CN109223885A - A kind of antifatigue liquid medicine - Google Patents
A kind of antifatigue liquid medicine Download PDFInfo
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- CN109223885A CN109223885A CN201811356308.4A CN201811356308A CN109223885A CN 109223885 A CN109223885 A CN 109223885A CN 201811356308 A CN201811356308 A CN 201811356308A CN 109223885 A CN109223885 A CN 109223885A
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/486—Millettia
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The present invention relates to a kind of antifatigue liquid medicine, which is made of edible rice wine and effective component；Effective component in liquid medicine described in every liter is made of the bulk pharmaceutical chemicals of following weight proportion: sweet 45~55g of Shen, 8~12g of beautiful millettia root, 8~12g of radix fici simplicissimae, 1.5~2.5g of dried orange peel, 1.5~2.5g of Radix Glycyrrhizae.Not only flavour of a drug are few for liquid medicine of the present invention, but also antifatigue significant effect.
Description
Invention field
The medicinal preparation for the not determining structure containing the fruit from myrtle hill gooseberry that the present invention relates to a kind of,
More particularly to liquid medicine, which has anti-fatigue effect.
Background technique
Fatigue is not regarded as to will lead to serious physical disease, therefore as physical phenomena quotidian in daily life
Usually ignored by people.But in ancient Chinese medical literature, but there is the discussion largely about fatigue, Chinese medicine thinks, tired
The appearance of labor phenomenon, the imbalance with the five internal organs have close relationship, if weakness of limbs is mostly related with taste, waist soreness mostly with kidney
Related, short wind is mostly related with lungs, and insobriety is mostly related with heart, and endurance is not mostly related with liver.Over time,
It is mainly shown as that attention is laxed, the decline of failure of memory, training achievement, off feed, weight loss, is stranded in human body behavior
Tired and have a sleepless night, feel dizzy, long can then cause neurasthenia, resting heart rate to be accelerated, or even Heart enlargement, pathology occur miscellaneous
Sound etc..Therefore, seek a kind of to play tcm characteristic popular antifatigue method is desirability again.Chinese medicine is needed because of people
Application, bitter are difficult to entrance, and decoction needs to decoct again, complicated for operation, time-consuming and laborious.And liquid medicine is as civil a kind of heavy in China
Health care product is wanted, there is medicinal well and physical therapy value.
Summary of the invention
Technical problem to be solved by the invention is to provide a kind of antifatigue liquid medicine, and not only flavour of a drug are few for the liquid medicine, but also
Antifatigue significant effect.
Technical proposal that the invention solves the above-mentioned problems is as follows:
A kind of antifatigue liquid medicine, the liquid medicine are made of edible rice wine and effective component；Having in liquid medicine described in every liter
Effect ingredient is made of the bulk pharmaceutical chemicals of following weight proportion: sweet 45~55g of Shen, 8~12g of beautiful millettia root, radix fici simplicissimae 8~12g are old
1.5~2.5g of skin, 1.5~2.5g of Radix Glycyrrhizae.
Above scheme of the present invention, wherein the optimum proportioning of the bulk pharmaceutical chemicals is: sweet Shen 50g, beautiful millettia root 10g, the five fingers hair
Peach 10g, dried orange peel 2g, Radix Glycyrrhizae 2g.
In above scheme, sweet Shen is the sweet Shen fruit of fresh mature.
In above scheme, the alcoholic strength of the edible rice wine be 30~50 (volumetric concentration of i.e. 20 ° lower alcohol is 30~
50%).
Liquid medicine of the present invention is prepared by following methods:
(1) bulk pharmaceutical chemicals are taken, the edible rice wine that 8~10 times of amounts are added impregnates 15~60 days, filters waste, obtains medicine
Wine stoste；
(2) suitable trehalose is added into obtained liquid medicine stoste, stirs evenly, edible rice wine constant volume is then added
To 1000ml to get the liquid medicine.
