CN104491491A - 一种预防破伤风的中药喷雾剂及其制备方法 - Google Patents
一种预防破伤风的中药喷雾剂及其制备方法 Download PDFInfo
- Publication number
- CN104491491A CN104491491A CN201410762968.8A CN201410762968A CN104491491A CN 104491491 A CN104491491 A CN 104491491A CN 201410762968 A CN201410762968 A CN 201410762968A CN 104491491 A CN104491491 A CN 104491491A
- Authority
- CN
- China
- Prior art keywords
- parts
- ophidia
- medicinal herb
- radix
- filtrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000007921 spray Substances 0.000 title claims abstract description 59
- 239000003814 drug Substances 0.000 title claims abstract description 53
- 238000002360 preparation method Methods 0.000 title claims description 25
- 206010043376 Tetanus Diseases 0.000 title abstract description 19
- 241000270295 Serpentes Species 0.000 claims abstract description 46
- 241000628997 Flos Species 0.000 claims description 51
- 239000000706 filtrate Substances 0.000 claims description 49
- 229940079593 drug Drugs 0.000 claims description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 24
- 239000009286 sanguis draxonis Substances 0.000 claims description 21
- 238000007654 immersion Methods 0.000 claims description 14
- 230000002265 prevention Effects 0.000 claims description 11
- 238000007789 sealing Methods 0.000 claims description 11
- 238000009835 boiling Methods 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 7
- 239000006228 supernatant Substances 0.000 claims description 7
- 230000000694 effects Effects 0.000 abstract description 11
- 208000002193 Pain Diseases 0.000 abstract description 10
- 239000008280 blood Substances 0.000 abstract description 10
- 210000004369 blood Anatomy 0.000 abstract description 10
- 210000003205 muscle Anatomy 0.000 abstract description 10
- 230000036407 pain Effects 0.000 abstract description 10
- 210000002435 tendon Anatomy 0.000 abstract description 5
- 239000002994 raw material Substances 0.000 abstract description 4
- 230000002040 relaxant effect Effects 0.000 abstract description 4
- 239000009136 dragon's blood Substances 0.000 abstract description 3
- 235000014290 Artemisia anomala Nutrition 0.000 abstract description 2
- 241000123844 Artemisia anomala Species 0.000 abstract description 2
- 244000035851 Chrysanthemum leucanthemum Species 0.000 abstract description 2
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 abstract description 2
- 240000004824 Trimezia steyermarkii Species 0.000 abstract description 2
- 235000008216 herbs Nutrition 0.000 abstract description 2
- 241000205585 Aquilegia canadensis Species 0.000 abstract 1
- 241000305491 Gastrodia elata Species 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 240000004370 Pastinaca sativa Species 0.000 abstract 1
- 235000017769 Pastinaca sativa subsp sativa Nutrition 0.000 abstract 1
- 241000316658 Sauromatum giganteum Species 0.000 abstract 1
- 230000003467 diminishing effect Effects 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000001954 sterilising effect Effects 0.000 abstract 1
- 206010052428 Wound Diseases 0.000 description 12
- 208000027418 Wounds and injury Diseases 0.000 description 12
- 208000024891 symptom Diseases 0.000 description 11
- 208000005392 Spasm Diseases 0.000 description 8
- 201000010099 disease Diseases 0.000 description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
- 210000003414 extremity Anatomy 0.000 description 8
- 235000009508 confectionery Nutrition 0.000 description 7
- 210000004185 liver Anatomy 0.000 description 7
- 230000017531 blood circulation Effects 0.000 description 6
- 206010025482 malaise Diseases 0.000 description 6
- 208000006820 Arthralgia Diseases 0.000 description 5
- 206010019233 Headaches Diseases 0.000 description 5
- 231100000869 headache Toxicity 0.000 description 5
