CN109172757A - A kind of Chang Tong Bian Granules - Google Patents
A kind of Chang Tong Bian Granules Download PDFInfo
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Abstract
The invention discloses a kind of Chang Tong Bian Granules, it is made of raw materials such as fructus cannabis, the sophora bud, Siraitia grosvenorii, fructus lycii, dried orange peel, FLOS CHRYSANTHEMI ALBA from Haizhou of China, lophatherum gracile, hawthorn, resistant dextrin, maltitol, inulin, jasmine tea extracts.Chinese medicine nourishing-to-relaxing selected by the present invention, it is secret from originally controlling, anthraquinones are not contained, effect more mitigates, will not generate stimulation to intestinal mucosa, not only prevent the generation of Melanosis coli, but also will not generate dependence, will not recur after drug withdrawal.Therefore the present invention is a kind of curative for effect, safe and reliable relax bowel and defecation Chinese medicine.
Description
Technical field
The invention belongs to the field of Chinese medicines, are related to a kind of Chang Tong Bian Granules.
Background technique
With the influence of the factors such as the accelerating rhythm of life, the change of eating habit and society, psychology, the hair of China's constipation
Sick rate is higher and higher, and is in rise year by year trend.Constipation was occurred together in each age, although the life of people will not be threatened directly,
But strong influence is brought to people's lives, work.There are many harm of constipation, can not only aggravate protopathy, while can also
Cardiovascular and cerebrovascular disease is induced, colon cancer, senile dementia, failure of memory etc. are caused.
Raw material selected in defaecation Chinese medicine or health food ingredients type is substantially with rheum officinale, aloe, cassia angustifolia in the market
Leaf, cassia seed etc. are in the majority.Such strength cathartic containing anthraquinones, to the irritating effect of intestinal mucosa, the time has grown meeting
It causes intestinal mucosa pathology to sexually revise, is clinically Melanosis coli.Melanosis coli is presently believed to be a kind of precancerous lesion,
It can cause colon cancer.Chronic habitual constipation crowd is used for a long time containing rheum officinale, aloe or the drug of folium sennae, can form dependence
Property, and as dosage can be increasing, it is invalid to eventually lead to.
Summary of the invention
The technical problem to be solved in the present invention is to provide one kind to contain anthraquinone without rheum officinale, aloe, folium sennae, cassia seed etc.
Substance and rapid, the eutherapeutic Chang Tong Bian Granules that work.
In order to solve the above technical problems, the present invention adopts the following technical scheme:
A kind of Chang Tong Bian Granules are made of the raw material of following portions by weight: 1-18 parts of fructus cannabis, 1-15 parts of the sophora bud,
1-8 parts of Siraitia grosvenorii, 1-12 parts of fructus lycii, 1-15 parts of dried orange peel, 1-7 parts of FLOS CHRYSANTHEMI ALBA from Haizhou of China, 1-17 parts of lophatherum gracile, 1-7 parts of hawthorn, resistant dextrin
1-9 parts, 1-12 parts of maltitol, 1-12 parts of inulin, 1-12 parts of jasmine tea extract.
To further increase relax bowel and defecation effect, currently preferred raw material weight number are as follows: 15 parts of fructus cannabis, the sophora bud 12
Part, 5 parts of Siraitia grosvenorii, 8 parts of fructus lycii, 10 parts of dried orange peel, 5 parts of FLOS CHRYSANTHEMI ALBA from Haizhou of China, 9 parts of lophatherum gracile, 3 parts of hawthorn, 3 parts of resistant dextrin, maltose
8 parts of alcohol, 6 parts of inulin, 2 parts of jasmine tea extract.
