CN109198182A - A kind of Chinese medicine compound prescription additive for animal and fowl fodder - Google Patents
A kind of Chinese medicine compound prescription additive for animal and fowl fodder Download PDFInfo
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- CN109198182A CN109198182A CN201811252694.2A CN201811252694A CN109198182A CN 109198182 A CN109198182 A CN 109198182A CN 201811252694 A CN201811252694 A CN 201811252694A CN 109198182 A CN109198182 A CN 109198182A
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
- A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/68—Plantaginaceae (Plantain Family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
Abstract
The invention discloses a kind of Chinese medicine compound prescription additive formulas for animal and fowl fodder, it is made of the raw material of following weight percentage: red date powder 95~97%, milk thistle extract (silibinin content is 10%) 1~2%, Herba Plantaginis extract 2~3%, the sum of mass percent of above-mentioned raw materials are 100%.Livestock and poultry health care Chinese medicine compound prescription additive prepared by the present invention, it is added in animal and fowl fodder according to 2%, monthly feed 10 days, continuous feeding 3 months, livestock birds health can be promoted to grow, mycotoxin remaining in feed, chemical antimicrobial DP finish and other toxin are reduced to security risk caused by livestock and poultry, improve production performance.
Description
Technical field
The invention belongs to Chinese herbal feed additive technical field, it is related to promoting production performance, liver protection kidney to act on livestock and poultry
A kind of Chinese herbal feed additive, and in particular to Chinese medicine compound prescription additive for animal and fowl fodder.
Background technique
The economic benefit that the safety problem of feed influences livestock and poultry breeding industry also endangers public food safety.As livestock and poultry are intensive
Change the continuous expansion of large-scale cultivation, other toxin in various pathogenic factors such as mycotoxin, antibacterials toxin and feed
It is also increasing to the harm of livestock and poultry.The content of Mycotoxins in Feed is reduced by adding various mold toxin sorbents,
But the various toxin remained in feed still will cause the damage of animal, for example, mould and mycotoxin are to livestock-raising
The harm of industry is huge, can not only reduce the nutritional ingredient of feed, so that it is lost utility value, and mycotoxin can be to animal machine
The digestion of body, reproduction, angiocarpy and multiple systems such as immune damage, and cause animal under the utilization rate and conversion ratio of feed
Drop, daily gain are reduced, and growth performance reduces, and finally cause serious economic loss to aquaculture.In animal and fowl fodder in addition
Chinese herbal medicine additive agent is a traditional technology, and Chinese herbal and crude drugs preparations have significant advantage, medicine in growth promotion, protection liver kidney and removing toxic substances
Object also compares more.For the present invention through Select to use jujube, milk thistle extract and Herba Plantaginis extract prescription and research, truly having can
Promote livestock birds health growth, improve production performance, reduces mycotoxin remaining in feed, chemical antimicrobial DP finish and other poison
Element is to security risk caused by livestock and poultry.
Summary of the invention
It is above-mentioned deposit in the prior art aiming at the problem that and defect, the purpose of the present invention is to provide one kind be used for animal and fowl fodder
Chinese medicine compound prescription additive, which can promote livestock birds health to grow, and improve production performance, reduce in feed
The mycotoxin of remaining, chemical antimicrobial DP finish and other toxin are to security risk caused by livestock and poultry, especially suitable for by each
Growth of animals or poultry caused by kind feed toxin etc. is slow.
Technical solution used by practical foregoing invention purpose is: a kind of Chinese medicine compound prescription additive for animal and fowl fodder,
It is made of the raw material of following weight percentage: red date powder 95~97%, milk thistle extract 1~2%, Herba Plantaginis extract 2~
3%, the sum of mass percent of above-mentioned raw materials is 100%；
Silibinin content is 10% in the milk thistle extract.
A kind of Chinese medicine compound prescription additive optimum proportioning for animal and fowl fodder of the present invention by following weight percentage raw material
It is made: red date powder 96%, milk thistle extract 1.5%, Herba Plantaginis extract 2.5%, the sum of mass percent of above-mentioned raw materials
It is 100%.
It is a still further object of the present invention to provide a kind of Chinese medicine compound prescription additives for animal and fowl fodder to raise in production livestock and poultry
Application in material.