Impregnated in (1) in order to improve the clarity of the liquid medicine, the step of the above method with alcoholic strength of edible rice wine with
Constant volume is identical edible rice wine (that is, production firm is identical, kind is identical, alcoholic strength is equal) with edible rice wine in step (2).
In the prescription of liquid medicine of the present invention, sweet Shen is sweet puckery, flat, returns liver and spleen lung channel, boosting qi and nourishing yin, puckery intestines controlling nocturnal emission with astringent drugs,
Nourishing blood and hemoslasis is monarch drug in a prescription；Beautiful millettia root is sweet flat, and return lung kidney channel, qi-restoratives moistening lung, strengthening tendons are active, and radix fici simplicissimae is mild-natured, sweet in flavor, pungent, has
Strengthening the spleen and tonifying the lung, dampness removing relaxing muscles and tendons function, two medicines are ministerial drug altogether, help the vital essence of sweet Shen tonifying spleen lung, kidney-nourishing through gas essence；Assistant is with old
Skin, bitter and warm, regulating qi-flowing for strengthening spleen is eliminating dampness and eliminating phlegm, prevents that all medicine tastes are greasy too；Radix Glycyrrhizae sweet in flavor and neutral in nature is nontoxic, coordinating the drug actions of a prescription, to make medicine；
All medicines share, can be with supplementing qi and nourishing yin, nourishing liver and kidney, strengthening the spleen and reducing phlegm.
In order to be best understood from the present invention, the antifatigue and antioxidant effect of liquid medicine of the present invention is verified below.
1. anti-fatigue effect animal experiment method
1.1. animal packet
SPF grades KM mouse 88, weight 16-18g, male is randomly divided into two big groups, wherein first group (is only used for measuring
Mouse power exhausts the time of swimming) it is divided into model group (Mod.), positive group (Spi.), experimental group 1, experimental group 2 and experimental group 3, totally 5
Group, every group 8；Second group is divided into blank group (for collecting mouse weight data, antifatigue and anti-oxidant data)
(Con.), model group, positive group, experimental group 1,2 and 3, totally 6 group, every group 8.Adaptive feeding is tested after a week.
Groups of animals free water and feed during stomach-filling is raised.
1.2. animal medication
Blank group and model group give physiological saline, and positive group is given 800mg/kg spirulina, experimental group 1,2 and of experimental group
Experimental group 3 gives the liquid medicine of following embodiments 1,2 and 3 respectively.Every group of mouse is used gastric perfusion needle stomach-filling 1 time daily, dosage be for
0.1mL/10g (mouse weight), continuous gavage 20 days.Simultaneously record second group in each mouse for the first time with body when last stomach-filling
Weight.
1.3. swimming with a load attached to the body is tested
After first group of mouse last dose 30min, swimming with a load attached to the body experiment is carried out, it is negative with mouse weight in mouse tail root
5% galvanized wire, being put into water temperature is depth of water 40cm in (25.0 ± 0.5) DEG C swimming trunk, is exhausted since swimming to power with stopwatch record
The time of (10s cannot still emerge after mouse sinking) is as mouse swimming time.
1.4. biochemical indicator detects
After second group of mouse last dose 30min, swimming with a load attached to the body experiment is carried out.Blank group is not swum, other five groups upper
It states under 1.3. swimming condition, after the 30min that swims, takes out dry immediately, carry out eye socket and take blood, at 4 DEG C, with 3000 turns per minute
Centrifugation 15 minutes takes supernatant serum, and -80 DEG C save in case measurement blood glucose (Glu), urea nitrogen (Bun), lactic acid (LD), lactic acid
The content of dehydrogenase (LDH) and creatine kinase (CK)；Mouse vertebra dislocation after taking blood is lethal, takes out hind leg muscle and liver immediately
Dirty, a part is for measuring malonaldehyde (MDA), superoxide dismutase (SOD), catalase (CAT) and gst enzyme
(GSH), remaining saves the content in case detection hepatic glycogen and muscle glycogen in -80 DEG C.
