CN109276499A - A kind of the natural plants hand cleanser and preparation method of preservative free - Google Patents
A kind of the natural plants hand cleanser and preparation method of preservative free Download PDFInfo
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- CN109276499A CN109276499A CN201811354303.8A CN201811354303A CN109276499A CN 109276499 A CN109276499 A CN 109276499A CN 201811354303 A CN201811354303 A CN 201811354303A CN 109276499 A CN109276499 A CN 109276499A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/26—Aluminium; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/70—Biological properties of the composition as a whole
- A61K2800/72—Hypo-allergenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
Abstract
The invention discloses the natural plants hand cleanser and preparation method of a kind of preservative free, which is poplar flower extract, radix macrotomiae immersion oil, tourmaline powder, plant amino acid；Wherein, poplar flower extract preparation: poplar flower is crushed, ethanol water is added by feed liquid weight ratio 1:5-20, it stirs evenly, ultrasonic extraction 1-3h, filtering and concentrating at 80-100 DEG C of temperature, 95% ethyl alcohol of 3-5 times of volume is added, 4 DEG C of refrigerator 24-48h are placed in, refrigerated centrifuge obtains poplar flower extract.Hand cleanser of the present invention reaches bactericidal and corrosion-resistant purpose using natural plants poplar flower extract, radix macrotomiae extract etc., without chemical substance preservative, the risk for not only avoiding sensitization caused by chemical preservative, disturbance endocrine even carcinogenic, and it is degradable, noresidue, it is harmless to human health and water environment；The present invention prepares hand cleanser using poplar flower extract for the first time, and waste utilization effectively improves economic benefit.
Description
Technical field
The present invention relates to daily chemical products technical fields, more particularly, to the natural plants hand cleanser and system of a kind of preservative free
Preparation Method.
Background technique
The abuse of chemical preservative in daily chemical products, damages people's skin and health.It is reported that making for a long time
With the daily chemical products containing MIT, CIT, user's skin allergy is easily caused；Triclosan, triclocarban, parabens chemicals
Matter preservative can also interfere human endocrine or even carcinogenic, cause damages to human health；In addition, the preservative after washing is useless
Water, it is not degradable, very big, unfavorable water environment protection is endangered to aquatile.
Contain many nutritional ingredients and antipathogenic composition in natural plants, the natural plants with restraining and sterilizing bacteria effect are used for
In daily chemical products, effect is good, degradable, not only contributes to human health, and be conducive to environmental protection, therefore, using natural
Plant replaces chemical preservative, is hot research direction.
Poplar, broad-leaved arbor, growth rapidly, are distributed extremely wide in China.Poplar flower contains Flavonoid substances, organic acid
Equal Multiple components have excellent bactericidal bacteriostasis, but the research and development that poplar flower is used as daily chemical products yet there are no report
Road, a large amount of poplar flower are turned into spring mud, cause the significant wastage of resource.
Tourmaline powder, also known as tourmaline powder, are a kind of borosilicate crystalline solid with energy, surface flow 0.06 milli
The micro-current of peace can emit the far infrared (wavelength in 4-14um) beneficial to human body, boost metabolism, and reduce heart pressure
Power.
The prior art such as Authorization Notice No. is the Chinese invention patent of 105078828 B of CN, discloses a kind of plants antimicrobial
Compound hand cleanser and preparation method thereof, the hand cleanser are mainly made of Rhizoma Gastrodiae, P-Cymene, radix scutellariae, frutus cnidii, kuh-seng etc., tool
There is significant antibacterial effect.But the plants antimicrobial compound hand cleanser has used more rare traditional Chinese medicine, it is at high cost.
Summary of the invention
The purpose of the present invention is to provide a kind of natural plants hand cleanser of preservative free, contain poplar flower, radix macrotomiae etc.
Antimicrobial natural antimicrobial component has durable antibiotic, dirt-removing functions, and has good moisture-keeping function.