The milk thistle extract and Herba Plantaginis extract in formula are taken, is made according to ratio and the red date powder mixing of formula scattered
Pulvis；The auxiliary material dextrin of appropriate ratio can also be added in loose powder, mix, particle is made in granulator.
The Chinese medicine compound prescription additive of animal and fowl fodder of the present invention is to be showed based on traditional Chinese medical theory referring to modern Chinese herbal medicine
Generationization research achievement is made according to traditional Chinese medicine combination principle.The present invention can prevent and treat Mycotoxins in Feed, chemical antibacterial
Class drug, which is crossed, to security risk caused by livestock and poultry, can be effectively relieved the disease that above-mentioned toxin damages livestock and poultry with other toxin
Shape is eliminated to livestock and poultry liver tissue injury, it is slow to be suitable for the growth of animals or poultry as caused by feed toxin poisoning etc..
Jujube, milk thistle and Herba Plantaginis extract in formula of the invention, jujube is warm-natured to put down sweet in flavor, enters taste warp, nontoxic,
Energy tonifying middle-Jiao and Qi, nourishing stomach and spleen, blood-nourishing is strong refreshing, and moistening herat and lung adjusts battalion to defend, born fluid, happy color, solves poisoning of drug, the function of hundred medicines of reconciliation
Effect, jujube have " spleen is supported in peace " effect, are the fruits of spleen.Studies have shown that not only containing nutritional ingredient extremely abundant in jujube, also
There is various bioactive components, including red jujube polysaccharide, phenols, saponin(e, cyclic nucleotide, alkaloid, essential oil and some mines
Material element etc. can enhance immune function, anti-oxidant, antianxiety, anti-inflammatory, improvement gastrointestinal environment and protection liver.It is modern
Clinical medicine report, jujube can reduce serum GPT levels, and jujube can increase the content of total serum protein and albumin.
For acute, chronic hepatitis, the higher patient of serum transaminase vigor of liver cirrhosis patient has good effect.Milk thistle, it is bitter, it is cool.
With clearing heat and promoting diuresis；Soothing liver-gallbladder function." Xinhua's book on Chinese herbal medicine outline ": there is the function of removing toxic substances.Main component is flavanolignan's class
Mixture, mainly include silibinin (silybin), Isosilybin (isosilybin), silydianin (silydianin),
7 kinds of compounds such as Silychristin (silychristin).Silibinin as hepatic be widely used in treat hepatitis and
The metabolic diseases such as toxic liver injury.Its mechanism be anti-oxidant, anti peroxidation of lipid, anti-fibrosis, cell membrane stability effect and
Immunological regulation, and liver regeneration ability can be enhanced, referred to as " natural hepatoprotective agent ", and long term usage is harmless.Asiatic plantain, it is sweet, it trembles with fear.Return
Liver, kidney, lung, small intestinl channel.With reducing fever and causing diuresis, eliminating the phlegm, cool blood, function of detoxification.Aucubin contained by it can protect liver
It is dirty, carbon tetrachloride and α-poison fly Qin Su virulence are fought, the benzyl carbinol glucose glycoside compound obtained in the Asiatic plantain
(phenyle thanoid glycosides) has antioxidation." China's book on Chinese herbal medicine " carries: it is applied alone Asiatic plantain to prepare electuary, it can
For acute, chronic hepatitis.Three medicines share, synergistic, can prevent Mycotoxins in Feed, chemical antimicrobial DP finish crosses use and its
To security risk caused by livestock and poultry, effect is certain for his toxin, and the symptom that above-mentioned toxin damages livestock and poultry can be effectively relieved, and eliminates
To liver and kidney of livestock and poultry tissue damage, it is slow to be suitable for the growth of animals or poultry as caused by feed toxin poisoning etc..
The Chinese medicine compound prescription additive of animal and fowl fodder of the present invention, is added in animal and fowl fodder according to 2%, monthly feeds
10 days, continuous feeding 3 months can promote livestock birds health to grow, improve production performance, reduce mould poison remaining in feed
Element, chemical antimicrobial DP finish and other toxin are to security risk caused by livestock and poultry.Suitable for being caused by all feeds toxin etc.