1.5. statistical analysis
Experiment each group of data is indicated with mean ± standard deviation (mean ± SD), using 7 software system of Graphpad Prism
Figure, carries out statistical analysis with SPSS21.0 software, and using one-way analysis of variance method, two groups of P < 0.05 and the display of P < 0.01 are poor
It is different statistically significant.
2. anti-fatigue effect experimental result
2.1. influence of the liquid medicine of the present invention to mouse weight
After administration 20 days, each group mouse is active, and the state of mind is good, and fur is smooth, has no any adverse reaction.To second group
The influence of mouse weight, as a result see the table below 1.Each medication group mouse is from weight differences when testing start and ending, with blank group phase
Than, it is not statistically significant (P > 0.05), show that liquid medicine of the present invention has no significant effect mouse weight growth, explanation does not have
Reach antifatigue effect by way of putting on weight.
Influence of the liquid medicine of the present invention of table 1 to mouse weight
2.2. influence of the liquid medicine of the present invention to mouse swimming time
Walking weight load is the degree for reflecting sports fatigue, in this experiment using first group of KM mouse as research object,
Loaned swimming test is carried out after continuous gavage liquid medicine of the present invention 20 days, test result is shown in Fig. 1.The results show that and model
Group compares, and after taking positive drug spirulina and liquid medicine of the present invention, can extend mouse swimming time (P < 0.01),
Wherein 1 effect of liquid medicine experimental group of the present invention is best.Show that liquid medicine of the present invention is remarkably improved the exercise tolerance of mouse,
With anti-fatigue effect.
2.3. influence of the liquid medicine of the present invention to mouse blood sugar after swimming (Glu)
Influence of the liquid medicine of the present invention to Glu in mice serum is as shown in Fig. 2, compared to the blank group, each group after swimming
Different degrees of decline is presented in mouse.Wherein compared to the blank group, difference has conspicuousness (P < 0.01) to model group, display
Swimming reduces the blood-sugar content of mouse.And compared with model group, positive group spirulina conspicuousness improves in swimming Mice Body
Glu, while Glu content is also apparently higher than model group in liquid medicine dosage group of the present invention, with otherness (P < 0.01),
Illustrate that liquid medicine of the present invention can improve the consumption for slowing down the blood glucose during swimming, increases the adaptability to body.
2.4. liquid medicine of the present invention is to urinary nitrogen in serum (Bun), lactic acid (LD), lactic dehydrogenase (LDH) and creatine
The influence of kinases (CK)
As shown in figure 3, compared with naive mice, after swimming in model group mice serum Bun, LD, LDH and CK content
Significantly increase (P < 0.01).Compared with model group, the positive controls for feeding spirulina can significantly reduce above 4 fingers
Target content (P < 0.01), and liquid medicine different experiments group of the present invention can also reduce their content, with otherness (P <
0.05), especially experimental group 1 is optimal.Illustrate that liquid medicine of the present invention can be reduced the urea nitrogen in motion process, lactic acid, lactic acid
The content of dehydrogenase and creatine kinase increases the adaptability to body.