It is a further object of the present invention to provide a kind of preparation methods of the natural plants hand cleanser of preservative free.
The present invention in view of the above technology in the problem of mentioning, the technical solution taken are as follows:
A kind of natural plants hand cleanser of preservative free, the raw material including following parts by weight: poplar flower extract 0.01-50
Part, preferably 0.1-40 parts, more preferably 1-20 parts, 0.5-30 parts, preferably 1-20 parts of oil of radix macrotomiae immersion；The present invention is for the first time
Poplar flower extract is used to prepare hand cleanser, poplar flower extract, radix macrotomiae, Sweet Almond Oil, plant ammonia in the hand cleanser
The various compositions such as base acid, tocopherol, hyaluronic acid are used cooperatively, and not only have anti-oxidant and lasting bacteriostasis efficacy, but also have
There is good moistening effect.
Poplar flower extract extraction includes: to crush poplar flower, and ethanol water is added by feed liquid weight ratio 1:5-20, stirs
It mixes uniformly, the ultrasonic extraction 1-3h at 80-100 DEG C of temperature, filtering and concentrating is added 95% ethyl alcohol of 3-5 times of volume, is placed in 4 DEG C
Refrigerator 24-48h, refrigerated centrifuge obtain poplar flower extract；Poplar flower extract contain flavones, organic acid, amino acid, carbohydrate and
Alkaloid isoreactivity ingredient has excellent bactericidal bacteriostasis, can directly press down the resistance killed pathogen, and improve body, adjusts
The immune function of body is saved, while supplementing amino acid to skin, prevents from having dry skin.
Preferably, in poplar flower extract extraction step, ethanol water concentration is 55-85%, preferably 70%；Second
For alcohol solution concentration lower than 55% and/or higher than 85%, extraction effect is bad.
Further preferably, in poplar flower extract extraction step, ultrasonic power 250w, frequency 40kHz；Ultrasonic wave has sky
Change effect can destroy plant tissue, and help discharges effective component, and ultrasonic frequency is lower, and cavitation is stronger, but to plant
Disorganization is also bigger, and the frequency of 40kHz is better than 20kHz, can achieve appropriateness and destroys plant tissue, effectively improves extraction
Rate, and be able to maintain the nutritional ingredient in poplar flower and be not destroyed.
Still more preferably, in poplar flower extract extraction step, the revolving speed of refrigerated centrifuge is 3000rpm, centrifuging temperature
It is 4 DEG C；4 DEG C of low-temperature centrifugations remove impurity, improve the hand cleanser of poplar flower extract preparation, still have height steady at low temperature
It is qualitative, it is not in lamination.
It includes: that radix macrotomiae root is crushed to 2-6cm that radix macrotomiae, which impregnates oil preparation, and sweet tea apricot is added by 4-6 times of feed liquid weight ratio
Benevolence oil, 60-80 DEG C of immersion 10-30d leach its effective component alkannin sufficiently, filter, and obtain radix macrotomiae and impregnate oil；Radix macrotomiae
Chemical component mainly includes alkannin and lithosperman, also contains phenolic acid class, alkaloids, monoterpene benzoquinones, two phenols of benzene, triterpene
Acid and a variety of active ingredients such as sterols, flavonoids have the effects that antitumor, bacteriostasis antibiosis, anti-inflammatory, antiviral；Dessert almond
Oil can be very good dissolution alkannin and other are soluble in the active constituent of grease, and radix macrotomiae is extracted with Sweet Almond Oil, is used for
Hand cleanser is prepared, that is, the moisturizing that the effects of antimicrobial antiphlogistic of the Asian puccoon efficiently used is antiviral efficiently uses Sweet Almond Oil again is mild
Anti-drying effect has cooperative gain effect.