- 231100000614 poison Toxicity 0.000 description 5
- 230000001737 promoting effect Effects 0.000 description 5
- 230000008961 swelling Effects 0.000 description 5
- 206010007247 Carbuncle Diseases 0.000 description 4
- 206010010904 Convulsion Diseases 0.000 description 4
- 241000721047 Danaus plexippus Species 0.000 description 4
- 230000000202 analgesic effect Effects 0.000 description 4
- 239000002260 anti-inflammatory agent Substances 0.000 description 4
- 230000001741 anti-phlogistic effect Effects 0.000 description 4
- 230000002096 anti-tetanic effect Effects 0.000 description 4
- 238000011534 incubation Methods 0.000 description 4
- 201000007227 lymph node tuberculosis Diseases 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 239000006188 syrup Substances 0.000 description 4
- 235000020357 syrup Nutrition 0.000 description 4
- 241000208838 Asteraceae Species 0.000 description 3
- 241000193449 Clostridium tetani Species 0.000 description 3
- 206010019468 Hemiplegia Diseases 0.000 description 3
- 208000025747 Rheumatic disease Diseases 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 230000036461 convulsion Effects 0.000 description 3
- 208000002173 dizziness Diseases 0.000 description 3
- 239000003205 fragrance Substances 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 239000012567 medical material Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 230000000552 rheumatic effect Effects 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- 239000003440 toxic substance Substances 0.000 description 3
- UWQZVUQKBWZNLN-UHFFFAOYSA-N 4-(Ethoxymethyl)phenol Chemical compound CCOCC1=CC=C(O)C=C1 UWQZVUQKBWZNLN-UHFFFAOYSA-N 0.000 description 2
- BGEBZHIAGXMEMV-UHFFFAOYSA-N 5-methoxypsoralen Chemical compound O1C(=O)C=CC2=C1C=C1OC=CC1=C2OC BGEBZHIAGXMEMV-UHFFFAOYSA-N 0.000 description 2
- 208000000187 Abnormal Reflex Diseases 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 2
- 201000000736 Amenorrhea Diseases 0.000 description 2
- 206010001928 Amenorrhoea Diseases 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 241000345998 Calamus manan Species 0.000 description 2
- 206010008190 Cerebrovascular accident Diseases 0.000 description 2
- 206010017553 Furuncle Diseases 0.000 description 2
- PUQSUZTXKPLAPR-UJPOAAIJSA-N Gastrodin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(CO)C=C1 PUQSUZTXKPLAPR-UJPOAAIJSA-N 0.000 description 2
- 206010062717 Increased upper airway secretion Diseases 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- FLIACVVOZYBSBS-UHFFFAOYSA-N Methyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC FLIACVVOZYBSBS-UHFFFAOYSA-N 0.000 description 2
- 208000007101 Muscle Cramp Diseases 0.000 description 2
- 206010062575 Muscle contracture Diseases 0.000 description 2
- 208000006011 Stroke Diseases 0.000 description 2
- 208000025865 Ulcer Diseases 0.000 description 2
- 230000003187 abdominal effect Effects 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 231100000540 amenorrhea Toxicity 0.000 description 2
- 230000036592 analgesia Effects 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 238000009395 breeding Methods 0.000 description 2
- 230000001488 breeding effect Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 208000006111 contracture Diseases 0.000 description 2
- DOIRQSBPFJWKBE-UHFFFAOYSA-N dibutyl phthalate Chemical compound CCCCOC(=O)C1=CC=CC=C1C(=O)OCCCC DOIRQSBPFJWKBE-UHFFFAOYSA-N 0.000 description 2
- 230000001815 facial effect Effects 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 210000002216 heart Anatomy 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 208000006750 hematuria Diseases 0.000 description 2
- 241000411851 herbal medicine Species 0.000 description 2