Growth of animals or poultry it is slow.
It is had shown that through pharmacology test and animal experiment research, the traditional Chinese medicine extraction compound pharmaceutical is mould to chemical toxicant and feed
Livestock and poultry hepatic injury caused by verticillium toxin has preferable preventive and therapeutic action.Thin-layer chromatography and the high performance liquid chromatography inspection established
Survey method can detect the quality of Chinese medical extract compound preparation.
Specific embodiment
Come that the present invention is further explained by the following examples for hepatic injury caused by livestock and poultry a variety of causes Chinese medicine it is multiple
Square additive and preparation method thereof.Following embodiment is mainly used for further illustrating the present invention, rather than limits of the invention
Range.
Embodiment 1
A kind of Chinese medicine compound prescription additive for animal and fowl fodder, is made: red date powder of the raw material of following weight percentage
950g, milk thistle extract (silibinin content is 10%) 20g, Herba Plantaginis extract 30g, mixes well and loose powder is made,
It is added in feed according to 2%.
Pharmacodynamics test is carried out by following 2 tests, 1 Chinese herbal feed additive is to CCl4Cause the guarantor of laying hen hepatic injury
Shield effect；2 Chinese herbal feed additives cause the protective effect of laying hen injury of kidney to gentamicin sulphate.
1 Chinese medicine compound prescription additive of the invention is to CCl4Cause the protective effect of laying hen hepatic injury
By prerun, determine to young layer (500g or so) stomach-filling 50%CCl42mL, 72h can successfully build acute
Liver injury model.It the results are shown in Table 1 and table 2.
The situation of change of ALT, AST in 1 prevention group of table, model group and blank group chicken plasma
Note: * * and model group ratio, (P < 0.01)；* with model group ratio, (P < 0.05)；## and blank group ratio, (P < 0.01), #
With blank group ratio, (P < 0.05).Similarly hereinafter.
After prevention group first feeds feed containing Chinese medicine compound prescription 3 days, stomach-filling 50%CCl42mL attacks poison, and it is multiple containing Chinese medicine to continue feeding
Square feed takes a blood sample, measures ALT, AST in blood plasma, the results are shown in Table 1, there were significant differences with model group for prevention group, with blank on the 8th day
Group comparing difference is not significant, illustrates through stomach-filling CCl4Front and back Chinese medicine compound prescription has restored ALT in chicken serum, AST substantially just
Ordinary water is flat.Illustrate that Chinese medicine compound prescription plays the role of good preventing liver injury.
The situation of change of ALT, AST in 2 treatment group of table, model group and blank group chicken plasma
Treatment group is after modeling success, and feeding feed containing Chinese medicine compound prescription, blood sampling in the 6th day measures ALT in blood plasma, and AST contains
Amount, the results are shown in Table 2；There were significant differences with model group by ALT in treatment group's blood plasma, AST, illustrates that Chinese medicine compound prescription has treatment to hepatic injury
Effect.With blank group there were significant differences explanation with after Chinese medicine 3 days, serum alt, though AST level decreases, but without extensive
Again to normal level.
Clinical symptoms and dissect variation
It attacks sleeping ground interior for 24 hours after poison not rise, diet is intended to abolish or decline.It attacks the poison same day and attacks the 1st day discharge yellow green after poison
Loose stools, the 1st day each group can stand walking, but the individual chicken astasias of model group after contamination.Diet is intended to after contamination have for the 1st day
Restored, is returned to normal within the 4th day.During this period, vomiting is often accompanied by when diet.
Dissect is as it can be seen that the various liver kidneys of blank group are normal.Model group liver swelling, yellowish, close to liver tip
Surface have a canescence necrosis region, the slight enlargement for the treatment of group's liver, part is turned to be yellow, and only has size as needle cap in liver tip end surface
Canescence necrosis region.Prevention group liver size is normal, and liver color is slightly turned to be yellow.
