CN109180451A - 2,3-二甲氧基肉桂醛的制备方法 - Google Patents

2,3-二甲氧基肉桂醛的制备方法 Download PDF

Info

Publication number
CN109180451A
CN109180451A CN201810977304.1A CN201810977304A CN109180451A CN 109180451 A CN109180451 A CN 109180451A CN 201810977304 A CN201810977304 A CN 201810977304A CN 109180451 A CN109180451 A CN 109180451A
Authority
CN
China
Prior art keywords
dimethoxycinnamaldehyde
added
preparation
room temperature
milligrams
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201810977304.1A
Other languages
English (en)
Inventor
不公告发明人
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shanghai Hua Zi Biological Technology Co Ltd
Original Assignee
Shanghai Hua Zi Biological Technology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai Hua Zi Biological Technology Co Ltd filed Critical Shanghai Hua Zi Biological Technology Co Ltd
Priority to CN201810977304.1A priority Critical patent/CN109180451A/zh
Publication of CN109180451A publication Critical patent/CN109180451A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds

Abstract

本发明的名称是2，3‑二甲氧基肉桂醛的制备方法。所属的技术领域是医药技术。本发明所要解决的技术问题为涉及一种更为先进的2,3‑二甲氧基肉桂醛的制备方法。本发明所要解决的技术问题的技术方案的要点是该化合物的一种新的制备方法。

Description

2,3-二甲氧基肉桂醛的制备方法
技术领域
本发明涉及医药技术领域，具体而言，本发明涉及一种2,3-二甲氧基肉桂醛的制备方法。
背景技术
2,3-二甲氧基肉桂醛是一种重要的合成医药产品的中间体原料。
已有的2,3-二甲氧基肉桂醛的制备方法收率不高，合成工艺复杂，收率不稳定，需要发明一种新的制备方法，来克服已有技术的不足。
发明内容
本发明采用一种新技术，针对已有的2,3-二甲氧基肉桂醛的制备方法收率不高，合成工艺复杂，收率不稳定，所需原材料的采购成本高的缺点，经过长期的研发，发明了一种新的制备方法，来克服已有技术的不足，为以后的工业生产奠定了良好的技术基础。
本发明的技术方案是：
在反应器中加入1662毫克2,3-二甲氧基苯甲醛，加入乙腈20毫升，搅拌中，室温中加入3毫升的乙醛，然后室温搅拌20分钟，再加入1200毫克的氢氧化钾，然后持续在室温中搅拌反应2小时。反应完毕后，经后处理与纯化过程，得到化合物2，3-二甲氧基肉桂醛，收率为86.6％。
具体实施方式
实施例1：2,3-二甲氧基肉桂醛的制备：
在反应器中加入1662毫克2,3-二甲氧基苯甲醛，加入乙腈20毫升，搅拌中，室温中加入3毫升的乙醛，然后室温搅拌20分钟，再加入1200毫克的氢氧化钾，然后持续在室温中搅拌反应2小时。反应完毕后，经后处理与纯化过程，得到化合物2，3-二甲氧基肉桂醛，收率为86.6％。
实施例2：2,3-二甲氧基肉桂醛的制备：
在反应器中加入1662毫克2,3-二甲氧基苯甲醛，加入乙腈20毫升，搅拌中，室温中加入3毫升的乙醛，然后室温搅拌20分钟，再加入1200毫克的氢氧化钾，然后持续在室温中搅拌反应2小时。反应完毕后，经后处理与纯化过程，得到化合物2，3-二甲氧基肉桂醛，收率为85.8％。
本发明可用其他的不违背本发明的精神或主要特征的具体形式来概述。因此，无论从哪一点来看，本发明的上述实施方案都只能认为是对本发明的说明而不能限制本发明。

Claims (2)

1.2,3-二甲氧基肉桂醛的制备方法，其特征是：
在反应器中加入1662毫克2,3-二甲氧基苯甲醛，加入乙腈20毫升，搅拌中，室温中加入3毫升的乙醛，然后室温搅拌20分钟，再加入1200毫克的氢氧化钾，然后持续在室温中搅拌反应2小时。反应完毕后，经后处理与纯化过程，得到化合物2，3-二甲氧基肉桂醛，收率为86.6％。
2.根据权利要求1所述的方法，其特征是:
在反应液中需要加入化合物氢氧化钾。
CN201810977304.1A 2018-08-27 2018-08-27 2,3-二甲氧基肉桂醛的制备方法 Pending CN109180451A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810977304.1A CN109180451A (zh) 2018-08-27 2018-08-27 2,3-二甲氧基肉桂醛的制备方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201810977304.1A CN109180451A (zh) 2018-08-27 2018-08-27 2,3-二甲氧基肉桂醛的制备方法

