CN109260453A - 一种具有杀菌消炎功能的中药组合物及其制备方法 - Google Patents
一种具有杀菌消炎功能的中药组合物及其制备方法 Download PDFInfo
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- CN109260453A CN109260453A CN201811536537.4A CN201811536537A CN109260453A CN 109260453 A CN109260453 A CN 109260453A CN 201811536537 A CN201811536537 A CN 201811536537A CN 109260453 A CN109260453 A CN 109260453A
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Abstract
一种具有杀菌消炎功能的中药组合物,由以下重量份的原料制备而成:杨树芽60‑80份,白芷8‑10份,决明子3‑6份、姜3‑6份、薄荷3‑6份、葛根3‑6份。本发明提供的中药组合物,富有独特的生物活性,是天然的、绿色的、无污染的能提高人体免疫力物质;具有广泛的抗菌、抗病毒功能,对致病菌、病毒等有抑制或杀灭作用;具有消炎镇痛的作用,对皮肤炎症、口腔炎症、脏腑炎症,具有很好的消除及愈合康复作用;具有促进细胞再生的作用,创伤、烧伤、烫伤,对其伤口愈合有很好的作用。
Description
技术领域
本发明属于中药生产技术领域,具体涉及一种具有杀菌消炎功能的中药组合物及其制备方法。
背景技术
2016年5月27号晚间新闻报导美国出现“超级细菌”,使最强抗生素“粘菌素”也丧失效力。由于抗菌素的乱用,使细菌耐药性增强。美国每年有200多万人受到耐药菌感染,有23000人死于耐药菌感染。
抗生素主要是由细菌、霉菌或其他微生物产生的次级代谢产物或人工合成的类似物。现临床常用的抗生素有转基因工程菌、培养液液中提取物以及用化学方法合成或半合成的化合物。
抗生素主要用于治疗各种细菌感染或致病微生物感染类疾病。在中国,患者抗生素的使用率达到70%,是欧美国家的两倍,但真正需要使用的不到20%。预防性使用抗生素是典型的滥用抗生素。随着抗生素的广泛应用,细菌的耐药问题越来越严重。
人们通过开发新的抗生素来解决耐药问题,但现在开发新抗生素的速度已经远远赶不上细菌耐药的脚步。因此,通过控制抗生素使用来减慢耐药细菌的蔓延、开发利用无副作用的天然抗生素来抵御病菌感染是最佳途径。
我国有一些中草药就是天然的“植物抗生素”。 中药中有多种具有清热解毒的草药如蒲公英、金银花、黄连、黄芩、黄柏、大黄、紫花地丁、野菊花、连翘、百部、鱼腥草、大蒜、艾叶、白芷、姜、芦荟等有广谱抗菌作用。由于中药与临床上使用的抗生素抗菌作用机制不同,中药中多种组分发挥协同抗菌作用,细菌不易产生明显的耐药性。因此,发挥传统中药的抗菌作用无疑为细菌耐药的治疗提供了一种全新而且可行之路。
发明内容
本发明的目的就在于为解决现有技术的不足而提供一种具有杀菌消炎功能的中药组合物及其制备方法。
