CN1092519C - Chinese medicine for argiitis - Google Patents
Chinese medicine for argiitis Download PDFInfo
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- CN1092519C CN1092519C CN98110202A CN98110202A CN1092519C CN 1092519 C CN1092519 C CN 1092519C CN 98110202 A CN98110202 A CN 98110202A CN 98110202 A CN98110202 A CN 98110202A CN 1092519 C CN1092519 C CN 1092519C
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Abstract
The present invention discloses a medicine composition for treating angitis, which belongs to the technical field of medicines. The present invention is composed of 0.5 to 2.5 portions of toad venom, 50 to 170 portions of pangolins, 30 to 120 portions of leeches, 10 to 50 portions of red lead, and is made into various medicine dosage types by common medicine excipient and conventional pharmaceutical technologies. The medicine of the present invention is proved to be safe after tested with acute toxicity on animals. The present invention has favorable healing rate and effect by clinical observation, and has better popularization value.
Description
The present invention relates to medical technical field, relate in particular to the vasculitic Chinese patent medicine of a kind of treatment.
Vasculitis is referred to as one of difficult disease of current medical circle, though this disease is difficult to jeopardize the human life, but cause animally to the patient easily and immeasurable mentally misery, because of there not being real clinical medicine at present, cure rate is extremely low, great majority are finally saved bigger disease from damage with the medical procedure of taking amputation and are tormented, thereby what bring to the patient is lifelong misery.From present clinical medicine, mainly be to use medicines such as FUFANG DANSHEN PIAN (capsule), Radix Salviae Miltiorrhizae Injection, snake venom antithrombotic enzyme, delay the amputation time by Therapeutic Principle such as blood vessel dilating, antiplatelet cohesions, thereby the performance in therapeutic process be the time long, curative effect is slow, expense is high, relapse rate is high, side effect is big, therefore seek the vasculitic medicine of a kind of treatment, particularly Chinese patent medicine has been pressing for treatment this disease of vasculitis.
The objective of the invention is in order to improve the deficiency of prior art, a kind of to have curative effect fast and provide, and treatment time is short, and expense is low, controls the Chinese patent medicine that is exclusively used in treatment vasculitis disease that the back does not have recurrence.
The objective of the invention is to be achieved by the following technical programs, the vasculitic pharmaceutical composition of a kind of treatment, its composition is:
Venenum Bufonis 0.5-2.5 part, Squama Manis 50-170 part, Hirudo 30-120 part, Plumbum preparatium 10-50 part
The preferable amount proportioning of said components is:
Venenum Bufonis 1-2 part, Squama Manis 80-120 part, Hirudo 50-100 part, Plumbum preparatium 20-35 part
The optimum weight proportioning of pharmaceutical composition of the present invention is:
1.5 parts of Venenum Bufoniss, 100 parts of Squama Maniss, 80 parts of Hirudos, 30 parts of Plumbum preparatiums
Above-mentioned pharmaceutical composition can be equipped with medicine excipient commonly used according to the Chinese medicine preparation technology of routine and be prepared into clinically common formulations, for example any pharmaceutical dosage forms commonly used such as pill, powder, tablet, sugar coated tablet, sublimed preparation, capsule.
Thromboangiitis obliterans is a kind of pernicious thrombus disease, it is the systemic disease that tremulous pulse and vein are got involved simultaneously, and can cause the generation of other disease, theory of Chinese medical science is thought: direct stimulation, impairment caused by overstrain are excessive, can make heart kidney two lose deficiency of heart-blood, the blood vessels operation is not smooth, the loss of kidney water, fire is high partially mutually, and the imbalance of heart kidney takes place, insufficiency of primordial QI, so that the imbalance of the four stages in the course of an epidemic febrile disease fortuneization, can not loose is skillful in blood vessels, and gradually forms deficiency of both QI and blood, adding cold again endures cold, the cold-evil is dissolved in meridians, and makes coagulation of QI-blood, and yang-energy can not be assigned and fall ill.
