CN1235028A - Chinese medicine for argiitis - Google Patents
Chinese medicine for argiitis Download PDFInfo
- Publication number
- CN1235028A CN1235028A CN98110202A CN98110202A CN1235028A CN 1235028 A CN1235028 A CN 1235028A CN 98110202 A CN98110202 A CN 98110202A CN 98110202 A CN98110202 A CN 98110202A CN 1235028 A CN1235028 A CN 1235028A
- Authority
- CN
- China
- Prior art keywords
- medicine
- hirudo
- parts
- pharmaceutical composition
- blood
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Abstract
A Chinese medicine for curing vasculitis is prepared from toad venom (0.5-2.5 portions), pangolin scales (50-170), leech (30-120) and lead oxide (10-50) through conventional process, and features high cure rate.
Description
The present invention relates to medical technical field, relate in particular to the vasculitic Chinese patent medicine of a kind of treatment.
Vasculitis is referred to as one of difficult disease of current medical circle, though this disease is difficult to jeopardize the human life, but cause animally to the patient easily and immeasurable mentally misery, because of there not being real clinical medicine at present, cure rate is extremely low, mostly quantity is saved bigger disease from damage with the medical procedure of taking amputation eventually and is tormented, thereby what bring to the patient is lifelong misery.From present clinical medicine, mainly be to use medicines such as FUFANG DANSHEN PIAN (capsule), Radix Salviae Miltiorrhizae Injection, snake venom antithrombotic enzyme, delay the amputation time by Therapeutic Principle such as blood vessel dilating, antiplatelet cohesions, thereby the performance in therapeutic process be the time long, curative effect is slow, expense is high, relapse rate is high, side effect is big, therefore seek the vasculitic medicine of a kind of treatment, particularly Chinese patent medicine has been pressing for treatment this disease of vasculitis.
The objective of the invention is in order to improve the deficiency of prior art, a kind of to have curative effect fast and provide, and treatment time is short, and expense is low, controls the Chinese patent medicine that is exclusively used in treatment vasculitis disease that the back does not have recurrence.
The objective of the invention is to be achieved by the following technical programs, the vasculitic pharmaceutical composition of a kind of treatment, its composition is:
Venenum Bufonis 0.5-2.5 part, Squama Manis 50-170 part, Hirudo 30-120 part, Plumbum preparatium 10-50 part
The preferable amount proportioning of said components is:
Venenum Bufonis 1-2 part, Squama Manis 80-120 part, Hirudo 50-100 part, Plumbum preparatium 20-35 part
The optimum weight proportioning of pharmaceutical composition of the present invention is:
1.5 parts of Venenum Bufoniss, 100 parts of Squama Maniss, 80 parts of Hirudos, 30 parts of Plumbum preparatiums
Above-mentioned pharmaceutical composition can be equipped with medicine excipient commonly used according to the Chinese medicine preparation technology of routine and be prepared into clinically common formulations, for example any pharmaceutical dosage forms commonly used such as pill, powder, tablet, sugar coated tablet, sublimed preparation, capsule.
Thromboangiitis obliterans is a kind of pernicious thrombus disease, it is the systemic disease that tremulous pulse and vein are got involved simultaneously, and can cause the generation of other disease, theory of Chinese medical science is thought: direct stimulation, impairment caused by overstrain are excessive, can make heart kidney two lose deficiency of heart-blood, the blood vessels operation is not smooth, the loss of kidney water, fire is high partially mutually, and the imbalance of heart kidney takes place, insufficiency of primordial QI, so that the imbalance of the four stages in the course of an epidemic febrile disease fortuneization, can not loose is skillful in blood vessels, and gradually forms deficiency of both QI and blood, adding cold again endures cold, the cold-evil is dissolved in meridians, and makes coagulation of QI-blood, and yang-energy can not be assigned and fall ill.