A kind of natural plants hand cleanser of preservative free, hand cleanser raw material further include 0.5-5 parts of tourmaline powder, plant amino acid
0.5-15 parts；Wherein, tourmaline powder is preferably fiber tourmaline powder, and fineness is 200 mesh；Tourmaline powder is beneficial containing a variety of more human bodies
Minerals, surface flow 0.06 milliampere of micro-current, the far infrared of the 4-14um wavelength beneficial to human body can be emitted, promote
Metabolism；Using 200 mesh fineness, particle friction when washing has health care, decontamination and slight exfoliating effect, enhances
The beneficial effect of hand cleanser；Plant amino acid preferably guarantees the mild action of hand cleanser, non-stimulated to skin.
A kind of preparation method of the natural plants hand cleanser of preservative free, comprising: weigh poplar flower extract, soft in proportion
Asian puccoon impregnates oil, tourmaline powder, and olive oil, tocopherol, SDS, sodium chloride, deionized water is then added, and heats and stablizes to 60-70
DEG C, suspending agent, surfactant, stabilizer, thickener is added in stirring, stirs to after being completely dissolved, and is cooled to 40 DEG C, stirring
Plant amino acid, hyaluronic acid, emollient is added in 15-30min, adjusts pH to 5.5-6.8 using pH adjusting agent, stands, wait steep
Foam completely disappears, and liquid is transparent to obtain the final product.
Human skin is weakly acidic, and conventional cleaning product is all in alkalescent, and some pH value are even up to 10, has to skin
There is very strong stimulation, easily leads to allergy, and pH value is faintly acid by hand cleanser of the present invention, the acid of perfection fitting human skin
Alkalinity does not stimulate mildly.
Natural plants hand cleanser pH stable produced by the present invention, it is weakly acidic；Moisture retention is not less than 12%；To large intestine angstrom
Uncommon bacterium and staphylococcus aureus bacteriostasis rate are greater than 98%, are greater than to the bacteriostasis rate of Candida albicans and Bacillus paratyphosus B
95%.
Compared with the prior art, the advantages of the present invention are as follows:
1) hand cleanser of the present invention is free of chemical substance preservative, reduces skin irritation, it is entirely avoided chemical substance is anti-
The even carcinogenic risk of rotten agent bring sensitization, disturbance endocrine.
2) hand cleanser of the present invention reaches bactericidal using natural plants poplar flower extract, radix macrotomiae extract etc. and prevents
Rotten purpose, and the nutritional ingredient in plant extracts is remained, there is good antibacterial while so that product is had cleaning action
Moisture-keeping efficacy, and degradable, noresidue, it is harmless to human health and water environment.
3) present invention prepares hand cleanser using poplar flower extract for the first time, and a large amount of poplar flower resource of effective use is given up
Object utilizes, while effectively improving economic benefit.
4) present invention uses tourmaline powder, and the nutritional ingredients such as collaboration tocopherol, hyaluronic acid, olive oil have health care, antioxygen
Change, whitening, decontamination effect.
Specific embodiment
The present invention program is described further below by embodiment:
Embodiment 1:
Natural plants hand cleanser main component: 20 parts of poplar flower extract, radix macrotomiae impregnate oil 15 parts, 1.5 parts of tourmaline powder,
10 parts of plant amino acid, 3 parts of olive oil, 3 parts of tocopherol, SDS2 parts, 1 part of sodium chloride, 2 parts of hyaluronic acid, 2 parts of emollient, table
18 parts of face activating agent, 1.5 parts of suspending agent, 0.1 part of stabilizer, 0.5 part of thickener, surplus are deionized water.
A kind of preparation method of the natural plants hand cleanser of preservative free:
Poplar flower extract preparation: poplar flower is crushed, and 70% ethanol water, stirring is added by feed liquid weight ratio 1:10
Uniformly, at 100 DEG C of temperature, ultrasonic extraction 2h, ultrasonic power 250w, frequency 40kHz, 4 times of volumes are added in filtering and concentrating
95% ethyl alcohol is placed in 4 DEG C of refrigerator 36h, and the refrigerated centrifuge at revolving speed 3000rpm, 4 DEG C of temperature obtains poplar flower extract.