Sections observation
Blank group hepatic tissue structural integrity；Nucleus is in hyacinthine, and cytoplasm pinkiness has no steatosis and inflammatory
Cellular infiltration.Model group liver cell loses normal cord structures, and liver rope is disorganized, fibroblast proliferation between cell rope,
Central vein deformation；Swelling of liver cell and be in blister steatosis, full of the round fat drips to differ in size in cytoplasm.Wherein prevent
Group damage is lighter, mild fatty denaturation.
2 Chinese medicine compound prescription additives of the invention cause the protective effect of laying hen injury of kidney to gentamicin sulphate
To young layer (500g or so) intramuscular injection gentamicin sulphate 2mL, continuous injection 7 days causes injury of kidney mould
Type divides three groups and is tested, and detects serum urea nitrogen (BUN) and serum creatinine (Cr), the results are shown in Table 3.Prevention group is before attacking poison
Gavage Chinese medicine compound prescription 3 days, there were significant differences with model group by BUN and Cr in off-test blood sampling measurement serum, illustrates Chinese medicine compound prescription
There is protective effect to injury of kidney.
BUN and Cr measurement result in 3 serum of table
Clinical symptoms and dissect variation
With the injection of gentamicin sulphate, the 3rd day drink appetite stimulator of model group is often accompanied by vomiting.It is dilute that yellow green is discharged
Just, individual chicken astasias.
Dissect is as it can be seen that Normal group chicken kidney is normal.Model group kidney swelling.
Embodiment 2
It is weighted according to the following proportion Chinese medicine and extract: red date powder 1900g, (silibinin content is milk thistle extract
10%) 40g, Herba Plantaginis extract 60g, mix well and loose powder are made.
Chinese medicine compound prescription additive of the invention is to the mould protective effect for losing feed and causing laying hen hepatic injury
Mouldy mould of nature loses feed, and being detected wherein aflatoxin B1 content is 3.2 μ g/Kg, Gibberella zeae alkene
Ketone content is 70.2 μ g/Kg, 340 μ g/Kg of deoxynivalenol.
It will be tested using random manner and be divided into positive controls and negative control group and the present invention with 150 young layers
The high, medium and low dosage group of Chinese medicine compound prescription additive, totally 5 groups, every group 30.Negative control group gives basis in experiment periods
Daily ration.Remaining 4 groups feed moldy feed within experimental period, and wherein positive controls are not processed, Chinese medicine compound prescription of the invention
Additive divides high dose group (4%), middle dose group (2%), low dose group (1%).Above 5 groups of equal free waters, experimental period be
42d.In test the 35th day, detection chicken serum glutamic-pyruvic transaminase (ALT), glutamic-oxalacetic transaminease (AST), alkaline phosphatase (ALP) became
Change the variation with proleulzin (IL-2), interferon-γ (IFN-γ) in serum.It the results are shown in Table 3.In test the 42nd day, dissect,
Tissue preparation paraffin section is taken, is observed.
Chicken plasma biochemical indicator and immune factor measurement result (U/L) when 3 35d of table
In 35 days test results, middle dosage feed addictive effect is best, and ALP, AST and ALT have a significant impact
(P ﹤ 0.05 or P ﹤ 0.01), and AST and ALT are close to negative control group, it is extremely significant (P ﹤ 0.01) with positive controls difference.Exempt from
In terms of the epidemic disease factor, each additive amount group is improved with positive controls, each dosage group all with extremely significant (the P ﹤ of positive controls difference
0.01), illustrate that the damage of mycotoxin still remains, and as time increases, damage is also more serious.Wherein middle dosage
Group IFN-γ and negative control group significant difference (P ﹤ 0.05) IL-2 are on close level negative control group.
Influence to chicken weight
It is shown in Table 4.As a result during finding out entire test, the weight levels of positive controls are compared with other groups compared to relatively low.It says
Mycotoxin in bright mildew feed has an impact to laying hen weight.And feed each group for adding Chinese medicine compound prescription additive of the invention
It is all improved compared with positive controls and close to normal level.
Each group laying hen changes of weight (g) during table 4 is tested
Clinical symptoms and dissect variation
After addition mildew feed, positive controls drink appetite stimulator, apathetic, passage of loose stools.Other each dosage group shapes
State is good.Dissect, the various livers of blank group and immune organ are normal.The slight swelling of positive controls liver, yellowish.