Above-mentioned Chang Tong Bian Granules are prepared using following methods:
1) it gets fire edestan, the sophora bud, Siraitia grosvenorii, fructus lycii, dried orange peel, FLOS CHRYSANTHEMI ALBA from Haizhou of China, lophatherum gracile, hawthorn, water is added to carry out decoction extraction,
Extracting solution is collected after filtering；
2) complex enzyme is added into extracting solution, 1-5h is digested under conditions of 35-60 DEG C, then heating, which is boiled, makes enzyme-deactivating
The clear cream that relative density is 1.05-1.15 is concentrated under reduced pressure into afterwards；
3) ethyl alcohol is added into clear cream, so that ethyl alcohol weight content is reached 40-70%, is stood overnight after stirring；
4) thick paste for being 1.25-1.35 at relative density is concentrated under reduced pressure in the supernatant after taking alcohol precipitation；Take resistant dextrin, wheat
Bud sugar alcohol, inulin, jasmine tea extract, are placed in spray granulator, spraying granulation are carried out with thick paste, up to granule after drying.
The present invention digests extracting solution by adding complex enzyme, and the macromolecular substances in Chinese medicine are resolved into small point
Son, realizes the conversion of active constituent, has not only effectively facilitated being absorbed and utilized for drug, improves curative effect of medication, and makes
Solution rate faster, is more clarified when granula is taken after mixing it with water, and mouthfeel is more preferable, to improve patient compliance.Wherein, the kind of complex enzyme
There are crucial effect in class, ratio, the temperature of enzymatic hydrolysis, time to the content of active constituent, the curative effect of drug and property, and the present invention is preferred
Complex enzyme be made of cellulase, pectase, amylase and neutral proteinase, dosage is respectively the 0.8- of extracting solution weight
1.5%, 0.2-0.6%, 0.2-0.6%, 0.1-0.5%.It is optimal, the cellulase, pectase, amylase and neutral egg
The dosage of white enzyme is respectively 1.2%, 0.5%, 0.5%, the 0.3% of extracting solution weight.Optimal enzymatic hydrolysis parameter is: 45 DEG C of item
3h is digested under part.
In addition, decocting the active component content of the concentration against drug of the time extracted, number, amount of water and alcohol precipitation, treating
Effect and dissolubility etc. also have a major impact, wherein the purpose of alcohol precipitation be in order to remove the protein in clear cream, tannin, polysaccharide and
The impurity such as the enzyme being inactivated.The optimal decoction extraction of the present invention is plus 6 times of weight waters decoct and extracted 2 times, every time 2 hours.
When alcohol precipitation, optimal concentration of alcohol is 65%.
The invention has the following advantages:
Chinese medicine nourishing-to-relaxing selected by the present invention, it is secret from originally controlling, anthraquinones are not contained, effect more mitigates,
Stimulation will not be generated to intestinal mucosa, not only prevent the generation of Melanosis coli, but also dependence will not be generated, after drug withdrawal not
It can recur.Therefore the present invention is a kind of curative for effect, safe and reliable relax bowel and defecation Chinese medicine.
Prescription of the present invention is rigorous, preparation method is scientific.Fructus cannabis is sweet in side puts down glossy, can control void and reality constipation；Siraitia grosvenorii
Cool blood in sweet flavor, clearing lung-heat ease constipation, this two taste not only lead clearly real heat, but also profit is supported and taken into account, and is monarch drug in a prescription.Lophatherum gracile is sweet light, clear benefit cold in nature, is apt to
Rush down lower heat-clearing；FLOS CHRYSANTHEMI ALBA from Haizhou of China purging with bitter and cold drugs is apt to purging intense heat cool liver；The sophora bud lets out clearly promoting, clearing heat and cooling blood, and three tastes are total to principal drug assistance and rush down stomach clearly
It is damp and hot stagnant, therefore be ministerial drug；Fructus lycii is sweet flat, nourishing Yin and promoting production of body fluid, increases liquid and moisturizes, and is apt to nourishing the liver and kidney yin jin with ease constipation road, is also ministerial drug.