Radix macrotomiae impregnates oil preparation: radix macrotomiae root is crushed to 2-6cm, by 5 times of addition Sweet Almond Oils of feed liquid weight ratio, and 70
DEG C impregnate 30d, leach its effective component alkannin sufficiently, filter, obtain radix macrotomiae impregnate oil.
Poplar flower extract, radix macrotomiae immersion oil, 200 mesh fiber tourmaline powder are weighed in proportion, and olive oil, life is then added
Phenol, SDS, sodium chloride, deionized water are educated, heat and is stablized to 65 DEG C, suspending agent, surfactant, stabilizer is added in stirring, stirs
It mixes to after being completely dissolved, is cooled to 40 DEG C, stir 20min, plant amino acid, hyaluronic acid, emollient is added, is adjusted using pH
Agent adjusts pH to 6.3, stands, completely disappears to foam, liquid is transparent to obtain the final product.
Embodiment 2:
Natural plants hand cleanser main component: 30 parts of poplar flower extract, radix macrotomiae impregnate oily 10 parts, 3 parts of tourmaline powder, plant
8 parts of object amino acid, 3 parts of olive oil, 3 parts of tocopherol, SDS2 parts, 1 part of sodium chloride, 2 parts of hyaluronic acid, 2 parts of emollient, surface work
Property 25 parts of agent, 1.5 parts of suspending agent, 0.1 part of stabilizer, 0.5 part of thickener, surplus be deionized water.
A kind of preparation method of the natural plants hand cleanser of preservative free:
Poplar flower extract preparation: poplar flower is crushed, and 80% ethanol water, stirring is added by feed liquid weight ratio 1:15
Uniformly, at 90 DEG C of temperature, ultrasonic extraction 3h, ultrasonic power 250w, frequency 40kHz, 4 times of volumes are added in filtering and concentrating
95% ethyl alcohol is placed in 4 DEG C of refrigerator 36h, and the refrigerated centrifuge at revolving speed 3000rpm, 4 DEG C of temperature obtains poplar flower extract.
Radix macrotomiae impregnates oil preparation: radix macrotomiae root is crushed to 2-6cm, by 6 times of addition Sweet Almond Oils of feed liquid weight ratio, and 75
DEG C impregnate 15d, leach its effective component alkannin sufficiently, filter, obtain radix macrotomiae impregnate oil.
Poplar flower extract, radix macrotomiae immersion oil, 200 mesh fiber tourmaline powder are weighed in proportion, and olive oil, life is then added
Phenol, SDS, sodium chloride, deionized water are educated, heat and is stablized to 60 DEG C, suspending agent, surfactant, stabilizer is added in stirring, stirs
It mixes to after being completely dissolved, is cooled to 40 DEG C, stir 30min, plant amino acid, hyaluronic acid, emollient is added, is adjusted using pH
Agent adjusts pH to 6.0, stands, completely disappears to foam, liquid is transparent to obtain the final product.
Comparative example 1:
Poplar flower extract, radix macrotomiae extract are not added, remaining is identical with embodiment 1.
Comparative example 2:
Market white hand cleanser on sale.
Embodiment 3:
The natural plants hand cleanser of the preservative free prepared using embodiment 1 is test object, according to international standard GB/
T2654-2013 carries out conventional index test, the results are shown in Table 1.
The requirement of 1 embodiment of table, 1 hand cleanser indices
As shown in Table 1, the natural plants hand cleanser pH value average out to 6.3 of preservative free that prepared by embodiment 1, free from extraneous odour,
Appearance clarification, not stratified, heat-resisting cold-resistant, performance are stablized, the results show that the hand cleanser meets standard GB/T/T2654-2013.
Embodiment 4:
The natural plants hand cleanser of the preservative free prepared using embodiment 1 is test group, with embodiment 2, comparative example 1, right
The hand cleanser of ratio 2 is control group 1, control group 2, control group 3, carries out moisture retention, foaming capacity, foamed stability test, knot
Fruit is shown in Table 2.