The effect of medicine of the present invention is: Venenum Bufonis is warm in nature, and the sweet in the mouth suffering is poisonous, has removing toxic substances and promoting subsidence of swelling, and pain relieving is had one's ideas straightened out, and the effect of topical anesthesia cures mainly carbuncle poison furuncle, diseases such as laryngopharynx swelling and pain, and external application or take medicine orally all can; The Squama Manis cold nature, salty in the mouth has eliminating stasis and resolving masses, and the eliminating carbuncle evacuation of pus is to draw prescribe medicine simply, penetrates meridians, through sick institute; Hirudo property is flat, the salty in the mouth hardship, and slightly poisonous, it is strong to have removing blood stasis power, and dissipating blood stasis to promote menstruationg cures mainly the blood stasis amenorrhea, lump in the abdomen, diseases such as blood-retention are liked anthropophagy's blood most and property is slow because of Hirudo, and slow then hemopoietic is not hindered, and is apt to borrow its power, to attack its stasis of accumulating in the course of time into then hard long-pending easily broken; The Plumbum preparatium is cold in nature, and is poisonous, has detoxifcation, blood stasis dispelling, the effect of granulation promoting.The overall efficacy of pharmaceutical composition of the present invention is: strengthening heart and boosting pressure, vigorous blood circulation, the formation of anticoagulation, thrombosis can blood vessel dilating, blood fat reducing, blood viscosity lowering, effect with convergence, sterilization, detumescence, granulation promoting has inhibitory action to Jia Xingrongxuexinglianqiujun, staphylococcus aureus, and is inhibited to platelet aggregation, can make it to leukocytic minimizing, can improve cellular immunization and humoral immune function.Show according in vitro tests: this medicine can make the setting time of fibrin stock solution prolong, and effect of antithrombase sample and the effect of urokinase sample are arranged, and makes the activation of fibrin solution.
The test example
(1) animal toxicity test
Venenum Bufonis, Hirudo, Plumbum preparatium are all poisonous medicine in the present invention's prescription, and single uses people's death by poisoning is died, but the synthetic toxicity that can make of four Chinese medicine active ingredient reduces in this programme, and the cumulative action of lead ion reduces.According to the learning centre publish high clear stricture of vagina comrade chief editor that Du publishes " put down in writing in the clinical handbook of practical toxic herb: Venenum Bufonis to the LD50 (mg/kg) of white mice is: intravenous injection 41.0, subcutaneous injection 96.60, lumbar injection 36.24, Hirudo is to female white mice subcutaneous injection Hirudo decoct, LD50 is 15.24g/kg, toxic dose 15-30g for oral administration, and the Plumbum preparatium is 16.70g/kg to the quiet crisp injection LD50 of mice, the LD50 of rat abdominal cavity administration is 220mg/kg, and animal toxicity test is:
1, acute toxicity test
(1) oral medication:
1. getting medicine 2g of the present invention adds water and grinds and to make full dose become the homogenate (concentration is 50mg/ml) of 40ml standby.
2. get 20 of white mice (each 10 of male and female), every white mice gives the equal serosity 0.02ml/g of sample according to the weight and irritates stomach (being equivalent to 1000mg/kg), observed 10 days, the all healthy existence of white mice, there is not any toxicity, through anatomic observation hemogram, liver function, each organs and tissues morphology finding and matched group be zero difference relatively.This product to the oral dosis tolerata of white mice more than 1000mg/kg.
3. get 20 of white mice (each 10 of male and female), every white mice according to the weight respectively grouping (10 every group) give the equal serosity 0.03ml/g of sample and 0.04ml/g and irritate stomach and (be equivalent to 1500mg/kg respectively, 2000mg/kg), observed 10 days, irritate all healthy existence of white mice of stomach 0.03ml/g group, no toxicity, through the anatomic observation hemogram, liver function, each organs and tissues morphology finding and matched group be zero difference relatively, the white mice of irritating stomach 0.04ml/g group showed the dysphoria of the degree of having nothing in common with each other in 10 days, stupor, wherein dead 2, account for 20%, unusual through the anatomic observation routine blood test, lead content in urine is slightly high, and liver function is normal, other each organs and tissues no abnormality seen, find other pneumorrhagia during 2 white mice of death are dissected, this shows medicine of the present invention to the oral maximum tolerated dose of white mice at 1500mg/kg, to the LD of mice) 50 (mg/kg) are 2000.
2 accumulation toxicity tests
(1) mouth medication:
1. getting medicine 1g of the present invention adds water and grinds and to make full dose become the homogenate (concentration is 25mg/ml) of 40ml standby.