The effect of medicine of the present invention is: Venenum Bufonis is warm in nature, and the sweet in the mouth suffering is poisonous, has removing toxic substances and promoting subsidence of swelling, and pain relieving is had one's ideas straightened out, and the effect of topical anesthesia cures mainly viral furuncle, diseases such as laryngopharynx swelling and pain, and external application or take medicine orally all can; The Squama Manis cold nature, salty in the mouth has eliminating stasis and resolving masses, and the eliminating carbuncle evacuation of pus is to draw prescribe medicine simply, penetrates meridians, through sick institute; Hirudo property is flat, the salty in the mouth hardship, and slightly poisonous, it is strong to have removing blood stasis power, and dissipating blood stasis to promote menstruationg cures mainly the blood stasis amenorrhea, lump in the abdomen, diseases such as blood-retention are liked anthropophagy's blood most and property is slow because of Hirudo, and slow then hemopoietic is not hindered, and is apt to borrow its power, to attack its stasis of accumulating in the course of time into then hard long-pending easily broken; The Plumbum preparatium is cold in nature, and is poisonous, has detoxifcation, blood stasis dispelling, the effect of granulation promoting.The overall efficacy of pharmaceutical composition of the present invention is: strengthening heart and boosting pressure, vigorous blood circulation, the formation of anticoagulation, thrombosis can blood vessel dilating, blood fat reducing, blood viscosity lowering, effect with convergence, sterilization, detumescence, granulation promoting has inhibitory action to Jia Xingrongxuexinglianqiujun, staphylococcus aureus, and is inhibited to platelet aggregation, can make it to leukocytic minimizing, can improve cellular immunization and humoral immune function.Show according in vitro tests: this medicine can make the setting time of fibrin stock solution prolong, and effect of antithrombase sample and the effect of urokinase sample are arranged, and makes the activation of fibrin solution.
The test example
(1) animal toxicity test
Venenum Bufonis, Hirudo, Plumbum preparatium are all poisonous medicine in the present invention's prescription, and single uses people's death by poisoning is died, but the synthetic toxicity that can make of four Chinese medicine active ingredient reduces in this programme, and the cumulative action of lead ion reduces.The high clear stricture of vagina comrade chief editor who publishes according to the Xueyuan Press " put down in writing in the clinical handbook of practical toxic herb: Venenum Bufonis to the LD50 (mg/kg) of white mice is: intravenous injection 41.0, subcutaneous injection 96.60, lumbar injection 36.24.Hirudo is to female white mice subcutaneous injection Hirudo decoct, and LD50 is 15.24g/kg, toxic dose 15-30g for oral administration.The Plumbum preparatium is 16.70g/kg to mouse mainline LD50, and the LD50 of rat abdominal cavity administration is 220mg/kg.Animal toxicity test is:
1, acute toxicity test
(1) oral medication:
1. getting medicine 2g of the present invention adds water and grinds and to make full dose become the homogenate (concentration is 50mg/ml) of 40ml standby.
2. get 20 of white mice (each 10 of male and female), every white mice gives the equal serosity 0.02ml/g of sample according to the weight and irritates stomach (being equivalent to 1000mg/kg), observed 10 days, the all healthy existence of white mice, there is not any toxicity, through anatomic observation hemogram, liver function, each organs and tissues morphology finding and matched group be zero difference relatively.This product to the oral dosis tolerata of white mice more than 1000mg/kg.
3. get 20 of white mice (each 10 of male and female), every white mice according to the weight respectively grouping (10 every group) give the equal serosity 0.03ml/g of sample and 0.04ml/g irritates stomach (being equivalent to 1500mg/kg, 2000mg/kg respectively), observed 10 days, irritate all healthy existence of white mice of stomach 0.03ml/g group, no toxicity, through anatomic observation hemogram, liver function, each organs and tissues morphology finding and matched group be zero difference relatively.The white mice of irritating stomach 0.04ml/g group showed the dysphoria that has in various degree in 10 days, stupor, wherein dead 2, account for 20%, unusual through the anatomic observation routine blood test, lead content in urine is slightly high, and liver function is normal, other each organs and tissues no abnormality seen is found other pneumorrhagia in 2 white mice dissections to death.This shows medicine of the present invention to the oral maximum tolerated dose of white mice at 1500mg/kg, be 2000 to the LD50 (mg/kg) of mice.