2.5. liquid medicine of the present invention is to antioxidant effect in swimming Mice Body
In order to evaluate liquid medicine of the present invention to the antioxidant effect of mouse, liver SOD, CAT, GSH vigor and MDA are contained
Amount is determined, and measurement result is shown in Fig. 4, and model group mouse is after 30min swims, and compared with naive mice, finds MDA's
Content apparent increase (P < 0.01), and the content of SOD, CAT and GSH significantly reduce (P < 0.01).But by with spirulina and
Carried out after liquid medicine of the present invention is oral after swimming test with model group after comparison, it was found that, spirulina positive group can be substantially reduced
The content (P < 0.01) of MDA and the content (P < 0.01) for improving SOD, CAT and GSH, reduce after liquid medicine stomach-filling of the present invention
The content of MDA in mouse liver, while can significantly improve the content (P < 0.05) of SOD, CAT and GSH
2.6. influence of the liquid medicine of the present invention to Glycogen concentration
Liver and muscle are the main portions of human body energy storage, and glycogen is then direct energy substance.Experimental data is aobvious
Show (Fig. 5), compared to the blank group, the hepatic glycogen and muscle glycogen content of mouse significantly reduce (P < 0.01) after swimming.Compared to model
Group, spirulina positive group can significantly improve mouse hepatic glycogen and muscle glycogen levels (P < 0.01), and liquid medicine of the present invention is respectively tested
The hepatic glycogen and muscle glycogen of group mouse dramatically increase (P < 0.05), and are positively correlated with dosage.Show medicine of the present invention
Wine can reduce the consumption of muscle glycogen and hepatic glycogen.
Detailed description of the invention
Fig. 1 is the bar chart of influence (n=8) of the liquid medicine of the present invention to the mice burden swimming time, in figure, * * be with
Mod. group compares P < 0.01.
Fig. 2 is the result figure of influence (n=8) of the liquid medicine of the present invention to mouse's blood sugar content, and in figure, ## is and Con.
Group compares P < 0.01, and * * is P < 0.01 compared with Mod. group.
Fig. 3 is that liquid medicine of the present invention swashs mouse urinary nitrogen (Bun), lactic acid (LD), lactic dehydrogenase (LDH) and creatine
The result figure of the influence (n=8) of enzyme (CK) content, wherein A figure is the bar chart of mouse Bun content, and B figure is mouse LD content
Bar chart, C figure is the bar chart of mouse LDH content, and D figure is the bar chart of mouse CK content.In figure, ## is and Con. group ratio
It is P < 0.05 compared with Mod. group compared with P < 0.01, *, * * is P < 0.01 compared with Mod. group.
Fig. 4 is the result figure of influence (n=8) of the liquid medicine of the present invention to mouse antioxidant effect, wherein A figure is small
The bar chart of mouse malonaldehyde (MDA) content, B figure are the bar chart of mouse superoxide dismutase (SOD) content, and C figure is mouse
The bar chart of CAT content, D figure are the bar chart of mouse GSH content, and in figure, ## is P < 0.01 compared with Con. group, * be with
Mod. group compares P < 0.05, and * * is P < 0.01 compared with Mod. group.
Fig. 5 is the result figure of influence (n=8) of the liquid medicine of the present invention to mouse hepatic glycogen and muscle glycogen content, wherein
A figure is the bar chart of mouse hepatic glycogen content, and B figure is the bar chart of mouse muscle glycogen content, and in figure, ## is compared with Con. group
P < 0.01, * are P < 0.05 compared with Mod. group, and * * is P < 0.01 compared with Mod. group.
Con. represents blank group, Mod. representative model group in above-mentioned Fig. 1-5, and Spi. represents positive group, and GRZ1,2 and 3 are distinguished
Represent experimental group 1,2 and 3.
Specific embodiment
Embodiment 1
1, prescription: sweet Shen 50g, beautiful millettia root 10g, radix fici simplicissimae 10g, dried orange peel 2g, Radix Glycyrrhizae 2g.
2, preparation method:
(1) sweet Shen of bulk pharmaceutical chemicals medicine, beautiful millettia root, radix fici simplicissimae, dried orange peel and Radix Glycyrrhizae are taken, 9 times of amount Guangdong Chenghai breweries are added
40 degree of edible rice wine of limited liability company's production impregnates 38 days, filters waste, obtains liquid medicine stoste；
(2) trehalose 50g is added into obtained liquid medicine stoste, stirs evenly, Guangdong Chenghai brewery stock is then added
40 degree of edible rice wine of part Co., Ltd production is settled to 1000ml to get the liquid medicine.