本发明的目的是以下述技术方案实现的:
一种具有杀菌消炎功能的中药组合物,由以下重量份的原料制备而成:杨树芽60-80份,白芷8-10份,决明子3-6份、姜3-6份、薄荷3-6份、葛根3-6份。
优选的,由以下重量份的原料制备而成:杨树芽70份,白芷9份,决明子5份、姜5份、薄荷5份、葛根5份。
优选的,由以下重量份的原料制备而成:杨树芽78份,白芷9份,决明子3份、姜3份、薄荷3份、葛根3份。
所述姜为干姜。
所述中药组合物剂型为精油或喷雾剂。
如上所述的具有杀菌消炎功能的中药组合物的制备方法,包括以下步骤:
(1)取上述原料混合,加入乙醇中浸泡2-7d;或加入丙二醇中浸泡5-10d,乙醇、丙二醇的用量为原料药的3-4倍(mL/g);
(2)过滤,即得。
优选的,包括以下步骤:
(1)分拣,将采集的杨树芽、白芷、决明子、姜、薄荷、葛根中的杂质分拣出来;
(2)冲洗,将分拣干净的杨树芽、白芷、决明子、姜、薄荷、葛根在水中浸泡5-15min,然后进行冲洗;
(3)晾晒,将冲洗过的杨树芽、白芷、决明子、姜、薄荷、葛根移至阴凉处晾晒至干,含水量不超过5%;
(4)粉碎,将晾晒好的杨树芽、白芷、决明子、姜、薄荷、葛根粉碎;
(5)浸泡,将粉碎后的杨树芽、白芷、决明子、姜、薄荷、葛根放入乙醇中浸泡2-7天,或者放入丙二醇中浸泡5-10d;
(6)分离,将浸泡好的杨树芽、白芷、决明子、姜、薄荷、葛根过滤,弃去滤渣,即得。
本发明提供的中药组合物,一可提高人体免疫力;二可有效杀菌消毒;其有益效果具体包括以下方面:
(1)富有独特的生物活性,是天然的、绿色的、无污染的能提高人体免疫力物质;
(2)具有广泛的抗菌、抗病毒功能,对致病菌、病毒等有抑制或杀灭作用;
(3)具有消炎镇痛的作用,对皮肤炎症、口腔炎症、脏腑炎症,具有很好的消除及愈合康复作用;
(4)具有促进细胞再生的作用,创伤、烧伤、烫伤,对其伤口愈合有很好的作用。
具体实施方式
实施例1
一种具有杀菌消炎功能的中药组合物,由以下重量份的原料制备而成:杨树芽60-80份,白芷8-10份,决明子3-6份、姜3-6份、薄荷3-6份、葛根3-6份。姜采用干姜。可内服可外用。
如上所述的具有杀菌消炎功能的中药组合物的制备方法,包括以下步骤:
(1)取上述原料混合,加入乙醇中浸泡2-7d;或加入丙二醇中浸泡5-10d;乙醇、丙二醇的用量为原料药的3-4倍(mL/g);
(2)过滤得到精油,或置于喷剂瓶中,制作为喷雾剂。
具体的,包括以下步骤:
(1)分拣,将采集的杨树芽、白芷、决明子、姜、薄荷、葛根中的杂质分拣出来;
(2)冲洗,将分拣干净的杨树芽、白芷、决明子、姜、薄荷、葛根在水中浸泡5-15min,然后进行冲洗;
(3)晾晒,将冲洗过的杨树芽、白芷、决明子、姜、薄荷、葛根移至阴凉处晾晒至干,含水量不超过5%;
(4)粉碎,将晾晒好的杨树芽、白芷、决明子、姜、薄荷、葛根在粉碎机内粉碎成渣状;
(5)浸泡,将粉碎后的杨树芽、白芷、决明子、姜、薄荷、葛根放入乙醇中浸泡2-7天,或者放入丙二醇中浸泡5-10d;
(6)分离,将浸泡好的杨树芽、白芷、决明子、姜、薄荷、葛根过滤,弃去滤渣,即得。