Dried orange peel fragrance invigorating the spleen middle benefit gas, benefaction stomach and intestine stagnant gas promote body fluid to dredge cloth；Hawthorn appetite-stimulating and indigestion-relieving, the stagnant disperse accumulation of change, blood-activating and qi-promoting, two
Medicine shares, and is altogether adjutant to prevent the bitter cold too impairment of the spleen to increase the power of monarch-minister drug relax bowel and defecation, and middle benefit gas.Complete square compatibility 5,
Main clear laxative and profit are supported, and play promoting of purging heat, the function of relax bowel and defecation altogether, therefore are apt to control heat knot Tianjin hinder constipation, long-term bed constipation, a period of time
Property abdominal distention constipation, the elderly habitual constipation are all suitable.
Meanwhile containing resistant dextrin and inulin dietary fiber in formula, it is not absorbed in small enteral, large intestine can be directly entered,
Growth, the breeding that can promote intestine beneficial bacteria colony, are a kind of Bifidobacterium proliferation factors, adjust intestinal flora, have and promote stomach
Bowel movement improves the function of gastrointestinal tract dyskinesis.Dietary fiber water swelling can increase faecal volume, promote intestines peristalsis,
There is good preventive effect for constipation.The requirement of root Ju color, the present invention add jasmine tea extract and maltitol, are made
Granule pleasant aroma, fresh and clean, soup look is limpid beautiful, and mouthfeel is sweet fresh refreshing.
Specific embodiment
The present invention is described in detail below in conjunction with specific embodiment.
Influence of the different prescriptions of traditional Chinese medicine of embodiment 1 to mouse bowel movement function
The prescriptions of traditional Chinese medicine of embodiment 1-10 see the table below 1.
1 prescriptions of traditional Chinese medicine table (g) of table
The prescriptions of traditional Chinese medicine of Example 1-10, it is spare to be ground into fine powder, as given the test agent.
Select bull ICR mouse 144, weight 18-22g, be randomly divided into 12 groups (embodiment 1-10 group, blank group,
Model group), every group 12.Embodiment 1-10 group presses 6.5g/kg dosage gastric infusion, blank control group and model control group stomach-filling
To distilled water, continuous gavage 15d.
After 15d, each group mouse is deprived of food but not water for 24 hours.Blank group gives distilled water, and model group and 10 test group stomach-fillings are given
Give compound diphenoxylate (10mg/kgBW).After compound diphenoxylate 0.5h, blank control group and model control group mouse are used
Prepared Chinese ink stomach-filling, test group give the prepared Chinese ink containing given the test agent, the equal single cage raising of animal, normal water feed.Since filling prepared Chinese ink,
It records every animal first grain row's melena time, arrange melena grain number and quality in 6h, while observing fecal character.It the results are shown in Table 2.
Influence of the Chinese medicine of the present invention of table 2 to mouse defecation
| Group | Defecation time (min) for the first time | Fecal grains (grain) | Stool weight (g) |
| Blank group | 143 | 18.7 | 0.77 |
| Model group | 267 | 8.6 | 0.38 |
| Embodiment 1 | 221 | 11.5 | 0.45 |
| Embodiment 2 | 194 | 13.4 | 0.56 |
| Embodiment 3 | 205 | 12.3 | 0.51 |
| Embodiment 4 | 188 | 14.6 | 0.59 |
| Embodiment 5 | 209 | 11.7 | 0.57 |
| Embodiment 6 | 195 | 13.1 | 0.52 |
| Embodiment 7 | 176 | 14.2 | 0.62 |
| Embodiment 8 | 215 | 11.3 | 0.49 |
| Embodiment 9 | 206 | 12.5 | 0.58 |
| Embodiment 10 | 190 | 13.3 | 0.60 |
As can be seen from the above results, compared to the blank group, the defecation time for the first time of model group extends, fecal grains and again
Amount is reduced, and has significant difference (P < 0.05), shows the success of mice with constipation model foundation.Compared with model group, implement
Example 1-10 can shorten defecation time for the first time, increase fecal grains and weight, illustrate that Chinese medicine preparation of the invention is logical with ease constipation
Just effect, wherein embodiment 7 all has extremely significant difference (P < 0.01).