- 210000001624 hip Anatomy 0.000 description 2
- 230000035859 hyperreflexia Effects 0.000 description 2
- 206010020745 hyperreflexia Diseases 0.000 description 2
- 210000003026 hypopharynx Anatomy 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000005906 menstruation Effects 0.000 description 2
- 230000001314 paroxysmal effect Effects 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 208000026435 phlegm Diseases 0.000 description 2
- 238000004393 prognosis Methods 0.000 description 2
- 235000012950 rattan cane Nutrition 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 230000008736 traumatic injury Effects 0.000 description 2
- 231100000397 ulcer Toxicity 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- URINFYYBTXOQCT-OUUBHVDSSA-N (2r,3s,4s,5r,6s)-2-(hydroxymethyl)-6-[4-[(4-hydroxyphenyl)methoxymethyl]phenoxy]oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC(C=C1)=CC=C1COCC1=CC=C(O)C=C1 URINFYYBTXOQCT-OUUBHVDSSA-N 0.000 description 1
- HRGUSFBJBOKSML-UHFFFAOYSA-N 3',5'-di-O-methyltricetin Chemical compound COC1=C(O)C(OC)=CC(C=2OC3=CC(O)=CC(O)=C3C(=O)C=2)=C1 HRGUSFBJBOKSML-UHFFFAOYSA-N 0.000 description 1
- RGHHSNMVTDWUBI-UHFFFAOYSA-N 4-hydroxybenzaldehyde Chemical compound OC1=CC=C(C=O)C=C1 RGHHSNMVTDWUBI-UHFFFAOYSA-N 0.000 description 1
- ZHESTCBHMHKZNL-UHFFFAOYSA-N 5,7-dihydroxy-6-methoxy-2-(3,4,5-trimethoxyphenyl)chromen-4-one Chemical compound COC1=C(OC)C(OC)=CC(C=2OC3=CC(O)=C(OC)C(O)=C3C(=O)C=2)=C1 ZHESTCBHMHKZNL-UHFFFAOYSA-N 0.000 description 1
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 206010063409 Acarodermatitis Diseases 0.000 description 1
- 241000759271 Alangium Species 0.000 description 1
- 241001254604 Angelica pubescens Species 0.000 description 1
- 206010003011 Appendicitis Diseases 0.000 description 1
- 206010003497 Asphyxia Diseases 0.000 description 1
- 208000008035 Back Pain Diseases 0.000 description 1
- DBMJZOMNXBSRED-UHFFFAOYSA-N Bergamottin Natural products O1C(=O)C=CC2=C1C=C1OC=CC1=C2OCC=C(C)CCC=C(C)C DBMJZOMNXBSRED-UHFFFAOYSA-N 0.000 description 1
- 241000255791 Bombyx Species 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 240000005250 Chrysanthemum indicum Species 0.000 description 1
- 235000018959 Chrysanthemum indicum Nutrition 0.000 description 1
- 241000903946 Clematidis Species 0.000 description 1
- 244000205754 Colocasia esculenta Species 0.000 description 1
- 235000006481 Colocasia esculenta Nutrition 0.000 description 1
- 241000270292 Colubridae Species 0.000 description 1
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 1
- 206010010741 Conjunctivitis Diseases 0.000 description 1
- 241000125183 Crithmum maritimum Species 0.000 description 1
- 206010011703 Cyanosis Diseases 0.000 description 1
- 244000019459 Cynara cardunculus Species 0.000 description 1
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 1
- 241001561260 Dracaena cambodiana Species 0.000 description 1
- 241000292342 Dracaena cochinchinensis Species 0.000 description 1
- 208000005171 Dysmenorrhea Diseases 0.000 description 1
- 206010013935 Dysmenorrhoea Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 201000000297 Erysipelas Diseases 0.000 description 1
- 208000015220 Febrile disease Diseases 0.000 description 1
- 241000555712 Forsythia Species 0.000 description 1
- 206010017577 Gait disturbance Diseases 0.000 description 1
- 241000305492 Gastrodia Species 0.000 description 1
- 208000034507 Haematemesis Diseases 0.000 description 1
- 208000004547 Hallucinations Diseases 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 206010021118 Hypotonia Diseases 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 206010061245 Internal injury Diseases 0.000 description 1
- 206010024229 Leprosy Diseases 0.000 description 1