组方中,杨树在我国长江以北到处都有,杨树芽是在每年的12月份至2月份树木发芽前取得,来源广泛丰富,主要来自成材林的砍伐,成长林的间伐和小树的修枝;杨树芽,气味芳香、微苦且辛辣,具有抗菌消炎和排毒防腐的功效;
白芷可解表散寒,祛风止痛,通鼻窍,燥湿止带,消肿排脓,祛风止痒;用于头痛、牙痛、鼻渊、肠风痔漏、赤白带下、痈疽疮疡、皮肤瘙痒;
决明子是“决明”的种子,为常用中药,种子入药,具有清肝明目、利水通便的功能;主治高血压、头痛、眩晕、急性结膜炎、角膜溃疡、青光眼、痈疖疮疡等症;外治肿毒、癣疾;
干姜味辛,性热;归脾、胃、心、肺经;可温中散寒,回阳通脉,燥湿消痰,温肺化饮、抑菌、抗炎作用;主治脘腹冷痛;呕吐;泄泻,亡阳厥逆;寒饮喘咳;寒湿痹痛;
薄荷是辛凉性发汗解热药,还具有防腐杀菌、利尿、化痰、健胃和助消化等功效;主治流行性感冒、头疼、目赤、身热、咽喉、牙床肿痛等症;外用可治神经痛、皮肤瘙痒、皮疹和湿疹等;
葛根甘、辛,凉;有解肌退热,透疹,生津止渴,升阳止泻之功;常用于表证发热,项背强痛,麻疹不透,热病口渴,阴虚消渴,热泻热痢,脾虚泄泻;
将杨树芽、白芷、决明子、干姜、薄荷、葛根组合,杨树芽、干姜主杀菌抗病毒,白芷、决明子主通窍止痛,薄荷、葛根主清热解毒,外用时在乙醇或丙二醇溶剂作用下可快速渗透皮肤,发挥药效,具有显著的消炎、止血、生肌、愈合的作用;而且药性温和,安全无毒;可用于:
1 、皮肤碰伤、小面积溃疡;在伤处滴上2-3滴外用精油,一天3-4次;
2、 蚊虫叮咬、局部红肿、小毒疖、关节及局部疼痛,于患处轻揉后滴上一之数滴外用精油;
3 、鼻炎;使用时将鼻子搓热,将外用精油滴于上面涂抹均匀;轻微中耳炎;使用时将油滴入耳内,一天2-3次;
4 灰指甲、甲沟炎;将外用精油涂抹于患处,一天早晚两次;
5 、带状疱疹、褥疮;将外用精油涂抹于患处,一天数次;
6、 感冒初期,将外用精油涂于上嘴唇、鼻孔、鼻部,一天数次,可减轻症状;
7 、还可内服所制备的内服药剂,相当于抗生素,可消体内炎症;提高免疫力。
实施例2
一种具有杀菌功能的中药组合物,由以下重量份的原料制备而成:杨树芽70g,白芷9g,决明子5g、干姜5g、薄荷5g、葛根5g。
其制备方法包括以下步骤:
(1)分拣,将采集的杨树芽、白芷、决明子、姜、薄荷、葛根中的杂质分拣出来;
(2)冲洗,将分拣干净的杨树芽、白芷、决明子、姜、薄荷、葛根在水中浸泡10min,然后进行冲洗;
(3)晾晒,将冲洗过的杨树芽、白芷、决明子、姜、薄荷、葛根移至阴凉处晾晒至干,含水量不超过5%;
(4)粉碎,将晾晒好的杨树芽、白芷、决明子、姜、薄荷、葛根在粉碎机内粉碎成渣状;
(5)浸泡,将粉碎后的杨树芽、白芷、决明子、姜、薄荷、葛根放入350mL乙醇中浸泡3天;
(6)分离,将浸泡好的杨树芽、白芷、决明子、姜、薄荷、葛根过滤,弃去滤渣,即得。
实施例3
一种具有杀菌功能的中药组合物,由以下重量份的原料制备而成:杨树芽78g,白芷9g,决明子3g、干姜3g、薄荷3g、葛根3g。
其制备方法包括以下步骤:
(1)分拣,将采集的杨树芽、白芷、决明子、姜、薄荷、葛根中的杂质分拣出来;