Publications (1)

Publication Number Publication Date
CN109180451A true CN109180451A (zh) 2019-01-11

Family

ID=64919912

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201810977304.1A Pending CN109180451A (zh) 2018-08-27 2018-08-27 2,3-二甲氧基肉桂醛的制备方法

Country Status (1)

Country Link
CN (1) CN109180451A (zh)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002000022A1 (en) * 2000-06-26 2002-01-03 Forskarpatent I Syd Composition for inhibiting feeding of weevils
CN106831383A (zh) * 2016-12-28 2017-06-13 中国科学院成都生物研究所 二芳基庚烷类化合物

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002000022A1 (en) * 2000-06-26 2002-01-03 Forskarpatent I Syd Composition for inhibiting feeding of weevils
CN106831383A (zh) * 2016-12-28 2017-06-13 中国科学院成都生物研究所 二芳基庚烷类化合物

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
HUIJUN DONG等: "Transition Metal-Catalyzed Synthesis of Pyrroles from Dienyl Azides", 《ORGANIC LETTERS》 *
LI LIN等: "Antitumor Agents. 250.† Design and Synthesis of New Curcumin Analogues as Potential Anti-Prostate Cancer Agents", 《J. MED. CHEM.》 *
PRANAB KUMAR MAHATA等: "Formation of acetaldehyde enolate from vinyl acetate and its reaction with aromatic and heterocyclic aldehydes:an efficient synthesis of eanls and polyenals", 《SYNLETT》 *
RISHAN LANG NONGKHLAW等: "Synthesis of substituted hexa-3,5-dienoic acid methyl esters from conjugated dienones", 《J. CHEM. SOC., PERKIN TRANS.1》 *
SANDEEP VERMA等: "Interfacial Electron-Transfer Dynamics on TiO2 and ZrO2 Nanoparticle Surface Sensitized by New Catechol Derivatives of Os(II)-polypyridyl Complexes: Monitoring by Charge-Transfer Emission", 《J. PHYS. CHEM. C》 *

Similar Documents

Publication Publication Date Title
CN109096091A (zh) 肉桂酸的制备方法
CN103194501B (zh) 利用氨基转移酶合成手性环状烷基氨基酸的方法
CN102432614A (zh) 腔肠素的合成方法
CN108863773A (zh) 3-甲氧基肉桂酸的制备方法
CN109180451A (zh) 2,3-二甲氧基肉桂醛的制备方法
CN108794317A (zh) 2,3-二甲氧基苯甲醛的制备方法
CN108976109A (zh) 肉桂醛的制备方法
CN108863745A (zh) 3-羟基肉桂醛的制备方法
CN109020794A (zh) 3-甲氧基肉桂醛的制备方法
CN109020795A (zh) 4-甲氧基肉桂醛的制备方法
CN109020793A (zh) 4-羟基肉桂醛的制备方法
CN108794337A (zh) 一种3,4-二羟基-β-硝基苯乙烯的新制备方法
CN103951590B (zh) N,o-二甲基-n’-硝基异脲的制备方法
CN108863772A (zh) 4-甲氧基肉桂酸的制备方法
CN108484425A (zh) 一种天然左旋多巴的精制纯化方法
CN108623462A (zh) 一种4-羟基-β-硝基苯乙烯的新制备方法
CN108863804A (zh) 一种3,5-二甲氧基-β-硝基苯乙烯的新制备方法
CN108689856A (zh) 一种3-羟基-β-硝基苯乙烯的新制备方法
CN108929228A (zh) 一种3-甲氧基-β-硝基苯乙烯的新制备方法
CN108752214A (zh) 一种2-羟基-β-硝基苯乙烯的新制备方法
CN108929229A (zh) 一种4-氯-β-硝基苯乙烯的新制备方法
CN108863803A (zh) 一种4-甲氧基-β-硝基苯乙烯的新制备方法
CN108586259A (zh) 一种2-甲氧基-β-硝基苯乙烯的新制备方法
CN108658778A (zh) 一种3,4-二甲氧基-β-硝基苯乙烯的新制备方法
CN109053435A (zh) 2,3-二甲氧基苯甲酰氯的制备方法

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20190111