Moisture retention measurement: the test sample of test group, control group 1, control group 2 is weighed, using glycerol as positive control, is put
In the saturation potassium acetate solution that the saturated ammonium sulfate and relative humidity that the relative humidity for entering preparation is 80% are 40%, it is placed on 25
In DEG C thermostat, different time is weighed, A0Initial hand cleanser quality is indicated, respectively after weighing Ax (6,12,24,36,48h)
Hand cleanser quality, calculation formula be moisture retention (%)=Ax/A0× 100%.
Foaming capacity measurement: it uses concussion method: 1) taking freshly prepd each group hand cleanser sample 0.5mL that plastic cylinder is added,
20mL distilled water is added, stoppers plastic cylinder with sizeable rubber stopper, sufficiently shakes 20 times, shakes direction, speed, power
Degree, temperature environment must be consistent；2) after shaking, colorimetric cylinder pipe close is removed immediately, the water of 20mL is added, and will be compared along tube wall
Foam is swept away in colour tube, record foam shake after height and the time required to adding when foam is corrupted to original mid-height after water；
3) it repeats above operation, records data.
Using foam height as the measurement of hand cleanser frothing capacity, required time when being corrupted to original mid-height with foam
Characterize the stability of foam.
Foaming capacity, foamed stability and the moisture retention measurement result of 2 each group hand cleanser of table
| Group | Foaming capacity (mm) | Foamed stability (%) | Moisture retention (%) |
| Test group | 170.3 | 98.91 | 17.3 |
| Control group 1 | 179.2 | 98.23 | 16.2 |
| Control group 2 | 168.4 | 97.81 | 11.8 |
| Control group 3 | 142.5 | 94.39 | 8.53 |
As shown in Table 2, the hand cleanser of test group and control group 1, foaming capacity, foamed stability is all fine, moisture retention
Respectively 17.3% and 16.2%, both greater than 12%；And the foaming capacity of control group 2 and control group 3, foamed stability, moisturizing
Property is all less than test group, and the moisture retention of control group 2 and control group 3 is below 12%, illustrates that poplar flower extract, radix macrotomiae mention
Object is taken to have active influence to moisture retention, foaming capacity and foamed stability.
Embodiment 5:
Hand cleanser bacteriostatic test: the natural plants hand cleanser of the preservative free prepared using embodiment 1 is test object, test
Bacterium is staphylococcus aureus, escherichia coli, Candida albicans and Bacillus paratyphosus B.
Test method: bacteriostatic test carries out under 25 DEG C of water bath conditions, and equipment used passes through autoclave sterilization, reagent
Pass through 0.22 μm of membrane filtration, the hand cleanser and control sample solution of 0.5 times of experimental concentration of 5.0ml are added in sterilizing test tubes
(PBS) 5.0ml, a formula 3 pipe.Add 0.1ml bacteria suspension in every pipe respectively, then mix, acts on to defined different time, take
0.5ml bacterium medicine mixed liquor is added to equipped in 4.5ml phosphate buffer test tube, is mixed well.Take the inoculation training of 0.5ml sample liquid
It supports, makees count plate, calculate bacteriostasis rate.Test is repeated 3 times, and test result is shown in Table 3.
The test of 3 hand cleanser fungistatic effect of table
As shown in Table 3, under the conditions of 25 DEG C of room temperature, in 2min, test specimen hand cleanser is to the antibacterial of escherichia coli
Rate is greater than 99.90%, is greater than 99.90% to the bacteriostasis rate of staphylococcus aureus, is greater than to the bacteriostasis rate of Candida albicans
97.85%, 96.37% is greater than to the bacteriostasis rate of Bacillus paratyphosus B, illustrates that hand cleanser of the present invention has excellent antibacterial effect
Fruit.
