variation to radiotherapy
The * P < 0.05 compared with radiotherapy+saline control, the * * P < 0.01 compared with saline control.
The result shows that can obviously reduce mouse peripheral leukocytes after radiotherapy, TP is apparently higher than Normal group, herein
Liver and kidney function and Peripheral Erythrocytes are had no under dosage and significantly affected;Radiotherapy+saline control group leukocyte count obviously rises
Height, each dosage group can significantly reduce the raising due to caused by radiotherapy, there is significant difference compared with combination radiotherapy group.Show the present invention
Cordyceps sinensis albumen peptide complexes have certain antagonism to the reduction of peripheral leukocytes after radiotherapy, and can fight due to radiotherapy
Caused TP is increased.
The above description is only a preferred embodiment of the present invention, not thereby limits scope of patent protection of the invention, all
It is directly or indirectly to be used in other related technical areas with equivalent structure transformation made by present specification,
It similarly include within the scope of the present invention.
Claims (7)
1. reducing the cordyceps sinensis albumen peptide complexes of chemicotherapy side effect, which is characterized in that the cordyceps sinensis albumen peptide complexes include
The ingredient of following weight ratio:
Cordyceps sinensis polysaccharide compound 35-55%, soy peptide powder 15-25%, lactalbumin 15-25%, coixan 7-13%, it is remaining
Amount is medical or health care of food auxiliary material,
The Cordyceps sinensis polysaccharide compound includes Cordyceps sinensis polysaccharide and cordyceps sinensis basic ingredient, wherein the cordyceps sinensis basic ingredient is selected from following
One of:
The extract or concentrate of cordyceps sinensis powder or fermented cordyceps hypha body;
Wherein cordyceps sinensis is that Cordyceps sinensis fungus is parasitic and can generate the fungus combination of fructification, including cordyceps sinensis, Cordyceps militaris and
Other kinds of Cordyceps.
2. reducing the cordyceps sinensis albumen peptide complexes of chemicotherapy side effect as described in claim 1, which is characterized in that the cordyceps sinensis
For Cordyceps militaris.
3. reducing the cordyceps sinensis albumen peptide complexes of chemicotherapy side effect as claimed in claim 2, which is characterized in that the cordyceps sinensis
Then it is more to extract cordyceps sinensis from fermentation liquid for the polysaccharide or liquid fermentation and culture cordyceps mycelium that polysaccharide utilizes Cordyceps militaris to extract
Sugar is purified.
4. reducing the cordyceps sinensis albumen peptide complexes of chemicotherapy side effect as claimed in claim 2, which is characterized in that the cordyceps sinensis
The mass fraction of Cordyceps sinensis polysaccharide is 20%-35% in polysaccharide compound.
5. reducing the cordyceps sinensis albumen peptide complexes of chemicotherapy side effect as described in claim 1, which is characterized in that the reduction
The cordyceps sinensis protein peptides piece of chemicotherapy side effect is by following weight ratio at being grouped as: Cordyceps sinensis polysaccharide compound 50%, soy peptide powder
20%, lactalbumin 20%, coixan 10%.
6. reducing the cordyceps sinensis albumen peptide complexes of chemicotherapy side effect as claimed in claim 5, which is characterized in that the cordyceps sinensis
The mass fraction of Cordyceps sinensis polysaccharide is 30% in polysaccharide compound.