(2)冲洗,将分拣干净的杨树芽、白芷、决明子、姜、薄荷、葛根在水中浸泡10min,然后进行冲洗;
(3)晾晒,将冲洗过的杨树芽、白芷、决明子、姜、薄荷、葛根移至阴凉处晾晒至干,含水量不超过5%;
(4)粉碎,将晾晒好的杨树芽、白芷、决明子、姜、薄荷、葛根在粉碎机内粉碎成渣状;
(5)浸泡,将粉碎后的杨树芽、白芷、决明子、姜、薄荷、葛根放入350mL丙二醇中浸泡7天;
(6)分离,将浸泡好的杨树芽、白芷、决明子、姜、薄荷、葛根过滤,弃去滤渣,即得。
实施例4
一种具有杀菌功能的中药组合物,由以下重量份的原料制备而成:杨树芽65g,白芷9g,决明子5g、干姜3g、薄荷5g、葛根5g。
其制备方法包括以下步骤:
(1)分拣,将采集的杨树芽、白芷、决明子、姜、薄荷、葛根中的杂质分拣出来;
(2)冲洗,将分拣干净的杨树芽、白芷、决明子、姜、薄荷、葛根在水中浸泡10min,然后进行冲洗;
(3)晾晒,将冲洗过的杨树芽、白芷、决明子、姜、薄荷、葛根移至阴凉处晾晒至干,含水量不超过5%;
(4)粉碎,将晾晒好的杨树芽、白芷、决明子、姜、薄荷、葛根在粉碎机内粉碎成渣状;
(5)浸泡,将粉碎后的杨树芽、白芷、决明子、姜、薄荷、葛根放入360mL丙二醇中浸泡9天;
(6)分离,将浸泡好的杨树芽、白芷、决明子、姜、薄荷、葛根过滤,弃去滤渣,滤液置于喷剂瓶中制成喷雾剂。
实施例5
一种具有杀菌功能的中药组合物,由以下重量份的原料制备而成:杨树芽75g,白芷8g,决明子6g、干姜5g、薄荷4g、葛根3g。
其制备方法包括以下步骤:
(1)分拣,将采集的杨树芽、白芷、决明子、姜、薄荷、葛根中的杂质分拣出来;
(2)冲洗,将分拣干净的杨树芽、白芷、决明子、姜、薄荷、葛根在水中浸泡10min,然后进行冲洗;
(3)晾晒,将冲洗过的杨树芽、白芷、决明子、姜、薄荷、葛根移至阴凉处晾晒至干,含水量不超过5%;
(4)粉碎,将晾晒好的杨树芽、白芷、决明子、姜、薄荷、葛根在粉碎机内粉碎成渣状;
(5)浸泡,将粉碎后的杨树芽、白芷、决明子、姜、薄荷、葛根放入270mL乙醇中浸泡5天;
(6)分离,将浸泡好的杨树芽、白芷、决明子、姜、薄荷、葛根过滤,弃去滤渣,滤液置于喷剂瓶中制成喷雾剂。
实施例6
一种具有杀菌功能的中药组合物,由以下重量份的原料制备而成:杨树芽80g,白芷9g,决明子4g、干姜5g、薄荷3g、葛根4g。
其制备方法包括以下步骤:
(1)分拣,将采集的杨树芽、白芷、决明子、姜、薄荷、葛根中的杂质分拣出来;
(2)冲洗,将分拣干净的杨树芽、白芷、决明子、姜、薄荷、葛根在水中浸泡10min,然后进行冲洗;
(3)晾晒,将冲洗过的杨树芽、白芷、决明子、姜、薄荷、葛根移至阴凉处晾晒至干,含水量不超过5%;
(4)粉碎,将晾晒好的杨树芽、白芷、决明子、姜、薄荷、葛根在粉碎机内粉碎成渣状;
(5)浸泡,将粉碎后的杨树芽、白芷、决明子、姜、薄荷、葛根放入340mL乙醇中浸泡7天;
(6)分离,将浸泡好的杨树芽、白芷、决明子、姜、薄荷、葛根过滤,弃去滤渣,即得。
实施例7
一种具有杀菌功能的中药组合物,由以下重量份的原料制备而成:杨树芽70g,白芷9g,决明子3g、干姜6g、薄荷5g、葛根6g。