Embodiment 6:
Skin sensibiligen test: selection Wistar rat 10, half male and half female, weight 180-220g, by 5000mg/
The dosage of kg weight takes sample, smears or be pasted onto back part of animal hair removal section (range 30-40cm2), is covered with two layers of template,
It is fixed for 24 hours with the closing of nonirritant adhesive plaster.Animal subject is removed after for 24 hours, observes animal poisoning sign, observation period 7d.7d
Weighing 1 time, off-test put to death animal and observe general pathology change.The natural plant of preservative free of the present invention is smeared as the result is shown
Rat after object hand cleanser is without death, general pathology anatomical examination no abnormality seen, the equal > 5000mg/kg weight of LD50.
Routine operation in operating procedure of the invention is well known to those skilled in the art, herein without repeating.
Technical solution of the present invention is described in detail in embodiment described above, it should be understood that the above is only
For specific embodiments of the present invention, it is not intended to restrict the invention, all any modifications made in spirit of the invention,
Supplement or similar fashion substitution etc., should all be included in the protection scope of the present invention.
Claims (8)
1. a kind of natural plants hand cleanser of preservative free, which is characterized in that the raw material including following parts by weight: poplar flower is extracted
0.01-50 parts of object, radix macrotomiae impregnate 0.5-30 parts of oil；Wherein, the extracting method of the poplar flower extract includes, by poplar flower
It crushes, ethanol water is added by feed liquid weight ratio 1:5-20, stirs evenly, the ultrasonic extraction 1-3h at 80-100 DEG C of temperature,
Filtering and concentrating is added 95% ethyl alcohol of 3-5 times of volume, is placed in 4 DEG C of refrigerator 24-48h, refrigerated centrifuge obtains poplar flower extract.
2. a kind of natural plants hand cleanser of preservative free according to claim 1, which is characterized in that poplar flower extract
In extraction step, ethanol water concentration is 55-85%.
3. a kind of natural plants hand cleanser of preservative free according to claim 1, which is characterized in that poplar flower extract
In extraction step, ultrasonic power 250w, frequency 40kHz.
4. a kind of natural plants hand cleanser of preservative free according to claim 1, which is characterized in that poplar flower extract
In extraction step, the revolving speed of refrigerated centrifuge is 3000rpm, and centrifuging temperature is 4 DEG C.
5. a kind of natural plants hand cleanser of preservative free according to claim 1, which is characterized in that the radix macrotomiae leaching
Bubble oil preparation includes that radix macrotomiae root is crushed to 2-6cm, and Sweet Almond Oil, 60-80 DEG C of immersion is added by 4-6 times of feed liquid weight ratio
10-30d leaches its effective component alkannin sufficiently, filtering, obtains radix macrotomiae and impregnates oil.
6. a kind of natural plants hand cleanser of preservative free according to claim 1, which is characterized in that hand cleanser raw material is also
Including 0.5-5 parts of tourmaline powder, 0.5-15 parts of plant amino acid；Wherein, tourmaline powder is preferably fiber tourmaline powder, fineness 200
Mesh.
7. a kind of preparation method of the natural plants hand cleanser of preservative free, which is characterized in that weigh poplar flower extraction in proportion
Object, radix macrotomiae impregnate oil, tourmaline powder, and olive oil, tocopherol, SDS, sodium chloride, deionized water is then added, and heat and stablize extremely
60-70 DEG C, suspending agent, surfactant, stabilizer, thickener is added in stirring, stirs to after being completely dissolved, is cooled to 40 DEG C,
15-30min is stirred, plant amino acid, hyaluronic acid, emollient is added, adjusts pH to 5.5-6.8 using pH adjusting agent, stand,
It is completely disappeared to foam, liquid is transparent to obtain the final product.
8. natural plants hand cleanser pH stable made from -7 any one according to claim 1, weakly acidic；Moisture retention is not less than
12%；98% is greater than to escherichia coli and staphylococcus aureus bacteriostasis rate, to Candida albicans and Bacillus paratyphosus B
Bacteriostasis rate be greater than 95%.
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Application publication date: 20190129 |