The experimental results showed that Chinese medicine of the present invention can promote Constipation Model mouse small intestine wriggling, softening stool shortens it for the first time
Defecation time increases fecal grains and stool quality, therefore has the function of relax bowel and defecation.The wherein action speed of embodiment 7
Most fast, defecation is best in quality.
Embodiment 11
Fructus cannabis 15Kg, sophora bud 12Kg, Siraitia grosvenorii 5Kg, fructus lycii 8Kg, dried orange peel 10Kg, FLOS CHRYSANTHEMI ALBA from Haizhou of China 5Kg, lophatherum gracile 9Kg, mountain
Short, bristly hair or beard 3Kg, resistant dextrin 3Kg, maltitol 8Kg, inulin 6Kg, jasmine tea extract 2Kg.
1) it gets fire edestan, the sophora bud, Siraitia grosvenorii, fructus lycii, dried orange peel, FLOS CHRYSANTHEMI ALBA from Haizhou of China, lophatherum gracile, hawthorn, adds 6 times of weight waters to carry out pan-fried
Extraction 2 times is boiled, 2 hours every time, collects extracting solution (total 850Kg) after filtering；
2) it is added into extracting solution by 10.2Kg cellulase, 4.25Kg pectase, 4.25Kg amylase and 2.55Kg
Property protease composition complex enzyme, 3h is digested under conditions of 45 DEG C, then heating boils and makes within 15 minutes enzyme-deactivating, by enzymolysis liquid
The clear cream that relative density is 1.1 is concentrated under reduced pressure into；
3) dehydrated alcohol is added into clear cream, so that ethyl alcohol weight content is reached 65%, is stood overnight after stirring；
4) thick paste for being 1.32 at relative density is concentrated under reduced pressure in the supernatant after taking alcohol precipitation；Take resistant dextrin, maltose
Alcohol, inulin, jasmine tea extract, are placed in spray granulator, spraying granulation are carried out with thick paste, up to granule after drying.
It is detected through efficient liquid phase, dried orange peel glycosides content is 0.16mg/g in granule.
Embodiment 12
Raw material prescription is identical as embodiment 11.
1) it gets fire edestan, the sophora bud, Siraitia grosvenorii, fructus lycii, dried orange peel, FLOS CHRYSANTHEMI ALBA from Haizhou of China, lophatherum gracile, hawthorn, 12 times of weight waters is added to carry out
It decocts and extracts 1 time, the time 3 hours, collect extracting solution (total 900Kg) after filtering；
2) it is added into extracting solution by 13.5Kg cellulase, 2.7Kg pectase, 2.7Kg amylase and 4.5Kg neutrality egg
The complex enzyme of white enzyme composition, digests 1h under conditions of 60 DEG C, and then heating, which is boiled, makes enzyme-deactivating, by enzymolysis liquid be concentrated under reduced pressure at
The clear cream that relative density is 1.05；
3) dehydrated alcohol is added into clear cream, so that ethyl alcohol weight content is reached 40%, is stood overnight after stirring；
4) thick paste for being 1.25 at relative density is concentrated under reduced pressure in the supernatant after taking alcohol precipitation；Take resistant dextrin, maltose
Alcohol, inulin, jasmine tea extract, are placed in spray granulator, spraying granulation are carried out with thick paste, up to granule after drying.
It is detected through efficient liquid phase, dried orange peel glycosides content is 0.13mg/g in granule.
Embodiment 13
Raw material prescription is identical as embodiment 11.