- 241000234280 Liliaceae Species 0.000 description 1
- 244000167230 Lonicera japonica Species 0.000 description 1
- 235000017617 Lonicera japonica Nutrition 0.000 description 1
- 241001570521 Lonicera periclymenum Species 0.000 description 1
- 208000008930 Low Back Pain Diseases 0.000 description 1
- 206010025421 Macule Diseases 0.000 description 1
- 241000283956 Manis Species 0.000 description 1
- 208000019255 Menstrual disease Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- QXKHYNVANLEOEG-UHFFFAOYSA-N Methoxsalen Chemical compound C1=CC(=O)OC2=C1C=C1C=COC1=C2OC QXKHYNVANLEOEG-UHFFFAOYSA-N 0.000 description 1
- 206010027514 Metrorrhagia Diseases 0.000 description 1
- 206010028331 Muscle rupture Diseases 0.000 description 1
- 206010061533 Myotonia Diseases 0.000 description 1
- 244000021150 Orbignya martiana Species 0.000 description 1
- 235000014643 Orbignya martiana Nutrition 0.000 description 1
- 241000244269 Peucedanum Species 0.000 description 1
- 241000237636 Pheretima Species 0.000 description 1
- IDDMFNIRSJVBHE-UHFFFAOYSA-N Piscigenin Natural products COC1=C(O)C(OC)=CC(C=2C(C3=C(O)C=C(O)C=C3OC=2)=O)=C1 IDDMFNIRSJVBHE-UHFFFAOYSA-N 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 241000270273 Ptyas dhumnades Species 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 206010037714 Quadriplegia Diseases 0.000 description 1
- 206010038669 Respiratory arrest Diseases 0.000 description 1
- 241000447727 Scabies Species 0.000 description 1
- 241000131808 Scolopendra Species 0.000 description 1
- 241000522620 Scorpio Species 0.000 description 1
- 206010039897 Sedation Diseases 0.000 description 1
- 241000780602 Senecio Species 0.000 description 1
- 241000238370 Sepia Species 0.000 description 1
- 208000032140 Sleepiness Diseases 0.000 description 1
- 206010041349 Somnolence Diseases 0.000 description 1
- 241000800405 Spatholobus suberectus Species 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 206010053615 Thermal burn Diseases 0.000 description 1
- 241000746716 Typhonium Species 0.000 description 1
- PCWZKQSKUXXDDJ-UHFFFAOYSA-N Xanthotoxin Natural products COCc1c2OC(=O)C=Cc2cc3ccoc13 PCWZKQSKUXXDDJ-UHFFFAOYSA-N 0.000 description 1
- 206010048245 Yellow skin Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 210000003489 abdominal muscle Anatomy 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 201000004484 acute conjunctivitis Diseases 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 201000007201 aphasia Diseases 0.000 description 1
- KZNIFHPLKGYRTM-UHFFFAOYSA-N apigenin Chemical compound C1=CC(O)=CC=C1C1=CC(=O)C2=C(O)C=C(O)C=C2O1 KZNIFHPLKGYRTM-UHFFFAOYSA-N 0.000 description 1
- 229940117893 apigenin Drugs 0.000 description 1
- XADJWCRESPGUTB-UHFFFAOYSA-N apigenin Natural products C1=CC(O)=CC=C1C1=CC(=O)C2=CC(O)=C(O)C=C2O1 XADJWCRESPGUTB-UHFFFAOYSA-N 0.000 description 1
- 235000008714 apigenin Nutrition 0.000 description 1
- 150000001491 aromatic compounds Chemical class 0.000 description 1
- ZZDWUECZDPGSPL-UHFFFAOYSA-N arteanoflavone Natural products COc1cc(cc(O)c1OC)-c1cc(=O)c2c(OC)c(OC)c(O)cc2o1 ZZDWUECZDPGSPL-UHFFFAOYSA-N 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 238000013475 authorization Methods 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 229960002045 bergapten Drugs 0.000 description 1
