CN109219463B - 用于将颗粒输送到上呼吸道中的装置和方法 - Google Patents
用于将颗粒输送到上呼吸道中的装置和方法 Download PDFInfo
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- CN109219463B CN109219463B CN201780032117.XA CN201780032117A CN109219463B CN 109219463 B CN109219463 B CN 109219463B CN 201780032117 A CN201780032117 A CN 201780032117A CN 109219463 B CN109219463 B CN 109219463B
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662312878P | 2016-03-24 | 2016-03-24 | |
| US62/312,878 | 2016-03-24 | ||
| PCT/CA2017/050027 WO2017161442A1 (en) | 2016-03-24 | 2017-01-11 | Device and method of delivering particles in the upper respiratory tract |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109219463A CN109219463A (zh) | 2019-01-15 |
| CN109219463B true CN109219463B (zh) | 2021-05-11 |
Family
ID=59897024
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201780032117.XA Active CN109219463B (zh) | 2016-03-24 | 2017-01-11 | 用于将颗粒输送到上呼吸道中的装置和方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US11278684B2 (enExample) |
| EP (1) | EP3432954B1 (enExample) |
| JP (1) | JP2019513436A (enExample) |
| CN (1) | CN109219463B (enExample) |
| WO (1) | WO2017161442A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019125304A1 (en) * | 2017-12-18 | 2019-06-27 | National University Of Singapore | Spacer device for an inhaler and method of manufacture thereof |
| US20210008305A1 (en) * | 2018-03-09 | 2021-01-14 | Health Research, Inc. | Induction spacer for inhaler |
| CN111973848B (zh) * | 2020-07-13 | 2022-09-02 | 四川省人民医院 | 一种吸入剂装置 |
| US11172707B1 (en) * | 2020-07-23 | 2021-11-16 | Claude Harper | Smoking assemblies and methods of smoking |
| US20240196972A1 (en) * | 2022-12-14 | 2024-06-20 | R.J. Reynolds Tobacco Company | Aerosol delivery device with deflectable or collapsible housing |
| CN119405953B (zh) * | 2024-12-10 | 2025-09-30 | 中国人民解放军陆军军医大学第一附属医院 | 吸入型药物的给药装置 |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5579760A (en) * | 1992-11-06 | 1996-12-03 | Angiomed Ag | Process and apparatus for producing an aerosol from a pulverulent substance |
| US5906202A (en) * | 1996-11-21 | 1999-05-25 | Aradigm Corporation | Device and method for directing aerosolized mist to a specific area of the respiratory tract |
| EP0957961B1 (de) * | 1995-10-02 | 2002-08-28 | WMC Mediation & Consulting Gmbh | Inhalationshilfsgerät |
| GB2468794A (en) * | 2006-11-28 | 2010-09-22 | Optinose As | Nasal delivery devices |
| CN104436386A (zh) * | 2014-11-14 | 2015-03-25 | 广州医科大学附属第一医院 | 辅助呼吸气雾气体的装置及调节呼吸气雾气体的方法 |
| CN105396206A (zh) * | 2015-11-27 | 2016-03-16 | 江苏鹿得医疗电子股份有限公司 | 带吸气感应间歇送风式医用超声波雾化器 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1586716A (en) | 1925-04-06 | 1926-06-01 | Jr Samuel P Snow | Surgical instrument |
| US2788784A (en) | 1955-08-23 | 1957-04-16 | Herbert M Birch | Means for administering medication orally into the respiratory organs |
| US4534343A (en) | 1984-01-27 | 1985-08-13 | Trutek Research, Inc. | Metered dose inhaler |
| US4790305A (en) | 1986-06-23 | 1988-12-13 | The Johns Hopkins University | Medication delivery system |
| US4796614A (en) * | 1987-02-26 | 1989-01-10 | Trutek Research, Inc. | Collapsible inhalation valve |
| US5042467A (en) | 1990-03-28 | 1991-08-27 | Trudell Medical | Medication inhaler with fitting having a sonic signalling device |
| US5570683A (en) * | 1990-12-05 | 1996-11-05 | The General Hospital Corporation | Methods and devices for treating pulmonary vasoconstriction and asthma |
| US5040527A (en) | 1990-12-18 | 1991-08-20 | Healthscan Products Inc. | Metered dose inhalation unit with slide means |
| US5431154A (en) | 1991-11-29 | 1995-07-11 | Seigel; David | Incentive metered dose inhaler |
| US5320094A (en) * | 1992-01-10 | 1994-06-14 | The Johns Hopkins University | Method of administering insulin |
| US5672581A (en) * | 1993-01-29 | 1997-09-30 | Aradigm Corporation | Method of administration of insulin |
| US5522380A (en) | 1995-01-18 | 1996-06-04 | Dwork; Paul | Metered dose medication adaptor with improved incentive spirometer |
| US5738087A (en) | 1995-09-21 | 1998-04-14 | King; Russell W. | Aerosol medication delivery system |
| US5797392C1 (en) | 1996-01-22 | 2001-01-09 | Direct Haler As | Inhaler |