2 accumulation toxicity tests
(1) mouth medication:
1. getting medicine 1g of the present invention adds water and grinds and to make full dose become the homogenate (concentration is 25mg/ml) of 40ml standby.
2. get 40 of white mice (each 20 of male and female), every white mice gives the equal serosity 0.02ml/g of sample according to the weight and irritates stomach (being equivalent to 500mg/kg) once a day, observed three months, the all healthy existence of white mice, there is not any toxicity, through anatomic observation hemogram, liver function, each organs and tissues morphology finding and matched group be zero difference relatively.Substantially do not have in the body and accumulate.
Show through toxicity test, this medicine is at 1500mg/kg to the maximum tolerated dose of mice, to the LD50 of mice more than 2000mg/kg, the accumulation toxicity test of mice is shown that the oral dose of 500mg/kg does not have to be accumulated, being higher than clinical program adult consumption is 400mg, child's consumption is 150mg, and child below three years old does not declare and takes, and this medicine is safe to the patient.
The clinical practice of medicine of the present invention:
Medicine of the present invention carries out clinical practice in 6 tame hospitals to vasculitis disease patient, receives altogether treatment patient 356 people, the elder of sick time 42 years, the shortest has 6 months, what treatment time was the longest is 60 days, and the shortest is 20 days, wherein Quan Yu 326 people, account for 91.6%, 25 people of produce effects account for 7%, 5 invalid people, account for 1.4%, total effective rate reaches 98.6%.Through to the following up a case by regular visits to of patient after curing, patient's complete recovery of health, work identical with the normal person do not found because of taking any untoward reaction that this medicine produces during the treatment.Now take passages typical case history as follows:
1, open * *, man, 76 years old, the Mouping District people of Yantai City, Shandong Province, first visit on May 28 in 1993, patient's self-induction paroxysmal pain had 8 years, and the ant sense is obvious, ulcus cruris, night severe pain unbearably, life is rough to take care of oneself, and repeatedly arrives hospital therapy, effect is always not obvious.Be the biped vasculitis after diagnosing, through taking medicine of the present invention (each 400mg, every day three times), pain disappears after 5 days, recovery from illness in 20 days.So far follow up a case by regular visits to, do not have any recurrence and untoward reaction, still can engage in physical work.
2, grandson * *, man, 36 years old, Shandong Province Laiyang City people.The first visit on the 16th of patient's nineteen ninety-five JIUYUE, readme had two red lines in the left leg inboard before 3 years, and swelling pain disappears through the hospital treatment red line.After this left foot thumb begins pain, after this uninterruptedly takes relevant medicine 3 years, and symptom fails to alleviate all the time, the pain increased, the necrosis of left foot big toe, and toenail comes off, other toenail yellowing, thickening is not grown, the left leg atrophy, look YANG pulse, the Taixi arteries and veins disappears, yellowish fur, and complexion is sallow, lackluster, be diagnosed as three stage angiitis, through taking the 3rd day pain relief of medicine of the present invention (each 400mg, every day three times), pain almost disappears after 10 days, pulse recovers gradually, treats that sequestrum comes off automatically after 20 days, recovery from illness in 55 days.Follow up a case by regular visits to so far patient body and do not see any untoward reaction in order, and with making us the same physical work of engaging in.