- KGZDKFWCIPZMRK-UHFFFAOYSA-N bergapten Natural products COC1C2=C(Cc3ccoc13)C=CC(=O)O2 KGZDKFWCIPZMRK-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000000039 congener Substances 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- KCFYHBSOLOXZIF-UHFFFAOYSA-N dihydrochrysin Natural products COC1=C(O)C(OC)=CC(C2OC3=CC(O)=CC(O)=C3C(=O)C2)=C1 KCFYHBSOLOXZIF-UHFFFAOYSA-N 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 239000013583 drug formulation Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 201000010582 ecthyma Diseases 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 208000001780 epistaxis Diseases 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 230000008921 facial expression Effects 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000003958 fumigation Methods 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- URINFYYBTXOQCT-UHFFFAOYSA-N gastrodioside Natural products OC1C(O)C(O)C(CO)OC1OC(C=C1)=CC=C1COCC1=CC=C(O)C=C1 URINFYYBTXOQCT-UHFFFAOYSA-N 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- -1 hydrogen farnesyl acetones Chemical class 0.000 description 1
- 230000001077 hypotensive effect Effects 0.000 description 1
- 208000022653 infective arthritis Diseases 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 210000002414 leg Anatomy 0.000 description 1
- 201000002364 leukopenia Diseases 0.000 description 1
- 231100001022 leukopenia Toxicity 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 210000003784 masticatory muscle Anatomy 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 229960004469 methoxsalen Drugs 0.000 description 1
- SQBBOVROCFXYBN-UHFFFAOYSA-N methoxypsoralen Natural products C1=C2OC(=O)C(OC)=CC2=CC2=C1OC=C2 SQBBOVROCFXYBN-UHFFFAOYSA-N 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 210000004237 neck muscle Anatomy 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 206010030899 opisthotonus Diseases 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 229960005489 paracetamol Drugs 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 210000003903 pelvic floor Anatomy 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 208000037920 primary disease Diseases 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 230000001047 pyretic effect Effects 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 210000003019 respiratory muscle Anatomy 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 208000005687 scabies Diseases 0.000 description 1
- 239000009490 scorpio Substances 0.000 description 1
- 230000036280 sedation Effects 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 206010040872 skin infection Diseases 0.000 description 1
- 239000002893 slag Substances 0.000 description 1
- 230000037321 sleepiness Effects 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 210000005070 sphincter Anatomy 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 235000013547 stew Nutrition 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 235000019605 sweet taste sensations Nutrition 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- BMCJATLPEJCACU-UHFFFAOYSA-N tricin Natural products COc1cc(OC)c(O)c(c1)C2=CC(=O)c3c(O)cc(O)cc3O2 BMCJATLPEJCACU-UHFFFAOYSA-N 0.000 description 1
- 210000001364 upper extremity Anatomy 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 201000002327 urinary tract obstruction Diseases 0.000 description 1
- 239000002435 venom Substances 0.000 description 1
- 231100000611 venom Toxicity 0.000 description 1
- 210000001048 venom Anatomy 0.000 description 1
- 239000009792 yinqiao Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/58—Reptiles
- A61K35/583—Snakes; Lizards, e.g. chameleons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/238—Saposhnikovia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/486—Millettia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/634—Forsythia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8988—Gastrodia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明是公开了一种预防破伤风的中药喷雾剂,各原料药如下,均为重量份:刘寄奴3-8,独角莲5-15,川防风1-5,血竭2-8,天麻6-12,野菊花11-18,独活6-13,大蓟5-13,连翘4-15,乌鞘蛇1-5,鸡血藤3-9,金银花2-7。该中药喷雾剂对预防破伤风的效果显著,不仅能够止痛,还能杀菌消炎,舒筋活血,最主要的是能预防和治疗破伤风,且本发明多选用地方常见药材,价格低廉,减轻了患者的经济负担。
Description
技术领域