Pathology section examination
Liver, kidney pathological change are acquired and observed, paraffin section is prepared.Respectively carry out conventional H E dyeing, PAS dyeing and
The detection of TUNEL method, microscopic observation each group chicken liver and kidney structure variation, glycogen distribution and Apoptosis situation.As a result
It has been shown that, liver cell obvious tumefaction, lobuli hepatis boundary is fuzzy, and swelling, Histopathology structure observation occur for renal cells
Confirm modeling success.When 4% dosage, liver cell is clear in structure, no denaturation, necrosis, and glomerulus and renal tubule structure are typical；Liver is thin
Born of the same parents' cytoplasm is interior, renal tubular epithelial has more and intensive rhodo coloured particles, there is minute quantity apoptotic cell, hepatic and renal tissue structure, glycogen
Content and apoptosis degree are close with negative control group.1%, 2% dosage group has different degrees of improvement, liver, nephrocyte swelling
Degree reduces, and glycogen content increased, and apoptotic cell rate decreases.
Embodiment 3
Chinese medicine compound prescription additive of the invention is by milk thistle extract (silibinin content is 10%) 1.5kg, Asiatic plantain
Extract 2.5kg, red date powder 96kg, said medicine are uniformly mixed, and loose powder, total amount 100kg is made.Said medicine mixing is equal
It is even, loose powder is made.
It is applied in Yuncheng, Shanxi chicken farm in March, 2018, the 60 brown laying hens of age in days youth Hai Lan amount to 10,000, wherein
2000 are added in feed only according to 2%, monthly feed 10 days, and continuous feeding 3 months, laying hen health, cluster growth is well-balanced, opens
In postpartum, egg is well-balanced, and breaking soft egg number reduces, and average egg weight increases nearly 10 grams, and food consumption rate reduces, and the obvious color of eggshell is red, skin
Thick, good hand touch.
Embodiment 4
Chinese medicine compound prescription additive of the invention is mentioned by milk thistle extract (silibinin content is 10%) 1kg, Asiatic plantain
Take object 2kg, red date powder 97kg, total amount 100kg.Said medicine is uniformly mixed, and 10000 chick are added to feed according to 2%
In, it monthly feeds 10 days, continuous feeding 3 months, average weight increases, and food consumption rate reduces.
Embodiment 5
Chinese medicine compound prescription additive by milk thistle extract (silibinin content be 10%) 2kg, Herba Plantaginis extract 3kg,
Red date powder 95kg, said medicine are uniformly mixed, and loose powder, total amount 100kg is made.Said medicine is uniformly mixed, and loose powder is made.
It is tested on Shanglou Zhashui pig farm, after use, sow searches for food in lactation period, and after 5 days, constipation is improved, and feed intake increases
Add, lactation amount increases, and piglet is averagely weaned number of days 26.3 days；Average 18.3 jin of weanling weight.
It the above, preferred embodiments only of the invention, therefore variation in the case where not departing from present general inventive concept and repairs
Change, should belong within protection scope of the present invention.
Claims (3)
1. a kind of Chinese medicine compound prescription additive for animal and fowl fodder, which is characterized in that be made of the raw material of following weight percentage:
Red date powder 95~97%, milk thistle extract 1~2%, Herba Plantaginis extract 2~3%, the sum of mass percent of above-mentioned raw materials
It is 100%；
Silibinin content is 10% in the milk thistle extract.
2. a kind of Chinese medicine compound prescription additive for animal and fowl fodder according to claim 1, which is characterized in that by following heavy
The raw material of amount percentage is made: red date powder 96%, milk thistle extract 1.5%, Herba Plantaginis extract 2.5%, above-mentioned raw materials
The sum of mass percent is 100%.
3. a kind of application of the Chinese medicine compound prescription additive for animal and fowl fodder described in claim 1 in production animal and fowl fodder.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110237684A (en) * | 2019-06-05 | 2019-09-17 | 万沪(广州)科技有限公司 | A kind of disease-prevention health plant nanometer material and preparation method thereof |
| CN110651912A (en) * | 2019-11-04 | 2020-01-07 | 江苏隆达生物科技有限公司 | Laying hen premix for producing antioxidant eggs |
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