3, woods * *, the man, 66 years old, people from Haiyang City, Shandong Province, first visit on June 12 in 1996, patient's readme is cut sufficient heel by colter when farming operation in 1972, secondary infection is after hospitalize recovery from illness; The next year recurrence, state of an illness aggravation, left leg is arrived knee joint by amputation.The modern state of an illness increases the weight of, lower limb pain unbearably, the yellow carbuncle sore thickening blackening of amputation site and hardening, the serious atrophy of right lower limb, the skin dimness, blackout and nonelastic is looked a cun GUAN-pulse weak pulse stringy and thready pulse, this patient's lethargy, One's face was like wax, deep red tongue.Through taking medicine of the present invention pain disappearance after (each 400mg, every day three times) 10 days, two limb colors were recovered gradually in 30 days, and muscle begins flexible, recovery from illness after taking medicine 60 days, and life can take care of oneself.Follow up a case by regular visits to so far, patient body is normal, and untoward reaction and not easypro sense are not arranged.
Describe a kind of specific embodiments for the treatment of vasculitic Chinese patent medicine of the present invention below in detail.
Embodiment 1
Take by weighing Venenum Bufonis 0.5kg, Squama Manis 50kg, Hirudo 30kg, Plumbum preparatium 10kg makes sugar coated tablet 90.5 * 10 with conventional pharmaceutical technology after pulverizing, sieving
4Sheet (every 0.1g) promptly obtains the sugar coated tablet of medicine of the present invention, and packs with little glass medicine bottle, every bottled 100.
Embodiment 2
Take by weighing Venenum Bufonis 2.5kg, Squama Manis 170kg, Hirudo 120kg, Plumbum preparatium 50kg adds 3 kilograms of Mel again as the medicine excipient after pulverizing, sieving, and to make quantity be 172.75 * 10 by producing the conventional pharmaceutical technology of pill or sublimed preparation
4Individual pill (every ball 0.2g) or to make quantity be 345.5 * 10
4Individual medicine pellet (every red 0.1g) promptly obtains pill, the sublimed preparation of medicine of the present invention, and packs with vial.
Embodiment 3
Take by weighing Venenum Bufonis 1kg, Squama Manis 80kg, Hirudo 50kg, Plumbum preparatium 20kg through crushing screening, is 151 * 10 with making quantity after the conventional pharmaceutical technology adding necessary medicine excipient (as magnesium stearate)
4Individual tablet (every 0.1g) promptly obtains the tablet of medicine of the present invention, and packs 100 every bottle with bottle.
Embodiment 4
Take by weighing Venenum Bufonis 2kg, Squama Manis 120kg, Hirudo 100kg, Plumbum preparatium 35kg, behind crushing screening, pharmaceutical technology is made powder routinely, and the blended rubber capsule carries out fractional pack, dresses up Caplet 257 * 10 altogether
4Grain (each dress 0.1g powder), and with bottle packing, promptly obtains the capsulation dosage form of medicine of the present invention by 100 every bottle.
Embodiment 5
Take by weighing Venenum Bufonis 1.5kg, Squama Manis 100kg, Hirudo 80kg, Plumbum preparatium 30kg pulverizes, sieves, mixes, and makes powder with conventional pharmaceutical technology and be loaded on vial, and is furnished with the little spoon that metering 0.1g uses in Packaging Bottle, and every bottled 10g adorns 211.5 * 10
3Bottle promptly obtains the powder of medicine of the present invention.
Claims (5)
1, the vasculitic pharmaceutical composition of a kind of treatment is characterized in that its composition is: Venenum Bufonis 0.5-2.5 part, Squama Manis 50-170 part, Hirudo 30-120 part, Plumbum preparatium 10-50 part.
2, pharmaceutical composition according to claim 1 is characterized in that its composition is: Venenum Bufonis 1-2 part, Squama Manis 80-120 part, Hirudo 50-100 part, Plumbum preparatium 20-35 part.
3, pharmaceutical composition according to claim 1 is characterized in that its composition is: 1.5 parts of Venenum Bufoniss, 100 parts of Squama Maniss, 80 parts of Hirudos, 30 parts of Plumbum preparatiums.