7. the cordyceps sinensis albumen peptide complexes of reduction chemicotherapy side effect as claimed in any one of claims 1 to 6, feature exist
In tablet is made in the cordyceps sinensis albumen peptide complexes.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710647502 | 2017-08-01 | ||
CN2017106475027 | 2017-08-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN109289035A true CN109289035A (en) | 2019-02-01 |
Family
ID=65172286
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201810832840.2A Pending CN109289035A (en) | 2017-08-01 | 2018-07-26 | Reduce the cordyceps sinensis albumen peptide complexes of chemicotherapy side effect |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN109289035A (en) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105998908A (en) * | 2016-07-11 | 2016-10-12 | 李宗贤 | Chinese herba preparation for treating tumors and resisting toxic and side effects of chemotherapy and preparation method thereof |
CN106913854A (en) * | 2017-01-22 | 2017-07-04 | 楼良水 | Cordyceps sinensis polysaccharide albumen peptide complexes and its application |
CN106912953A (en) * | 2017-01-22 | 2017-07-04 | 楼良水 | Cordyceps sinensis polysaccharide compound and its application |
-
2018
- 2018-07-26 CN CN201810832840.2A patent/CN109289035A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105998908A (en) * | 2016-07-11 | 2016-10-12 | 李宗贤 | Chinese herba preparation for treating tumors and resisting toxic and side effects of chemotherapy and preparation method thereof |
CN106913854A (en) * | 2017-01-22 | 2017-07-04 | 楼良水 | Cordyceps sinensis polysaccharide albumen peptide complexes and its application |
CN106912953A (en) * | 2017-01-22 | 2017-07-04 | 楼良水 | Cordyceps sinensis polysaccharide compound and its application |
Non-Patent Citations (1)
Title |
---|
马文熙 等: "《抗衰老与健康》", 30 June 2014, 南京:东南大学出版社 * |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP2020172523A (en) | Eurycoma longifolia extract and its use in enhancing and/or stimulating immune system | |
CN106913854A (en) | Cordyceps sinensis polysaccharide albumen peptide complexes and its application | |
CN108144040A (en) | The cordyceps sinensis oyster peptide complexes of kidney-tonifying sperm-generating | |
CN103462022B (en) | Cordyceps militaris nourishing paste and preparation method thereof | |
CN108210878A (en) | The cordyceps sinensis Saussurea Polysaccharide compound of kidney-tonifying sperm-generating | |
CN102715614A (en) | Novel beverage containing black garlic | |
CN103564495B (en) | Propolis and cordycepic hypha powder composition, as well as preparation and application thereof | |
CN101856384A (en) | Liver-protecting combination | |
CN106236927A (en) | A kind of Chinese medicine composition with enhancing immunity and antifatigue effect and preparation method thereof and purposes | |
CN109043105A (en) | The cordyceps sinensis sea cucumber peptide pressed candy of kidney-tonifying sperm-generating | |
CN108477367A (en) | The cordyceps sinensis oligopeptide pressed candy of Soboring-up liver-protecting | |
CN104056054B (en) | The oral formulations of a kind of anti-oxidant and strengthen immunity and its preparation | |
CN102754834A (en) | Biological mixture for regulating emotion and relieving stress and preparation method thereof | |
CN108187032A (en) | Cordyceps sinensis collagen peptide piece | |
CN108148715A (en) | Cordyceps sinensis polysaccharide wine | |
CN103893101A (en) | Ganoderma lucidum and pollen anti-aging cream | |
CN109289035A (en) | Reduce the cordyceps sinensis albumen peptide complexes of chemicotherapy side effect | |
CN106937923A (en) | Lucid ganoderma-pollen skin care health care frost | |
CN108096570A (en) | Cordyceps sinensis protein peptides piece with toxin expelling weight losing function | |
CN101731624B (en) | Compound male silkworm moth health-care food for resisting senility and regulating immunity and preparation method | |
CN109077954A (en) | Cordyceps sinensis facial mask | |
CN108888750A (en) | Cordyceps sinensis pueraria lobata compound with function of blood sugar reduction | |
CN109349647A (en) | A kind of compound amino acid oral liquid and preparation method thereof based on intestines and stomach health-care | |
CN103238878B (en) | Oyster liquid beverage for enhancing immunity and preparation method of oyster liquid beverage | |
CN102631506B (en) | Traditional Chinese medicine composition capable of improving immunity and resisting fatigue |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190201 |
|
RJ01 | Rejection of invention patent application after publication |