其制备方法包括以下步骤:
(1)分拣,将采集的杨树芽、白芷、决明子、姜、薄荷、葛根中的杂质分拣出来;
(2)冲洗,将分拣干净的杨树芽、白芷、决明子、姜、薄荷、葛根在水中浸泡10min,然后进行冲洗;
(3)晾晒,将冲洗过的杨树芽、白芷、决明子、姜、薄荷、葛根移至阴凉处晾晒至干,含水量不超过5%;
(4)粉碎,将晾晒好的杨树芽、白芷、决明子、姜、薄荷、葛根在粉碎机内粉碎成渣状;
(5)浸泡,将粉碎后的杨树芽、白芷、决明子、姜、薄荷、葛根放入350mL乙醇中浸泡6天;
(6)分离,将浸泡好的杨树芽、白芷、决明子、姜、薄荷、葛根过滤,弃去滤渣,即得。
实施例8
一种具有杀菌功能的中药组合物,由以下重量份的原料制备而成:杨树芽60g,白芷10g,决明子5g、干姜5g、薄荷4g、葛根6g。
其制备方法包括以下步骤:
(1)分拣,将采集的杨树芽、白芷、决明子、姜、薄荷、葛根中的杂质分拣出来;
(2)冲洗,将分拣干净的杨树芽、白芷、决明子、姜、薄荷、葛根在水中浸泡10min,然后进行冲洗;
(3)晾晒,将冲洗过的杨树芽、白芷、决明子、姜、薄荷、葛根移至阴凉处晾晒至干,含水量不超过5%;
(4)粉碎,将晾晒好的杨树芽、白芷、决明子、姜、薄荷、葛根在粉碎机内粉碎成渣状;
(5)浸泡,将粉碎后的杨树芽、白芷、决明子、姜、薄荷、葛根放入300mL丙二醇中浸泡5天;
(6)分离,将浸泡好的杨树芽、白芷、决明子、姜、薄荷、葛根过滤,弃去滤渣,即得。
药效试验
1、对疖子的治疗效果试验
疖子常见症状是局部红、肿、痛小结节,逐渐肿大,锥形隆起,最常见的是由金黄色葡萄球菌感染引起的。选取患者26例,涂抹实施例2制备得到的精油,每天3次,期间忌生、冷、辛辣,停止其他中西药及保健品。
疗效评判标准:治愈:肿痛消失,皮肤愈合;显效:肿痛减弱;无效:主要症状没有减轻,红肿疼痛加重,形成脓肿。
用药1天后,23例显效,肿痛得到控制,用药3天治愈;另外3人用药5天治愈,有效率为100%,而且疗程短,将近90%的患者用药一天病情即得到控制,用药3天即得到治愈。
2对皮肤破伤感染的治疗效果试验
皮肤受到外伤或手术以后,病原微生物容易通过伤口侵入机体,在体内生长、繁殖,致机体的正常功能、代谢、组织结构受到破坏,引起组织损伤性病变。常见症状化脓、肿痛、创口不愈合、发热等。选取因外伤感染患者24例,涂抹实施例2制备得到的精油,每天3-4次,期间忌生、冷、辛辣,停止其他中西药及保健品。
疗效评判标准:治愈:创口发炎症状消失,皮肤愈合;显效:创口发炎有所缓解,疼痛稍有减轻;无效:主要症状没有减轻,创口痛疼不减,伤口经久不见好转。
用药1天后,20例显效,用药3天治愈;另外4人用药5天治愈,总有效率为100%。
3对甲沟炎的治疗效果试验
指甲除游离缘外,其余三边均与皮肤皱褶相接,连接部形成沟状,称为甲沟。甲沟炎即在甲沟部位发生的感染。常见症状为甲沟红肿、疼痛、化脓感染时可见黄白色脓液。选取甲沟炎患者19例,涂抹实施例3制备得到的精油,每天早晚2次,期间忌生、冷、辛辣,停止其他中西药及保健品。