1) it gets fire edestan, the sophora bud, Siraitia grosvenorii, fructus lycii, dried orange peel, FLOS CHRYSANTHEMI ALBA from Haizhou of China, lophatherum gracile, hawthorn, adds 4 times of weight waters to carry out pan-fried
Extraction 3 times is boiled, 1 hour every time, collects extracting solution (total 800Kg) after filtering；
2) it is added into extracting solution by 8Kg cellulase, 4.8Kg pectase, 2.4Kg amylase and 1.6Kg neutral protein
The complex enzyme of enzyme composition, digests 5h under conditions of 35 DEG C, and then heating, which is boiled, makes enzyme-deactivating, and enzymolysis liquid is concentrated under reduced pressure into phase
The clear cream for being 1.15 to density；
3) ethyl alcohol is added into clear cream, so that ethyl alcohol weight content is reached 70%, is stood overnight after stirring；
4) thick paste for being 1.35 at relative density is concentrated under reduced pressure in the supernatant after taking alcohol precipitation；Take resistant dextrin, maltose
Alcohol, inulin, jasmine tea extract, are placed in spray granulator, spraying granulation are carried out with thick paste, up to granule after drying.
It is detected through efficient liquid phase, dried orange peel glycosides content is 0.11mg/g in granule.
Embodiment 14
Bull ICR mouse 48, weight 18-22g are selected, 4 groups of (embodiment 11-13 group and comparative examples are randomly divided into
Group), every group 12.Each embodiment and comparative example is by 6.5g/kg (being converted to raw medicinal herbs) dosage gastric infusion, continuous gavage
15d.After 15d, each group mouse is deprived of food but not water for 24 hours.Compound diphenoxylate (10mg/kgBW) is given in 3 test group stomach-fillings,
After 0.5h, test group gives the prepared Chinese ink containing given the test agent, record every animal first grain row's melena time, melena grain number is arranged in 6h and
Quality, while observing fecal character.Wherein comparative example is to prepare Chinese medicine according to conventional water boiling and extraction technique, will not
Extracting solution carries out enzymolysis processing.Test result is shown in Table 3.
Influence of 3 Chinese medicinal preparation method of table to mouse defecation
| Group | Defecation time (min) for the first time | Fecal grains (grain) | Stool weight (g) |
| Embodiment 11 | 158 | 16.8 | 0.71 |
| Embodiment 12 | 167 | 15.7 | 0.67 |
| Embodiment 13 | 170 | 15.1 | 0.65 |
| Comparative example | 173 | 14.6 | 0.64 |
As can be seen from the above results, it using preparation process of the invention, can further shorten defecation time, increase excrement
Grain number and weight, to improve Chinese medicine relax bowel and defecation effect.And it is unobvious to use particle curative effect made from common process to increase.
Embodiment 15
Selecting health, sub-health population is subject, observes effectiveness of the invention and safety, now ties related research
Fruit is reported as follows:
1, method: a pouch (2g) every time, it is one day two bags (4g), continuous 7 days edible.
2, observation item: (1) defecation frequency: examination trencherman takes 6 days and test-meal 7 days daily defecation feelings before test-meal sample
Condition.
(2) defecation condition: it is divided into IV grade of I- according to difficult defecation degree, integrated value before and after statistics test-meal.
I grades (0 point): defecation is normal；
II grades (1 point): only bearing down, sense of discomfort；
III grade (2 points): bearing down, sense of discomfort are obvious；Or have just frequency but difficult defecation and measure less, it is less abdominal pain or anus occur
Door burn feeling, influences defecation.
IV grade (3 points): abdominal pain often occur or anus burns and feels.
(3) fecal character: being III grade of I- according to Bristol (Bristol) fecal character classification.
I grades (0 point): smooth and soft as sausage or snake；As sausage, but there is slight crack on its surface；Soft agglomerate has bright
Aobvious edge (being easily drained).
II grades (1 point): sausage shape, but have agglomerate；Loose bulk, edge roughness, as slimy excrement.
III level (2 points): the hard group of separation, as fruit stone (being not easy to be discharged).
3, result judgement
Test-meal group itself compares before and after test-meal, and defecation frequency obviously increases；Defecation condition and fecal character, in binomial index
One index integral decline, can determine that the tested food has bowel relaxing functions effect.