本发明属中医中药领域,尤其是涉及一种预防破伤风的中药喷雾剂及其制备方法。
背景技术
破伤风是破伤风杆菌经由皮肤或黏膜伤口侵入人体,在缺氧环境下生长繁殖,产生毒素而引起阵发性肌痉挛的一种特异性感染。破伤风潜伏期通常为7~8天,可短至24小时或长达数月、数年。潜伏期短者,预后越差。约90%的患者在受伤后2周内发病,偶见患者在摘除体内存留多年的异物后出现破伤风症状。破伤风是常和创伤相关联的一种特异性感染。除了可能发生在各种创伤后,还可能发生于不洁条件下分娩的产妇和新生儿。病菌是破伤风梭菌,为专性厌氧,革兰染色阳性。平时存在于人畜的肠道,随粪便排出体外,以芽胞状态分布于自然界,尤以土壤中为常见。此菌对环境有很强的抗力,能耐煮沸。创伤伤口的污染率很高,战场中污染率可达25%~80%。但破伤风发病率只占污染者的1%~2%,提示发病必须具有其他因素,主要因素就是缺氧环境。创伤时,破伤风梭菌可污染深部组织(如盲管外伤、深部刺伤等)。如果伤口外口较小,伤口内有坏死组织、血块充塞,或填塞过紧、局部缺血等,就形成了一个适合该菌生长繁殖的缺氧环境。如果同时存在需氧菌感染,后者将消耗伤口内残留的氧气,使本病更易于发生。
破伤风潜伏期通常为7~8天,可短至24小时或长达数月、数年。潜伏期短者,预后越差。约90%的患者在受伤后2周内发病,偶见患者在摘除体内存留多年的异物后出现破伤风症状。前躯症状是全身乏力、头晕、头痛、咀嚼无力、局部肌肉发紧、扯痛、反射亢进等。典型症状是在肌紧张性收缩(肌强直、发硬)的基础上,阵发性强烈痉挛,通常最先受影响的肌群是咀嚼肌,随后顺序为面部表情肌、颈、背、腹、四肢肌,最后为膈肌。相应出现的征象为:张口困难(牙关紧闭)、蹙眉、口角下缩、咧嘴“苦笑”、颈部强直、头后仰;当背、腹肌同时收缩,因背部肌群较为有力,躯干因而扭曲成弓、结合颈、四肢的屈膝、弯肘、半握拳等痉挛姿态,形成“角弓反张”或“侧弓反张”;膈肌受影响后,发作时面唇青紫,通气困难,可出现呼吸暂停。上述发作可因轻微的刺激,如光、声、接触、饮水等而诱发。间隙期长短不一,发作频繁者,常示病情严重。发作时神志清楚,表情痛苦,每次发作时间由数秒至数分钟不等。强烈的肌痉挛,可使肌断裂,甚至发生骨折。膀胱括约肌痉挛可引起尿潴留。持续的呼吸肌和膈肌痉挛,可造成呼吸骤停。患者死亡原因多为窒息、心力衰竭或肺部并发症。病程一般为3~4周,如积极治疗、不发生特殊并发症者,发作的程度可逐步减轻,缓解期平均约1周。但肌紧张与反射亢进可继续一段时间;恢复期还可出现一些精神症状,如幻觉、言语、行动错乱等,但多能自行恢复。
授权公告号 CN 102940660 B(申请号 201210462633.5)的专利公开了一种治疗破伤风的中草药,其特征包括:(1) 该中草药每副的药材组成如下:千里光 0.5-4g,八角枫2-25g,六月雪1-10g,野菊花0.5-5g;(2) 该中草药的制备方法是:取上述药材洗净、切碎晒干,破碎制粉,按照每副药物配方的质量组成混合均匀,密封包装存于阴凉干燥处,得到成药备用;(3)该中草药的使用方法是:取包装的成药1 副放入锅中,加入5L 水,煮开10 分钟熬出药水,把药汤连同药渣一起倒入盆内,盆底置一垫,让患者受伤的肢体放在垫上;再用布盖住受伤肢体严,以患者能承受为准;先以药水蒸汽熏蒸患处直至水由烫变温,尔后将肢体患处放入药水中浸泡到药水全凉为止,1 天蒸洗3 次,1 副药反复加热使用,1 天1 副,直至痊愈。授权公告号 CN 102526393 B(申请号 201210011802.3)的专利公开了一种治疗破伤风的外敷中药,其特征在于:所述中药的原料为防风、荆芥、蝉蜕、金银花、金银花、白芍、独角莲、白术、全蝎、僵蚕、地龙、蜈蚣、独活、鸡血藤、半夏、天南星、威灵仙、穿山甲,上述中药原料的配比为5∶1∶1∶1∶1∶1∶1∶1∶1∶1∶1∶1∶1∶1∶2∶5∶1∶2。
发明内容
针对现有预防破伤风不足的现状,本发明的目的之一在于提供预防破伤风的中药喷雾剂,具有易吸收,杀菌效果好,止痛快的特点,并且它采用地方上较为常见的中药材作为原料,成本低廉。
本发明的另一目的就是提供上述中药喷雾剂的制备方法。
本发明的上述目的是通过以下技术方案来实现的:
预防破伤风的中药喷雾剂,各原料药如下,均为重量份:刘寄奴3-8,独角莲5-15,川防风1-5,血竭2-8,天麻6-12,野菊花11-18,独活6-13,大蓟5-13,连翘4-15,乌鞘蛇1-5,鸡血藤3-9,金银花2-7。
预防破伤风的中药喷雾剂,优选的方案是,各原料药如下,均为重量份:刘寄奴5-7,独角莲8-13,川防风2-4,血竭4-6,天麻8-10,野菊花13-15,独活8-11,大蓟8-10,连翘8-12,乌鞘蛇2-4,鸡血藤5-7,金银花4-6。
预防破伤风的中药喷雾剂,更佳优选的方案是,各原料药如下,均为重量份:刘寄奴6,独角莲10,川防风3,血竭5,天麻9,野菊花14,独活10,大蓟9,连翘10,乌鞘蛇3,鸡血藤6,金银花5。
上述中药喷雾剂的制备方法,制备步骤如下:
(1)将乌鞘蛇放入瓦罐内,兑入高粱酒,密封浸泡10-20小时,过滤,滤液备用,浸泡后的乌鞘蛇取出晾干待用;
(2)将刘寄奴,独角莲,川防风和血竭置于热锅内,炒至5-10分钟,与步骤(1)所得乌鞘蛇一同研磨成细末,过80-120目筛;
(3)将天麻、野菊花、独活、大蓟、连翘、鸡血藤和金银花洗净,浸泡20-40分钟,取出,置于案板上,切碎,与步骤(1)所得滤液混匀,稍闷20-40分钟后,加水煎煮2次,第一次武火煎开,转文火煎30-60分钟,过滤得滤液1,再次加水微火慢煎60-70分钟,过滤,得滤液2,将两次滤液合并,得混合滤液;
(4)将步骤(2)所得细末加入到步骤(3)所得混合滤液中,小火煎煮至沸腾,停火,静置1-2小时,取上清液装瓶即得中药喷雾剂。
前面所述的中药喷雾剂的制备方法,步骤(1)高粱酒的用量是乌鞘蛇总用量的8-12倍(优选的,高粱酒的用量是乌鞘蛇总用量的9-11倍,更佳优选的,高粱酒的用量是乌鞘蛇总用量的10倍)。
前面所述的中药喷雾剂的制备方法,步骤(1)兑入高粱酒,密封浸泡13-18小时(优选的,兑入高粱酒,密封浸泡15小时)。
前面所述的中药喷雾剂的制备方法,步骤(2)细末过90-110目筛(优选的,细末过100目筛)。
前面所述的中药喷雾剂的制备方法,步骤(3)稍闷25-35分钟后,加水煎煮2次(优选的,稍闷30分钟后,加水煎煮2次)。
前面所述的中药喷雾剂的制备方法,步骤(3)再次加水微火慢煎63-68分钟(优选的,再次加水微火慢煎65分钟)。
前面所述的中药喷雾剂的制备方法,步骤(4)静置1.3-1.8小时(优选的,静置1.5小时)。
使用方法:为使本发明达到最佳治疗效果,取本发明中药喷雾剂5-10ml,喷洒在伤口部位即可,严重的患者,可以适当的口服。
该中药喷雾剂对感染性关节炎的效果显著,不仅能够止痛,还能杀菌消炎,舒筋活血,最主要的是能预防破伤风,本发明多选用地方常见药材,价格低廉,减轻了患者的经济负担。
预防破伤风的中药喷雾剂,各原料药的药理功效分别为:
刘寄奴:又名刘寄奴草、九里光,为菊科蒿属植物奇蒿的带花全草。药性:茎圆柱形,表面棕黄色或棕绿色,质硬而脆,易折断,头状花序集成穗状圆锥花序,枯黄色,气芳香,味苦、辛,性温。成分:主要含有奇蒿黄酮、小麦黄素、芹菜素、棕榈酸等。根据现代药理研究发现,该药具有抗缺氧、活血化瘀、消积、止血消肿的功效,用于血滞经闭,食积腹痛,尿血,烫伤等症。
独角莲: 别名禹白附、牛奶白附、红男星、麻芋子、野半夏、鸡心白附。 性味功效 辛、甘,温。有毒。归胃,肝经。功能燥湿化痰,怯风止痉,解毒散剂结。适用于风痰滞络、口眼歪斜、中风痰盛、偏瘫失语、破伤风以及寒湿头痛;外用用于痰核瘰疬,毒蛇咬伤。
川防风:基原:为伞形科前胡属植物竹节前胡的根。成分:川防风发油含扣巴萜,十四酸,十六酸甲酯,六氢金合欢基丙酮,邻苯二甲酸二丁酯,十八酸等。药性:《四川中药志》1960年版:“性温,味甘、辛。入肺、脾、膀胱三经。”功用主治:《四川中药志》1960年版:“发表镇痛,祛风胜湿。治外感表征,头痛昏眩,关节疼痛,四肢居挛,目赤,疮疡及破伤风等症。
血竭,药名。别名:骐驎竭、海蜡、麒麟血、木血竭。药材基源:棕榈科植物麒麟竭果实和藤茎中的树脂。具有活血散瘀,定痛,止血生肌的功效。目前国产血竭多为百合科剑叶龙血树或柬埔寨龙血树树脂,进口血竭较为少见。散瘀定痛,止血生肌。治跌打折损,内伤瘀痛;外伤出血不止,瘰疬,臁疮溃久不合。
天麻:基原:为天科天麻属植物天麻的块茎。成分:天麻含酚类:天麻苷即称天麻素,天麻醚苷,4-乙氧甲基苯酚,对羟基苯甲醛,3,4-二羟基苯甲醛;芳香族化合物:4-羟苄基甲醚等。药性:甘、辛,平。归肝经。功用主治:熄风止痉,平肝阳,祛风通络。主治急慢惊风,抽搐拘挛,破伤风,眩晕,头痛,半身不遂,肢麻,风湿痹痛。