2. get 40 of white mice (each 20 of male and female), every white mice gives the equal serosity 0.02ml/g of sample according to the weight and irritates stomach (being equivalent to 500mg/kg) once a day, observed three months, the all healthy existence of white mice, there is not any toxicity, through anatomic observation hemogram, liver function, each organs and tissues morphology finding and matched group be zero difference relatively, does not have substantially in the body and accumulates.
Show through toxicity test, this medicine is at 1500mg/kg to the maximum tolerated dose of mice, to the LD50 of mice more than 2000mg/kg, the accumulation toxicity test of mice is shown that the oral dose of 500mg/kg does not have to be accumulated, being higher than clinical program adult consumption is 400mg, child's consumption is 150mg, and unsuitable for children below three years old is taken, and this medicine is safe to the patient.
The clinical practice of medicine of the present invention:
Medicine of the present invention carries out clinical practice in 6 tame hospitals to vasculitis disease patient, receives altogether treatment patient 356 people, the elder of sick time 42 years, the shortest has 6 months, what treatment time was the longest is 60 days, and the shortest is 20 days, wherein Quan Yu 326 people, account for 91.6%, 25 people of produce effects account for 7%, 5 invalid people, account for 1.4%, total effective rate reaches 98.6%.Through to the following up a case by regular visits to of patient after curing, patient's complete recovery of health, work identical with the normal person do not found because of taking any untoward reaction that this medicine produces during the treatment.Now take passages typical case history as follows:
1, open * *, man, 76 years old, the Mouping District people of Yantai City, Shandong Province, first visit on May 28 in 1993, patient's self-induction paroxysmal pain had 8 years, and the ant sense is obvious, ulcus cruris, night severe pain unbearably, life is rough to take care of oneself, and repeatedly arrives hospital therapy, effect is always not obvious, is the biped vasculitis after diagnosing, through taking medicine of the present invention (each 400mg, every day three times), pain disappears after 5 days, recovery from illness in 20 days, so far follow up a case by regular visits to, do not have any recurrence and untoward reaction, still can engage in physical work.
2, grandson * * man, 36 years old, Shandong Province Laiyang City people, the 16 order first visits of patient's nineteen ninety-five JIUYUE, readme had two red lines, swelling pain in the left leg inboard before 3 years, disappear through the hospital treatment red line, after this left foot thumb begins pain, after this uninterruptedly takes relevant medicine 3 years, symptom fails to alleviate all the time, and the pain increased, the necrosis of left foot big toe, toenail comes off, other toenail yellowing, thickening, do not grow, YANG pulse is looked in the left leg atrophy, the Taixi arteries and veins disappears, yellowish fur, and complexion is sallow, lackluster, be diagnosed as three stage angiitis, through taking the 3rd day pain relief of medicine of the present invention (each 400mg, every day three times), pain almost disappears after 10 days, pulse recovers gradually, treats that sequestrum comes off automatically after 20 days, recovery from illness in 55 days. follow up a case by regular visits to so far patient body in order, do not see any untoward reaction, and with making us the same physical work of engaging in.
3, woods * *, the man, 66 years old, people from Haiyang City, Shandong Province, first visit on June 12 in 1996, patient's readme is cut sufficient heel by colter when farming operation in 1972, secondary infection is after hospitalize recovery from illness; Next year recurrence, state of an illness aggravation, left leg by amputation to knee joint. the modern state of an illness increases the weight of, lower limb pain unbearably, the yellow scab thickening blackening of amputation site and harden the serious atrophy of right lower limb, skin dimness, blackout and nonelastic, look a cun GUAN-pulse weak pulse stringy and thready pulse, this patient's lethargy, One's face was like wax, deep red tongue, through taking medicine of the present invention pain disappearance after (each 400mg, every day three times) 10 days, two limb colors were recovered gradually in 30 days, muscle begins flexible, recovery from illness after taking medicine 60 days, life can take care of oneself, and follows up a case by regular visits to so far, patient body is normal, and untoward reaction and not easypro sense are not arranged.
Describe a kind of specific embodiments for the treatment of vasculitic Chinese patent medicine of the present invention below in detail.