| US6039042A (en) | 1998-02-23 | 2000-03-21 | Thayer Medical Corporation | Portable chamber for metered dose inhaler dispensers |
| US6026807A (en) * | 1998-02-27 | 2000-02-22 | Diemolding Corporation | Metered dose inhaler cloud chamber |
| NZ521051A (en) * | 2000-02-11 | 2003-07-25 | Profile Respiratory Systems Lt | Drug delivery apparatus |
| US8820316B2 (en) * | 2000-02-11 | 2014-09-02 | Respironics Respiratory Drug Delivery (Uk) Ltd | Drug delivery apparatus |
| US7013896B2 (en) | 2001-05-08 | 2006-03-21 | Trudell Medical International | Mask with inhalation valve |
| US20030168057A1 (en) * | 2001-12-14 | 2003-09-11 | Inhale Therapeutic Systems, Inc. | Electronically controllable aerosol delivery |
| US20030159693A1 (en) * | 2002-02-27 | 2003-08-28 | Richard Melker | Breath-activated, microprocessor controlled system for pulmonary drug delivery |
| US6718969B1 (en) * | 2002-05-28 | 2004-04-13 | Darren Rubin | Medication dosage inhaler system |
| PL1670482T5 (pl) * | 2003-09-16 | 2022-10-03 | Covis Pharma Gmbh | Zastosowanie cyklezonidu w leczeniu chorób układu oddechowego |
| US7900625B2 (en) | 2005-08-26 | 2011-03-08 | North Carolina State University | Inhaler system for targeted maximum drug-aerosol delivery |
| WO2008001132A1 (en) * | 2006-06-27 | 2008-01-03 | Brintech International Limited | Inhaler |
| US20080066739A1 (en) * | 2006-09-20 | 2008-03-20 | Lemahieu Edward | Methods and systems of delivering medication via inhalation |
| US8251876B2 (en) | 2008-04-22 | 2012-08-28 | Hill-Rom Services, Inc. | Breathing exercise apparatus |
| FR2954707B1 (fr) * | 2009-12-28 | 2016-01-08 | Diffusion Tech Francaise Sarl | Dispositif d'administration d'aerosol par voie buccale a visee rhinopharyngee, nasale ou nasosinusienne |
| WO2011162316A1 (ja) | 2010-06-24 | 2011-12-29 | 公立大学法人名古屋市立大学 | 薬剤吸入器及び薬剤供給方法 |
| EP2608829A4 (en) * | 2010-08-23 | 2015-11-18 | Darren Rubin | SYSTEMS AND METHODS FOR AEROSOL SUPPLY WITH AIRFLOW REGULATION |
| US9757528B2 (en) * | 2010-08-23 | 2017-09-12 | Darren Rubin | Nebulizer having different negative pressure threshold settings |
| US8770188B2 (en) | 2011-03-31 | 2014-07-08 | Carefusion 207, Inc. | Metered dose inhaler spacer |
| WO2014046993A1 (en) * | 2012-09-24 | 2014-03-27 | Aerodesigns, Inc. | Flow diverter for a mouthpiece of a particule delivery device |
| WO2015042352A1 (en) * | 2013-09-20 | 2015-03-26 | Virginia Commonwealth University | Delivery of particles using hygroscopic excipients |
| US10245393B2 (en) * | 2014-08-13 | 2019-04-02 | Elwha Llc | Methods, systems, and devices related to a supplemental inhaler |
-
2017
- 2017-01-11 EP EP17769205.0A patent/EP3432954B1/en active Active
- 2017-01-11 WO PCT/CA2017/050027 patent/WO2017161442A1/en not_active Ceased
- 2017-01-11 CN CN201780032117.XA patent/CN109219463B/zh active Active
- 2017-01-11 JP JP2018549233A patent/JP2019513436A/ja active Pending
- 2017-10-31 US US15/798,866 patent/US11278684B2/en active Active
- 2017-10-31 US US15/798,993 patent/US10391268B2/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5579760A (en) * | 1992-11-06 | 1996-12-03 | Angiomed Ag | Process and apparatus for producing an aerosol from a pulverulent substance |
| EP0957961B1 (de) * | 1995-10-02 | 2002-08-28 | WMC Mediation & Consulting Gmbh | Inhalationshilfsgerät |
| US5906202A (en) * | 1996-11-21 | 1999-05-25 | Aradigm Corporation | Device and method for directing aerosolized mist to a specific area of the respiratory tract |
| GB2468794A (en) * | 2006-11-28 | 2010-09-22 | Optinose As | Nasal delivery devices |
| CN104436386A (zh) * | 2014-11-14 | 2015-03-25 | 广州医科大学附属第一医院 | 辅助呼吸气雾气体的装置及调节呼吸气雾气体的方法 |
| CN105396206A (zh) * | 2015-11-27 | 2016-03-16 | 江苏鹿得医疗电子股份有限公司 | 带吸气感应间歇送风式医用超声波雾化器 |
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|---|---|
| US20180050165A1 (en) | 2018-02-22 |
| JP2019513436A (ja) | 2019-05-30 |
| CN109219463A (zh) | 2019-01-15 |
| EP3432954B1 (en) | 2022-04-20 |
| EP3432954A1 (en) | 2019-01-30 |
| US10391268B2 (en) | 2019-08-27 |
| US11278684B2 (en) | 2022-03-22 |
| WO2017161442A1 (en) | 2017-09-28 |
| US20180043112A1 (en) | 2018-02-15 |
| EP3432954A4 (en) | 2020-03-04 |
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