野菊花(学名:Dendranthema indicum)为菊科多年生草本植物,野菊花头状花序的外形与菊花相似,野生于山坡草地、田边、路旁等野生地带。以色黄无梗、完整、苦辛、花未全开者为佳。野菊花性微寒,具疏散风热、消肿解毒。能治疗疔疮痈肿、咽喉肿痛、风火赤眼、头痛眩晕等病证。
独活:独活,中药名,为伞形科植物重齿毛当归的干燥根。独活有抗炎、镇痛及镇静作用;对血小板聚集有抑制作用;并有降压作用,但不持久;所含香柑内酯、花椒毒素等有光敏及抗肿瘤作用。
大蓟:大蓟菊科、蓟属植物,蓟的全草或根,多年生草本,高0.5~1m。根簇生,圆锥形,肉质,表面棕褐色。茎直立,有细纵纹,基部有白色丝状毛。性凉,味甘,苦,无毒。归心、肝经。治吐血,衄血,尿血,血淋,血崩,带下,肠风,肠痈,痈疡肿毒,疔疮。
连翘:连翘落叶灌木,香港俗称一串金,是木犀科连翘属植物。入心、肝、胆、胃、三焦、大肠六经。清热,解毒,散结,消肿。治温热,丹毒,斑疹,痈疡肿毒,瘰疬,小便淋闭。
乌鞘蛇:乌梢蛇 ,俗称乌蛇、乌风蛇,为游蛇科乌梢蛇属体形较大的无毒蛇,甘,平。归肝经。祛风,通络,止痉。用于风湿顽痹,麻木拘挛,中风口眼歪斜,半身不遂,抽搐痉挛,破伤风,麻风疥癣,瘰疬恶疮。
鸡血藤:鸡血藤,本品为豆科植物密花豆(血风藤、三叶鸡血藤、九层风)的干燥藤茎。味苦微甘、性温,归肝、心、肾经;色赤入血,质润行散;具有活血舒筋,养血调经的功效;主治风湿痹痛,手足麻木,肢体瘫痪,月经不调,经行不畅,痛经,经闭,白细胞减少症。治疗风湿所致的腰膝关节疼痛、风湿痹痛、肢体麻木。
金银花:金银花 ,又名忍冬(学名:Lonicera japonica)。“金银花”一名出自《本草纲目》,由于忍冬花初开为白色,后转为黄色,因此得名金银花。药材金银花为忍冬科忍冬属植物忍冬及同属植物干燥花蕾或带初开的花。金银花自古被誉为清热解毒的良药。它性甘寒气芳香,甘寒清热而不伤胃,芳香透达又可祛邪。金银花既能宣散风热,还善清解血毒,用于各种热性病,如身热、发疹、发斑、热毒疮痈、咽喉肿痛等症,均效果显著。
本发明中药喷雾剂基于中医中药预防破伤风的原理。选用的中药药材有杀菌消炎、舒筋活血,止痛、防破伤风的功效,且造价低廉,长期使用亦不会造成患者的经济负担,是预防破伤风较为理想的药物。
具体实施方式
下面结合实施例和实验例详细说明本发明的技术方案,但保护范围不被此限制。
实施例1 预防破伤风的中药喷雾剂, 各原料药如下,均为重量份(每份取10g):刘寄奴3,独角莲5,川防风1,血竭2,天麻6,野菊花11,独活6,大蓟5,连翘4,乌鞘蛇1,鸡血藤3,金银花2。
上述预防破伤风的中药喷雾剂的制备方法,步骤是:
(1)将乌鞘蛇放入瓦罐内,兑入高粱酒,高粱酒的用量是乌鞘蛇总用量的8倍,密封浸泡10小时,过滤,滤液备用,浸泡后的乌鞘蛇取出晾干待用;
(2)将刘寄奴,独角莲,川防风和血竭置于热锅内,炒至5分钟,与步骤(1)所得乌鞘蛇一同研磨成细末,过80目筛;
(3)将天麻、野菊花、独活、大蓟、连翘、鸡血藤和金银花洗净,浸泡20分钟,取出,置于案板上,切碎,与步骤(1)所得滤液混匀,稍闷20分钟后,加水煎煮2次,第一次武火煎开,转文火煎30分钟,过滤得滤液1,再次加水微火慢煎60分钟,过滤,得滤液2,将两次滤液合并,得混合滤液;
(4)将步骤(2)所得细末加入到步骤(3)所得混合滤液中,小火煎煮至沸腾,停火,静置1小时,取上清液装瓶即得中药喷雾剂。
典型病例一 邹XX,男,40岁,黑龙江哈尔滨人士,农民,2006年9月28日,因腹部、腰背部疼痛7天伴有张口不便1天收入我院。一周前开始感到腹部、腰部、背部肌肉酸痛,全身困乏无力,双腿沉重,快步行走时,有上气不接下气的感觉。在当地卫生室按“感冒”使用了扑热息痛、维C银翘片,其症状无减轻。入院前曾经受过外伤,伤口没有很深,没有打破伤风的针,经过初步的观察发现,是破伤风。
使用实施例1所得中药喷雾剂,使用3天疼痛减轻,体力恢复;使用10天,疼痛消失,可以正常行走;继续使用10天作为巩固,停药至今无复发。
实施例2 预防破伤风的中药喷雾剂, 各原料药如下,均为重量份(每份取15g):刘寄奴8,独角莲15,川防风5,血竭8,天麻12,野菊花18,独活13,大蓟13,连翘15,乌鞘蛇5,鸡血藤9,金银花7。
上述预防破伤风的中药喷雾剂的制备方法,步骤是:
(1)将乌鞘蛇放入瓦罐内,兑入高粱酒,高粱酒的用量是乌鞘蛇总用量的12倍,密封浸泡20小时,过滤,滤液备用,浸泡后的乌鞘蛇取出晾干待用;
(2)将刘寄奴,独角莲,川防风和血竭置于热锅内,炒至10分钟,与步骤(1)所得乌鞘蛇一同研磨成细末,过120目筛;
(3)将天麻、野菊花、独活、大蓟、连翘、鸡血藤和金银花洗净,浸泡40分钟,取出,置于案板上,切碎,与步骤(1)所得滤液混匀,稍闷40分钟后,加水煎煮2次,第一次武火煎开,转文火煎60分钟,过滤得滤液1,再次加水微火慢煎70分钟,过滤,得滤液2,将两次滤液合并,得混合滤液;
(4)将步骤(2)所得细末加入到步骤(3)所得混合滤液中,小火煎煮至沸腾,停火,静置2小时,取上清液装瓶即得中药喷雾剂。
实施例3 预防破伤风的中药喷雾剂, 各原料药如下,均为重量份(每份取20g):刘寄奴5,独角莲8,川防风2,血竭4,天麻8,野菊花13,独活8,大蓟8,连翘8,乌鞘蛇2,鸡血藤5,金银花4。
上述预防破伤风的中药喷雾剂的制备方法,步骤是:
(1)将乌鞘蛇放入瓦罐内,兑入高粱酒,高粱酒的用量是乌鞘蛇总用量的9倍,密封浸泡13小时,过滤,滤液备用,浸泡后的乌鞘蛇取出晾干待用;
(2)将刘寄奴,独角莲,川防风和血竭置于热锅内,炒至7分钟,与步骤(1)所得乌鞘蛇一同研磨成细末,过90目筛;
(3)将天麻、野菊花、独活、大蓟、连翘、鸡血藤和金银花洗净,浸泡25分钟,取出,置于案板上,切碎,与步骤(1)所得滤液混匀,稍闷25分钟后,加水煎煮2次,第一次武火煎开,转文火煎40分钟,过滤得滤液1,再次加水微火慢煎63分钟,过滤,得滤液2,将两次滤液合并,得混合滤液;
(4)将步骤(2)所得细末加入到步骤(3)所得混合滤液中,小火煎煮至沸腾,停火,静置1.3小时,取上清液装瓶即得中药喷雾剂。
典型病例二朱XX,男,50 岁,工人, 2012 年9月的一天,因酒后不慎跌倒,被路边锈铁钉扎入右肘,几天后,右上肢红肿如脚小腿样,发热、剧痛、伸曲不得;诊断为破伤风。
使用实施例3所得中药喷雾剂,使用5天,不适症状有所缓解;使用10天,已可以下床行走,跛行症状基本消失;使用5天作为巩固,使用实施例3所得中药喷雾剂期间无任何副作用出现。
实施例4预防破伤风的中药喷雾剂, 各原料药如下,均为重量份(每份取25g):刘寄奴7,独角莲13,川防风4,血竭6,天麻10,野菊花15,独活11,大蓟10,连翘12,乌鞘蛇2-4,鸡血藤7,金银花6。
上述预防破伤风的中药喷雾剂的制备方法,步骤是:
(1)将乌鞘蛇放入瓦罐内,兑入高粱酒,高粱酒的用量是乌鞘蛇总用量的11倍,密封浸泡18小时,过滤,滤液备用,浸泡后的乌鞘蛇取出晾干待用;
(2)将刘寄奴,独角莲,川防风和血竭置于热锅内,炒至9分钟,与步骤(1)所得乌鞘蛇一同研磨成细末,过110目筛;
(3)将天麻、野菊花、独活、大蓟、连翘、鸡血藤和金银花洗净,浸泡35分钟,取出,置于案板上,切碎,与步骤(1)所得滤液混匀,稍闷35分钟后,加水煎煮2次,第一次武火煎开,转文火煎50分钟,过滤得滤液1,再次加水微火慢煎68分钟,过滤,得滤液2,将两次滤液合并,得混合滤液;
(4)将步骤(2)所得细末加入到步骤(3)所得混合滤液中,小火煎煮至沸腾,停火,静置1.8小时,取上清液装瓶即得中药喷雾剂。
实施例5预防破伤风的中药喷雾剂, 各原料药如下,均为重量份(每份取30g):刘寄奴6,独角莲10,川防风3,血竭5,天麻9,野菊花14,独活10,大蓟9,连翘10,乌鞘蛇3,鸡血藤6,金银花5。
上述预防破伤风的中药喷雾剂的制备方法,步骤是:
(1)将乌鞘蛇放入瓦罐内,兑入高粱酒,高粱酒的用量是乌鞘蛇总用量的10倍,密封浸泡15小时,过滤,滤液备用,浸泡后的乌鞘蛇取出晾干待用;
(2)将刘寄奴,独角莲,川防风和血竭置于热锅内,炒至8分钟,与步骤(1)所得乌鞘蛇一同研磨成细末,过100目筛;
(3)将天麻、野菊花、独活、大蓟、连翘、鸡血藤和金银花洗净,浸泡30分钟,取出,置于案板上,切碎,与步骤(1)所得滤液混匀,稍闷30分钟后,加水煎煮2次,第一次武火煎开,转文火煎45分钟,过滤得滤液1,再次加水微火慢煎65分钟,过滤,得滤液2,将两次滤液合并,得混合滤液;
(4)将步骤(2)所得细末加入到步骤(3)所得混合滤液中,小火煎煮至沸腾,停火,静置1.5小时,取上清液装瓶即得中药喷雾剂。