Embodiment 1
Take by weighing Venenum Bufonis 0.5kg, Squama Manis 50kg, Hirudo 30kg, Plumbum preparatium 10kg makes sugar coated tablet 90.5 * 10 with conventional pharmaceutical technology after pulverizing, sieving
4Sheet (every 0.1g) promptly obtains the sugar coated tablet of medicine of the present invention, and packs with little glass medicine bottle, every bottled 100.
Embodiment 2
Take by weighing Venenum Bufonis 2.5kg, Squama Manis 170kg, Hirudo 120kg, Plumbum preparatium 50kg adds 3 kilograms of Mel again as the medicine excipient after pulverizing, sieving, and to make quantity be 172.75 * 10 by producing the conventional pharmaceutical technology of pill or sublimed preparation
4Individual pill (every ball 0.2g) or to make quantity be 345.5 * 10
4Individual medicine pellet (every red 0.1g) promptly obtains pill, the sublimed preparation of medicine of the present invention, and packs with vial.
Embodiment 3
Take by weighing Venenum Bufonis 1kg, Squama Manis 80kg, Hirudo 50kg, Plumbum preparatium 20kg through crushing screening, is 151 * 10 with making quantity after the conventional pharmaceutical technology adding necessary medicine excipient (as magnesium stearate)
4Individual tablet (every 0.1g) promptly obtains the tablet of medicine of the present invention, and packs 100 every bottle with bottle.
Embodiment 4
Take by weighing Venenum Bufonis 2kg, Squama Manis 120kg, Hirudo 100kg, Plumbum preparatium 35kg, behind crushing screening, pharmaceutical technology is made powder routinely, and the blended rubber capsule carries out fractional pack, dresses up Caplet 257 * 10 altogether
4Grain (each dress 0.1g powder), and with bottle packing, promptly obtains the capsulation dosage form of medicine of the present invention by 100 every bottle.
Embodiment 5
Take by weighing Venenum Bufonis 1.5kg, Squama Manis 100kg, Hirudo 80kg, Plumbum preparatium 30kg pulverizes, sieves, mixes, and makes powder with conventional pharmaceutical technology and be loaded on vial, and is furnished with the little spoon that metering 0.1g uses in Packaging Bottle, and every bottled 10g adorns 211.5 * 10
3Bottle promptly obtains the powder of medicine of the present invention.
Claims (5)
1, the vasculitic pharmaceutical composition of a kind of treatment is characterized in that its composition is: Venenum Bufonis 0.5-2.5 part, Squama Manis 50-170 part, Hirudo 30-120 part, Plumbum preparatium 10-50 part.
2, pharmaceutical composition according to claim 1 is characterized in that its composition is: Venenum Bufonis 1-2 part, Squama Manis 80-120 part, Hirudo 50-100 part, Plumbum preparatium 20-35 part.
3, pharmaceutical composition according to claim 1 is characterized in that its composition is: 1.5 parts of Venenum Bufoniss, 100 parts of Squama Maniss, 80 parts of Hirudos, 30 parts of Plumbum preparatiums.
4, according to claim 1 or 2 or 3 described pharmaceutical compositions, the dosage form that it is characterized in that this medicine is any pharmaceutical dosage forms commonly used such as pill, powder, tablet, sugar coated tablet, sublimed preparation, capsule.
5, pharmaceutical composition according to claim 4 is characterized in that this medicine also contains medicine excipient commonly used.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98110202A CN1092519C (en) | 1998-05-08 | 1998-05-08 | Chinese medicine for argiitis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98110202A CN1092519C (en) | 1998-05-08 | 1998-05-08 | Chinese medicine for argiitis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1235028A CN1235028A (en) | 1999-11-17 |
| CN1092519C true CN1092519C (en) | 2002-10-16 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN98110202A Expired - Fee Related CN1092519C (en) | 1998-05-08 | 1998-05-08 | Chinese medicine for argiitis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1092519C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106265758A (en) * | 2015-05-13 | 2017-01-04 | 蒋蓉 | One treats vasculitic Chinese patent medicine |
| CN105168648A (en) * | 2015-08-31 | 2015-12-23 | 霍传英 | Orally-taken preparation for treating thromboangiitis obliterans and preparing method thereof |
-
1998
- 1998-05-08 CN CN98110202A patent/CN1092519C/en not_active Expired - Fee Related
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| Publication number | Publication date |
|---|---|
| CN1235028A (en) | 1999-11-17 |
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