4, investigation result
Investigation has constipation symptom crowd 31 altogether, and the age 32-57 years old, 31 times of defecation increased, and 26 defecation states change
Kind, 23 fecal characters improve, and efficiently individual quantity 26, total effective rate 83%.Had no during patient medication obvious adverse reaction and
Side effect checks no relapse after being discontinued 2 weeks.
Claims (8)
1. a kind of Chang Tong Bian Granules, it is characterised in that be made of the raw material of following portions by weight: 1-18 parts of fructus cannabis, the sophora bud
1-15 parts, 1-8 parts of Siraitia grosvenorii, 1-12 parts of fructus lycii, 1-15 parts of dried orange peel, 1-7 parts of FLOS CHRYSANTHEMI ALBA from Haizhou of China, 1-17 parts of lophatherum gracile, 1-7 parts of hawthorn,
1-9 parts of resistant dextrin, 1-12 parts of maltitol, 1-12 parts of inulin, 1-12 parts of jasmine tea extract.
2. Chang Tong Bian Granules according to claim 1, it is characterised in that be made of the raw material of following portions by weight: fire
15 parts of edestan, 12 parts of the sophora bud, 5 parts of Siraitia grosvenorii, 8 parts of fructus lycii, 10 parts of dried orange peel, 5 parts of FLOS CHRYSANTHEMI ALBA from Haizhou of China, 9 parts of lophatherum gracile, 3 parts of hawthorn, resistance
3 parts of dextrin, 8 parts of maltitol, 6 parts of inulin, 2 parts of jasmine tea extract.
3. Chang Tong Bian Granules according to claim 1 or 2, it is characterised in that preparation method the following steps are included:
1) it gets fire edestan, the sophora bud, Siraitia grosvenorii, fructus lycii, dried orange peel, FLOS CHRYSANTHEMI ALBA from Haizhou of China, lophatherum gracile, hawthorn, water is added to carry out decoction extraction, filter
After collect extracting solution；
2) complex enzyme is added into extracting solution, 1-5h is digested under conditions of 35-60 DEG C, then heating boil make enzyme-deactivating after subtract
Pressure is condensed into the clear cream that relative density is 1.05-1.15；
3) ethyl alcohol is added into clear cream, so that ethyl alcohol weight content is reached 40-70%, is stood overnight after stirring；
4) thick paste for being 1.25-1.35 at relative density is concentrated under reduced pressure in the supernatant after taking alcohol precipitation；Take resistant dextrin, maltose
Alcohol, inulin, jasmine tea extract, are placed in spray granulator, spraying granulation are carried out with thick paste, up to granule after drying.
4. Chang Tong Bian Granules according to claim 3, it is characterised in that: the complex enzyme is by cellulase, pectin
Enzyme, amylase and neutral proteinase composition, dosage is respectively 0.8-1.5%, 0.2-0.6%, 0.2- of extracting solution weight
0.6%, 0.1-0.5%.
5. Chang Tong Bian Granules according to claim 4, it is characterised in that: the cellulase, pectase, amylase
Dosage with neutral proteinase is respectively 1.2%, 0.5%, 0.5%, the 0.3% of extracting solution weight.
6. Chang Tong Bian Granules according to claim 3, it is characterised in that: the enzymatic hydrolysis is enzyme under conditions of 45 DEG C
Solve 3h.
7. Chang Tong Bian Granules according to claim 3, it is characterised in that: the decoction extraction is to add 6 times of weight waters
It extracts 2 times, every time 2 hours.
8. Chang Tong Bian Granules according to claim 3, it is characterised in that: in step 3), the weight of the ethyl alcohol contains
Amount is 65%.
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| CN111000002A (en) * | 2019-12-27 | 2020-04-14 | 广西国茗金花茶科技有限公司 | Camellia nitidissima functional tea capable of relaxing bowels and preparation method of camellia nitidissima functional tea |
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| CN111000002A (en) * | 2019-12-27 | 2020-04-14 | 广西国茗金花茶科技有限公司 | Camellia nitidissima functional tea capable of relaxing bowels and preparation method of camellia nitidissima functional tea |
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