Embodiment 2
1, prescription: sweet Shen 54g, beautiful millettia root 8g, radix fici simplicissimae 8g, dried orange peel 1.5g, Radix Glycyrrhizae 2.5g.
2, preparation method:
(1) sweet Shen of bulk pharmaceutical chemicals medicine, beautiful millettia root, radix fici simplicissimae, dried orange peel and Radix Glycyrrhizae are taken, 12 Bei Liang Shunde breweries are added
30 degree of edible rice wine of Co., Ltd's production impregnates 12 days, filters waste, obtains liquid medicine stoste；
(2) trehalose 50g is added into obtained liquid medicine stoste, stirs evenly, Shunde brewery, which is then added, to be had
30 degree of edible rice wine of limit company production is settled to 1000ml to get the liquid medicine.
Embodiment 3
1, prescription: sweet Shen 46g, beautiful millettia root 12g, radix fici simplicissimae 12g, dried orange peel 2.5g, Radix Glycyrrhizae 1.5g.
2, preparation method:
(1) sweet Shen of bulk pharmaceutical chemicals medicine, beautiful millettia root, radix fici simplicissimae, dried orange peel and Radix Glycyrrhizae are taken, 8 Guangdong Province Bei Liang Jiujiang wine are added
50 degree of edible rice wine of Co., Ltd., Factory's production impregnates 60 days, filters waste, obtains liquid medicine stoste；
(2) trehalose 50g is added into obtained liquid medicine stoste, stirs evenly, Guangdong Province Jiujiang brewery is then added
50 degree of edible rice wine of Co., Ltd's production is settled to 1000ml to get the liquid medicine.
Claims (4)
1. a kind of antifatigue liquid medicine, which is made of edible rice wine and effective component；It is effective in liquid medicine described in every liter
Ingredient is made of the bulk pharmaceutical chemicals of following weight proportion: sweet 45~55g of Shen, 8~12g of beautiful millettia root, 8~12g of radix fici simplicissimae, dried orange peel
1.5~2.5g, 1.5~2.5g of Radix Glycyrrhizae.
2. the antifatigue liquid medicine of one kind according to claim 1, which is characterized in that in liquid medicine described in every liter it is effective at
Divide and be made of the bulk pharmaceutical chemicals of following weight proportion: sweet Shen 50g, beautiful millettia root 10g, radix fici simplicissimae 10g, dried orange peel 2g, Radix Glycyrrhizae 2g.
3. the antifatigue liquid medicine of one kind according to claim 1 or 2, which is characterized in that the effective component is by following
Method is prepared:
(1) bulk pharmaceutical chemicals are taken, the edible rice wine that 8~10 times of amounts are added impregnates 15~60 days, filters waste, obtains liquid medicine original
Liquid；
(2) suitable trehalose is added into obtained liquid medicine stoste, stirs evenly, edible rice wine is then added and is settled to
1000ml is to get the liquid medicine.
4. the antifatigue liquid medicine of one kind according to claim 3, which is characterized in that impregnated in (1) the step of the method
Using edible rice wine with constant volume in the alcoholic strength of edible rice wine and step (2) is identical edible rice wine.
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| CN201811356308.4A CN109223885B (en) | 2018-11-15 | 2018-11-15 | Anti-fatigue medicinal liquor |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107737244A (en) * | 2017-12-13 | 2018-02-27 | 海南双健生物科技有限公司 | A kind of medicinal liquor containing beautiful millettia root and preparation method thereof |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107737244A (en) * | 2017-12-13 | 2018-02-27 | 海南双健生物科技有限公司 | A kind of medicinal liquor containing beautiful millettia root and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 张敬礼等: "《寿世补元》", 31 January 2002 * |
| 王茂媛等: "牛大力速溶茶的研制加工", 《热带农业科学》 * |
| 赖来展等: "《黑色食品与健康长寿》", 31 October 2014, 金盾出版社 * |
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