试验例1 实施例5所得预防破伤风的中药喷雾剂的临床应用:在4所医院筛选300例患者,试验之前1周,对该人群进行连续观察,记录症状及变化,随机分为两组,实验组及对照组,实验组200例,对照组100人,实验组使用实施例5所得中药喷雾剂,对照组使用其它药品(消炎镇痛膏、消炎生肌膏等常规预防破伤风的药品)。疗效情况判定标准:治愈:不适症状完全消失,有效:使用本品后,不适症状减轻或部分消失;无效:使用本品后,不适症状无变化。结果如表1所示。
表1:使用实施例5产品破伤风患者治疗结果
治疗效果:实验组治愈人数192例,临床显效6例,总有效率99%,实验组疗效明显高于对照组。
预防破伤风的中药喷雾剂,其中独角莲、野菊花和连翘联合作君,臣药为天麻、大蓟和大蓟,剩下的均为佐药;君药在本发明中承担着主治功效,均有止痛消炎、活血化瘀的功效;臣药是辅助君药加强治疗主病和主证的药物;佐药治疗兼症,减缓君药和臣药的烈性;使药起着药引的作用。
Claims (10)
1.一种预防破伤风的中药喷雾剂,其特征在于:各原料药如下,均为重量份:刘寄奴3-8,独角莲5-15,川防风1-5,血竭2-8,天麻6-12,野菊花11-18,独活6-13,大蓟5-13,连翘4-15,乌鞘蛇1-5,鸡血藤3-9,金银花2-7。
2.根据权利要求1所述的预防破伤风的中药喷雾剂,其特征在于:各原料药如下,均为重量份:刘寄奴5-7,独角莲8-13,川防风2-4,血竭4-6,天麻8-10,野菊花13-15,独活8-11,大蓟8-10,连翘8-12,乌鞘蛇2-4,鸡血藤5-7,金银花4-6。
3.根据权利要求1所述的预防破伤风的中药喷雾剂,其特征在于:各原料药如下,均为重量份:刘寄奴6,独角莲10,川防风3,血竭5,天麻9,野菊花14,独活10,大蓟9,连翘10,乌鞘蛇3,鸡血藤6,金银花5。
4.根据权利要求1-3任一项所述的中药喷雾剂的制备方法,其特征在于:步骤如下:
(1)将乌鞘蛇放入瓦罐内,兑入高粱酒,密封浸泡10-20小时,过滤,滤液备用,浸泡后的乌鞘蛇取出晾干待用;
(2)将刘寄奴,独角莲,川防风和血竭置于热锅内,炒至5-10分钟,与步骤(1)所得乌鞘蛇一同研磨成细末,过80-120目筛;
(3)将天麻、野菊花、独活、大蓟、连翘、鸡血藤和金银花洗净,浸泡20-40分钟,取出,置于案板上,切碎,与步骤(1)所得滤液混匀,稍闷20-40分钟后,加水煎煮2次,第一次武火煎开,转文火煎30-60分钟,过滤得滤液1,再次加水微火慢煎60-70分钟,过滤,得滤液2,将两次滤液合并,得混合滤液;
(4)将步骤(2)所得细末加入到步骤(3)所得混合滤液中,小火煎煮至沸腾,停火,静置1-2小时,取上清液装瓶即得中药喷雾剂。
5.根据权利要求4所述的中药喷雾剂的制备方法,其特征在于:步骤(1)高粱酒的用量是乌鞘蛇总用量的8-12倍(优选的,高粱酒的用量是乌鞘蛇总用量的9-11倍,更佳优选的,高粱酒的用量是乌鞘蛇总用量的10倍)。
6.根据权利要求4所述的中药喷雾剂的制备方法,其特征在于:步骤(1)兑入高粱酒,密封浸泡13-18小时(优选的,兑入高粱酒,密封浸泡15小时)。
7.根据权利要求4所述的中药喷雾剂的制备方法,其特征在于:步骤(2)细末过90-110目筛(优选的,细末过100目筛)。
8.根据权利要求4所述的中药喷雾剂的制备方法,其特征在于:步骤(3)稍闷25-35分钟后,加水煎煮2次(优选的,稍闷30分钟后,加水煎煮2次)。
9.根据权利要求4所述的中药喷雾剂的制备方法,其特征在于:步骤(3)再次加水微火慢煎63-68分钟(优选的,再次加水微火慢煎65分钟)。
10.根据权利要求4所述的中药喷雾剂的制备方法,其特征在于:步骤(4)静置1.3-1.8小时(优选的,静置1.5小时)。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410762968.8A CN104491491A (zh) | 2014-12-14 | 2014-12-14 | 一种预防破伤风的中药喷雾剂及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410762968.8A CN104491491A (zh) | 2014-12-14 | 2014-12-14 | 一种预防破伤风的中药喷雾剂及其制备方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN104491491A true CN104491491A (zh) | 2015-04-08 |
Family
ID=52933005
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410762968.8A Pending CN104491491A (zh) | 2014-12-14 | 2014-12-14 | 一种预防破伤风的中药喷雾剂及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN104491491A (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105963543A (zh) * | 2016-07-30 | 2016-09-28 | 郑树旺 | 一种治疗破伤风的中药制剂及制备方法 |
-
2014
- 2014-12-14 CN CN201410762968.8A patent/CN104491491A/zh active Pending
Non-Patent Citations (4)
Title |
---|
李学清: "玉真散治愈破伤风1例", 《上海中医药杂志》 * |
赵即民等: "独角莲对小白鼠实验破伤风的疗效观察", 《中国兽医学报》 * |
马汴梁: "玉真散验案三例", 《中原医刊》 * |
黄月明等: "中西医结合治疗破伤风", 《现代中西医结合杂志》 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105963543A (zh) * | 2016-07-30 | 2016-09-28 | 郑树旺 | 一种治疗破伤风的中药制剂及制备方法 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN104398934A (zh) | 一种用于皮肤瘙痒的中药组合物及其制备方法 | |
CN107496265A (zh) | 一种去屑止痒防脱中药洗发粉及其制备方法 | |
CN104069474A (zh) | 一种治疗脂溢性脱发的中药组合物及其制备方法 | |
CN104127813A (zh) | 一种治疗气血两虚型褥疮的中药组合物及其制备方法 | |
CN103933509A (zh) | 用于治疗淡水鱼水霉病的药物及其制备方法 | |
CN106491804A (zh) | 一种桶药浴之瑶娃娃浴粉及其制备方法 | |
CN104491376A (zh) | 一种治疗丘疹性荨麻疹的中药喷雾剂及其制备方法 | |
CN102552735A (zh) | 一种治疗便秘型臁疮的中药制备方法 | |
CN109350657A (zh) | 一种治疗风湿病的组合物、制备方法及其应用 | |
CN105412899A (zh) | 一种用于缓解红斑性肢痛病的中药制剂及其制备方法 | |
CN104324350A (zh) | 一种用于慢性结肠炎的中药组合物及其制备方法 | |
CN103655310A (zh) | 绿色染发剂 | |
CN107296935A (zh) | 一种治疗周围性面瘫的中药组合物及中药制剂 | |
CN104491491A (zh) | 一种预防破伤风的中药喷雾剂及其制备方法 | |
CN106421083A (zh) | 具有治疗风湿骨痛功效的瑶药保健浴包及其制备方法 | |
CN102949633B (zh) | 治疗便秘的中药组合物 | |
CN105663937A (zh) | 一种用于乳房湿疹的中药制剂及其制备方法 | |
CN106539947A (zh) | 儿童保健药浴包 | |
CN105596769A (zh) | 一种治疗烧烫伤、褥疮、痔疮的中药物 | |
CN104147480A (zh) | 一种止痛的外用中药组合物及其制备方法 | |
CN102961534A (zh) | 一种治疗精神分裂症发作期的中药组合物及其制备方法 | |
CN107375621A (zh) | 一种防治痛风的洗浴中草药组合物及其制备方法 | |
CN105998859A (zh) | 一种治疗肝胆湿热型胰腺炎的中药组合物 | |
CN105434313A (zh) | 一种具有美白、祛斑及抗皱作用的中药组合物 | |
CN104147481A (zh) | 一种止痒的外用中药组合物及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150408 |