疗效评判标准:治愈:症状消失;显效:症状减轻;无效:主要症状没有减轻,甚至加重。
其中用药3天后,16例治愈;用药5天后,另3例也治愈,总有效率为100%。
典型病例
1 李某,男,38岁,喉咙肿疼,用实施例2制备得到的精油涂抹2天,每天3次,好转,第四天全好。
2刘某,女,跌倒手被钢丝划破,伤口长且深,并出现化脓,涂抹实施例2制备得到的精油滴涂,每天3次,两天后愈合。
3马某,手术后伤口感染,使用实施例2制备得到的精油,每天3次,第二天炎症消去。
4赵某,女,患甲沟炎,使用实施例2制备得到的精油,每天2次,当天消肿,三天即好。
5周某,中耳炎感染,滴用实施例3制备得到的精油,每天3-5次,三天即好。
6杨某,脖子出红斑瘙痒,涂抹实施例2制备得到的精油,每天3次,两天就好。
7金某,感冒咳嗽,服用实施例2制备得到的精油,每次1mL,每天3次(原料中乙醇采用药用级),五天后全好,且多月的小腹不舒现象也没有了;
8 黄某,长期胃炎,服用实施例3制备得到的精油,每次1mL,每天3次(原料中丙二醇采用药用级),一周大为好转,半月后痊愈;
9 赵某,先是幽门螺旋杆菌感染,后胃溃疡多地治疗未效,后服用实施例2制备得到的精油,每次1mL,每天3次(原料中乙醇采用药用级)半月感觉症状消失,坚持服一个月后痊愈。
Claims (6)
1.一种具有杀菌消炎功能的中药组合物,其特征在于由以下重量份的原料制备而成:杨树芽60-80份,白芷8-10份,决明子3-6份、姜3-6份、薄荷3-6份、葛根3-6份。
2.如权利要求1所述的具有杀菌消炎功能的中药组合物,其特征在于由以下重量份的原料制备而成:杨树芽70份,白芷9份,决明子5份、姜5份、薄荷5份、葛根5份。
3.如权利要求1所述的具有杀菌消炎功能的中药组合物,其特征在于由以下重量份的原料制备而成:杨树芽78份,白芷9份,决明子3份、姜3份、薄荷3份、葛根3份。
4.如权利要求1-3任一项所述的具有杀菌消炎功能的中药组合物,其特征在于所述姜为干姜。
5.如权利要求1-4任一项所述的具有杀菌消炎功能的中药组合物的制备方法,其特征在于包括以下步骤:
(1)取上述原料混合,加入乙醇中浸泡2-7d;或加入丙二醇中浸泡5-10d,乙醇、丙二醇的用量为原料药的3-4倍(mL/g);
(2)过滤,即得。
6.如权利要求5所述的具有杀菌消炎功能的中药组合物的制备方法,其特征在于包括以下步骤:
(1)分拣,将采集的杨树芽、白芷、决明子、姜、薄荷、葛根中的杂质分拣出来;
(2)冲洗,将分拣干净的杨树芽、白芷、决明子、姜、薄荷、葛根在水中浸泡5-15min,然后进行冲洗;
(3)晾晒,将冲洗过的杨树芽、白芷、决明子、姜、薄荷、葛根移至阴凉处晾晒至干,含水量不超过5%;
(4)粉碎,将晾晒好的杨树芽、白芷、决明子、姜、薄荷、葛根粉碎;
(5)浸泡,将粉碎后的杨树芽、白芷、决明子、姜、薄荷、葛根放入乙醇中浸泡2-7天,或者放入丙二醇中浸泡5-10d;
(6)分离,将浸泡好的杨树芽、白芷、决明子、姜、薄荷、葛根过滤,弃去滤渣,即得。
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