4, according to claim 1 or 2 or 3 described pharmaceutical compositions, the dosage form that it is characterized in that this medicine is any pharmaceutical dosage forms commonly used such as pill, powder, tablet, sugar coated tablet, sublimed preparation, capsule.
5, pharmaceutical composition according to claim 4 is characterized in that this medicine also contains medicine excipient commonly used.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98110202A CN1092519C (en) | 1998-05-08 | 1998-05-08 | Chinese medicine for argiitis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98110202A CN1092519C (en) | 1998-05-08 | 1998-05-08 | Chinese medicine for argiitis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1235028A true CN1235028A (en) | 1999-11-17 |
| CN1092519C CN1092519C (en) | 2002-10-16 |
Family
ID=5220274
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN98110202A Expired - Fee Related CN1092519C (en) | 1998-05-08 | 1998-05-08 | Chinese medicine for argiitis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1092519C (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105168648A (en) * | 2015-08-31 | 2015-12-23 | 霍传英 | Orally-taken preparation for treating thromboangiitis obliterans and preparing method thereof |
| CN106265758A (en) * | 2015-05-13 | 2017-01-04 | 蒋蓉 | One treats vasculitic Chinese patent medicine |
-
1998
- 1998-05-08 CN CN98110202A patent/CN1092519C/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106265758A (en) * | 2015-05-13 | 2017-01-04 | 蒋蓉 | One treats vasculitic Chinese patent medicine |
| CN105168648A (en) * | 2015-08-31 | 2015-12-23 | 霍传英 | Orally-taken preparation for treating thromboangiitis obliterans and preparing method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1092519C (en) | 2002-10-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US11571452B2 (en) | Method of treating a skin wound with a liquid-state topical pharmaceutical composition | |
| CN101703651A (en) | Medicament for treating diabetic gangrene | |
| CN1092519C (en) | Chinese medicine for argiitis | |
| CN111265599A (en) | Application of lycopene and grape seed composition in preparation of medicine for treating arthritis | |
| CN101590169B (en) | Traditional Chinese medicine combination for treating gout and preparation method thereof | |
| CN105456498A (en) | Traditional Chinese medicinal preparation for treating diabetic foot ulcer | |
| CN1120721C (en) | Exterior-applied ointment for treating piles | |
| CN1068785C (en) | Chinese patent medicine for external application for curing diseases of scald, burn and dermal ulcer | |
| CN101259200B (en) | Orally-administered and externally-applied specific medicine for treating bone injury disease, protrusion of lumbar intervertebral discs and wrick | |
| CN106265758A (en) | One treats vasculitic Chinese patent medicine | |
| CN104547591A (en) | Pharmaceutical composition for treating acute ankle sprain | |
| CN116036168B (en) | Traditional Chinese medicine composition for treating phlebitis and application thereof | |
| CN114340650A (en) | Combined medicine for treating osteoarthritis | |
| JP2941160B2 (en) | Relief agent for shingles pain | |
| CN108686102A (en) | A kind of Chinese medicine composition for treating gout | |
| CN107875200A (en) | A kind of Chinese medicine composition of effectively treatment tinea pedis | |
| CN114246905A (en) | Application of traditional Chinese medicine composition in preparation of medicine for preventing and treating coronary heart disease and restenosis after PCI (percutaneous coronary intervention) operation | |
| CN105832743A (en) | Tablet for preventing complications after renal injury | |
| CN1228059C (en) | Bone setting ointment | |
| CN1615969A (en) | Chinese medicine preparation pus drawing out plaster for treating pasteur cystic, furuncle, furunculosis and carbuncle | |
| CN110721248A (en) | Medicine composition for treating venomous snake bite | |
| CN104740029B (en) | A kind of pharmaceutical composition for the treatment of gout | |
| CN1313110C (en) | Oteoproliferation treating plaster and preparation method thereof | |
| CN113143986A (en) | Medicine for treating pulmonary tuberculosis | |
| CN114129622A (en) | Composition for treating burns and scalds, preparation method and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |