CN109260362A - A kind of Chinese medicine composition and preparation method thereof - Google Patents
A kind of Chinese medicine composition and preparation method thereof Download PDFInfo
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- CN109260362A CN109260362A CN201811331545.5A CN201811331545A CN109260362A CN 109260362 A CN109260362 A CN 109260362A CN 201811331545 A CN201811331545 A CN 201811331545A CN 109260362 A CN109260362 A CN 109260362A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/52—Juglandaceae (Walnut family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8967—Lilium, e.g. tiger lily or Easter lily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Abstract
The present invention provides a kind of Chinese medicine compositions, belong to technical field of traditional Chinese medicines, the Chinese medicine composition includes the raw material of following parts by weight: 60~80 parts of Rehmannia glutinosa, 30~40 parts of lily, 10~20 parts of rock sugar, 10~20 parts of Semen sesami nigrum, 20~30 parts of walnut and 40~60 parts of water.Chinese medicine composition provided by the invention is while improving depression with anxiety, moreover it is possible to the effect of obtaining the more sweet mouthfeel of burnt odor, and also adding nourishing yin and supplementing blood.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of Chinese medicine composition and preparation method thereof.
Background technique
Anxiety disorder is common mental disorder, is presented without firm basis without clear objective objects and concrete idea
The mood on tenterhooks and frightened and restless of content, there are also vegetative nerve symptom and muscular tone and motility are uneasy.Anxiety disorder
It is divided into two kinds of forms of panic disorder and generalized anxiety disorder.In China, anxiety disorder has become the common disease and frequently-occurring disease of modern society,
Affect people's lives quality.With the continuous development of medicine, people in treatment anxiety disorder and adjust constitution side for Chinese medicine
The understanding in face is also constantly being deepened.But oral traditional Chinese medicine, especially taking traditional Chinese herbal decoction then is that many people are unwilling to receive,
Because of the mouthfeel of most of traditional Chinese herbal decoction and bad, the taste stimulation for having bitter, puckery, raw meat etc. not to be easily accepted by, these stimulations are easy to draw
The nausea and vomiting for playing pill taker, affect the group of the drug compliances difference such as going on smoothly for treatment, especially children, old man.
In the prior art in order to improve the mouthfeel of traditional Chinese herbal decoction, be usually added in traditional Chinese herbal decoction a certain proportion of auxiliary material be prepared into it is solid
Body preparation.Do not find that Chinese medicine composition how in the case where not being prepared into traditional Chinese herbal decoction, can improve it also in the prior art
Mouthfeel, and the Chinese medicine composition of its drug effect is not influenced.
Summary of the invention
In view of this, the purpose of the present invention is to provide a kind of Chinese medicine composition, while improving depression with anxiety,
The effect of mouthfeel that more burnt odor is sweet can also be obtained, and also add nourishing yin and supplementing blood.
In order to achieve the above-mentioned object of the invention, the present invention the following technical schemes are provided:
The present invention provides a kind of Chinese medicine compositions, are prepared by the raw material for including following parts by weight:
60~80 parts of Rehmannia glutinosa；
30~40 parts of lily；
10~20 parts of rock sugar；
10~20 parts of Semen sesami nigrum；
20~30 parts of walnut；
40~60 parts of water.
Preferably, the Chinese medicine composition is by including that the raw material of following parts by weight is prepared:
70 parts of Rehmannia glutinosa；
35 parts of lily；
15 parts of rock sugar；
15 parts of Semen sesami nigrum；
25 parts of walnut；
50 parts of water.
The present invention provides the preparation methods of Chinese medicine composition described in above-mentioned technical proposal, comprising the following steps:
(1) Rehmannia glutinosa as described in the above technical scheme, lily, rock sugar and water mixed, steamed, obtain steaming object, institute
Stating the time steamed is 30~50min；
(2) walnut as described in the above technical scheme and Semen sesami nigrum are fried to the fragrance that discharges of the coke, obtains frying object；
(3) it steams object by what the step (1) obtained and is mixed with the frying object that step (2) obtains, obtain Chinese medicine composition.
The step (1) and (2) are limited without time sequencing.
Preferably, the time steamed is 35~45min.
Preferably, the length of the Rehmannia glutinosa, width and height are independently 0.5~1.5cm.
Preferably, the length of the Rehmannia glutinosa, width and height are independently 1cm.
Preferably, the lily is lily root flour, and the partial size of the lily root flour is less than 420 μm.
In Chinese medicine composition provided by the invention, Rehmannia glutinosa is monarch drug in a prescription, has the effect of enriching yin of enriching blood, beneficial to spirit and marrow, lily
For ministerial drug, can antitoxic heart-soothing and sedative, moistening lung and clearing away the heart-fire, the two can effectively treat breakdown of the normal physiological coordination between the heart and the kidney, and type of deficiency of both the heart and spleen anxiety disorder is equipped with Semen sesami nigrum
The effect of increasing its nourishing yin and nourishing blood with walnut simultaneously improves mouthfeel.
The embodiment of the present invention is as the result is shown: Chinese medicine composition provided by the invention can not only improve depressive anxiety disease
Shape, but also the mouthfeel sweet with burnt odor, are conducive to the promotion and popularization of product.
Specific embodiment
The present invention provides a kind of Chinese medicine compositions, are prepared by the raw material for including following parts by weight: Rehmannia glutinosa 60
~80 parts；30~40 parts of lily；10~20 parts of rock sugar；10~20 parts of Semen sesami nigrum；20~30 parts of walnut；40~60 parts of water.
It is 60~80 parts of Rehmannia glutinosa that Chinese medicine composition provided by the invention, which includes parts by weight, preferably 65~75 parts,
More it is selected as 70 parts.The present invention is not particularly limited the source of the Rehmannia glutinosa, using conventional commercial product.
In the present invention, the length of the Rehmannia glutinosa, width and the independent preferably 0.5~1.5cm of height, more preferably
0.8~1.2cm, most preferably 1cm.In the present invention, the Rehmannia glutinosa can enhance sweet taste, and the function with nourishing yin and supplementing blood
Effect.
It is 30~40 parts of lily that Chinese medicine composition provided by the invention, which includes parts by weight, preferably 32~38, it is more excellent
It is selected as 35 parts.The present invention is not particularly limited the source of the lily, using conventional commercial product.
In the present invention, the lily is preferably lily root flour, and the partial size of the lily root flour is preferably smaller than 420 μm, more preferably
Less than 380 μm, more preferably less than 360 μm.In the present invention, the lily has effects that heart clearing, lung moistening qi-restoratives.
It is 10~20 parts of rock sugar that Chinese medicine composition provided by the invention, which includes parts by weight, preferably 12~18 parts, more
Preferably 15 parts.The present invention is not particularly limited the source of the rock sugar, using conventional commercial product.
It is 10~20 parts of Semen sesami nigrum that Chinese medicine composition provided by the invention, which includes parts by weight, preferably 12~18 parts,
More preferably 15 parts.The present invention is not particularly limited the source of the Semen sesami nigrum, using conventional commercial product.At this
In invention, the Semen sesami nigrum not only has effects that nourishing yin and supplementing blood, and has improvement mouthfeel, mitigates the effect of drug dose.
It is 20~30 parts of walnut that Chinese medicine composition provided by the invention, which includes parts by weight, preferably 22~28 parts, more
Preferably 25 parts.The present invention is not particularly limited the source of the walnut, using conventional commercial product.In this hair
In bright, the walnut not only has effects that nourishing yin and supplementing blood, and has improvement mouthfeel, mitigates the effect of drug dose.
Chinese medicine composition provided by the invention includes the water that parts by weight are 40~60 parts, preferably 45~55 parts, more excellent
It is selected as 50 parts.
Water of the present invention is preferably pure water.
The present invention also provides the preparation methods of the Chinese medicine composition described in above-mentioned technical proposal, comprising the following steps:
(1) Rehmannia glutinosa, lily described in above-mentioned technical proposal, rock sugar and water mixed, steamed, obtain steaming object, it is described
The time steamed is 30~50min；
(2) walnut described in above scheme and Semen sesami nigrum are fried to the fragrance that discharges of the coke, obtains frying object；
(3) it steams object by what the step (1) obtained and is mixed with the frying object that step (2) obtains, obtain Chinese medicine composition.
The step (1) and (2) are limited without time sequencing.
Rehmannia glutinosa, lily described in above-mentioned technical proposal, rock sugar and water are mixed, are steamed by the present invention, obtain steaming object, institute
Stating the time steamed is 30~50min.
In the present invention, the Rehmannia glutinosa mouthfeel is sticky, lily grittiness sense, the delicate mouthfeel after steaming.
In the present invention, the time steamed is 30~50min, preferably 35~45min, more preferably 40min.
The present invention fries walnut and Semen sesami nigrum described in above-mentioned technical proposal to the fragrance that discharges of the coke, and obtains frying object.
The present invention is not particularly limited the frying condition of walnut and Semen sesami nigrum, and frying has burnt odor gas, cannot be charred.
The present invention mixes the obtained object that steams with obtained frying object, obtains Chinese medicine composition.
In the present invention, the Chinese medicine composition that obtains is preferably solid paste.
Below in conjunction with the embodiment in the present invention, to a kind of Chinese medicine composition provided by the invention and preparation method thereof
Technical solution is clearly and completely described.Obviously, described embodiments are only a part of the embodiments of the present invention, without
It is whole embodiments.Based on the embodiments of the present invention, those of ordinary skill in the art are not before making creative work
Every other embodiment obtained is put, shall fall within the protection scope of the present invention.
Embodiment 1
(1) the Rehmannia glutinosa 60g of each 0.5cm of length, width and height, lily root flour 30g, rock sugar 10g and water 40g mixed, steamed, obtained
Object is steamed, the time steamed is 30min；
(2) walnut 20g and Semen sesami nigrum 10g are fried to the fragrance that discharges of the coke, obtains frying object；
(3) it steams object by what step (1) obtained and is mixed with the frying object that step (2) obtains, obtain Chinese medicine composition, Chinese medicine
Composition is solid paste.
Step (1) and (2) are limited without time sequencing.
Embodiment 2
(1) the Rehmannia glutinosa 70g of each 1.0cm of length, width and height, lily root flour 35g, rock sugar 15g and water 50g mixed, steamed, obtained
Object is steamed, the time steamed is 40min；
(2) walnut 25g and Semen sesami nigrum 15g are fried to the fragrance that discharges of the coke, obtains frying object；
(3) it steams object by what step (1) obtained and is mixed with the frying object that step (2) obtains, obtain Chinese medicine composition, Chinese medicine
Composition is solid paste.
Step (1) and (2) are limited without time sequencing.
Embodiment 3
(1) the Rehmannia glutinosa 80g of each 1.5cm of length, width and height, lily root flour 40g, rock sugar 20g and water 60g mixed, steamed, obtained
Object is steamed, the time steamed is 50min；
(2) walnut 30g and Semen sesami nigrum 20g are fried to the fragrance that discharges of the coke, obtains frying object；
(3) it steams object by what step (1) obtained and is mixed with the frying object that step (2) obtains, obtain Chinese medicine composition, Chinese medicine
Composition is solid paste.
Step (1) and (2) are limited without time sequencing.
Embodiment 4
Chinese medicine composition antianxiety zoopery prepared by embodiment 3
1. the foundation of animal packet and anxiety disorder model
SPF grades of SD rats of 72 males, weight are 180~220g, are provided by Henan Province's animal experimental center.Experiment is dynamic
Object is tested after adapting to 1 week under experimental situation.Animal is randomly divided into 6 groups, every group 10.Respectively prepared by embodiment 3
The high, medium and low dosage group of Chinese medicine composition, model group, positive control diazepam injection group and blank group.Experimental animal removes normal group
Outside, remaining group timing water supply training 7d, i.e., daily only in 9:30~9:40 and 16:00~16:10 water supply.Later using uncertain
Empty bottle drinking-water stimulating method replicates anxiety disorder rat model, and carrying out uncertain empty bottle drinking-water in above-mentioned two period stimulates,
Stimulation is primary daily, continues 14 days.
2. animal is administered
Empty bottle, which stimulates the 8th day, to be started, and is administered to rat.Blank group and model group stomach-filling physiological saline, diazepam injection
Group stomach-filling diazepam medicine 2.5mg/Kg.d, Chinese medicine composition high, medium and low group of difference feeding 300g/ in ground prepared by embodiment 3
Kg.d, 200g/Kg.d, 100g/Kg.d (3 pieces, 2 pieces and 1 piece of Chinese medicine composition for being respectively equivalent to the preparation of embodiment 3).Continuously
30d is administered.During administration, Chinese medicine composition prepared by embodiment 3 is dissolved into suspension with distilled water, gives by several times daily.It makes
Its behaviouristics is evaluated using spacious field experiment and elevated plus-maze test after the completion of mould administration.
3 Behavior tests
Laboratory is rather dark (be subject to 1.5m distance at can distinguish the subtle movable minimum brightness of mouse), keeps permanent
It is bright, it 20~22 DEG C of room temperature, keeps quite.
3.1 elevated plus-maze models (EPM)
Every rat is put into a plastic casing (60cm × 60cm × 35cm) before test, is allowed to after freely probing into 5min
It is put in the center of EPM rapidly, makes its head face wherein open arms, the survey of tetra- indexs of OT, OE, CE, CT is carried out after release
It is fixed.Every rat tests 5min, removes animal traces with 10% ethanol solution wiping labyrinth therebetween, then cleaned with dry cloth, then
Carry out the measurement of next rat.Wherein the measurement of behavioral indexes is as follows:
(1) enter open arms time (OT): into the time of open arms, unit: second.
(2) enter open arms number (OE): entering the number of any open arms, enter arm with four claws of rat
Subject to interior, one claw in midway exits completely from the arm then enters activity completion for this time.
(3) enter closure arm number (CE): entering the number of any closure arm, enter arm with four claws of mouse
Subject to interior.
(4) enter closure arm time (CT): into the time of closure arm, unit: second.
Open arms time percentage: OT%=OT/ (OT+CT) × 100%
Open arms number percentage: OE%=OE/ (OE+CE) × 100%
The experiment of 3.2 rat light and shade casees
3.2.1 Behavior test
Mouse is put into a plastics to open in case, is allowed to be immediately placed in the camera-lucida of light and shade case after freely probing into, be used after release
Counter records interior mouse and wears case number.Centre wipes labyrinth with wet cloth, removes excrement, carries out down again after being cleaned with dry cloth
The test of one mouse.
3.2.2 behavioral indexes
Mouse wears case number: number of pass times of the mouse between camera-lucida and camera bellows.
The mouse camera-lucida time: mouse is in camera-lucida residence time.
4. data processing
Experimental data carries out one-way analysis of variance using 20.0 statistical software of SPSS, as a result with mean ± standard deviation
(× ± s) it indicates, wherein indicating the standard with significant difference with P < 0.05.
5. experimental result
1 Chinese medicine composition of table enters the influence of Elevated plus-maze open arms time, number percentage to mouse
| Group | n | Dosage | OT% | OE% |
| Blank group | 10 | — | 4.28±2.19 | 13.02±1.92 |
| Diazepam group (positive control) | 10 | 2.5mg/Kg | 10.24±2.12* | 23.22±3.93** |
| Chinese medicine composition (low dosage) | 10 | 100g/Kg | 9.15±1.93 | 18.95±1.57 |
| Chinese medicine composition (middle dosage) | 10 | 200g/Kg | 8.69±2.79 | 22.83±1.68** |
| Chinese medicine composition (high dose) | 10 | 300g/Kg | 7.23±1.50 | 20.68±2.19** |
Note: compared with the control group, * represents P < 0.05, and * * represents P < 0.01
2 Chinese medicine composition of table wears the influence of case number to mouse light and shade case
| Group | n | Dosage | Wear case number |
| Blank group | 10 | — | 17.5±3.8 |
| Diazepam group (positive control) | 10 | 2.5mg/Kg | 30.5±10.6** |
| Chinese medicine composition (low dosage) | 10 | 100g/Kg | 20.8±5.3 |
| Chinese medicine composition (middle dosage) | 10 | 200g/Kg | 22.9±9.8* |
| Chinese medicine composition (high dose) | 10 | 300g/Kg | 25.1±8.6* |
Note: compared with the control group, * represents P < 0.05, and * * represents P < 0.01
From the above experimental results, we know that Chinese medicine composition provided by the invention to the mouse elevated plus-maze open arms time,
The influence of number percentage, middle dose group result is optimal, is weaker than positive controls but is significantly higher than blank group.High dose group can be bright
Aobvious raising mouse wears camera bellows number, is significantly higher than blank group but is slightly weaker than positive controls.Therefore, Chinese medicine provided by the invention
Composition has certain angst resistance effect, though effect is weaker than diazepam, as a kind of health food, can be used as antianxiety
Effective supplement of drug.
As can be seen from the above embodiments, Chinese medicine composition provided by the invention can effectively prevent depression with anxiety,
Effect is obvious.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also answered
It is considered as protection scope of the present invention.
Claims (7)
1. a kind of Chinese medicine composition is prepared by the raw material for including following parts by weight:
60~80 parts of Rehmannia glutinosa；
30~40 parts of lily；
10~20 parts of rock sugar；
10~20 parts of Semen sesami nigrum；
20~30 parts of walnut；
40~60 parts of water.
2. Chinese medicine composition according to claim 1, which is characterized in that by the raw material preparation including following parts by weight
At:
70 parts of Rehmannia glutinosa；
35 parts of lily；
15 parts of rock sugar；
15 parts of Semen sesami nigrum；
25 parts of walnut；
50 parts of water.
3. a kind of preparation method of Chinese medicine composition of any of claims 1 or 2, comprising the following steps:
(1) Rehmannia glutinosa of any of claims 1 or 2, lily, rock sugar and water mixed, steamed, obtain steaming object, it is described to steam
Time be 30~50min；
(2) walnut of any of claims 1 or 2 and Semen sesami nigrum are fried to the fragrance that discharges of the coke, obtains frying object；
(3) it steams object by what the step (1) obtained and is mixed with the frying object that step (2) obtains, obtain Chinese medicine composition.
The step (1) and (2) are limited without time sequencing.
4. preparation method according to claim 3, which is characterized in that the time steamed is 35~45min.
5. preparation method according to claim 3, which is characterized in that length, width and the height of the Rehmannia glutinosa are independently
It is 0.5~1.5cm.
6. preparation method according to claim 5, which is characterized in that length, width and the height of the Rehmannia glutinosa are independently
It is 1cm.
7. preparation method according to claim 3, which is characterized in that the lily is lily root flour, the grain of the lily root flour
Diameter is less than 420 μm.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112426429A (en) * | 2020-11-19 | 2021-03-02 | 河南中医药大学 | Carbohydrate composition for nourishing yin and supplementing blood for yin and blood deficiency syndrome |
| CN112494502A (en) * | 2020-11-19 | 2021-03-16 | 河南中医药大学 | Saccharide composition for enriching blood of blood deficiency syndrome |
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| CN101062260A (en) * | 2007-06-05 | 2007-10-31 | 河南中医学院 | Granule for complementing Yin and preventing anxiety |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112426429A (en) * | 2020-11-19 | 2021-03-02 | 河南中医药大学 | Carbohydrate composition for nourishing yin and supplementing blood for yin and blood deficiency syndrome |
| CN112494502A (en) * | 2020-11-19 | 2021-03-16 | 河南中医药大学 | Saccharide composition for enriching blood of blood deficiency syndrome |
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Application publication date: 20190125 |